[{"oa_version":"Published Version","month":"06","year":"2026","article_processing_charge":"No","degree_awarded":"PhD","ddc":["576"],"author":[{"last_name":"Khudiakova","first_name":"Kseniia","orcid":"0000-0002-6246-1465","full_name":"Khudiakova, Kseniia","id":"4E6DC800-AE37-11E9-AC72-31CAE5697425"}],"publication_status":"published","OA_place":"publisher","ec_funded":1,"publication_identifier":{"issn":["2663-337X"]},"supervisor":[{"last_name":"Barton","orcid":"0000-0002-8548-5240","full_name":"Barton, Nicholas H","first_name":"Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Jan","orcid":"0000-0002-0845-1338","full_name":"Maas, Jan","id":"4C5696CE-F248-11E8-B48F-1D18A9856A87","last_name":"Maas"}],"acknowledgement":"At different stages of my PhD, my work was supported by several grants: the\r\nDOC fellowship of the Austrian Academy of Sciences (26293, awarded to me),\r\nthe FWF-SFB grant (PT1032F06504 n. F65, awarded to Jan Maas), and the ERC\r\ngrant (PR1032ERC01 n. 716117, awarded to Jan Maas). I also appreciate the help\r\nfrom the Scientific Computing unit for their advice on the cluster usage.","date_created":"2026-05-27T06:26:08Z","department":[{"_id":"GradSch"},{"_id":"NiBa"},{"_id":"JaMa"}],"acknowledged_ssus":[{"_id":"ScienComp"}],"has_accepted_license":"1","alternative_title":["ISTA Thesis"],"related_material":{"record":[{"id":"11447","relation":"part_of_dissertation","status":"public"},{"id":"12513","status":"deleted","relation":"part_of_dissertation"},{"id":"21967","relation":"part_of_dissertation","status":"public"},{"status":"public","relation":"part_of_dissertation","id":"21968"}]},"citation":{"ista":"Khudiakova K. 2026. How epistasis and purifying selection shape genetic diversity. Institute of Science and Technology Austria.","ama":"Khudiakova K. How epistasis and purifying selection shape genetic diversity. 2026. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-21918\">10.15479/AT-ISTA-21918</a>","mla":"Khudiakova, Kseniia. <i>How Epistasis and Purifying Selection Shape Genetic Diversity</i>. Institute of Science and Technology Austria, 2026, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-21918\">10.15479/AT-ISTA-21918</a>.","ieee":"K. Khudiakova, “How epistasis and purifying selection shape genetic diversity,” Institute of Science and Technology Austria, 2026.","apa":"Khudiakova, K. (2026). <i>How epistasis and purifying selection shape genetic diversity</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-21918\">https://doi.org/10.15479/AT-ISTA-21918</a>","short":"K. Khudiakova, How Epistasis and Purifying Selection Shape Genetic Diversity, Institute of Science and Technology Austria, 2026.","chicago":"Khudiakova, Kseniia. “How Epistasis and Purifying Selection Shape Genetic Diversity.” Institute of Science and Technology Austria, 2026. <a href=\"https://doi.org/10.15479/AT-ISTA-21918\">https://doi.org/10.15479/AT-ISTA-21918</a>."},"corr_author":"1","tmp":{"name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","image":"/images/cc_by_nc_nd.png"},"day":"07","date_published":"2026-06-07T00:00:00Z","language":[{"iso":"eng"}],"file":[{"checksum":"0cff64ae74f0f9f2d7011700c82f700a","date_updated":"2026-06-09T08:40:48Z","file_size":20549813,"creator":"kkhudiak","relation":"source_file","date_created":"2026-06-09T08:34:38Z","file_id":"21965","access_level":"closed","content_type":"application/x-zip-compressed","file_name":"thesis.zip"},{"file_size":9387029,"checksum":"547ae42de37cc86894af283f1664dbc8","date_updated":"2026-06-11T12:14:53Z","relation":"main_file","date_created":"2026-06-09T12:28:51Z","creator":"kkhudiak","access_level":"closed","file_id":"21969","embargo_to":"open_access","content_type":"application/pdf","file_name":"2026_Khudiakova_Ksenia_Thesis.pdf","embargo":"2027-06-10"}],"fulldoi":"https://doi.org/10.15479/AT-ISTA-21918","status":"public","_id":"21918","project":[{"name":"Optimal Transport and Stochastic Dynamics","call_identifier":"H2020","_id":"256E75B8-B435-11E9-9278-68D0E5697425","grant_number":"716117"},{"_id":"34d33d68-11ca-11ed-8bc3-ec13763c0ca8","name":"The impact of deleterious mutations on small populations","grant_number":"26293"},{"_id":"fc31cba2-9c52-11eb-aca3-ff467d239cd2","name":"Taming Complexity in Partial Differential Systems","grant_number":"F6504"}],"type":"dissertation","doi":"10.15479/AT-ISTA-21918","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","publisher":"Institute of Science and Technology Austria","file_date_updated":"2026-06-11T12:14:53Z","title":"How epistasis and purifying selection shape genetic diversity","license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","page":"89","date_updated":"2026-06-12T12:43:35Z"},{"date_updated":"2026-06-12T12:43:34Z","license":"https://creativecommons.org/licenses/by-nc/4.0/","title":"Sign epistasis extends the effects of balancing selection on genetic diversity","abstract":[{"text":"Balancing selection, a form of selection that maintains genetic diversity, is difficult to detect, and the importance of balancing selection for the maintenance of genetic variation may be larger than often assumed. We model the possibility that the diversity-promoting effects of balancing selection extend to other loci that show sign epistasis with a locus under balancing selection. Rather than focusing on overdominance, as was done in previous efforts, we explore the effects of negative frequency dependence and show that this has important effects on the conditions under which the diversity-promoting effect of epistasis can occur in diploids. Our results show that not only recombination rate but also the dominance of sign epistasis are key parameters that determine the maintenance of polymorphism beyond the locus under direct balancing selection. We suggest that the effect we explore may play a significant role, especially when balancing selection acts on major effect loci.","lang":"eng"}],"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","doi":"10.1101/2025.04.09.647826","_id":"21968","status":"public","project":[{"grant_number":"26293","name":"The impact of deleterious mutations on small