@article{21948,
  abstract     = {The cerebral cortex comprises diverse neuron and glial cell types generated by radial glial progenitors (RGPs) during development. Although RGPs broadly differentiate according to temporally and spatially regulated molecular logics, the lineage hierarchies linking individual progenitors to defined cell (sub)types are not well understood. Clone-resolved transcriptomics, combining molecular barcoding and single-cell RNA sequencing, allow high-resolution lineage tracing at the single-clone/cell level across different species and models. In this mini-review, we synthesize recent advances in this field, uncovering unexpected lineage relationships in the developing brain, with a particular focus on the cerebral cortex. We further highlight new insights into species-specific differences in the developmental programs generating cell-type diversity, linking changes in clonal architecture to lineage diversification during cortical evolution.},
  author       = {Varela Martínez, Irene and Pipicelli, Fabrizia and Hippenmeyer, Simon},
  issn         = {1879-0380},
  journal      = {Current Opinion in Genetics & Development},
  publisher    = {Elsevier},
  title        = {{Tracing cell lineages in the developing brain: Insights from mosaic analysis and clone-resolved transcriptomics}},
  doi          = {10.1016/j.gde.2026.102487},
  volume       = {99},
  year         = {2026},
}

@article{19718,
  abstract     = {The cerebral cortex is arguably the most complex organ in humans. The cortical architecture is characterized by a remarkable diversity of neuronal and glial cell types that make up its neuronal circuits. Following a precise temporally ordered program, radial glia progenitor (RGP) cells generate all cortical excitatory projection neurons and glial cell-types. Cortical excitatory projection neurons are produced either directly or via intermediate progenitors, through indirect neurogenesis. How the extensive cortical cell-type diversity is generated during cortex development remains, however, a fundamental open question. How do RGPs quantitatively and qualitatively generate all the neocortical neurons? How does direct and indirect neurogenesis contribute to the establishment of neuronal and lineage heterogeneity? Whether RGPs represent a homogeneous and/or multipotent progenitor population, or if RGPs consist of heterogeneous groups is currently also not known. In this review, we will summarize the latest findings that contributed to a deeper insight into the above key questions.},
  author       = {Pipicelli, Fabrizia and Villalba Requena, Ana and Hippenmeyer, Simon},
  issn         = {0959-4388},
  journal      = {Current Opinion in Neurobiology},
  publisher    = {Elsevier},
  title        = {{How radial glia progenitor lineages generate cell-type diversity in the developing cerebral cortex}},
  doi          = {10.1016/j.conb.2025.103046},
  volume       = {93},
  year         = {2025},
}