[{"department":[{"_id":"LifeSc"}],"citation":{"chicago":"Wu, Jiaojiao, Valentina Corvaglia, Tulika Chakrabortty, Pradeep K Mandal, and Ivan Huc. “Tailoring the Major Groove of DNA Mimic Foldamers.” <i>Chemical Science</i>. Royal Society of Chemistry, n.d. <a href=\"https://doi.org/10.1039/d6sc00798h\">https://doi.org/10.1039/d6sc00798h</a>.","ista":"Wu J, Corvaglia V, Chakrabortty T, Mandal PK, Huc I. Tailoring the major groove of DNA mimic foldamers. Chemical Science.","ama":"Wu J, Corvaglia V, Chakrabortty T, Mandal PK, Huc I. Tailoring the major groove of DNA mimic foldamers. <i>Chemical Science</i>. doi:<a href=\"https://doi.org/10.1039/d6sc00798h\">10.1039/d6sc00798h</a>","ieee":"J. Wu, V. Corvaglia, T. Chakrabortty, P. K. Mandal, and I. Huc, “Tailoring the major groove of DNA mimic foldamers,” <i>Chemical Science</i>. Royal Society of Chemistry.","mla":"Wu, Jiaojiao, et al. “Tailoring the Major Groove of DNA Mimic Foldamers.” <i>Chemical Science</i>, Royal Society of Chemistry, doi:<a href=\"https://doi.org/10.1039/d6sc00798h\">10.1039/d6sc00798h</a>.","apa":"Wu, J., Corvaglia, V., Chakrabortty, T., Mandal, P. K., &#38; Huc, I. (n.d.). Tailoring the major groove of DNA mimic foldamers. <i>Chemical Science</i>. Royal Society of Chemistry. <a href=\"https://doi.org/10.1039/d6sc00798h\">https://doi.org/10.1039/d6sc00798h</a>","short":"J. Wu, V. Corvaglia, T. Chakrabortty, P.K. Mandal, I. Huc, Chemical Science (n.d.)."},"year":"2026","publisher":"Royal Society of Chemistry","OA_place":"publisher","doi":"10.1039/d6sc00798h","date_updated":"2026-07-13T11:24:29Z","scopus_import":"1","publication_identifier":{"eissn":["2041-6539"],"issn":["2041-6520"]},"das_tickbox":"1","license":"https://creativecommons.org/licenses/by/4.0/","ddc":["540"],"acknowledgement":"We acknowledge financial support from the European Research Council (ERC) under the European Union's Horizon Europe Framework Programme (grant agreement no. ERC-2021-ADG-320892) and from the China Scholarship Council (CSC, predoctoral fellowship to J. W.). We thank L. Allmendinger for assistance with NMR measurements, P. Mayer for his assistance in solving the crystal structures of 1 and 1d, L. Bodero for assistance with automated solid-phase synthesis, M. Rogovoi for providing monomer precursors, and M. Loos for the purification and analysis of compounds 15a–19a. We thank M. Soler-Lopez (ID23-1, ESRF, Grenoble) and I. Bento (EMBL P13, Petra III, DESY, Hamburg) for assistance during data collection at the synchrotron beamlines.","fulldoi":"https://doi.org/10.1039/d6sc00798h","author":[{"last_name":"Wu","first_name":"Jiaojiao","full_name":"Wu, Jiaojiao"},{"last_name":"Corvaglia","first_name":"Valentina","full_name":"Corvaglia, Valentina"},{"first_name":"Tulika","full_name":"Chakrabortty, Tulika","last_name":"Chakrabortty"},{"last_name":"Mandal","id":"6a3def15-d4b4-11ef-9fa9-a24c1f545ec3","first_name":"Pradeep K","orcid":"0000-0001-5996-956X","full_name":"Mandal, Pradeep K"},{"first_name":"Ivan","full_name":"Huc, Ivan","last_name":"Huc"}],"publication":"Chemical Science","title":"Tailoring the major groove of DNA mimic foldamers","language":[{"iso":"eng"}],"article_type":"original","article_processing_charge":"Yes","has_accepted_license":"1","abstract":[{"text":"Single-stranded, helically folded aromatic oligoamides bearing anionic phosphonate side chains have been shown to bind to some DNA-binding proteins better than DNA itself. However, these DNA mimic foldamers have until now mainly consisted of a single repeat motif, like a poly(dA:dT) DNA duplex, and contained limited sequence information. Here, we introduce new monomers designed to display different chemical functionalities in the major groove of the DNA mimics. Four new Fmoc-protected amino acid monomers have been synthesized and incorporated into oligomers. Sixteen foldamer sequences were prepared on solid phase. Their conformations in solution and in the solid state and their conformational dynamics were investigated using nuclear magnetic resonance, circular dichroism, molecular modeling, and X-ray crystallography. The results show that three of the four new monomers behaved as designed and that their introduction enhances the conformational dynamics of the DNA mimic foldamers. In a fourth case, conformational behavior proved to be more complex than expected. The modified sequences retained the ability to bind to the bacterial histone-like protein HU. These results showcase design strategies to manipulate large molecular biomimetics in which not only side chains but also main chain components are varied. The new monomers pave the way to complex DNA mimic foldamer sequences targeting proteins that recognize sequence-selective DNA-binding proteins such as transcription factors or restriction enzymes.","lang":"eng"}],"publication_status":"inpress","supplementarymaterial":"yes","status":"public","date_published":"2026-06-09T00:00:00Z","oa_version":"Published Version","month":"06","researchdata_availability":"yes","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2026-07-13T09:41:36Z","OA_type":"gold","dataavailabilitystatement":"CCDC 2514117, 2514118, 2286782 and 2478322 (compound 1, compound 1d, oligomer 5, and oligomer 6, respectively) contain the supplementary crystallographic data for this paper.54a–d \r\n\r\nThe supporting data have been provided as part of the supplementary information (SI). Supplementary information: SI figures, detailed experimental protocols, crystallographic studies, and characterisation of new compounds. See DOI: https://doi.org/10.1039/d6sc00798h.","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"DOAJ_listed":"1","type":"journal_article","_id":"22289","day":"09","quality_controlled":"1"},{"article_type":"original","language":[{"iso":"eng"}],"date_published":"2026-08-19T00:00:00Z","has_accepted_license":"1","abstract":[{"text":"Single stranded helically folded aromatic oligoamides bearing anionic phosphonate side chains have been shown to bind to some DNA-binding proteins better than DNA itself. However, these DNA mimic foldamers have until now mainly consisted of a single repeat motif, like a poly(dA:dT) DNA duplex, and contained limited sequence information. Here, we introduce new monomers designed to display different chemical functionalities in the major groove of the DNA mimics. Four new Fmoc-protected amino acid monomers have been synthesized and incorporated into oligomers. Sixteen foldamer sequences were prepared on solid phase. Their conformation in solution and in the solid state and their conformational dynamics were investigated using NMR, circular dichroism, molecular modeling, and X-ray crystallography. The results show that three of four new monomers behaved as designed, and that their introduction enhances the conformational dynamics of the DNA mimic foldamers. In a fourth case, conformational behavior proved to be more complex than expected. The modified sequences retained an ability to bind to bacterial histone-like protein HU. These results showcase design strategies to manipulate large molecular biomimetics where not only side chains but also main chain components are varied. The new monomers pave the way to complex DNA mimic foldamer sequences targeting proteins that recognize sequence-selective DNA-binding proteins such as transcription factors or restriction enzymes.","lang":"eng"}],"status":"public","publication_status":"published","supplementarymaterial":"yes","article_processing_charge":"Yes","oa_version":"Published