populations","_id":"34d33d68-11ca-11ed-8bc3-ec13763c0ca8"}],"type":"preprint","language":[{"iso":"eng"}],"fulldoi":"https://doi.org/10.1101/2025.04.09.647826","day":"23","date_published":"2026-04-23T00:00:00Z","tmp":{"name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","image":"/images/cc_by_nc.png","short":"CC BY-NC (4.0)"},"citation":{"ista":"Khudiakova K, Barton NH, Arnqvist G. Sign epistasis extends the effects of balancing selection on genetic diversity. bioRxiv, <a href=\"https://doi.org/10.1101/2025.04.09.647826\">10.1101/2025.04.09.647826</a>.","mla":"Khudiakova, Kseniia, et al. “Sign Epistasis Extends the Effects of Balancing Selection on Genetic Diversity.” <i>BioRxiv</i>, doi:<a href=\"https://doi.org/10.1101/2025.04.09.647826\">10.1101/2025.04.09.647826</a>.","ama":"Khudiakova K, Barton NH, Arnqvist G. Sign epistasis extends the effects of balancing selection on genetic diversity. <i>bioRxiv</i>. doi:<a href=\"https://doi.org/10.1101/2025.04.09.647826\">10.1101/2025.04.09.647826</a>","short":"K. Khudiakova, N.H. Barton, G. Arnqvist, BioRxiv (n.d.).","ieee":"K. Khudiakova, N. H. Barton, and G. Arnqvist, “Sign epistasis extends the effects of balancing selection on genetic diversity,” <i>bioRxiv</i>. .","apa":"Khudiakova, K., Barton, N. H., &#38; Arnqvist, G. (n.d.). Sign epistasis extends the effects of balancing selection on genetic diversity. <i>bioRxiv</i>. <a href=\"https://doi.org/10.1101/2025.04.09.647826\">https://doi.org/10.1101/2025.04.09.647826</a>","chicago":"Khudiakova, Kseniia, Nicholas H Barton, and Goran Arnqvist. “Sign Epistasis Extends the Effects of Balancing Selection on Genetic Diversity.” <i>BioRxiv</i>, n.d. <a href=\"https://doi.org/10.1101/2025.04.09.647826\">https://doi.org/10.1101/2025.04.09.647826</a>."},"corr_author":"1","related_material":{"record":[{"status":"public","relation":"dissertation_contains","id":"21918"}]},"date_created":"2026-06-09T12:26:11Z","department":[{"_id":"NiBa"},{"_id":"JaMa"}],"publication":"bioRxiv","acknowledgement":"This work was funded by grants from the Swedish Research Council (2023-03730 to G.A.) and the DOC fellowship from the Austrian Academy of Science (26293 to K.K.).","OA_place":"repository","OA_type":"green","author":[{"last_name":"Khudiakova","first_name":"Kseniia","orcid":"0000-0002-6246-1465","full_name":"Khudiakova, Kseniia","id":"4E6DC800-AE37-11E9-AC72-31CAE5697425"},{"last_name":"Barton","first_name":"Nicholas H","full_name":"Barton, Nicholas H","orcid":"0000-0002-8548-5240","id":"4880FE40-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Arnqvist","full_name":"Arnqvist, Goran","first_name":"Goran"}],"publication_status":"draft","year":"2026","oa":1,"article_processing_charge":"No","month":"04","main_file_link":[{"url":"https://doi.org/10.1101/2025.04.09.647826","open_access":"1"}],"oa_version":"Preprint"},{"article_type":"original","publication_status":"published","author":[{"last_name":"Olusanya","id":"41AD96DC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-1971-8314","full_name":"Olusanya, Oluwafunmilola O","first_name":"Oluwafunmilola O"},{"last_name":"Khudiakova","first_name":"Kseniia","full_name":"Khudiakova, Kseniia","orcid":"0000-0002-6246-1465","id":"4E6DC800-AE37-11E9-AC72-31CAE5697425"},{"last_name":"Sachdeva","id":"42377A0A-F248-11E8-B48F-1D18A9856A87","first_name":"Himani","full_name":"Sachdeva, Himani"}],"month":"06","issue":"6","intvolume":"       205","main_file_link":[{"url":"https://doi.org/10.1101/2023.12.02.569702","open_access":"1"}],"oa_version":"Preprint","article_processing_charge":"No","year":"2025","oa":1,"department":[{"_id":"JaMa"},{"_id":"NiBa"}],"scopus_import":"1","date_created":"2026-02-18T10:47:18Z","publication":"The American Naturalist","corr_author":"1","citation":{"ista":"Olusanya OO, Khudiakova K, Sachdeva H. 2025. Genetic load, eco-evolutionary feedback, and extinction in metapopulations. The American Naturalist. 205(6), 617–636.","mla":"Olusanya, Oluwafunmilola O., et al. “Genetic Load, Eco-Evolutionary Feedback, and Extinction in Metapopulations.” <i>The American Naturalist</i>, vol. 205, no. 6, University of Chicago Press, 2025, pp. 617–36, doi:<a href=\"https://doi.org/10.1086/735562\">10.1086/735562</a>.","ama":"Olusanya OO, Khudiakova K, Sachdeva H. Genetic load, eco-evolutionary feedback, and extinction in metapopulations. <i>The American Naturalist</i>. 2025;205(6):617-636. doi:<a href=\"https://doi.org/10.1086/735562\">10.1086/735562</a>","short":"O.O. Olusanya, K. Khudiakova, H. Sachdeva, The American Naturalist 205 (2025) 617–636.","apa":"Olusanya, O. O., Khudiakova, K., &#38; Sachdeva, H. (2025). Genetic load, eco-evolutionary feedback, and extinction in metapopulations. <i>The American Naturalist</i>. University of Chicago Press. <a href=\"https://doi.org/10.1086/735562\">https://doi.org/10.1086/735562</a>","ieee":"O. O. Olusanya, K. Khudiakova, and H. Sachdeva, “Genetic load, eco-evolutionary feedback, and extinction in metapopulations,” <i>The American Naturalist</i>, vol. 205, no. 6. University of Chicago Press, pp. 617–636, 2025.","chicago":"Olusanya, Oluwafunmilola O, Kseniia Khudiakova, and Himani Sachdeva. “Genetic Load, Eco-Evolutionary Feedback, and Extinction in Metapopulations.” <i>The American Naturalist</i>. University of Chicago Press, 2025. <a href=\"https://doi.org/10.1086/735562\">https://doi.org/10.1086/735562</a>."