--- OA_place: publisher OA_type: hybrid _id: '22959' abstract: - lang: eng text: 'With this status report, we aim to provide a timely snapshot of the protein engineering field as a broad and rapidly advancing discipline that integrates computational, molecular biology, structure-guided, evolutionary, and synthetic approaches to create new and improved proteins with tailored structures and useful functions. The report is organized into eight thematic areas spanning core methodologies and major application domains, including enzymes, therapeutics, detection, synthetic biology, and materials. Contributions from experts across these areas highlight both the historical foundations and recent advances in their respective fields, with particular emphasis on the growing influence of machine learning and artificial intelligence-based methods. Emerging from this broad overview is a central message: protein engineering appears to be entering a golden age, defined by a rapidly accelerating pace of progress, even as significant challenges in design, screening, and real-world application remain. Looking ahead, the continued integration of computational and experimental strategies is poised to further accelerate the impact of protein engineering across an expanding range of economically and societally important sectors, from therapeutics and molecular imaging to diagnostics, plastic recycling, and industrial chemistry.' acknowledgement: "Research in the lab of H.A. is supported by the National Institutes of Health (R01EB033172, R01EB035430, and R01AG077773).\r\n\r\nResearch in the lab of F.H.A. is supported by the US Army Research Office cooperative agreement for the Institute for Collaborative Biotechnologies (W911NF-19-2-0026) and the US Department of Energy, Office of Science, Office of Basic Energy Sciences (DE-SC0021141). This report was prepared as an account of work sponsored by an agency of the US Government. Neither the US Government nor any agency thereof, nor any of their employees, makes any warranty, express or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed, or represents that its use would not infringe privately owned rights. Reference herein to any specific commercial product, process, or service by trade name, trademark, manufacturer, or otherwise does not necessarily constitute or imply its endorsement, recommendation, or favoring by the US Government or any agency thereof. The views and opinions of authors expressed herein do not necessarily state or reflect those of the US Government or any agency thereof.\r\n\r\nResearch in the lab of D.B. has been supported by National Institutes of Health (NIH) (R35-GM158123-01 and R01-GM068462).\r\n\r\nResearch in the lab of H.B. is supported by grants from the Bill & Melinda Gates Foundation and Oxford Nanopore Technologies.\r\n\r\nResearch in the lab of R.E.C. is supported by grants from the Japan Society for the Promotion of Science (JSPS) (23K26794, 24H00489, and 24H02267), Japan Science and Technology Agency (JST) (JPMJCR25T3), the Mitsubishi Foundation, and the NIH (U01NS123658).\r\n\r\nResearch in the lab of P.C. is supported by grants from the Vidyasirimedhi Institute of Science and Technology (VISTEC), NSRF via the Program Management Unit for Human Resources & Institutional Development (PMU-B) Research and Innovation grant number B05F640089, and KasikornBank Public Company Limited.\r\n\r\nResearch in the lab of R.A.C. is supported by grants from the Natural Sciences and Engineering Research Council of Canada (RGPIN-2021-03484, RGPAS-2021-00017, and ALLRP-597074-24), the Human Frontier Science Program (RGP0004/2022) and the Canada Foundation for Innovation (26503 and 42695). B.J.S. was supported by an NSERC Canada Graduate Research Scholarship.\r\n\r\nResearch in the lab of V.G.H.E. is supported by grants from the European Research Council, ERC (grant number 856446, CUBE), the Novo Nordisk Foundation (Emerging Investigator grant to A.V.; grant number 0061165) and the Research Council of Norway (grant numbers 309558, Centre for Industrial Biotechnology, SFI-IB, and 257622, Bio4Fuels).\r\n\r\nThis project in the lab of R.F. was supported by Robert A. Welch Foundation (AT-0051-20221212), and the Cancer Prevention and Research Institute of Texas (grant RR230018).\r\n\r\nResearch in the lab of M.S.F. is supported by ETH Zurich and the Swiss National Science Foundation (SNSF) under grant number CR00I5-235927.\r\n\r\nThis project in the lab of J.J.G is supported by the NIH (R35 GM141881) and a National Science Foundation (NSF) Graduate Research Fellowship Program to M.C.\r\n\r\nRelated research in the lab of B.H. is supported by the German Research Foundation (DFG) Project Number 391977956—SFB 1357 Microplastics, subproject C03 and by the European Union’s Horizon 2020 research and innovation programme under grant agreement No 951375 (ERC Synergy—ArtMotor).\r\n\r\nRelated work in the lab of S.C.L.K. is supported by the NSF under Grant No. 2414074. S.C.L.K. is the Georgia Research Alliance—Vasser Wooley Chair of Molecular Design at Georgia Tech.\r\n\r\nResearch in the lab of N.K. is supported by grants from the JSPS (24H02261).\r\n\r\nThis project in the lab of B.K. was supported by the NIH (R35 GM131923).\r\n\r\nResearch in the lab of R.E.K. on bispecific antibodies is supported by a grant from the Baden-Württemberg Stiftung and various industry collaborations. Past research was funded by the Deutsche Krebshilfe, the BMBF, and the Deutsche Forschungsgemeinschaft.\r\n\r\nResearch in the lab of R.D.L. (Protein Engineering and Structural Genomics group) is supported by grants from Brazilian National Research Council—CNPq (303833/2022-0, 307370/2025-9), the Oswaldo Cruz Fondation—Fiocruz (VPPIS-004-FIO-22, IAM-005-FIO-22, VPPCB-002-FIO25), and the Brazilian National Supercomputing Center—LNCC.\r\n\r\nChemical protein synthesis research in the lab of L.L. is supported by NSFC (22137005, 22227810, T2488301) and New Cornerstone Science Foundation.\r\n\r\nResearch in the lab of M.M.M. is supported by a Wellcome Trust/Royal Society Sir Henry Dale Fellowship (202250/Z/16/Z); the Biotechnology and Biological Sciences Research Council (BB/W015730/1) and a UKRI Postdoc Guarantee Fellowship (Horizon Europe Guarantee via EPSRC EP/Z000823/1 to L.F.G).\r\n\r\nResearch in the lab of F.Z. is partially supported by the Natural Science Foundation of Shaanxi Province (2025SF-YBXM-421).\r\n\r\nResearch in the lab of J.K.N. is supported by the NIH (R35GM155044), Biohub, San Francisco, the Pew Charitable Trusts, The Vallee Foundation, The Shurl and Kay Curci Foundation, the Bakar Fellows Program, and a Sloan Research Fellowship. I.J.O. acknowledges support from a Gilliam Fellowship from the Howard Hughes Medical Institute.\r\n\r\nResearch in the lab of J.N.P. is supported by the Natural Science and Engineering Research Council of Canada (RGPIN-N-2018-04686) and the Canada Research Chair in Engineering of Applied Proteins (CRC-2020-00171). D.J.F. is supported by a fellowship from the Fonds de recherche du Québec.\r\n\r\nResearch in the lab of A.P. has been supported predominantly by grants from the SNSF, the European Union, the European Research Council, as well as by pre- and postdoctoral fellowships to the co-workers.\r\n\r\nResearch in the lab of Y.Q. is supported by a Horizon Europe Guarantee ERC Starting Grant (EP/Z000351/1) and a Biotechnology and Biological Sciences Research Council Research Grant (BB/W00349X/1).\r\n\r\nJ.C.R. acknowledges partial support from the SNSF Postdoc.Mobility (P500PN_214290). The author thanks Chenghao Liu and Jason Yang for fruitful discussions.\r\n\r\nResearch in the lab of S.S. is supported by a NWO-VIDI grant from the Netherlands Organization for Scientific Research (NWO, VI.Vidi.213.025) and the European Research Council, ERC (grant agreement number 101075934, ReCNNSTRCT).\r\n\r\nResearch in the lab of J.B.S. is supported by a Helmsley Charitable Trust grant and a Swim Across America grant.\r\n\r\nThis project in the lab of C.L.T. was supported by a grant from the National Institute of General Medical Sciences of the NIH (R35GM136367).\r\n\r\nResearch on ncAAs in the lab of J.A.V. is supported by a grant from the National Institute of General Medical Sciences of the NIH (R35GM133471) and a grant from the NSF (2339201). The content is solely the responsibility of the author and does not necessarily represent the official views of the NIH or the NSF.