Version","date_created":"2026-06-16T08:04:15Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","researchdata_availability":"yes","intvolume":"        17","month":"08","dataavailabilitystatement":"CCDC 2514117, 2514118, 2286782 and 2478322 (compound 1, compound 1d, oligomer 5, and oligomer 6, respectively) contain the supplementary crystallographic data for this paper.54a–d \r\n\r\nThe supporting data have been provided as part of the supplementary information (SI). Supplementary information: SI figures, detailed experimental protocols, crystallographic studies, and characterisation of new compounds. See DOI: https://doi.org/10.1039/d6sc00798h.","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"OA_type":"gold","DOAJ_listed":"1","oa":1,"PlanS_conform":"1","quality_controlled":"1","day":"19","_id":"22012","type":"journal_article","volume":17,"publisher":"Royal Society of Chemistry","year":"2026","citation":{"short":"J. Wu, V. Corvaglia, T. Chakrabortty, P.K. Mandal, I. Huc, Chemical Science 17 (2026) 15479–15489.","apa":"Wu, J., Corvaglia, V., Chakrabortty, T., Mandal, P. K., &#38; Huc, I. (2026). Tailoring the major groove of DNA mimic foldamers. <i>Chemical Science</i>. Royal Society of Chemistry. <a href=\"https://doi.org/10.1039/d6sc00798h\">https://doi.org/10.1039/d6sc00798h</a>","mla":"Wu, Jiaojiao, et al. “Tailoring the Major Groove of DNA Mimic Foldamers.” <i>Chemical Science</i>, vol. 17, no. 32, Royal Society of Chemistry, 2026, pp. 15479–15489, doi:<a href=\"https://doi.org/10.1039/d6sc00798h\">10.1039/d6sc00798h</a>.","ieee":"J. Wu, V. Corvaglia, T. Chakrabortty, P. K. Mandal, and I. Huc, “Tailoring the major groove of DNA mimic foldamers,” <i>Chemical Science</i>, vol. 17, no. 32. Royal Society of Chemistry, pp. 15479–15489, 2026.","ama":"Wu J, Corvaglia V, Chakrabortty T, Mandal PK, Huc I. Tailoring the major groove of DNA mimic foldamers. <i>Chemical Science</i>. 2026;17(32):15479–15489. doi:<a href=\"https://doi.org/10.1039/d6sc00798h\">10.1039/d6sc00798h</a>","ista":"Wu J, Corvaglia V, Chakrabortty T, Mandal PK, Huc I. 2026. Tailoring the major groove of DNA mimic foldamers. Chemical Science. 17(32), 15479–15489.","chicago":"Wu, Jiaojiao, Valentina Corvaglia, Tulika Chakrabortty, Pradeep K Mandal, and Ivan Huc. “Tailoring the Major Groove of DNA Mimic Foldamers.” <i>Chemical Science</i>. Royal Society of Chemistry, 2026. <a href=\"https://doi.org/10.1039/d6sc00798h\">https://doi.org/10.1039/d6sc00798h</a>."},"department":[{"_id":"LifeSc"}],"OA_place":"publisher","scopus_import":"1","external_id":{"pmid":["42388815"]},"pmid":1,"date_updated":"2026-10-19T08:35:08Z","doi":"10.1039/d6sc00798h","das_tickbox":"1","publication_identifier":{"issn":["2041-6520"],"eissn":["2041-6539"]},"acknowledgement":"We acknowledge financial support from the European Research Council (ERC) under the European Union's Horizon Europe Framework Programme (grant agreement no. ERC-2021-ADG-320892) and from the China Scholarship Council (CSC, predoctoral fellowship to J. W.). We thank L. Allmendinger for assistance with NMR measurements, P. Mayer for his assistance in solving the crystal structures of 1 and 1d, L. Bodero for assistance with automated solid-phase synthesis, M. Rogovoi for providing monomer precursors, and M. Loos for the purification and analysis of compounds 15a–19a. We thank M. Soler-Lopez (ID23-1, ESRF, Grenoble) and I. Bento (EMBL P13, Petra III, DESY, Hamburg) for assistance during data collection at the synchrotron beamlines.","ddc":["540"],"issue":"32","file_date_updated":"2026-10-19T08:32:00Z","author":[{"first_name":"Jiaojiao","full_name":"Wu, Jiaojiao","last_name":"Wu"},{"first_name":"Valentina","full_name":"Corvaglia, Valentina","last_name":"Corvaglia"},{"last_name":"Chakrabortty","first_name":"Tulika","full_name":"Chakrabortty, Tulika"},{"id":"6a3def15-d4b4-11ef-9fa9-a24c1f545ec3","last_name":"Mandal","full_name":"Mandal, Pradeep K","first_name":"Pradeep K","orcid":"0000-0001-5996-956X"},{"last_name":"Huc","first_name":"Ivan","full_name":"Huc, Ivan"}],"publication":"Chemical Science","fulldoi":"https://doi.org/10.1039/d6sc00798h","file":[{"access_level":"open_access","success":1,"checksum":"fee032060eb71cba73afa8e301b9ee94","relation":"main_file","file_id":"23169","creator":"dernst","date_updated":"2026-10-19T08:32:00Z","content_type":"application/pdf","date_created":"2026-10-19T08:32:00Z","file_name":"2026_ChemicalScience_Wu.pdf","file_size":1361818}],"page":"15479–15489","title":"Tailoring the major groove of DNA mimic foldamers"},{"month":"07","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1002/anie.202505273"}],"intvolume":"        64","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2026-01-08T07:04:48Z","OA_type":"hybrid","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"oa":1,"type":"journal_article","_id":"20960","day":"28","quality_controlled":"1","PlanS_conform":"1","language":[{"iso":"eng"}],"article_type":"original","article_number":"e202505273","article_processing_charge":"Yes (in subscription journal)","has_accepted_license":"1","abstract":[{"text":"A linker unit was designed and synthesized that can serve both as a hairpin turn in a DNA duplex and anchor point for an aromatic helical foldamer mimicking the shape and surface properties of B‐DNA. Methods were developed to synthesize natural/non‐natural chimeric molecules combining foldamer and DNA segments. The ability of the linker to position the foldamer helix and the duplex DNA so that their rims and grooves are in register, despite their completely different chemical nature, was demonstrated using single crystal X‐ray diffraction, circular dichroism and molecular models. Bio‐layer interferometry confirmed that artificial hairpin DNA duplexes keep their ability to bind to DNA binding proteins. The chimeric molecules may pave the way to competitive inhibitors of protein‐DNA interactions involving sequence‐selective DNA‐binding proteins.","lang":"eng"}],"status":"public","publication_status":"published","date_published":"2025-07-28T00:00:00Z","extern":"1","oa_version":"Published Version","publication_identifier":{"eissn":["1521-3773"],"issn":["1433-7851"]},"issue":"31","ddc":["540"],"fulldoi":"https://doi.org/10.1002/anie.202505273","author":[{"last_name":"Loos","first_name":"Manuel","full_name":"Loos, Manuel"},{"full_name":"Xu, Felix","first_name":"Felix","last_name":"Xu"},{"first_name":"Pradeep K","orcid":"0000-0001-5996-956X","full_name":"Mandal, Pradeep K","last_name":"Mandal","id":"6a3def15-d4b4-11ef-9fa9-a24c1f545ec3"},{"last_name":"Chakrabortty","first_name":"Tulika","full_name":"Chakrabortty, Tulika"},{"last_name":"Douat","first_name":"Céline","full_name":"Douat, Céline"},{"last_name":"Konrad","full_name":"Konrad, David B.","first_name":"David B."},{"last_name":"Cabbar","first_name":"Melis","full_name":"Cabbar, Melis"},{"last_name":"Singer","full_name":"Singer, Johannes","first_name":"Johannes"},{"last_name":"Corvaglia","full_name":"Corvaglia, Valentina","first_name":"Valentina"},{"full_name":"Carell, Thomas","first_name":"Thomas","last_name":"Carell"},{"last_name":"Huc","full_name":"Huc, Ivan","first_name":"Ivan"}],"publication":"Angewandte Chemie International Edition","title":"Interfacing B‐DNA and DNA mimic foldamers","citation":{"apa":"Loos, M., Xu, F., Mandal, P. K., Chakrabortty, T., Douat, C., Konrad, D. B., … Huc, I. (2025). Interfacing B‐DNA and DNA mimic foldamers. <i>Angewandte Chemie International Edition</i>. Wiley. <a href=\"https://doi.org/10.1002/anie.202505273\">https://doi.org/10.1002/anie.202505273</a>","short":"M. Loos, F. Xu, P.K. Mandal, T. Chakrabortty, C. Douat, D.B. Konrad, M. Cabbar, J. Singer, V. Corvaglia, T. Carell, I. Huc, Angewandte Chemie International Edition 64 (2025).","mla":"Loos, Manuel, et al. “Interfacing B‐DNA and DNA Mimic Foldamers.” <i>Angewandte Chemie International Edition</i>, vol. 64, no. 31, e202505273, Wiley, 2025, doi:<a href=\"https://doi.org/10.1002/anie.202505273\">10.1002/anie.202505273</a>.","ama":"Loos M, Xu F, Mandal PK, et al. Interfacing B‐DNA and DNA mimic foldamers. <i>Angewandte Chemie International Edition</i>. 