},"related_material":{"record":[{"id":"14732","status":"public","relation":"earlier_version"}]},"publication_identifier":{"eissn":["1537-5323"],"issn":["0003-0147"]},"volume":205,"OA_type":"green","OA_place":"repository","quality_controlled":"1","acknowledgement":"This research was partially funded by the Austrian Science Fund (FWF P-32896B) and DOC Fellowships of the Austrian Academy of Sciences: grants 26380 (O.O.) and 26293 (K.K.). We thank Nick Barton for useful comments on the chapter in O.O.’s thesis that led to this article.","date_published":"2025-06-01T00:00:00Z","day":"01","external_id":{"pmid":["40446297 "]},"fulldoi":"https://doi.org/10.1086/735562","language":[{"iso":"eng"}],"title":"Genetic load, eco-evolutionary feedback, and extinction in metapopulations","abstract":[{"lang":"eng","text":"Habitat fragmentation poses a significant risk to population survival, causing both demographic stochasticity and genetic drift within local populations to increase, thereby increasing genetic load. Higher load causes population numbers to decline, which reduces the efficiency of selection and further increases load, resulting in a positive feedback that may drive entire populations to extinction. Here, we investigate this eco-evolutionary feedback in a metapopulation consisting of local demes connected via migration, with individuals subject to deleterious mutation at a large number of loci. We first analyze the determinants of load under soft selection, where population sizes are fixed, and then build on this to understand hard selection, where population sizes and load coevolve. We show that under soft selection, very little gene flow (less than one migrant per generation) is enough to prevent fixation of deleterious alleles. By contrast, much higher levels of migration are required to mitigate load and prevent extinction when selection is hard, with critical migration thresholds for metapopulation persistence increasing sharply as the genome-wide deleterious mutation rate becomes comparable to the baseline population growth rate. Moreover, critical migration thresholds are highest if deleterious mutations have intermediate selection coefficients but lower if alleles are predominantly recessive rather than additive (due to more efficient purging of recessive load within local populations). Our analysis is based on a combination of analytical approximations and simulations, allowing for a more comprehensive understanding of the factors influencing load and extinction in fragmented populations."}],"pmid":1,"page":"617-636","date_updated":"2026-04-07T08:45:14Z","project":[{"_id":"c08d3278-5a5b-11eb-8a69-fdb09b55f4b8","name":"Causes and consequences of population fragmentation","grant_number":"P32896"},{"_id":"34c872fe-11ca-11ed-8bc3-8534b82131e6","name":"Polygenic Adaptation in a Metapopulation","grant_number":"26380"},{"grant_number":"26293","_id":"34d33d68-11ca-11ed-8bc3-ec13763c0ca8","name":"The impact of deleterious mutations on small populations"}],"type":"journal_article","status":"public","_id":"21322","publisher":"University of Chicago Press","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","doi":"10.1086/735562"},{"publication_status":"published","article_type":"original","author":[{"first_name":"Kseniia","full_name":"Khudiakova, Kseniia","orcid":"0000-0002-6246-1465","id":"4E6DC800-AE37-11E9-AC72-31CAE5697425","last_name":"Khudiakova"},{"last_name":"Maas","id":"4C5696CE-F248-11E8-B48F-1D18A9856A87","first_name":"Jan","orcid":"0000-0002-0845-1338","full_name":"Maas, Jan"},{"id":"d3ac8ac6-dc8d-11ea-abe3-e2a9628c4c3c","full_name":"Pedrotti, Francesco","first_name":"Francesco","last_name":"Pedrotti"}],"issue":"3","oa_version":"Preprint","intvolume":"        35","main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2402.04151","open_access":"1"}],"month":"06","article_processing_charge":"No","year":"2025","oa":1,"publication":"The Annals of Applied Probability","scopus_import":"1","department":[{"_id":"JaMa"}],"date_created":"2025-07-21T08:13:54Z","related_material":{"record":[{"status":"public","relation":"earlier_version","id":"17352"}]},"corr_author":"1","citation":{"chicago":"Khudiakova, Kseniia, Jan Maas, and Francesco Pedrotti. “L∞-Optimal Transport of Anisotropic Log-Concave Measures and Exponential Convergence in Fisher’s Infinitesimal Model.” <i>The Annals of Applied Probability</i>. Institute of Mathematical Statistics, 2025. <a href=\"https://doi.org/10.1214/25-aap2162\">https://doi.org/10.1214/25-aap2162</a>.","apa":"Khudiakova, K., Maas, J., &#38; Pedrotti, F. (2025). L∞-optimal transport of anisotropic log-concave measures and exponential convergence in Fisher’s infinitesimal model. <i>The Annals of Applied Probability</i>. Institute of Mathematical Statistics. <a href=\"https://doi.org/10.1214/25-aap2162\">https://doi.org/10.1214/25-aap2162</a>","ieee":"K. Khudiakova, J. Maas, and F. Pedrotti, “L∞-optimal transport of anisotropic log-concave measures and exponential convergence in Fisher’s infinitesimal model,” <i>The Annals of Applied Probability</i>, vol. 35, no. 3. Institute of Mathematical Statistics, pp. 1913–1940, 2025.","short":"K. Khudiakova, J. Maas, F. Pedrotti, The Annals of Applied Probability 35 (2025) 1913–1940.","ama":"Khudiakova K, Maas J, Pedrotti F. L∞-optimal transport of anisotropic log-concave measures and exponential convergence in Fisher’s infinitesimal model. <i>The Annals of Applied Probability</i>. 2025;35(3):1913-1940. doi:<a href=\"https://doi.org/10.1214/25-aap2162\">10.1214/25-aap2162</a>","mla":"Khudiakova, Kseniia, et al. “L∞-Optimal Transport of Anisotropic Log-Concave Measures and Exponential Convergence in Fisher’s Infinitesimal Model.” <i>The Annals of Applied Probability</i>, vol. 35, no. 3, Institute of Mathematical Statistics, 2025, pp. 1913–40, doi:<a href=\"https://doi.org/10.1214/25-aap2162\">10.1214/25-aap2162</a>.","ista":"Khudiakova K, Maas J, Pedrotti F. 2025. L∞-optimal transport of anisotropic log-concave measures and exponential convergence in Fisher’s infinitesimal model. The Annals of Applied Probability. 35(3), 1913–1940."},"OA_type":"green","OA_place":"repository","quality_controlled":"1","arxiv":1,"volume":35,"publication_identifier":{"issn":["1050-5164"]},"acknowledgement":"This research was funded in part by the Austrian Science Fund (FWF) project 10.55776/F65 and the Austrian Academy of Science, DOC fellowship nr. 26293.","day":"01","date_published":"2025-06-01T00:00:00Z","isi":1,"fulldoi":"https://doi.org/10.1214/25-aap2162","language":[{"iso":"eng"}],"external_id":{"isi":["001523520000012"],"arxiv":["2402.04151"]},"abstract":[{"lang":"eng","text":"We prove upper bounds on the L∞-Wasserstein distance from optimal transport between strongly log-concave probability densities and log-Lipschitz perturbations. In the simplest setting, such a bound amounts to a transport-information inequality involving the L∞-Wasserstein metric and the relative L∞-Fisher information. We show that this inequality can be sharpened significantly in situations where the involved densities are anisotropic. Our proof is based on probabilistic techniques using Langevin dynamics. As an application of these results, we obtain sharp exponential rates of convergence in Fisher’s infinitesimal model from quantitative genetics, generalising recent results by Calvez, Poyato, and Santambrogio in dimension 1 to arbitrary dimensions."