\r\n\r\nResearch in the lab of A.M.W is supported by an NIH Director’s New Innovator Award (DP2GM149548), a David and Lucille Packard Fellowship for Science and Engineering (2021-73007), an Ono Pharma Foundation Breakthrough Science Initiative Award (149802896), and the University of Wisconsin—Madison Department of Biochemistry.\r\n\r\nProjects in the lab of A.H-W.Y. are supported by NIH/NIBIB R00EB031913, UCSC startup/Innovation Catalyst Grant, and Chan Zuckerberg Initiative (2024-337820).\r\n\r\nResearch in the lab of J.Zhang is supported by NIH grants R35 CA197622, R01 DK073368, R01 DE030497, R01 HL162302, R01 CA262815, and RF1 MH126707.\r\n\r\nResearch in the lab of H. Z. is supported by the DOE Center for Advanced Bioenergy and Bioproducts Innovation (U.S. Department of Energy, Office of Science, Biological and Environmental Research Program under Award Number DE-SC0018420), National Science Foundation (NSF) (DBI-2400058, OISE-2435374, IIS-2435755, and CHE-2505932), and National Institutes of Health (NIH) (AI144967). Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the DOE, NSF or NIH.\r\n\r\nThe authors are grateful to the anonymous peer reviewers and to Anna Devor for inspiration and guidance for preparing this manuscript." article_number: gzag020 article_processing_charge: No article_type: review author: - first_name: Hui-wang full_name: Ai, Hui-wang last_name: Ai - first_name: Frances H full_name: Arnold, Frances H last_name: Arnold - first_name: Doug full_name: Barrick, Doug last_name: Barrick - first_name: Hagan full_name: Bayley, Hagan last_name: Bayley - first_name: Alfie-Louise R full_name: Brownless, Alfie-Louise R last_name: Brownless - first_name: Robert E full_name: Campbell, Robert E last_name: Campbell - first_name: Roger full_name: Castells-Graells, Roger last_name: Castells-Graells - first_name: Pimchai full_name: Chaiyen, Pimchai last_name: Chaiyen - first_name: Roberto A full_name: Chica, Roberto A last_name: Chica - first_name: Lauren O full_name: Chisholm, Lauren O last_name: Chisholm - first_name: Daniel full_name: Christ, Daniel last_name: Christ - first_name: Guo-Chao full_name: Chu, Guo-Chao last_name: Chu - first_name: Michael full_name: Chungyoun, Michael last_name: Chungyoun - first_name: Vincent G H full_name: Eijsink, Vincent G H last_name: Eijsink - first_name: Michael B full_name: Elowitz, Michael B last_name: Elowitz - first_name: Douglas J full_name: Fansher, Douglas J last_name: Fansher - first_name: Rudi full_name: Fasan, Rudi last_name: Fasan - first_name: Gabriel full_name: Foley, Gabriel last_name: Foley - first_name: Michelle S full_name: Frei, Michelle S last_name: Frei - first_name: Andreas full_name: Gagsteiger, Andreas last_name: Gagsteiger - first_name: Ruiyan full_name: Gao, Ruiyan last_name: Gao - first_name: Elizabeth M J full_name: Gillam, Elizabeth M J last_name: Gillam - first_name: Jeffrey J full_name: Gray, Jeffrey J last_name: Gray - first_name: Luis F full_name: Guerra, Luis F last_name: Guerra - first_name: Birte full_name: Höcker, Birte last_name: Höcker - first_name: Zhiyang full_name: Jin, Zhiyang last_name: Jin - first_name: Shina Caroline Lynn full_name: Kamerlin, Shina Caroline Lynn last_name: Kamerlin - first_name: Nobuyasu full_name: Koga, Nobuyasu last_name: Koga - first_name: Roland E full_name: Kontermann, Roland E last_name: Kontermann - first_name: Brian full_name: Kuhlman, Brian last_name: Kuhlman - first_name: Olivia A full_name: Langlois, Olivia A last_name: Langlois - first_name: Dongyang full_name: Li, Dongyang last_name: Li - first_name: Roberto D full_name: Lins, Roberto D last_name: Lins - first_name: Chang C full_name: Liu, Chang C last_name: Liu - first_name: Lei full_name: Liu, Lei last_name: Liu - first_name: Diego full_name: López Barreiro, Diego last_name: López Barreiro - first_name: Peilong full_name: Lu, Peilong last_name: Lu - first_name: Sohum full_name: Mehta, Sohum last_name: Mehta - first_name: Ikumi full_name: Miyazaki, Ikumi last_name: Miyazaki - first_name: Manuel M full_name: Müller, Manuel M last_name: Müller - first_name: Serge full_name: Muyldermans, Serge last_name: Muyldermans - first_name: Naoto full_name: Nemoto, Naoto last_name: Nemoto - first_name: Jeff full_name: Nivala, Jeff last_name: Nivala - first_name: James K full_name: Nuñez, James K last_name: Nuñez - first_name: Izaiah J full_name: Ornelas, Izaiah J last_name: Ornelas - first_name: Joelle N full_name: Pelletier, Joelle N last_name: Pelletier - first_name: Andreas full_name: Plückthun, Andreas last_name: Plückthun - first_name: Owen T full_name: Porth, Owen T last_name: Porth - first_name: Kridsadakorn full_name: Prakinee, Kridsadakorn last_name: Prakinee - first_name: Yujia full_name: Qing, Yujia last_name: Qing - first_name: Julia full_name: Reisenbauer, Julia id: 51d862e9-36ee-11f0-86d3-8534c85a5496 last_name: Reisenbauer - first_name: Sandy full_name: Schmidt, Sandy last_name: Schmidt - first_name: Oliver full_name: Seifert, Oliver last_name: Seifert - first_name: Mikhail G full_name: Shapiro, Mikhail G last_name: Shapiro - first_name: Rachna full_name: Sharma, Rachna last_name: Sharma - first_name: Nilmani full_name: Singh, Nilmani last_name: Singh - first_name: Benjamin J full_name: Smith, Benjamin J last_name: Smith - first_name: Jamie B full_name: Spangler, Jamie B last_name: Spangler - first_name: Rie full_name: Tatsumi-Koga, Rie last_name: Tatsumi-Koga - first_name: Takuya full_name: Terai, Takuya last_name: Terai - first_name: Henrik full_name: Terholsen, Henrik last_name: Terholsen - first_name: Mattias full_name: Tolhurst, Mattias last_name: Tolhurst - first_name: Katherine W full_name: Tripp, Katherine W last_name: Tripp - first_name: Vanessa Tanja full_name: Trossmann, Vanessa Tanja last_name: Trossmann - first_name: Chandra L full_name: Tucker, Chandra L last_name: Tucker - first_name: Onur full_name: Turak, Onur last_name: Turak - first_name: James A full_name: Van Deventer, James A last_name: Van Deventer - first_name: Anikó full_name: Várnai, Anikó last_name: Várnai - first_name: Isabelle F T full_name: Viana, Isabelle F T last_name: Viana - first_name: Amy M full_name: Weeks, Amy M last_name: Weeks - first_name: K Dane full_name: Wittrup, K Dane last_name: Wittrup - first_name: Kingsley L-J full_name: Wong, Kingsley L-J last_name: Wong - first_name: Chenggang full_name: Xi, Chenggang last_name: Xi - first_name: Todd O full_name: Yeates, Todd O last_name: Yeates - first_name: Andy Hsien-Wei full_name: Yeh, Andy Hsien-Wei last_name: Yeh - first_name: Jin full_name: Zhang, Jin last_name: Zhang - first_name: Tiger S full_name: Zhang, Tiger S last_name: Zhang - first_name: Huimin full_name: Zhao, Huimin last_name: Zhao - first_name: Fang full_name: Zheng, Fang last_name: Zheng - first_name: Jingyi full_name: Zhu, Jingyi last_name: Zhu - first_name: Sacha full_name: Zinn, Sacha last_name: Zinn citation: ama: 'Ai H, Arnold FH, Barrick D, et al. Protein engineering: Status report. Protein Engineering, Design and Selection. 2026;39. doi:10.1093/protein/gzag020' apa: 'Ai, H., Arnold, F. H., Barrick, D., Bayley, H., Brownless, A.-L. R., Campbell, R. E., … Zinn, S. (2026). Protein engineering: Status report. Protein Engineering, Design and Selection. Oxford University Press. https://doi.org/10.1093/protein/gzag020' chicago: 'Ai, Hui-wang, Frances H Arnold, Doug Barrick, Hagan Bayley, Alfie-Louise R Brownless, Robert E Campbell, Roger Castells-Graells, et al. “Protein Engineering: Status Report.” Protein Engineering, Design and Selection. Oxford University Press, 2026. https://doi.org/10.1093/protein/gzag020.' ieee: 'H. Ai et al., “Protein engineering: Status report,” Protein Engineering, Design and Selection, vol. 39. Oxford University Press, 2026.' ista: 'Ai H, Arnold FH, Barrick D, Bayley H, Brownless A-LR, Campbell RE, Castells-Graells R, Chaiyen P, Chica RA, Chisholm LO, Christ D, Chu G-C, Chungyoun M, Eijsink VGH, Elowitz MB, Fansher DJ, Fasan R, Foley G, Frei MS, Gagsteiger A, Gao R, Gillam EMJ, Gray JJ, Guerra LF, Höcker B, Jin Z, Kamerlin SCL, Koga N, Kontermann RE, Kuhlman B, Langlois OA, Li D, Lins RD, Liu CC, Liu L, López Barreiro D, Lu P, Mehta S, Miyazaki I, Müller MM, Muyldermans S, Nemoto N, Nivala J, Nuñez JK, Ornelas IJ, Pelletier JN, Plückthun A, Porth OT, Prakinee K, Qing Y, Reisenbauer J, Schmidt S, Seifert O, Shapiro MG, Sharma R, Singh N, Smith BJ, Spangler JB, Tatsumi-Koga R, Terai T, Terholsen H, Tolhurst M, Tripp KW, Trossmann VT, Tucker CL, Turak O, Van Deventer JA, Várnai A, Viana IFT, Weeks AM, Wittrup KD, Wong KL-J, Xi C, Yeates TO, Yeh AH-W, Zhang J, Zhang TS, Zhao H, Zheng F, Zhu J, Zinn S. 2026. Protein engineering: Status report. Protein Engineering, Design and Selection. 