2025;64(31). doi:<a href=\"https://doi.org/10.1002/anie.202505273\">10.1002/anie.202505273</a>","ista":"Loos M, Xu F, Mandal PK, Chakrabortty T, Douat C, Konrad DB, Cabbar M, Singer J, Corvaglia V, Carell T, Huc I. 2025. Interfacing B‐DNA and DNA mimic foldamers. Angewandte Chemie International Edition. 64(31), e202505273.","chicago":"Loos, Manuel, Felix Xu, Pradeep K Mandal, Tulika Chakrabortty, Céline Douat, David B. Konrad, Melis Cabbar, et al. “Interfacing B‐DNA and DNA Mimic Foldamers.” <i>Angewandte Chemie International Edition</i>. Wiley, 2025. <a href=\"https://doi.org/10.1002/anie.202505273\">https://doi.org/10.1002/anie.202505273</a>.","ieee":"M. Loos <i>et al.</i>, “Interfacing B‐DNA and DNA mimic foldamers,” <i>Angewandte Chemie International Edition</i>, vol. 64, no. 31. Wiley, 2025."},"year":"2025","volume":64,"publisher":"Wiley","OA_place":"publisher","doi":"10.1002/anie.202505273","date_updated":"2026-01-19T11:07:53Z","pmid":1,"external_id":{"pmid":["40346004"]},"scopus_import":"1"},{"date_created":"2026-01-08T07:05:57Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","intvolume":"       146","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1021/jacs.4c09114"}],"month":"11","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"OA_type":"hybrid","oa":1,"PlanS_conform":"1","quality_controlled":"1","_id":"20961","day":"26","type":"journal_article","article_type":"original","language":[{"iso":"eng"}],"date_published":"2024-11-26T00:00:00Z","has_accepted_license":"1","abstract":[{"text":"Self-replicating molecules and well-defined folded macromolecules are of great significance in the emergence and evolution of life. How they may interconnect and affect each other remains largely elusive. Here, we demonstrate an abiotic system where a single building block can oligomerize to yield either a self-replicating molecule or a foldamer. Specifically, agitation of a disulfide-based dynamic combinatorial library at moderately elevated pH channels it selectively into a self-replicating hexamer assembled into fibers, after passing through a period where a 15-subunit macrocyclic foldamer existed transiently. Without mechanoagitation or at lower pH, the formation of hexamer fiber is suppressed, resulting in the accumulation of the 15mer foldamer. Foldamer and self-replicator can be interconverted in response to external stimuli, including agitation and a change in pH. Furthermore, upon the addition of a photoacid, the pH of the medium can be controlled by irradiation, driving the switching between replicator and foldamer and allowing a dissipative out-of-equilibrium state to be accessed, using light as a source of energy.","lang":"eng"}],"status":"public","publication_status":"published","article_processing_charge":"Yes (in subscription journal)","oa_version":"Published Version","extern":"1","publication_identifier":{"issn":["0002-7863"],"eissn":["1520-5126"]},"ddc":["540"],"issue":"49","publication":"Journal of the American Chemical Society","author":[{"last_name":"Jin","full_name":"Jin, Yulong","first_name":"Yulong"},{"full_name":"Mandal, Pradeep K","first_name":"Pradeep K","orcid":"0000-0001-5996-956X","last_name":"Mandal","id":"6a3def15-d4b4-11ef-9fa9-a24c1f545ec3"},{"last_name":"Wu","full_name":"Wu, Juntian","first_name":"Juntian"},{"full_name":"Kiani, Armin","first_name":"Armin","last_name":"Kiani"},{"last_name":"Zhao","first_name":"Rui","full_name":"Zhao, Rui"},{"first_name":"Ivan","full_name":"Huc, Ivan","last_name":"Huc"},{"last_name":"Otto","full_name":"Otto, Sijbren","first_name":"Sijbren"}],"fulldoi":"https://doi.org/10.1021/jacs.4c09114","page":"33395-33402","title":"Light-mediated interconversion between a foldamer and a self-replicator","publisher":"American Chemical Society","volume":146,"year":"2024","citation":{"ieee":"Y. Jin <i>et al.</i>, “Light-mediated interconversion between a foldamer and a self-replicator,” <i>Journal of the American Chemical Society</i>, vol. 146, no. 49. American Chemical Society, pp. 33395–33402, 2024.","chicago":"Jin, Yulong, Pradeep K Mandal, Juntian Wu, Armin Kiani, Rui Zhao, Ivan Huc, and Sijbren Otto. “Light-Mediated Interconversion between a Foldamer and a Self-Replicator.” <i>Journal of the American Chemical Society</i>. American Chemical Society, 2024. <a href=\"https://doi.org/10.1021/jacs.4c09114\">https://doi.org/10.1021/jacs.4c09114</a>.","ama":"Jin Y, Mandal PK, Wu J, et al. Light-mediated interconversion between a foldamer and a self-replicator. <i>Journal of the American Chemical Society</i>. 2024;146(49):33395-33402. doi:<a href=\"https://doi.org/10.1021/jacs.4c09114\">10.1021/jacs.4c09114</a>","ista":"Jin Y, Mandal PK, Wu J, Kiani A, Zhao R, Huc I, Otto S. 2024. Light-mediated interconversion between a foldamer and a self-replicator. Journal of the American Chemical Society. 146(49), 33395–33402.","mla":"Jin, Yulong, et al. “Light-Mediated Interconversion between a Foldamer and a Self-Replicator.” <i>Journal of the American Chemical Society</i>, vol. 146, no. 49, American Chemical Society, 2024, pp. 33395–402, doi:<a href=\"https://doi.org/10.1021/jacs.4c09114\">10.1021/jacs.4c09114</a>.","short":"Y. Jin, P.K. Mandal, J. Wu, A. Kiani, R. Zhao, I. Huc, S. Otto, Journal of the American Chemical Society 146 (2024) 33395–33402.","apa":"Jin, Y., Mandal, P. K., Wu, J., Kiani, A., Zhao, R., Huc, I., &#38; Otto, S. (2024). Light-mediated interconversion between a foldamer and a self-replicator. <i>Journal of the American Chemical Society</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/jacs.4c09114\">https://doi.org/10.1021/jacs.4c09114</a>"},"OA_place":"publisher","scopus_import":"1","pmid":1,"external_id":{"pmid":["39590511"]},"date_updated":"2026-01-19T11:03:31Z","doi":"10.1021/jacs.4c09114"},{"title":"Simultaneous formation of a foldamer and a self-replicator by out-of-equilibrium dynamic covalent chemistry","page":"33386-33394","fulldoi":"https://doi.org/10.1021/jacs.4c09111","publication":"Journal of the American Chemical Society","author":[{"last_name":"Sood","full_name":"Sood, Ankush","first_name":"Ankush"},{"full_name":"Mandal, Pradeep K","first_name":"Pradeep K","orcid":"0000-0001-5996-956X","id":"6a3def15-d4b4-11ef-9fa9-a24c1f545ec3","last_name":"Mandal"},{"first_name":"Jim","full_name":"Ottelé, Jim","last_name":"Ottelé"},{"first_name":"Juntian","full_name":"Wu, Juntian","last_name":"Wu"},{"first_name":"Marcel","full_name":"Eleveld, Marcel","last_name":"Eleveld"},{"first_name":"Joydev","full_name":"Hatai, Joydev","last_name":"Hatai"},{"last_name":"Pappas","full_name":"Pappas, Charalampos G.","first_name":"Charalampos G."