}],"title":"L∞-optimal transport of anisotropic log-concave measures and exponential convergence in Fisher’s infinitesimal model","date_updated":"2025-09-30T14:12:48Z","page":"1913-1940","project":[{"grant_number":"F6504","_id":"fc31cba2-9c52-11eb-aca3-ff467d239cd2","name":"Taming Complexity in Partial Differential Systems"},{"name":"The impact of deleterious mutations on small populations","_id":"34d33d68-11ca-11ed-8bc3-ec13763c0ca8","grant_number":"26293"}],"type":"journal_article","status":"public","_id":"20050","doi":"10.1214/25-aap2162","publisher":"Institute of Mathematical Statistics","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345"},{"acknowledgement":"This work was supported by the Austrian Academy of Science, DOC fellowship No 26293 (K.K.) and the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 101034413 (J.T.). Simulations were performed on the ISTA High-performance Computing Cluster.","ec_funded":1,"OA_type":"green","citation":{"ista":"Khudiakova K, Boenkost F, Tourniaire JN. Genealogies under purifying selection. bioRxiv, <a href=\"https://doi.org/10.1101/2024.10.15.618444\">10.1101/2024.10.15.618444</a>.","mla":"Khudiakova, Kseniia, et al. “Genealogies under Purifying Selection.” <i>BioRxiv</i>, doi:<a href=\"https://doi.org/10.1101/2024.10.15.618444\">10.1101/2024.10.15.618444</a>.","ama":"Khudiakova K, Boenkost F, Tourniaire JN. Genealogies under purifying selection. <i>bioRxiv</i>. doi:<a href=\"https://doi.org/10.1101/2024.10.15.618444\">10.1101/2024.10.15.618444</a>","short":"K. Khudiakova, F. Boenkost, J.N. Tourniaire, BioRxiv (n.d.).","ieee":"K. Khudiakova, F. Boenkost, and J. N. Tourniaire, “Genealogies under purifying selection,” <i>bioRxiv</i>. .","apa":"Khudiakova, K., Boenkost, F., &#38; Tourniaire, J. N. (n.d.). Genealogies under purifying selection. <i>bioRxiv</i>. <a href=\"https://doi.org/10.1101/2024.10.15.618444\">https://doi.org/10.1101/2024.10.15.618444</a>","chicago":"Khudiakova, Kseniia, Florin Boenkost, and Julie N Tourniaire. “Genealogies under Purifying Selection.” <i>BioRxiv</i>, n.d. <a href=\"https://doi.org/10.1101/2024.10.15.618444\">https://doi.org/10.1101/2024.10.15.618444</a>."},"corr_author":"1","related_material":{"record":[{"relation":"dissertation_contains","status":"public","id":"21918"}]},"date_created":"2026-06-09T12:14:08Z","department":[{"_id":"NiBa"},{"_id":"JaMa"}],"publication":"bioRxiv","year":"2024","oa":1,"article_processing_charge":"No","month":"10","main_file_link":[{"url":"https://doi.org/10.1101/2024.10.15.618444","open_access":"1"}],"oa_version":"Preprint","author":[{"last_name":"Khudiakova","id":"4E6DC800-AE37-11E9-AC72-31CAE5697425","orcid":"0000-0002-6246-1465","full_name":"Khudiakova, Kseniia","first_name":"Kseniia"},{"first_name":"Florin","full_name":"Boenkost, Florin","last_name":"Boenkost"},{"last_name":"Tourniaire","first_name":"Julie N","full_name":"Tourniaire, Julie N","id":"5dc06dd8-8e51-11ec-9170-8d9c450cc216"}],"publication_status":"draft","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","doi":"10.1101/2024.10.15.618444","_id":"21967","status":"public","project":[{"grant_number":"26293","_id":"34d33d68-11ca-11ed-8bc3-ec13763c0ca8","name":"The impact of deleterious mutations on small populations"},{"_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","call_identifier":"H2020","name":"IST-BRIDGE: International postdoctoral program","grant_number":"101034413"}],"type":"preprint","date_updated":"2026-06-12T12:43:34Z","title":"Genealogies under purifying selection","abstract":[{"lang":"eng","text":"Selection against deleterious mutations, called purifying selection, plays a central role in evolution and acts in all populations. It is known that the genetic patterns observed in genomic regions undergoing purifying selection differ from those resulting from neutral evolution. However, a comprehensive understanding of the underlying mechanisms shaping those patterns is still lacking.\r\n\r\nIn the present work, we use simulations combined with a genealogical approach to identify the effect of purifying selection on the ancestry and thus on the genetic diversity. Our analysis relies on the postulate that the genealogy belongs to the universality class of Beta-coalescents. Under this assumption, we derive statistics measuring the distortion of the genealogy. This approach allows us to consider a wide range of regimes (i.e. arbitrary selection and mutation strengths) and uncover a rich phase diagram. We find that, for strong selection, the limiting genealogy is given by Kingman’s coalescent on a polynomial timescale. As selection gets weaker, Muller’s ratchet starts operating, setting off the emergence of multiple mergers in the genealogical structures. Our results show that while multiple-merger coalescents are often interpreted as the signature of selective sweeps in rapidly adapting populations, these structures can also appear in the context of Muller’s ratchet."