39, gzag020.' mla: 'Ai, Hui-wang, et al. “Protein Engineering: Status Report.” Protein Engineering, Design and Selection, vol. 39, gzag020, Oxford University Press, 2026, doi:10.1093/protein/gzag020.' short: H. Ai, F.H. Arnold, D. Barrick, H. Bayley, A.-L.R. Brownless, R.E. Campbell, R. Castells-Graells, P. Chaiyen, R.A. Chica, L.O. Chisholm, D. Christ, G.-C. Chu, M. Chungyoun, V.G.H. Eijsink, M.B. Elowitz, D.J. Fansher, R. Fasan, G. Foley, M.S. Frei, A. Gagsteiger, R. Gao, E.M.J. Gillam, J.J. Gray, L.F. Guerra, B. Höcker, Z. Jin, S.C.L. Kamerlin, N. Koga, R.E. Kontermann, B. Kuhlman, O.A. Langlois, D. Li, R.D. Lins, C.C. Liu, L. Liu, D. López Barreiro, P. Lu, S. Mehta, I. Miyazaki, M.M. Müller, S. Muyldermans, N. Nemoto, J. Nivala, J.K. Nuñez, I.J. Ornelas, J.N. Pelletier, A. Plückthun, O.T. Porth, K. Prakinee, Y. Qing, J. Reisenbauer, S. Schmidt, O. Seifert, M.G. Shapiro, R. Sharma, N. Singh, B.J. Smith, J.B. Spangler, R. Tatsumi-Koga, T. Terai, H. Terholsen, M. Tolhurst, K.W. Tripp, V.T. Trossmann, C.L. Tucker, O. Turak, J.A. Van Deventer, A. Várnai, I.F.T. Viana, A.M. Weeks, K.D. Wittrup, K.L.-J. Wong, C. Xi, T.O. Yeates, A.H.-W. Yeh, J. Zhang, T.S. Zhang, H. Zhao, F. Zheng, J. Zhu, S. Zinn, Protein Engineering, Design and Selection 39 (2026). das_tickbox: '1' dataavailabilitystatement: No new data were generated or analysed in support of this research. date_created: 2026-09-17T11:06:36Z date_published: 2026-07-17T00:00:00Z date_updated: 2026-10-01T09:29:15Z day: '17' ddc: - '570' department: - _id: JuRe doi: 10.1093/protein/gzag020 external_id: pmid: - '42466865' file: - access_level: open_access checksum: 4015ecfe11b3b0cac757d5bdd10d3c1d content_type: application/pdf creator: dernst date_created: 2026-10-01T09:24:22Z date_updated: 2026-10-01T09:24:22Z file_id: '23019' file_name: 2026_ProteinEngineeringDesignSelection_Ai.pdf file_size: 12603911 relation: main_file success: 1 file_date_updated: 2026-10-01T09:24:22Z fulldoi: https://doi.org/10.1093/protein/gzag020 has_accepted_license: '1' intvolume: ' 39' language: - iso: eng month: '07' oa: 1 oa_version: Published Version pmid: 1 publication: Protein Engineering, Design and Selection publication_identifier: eissn: - 1741-0134 issn: - 1741-0126 publication_status: published publisher: Oxford University Press quality_controlled: '1' researchdata_availability: no scopus_import: '1' status: public supplementarymaterial: no title: 'Protein engineering: Status report' tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 39 year: '2026' ... --- OA_place: publisher OA_type: hybrid _id: '20755' abstract: - lang: eng text: We report the development of a continuous flow approach to nitrogen atom insertion. The setup is modular, enabling the rapid optimization of reaction conditions for a wide range of substrates. The milder reaction conditions led to an improved substrate scope and functional group tolerance compared to batch conditions. The reactions can also be safely scaled up to preparative scale. article_processing_charge: Yes (in subscription journal) article_type: original author: - first_name: Sooyeon full_name: Moon, Sooyeon last_name: Moon - first_name: Julia full_name: Reisenbauer, Julia id: 51d862e9-36ee-11f0-86d3-8534c85a5496 last_name: Reisenbauer - first_name: Ann-Sophie K. full_name: Paschke, Ann-Sophie K. last_name: Paschke - first_name: Alessandro full_name: Scotto, Alessandro last_name: Scotto - first_name: Luca full_name: Terraneo, Luca last_name: Terraneo - first_name: Niklas full_name: Brenner, Niklas last_name: Brenner - first_name: Quentin full_name: Lefebvre, Quentin last_name: Lefebvre - first_name: Thomas C. full_name: Fessard, Thomas C. last_name: Fessard - first_name: Bill full_name: Morandi, Bill last_name: Morandi citation: ama: Moon S, Reisenbauer J, Paschke A-SK, et al. Efficient optimization and synthesis of diverse azaarenes via nitrogen atom insertion under continuous flow conditions. Chemical Communications. 2025;61(87):16993-16996. doi:10.1039/d5cc03194j apa: Moon, S., Reisenbauer, J., Paschke, A.-S. K., Scotto, A., Terraneo, L., Brenner, N., … Morandi, B. (2025). Efficient optimization and synthesis of diverse azaarenes via nitrogen atom insertion under continuous flow conditions. Chemical Communications. Royal Society of Chemistry. https://doi.org/10.1039/d5cc03194j chicago: Moon, Sooyeon, Julia Reisenbauer, Ann-Sophie K. Paschke, Alessandro Scotto, Luca Terraneo, Niklas Brenner, Quentin Lefebvre, Thomas C. Fessard, and Bill Morandi. “Efficient Optimization and Synthesis of Diverse Azaarenes via Nitrogen Atom Insertion under Continuous Flow Conditions.” Chemical Communications. Royal Society of Chemistry, 2025. https://doi.org/10.1039/d5cc03194j. ieee: S. Moon et al., “Efficient optimization and synthesis of diverse azaarenes via nitrogen atom insertion under continuous flow conditions,” Chemical Communications, vol. 61, no. 87. Royal Society of Chemistry, pp. 16993–16996, 2025. ista: Moon S, Reisenbauer J, Paschke A-SK, Scotto A, Terraneo L, Brenner N, Lefebvre Q, Fessard TC, Morandi B. 2025. Efficient optimization and synthesis of diverse azaarenes via nitrogen atom insertion under continuous flow conditions. Chemical Communications. 61(87), 16993–16996. mla: Moon, Sooyeon, et al. “Efficient Optimization and Synthesis of Diverse Azaarenes via Nitrogen Atom Insertion under Continuous Flow Conditions.” Chemical Communications, vol. 61, no. 87, Royal Society of Chemistry, 2025, pp. 16993–96, doi:10.1039/d5cc03194j. short: S. Moon, J. Reisenbauer, A.-S.K. Paschke, A. Scotto, L. Terraneo, N. Brenner, Q. Lefebvre, T.C. Fessard, B. Morandi, Chemical Communications 61 (2025) 16993–16996. date_created: 2025-12-09T14:22:09Z date_published: 2025-10-06T00:00:00Z date_updated: 2026-03-16T08:31:23Z day: '06' ddc: - '540' doi: 10.1039/d5cc03194j extern: '1' fulldoi: https://doi.org/10.1039/d5cc03194j has_accepted_license: '1' intvolume: ' 61' issue: '87' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.1039/D5CC03194J month: '10' oa: 1 oa_version: Published Version page: 16993-16996 publication: Chemical Communications publication_identifier: eissn: - 1364-548X issn: - 1359-7345 publication_status: published publisher: Royal Society of Chemistry quality_controlled: '1' scopus_import: '1' status: public title: Efficient optimization and synthesis of diverse azaarenes via nitrogen atom insertion under continuous flow conditions tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 61 year: '2025' ... --- OA_type: closed access _id: '20767' abstract: - lang: eng text: Chemistry education at the graduate level and beyond faces the formidable challenge of a boundless and constantly expanding frontier of knowledge on many fronts. While modern learners have an increasingly broad range of resources available at their disposal (including open access text-based references, online videos, training problems, and other digital learning materials), there are comparatively fewer such materials aimed at the highest levels of study. With the goal of producing widely accessible graduate-level learning content, we created a community-based approach to online course design that is easily digestible to meet the expectations of modern learners. Herein, we report the development of an open access Advanced Organic Chemistry video-based online course and several other specialized minicourses using the Synthesis Workshop YouTube channel. article_processing_charge: No article_type: original author: - first_name: Matthew A. full_name: Horwitz, Matthew A. last_name: Horwitz - first_name: Reem full_name: Al-Ahmad, Reem last_name: Al-Ahmad - first_name: Xingfeng full_name: Bai, Xingfeng last_name: Bai - first_name: Matteo full_name: Balletti, Matteo last_name: Balletti - first_name: Peter full_name: Bellotti, Peter last_name: Bellotti - first_name: Yael full_name: Ben-Tal, Yael last_name: Ben-Tal - first_name: Mark W. full_name: Campbell, Mark W. last_name: Campbell - first_name: Kathleen full_name: Cheasty, Kathleen last_name: Cheasty - first_name: Steven W. M. full_name: Crossley, Steven W. M. last_name: Crossley - first_name: Craig S. full_name: Day, Craig S. last_name: Day - first_name: Patrick J. full_name: Deneny, Patrick J. last_name: Deneny - first_name: Katherine C. full_name: Forbes, Katherine C. last_name: Forbes - first_name: Emma S. full_name: Gogarnoiu, Emma S. last_name: Gogarnoiu - first_name: Phillip S. full_name: Grant, Phillip S. last_name: Grant - first_name: Riya