},{"last_name":"Huc","full_name":"Huc, Ivan","first_name":"Ivan"},{"last_name":"Otto","first_name":"Sijbren","full_name":"Otto, Sijbren"}],"issue":"49","publication_identifier":{"issn":["0002-7863"],"eissn":["1520-5126"]},"doi":"10.1021/jacs.4c09111","date_updated":"2026-01-19T10:57:53Z","pmid":1,"external_id":{"pmid":["39590110"]},"scopus_import":"1","OA_place":"publisher","citation":{"mla":"Sood, Ankush, et al. “Simultaneous Formation of a Foldamer and a Self-Replicator by out-of-Equilibrium Dynamic Covalent Chemistry.” <i>Journal of the American Chemical Society</i>, vol. 146, no. 49, American Chemical Society, 2024, pp. 33386–94, doi:<a href=\"https://doi.org/10.1021/jacs.4c09111\">10.1021/jacs.4c09111</a>.","apa":"Sood, A., Mandal, P. K., Ottelé, J., Wu, J., Eleveld, M., Hatai, J., … Otto, S. (2024). Simultaneous formation of a foldamer and a self-replicator by out-of-equilibrium dynamic covalent chemistry. <i>Journal of the American Chemical Society</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/jacs.4c09111\">https://doi.org/10.1021/jacs.4c09111</a>","short":"A. Sood, P.K. Mandal, J. Ottelé, J. Wu, M. Eleveld, J. Hatai, C.G. Pappas, I. Huc, S. Otto, Journal of the American Chemical Society 146 (2024) 33386–33394.","chicago":"Sood, Ankush, Pradeep K Mandal, Jim Ottelé, Juntian Wu, Marcel Eleveld, Joydev Hatai, Charalampos G. Pappas, Ivan Huc, and Sijbren Otto. “Simultaneous Formation of a Foldamer and a Self-Replicator by out-of-Equilibrium Dynamic Covalent Chemistry.” <i>Journal of the American Chemical Society</i>. American Chemical Society, 2024. <a href=\"https://doi.org/10.1021/jacs.4c09111\">https://doi.org/10.1021/jacs.4c09111</a>.","ama":"Sood A, Mandal PK, Ottelé J, et al. Simultaneous formation of a foldamer and a self-replicator by out-of-equilibrium dynamic covalent chemistry. <i>Journal of the American Chemical Society</i>. 2024;146(49):33386-33394. doi:<a href=\"https://doi.org/10.1021/jacs.4c09111\">10.1021/jacs.4c09111</a>","ista":"Sood A, Mandal PK, Ottelé J, Wu J, Eleveld M, Hatai J, Pappas CG, Huc I, Otto S. 2024. Simultaneous formation of a foldamer and a self-replicator by out-of-equilibrium dynamic covalent chemistry. Journal of the American Chemical Society. 146(49), 33386–33394.","ieee":"A. Sood <i>et al.</i>, “Simultaneous formation of a foldamer and a self-replicator by out-of-equilibrium dynamic covalent chemistry,” <i>Journal of the American Chemical Society</i>, vol. 146, no. 49. American Chemical Society, pp. 33386–33394, 2024."},"year":"2024","publisher":"American Chemical Society","volume":146,"type":"journal_article","_id":"20962","day":"26","quality_controlled":"1","PlanS_conform":"1","oa":1,"OA_type":"hybrid","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"month":"11","main_file_link":[{"url":"https://doi.org/10.1021/jacs.4c09111","open_access":"1"}],"intvolume":"       146","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2026-01-08T07:06:27Z","keyword":["Fibers","Foldamers","Macrocycles","Monomers","Peptides","Proteins"],"extern":"1","oa_version":"Published Version","article_processing_charge":"Yes (in subscription journal)","publication_status":"published","abstract":[{"lang":"eng","text":"Systems chemistry has emerged as a useful paradigm to access structures and phenomena typically exhibited by living systems, including complex molecular systems such as self-replicators and foldamers. As we progress further toward the noncovalent synthesis of life-like systems, and eventually life itself, it is necessary to gain control over assembly pathways. Dissipative chemical fueling has enabled access to stable populations of (self-assembled) structures that would normally form only transiently. Here, we report a synthetic dynamic combinatorial library, made from a single structurally simple building block, from which a self-replicator and a foldamer can emerge along two distinct and competing pathways through an inter- or intramolecular assembly process, respectively. A fueled chemical reaction cycle is then set up to generate the foldamer transiently, in the presence of the self-replicator. The partitioning of the building block between the folding and self-replication pathways and the duration of the fueled reaction cycles are controlled by adjusting the amount of the chemical fuel. An out-of-equilibrium steady state involving the two assemblies could also be achieved by using a continuous stirred tank reactor with inflow and outflow of material. This work connects the domains of folding and self-replication in synthetic systems through dissipative out-of-equilibrium chemistry. It demonstrates that foldamers and self-replicators, formed from the same building block, can stably coexist if the system is continuously supplied with energy, while at equilibrium, the Gibbs phase rule prohibits such coexistence."}],"status":"public","has_accepted_license":"1","date_published":"2024-11-26T00:00:00Z","article_type":"original","language":[{"iso":"eng"}]},{"oa":1,"PlanS_conform":"1","quality_controlled":"1","type":"journal_article","_id":"20967","day":"30","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2026-01-11T14:32:23Z","month":"10","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1039/D4OB01436G"}],"intvolume":"        22","tmp":{"name":"Creative Commons Attribution 3.0 Unported (CC BY 3.0)","legal_code_url":"https://creativecommons.org/licenses/by/3.0/legalcode","image":"/images/cc_by.png","short":"CC BY (3.0)"},"OA_type":"hybrid","publication_status":"published","has_accepted_license":"1","abstract":[{"text":"A biotinylated helical aromatic oligoamide foldamer equivalent in size to a 24mer peptide was designed without any prejudice other than to display various polar and hydrophobic side chains at its surface. It was synthesized on solid phase, its P- and M-helical conformers were separated by HPLC on a chiral stationary phase, and the solid state structure of a non-biotinylated analogue was elucidated by X-ray crystallography. Pull-down experiments from a yeast cell lysate using the foldamer as a bait followed by proteomic analysis revealed potential protein binding partners. Three of these proteins were recombinantly expressed. Biolayer interferometry showed submicromolar binding demonstrating the potential of a given foldamer to have affinity for certain proteins in the absence of design considerations. Yet, binding selectivity was low in all three cases since both P- and M-conformers bound to the proteins with similar affinities.","lang":"eng"}],"status":"public","date_published":"2024-10-30T00:00:00Z","article_processing_charge":"Yes (in subscription journal)","oa_version":"Published Version","extern":"1","article_type":"original","language":[{"iso":"eng"}],"publication":"Organic & Biomolecular Chemistry","author":[{"first_name":"Sunbum","full_name":"Kwon, Sunbum","last_name":"Kwon"},{"first_name":"Vasily","full_name":"Morozov, Vasily","last_name":"Morozov"},{"last_name":"Wang","full_name":"Wang, Lingfei","first_name":"Lingfei"},{"last_name":"Mandal","id":"6a3def15-d4b4-11ef-9fa9-a24c1f545ec3","full_name":"Mandal, Pradeep K","first_name":"Pradeep K","orcid":"0000-0001-5996-956X"},{"last_name":"Chaignepain","full_name":"Chaignepain, Stéphane","first_name":"Stéphane"},{"full_name":"Douat, Céline","first_name":"Céline","last_name":"Douat"},{"last_name":"Huc","first_name":"Ivan","full_name":"Huc, Ivan"}],"fulldoi":"https://doi.org/10.1039/d4ob01436g","title":"Interrogating the potential of helical aromatic foldamers for protein recognition","page":"9342-9347","publication_identifier":{"issn":["1477-0520"],"eissn":["1477-0539"]},"license":"https://creativecommons.org/licenses/by/3.0/","issue":"48","scopus_import":"1","date_updated":"2026-01-20T06:56:44Z","doi":"10.1039/d4ob01436g","external_id":{"pmid":["39501876"]},"pmid":1,"publisher":"Royal Society of Chemistry","volume":22,"year":"2024","citation":{"apa":"Kwon, S., Morozov, V., Wang, L., Mandal, P. K., Chaignepain, S., Douat, C., &#38; Huc, I. (2024). Interrogating the potential of helical aromatic foldamers for protein recognition. <i>Organic &#38; Biomolecular Chemistry</i>. Royal Society of Chemistry. <a href=\"https://doi.org/10.1039/d4ob01436g\">https://doi.org/10.1039/d4ob01436g</a>","short":"S. Kwon, V. Morozov, L. Wang, P.K. Mandal, S. Chaignepain, C. Douat, I. Huc, Organic &#38; Biomolecular Chemistry 22 (2024) 9342–9347.","mla":"Kwon, Sunbum, et al. “Interrogating the Potential of Helical Aromatic Foldamers for Protein Recognition.” <i>Organic &#38; Biomolecular Chemistry</i>, vol. 22, no. 48, Royal Society of Chemistry, 2024, pp. 9342–47, doi:<a href=\"https://doi.org/10.1039/d4ob01436g\">10.1039/d4ob01436g</a>.","ista":"Kwon S, Morozov V, Wang L, Mandal PK, Chaignepain S, Douat C, Huc I. 2024. Interrogating the potential of helical aromatic foldamers for protein recognition. Organic &#38; Biomolecular Chemistry. 