}],"tmp":{"name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","image":"/images/cc_by_nc_nd.png"},"language":[{"iso":"eng"}],"fulldoi":"https://doi.org/10.1101/2024.10.15.618444","date_published":"2024-10-18T00:00:00Z","day":"18"},{"publication_status":"draft","author":[{"last_name":"Khudiakova","first_name":"Kseniia","full_name":"Khudiakova, Kseniia","orcid":"0000-0002-6246-1465","id":"4E6DC800-AE37-11E9-AC72-31CAE5697425"},{"last_name":"Maas","full_name":"Maas, Jan","orcid":"0000-0002-0845-1338","first_name":"Jan","id":"4C5696CE-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Pedrotti","id":"d3ac8ac6-dc8d-11ea-abe3-e2a9628c4c3c","first_name":"Francesco","full_name":"Pedrotti, Francesco"}],"article_processing_charge":"No","year":"2024","oa":1,"month":"02","main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2402.04151","open_access":"1"}],"oa_version":"Preprint","corr_author":"1","citation":{"ista":"Khudiakova K, Maas J, Pedrotti F. L∞-optimal transport of anisotropic log-concave measures and exponential convergence in Fisher’s infinitesimal model. arXiv, 2402.04151.","mla":"Khudiakova, Kseniia, et al. “L∞-Optimal Transport of Anisotropic Log-Concave Measures and Exponential Convergence in Fisher’s Infinitesimal Model.” <i>ArXiv</i>, 2402.04151, doi:<a href=\"https://doi.org/10.48550/arXiv.2402.04151\">10.48550/arXiv.2402.04151</a>.","ama":"Khudiakova K, Maas J, Pedrotti F. L∞-optimal transport of anisotropic log-concave measures and exponential convergence in Fisher’s infinitesimal model. <i>arXiv</i>. doi:<a href=\"https://doi.org/10.48550/arXiv.2402.04151\">10.48550/arXiv.2402.04151</a>","ieee":"K. Khudiakova, J. Maas, and F. Pedrotti, “L∞-optimal transport of anisotropic log-concave measures and exponential convergence in Fisher’s infinitesimal model,” <i>arXiv</i>. .","apa":"Khudiakova, K., Maas, J., &#38; Pedrotti, F. (n.d.). L∞-optimal transport of anisotropic log-concave measures and exponential convergence in Fisher’s infinitesimal model. <i>arXiv</i>. <a href=\"https://doi.org/10.48550/arXiv.2402.04151\">https://doi.org/10.48550/arXiv.2402.04151</a>","short":"K. Khudiakova, J. Maas, F. Pedrotti, ArXiv (n.d.).","chicago":"Khudiakova, Kseniia, Jan Maas, and Francesco Pedrotti. “L∞-Optimal Transport of Anisotropic Log-Concave Measures and Exponential Convergence in Fisher’s Infinitesimal Model.” <i>ArXiv</i>, n.d. <a href=\"https://doi.org/10.48550/arXiv.2402.04151\">https://doi.org/10.48550/arXiv.2402.04151</a>."},"related_material":{"record":[{"id":"20050","relation":"later_version","status":"public"},{"status":"public","relation":"dissertation_contains","id":"17336"}]},"department":[{"_id":"JaMa"}],"date_created":"2024-07-31T08:07:40Z","publication":"arXiv","article_number":"2402.04151","arxiv":1,"OA_place":"repository","external_id":{"arxiv":["2402.04151"]},"fulldoi":"https://doi.org/10.48550/arXiv.2402.04151","language":[{"iso":"eng"}],"date_published":"2024-02-07T00:00:00Z","day":"07","date_updated":"2026-04-07T13:00:02Z","title":"L∞-optimal transport of anisotropic log-concave measures and exponential convergence in Fisher's infinitesimal model","abstract":[{"text":"We prove upper bounds on the $L^\\infty$-Wasserstein distance from optimal\r\ntransport between strongly log-concave probability densities and log-Lipschitz\r\nperturbations. In the simplest setting, such a bound amounts to a\r\ntransport-information inequality involving the $L^\\infty$-Wasserstein metric\r\nand the relative $L^\\infty$-Fisher information. We show that this inequality\r\ncan be sharpened significantly in situations where the involved densities are\r\nanisotropic. Our proof is based on probabilistic techniques using Langevin\r\ndynamics. As an application of these results, we obtain sharp exponential rates\r\nof convergence in Fisher's infinitesimal model from quantitative genetics,\r\ngeneralising recent results by Calvez, Poyato, and Santambrogio in dimension 1\r\nto arbitrary dimensions.","lang":"eng"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","doi":"10.48550/arXiv.2402.04151","project":[{"name":"Taming Complexity in Partial Differential Systems","_id":"fc31cba2-9c52-11eb-aca3-ff467d239cd2","grant_number":"F6504"},{"grant_number":"26293","_id":"34d33d68-11ca-11ed-8bc3-ec13763c0ca8","name":"The impact of deleterious mutations on small populations"}],"type":"preprint","_id":"17352","status":"public"},{"month":"12","oa_version":"Preprint","main_file_link":[{"open_access":"1","url":"https://www.biorxiv.org/content/10.1101/2023.12.02.569702v1"}],"tmp":{"name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","image":"/images/cc_by_nc_nd.png"},"article_processing_charge":"No","year":"2023","oa":1,"day":"04","date_published":"2023-12-04T00:00:00Z","fulldoi":"https://doi.org/10.1101/2023.12.02.569702","publication_status":"draft","language":[{"iso":"eng"}],"author":[{"full_name":"Olusanya, Oluwafunmilola O","orcid":"0000-0003-1971-8314","first_name":"Oluwafunmilola O","id":"41AD96DC-F248-11E8-B48F-1D18A9856A87","last_name":"Olusanya"},{"first_name":"Kseniia","orcid":"0000-0002-6246-1465","full_name":"Khudiakova, Kseniia","id":"4E6DC800-AE37-11E9-AC72-31CAE5697425","last_name":"Khudiakova"},{"last_name":"Sachdeva","full_name":"Sachdeva, Himani","first_name":"Himani","id":"42377A0A-F248-11E8-B48F-1D18A9856A87"}],"project":[{"name":"Causes and consequences of population fragmentation","_id":"c08d3278-5a5b-11eb-8a69-fdb09b55f4b8","grant_number":"P32896"},{"name":"The impact of deleterious mutations on small populations","_id":"34d33d68-11ca-11ed-8bc3-ec13763c0ca8","grant_number":"26293"},{"grant_number":"26380","_id":"34c872fe-11ca-11ed-8bc3-8534b82131e6","name":"Polygenic Adaptation in a Metapopulation"}],"type":"preprint","_id":"14732","status":"public","OA_place":"repository","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","doi":"10.1101/2023.12.02.569702","department":[{"_id":"NiBa"},{"_id":"JaMa"}],"title":"Genetic load, eco-evolutionary feedback and extinction in a metapopulation","date_created":"2024-01-04T09:35:54Z","publication":"bioRxiv","abstract":[{"text":"Fragmented landscapes pose a significant threat to the persistence of species as they are highly susceptible to heightened risk of extinction due to the combined effects of genetic and demographic factors such as genetic drift and demographic stochasticity. This paper explores the intricate interplay between genetic load and extinction risk within metapopulations with a focus on understanding the impact of eco-evolutionary feedback mechanisms. We distinguish between two models of selection: soft selection, characterised by subpopulations maintaining carrying capacity despite load, and hard selection, where load can