full_name: Halder, Riya last_name: Halder - first_name: Georgia R. full_name: Harris, Georgia R. last_name: Harris - first_name: Pol full_name: Hernández-Lladó, Pol last_name: Hernández-Lladó - first_name: Morgan full_name: Jouanneau, Morgan last_name: Jouanneau - first_name: Vera full_name: Jost, Vera last_name: Jost - first_name: Dennis A. full_name: Kutateladze, Dennis A. last_name: Kutateladze - first_name: Gabriele full_name: Laudadio, Gabriele last_name: Laudadio - first_name: Chun full_name: Liu, Chun last_name: Liu - first_name: Aidan P. full_name: Looby, Aidan P. last_name: Looby - first_name: Aitor full_name: Maestro, Aitor last_name: Maestro - first_name: Terry full_name: McCallum, Terry last_name: McCallum - first_name: Maximilian D. full_name: Palkowitz, Maximilian D. last_name: Palkowitz - first_name: Joshua M. full_name: Paolillo, Joshua M. last_name: Paolillo - first_name: Matthew W. D. full_name: Perry, Matthew W. D. last_name: Perry - first_name: Julia full_name: Reisenbauer, Julia id: 51d862e9-36ee-11f0-86d3-8534c85a5496 last_name: Reisenbauer - first_name: Cesar full_name: Reyes, Cesar last_name: Reyes - first_name: Hayden A. full_name: Sharma, Hayden A. last_name: Sharma - first_name: Fu Kit full_name: Sheong, Fu Kit last_name: Sheong - first_name: Benjamin full_name: Thoma, Benjamin last_name: Thoma - first_name: Andrew V. full_name: Tran, Andrew V. last_name: Tran - first_name: Duc N. full_name: Tran, Duc N. last_name: Tran - first_name: Francisco José full_name: Aguilar Troyano, Francisco José last_name: Aguilar Troyano - first_name: Thomas full_name: Verheyen, Thomas last_name: Verheyen - first_name: Mark P. full_name: Walsh, Mark P. last_name: Walsh - first_name: Alicia full_name: Wagner, Alicia last_name: Wagner - first_name: Emily R. full_name: Wearing, Emily R. last_name: Wearing - first_name: Georg full_name: Wuitschik, Georg last_name: Wuitschik citation: ama: 'Horwitz MA, Al-Ahmad R, Bai X, et al. Reimagining advanced chemistry education: A community-based approach to course design for modern learners. Journal of Chemical Education. 2025;102(9):3777-3783. doi:10.1021/acs.jchemed.5c00555' apa: 'Horwitz, M. A., Al-Ahmad, R., Bai, X., Balletti, M., Bellotti, P., Ben-Tal, Y., … Wuitschik, G. (2025). Reimagining advanced chemistry education: A community-based approach to course design for modern learners. Journal of Chemical Education. American Chemical Society. https://doi.org/10.1021/acs.jchemed.5c00555' chicago: 'Horwitz, Matthew A., Reem Al-Ahmad, Xingfeng Bai, Matteo Balletti, Peter Bellotti, Yael Ben-Tal, Mark W. Campbell, et al. “Reimagining Advanced Chemistry Education: A Community-Based Approach to Course Design for Modern Learners.” Journal of Chemical Education. American Chemical Society, 2025. https://doi.org/10.1021/acs.jchemed.5c00555.' ieee: 'M. A. Horwitz et al., “Reimagining advanced chemistry education: A community-based approach to course design for modern learners,” Journal of Chemical Education, vol. 102, no. 9. American Chemical Society, pp. 3777–3783, 2025.' ista: 'Horwitz MA, Al-Ahmad R, Bai X, Balletti M, Bellotti P, Ben-Tal Y, Campbell MW, Cheasty K, Crossley SWM, Day CS, Deneny PJ, Forbes KC, Gogarnoiu ES, Grant PS, Halder R, Harris GR, Hernández-Lladó P, Jouanneau M, Jost V, Kutateladze DA, Laudadio G, Liu C, Looby AP, Maestro A, McCallum T, Palkowitz MD, Paolillo JM, Perry MWD, Reisenbauer J, Reyes C, Sharma HA, Sheong FK, Thoma B, Tran AV, Tran DN, Aguilar Troyano FJ, Verheyen T, Walsh MP, Wagner A, Wearing ER, Wuitschik G. 2025. Reimagining advanced chemistry education: A community-based approach to course design for modern learners. Journal of Chemical Education. 102(9), 3777–3783.' mla: 'Horwitz, Matthew A., et al. “Reimagining Advanced Chemistry Education: A Community-Based Approach to Course Design for Modern Learners.” Journal of Chemical Education, vol. 102, no. 9, American Chemical Society, 2025, pp. 3777–83, doi:10.1021/acs.jchemed.5c00555.' short: M.A. Horwitz, R. Al-Ahmad, X. Bai, M. Balletti, P. Bellotti, Y. Ben-Tal, M.W. Campbell, K. Cheasty, S.W.M. Crossley, C.S. Day, P.J. Deneny, K.C. Forbes, E.S. Gogarnoiu, P.S. Grant, R. Halder, G.R. Harris, P. Hernández-Lladó, M. Jouanneau, V. Jost, D.A. Kutateladze, G. Laudadio, C. Liu, A.P. Looby, A. Maestro, T. McCallum, M.D. Palkowitz, J.M. Paolillo, M.W.D. Perry, J. Reisenbauer, C. Reyes, H.A. Sharma, F.K. Sheong, B. Thoma, A.V. Tran, D.N. Tran, F.J. Aguilar Troyano, T. Verheyen, M.P. Walsh, A. Wagner, E.R. Wearing, G. Wuitschik, Journal of Chemical Education 102 (2025) 3777–3783. date_created: 2025-12-09T14:27:11Z date_published: 2025-08-15T00:00:00Z date_updated: 2025-12-16T12:13:49Z day: '15' doi: 10.1021/acs.jchemed.5c00555 extern: '1' fulldoi: https://doi.org/10.1021/acs.jchemed.5c00555 intvolume: ' 102' issue: '9' language: - iso: eng month: '08' oa_version: None page: 3777-3783 publication: Journal of Chemical Education publication_identifier: eissn: - 1938-1328 issn: - 0021-9584 publication_status: published publisher: American Chemical Society quality_controlled: '1' scopus_import: '1' status: public title: 'Reimagining advanced chemistry education: A community-based approach to course design for modern learners' type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 102 year: '2025' ... --- OA_place: repository OA_type: green _id: '20756' abstract: - lang: eng text: Biocatalysis has the potential to address the need for more sustainable organic synthesis routes. Protein engineering can tune enzymes to perform in cascade reactions and for efficient synthesis of enantiomerically enriched compounds, using both natural and new-to-nature reaction pathways. This review highlights recent achievements in biocatalysis, especially the development of novel enzymatic syntheses to access versatile small molecule intermediates and complex biomolecules. Biocatalytic strategies for the degradation of persistent pollutants and approaches for biomass valorization are also discussed. The transition of chemical synthesis to a greener future will be accelerated by implementing enzymes and engineering them for high performance and new activities. article_number: '102536' article_processing_charge: No article_type: original author: - first_name: Julia full_name: Reisenbauer, Julia id: 51d862e9-36ee-11f0-86d3-8534c85a5496 last_name: Reisenbauer - first_name: Kathleen M. full_name: Sicinski, Kathleen M. last_name: Sicinski - first_name: Frances H. full_name: Arnold, Frances H. last_name: Arnold citation: ama: 'Reisenbauer J, Sicinski KM, Arnold FH. Catalyzing the future: Recent advances in chemical synthesis using enzymes. Current Opinion in Chemical Biology. 2024;83. doi:10.1016/j.cbpa.2024.102536' apa: 'Reisenbauer, J., Sicinski, K. M., & Arnold, F. H. (2024). Catalyzing the future: Recent advances in chemical synthesis using enzymes. Current Opinion in Chemical Biology. Elsevier. https://doi.org/10.1016/j.cbpa.2024.102536' chicago: 'Reisenbauer, Julia, Kathleen M. Sicinski, and Frances H. Arnold. “Catalyzing the Future: Recent Advances in Chemical Synthesis Using Enzymes.” Current Opinion in Chemical Biology. Elsevier, 2024. https://doi.org/10.1016/j.cbpa.2024.102536.' ieee: 'J. Reisenbauer, K. M. Sicinski, and F. H. Arnold, “Catalyzing the future: Recent advances in chemical synthesis using enzymes,” Current Opinion in Chemical Biology, vol. 83. Elsevier, 2024.' ista: 'Reisenbauer J, Sicinski KM, Arnold FH. 2024. Catalyzing the future: Recent advances in chemical synthesis using enzymes. Current Opinion in Chemical Biology. 