22(48), 9342–9347.","ama":"Kwon S, Morozov V, Wang L, et al. Interrogating the potential of helical aromatic foldamers for protein recognition. <i>Organic &#38; Biomolecular Chemistry</i>. 2024;22(48):9342-9347. doi:<a href=\"https://doi.org/10.1039/d4ob01436g\">10.1039/d4ob01436g</a>","chicago":"Kwon, Sunbum, Vasily Morozov, Lingfei Wang, Pradeep K Mandal, Stéphane Chaignepain, Céline Douat, and Ivan Huc. “Interrogating the Potential of Helical Aromatic Foldamers for Protein Recognition.” <i>Organic &#38; Biomolecular Chemistry</i>. Royal Society of Chemistry, 2024. <a href=\"https://doi.org/10.1039/d4ob01436g\">https://doi.org/10.1039/d4ob01436g</a>.","ieee":"S. Kwon <i>et al.</i>, “Interrogating the potential of helical aromatic foldamers for protein recognition,” <i>Organic &#38; Biomolecular Chemistry</i>, vol. 22, no. 48. Royal Society of Chemistry, pp. 9342–9347, 2024."},"OA_place":"publisher"},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2026-01-11T14:22:21Z","intvolume":"        62","month":"11","main_file_link":[{"url":"https://doi.org/10.1002/anie.202311639","open_access":"1"}],"tmp":{"short":"CC BY-NC (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","image":"/images/cc_by_nc.png"},"OA_type":"hybrid","oa":1,"quality_controlled":"1","day":"27","_id":"20966","type":"journal_article","article_number":"e202311639","article_type":"original","language":[{"iso":"eng"}],"date_published":"2023-11-27T00:00:00Z","publication_status":"published","status":"public","abstract":[{"text":"We prepared a series of water‐soluble aromatic oligoamide sequences all composed of a segment prone to form a single helix and a segment prone to dimerize into a double helix. These sequences exclusively assemble as antiparallel duplexes. The modification of the duplex inner rim by varying the nature of the substituents borne by the aromatic monomers allowed us to identify sequences that can hybridize by combining two chemically different strands, with high affinity and complete selectivity in water. X‐ray crystallography confirmed the expected antiparallel configuration of the duplexes whereas NMR spectroscopy and mass spectrometry allowed us to assess precisely the extent of the hybridization. The hybridization kinetics of the aromatic strands was shown to depend on both the nature of the substituents responsible for strand complementarity and the length of the aromatic strand. These results highlight the great potential of aromatic hetero‐duplex as a tool to construct non‐symmetrical dynamic supramolecular assemblies.","lang":"eng"}],"has_accepted_license":"1","article_processing_charge":"Yes (in subscription journal)","oa_version":"Published Version","extern":"1","publication_identifier":{"issn":["1433-7851"],"eissn":["1521-3773"]},"ddc":["540"],"license":"https://creativecommons.org/licenses/by-nc/4.0/","issue":"48","publication":"Angewandte Chemie International Edition","author":[{"last_name":"Koehler","full_name":"Koehler, Victor","first_name":"Victor"},{"first_name":"Gabrielle","full_name":"Bruschera, Gabrielle","last_name":"Bruschera"},{"full_name":"Merlet, Eric","first_name":"Eric","last_name":"Merlet"},{"id":"6a3def15-d4b4-11ef-9fa9-a24c1f545ec3","last_name":"Mandal","orcid":"0000-0001-5996-956X","first_name":"Pradeep K","full_name":"Mandal, Pradeep K"},{"first_name":"Estelle","full_name":"Morvan, Estelle","last_name":"Morvan"},{"last_name":"Rosu","full_name":"Rosu, Frédéric","first_name":"Frédéric"},{"last_name":"Douat","full_name":"Douat, Céline","first_name":"Céline"},{"last_name":"Fischer","first_name":"Lucile","full_name":"Fischer, Lucile"},{"first_name":"Ivan","full_name":"Huc, Ivan","last_name":"Huc"},{"last_name":"Ferrand","first_name":"Yann","full_name":"Ferrand, Yann"}],"fulldoi":"https://doi.org/10.1002/anie.202311639","title":"High‐affinity hybridization of complementary aromatic oligoamide strands in water","publisher":"Wiley","volume":62,"citation":{"ieee":"V. Koehler <i>et al.</i>, “High‐affinity hybridization of complementary aromatic oligoamide strands in water,” <i>Angewandte Chemie International Edition</i>, vol. 62, no. 48. Wiley, 2023.","ista":"Koehler V, Bruschera G, Merlet E, Mandal PK, Morvan E, Rosu F, Douat C, Fischer L, Huc I, Ferrand Y. 2023. High‐affinity hybridization of complementary aromatic oligoamide strands in water. Angewandte Chemie International Edition. 62(48), e202311639.","ama":"Koehler V, Bruschera G, Merlet E, et al. High‐affinity hybridization of complementary aromatic oligoamide strands in water. <i>Angewandte Chemie International Edition</i>. 2023;62(48). doi:<a href=\"https://doi.org/10.1002/anie.202311639\">10.1002/anie.202311639</a>","chicago":"Koehler, Victor, Gabrielle Bruschera, Eric Merlet, Pradeep K Mandal, Estelle Morvan, Frédéric Rosu, Céline Douat, Lucile Fischer, Ivan Huc, and Yann Ferrand. “High‐affinity Hybridization of Complementary Aromatic Oligoamide Strands in Water.” <i>Angewandte Chemie International Edition</i>. Wiley, 2023. <a href=\"https://doi.org/10.1002/anie.202311639\">https://doi.org/10.1002/anie.202311639</a>.","short":"V. Koehler, G. Bruschera, E. Merlet, P.K. Mandal, E. Morvan, F. Rosu, C. Douat, L. Fischer, I. Huc, Y. Ferrand, Angewandte Chemie International Edition 62 (2023).","apa":"Koehler, V., Bruschera, G., Merlet, E., Mandal, P. K., Morvan, E., Rosu, F., … Ferrand, Y. (2023). High‐affinity hybridization of complementary aromatic oligoamide strands in water. <i>Angewandte Chemie International Edition</i>. Wiley. <a href=\"https://doi.org/10.1002/anie.202311639\">https://doi.org/10.1002/anie.202311639</a>","mla":"Koehler, Victor, et al. “High‐affinity Hybridization of Complementary Aromatic Oligoamide Strands in Water.” <i>Angewandte Chemie International Edition</i>, vol. 62, no. 48, e202311639, Wiley, 2023, doi:<a href=\"https://doi.org/10.1002/anie.202311639\">10.1002/anie.202311639</a>."},"year":"2023","OA_place":"publisher","scopus_import":"1","pmid":1,"external_id":{"pmid":["37804233"]},"date_updated":"2026-01-19T11:58:27Z","doi":"10.1002/anie.202311639"},{"extern":"1","oa_version":"Published Version","article_processing_charge":"Yes","date_published":"2023-09-25T00:00:00Z","abstract":[{"lang":"eng","text":"Several helically folded aromatic oligoamides were designed and synthesized. The sequences were all water-soluble thanks to the charged side chains borne by the monomers. Replacing a few, sometimes only two, charged side chains by neutral methoxy groups was shown to trigger the formation of various aggregates which could be tentatively assigned to head-to-head stacked dimers of single helices, double helical duplexes and a quadruplex, none of which would form in organic solvent with organic-soluble analogues. The nature of the aggregates was supported by concentration and solvent dependent NMR studies, 1H DOSY experiments, mass spectrometry, and X-ray crystallography or energy-minimized models, as well as analogies with earlier studies. The hydrophobic effect appears to be the main driving force for aggregation but it can be finely modulated by the presence or absence of a small number of charges to an extent that had no precedent in aromatic foldamer architectures. These results will serve as a benchmark for future foldamer design in water."