significantly affect population size. Within the soft selection framework, we investigate the impact of gene flow on genetic load at a single locus, while also considering the effect of selection strength and dominance coefficient. We subsequently build on this to examine how gene flow influences both population size and load under hard selection as well as identify critical thresholds for metapopulation persistence. Our analysis employs the diffusion, semi-deterministic and effective migration approximations. Our findings reveal that under soft selection, even modest levels of migration can significantly alleviate the burden of load. In sharp contrast, with hard selection, a much higher degree of gene flow is required to mitigate load and prevent the collapse of the metapopulation. Overall, this study sheds light into the crucial role migration plays in shaping the dynamics of genetic load and extinction risk in fragmented landscapes, offering valuable insights for conservation strategies and the preservation of diversity in a changing world.","lang":"eng"}],"corr_author":"1","citation":{"chicago":"Olusanya, Oluwafunmilola O, Kseniia Khudiakova, and Himani Sachdeva. “Genetic Load, Eco-Evolutionary Feedback and Extinction in a Metapopulation.” <i>BioRxiv</i>, n.d. <a href=\"https://doi.org/10.1101/2023.12.02.569702\">https://doi.org/10.1101/2023.12.02.569702</a>.","short":"O.O. Olusanya, K. Khudiakova, H. Sachdeva, BioRxiv (n.d.).","apa":"Olusanya, O. O., Khudiakova, K., &#38; Sachdeva, H. (n.d.). Genetic load, eco-evolutionary feedback and extinction in a metapopulation. <i>bioRxiv</i>. <a href=\"https://doi.org/10.1101/2023.12.02.569702\">https://doi.org/10.1101/2023.12.02.569702</a>","ieee":"O. O. Olusanya, K. Khudiakova, and H. Sachdeva, “Genetic load, eco-evolutionary feedback and extinction in a metapopulation,” <i>bioRxiv</i>. .","mla":"Olusanya, Oluwafunmilola O., et al. “Genetic Load, Eco-Evolutionary Feedback and Extinction in a Metapopulation.” <i>BioRxiv</i>, doi:<a href=\"https://doi.org/10.1101/2023.12.02.569702\">10.1101/2023.12.02.569702</a>.","ama":"Olusanya OO, Khudiakova K, Sachdeva H. Genetic load, eco-evolutionary feedback and extinction in a metapopulation. <i>bioRxiv</i>. doi:<a href=\"https://doi.org/10.1101/2023.12.02.569702\">10.1101/2023.12.02.569702</a>","ista":"Olusanya OO, Khudiakova K, Sachdeva H. Genetic load, eco-evolutionary feedback and extinction in a metapopulation. bioRxiv, <a href=\"https://doi.org/10.1101/2023.12.02.569702\">10.1101/2023.12.02.569702</a>."},"related_material":{"record":[{"relation":"later_version","status":"public","id":"21322"},{"id":"14711","relation":"dissertation_contains","status":"public"}]},"date_updated":"2026-04-07T12:54:28Z"},{"pmid":1,"license":"https://creativecommons.org/licenses/by/4.0/","date_updated":"2026-09-30T22:31:21Z","title":"Slower-X: Reduced efficiency of selection in the early stages of X chromosome evolution","file_date_updated":"2023-08-16T11:43:33Z","abstract":[{"lang":"eng","text":"Differentiated X chromosomes are expected to have higher rates of adaptive divergence than autosomes, if new beneficial mutations are recessive (the “faster-X effect”), largely because these mutations are immediately exposed to selection in males. The evolution of X chromosomes after they stop recombining in males, but before they become hemizygous, has not been well explored theoretically. We use the diffusion approximation to infer substitution rates of beneficial and deleterious mutations under such a scenario. Our results show that selection is less efficient on diploid X loci than on autosomal and hemizygous X loci under a wide range of parameters. This “slower-X” effect is stronger for genes affecting primarily (or only) male fitness, and for sexually antagonistic genes. These unusual dynamics suggest that some of the peculiar features of X chromosomes, such as the differential accumulation of genes with sex-specific functions, may start arising earlier than previously appreciated."}],"publisher":"Oxford University Press","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","doi":"10.1093/evlett/qrac004","type":"journal_article","project":[{"name":"Optimal Transport and Stochastic Dynamics","call_identifier":"H2020","_id":"256E75B8-B435-11E9-9278-68D0E5697425","grant_number":"716117"},{"grant_number":"715257","call_identifier":"H2020","name":"Prevalence and Influence of Sexual Antagonism on Genome Evolution","_id":"250BDE62-B435-11E9-9278-68D0E5697425"}],"_id":"12521","status":"public","external_id":{"isi":["001021692200001"],"pmid":["37065438"]},"file":[{"file_id":"14068","access_level":"open_access","content_type":"application/pdf","file_name":"2023_EvLetters_Mrnjavac.pdf","date_updated":"2023-08-16T11:43:33Z","checksum":"a240a041cb9b9b7c8ba93a4706674a3f","file_size":2592189,"creator":"dernst","success":1,"date_created":"2023-08-16T11:43:33Z","relation":"main_file"}],"fulldoi":"https://doi.org/10.1093/evlett/qrac004","isi":1,"language":[{"iso":"eng"}],"day":"01","date_published":"2023-02-01T00:00:00Z","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)"},"keyword":["Genetics","Ecology","Evolution","Behavior and Systematics"],"corr_author":"1","citation":{"chicago":"Mrnjavac, Andrea, Kseniia Khudiakova, Nicholas H Barton, and Beatriz Vicoso. “Slower-X: Reduced Efficiency of Selection in the Early Stages of X Chromosome Evolution.” <i>Evolution Letters</i>. Oxford University Press, 2023. <a href=\"https://doi.org/10.1093/evlett/qrac004\">https://doi.org/10.1093/evlett/qrac004</a>.","short":"A. Mrnjavac, K. Khudiakova, N.H. Barton, B. Vicoso, Evolution Letters 7 (2023).","apa":"Mrnjavac, A., Khudiakova, K., Barton, N. H., &#38; Vicoso, B. (2023). Slower-X: Reduced efficiency of selection in the early stages of X chromosome evolution. <i>Evolution Letters</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/evlett/qrac004\">https://doi.org/10.1093/evlett/qrac004</a>","ieee":"A. Mrnjavac, K. Khudiakova, N. H. Barton, and B. Vicoso, “Slower-X: Reduced efficiency of selection in the early stages of X chromosome evolution,” <i>Evolution Letters</i>, vol. 7, no. 1. Oxford University Press, 2023.","mla":"Mrnjavac, Andrea, et al. “Slower-X: Reduced Efficiency of Selection in the Early Stages of X Chromosome Evolution.” <i>Evolution Letters</i>, vol. 7, no. 1, qrac004, Oxford University Press, 2023, doi:<a href=\"https://doi.org/10.1093/evlett/qrac004\">10.1093/evlett/qrac004</a>.","ama":"Mrnjavac A, Khudiakova K, Barton NH, Vicoso B. Slower-X: Reduced efficiency of selection in the early stages of X chromosome evolution. <i>Evolution Letters</i>. 