83, 102536.' mla: 'Reisenbauer, Julia, et al. “Catalyzing the Future: Recent Advances in Chemical Synthesis Using Enzymes.” Current Opinion in Chemical Biology, vol. 83, 102536, Elsevier, 2024, doi:10.1016/j.cbpa.2024.102536.' short: J. Reisenbauer, K.M. Sicinski, F.H. Arnold, Current Opinion in Chemical Biology 83 (2024). date_created: 2025-12-09T14:22:40Z date_published: 2024-12-01T00:00:00Z date_updated: 2025-12-16T13:03:48Z day: '01' doi: 10.1016/j.cbpa.2024.102536 extern: '1' external_id: pmid: - '39369557' fulldoi: https://doi.org/10.1016/j.cbpa.2024.102536 intvolume: ' 83' language: - iso: eng main_file_link: - open_access: '1' url: https://europepmc.org/article/med/39369557#free-full-text month: '12' oa: 1 oa_version: Submitted Version pmid: 1 publication: Current Opinion in Chemical Biology publication_identifier: eissn: - 1879-0402 issn: - 1367-5931 publication_status: published publisher: Elsevier quality_controlled: '1' scopus_import: '1' status: public title: 'Catalyzing the future: Recent advances in chemical synthesis using enzymes' type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 83 year: '2024' ... --- OA_place: publisher OA_type: hybrid _id: '20757' abstract: - lang: eng text: We report the utilisation of an iodine(III) reagent to access α,β-unsaturated carbonyls from the corresponding silyl enol ethers and enol phosphates. The transformation can also be carried out in one pot, directly dehydrogenating carbonyls. article_processing_charge: No article_type: original author: - first_name: Bence B. full_name: Botlik, Bence B. last_name: Botlik - first_name: Patrick full_name: Finkelstein, Patrick last_name: Finkelstein - first_name: Ann-Sophie K. full_name: Paschke, Ann-Sophie K. last_name: Paschke - first_name: Julia full_name: Reisenbauer, Julia id: 51d862e9-36ee-11f0-86d3-8534c85a5496 last_name: Reisenbauer - first_name: Bill full_name: Morandi, Bill last_name: Morandi citation: ama: Botlik BB, Finkelstein P, Paschke A-SK, Reisenbauer J, Morandi B. Versatile dehydrogenation of carbonyls enabled by an iodine(III) reagent. Chemical Communications. 2024;60(69):9254-9257. doi:10.1039/d4cc02609h apa: Botlik, B. B., Finkelstein, P., Paschke, A.-S. K., Reisenbauer, J., & Morandi, B. (2024). Versatile dehydrogenation of carbonyls enabled by an iodine(III) reagent. Chemical Communications. Royal Society of Chemistry. https://doi.org/10.1039/d4cc02609h chicago: Botlik, Bence B., Patrick Finkelstein, Ann-Sophie K. Paschke, Julia Reisenbauer, and Bill Morandi. “Versatile Dehydrogenation of Carbonyls Enabled by an Iodine(III) Reagent.” Chemical Communications. Royal Society of Chemistry, 2024. https://doi.org/10.1039/d4cc02609h. ieee: B. B. Botlik, P. Finkelstein, A.-S. K. Paschke, J. Reisenbauer, and B. Morandi, “Versatile dehydrogenation of carbonyls enabled by an iodine(III) reagent,” Chemical Communications, vol. 60, no. 69. Royal Society of Chemistry, pp. 9254–9257, 2024. ista: Botlik BB, Finkelstein P, Paschke A-SK, Reisenbauer J, Morandi B. 2024. Versatile dehydrogenation of carbonyls enabled by an iodine(III) reagent. Chemical Communications. 60(69), 9254–9257. mla: Botlik, Bence B., et al. “Versatile Dehydrogenation of Carbonyls Enabled by an Iodine(III) Reagent.” Chemical Communications, vol. 60, no. 69, Royal Society of Chemistry, 2024, pp. 9254–57, doi:10.1039/d4cc02609h. short: B.B. Botlik, P. Finkelstein, A.-S.K. Paschke, J. Reisenbauer, B. Morandi, Chemical Communications 60 (2024) 9254–9257. date_created: 2025-12-09T14:23:00Z date_published: 2024-08-02T00:00:00Z date_updated: 2025-12-16T11:19:43Z day: '02' doi: 10.1039/d4cc02609h extern: '1' external_id: pmid: - '39118590' fulldoi: https://doi.org/10.1039/d4cc02609h has_accepted_license: '1' intvolume: ' 60' issue: '69' language: - iso: eng license: https://creativecommons.org/licenses/by-nc/3.0/ main_file_link: - open_access: '1' url: https://doi.org/10.1039/D4CC02609H month: '08' oa: 1 oa_version: Published Version page: 9254-9257 pmid: 1 publication: Chemical Communications publication_identifier: eissn: - 1364-548X issn: - 1359-7345 publication_status: published publisher: Royal Society of Chemistry quality_controlled: '1' scopus_import: '1' status: public title: Versatile dehydrogenation of carbonyls enabled by an iodine(III) reagent tmp: image: /images/cc_by_nc.png legal_code_url: https://creativecommons.org/licenses/by-nc/3.0/legalcode name: Creative Commons Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0) short: CC BY-NC (3.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 60 year: '2024' ... --- OA_type: closed access _id: '20759' abstract: - lang: eng text: Recent advances in single-atom insertion reactions have opened up new synthetic approaches for molecular diversification. Developing innovative strategies to directly transform biologically relevant molecules, without any prefunctionalization, is key to further expanding the scope and utility of such transformations. Herein, the direct access to quinazolines and pyrimidines from the corresponding unprotected 1H-indoles and 1H-pyrroles is reported, relying on the implementation of lithium bis(trimethylsilyl)amide (LiHMDS) as a novel nitrogen atom source in combination with commercially available hypervalent iodine reagents. Further application of this strategy in late-stage settings demonstrates its potential in lead structure diversification campaigns. article_processing_charge: No article_type: letter_note author: - first_name: Julia full_name: Reisenbauer, Julia id: 51d862e9-36ee-11f0-86d3-8534c85a5496 last_name: Reisenbauer - first_name: Ann-Sophie K. full_name: Paschke, Ann-Sophie K. last_name: Paschke - first_name: Jelena full_name: Krizic, Jelena last_name: Krizic - first_name: Bence B. full_name: Botlik, Bence B. last_name: Botlik - first_name: Patrick full_name: Finkelstein, Patrick last_name: Finkelstein - first_name: Bill full_name: Morandi, Bill last_name: Morandi citation: ama: Reisenbauer J, Paschke A-SK, Krizic J, Botlik BB, Finkelstein P, Morandi B. Direct access to quinazolines and pyrimidines from unprotected indoles and pyrroles through nitrogen atom insertion. Organic Letters. 2023;25(47):8419-8423. doi:10.1021/acs.orglett.3c03264 apa: Reisenbauer, J., Paschke, A.-S. K., Krizic, J., Botlik, B. B., Finkelstein, P., & Morandi, B. (2023). Direct access to quinazolines and pyrimidines from unprotected indoles and pyrroles through nitrogen atom insertion. Organic Letters. American Chemical Society. https://doi.org/10.1021/acs.orglett.3c03264 chicago: Reisenbauer, Julia, Ann-Sophie K. Paschke, Jelena Krizic, Bence B. Botlik, Patrick Finkelstein, and Bill Morandi. “Direct Access to Quinazolines and Pyrimidines from Unprotected Indoles and Pyrroles through Nitrogen Atom Insertion.” Organic Letters. American Chemical Society, 2023. https://doi.org/10.1021/acs.orglett.3c03264. ieee: J. Reisenbauer, A.-S. K. Paschke, J. Krizic, B. B. Botlik, P. Finkelstein, and B. Morandi, “Direct access to quinazolines and pyrimidines from unprotected indoles and pyrroles through nitrogen atom insertion,” Organic Letters, vol. 25, no. 47. American Chemical Society, pp. 8419–8423, 2023. ista: Reisenbauer J, Paschke A-SK, Krizic J, Botlik BB, Finkelstein P, Morandi B. 2023. Direct access to quinazolines and pyrimidines from unprotected indoles and pyrroles through nitrogen atom insertion. Organic Letters. 25(47), 8419–8423. mla: Reisenbauer, Julia, et al. “Direct Access to Quinazolines and Pyrimidines from Unprotected Indoles and Pyrroles through Nitrogen Atom Insertion.” Organic Letters, vol. 25, no. 47, American Chemical Society, 2023, pp. 8419–23, doi:10.1021/acs.orglett.3c03264. short: J. Reisenbauer, A.-S.K. Paschke, J. Krizic, B.B. Botlik, P. Finkelstein, B. Morandi, Organic Letters 25 (2023) 8419–8423. date_created: 2025-12-09T14:23:23Z date_published: 2023-11-20T00:00:00Z date_updated: 2025-12-16T11:07:40Z day: '20' doi: 10.1021/acs.orglett.3c03264 extern: '1' external_id: pmid: - '37983173' fulldoi: https://doi.org/10.1021/acs.orglett.3c03264 intvolume: ' 25' issue: '47' language: - iso: eng month: '11' oa_version: None page: 8419-8423 pmid: 1 publication: Organic Letters publication_identifier: eissn: - 1523-7052 issn: - 1523-7060 publication_status: published publisher: American Chemical Society quality_controlled: '1' scopus_import: '1' status: public title: Direct access to quinazolines and pyrimidines from unprotected indoles and pyrroles through nitrogen atom insertion type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 25 year: '2023' ... --- OA_place: publisher OA_type: hybrid PlanS_conform: '1' _id: '20760' abstract: - lang: eng text: The implementation of HCN-free transfer hydrocyanation reactions on laboratory scales has recently been achieved by using HCN donor reagents under nickel- and Lewis acid co-catalysis. More recently, malononitrile-based HCN donor reagents were shown to undergo the C(sp3)–CN bond activation by the nickel catalyst in the absence of Lewis acids. However, there is a lack of detailed mechanistic understanding of the challenging C(sp3)–CN bond cleavage step. In this work, in-depth kinetic and computational studies using alkynes as substrates were used to elucidate the overall reaction mechanism of this transfer hydrocyanation, with a particular focus on the activation of the C(sp3)–CN bond to generate the active H–Ni–CN transfer hydrocyanation catalyst. Comparisons of experimentally and computationally derived 13C kinetic isotope effect data support a direct oxidative addition mechanism of the nickel catalyst into the C(sp3)–CN bond facilitated by the coordination of the second nitrile group to the nickel catalyst. article_processing_charge: Yes (in subscription journal) article_type: original author: - first_name: Julia full_name: Reisenbauer, Julia id: 51d862e9-36ee-11f0-86d3-8534c85a5496 last_name: Reisenbauer - first_name: Patrick full_name: Finkelstein, Patrick last_name: Finkelstein - first_name: Marc-Olivier full_name: Ebert, Marc-Olivier last_name: Ebert - first_name: Bill full_name: Morandi, Bill last_name: Morandi citation: ama: Reisenbauer J, Finkelstein P, Ebert M-O, Morandi B. Mechanistic investigation of the nickel-catalyzed transfer hydrocyanation of alkynes. ACS Catalysis. 