}],"publication_status":"published","status":"public","has_accepted_license":"1","article_type":"original","language":[{"iso":"eng"}],"type":"journal_article","_id":"20968","day":"25","quality_controlled":"1","PlanS_conform":"1","oa":1,"DOAJ_listed":"1","OA_type":"gold","tmp":{"short":"CC BY-NC (3.0)","image":"/images/cc_by_nc.png","legal_code_url":"https://creativecommons.org/licenses/by-nc/3.0/legalcode","name":"Creative Commons Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0)"},"intvolume":"        14","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1039/D3SC02020G"}],"month":"09","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2026-01-11T14:35:50Z","pmid":1,"external_id":{"pmid":["37860656"]},"date_updated":"2026-01-20T07:00:50Z","doi":"10.1039/d3sc02020g","scopus_import":"1","OA_place":"publisher","citation":{"mla":"Teng, Binhao, et al. “Controlling Aromatic Helix Dimerization in Water by Tuning Charge Repulsions.” <i>Chemical Science</i>, vol. 14, no. 40, Royal Society of Chemistry, 2023, pp. 11251–60, doi:<a href=\"https://doi.org/10.1039/d3sc02020g\">10.1039/d3sc02020g</a>.","short":"B. Teng, P.K. Mandal, L. Allmendinger, C. Douat, Y. Ferrand, I. Huc, Chemical Science 14 (2023) 11251–11260.","apa":"Teng, B., Mandal, P. K., Allmendinger, L., Douat, C., Ferrand, Y., &#38; Huc, I. (2023). Controlling aromatic helix dimerization in water by tuning charge repulsions. <i>Chemical Science</i>. Royal Society of Chemistry. <a href=\"https://doi.org/10.1039/d3sc02020g\">https://doi.org/10.1039/d3sc02020g</a>","ieee":"B. Teng, P. K. Mandal, L. Allmendinger, C. Douat, Y. Ferrand, and I. Huc, “Controlling aromatic helix dimerization in water by tuning charge repulsions,” <i>Chemical Science</i>, vol. 14, no. 40. Royal Society of Chemistry, pp. 11251–11260, 2023.","chicago":"Teng, Binhao, Pradeep K Mandal, Lars Allmendinger, Céline Douat, Yann Ferrand, and Ivan Huc. “Controlling Aromatic Helix Dimerization in Water by Tuning Charge Repulsions.” <i>Chemical Science</i>. Royal Society of Chemistry, 2023. <a href=\"https://doi.org/10.1039/d3sc02020g\">https://doi.org/10.1039/d3sc02020g</a>.","ama":"Teng B, Mandal PK, Allmendinger L, Douat C, Ferrand Y, Huc I. Controlling aromatic helix dimerization in water by tuning charge repulsions. <i>Chemical Science</i>. 2023;14(40):11251-11260. doi:<a href=\"https://doi.org/10.1039/d3sc02020g\">10.1039/d3sc02020g</a>","ista":"Teng B, Mandal PK, Allmendinger L, Douat C, Ferrand Y, Huc I. 2023. Controlling aromatic helix dimerization in water by tuning charge repulsions. Chemical Science. 14(40), 11251–11260."},"year":"2023","publisher":"Royal Society of Chemistry","volume":14,"page":"11251-11260","title":"Controlling aromatic helix dimerization in water by tuning charge repulsions","fulldoi":"https://doi.org/10.1039/d3sc02020g","author":[{"last_name":"Teng","first_name":"Binhao","full_name":"Teng, Binhao"},{"full_name":"Mandal, Pradeep K","orcid":"0000-0001-5996-956X","first_name":"Pradeep K","last_name":"Mandal","id":"6a3def15-d4b4-11ef-9fa9-a24c1f545ec3"},{"full_name":"Allmendinger, Lars","first_name":"Lars","last_name":"Allmendinger"},{"last_name":"Douat","first_name":"Céline","full_name":"Douat, Céline"},{"last_name":"Ferrand","first_name":"Yann","full_name":"Ferrand, Yann"},{"last_name":"Huc","full_name":"Huc, Ivan","first_name":"Ivan"}],"publication":"Chemical Science","issue":"40","license":"https://creativecommons.org/licenses/by-nc/3.0/","ddc":["540"],"publication_identifier":{"issn":["2041-6520"],"eissn":["2041-6539"]}},{"scopus_import":"1","external_id":{"pmid":["37416699"]},"pmid":1,"date_updated":"2026-01-20T07:04:16Z","doi":"10.1039/d3sc01235b","volume":14,"publisher":"Royal Society of Chemistry","year":"2023","citation":{"short":"Y. Zhang, B. Ourri, P.-T. Skowron, E. Jeamet, T. Chetot, C. Duchamp, A.M. Belenguer, N. Vanthuyne, O. Cala, E. Dumont, P.K. Mandal, I. Huc, F. Perret, L. Vial, J. Leclaire, Chemical Science 14 (2023) 7126–7135.","apa":"Zhang, Y., Ourri, B., Skowron, P.-T., Jeamet, E., Chetot, T., Duchamp, C., … Leclaire, J. (2023). Self-assembly of achiral building blocks into chiral cyclophanes using non-directional interactions. <i>Chemical Science</i>. Royal Society of Chemistry. <a href=\"https://doi.org/10.1039/d3sc01235b\">https://doi.org/10.1039/d3sc01235b</a>","mla":"Zhang, Yuan, et al. “Self-Assembly of Achiral Building Blocks into Chiral Cyclophanes Using Non-Directional Interactions.” <i>Chemical Science</i>, vol. 14, no. 26, Royal Society of Chemistry, 2023, pp. 7126–35, doi:<a href=\"https://doi.org/10.1039/d3sc01235b\">10.1039/d3sc01235b</a>.","ieee":"Y. Zhang <i>et al.</i>, “Self-assembly of achiral building blocks into chiral cyclophanes using non-directional interactions,” <i>Chemical Science</i>, vol. 14, no. 26. Royal Society of Chemistry, pp. 7126–7135, 2023.","ista":"Zhang Y, Ourri B, Skowron P-T, Jeamet E, Chetot T, Duchamp C, Belenguer AM, Vanthuyne N, Cala O, Dumont E, Mandal PK, Huc I, Perret F, Vial L, Leclaire J. 2023. Self-assembly of achiral building blocks into chiral cyclophanes using non-directional interactions. Chemical Science. 14(26), 7126–7135.","ama":"Zhang Y, Ourri B, Skowron P-T, et al. Self-assembly of achiral building blocks into chiral cyclophanes using non-directional interactions. <i>Chemical Science</i>. 2023;14(26):7126-7135. doi:<a href=\"https://doi.org/10.1039/d3sc01235b\">10.1039/d3sc01235b</a>","chicago":"Zhang, Yuan, Benjamin Ourri, Pierre-Thomas Skowron, Emeric Jeamet, Titouan Chetot, Christian Duchamp, Ana M. Belenguer, et al. “Self-Assembly of Achiral Building Blocks into Chiral Cyclophanes Using Non-Directional Interactions.” <i>Chemical Science</i>. Royal Society of Chemistry, 2023. <a href=\"https://doi.org/10.1039/d3sc01235b\">https://doi.org/10.1039/d3sc01235b</a>."},"OA_place":"publisher","publication":"Chemical Science","author":[{"last_name":"Zhang","first_name":"Yuan","full_name":"Zhang, Yuan"},{"last_name":"Ourri","full_name":"Ourri, Benjamin","first_name":"Benjamin"},{"last_name":"Skowron","first_name":"Pierre-Thomas","full_name":"Skowron, Pierre-Thomas"},{"first_name":"Emeric","full_name":"Jeamet, Emeric","last_name":"Jeamet"},{"full_name":"Chetot, Titouan","first_name":"Titouan","last_name":"Chetot"},{"first_name":"Christian","full_name":"Duchamp, Christian","last_name":"Duchamp"},{"last_name":"Belenguer","full_name":"Belenguer, Ana M.","first_name":"Ana M."