2023;7(1). doi:<a href=\"https://doi.org/10.1093/evlett/qrac004\">10.1093/evlett/qrac004</a>","ista":"Mrnjavac A, Khudiakova K, Barton NH, Vicoso B. 2023. Slower-X: Reduced efficiency of selection in the early stages of X chromosome evolution. Evolution Letters. 7(1), qrac004."},"related_material":{"record":[{"id":"18531","status":"public","relation":"dissertation_contains"}]},"has_accepted_license":"1","scopus_import":"1","department":[{"_id":"GradSch"},{"_id":"BeVi"}],"date_created":"2023-02-06T13:59:12Z","publication":"Evolution Letters","acknowledgement":"We thank the Vicoso and Barton groups and ISTA Scientific Computing Unit. We also thank two anonymous reviewers for their valuable comments. This work was supported by the European Research Council under the European Union’s Horizon 2020 research and innovation program (grant agreements no. 715257 and no. 716117).","article_number":"qrac004","volume":7,"publication_identifier":{"issn":["2056-3744"]},"ec_funded":1,"quality_controlled":"1","article_type":"original","publication_status":"published","author":[{"last_name":"Mrnjavac","first_name":"Andrea","full_name":"Mrnjavac, Andrea","id":"353FAC84-AE61-11E9-8BFC-00D3E5697425"},{"id":"4E6DC800-AE37-11E9-AC72-31CAE5697425","first_name":"Kseniia","orcid":"0000-0002-6246-1465","full_name":"Khudiakova, Kseniia","last_name":"Khudiakova"},{"orcid":"0000-0002-8548-5240","full_name":"Barton, Nicholas H","first_name":"Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","last_name":"Barton"},{"last_name":"Vicoso","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","full_name":"Vicoso, Beatriz","orcid":"0000-0002-4579-8306","first_name":"Beatriz"}],"ddc":["570"],"article_processing_charge":"Yes (via OA deal)","year":"2023","oa":1,"month":"02","issue":"1","oa_version":"Published Version","intvolume":"         7"},{"acknowledgement":"We are grateful to Herbert Edelsbrunner and Jeferson Zapata for helpful discussions. Open access funding provided by Austrian Science Fund (FWF). Partially supported by the ERC Consolidator (771209–CharFL) and the FWF Austrian Science Fund (I5127-B) grants to FAK.","article_number":"74","volume":84,"publication_identifier":{"issn":["0092-8240"],"eissn":["1522-9602"]},"ec_funded":1,"quality_controlled":"1","corr_author":"1","citation":{"ista":"Saona Urmeneta RJ, Kondrashov F, Khudiakova K. 2022. Relation between the number of peaks and the number of reciprocal sign epistatic interactions. Bulletin of Mathematical Biology. 84(8), 74.","ama":"Saona Urmeneta RJ, Kondrashov F, Khudiakova K. Relation between the number of peaks and the number of reciprocal sign epistatic interactions. <i>Bulletin of Mathematical Biology</i>. 2022;84(8). doi:<a href=\"https://doi.org/10.1007/s11538-022-01029-z\">10.1007/s11538-022-01029-z</a>","mla":"Saona Urmeneta, Raimundo J., et al. “Relation between the Number of Peaks and the Number of Reciprocal Sign Epistatic Interactions.” <i>Bulletin of Mathematical Biology</i>, vol. 84, no. 8, 74, Springer Nature, 2022, doi:<a href=\"https://doi.org/10.1007/s11538-022-01029-z\">10.1007/s11538-022-01029-z</a>.","short":"R.J. Saona Urmeneta, F. Kondrashov, K. Khudiakova, Bulletin of Mathematical Biology 84 (2022).","ieee":"R. J. Saona Urmeneta, F. Kondrashov, and K. Khudiakova, “Relation between the number of peaks and the number of reciprocal sign epistatic interactions,” <i>Bulletin of Mathematical Biology</i>, vol. 84, no. 8. Springer Nature, 2022.","apa":"Saona Urmeneta, R. J., Kondrashov, F., &#38; Khudiakova, K. (2022). Relation between the number of peaks and the number of reciprocal sign epistatic interactions. <i>Bulletin of Mathematical Biology</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s11538-022-01029-z\">https://doi.org/10.1007/s11538-022-01029-z</a>","chicago":"Saona Urmeneta, Raimundo J, Fyodor Kondrashov, and Kseniia Khudiakova. “Relation between the Number of Peaks and the Number of Reciprocal Sign Epistatic Interactions.” <i>Bulletin of Mathematical Biology</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1007/s11538-022-01029-z\">https://doi.org/10.1007/s11538-022-01029-z</a>."},"related_material":{"record":[{"relation":"dissertation_contains","status":"public","id":"21918"}],"link":[{"url":"https://doi.org/10.1007/s11538-022-01118-z","relation":"erratum"}]},"has_accepted_license":"1","department":[{"_id":"GradSch"},{"_id":"NiBa"},{"_id":"JaMa"}],"scopus_import":"1","date_created":"2022-06-17T16:16:15Z","publication":"Bulletin of Mathematical Biology","article_processing_charge":"Yes (via OA deal)","year":"2022","oa":1,"month":"06","intvolume":"        84","oa_version":"Published Version","issue":"8","article_type":"original","publication_status":"published","author":[{"id":"BD1DF4C4-D767-11E9-B658-BC13E6697425","first_name":"Raimundo J","orcid":"0000-0001-5103-038X","full_name":"Saona Urmeneta, Raimundo J","last_name":"Saona Urmeneta"},{"first_name":"Fyodor","orcid":"0000-0001-8243-4694","full_name":"Kondrashov, Fyodor","id":"44FDEF62-F248-11E8-B48F-1D18A9856A87","last_name":"Kondrashov"},{"first_name":"Kseniia","orcid":"0000-0002-6246-1465","full_name":"Khudiakova, Kseniia","id":"4E6DC800-AE37-11E9-AC72-31CAE5697425","last_name":"Khudiakova"}],"ddc":["510","570"],"publisher":"Springer Nature","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","doi":"10.1007/s11538-022-01029-z","project":[{"_id":"26580278-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"Characterizing the fitness landscape on population and global scales","grant_number":"771209"},{"_id":"34e076d6-11ca-11ed-8bc3-aec76c41a181","name":"Evolutionary