2023;13(17):11548-11555. doi:10.1021/acscatal.3c02977 apa: Reisenbauer, J., Finkelstein, P., Ebert, M.-O., & Morandi, B. (2023). Mechanistic investigation of the nickel-catalyzed transfer hydrocyanation of alkynes. ACS Catalysis. American Chemical Society. https://doi.org/10.1021/acscatal.3c02977 chicago: Reisenbauer, Julia, Patrick Finkelstein, Marc-Olivier Ebert, and Bill Morandi. “Mechanistic Investigation of the Nickel-Catalyzed Transfer Hydrocyanation of Alkynes.” ACS Catalysis. American Chemical Society, 2023. https://doi.org/10.1021/acscatal.3c02977. ieee: J. Reisenbauer, P. Finkelstein, M.-O. Ebert, and B. Morandi, “Mechanistic investigation of the nickel-catalyzed transfer hydrocyanation of alkynes,” ACS Catalysis, vol. 13, no. 17. American Chemical Society, pp. 11548–11555, 2023. ista: Reisenbauer J, Finkelstein P, Ebert M-O, Morandi B. 2023. Mechanistic investigation of the nickel-catalyzed transfer hydrocyanation of alkynes. ACS Catalysis. 13(17), 11548–11555. mla: Reisenbauer, Julia, et al. “Mechanistic Investigation of the Nickel-Catalyzed Transfer Hydrocyanation of Alkynes.” ACS Catalysis, vol. 13, no. 17, American Chemical Society, 2023, pp. 11548–55, doi:10.1021/acscatal.3c02977. short: J. Reisenbauer, P. Finkelstein, M.-O. Ebert, B. Morandi, ACS Catalysis 13 (2023) 11548–11555. date_created: 2025-12-09T14:23:42Z date_published: 2023-08-16T00:00:00Z date_updated: 2025-12-16T11:11:14Z day: '16' doi: 10.1021/acscatal.3c02977 extern: '1' external_id: pmid: - '37671177' fulldoi: https://doi.org/10.1021/acscatal.3c02977 has_accepted_license: '1' intvolume: ' 13' issue: '17' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.1021/acscatal.3c02977 month: '08' oa: 1 oa_version: Published Version page: 11548-11555 pmid: 1 publication: ACS Catalysis publication_identifier: eissn: - 2155-5435 publication_status: published publisher: American Chemical Society quality_controlled: '1' scopus_import: '1' status: public title: Mechanistic investigation of the nickel-catalyzed transfer hydrocyanation of alkynes tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 13 year: '2023' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: gold _id: '20761' abstract: - lang: eng text: We report a convenient protocol for a nitrogen atom insertion into indenes to afford isoquinolines. The reaction uses a combination of commercially available phenyliodine(III) diacetate (PIDA) and ammonium carbamate as the nitrogen source to furnish a wide range of isoquinolines. Various substitution patterns and commonly used functional groups are well tolerated. The operational simplicity renders this protocol broadly applicable and has been successfully extended towards the direct interconversion of cyclopentadienes into the corresponding pyridines. Furthermore, this strategy enables the facile synthesis of 15N labelled isoquinolines, using 15NH4Cl as a commercial 15N source. article_processing_charge: Yes article_type: original author: - first_name: Patrick full_name: Finkelstein, Patrick last_name: Finkelstein - first_name: Julia full_name: Reisenbauer, Julia id: 51d862e9-36ee-11f0-86d3-8534c85a5496 last_name: Reisenbauer - first_name: Bence B. full_name: Botlik, Bence B. last_name: Botlik - first_name: Ori full_name: Green, Ori last_name: Green - first_name: Andri full_name: Florin, Andri last_name: Florin - first_name: Bill full_name: Morandi, Bill last_name: Morandi citation: ama: Finkelstein P, Reisenbauer J, Botlik BB, Green O, Florin A, Morandi B. Nitrogen atom insertion into indenes to access isoquinolines. Chemical Science. 2023;14(11):2954-2959. doi:10.1039/d2sc06952k apa: Finkelstein, P., Reisenbauer, J., Botlik, B. B., Green, O., Florin, A., & Morandi, B. (2023). Nitrogen atom insertion into indenes to access isoquinolines. Chemical Science. Royal Society of Chemistry. https://doi.org/10.1039/d2sc06952k chicago: Finkelstein, Patrick, Julia Reisenbauer, Bence B. Botlik, Ori Green, Andri Florin, and Bill Morandi. “Nitrogen Atom Insertion into Indenes to Access Isoquinolines.” Chemical Science. Royal Society of Chemistry, 2023. https://doi.org/10.1039/d2sc06952k. ieee: P. Finkelstein, J. Reisenbauer, B. B. Botlik, O. Green, A. Florin, and B. Morandi, “Nitrogen atom insertion into indenes to access isoquinolines,” Chemical Science, vol. 14, no. 11. Royal Society of Chemistry, pp. 2954–2959, 2023. ista: Finkelstein P, Reisenbauer J, Botlik BB, Green O, Florin A, Morandi B. 2023. Nitrogen atom insertion into indenes to access isoquinolines. Chemical Science. 14(11), 2954–2959. mla: Finkelstein, Patrick, et al. “Nitrogen Atom Insertion into Indenes to Access Isoquinolines.” Chemical Science, vol. 14, no. 11, Royal Society of Chemistry, 2023, pp. 2954–59, doi:10.1039/d2sc06952k. short: P. Finkelstein, J. Reisenbauer, B.B. Botlik, O. Green, A. Florin, B. Morandi, Chemical Science 14 (2023) 2954–2959. date_created: 2025-12-09T14:23:59Z date_published: 2023-02-23T00:00:00Z date_updated: 2025-12-16T11:18:13Z day: '23' ddc: - '540' doi: 10.1039/d2sc06952k extern: '1' external_id: pmid: - '36937579' fulldoi: https://doi.org/10.1039/d2sc06952k has_accepted_license: '1' intvolume: ' 14' issue: '11' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.1039/D2SC06952K month: '02' oa: 1 oa_version: Published Version page: 2954-2959 pmid: 1 publication: Chemical Science publication_identifier: eissn: - 2041-6539 issn: - 2041-6520 publication_status: published publisher: Royal Society of Chemistry quality_controlled: '1' scopus_import: '1' status: public title: Nitrogen atom insertion into indenes to access isoquinolines tmp: image: /images/cc_by_nc.png legal_code_url: https://creativecommons.org/licenses/by-nc/3.0/legalcode name: Creative Commons Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0) short: CC BY-NC (3.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 14 year: '2023' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: gold _id: '20762' abstract: - lang: eng text: "A metal-free deaminative coupling of non-prefunctionalised benzylamines and arylboronic acids is reported. In this operationally simple reaction, a primary amine in benzylamine is converted into a good leaving group in situ using inexpensive and commercially available isoamyl nitrite as a nitrosating reagent. Lewis-acidic arylboronic acids are shown to replace mineral acids such as HCl or HBF4 that are conventionally used in the preparation of aryl diazonium salts. This unlocked the formation of the corresponding diarylmethanes by forging a new C–C bond in good yields.\r\n\r\n" article_processing_charge: Yes article_type: original author: - first_name: Giedre full_name: Sirvinskaite, Giedre last_name: Sirvinskaite - first_name: Julia full_name: Reisenbauer, Julia id: 51d862e9-36ee-11f0-86d3-8534c85a5496 last_name: Reisenbauer - first_name: Bill full_name: Morandi, Bill last_name: Morandi citation: ama: Sirvinskaite G, Reisenbauer J, Morandi B. Deaminative coupling of benzylamines and arylboronic acids. Chemical Science. 2023;14(7):1709-1714. doi:10.1039/d2sc06055h apa: Sirvinskaite, G., Reisenbauer, J., & Morandi, B. (2023). Deaminative coupling of benzylamines and arylboronic acids. Chemical Science. Royal Society of Chemistry. https://doi.org/10.1039/d2sc06055h chicago: Sirvinskaite, Giedre, Julia Reisenbauer, and Bill Morandi. “Deaminative Coupling of Benzylamines and Arylboronic Acids.” Chemical Science. Royal Society of Chemistry, 2023. https://doi.org/10.1039/d2sc06055h. ieee: G. Sirvinskaite, J. Reisenbauer, and B. Morandi, “Deaminative coupling of benzylamines and arylboronic acids,” Chemical Science, vol. 14, no. 7. Royal Society of Chemistry, pp. 1709–1714, 2023. ista: Sirvinskaite G, Reisenbauer J, Morandi B. 2023. Deaminative coupling of benzylamines and arylboronic acids. Chemical Science. 