},{"full_name":"Vanthuyne, Nicolas","first_name":"Nicolas","last_name":"Vanthuyne"},{"full_name":"Cala, Olivier","first_name":"Olivier","last_name":"Cala"},{"last_name":"Dumont","full_name":"Dumont, Elise","first_name":"Elise"},{"last_name":"Mandal","id":"6a3def15-d4b4-11ef-9fa9-a24c1f545ec3","full_name":"Mandal, Pradeep K","orcid":"0000-0001-5996-956X","first_name":"Pradeep K"},{"last_name":"Huc","first_name":"Ivan","full_name":"Huc, Ivan"},{"first_name":"Florent","full_name":"Perret, Florent","last_name":"Perret"},{"first_name":"Laurent","full_name":"Vial, Laurent","last_name":"Vial"},{"last_name":"Leclaire","full_name":"Leclaire, Julien","first_name":"Julien"}],"fulldoi":"https://doi.org/10.1039/d3sc01235b","page":"7126-7135","title":"Self-assembly of achiral building blocks into chiral cyclophanes using non-directional interactions","publication_identifier":{"eissn":["2041-6539"],"issn":["2041-6520"]},"ddc":["540"],"issue":"26","date_published":"2023-05-24T00:00:00Z","status":"public","has_accepted_license":"1","publication_status":"published","abstract":[{"lang":"eng","text":"The diastereoselective assembly of achiral constituents through a single spontaneous process into complex covalent architectures bearing multiple stereogenic elements still remains a challenge for synthetic chemists. Here, we show that such an extreme level of control can be achieved by implementing stereo-electronic information on synthetic organic building blocks and templates and that non-directional interactions (i.e., electrostatic and steric interactions) can transfer this information to deliver, after self-assembly, high-molecular weight macrocyclic species carrying up to 16 stereogenic elements. Beyond the field of supramolecular chemistry, this proof of concept should stimulate the on-demand production of highly structured polyfunctional architectures."}],"article_processing_charge":"Yes","oa_version":"Published Version","extern":"1","language":[{"iso":"eng"}],"article_type":"original","DOAJ_listed":"1","oa":1,"quality_controlled":"1","_id":"20969","type":"journal_article","day":"24","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2026-01-11T14:38:38Z","intvolume":"        14","month":"05","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1039/D3SC01235B"}],"tmp":{"short":"CC BY-NC (3.0)","image":"/images/cc_by_nc.png","legal_code_url":"https://creativecommons.org/licenses/by-nc/3.0/legalcode","name":"Creative Commons Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0)"},"OA_type":"gold"},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2026-01-11T14:41:26Z","month":"01","main_file_link":[{"url":"https://doi.org/10.1021/jacs.2c09325","open_access":"1"}],"intvolume":"       145","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"OA_type":"hybrid","oa":1,"PlanS_conform":"1","quality_controlled":"1","_id":"20970","type":"journal_article","day":"27","language":[{"iso":"eng"}],"article_type":"original","status":"public","has_accepted_license":"1","abstract":[{"lang":"eng","text":"Dynamic foldamers are synthetic folded molecules which can change their conformation in response to an external stimulus and are currently at the forefront of foldamer chemistry. However, constitutionally dynamic foldamers, which can change not only their conformation but also their molecular constitution in response to their environment, are without precedent. We now report a size- and shape-switching small dynamic covalent foldamer network which responds to changes in pH. Specifically, acidic conditions direct the oligomerization of a dipeptide-based building block into a 16-subunit macrocycle with well-defined conformation and with high selectivity. At higher pH the same building block yields another cyclic foldamer with a smaller ring size (9mer). The two foldamers readily and repeatedly interconvert upon adjustment of the pH of the solution. We have previously shown that addition of a template can direct oligomerization of the same building block to yet other rings sizes (including a 12mer and a 13mer, accompanied by a minor amount of 14mer). This brings the total number of discrete foldamers that can be accessed from a single building block to five. For a single building block system to exhibit such highly diverse structure space is unique and sets this system of foldamers apart from proteins. Furthermore, the emergence of constitutional dynamicity opens up new avenues to foldamers with adaptive behavior."}],"publication_status":"published","date_published":"2023-01-27T00:00:00Z","article_processing_charge":"Yes (in subscription journal)","oa_version":"Published Version","extern":"1","publication_identifier":{"eissn":["1520-5126"],"issn":["0002-7863"]},"ddc":["540"],"issue":"5","author":[{"last_name":"Jin","full_name":"Jin, Yulong","first_name":"Yulong"},{"id":"6a3def15-d4b4-11ef-9fa9-a24c1f545ec3","last_name":"Mandal","full_name":"Mandal, Pradeep K","first_name":"Pradeep K","orcid":"0000-0001-5996-956X"},{"last_name":"Wu","first_name":"Juntian","full_name":"Wu, Juntian"},{"last_name":"Böcher","first_name":"Niklas","full_name":"Böcher, Niklas"},{"last_name":"Huc","full_name":"Huc, Ivan","first_name":"Ivan"},{"first_name":"Sijbren","full_name":"Otto, Sijbren","last_name":"Otto"}],"publication":"Journal of the American Chemical Society","fulldoi":"https://doi.org/10.1021/jacs.2c09325","title":"(Re-)directing oligomerization of a single building block into two specific dynamic covalent foldamers through pH","page":"2822-2829","publisher":"American Chemical Society","volume":145,"year":"2023","citation":{"chicago":"Jin, Yulong, Pradeep K Mandal, Juntian Wu, Niklas Böcher, Ivan Huc, and Sijbren Otto. “(Re-)Directing Oligomerization of a Single Building Block into Two Specific Dynamic Covalent Foldamers through PH.” <i>Journal of the American Chemical Society</i>. American Chemical Society, 2023. <a href=\"https://doi.org/10.1021/jacs.2c09325\">https://doi.org/10.1021/jacs.2c09325</a>.","ama":"Jin Y, Mandal PK, Wu J, Böcher N, Huc I, Otto S. (Re-)directing oligomerization of a single building block into two specific dynamic covalent foldamers through pH. <i>Journal of the American Chemical Society</i>. 2023;145(5):2822-2829. doi:<a href=\"https://doi.org/10.1021/jacs.2c09325\">10.1021/jacs.2c09325</a>","ista":"Jin Y, Mandal PK, Wu J, Böcher N, Huc I, Otto S. 2023. (Re-)directing oligomerization of a single building block into two specific dynamic covalent foldamers through pH. Journal of the American Chemical Society. 145(5), 2822–2829.","ieee":"Y. Jin, P. K. Mandal, J. Wu, N. Böcher, I. Huc, and S. Otto, “(Re-)directing oligomerization of a single building block into two specific dynamic covalent foldamers through pH,” <i>Journal of the American Chemical Society</i>, vol. 145, no. 5. American Chemical Society, pp. 2822–2829, 2023.","mla":"Jin, Yulong, et al. “(Re-)Directing Oligomerization of a Single Building Block into Two Specific Dynamic Covalent Foldamers through PH.” <i>Journal of the American Chemical Society</i>, vol. 145, no. 5, American Chemical Society, 2023, pp. 2822–29, doi:<a href=\"https://doi.org/10.1021/jacs.2c09325\">10.1021/jacs.2c09325</a>.","short":"Y. Jin, P.K. Mandal, J. Wu, N. Böcher, I. Huc, S. Otto, Journal of the American Chemical Society 145 (2023) 2822–2829.","apa":"Jin, Y., Mandal, P. K., Wu, J., Böcher, N., Huc, I., &#38; Otto, S. (2023). (Re-)directing oligomerization of a single building block into two specific dynamic covalent foldamers through pH. <i>Journal of the American Chemical Society</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/jacs.2c09325\">https://doi.org/10.1021/jacs.2c09325</a>"},"OA_place":"publisher","scopus_import":"1","doi":"10.1021/jacs.2c09325","date_updated":"2026-01-20T07:15:32Z","external_id":{"pmid":["36705469"]},"pmid":1},{"month":"06","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1107/S2059798322003928"}],"intvolume":"        