analysis of gene regulation","grant_number":"I05127"}],"type":"journal_article","status":"public","_id":"11447","pmid":1,"date_updated":"2026-06-12T12:43:34Z","title":"Relation between the number of peaks and the number of reciprocal sign epistatic interactions","file_date_updated":"2022-06-20T07:51:32Z","abstract":[{"lang":"eng","text":"Empirical essays of fitness landscapes suggest that they may be rugged, that is having multiple fitness peaks. Such fitness landscapes, those that have multiple peaks, necessarily have special local structures, called reciprocal sign epistasis (Poelwijk et al. in J Theor Biol 272:141–144, 2011). Here, we investigate the quantitative relationship between the number of fitness peaks and the number of reciprocal sign epistatic interactions. Previously, it has been shown (Poelwijk et al. in J Theor Biol 272:141–144, 2011) that pairwise reciprocal sign epistasis is a necessary but not sufficient condition for the existence of multiple peaks. Applying discrete Morse theory, which to our knowledge has never been used in this context, we extend this result by giving the minimal number of reciprocal sign epistatic interactions required to create a given number of peaks."}],"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)"},"keyword":["Computational Theory and Mathematics","General Agricultural and Biological Sciences","Pharmacology","General Environmental Science","General Biochemistry","Genetics and Molecular Biology","General Mathematics","Immunology","General Neuroscience"],"external_id":{"pmid":["35713756"],"isi":["000812509800001"]},"isi":1,"fulldoi":"https://doi.org/10.1007/s11538-022-01029-z","file":[{"content_type":"application/pdf","file_name":"2022_BulletinMathBiology_Saona.pdf","access_level":"open_access","file_id":"11455","relation":"main_file","date_created":"2022-06-20T07:51:32Z","success":1,"creator":"dernst","file_size":463025,"date_updated":"2022-06-20T07:51:32Z","checksum":"05a1fe7d10914a00c2bca9b447993a65"}],"language":[{"iso":"eng"}],"day":"17","date_published":"2022-06-17T00:00:00Z"},{"date_published":"2021-04-24T00:00:00Z","day":"24","language":[{"iso":"eng"}],"fulldoi":"https://doi.org/10.1016/j.jtbi.2021.110729","isi":1,"external_id":{"pmid":["33901507"],"isi":["000659161500002"]},"keyword":["General Biochemistry","Genetics and Molecular Biology","Modelling and Simulation","Statistics and Probability","General Immunology and Microbiology","Applied Mathematics","General Agricultural and Biological Sciences","General Medicine"],"abstract":[{"text":"We report the complete analysis of a deterministic model of deleterious mutations and negative selection against them at two haploid loci without recombination. As long as mutation is a weaker force than selection, mutant alleles remain rare at the only stable equilibrium, and otherwise, a variety of dynamics are possible. If the mutation-free genotype is absent, generally the only stable equilibrium is the one that corresponds to fixation of the mutant allele at the locus where it is less deleterious. This result suggests that fixation of a deleterious allele that follows a click of the Muller’s ratchet is governed by natural selection, instead of random drift.","lang":"eng"}],"title":"Two linked loci under mutation-selection balance and Muller’s ratchet","date_updated":"2026-07-06T12:58:31Z","pmid":1,"status":"public","_id":"9387","type":"journal_article","doi":"10.1016/j.jtbi.2021.110729","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"Elsevier","author":[{"last_name":"Khudiakova","id":"4E6DC800-AE37-11E9-AC72-31CAE5697425","first_name":"Kseniia","full_name":"Khudiakova, Kseniia","orcid":"0000-0002-6246-1465"},{"first_name":"Tatiana Yu.","full_name":"Neretina, Tatiana Yu.","last_name":"Neretina"},{"last_name":"Kondrashov","first_name":"Alexey S.","full_name":"Kondrashov, Alexey S."}],"publication_status":"published","article_type":"original","oa_version":"Preprint","main_file_link":[{"open_access":"1","url":"https://www.biorxiv.org/content/10.1101/477489v1"}],"intvolume":"       524","month":"04","oa":1,"year":"2021","article_processing_charge":"No","publication":"Journal of Theoretical Biology","date_created":"2021-05-12T05:58:42Z","das_tickbox":"1","department":[{"_id":"GradSch"}],"scopus_import":"1","citation":{"ista":"Khudiakova K, Neretina TY, Kondrashov AS. 2021. Two linked loci under mutation-selection balance and Muller’s ratchet. Journal of Theoretical Biology. 524, 110729.","ama":"Khudiakova K, Neretina TY, Kondrashov AS. Two linked loci under mutation-selection balance and Muller’s ratchet. <i>Journal of Theoretical Biology</i>. 2021;524. doi:<a href=\"https://doi.org/10.1016/j.jtbi.2021.110729\">10.1016/j.jtbi.2021.110729</a>","mla":"Khudiakova, Kseniia, et al. “Two Linked Loci under Mutation-Selection Balance and Muller’s Ratchet.” <i>Journal of Theoretical Biology</i>, vol. 524, 110729, Elsevier, 2021, doi:<a href=\"https://doi.org/10.1016/j.jtbi.2021.110729\">10.1016/j.jtbi.2021.110729</a>.","ieee":"K. Khudiakova, T. Y. Neretina, and A. S. Kondrashov, “Two linked loci under mutation-selection balance and Muller’s ratchet,” <i>Journal of Theoretical Biology</i>, vol. 524. Elsevier, 2021.","apa":"Khudiakova, K., Neretina, T. Y., &#38; Kondrashov, A. S. (2021). Two linked loci under mutation-selection balance and Muller’s ratchet. <i>Journal of Theoretical Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.jtbi.2021.110729\">https://doi.org/10.1016/j.jtbi.2021.110729</a>","short":"K. Khudiakova, T.Y. Neretina, A.S. Kondrashov, Journal of Theoretical Biology 524 (2021).","chicago":"Khudiakova, Kseniia, Tatiana Yu. Neretina, and Alexey S. Kondrashov. “Two Linked Loci under Mutation-Selection Balance and Muller’s Ratchet.” <i>Journal of Theoretical Biology</i>. Elsevier, 2021. <a href=\"https://doi.org/10.1016/j.jtbi.2021.110729\">https://doi.org/10.1016/j.jtbi.2021.110729</a>."},"quality_controlled":"1","volume":524,"publication_identifier":{"issn":["0022-5193"]},"article_number":"110729","acknowledgement":"This work was supported by the Russian Science Foundation grant N 16-14-10173."}]