14(7), 1709–1714. mla: Sirvinskaite, Giedre, et al. “Deaminative Coupling of Benzylamines and Arylboronic Acids.” Chemical Science, vol. 14, no. 7, Royal Society of Chemistry, 2023, pp. 1709–14, doi:10.1039/d2sc06055h. short: G. Sirvinskaite, J. Reisenbauer, B. Morandi, Chemical Science 14 (2023) 1709–1714. date_created: 2025-12-09T14:24:17Z date_published: 2023-01-13T00:00:00Z date_updated: 2025-12-16T11:17:41Z day: '13' doi: 10.1039/d2sc06055h extern: '1' external_id: pmid: - '36819866' fulldoi: https://doi.org/10.1039/d2sc06055h has_accepted_license: '1' intvolume: ' 14' issue: '7' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.1039/D2SC06055H month: '01' oa: 1 oa_version: Published Version page: 1709-1714 pmid: 1 publication: Chemical Science publication_identifier: eissn: - 2041-6539 issn: - 2041-6520 publication_status: published publisher: Royal Society of Chemistry quality_controlled: '1' scopus_import: '1' status: public title: Deaminative coupling of benzylamines and arylboronic acids tmp: image: /images/cc_by_nc.png legal_code_url: https://creativecommons.org/licenses/by-nc/3.0/legalcode name: Creative Commons Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0) short: CC BY-NC (3.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 14 year: '2023' ... --- OA_place: repository OA_type: green _id: '20763' abstract: - lang: eng text: Compared with peripheral late-stage transformations mainly focusing on carbon–hydrogen functionalizations, reliable strategies to directly edit the core skeleton of pharmaceutical lead compounds still remain scarce despite the recent flurry of activity in this area. Herein, we report the skeletal editing of indoles through nitrogen atom insertion, accessing the corresponding quinazoline or quinoxaline bioisosteres by trapping of an electrophilic nitrene species generated from ammonium carbamate and hypervalent iodine. This reactivity relies on the strategic use of a silyl group as a labile protecting group that can facilitate subsequent product release. The utility of this highly functional group-compatible methodology in the context of late-stage skeletal editing of several commercial drugs is demonstrated. article_processing_charge: No article_type: original author: - first_name: Julia full_name: Reisenbauer, Julia id: 51d862e9-36ee-11f0-86d3-8534c85a5496 last_name: Reisenbauer - first_name: Ori full_name: Green, Ori last_name: Green - first_name: Allegra full_name: Franchino, Allegra last_name: Franchino - first_name: Patrick full_name: Finkelstein, Patrick last_name: Finkelstein - first_name: Bill full_name: Morandi, Bill last_name: Morandi citation: ama: Reisenbauer J, Green O, Franchino A, Finkelstein P, Morandi B. Late-stage diversification of indole skeletons through nitrogen atom insertion. Science. 2022;377(6610):1104-1109. doi:10.1126/science.add1383 apa: Reisenbauer, J., Green, O., Franchino, A., Finkelstein, P., & Morandi, B. (2022). Late-stage diversification of indole skeletons through nitrogen atom insertion. Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.add1383 chicago: Reisenbauer, Julia, Ori Green, Allegra Franchino, Patrick Finkelstein, and Bill Morandi. “Late-Stage Diversification of Indole Skeletons through Nitrogen Atom Insertion.” Science. American Association for the Advancement of Science, 2022. https://doi.org/10.1126/science.add1383. ieee: J. Reisenbauer, O. Green, A. Franchino, P. Finkelstein, and B. Morandi, “Late-stage diversification of indole skeletons through nitrogen atom insertion,” Science, vol. 377, no. 6610. American Association for the Advancement of Science, pp. 1104–1109, 2022. ista: Reisenbauer J, Green O, Franchino A, Finkelstein P, Morandi B. 2022. Late-stage diversification of indole skeletons through nitrogen atom insertion. Science. 377(6610), 1104–1109. mla: Reisenbauer, Julia, et al. “Late-Stage Diversification of Indole Skeletons through Nitrogen Atom Insertion.” Science, vol. 377, no. 6610, American Association for the Advancement of Science, 2022, pp. 1104–09, doi:10.1126/science.add1383. short: J. Reisenbauer, O. Green, A. Franchino, P. Finkelstein, B. Morandi, Science 377 (2022) 1104–1109. date_created: 2025-12-09T14:24:37Z date_published: 2022-09-01T00:00:00Z date_updated: 2025-12-16T11:59:34Z day: '01' doi: 10.1126/science.add1383 extern: '1' external_id: pmid: - '36048958' fulldoi: https://doi.org/10.1126/science.add1383 intvolume: ' 377' issue: '6610' language: - iso: eng main_file_link: - open_access: '1' url: 10.26434/chemrxiv-2022-jvfxw month: '09' oa: 1 oa_version: Preprint page: 1104-1109 pmid: 1 publication: Science publication_identifier: eissn: - 1095-9203 issn: - 0036-8075 publication_status: published publisher: American Association for the Advancement of Science quality_controlled: '1' scopus_import: '1' status: public title: Late-stage diversification of indole skeletons through nitrogen atom insertion type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 377 year: '2022' ... --- OA_place: repository OA_type: green _id: '20764' abstract: - lang: eng text: Hydrocyanation reactions enable access to synthetically valuable nitriles from readily available alkene precursors. However, hydrocyanation reactions using hydrogen cyanide (HCN) or similarly toxic reagents on laboratory scale can be particularly challenging due to their hazardous nature. In addition, such processes typically require air- and temperature-sensitive Ni(0) precatalysts, further reducing the operational simplicity of this transformation. Herein, we report a HCN-free transfer hydrocyanation of alkenes and alkynes that employs commercially available aliphatic nitriles as sacrificial HCN donors in combination with a catalytic amount of air-stable and inexpensive NiCl2 as a precatalyst and a cocatalytic Lewis acid. The scalability and robustness of the catalytic process were demonstrated by the hydrocyanation of α-methylstyrene on a 100 mmol scale (11.4 g of product obtained) using 1 mol % of the Ni catalyst. In addition, the feasibility of the dehydrocyanation protocol using the air-stable Ni(II) precatalyst and norbornadiene as a sacrificial acceptor was showcased by the selective conversion of an aliphatic nitrile into the corresponding alkene. article_processing_charge: No article_type: original author: - first_name: Julia full_name: Reisenbauer, Julia id: 51d862e9-36ee-11f0-86d3-8534c85a5496 last_name: Reisenbauer - first_name: Benjamin N. full_name: Bhawal, Benjamin N. last_name: Bhawal - first_name: Nicola full_name: Jelmini, Nicola last_name: Jelmini - first_name: Bill full_name: Morandi, Bill last_name: Morandi citation: ama: Reisenbauer J, Bhawal BN, Jelmini N, Morandi B. Development of an operationally simple, scalable, and HCN-free transfer hydrocyanation protocol using an air-stable nickel precatalyst. Organic Process Research & Development. 2022;26(4):1165-1173. doi:10.1021/acs.oprd.1c00442 apa: Reisenbauer, J., Bhawal, B. N., Jelmini, N., & Morandi, B. (2022). Development of an operationally simple, scalable, and HCN-free transfer hydrocyanation protocol using an air-stable nickel precatalyst. Organic Process Research & Development. American Chemical Society. https://doi.org/10.1021/acs.oprd.1c00442 chicago: Reisenbauer, Julia, Benjamin N. Bhawal, Nicola Jelmini, and Bill Morandi. “Development of an Operationally Simple, Scalable, and HCN-Free Transfer Hydrocyanation Protocol Using an Air-Stable Nickel Precatalyst.” Organic Process Research & Development. American Chemical Society, 2022. https://doi.org/10.1021/acs.oprd.1c00442. ieee: J. Reisenbauer, B. N. Bhawal, N. Jelmini, and B. Morandi, “Development of an operationally simple, scalable, and HCN-free transfer hydrocyanation protocol using an air-stable nickel precatalyst,” Organic Process Research & Development, vol. 26, no. 4. American Chemical Society, pp. 1165–1173, 2022. ista: Reisenbauer J, Bhawal BN, Jelmini N, Morandi B. 2022. Development of an operationally simple, scalable, and HCN-free transfer hydrocyanation protocol using an air-stable nickel precatalyst. Organic Process Research & Development. 26(4), 1165–1173. mla: Reisenbauer, Julia, et al. “Development of an Operationally Simple, Scalable, and HCN-Free Transfer Hydrocyanation Protocol Using an Air-Stable Nickel Precatalyst.” Organic Process Research & Development, vol. 26, no. 4, American Chemical Society, 2022, pp. 1165–73, doi:10.1021/acs.oprd.1c00442. short: J. Reisenbauer, B.N. Bhawal, N. Jelmini, B. Morandi, Organic Process Research & Development 26 (2022) 1165–1173. date_created: 2025-12-09T14:24:58Z date_published: 2022-02-15T00:00:00Z date_updated: 2025-12-16T12:02:59Z day: '15' doi: 10.1021/acs.oprd.1c00442 extern: '1' fulldoi: https://doi.org/10.1021/acs.oprd.1c00442 intvolume: ' 26' issue: '4' language: - iso: eng main_file_link: - open_access: '1' url: https://www.research-collection.ethz.ch/entities/publication/4ed5123f-eb11-4a4d-b06c-f50edcec38b8 month: '02' oa: 1 oa_version: Submitted Version page: 1165-1173 publication: Organic Process Research & Development publication_identifier: eissn: - 1520-586X issn: - 1083-6160 publication_status: published publisher: American Chemical Society quality_controlled: '1' scopus_import: '1' status: public title: Development of an operationally simple, scalable, and HCN-free transfer hydrocyanation protocol using an air-stable nickel precatalyst type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 26 year: '2022' ... --- OA_place: publisher OA_type: hybrid _id: '20765' abstract: - lang: eng text:

A cascade Suzuki–Miyaura cross-coupling between two non-symmetrical coupling partners gave rise to 9,10-dihydrophenanthrenes with full site-selectivity. The choice of base was critical to facilitate the challenging coupling of the secondary boronate group.

article_processing_charge: No article_type: original author: - first_name: Suzanne full_name: Willems, Suzanne last_name: Willems - first_name: Georgios full_name: Toupalas, Georgios last_name: Toupalas - first_name: Julia full_name: Reisenbauer, Julia id: 51d862e9-36ee-11f0-86d3-8534c85a5496 last_name: Reisenbauer - first_name: Bill full_name: Morandi, Bill last_name: Morandi citation: ama: Willems S, Toupalas G, Reisenbauer J, Morandi B. A site-selective and stereospecific cascade Suzuki–Miyaura annulation of alkyl 1,2-bisboronic esters and 2,2′-dihalo 1,1′-biaryls. Chemical Communications. 2021;57(32):3909-3912. doi:10.1039/d1cc00648g apa: Willems, S., Toupalas, G., Reisenbauer, J., & Morandi, B. (2021). A site-selective and stereospecific cascade Suzuki–Miyaura annulation of alkyl 1,2-bisboronic esters and 2,2′-dihalo 1,1′-biaryls. Chemical Communications. Royal Society of Chemistry. https://doi.org/10.1039/d1cc00648g chicago: Willems, Suzanne, Georgios Toupalas, Julia Reisenbauer, and Bill Morandi. “A Site-Selective and Stereospecific Cascade Suzuki–Miyaura Annulation of Alkyl 1,2-Bisboronic Esters and 2,2′-Dihalo 1,1′-Biaryls.” Chemical Communications. Royal Society of Chemistry, 2021. https://doi.org/10.1039/d1cc00648g. ieee: S. Willems, G. Toupalas, J. Reisenbauer, and B. Morandi, “A site-selective and stereospecific cascade Suzuki–Miyaura annulation of alkyl 1,2-bisboronic esters and 2,2′-dihalo 1,1′-biaryls,” Chemical Communications, vol. 57, no. 32. Royal Society of Chemistry, pp. 3909–3912, 2021. ista: Willems S, Toupalas G, Reisenbauer J, Morandi B. 2021. A site-selective and stereospecific cascade Suzuki–Miyaura annulation of alkyl 1,2-bisboronic esters and 2,2′-dihalo 1,1′-biaryls. Chemical Communications. 57(32), 3909–3912. mla: Willems, Suzanne, et al. “A Site-Selective and Stereospecific Cascade Suzuki–Miyaura Annulation of Alkyl 1,2-Bisboronic Esters and 2,2′-Dihalo 1,1′-Biaryls.” Chemical Communications, vol. 57, no. 32, Royal Society of Chemistry, 2021, pp. 3909–12, doi:10.1039/d1cc00648g. short: S. Willems, G. Toupalas, J. Reisenbauer, B. Morandi, Chemical Communications 57 (2021) 3909–3912. date_created: 2025-12-09T14:25:17Z date_published: 2021-03-15T00:00:00Z date_updated: 2025-12-16T12:06:53Z day: '15' ddc: - '540' doi: 10.1039/d1cc00648g extern: '1' external_id: pmid: - '33871510' fulldoi: https://doi.org/10.1039/d1cc00648g has_accepted_license: '1' intvolume: ' 57' issue: '32' language: - iso: eng license: https://creativecommons.org/licenses/by/3.0/ main_file_link: - open_access: '1' url: "DOI\thttps://doi.org/10.1039/D1CC00648G" month: '03' oa: 1 oa_version: Published Version page: 3909-3912 pmid: 1 publication: Chemical Communications publication_identifier: eissn: - 1364-548X issn: - 1359-7345 publication_status: published publisher: Royal Society of Chemistry quality_controlled: '1' scopus_import: '1' status: public title: A site-selective and stereospecific cascade Suzuki–Miyaura annulation of alkyl 1,2-bisboronic esters and 2,2′-dihalo 1,1′-biaryls tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/3.0/legalcode name: Creative Commons Attribution 3.0 Unported (CC BY 3.0) short: CC BY (3.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 57 year: '2021' ... --- OA_place: repository OA_type: green _id: '20766' abstract: - lang: eng text: Reversible catalytic reactions operate under thermodynamic control, and thus, establishing a selective catalytic system poses a considerable challenge. Herein, we report a reversible transfer hydrocyanation protocol that exhibits high selectivity for the thermodynamically less favorable branched isomer. Selectivity is achieved by exploiting the lower barrier for C–CN oxidative addition and reductive elimination at benzylic positions in the absence of a cocatalytic Lewis acid. Through the design of a novel type of HCN donor, a practical, branched-selective, HCN-free transfer hydrocyanation was realized. The synthetically useful resolution of a mixture of branched and linear nitrile isomers was also demonstrated to underline the value of reversible and selective transfer reactions. In a broader context, this work demonstrates that high kinetic selectivity can be achieved in reversible transfer reactions, thus opening new horizons for their synthetic applications. article_processing_charge: No article_type: original author: - first_name: Benjamin N. full_name: Bhawal, Benjamin N. last_name: Bhawal - first_name: Julia full_name: Reisenbauer, Julia id: 51d862e9-36ee-11f0-86d3-8534c85a5496 last_name: Reisenbauer - first_name: Christian full_name: Ehinger, Christian last_name: Ehinger - first_name: Bill full_name: Morandi, Bill last_name: Morandi citation: ama: 'Bhawal BN, Reisenbauer J, Ehinger C, Morandi B. Overcoming selectivity issues in reversible catalysis: A transfer hydrocyanation exhibiting high kinetic control. Journal of the American Chemical Society. 2020;142(25):10914-10920. doi:10.1021/jacs.0c03184' apa: 'Bhawal, B. N., Reisenbauer, J., Ehinger, C., & Morandi, B. (2020). Overcoming selectivity issues in reversible catalysis: A transfer hydrocyanation exhibiting high kinetic control. Journal of the American Chemical Society. American Chemical Society. https://doi.org/10.1021/jacs.0c03184' chicago: 'Bhawal, Benjamin N., Julia Reisenbauer, Christian Ehinger, and Bill Morandi. “Overcoming Selectivity Issues in Reversible Catalysis: A Transfer Hydrocyanation Exhibiting High Kinetic Control.” Journal of the American Chemical Society. American Chemical Society, 2020. https://doi.org/10.1021/jacs.0c03184.' ieee: 'B. N. Bhawal, J. Reisenbauer, C. Ehinger, and B. Morandi, “Overcoming selectivity issues in reversible catalysis: A transfer hydrocyanation exhibiting high kinetic control,” Journal of the American Chemical Society, vol. 142, no. 25. American Chemical Society, pp. 10914–10920, 2020.' ista: 'Bhawal BN, Reisenbauer J, Ehinger C, Morandi B. 2020. Overcoming selectivity issues in reversible catalysis: A transfer hydrocyanation exhibiting high kinetic control. Journal of the American Chemical Society. 142(25), 10914–10920.' mla: 'Bhawal, Benjamin N., et al. “Overcoming Selectivity Issues in Reversible Catalysis: A Transfer Hydrocyanation Exhibiting High Kinetic Control.” Journal of the American Chemical Society, vol. 142, no. 25, American Chemical Society, 2020, pp. 10914–20, doi:10.1021/jacs.0c03184.' short: B.N. Bhawal, J. Reisenbauer, C. Ehinger, B. Morandi, Journal of the American Chemical Society 142 (2020) 10914–10920. date_created: 2025-12-09T14:25:37Z date_published: 2020-06-01T00:00:00Z date_updated: 2025-12-16T12:10:08Z day: '01' doi: 10.1021/jacs.0c03184 extern: '1' external_id: pmid: - '32478515' fulldoi: https://doi.org/10.1021/jacs.0c03184 intvolume: ' 142' issue: '25' language: - iso: eng main_file_link: - open_access: '1' url: 10.26434/chemrxiv.11931633.v1 month: '06' oa: 1 oa_version: Preprint page: 10914-10920 pmid: 1 publication: Journal of the American Chemical Society publication_identifier: eissn: - 1520-5126 issn: - 0002-7863 publication_status: published publisher: American Chemical Society quality_controlled: '1' scopus_import: '1' status: public title: 'Overcoming selectivity issues in reversible catalysis: A transfer hydrocyanation exhibiting high kinetic control' type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 142 year: '2020' ...