78","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2026-01-29T14:59:50Z","OA_type":"hybrid","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"oa":1,"day":"01","_id":"21078","type":"journal_article","quality_controlled":"1","language":[{"iso":"eng"}],"article_type":"original","article_processing_charge":"No","status":"public","has_accepted_license":"1","publication_status":"published","abstract":[{"text":"The ease with which racemic mixtures crystallize compared with the equivalent chiral systems is routinely taken advantage of to produce crystals of small molecules. However, biological macromolecules such as DNA and proteins are naturally chiral, and thus the limited range of chiral space groups available hampers the crystallization of such molecules. Inspiring work over the past 15 years has shown that racemic mixtures of proteins, which were made possible by impressive advances in protein chemical synthesis, can indeed improve the success rate of protein crystallization experiments. More recently, the racemic crystallization approach was extended to include nucleic acids as a possible aid in the determination of enantiopure DNA crystal structures. Here, findings are reported that suggest that the benefits may extend beyond this. Two racemic crystal structures of the DNA sequence d(CCCGGG) are described which were found to fold into A-form DNA. This form differs from the Z-form DNA conformation adopted by the chiral equivalent in the solid state, suggesting that the use of racemates may also favour the emergence of new conformations. Importantly, the racemic mixture forms interactions in the solid state that differ from the chiral equivalent (including the formation of racemic pseudo-helices), suggesting that the use of racemic DNA mixtures could provide new possibilities for the design of precise self-assembled nanomaterials and nanostructures.","lang":"eng"}],"date_published":"2022-06-01T00:00:00Z","extern":"1","oa_version":"Published Version","publication_identifier":{"eissn":["2059-7983"]},"issue":"6","ddc":["570"],"fulldoi":"https://doi.org/10.1107/s2059798322003928","author":[{"first_name":"Pradeep K","orcid":"0000-0001-5996-956X","full_name":"Mandal, Pradeep K","id":"6a3def15-d4b4-11ef-9fa9-a24c1f545ec3","last_name":"Mandal"},{"last_name":"Collie","full_name":"Collie, Gavin W.","first_name":"Gavin W."},{"first_name":"Brice","full_name":"Kauffmann, Brice","last_name":"Kauffmann"},{"full_name":"Huc, Ivan","first_name":"Ivan","last_name":"Huc"}],"publication":"Acta Crystallographica Section D Structural Biology","title":"Racemic crystal structures of A-DNA duplexes","page":"709-715","citation":{"apa":"Mandal, P. K., Collie, G. W., Kauffmann, B., &#38; Huc, I. (2022). Racemic crystal structures of A-DNA duplexes. <i>Acta Crystallographica Section D Structural Biology</i>. International Union of Crystallography. <a href=\"https://doi.org/10.1107/s2059798322003928\">https://doi.org/10.1107/s2059798322003928</a>","short":"P.K. Mandal, G.W. Collie, B. Kauffmann, I. Huc, Acta Crystallographica Section D Structural Biology 78 (2022) 709–715.","mla":"Mandal, Pradeep K., et al. “Racemic Crystal Structures of A-DNA Duplexes.” <i>Acta Crystallographica Section D Structural Biology</i>, vol. 78, no. 6, International Union of Crystallography, 2022, pp. 709–15, doi:<a href=\"https://doi.org/10.1107/s2059798322003928\">10.1107/s2059798322003928</a>.","ista":"Mandal PK, Collie GW, Kauffmann B, Huc I. 2022. Racemic crystal structures of A-DNA duplexes. Acta Crystallographica Section D Structural Biology. 78(6), 709–715.","ama":"Mandal PK, Collie GW, Kauffmann B, Huc I. Racemic crystal structures of A-DNA duplexes. <i>Acta Crystallographica Section D Structural Biology</i>. 2022;78(6):709-715. doi:<a href=\"https://doi.org/10.1107/s2059798322003928\">10.1107/s2059798322003928</a>","chicago":"Mandal, Pradeep K, Gavin W. Collie, Brice Kauffmann, and Ivan Huc. “Racemic Crystal Structures of A-DNA Duplexes.” <i>Acta Crystallographica Section D Structural Biology</i>. International Union of Crystallography, 2022. <a href=\"https://doi.org/10.1107/s2059798322003928\">https://doi.org/10.1107/s2059798322003928</a>.","ieee":"P. K. Mandal, G. W. Collie, B. Kauffmann, and I. Huc, “Racemic crystal structures of A-DNA duplexes,” <i>Acta Crystallographica Section D Structural Biology</i>, vol. 78, no. 6. International Union of Crystallography, pp. 709–715, 2022."},"year":"2022","publisher":"International Union of Crystallography","volume":78,"OA_place":"publisher","doi":"10.1107/s2059798322003928","date_updated":"2026-02-24T07:08:58Z","external_id":{"pmid":["35647918"]},"pmid":1},{"tmp":{"short":"CC BY-NC (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","image":"/images/cc_by_nc.png"},"OA_type":"hybrid","date_created":"2026-01-29T15:05:40Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","intvolume":"        28","month":"06","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1002/chem.202200538"}],"quality_controlled":"1","day":"01","_id":"21079","type":"journal_article","oa":1,"article_number":"e202200538","language":[{"iso":"eng"}],"article_type":"original","oa_version":"Published Version","extern":"1","date_published":"2022-06-01T00:00:00Z","has_accepted_license":"1","abstract":[{"text":"<jats:title>Abstract</jats:title><jats:p>A series of aromatic oligoamide foldamer sequences containing different proportions of three δ‐amino acids derived from quinoline, pyridine, and benzene and possessing varying flexibility, for example due to methylene bridges, were synthesized. Crystallographic structures of two key sequences and <jats:sup>1</jats:sup>H NMR data in water concur to show that a canonical aromatic helix fold prevails in almost all cases and that helix stability critically depends on the ratio between rigid and flexible units. Notwithstanding subtle variations of curvature, i. e. the numbers of units per turn, the aromatic δ‐peptide helix is therefore shown to be general and tolerant of a great number of sp<jats:sup>3</jats:sup> centers. We also demonstrate canonical helical folding upon alternating two monomers that do not promote folding when taken separately: folding occurs with two methylenes between every other unit, not with one methylene between every unit. These findings highlight that a fine‐tuning of helix handedness inversion kinetics, curvature, and side chain positioning in aromatic δ‐peptidic foldamers can be realized by systematically combining different yet compatible δ‐amino acids.</jats:p>","lang":"eng"}],"publication_status":"published","status":"public","article_processing_charge":"No","ddc":["540"],"issue":"31","publication_identifier":{"issn":["0947-6539"],"eissn":["1521-3765"]},"title":"Generalizing the aromatic δ‐amino acid foldamer helix","publication":"Chemistry – A European Journal","author":[{"last_name":"Bindl","first_name":"Daniel","full_name":"Bindl, Daniel"},{"first_name":"Pradeep K","orcid":"0000-0001-5996-956X","full_name":"Mandal, Pradeep K","id":"6a3def15-d4b4-11ef-9fa9-a24c1f545ec3","last_name":"Mandal"},{"last_name":"Huc","full_name":"Huc, Ivan","first_name":"Ivan"}],"fulldoi":"https://doi.org/10.1002/chem.202200538","OA_place":"publisher","publisher":"Wiley","volume":28,"year":"2022","citation":{"short":"D. Bindl, P.K. Mandal, I. Huc, Chemistry – A European Journal 28 (2022).","apa":"Bindl, D., Mandal, P. K., &#38; Huc, I. (2022). Generalizing the aromatic δ‐amino acid foldamer helix. <i>Chemistry – A European Journal</i>. Wiley. <a href=\"https://doi.org/10.1002/chem.202200538\">https://doi.org/10.1002/chem.202200538</a>","mla":"Bindl, Daniel, et al. “Generalizing the Aromatic Δ‐amino Acid Foldamer Helix.” <i>Chemistry – A European Journal</i>, vol. 28, no. 31, e202200538, Wiley, 2022, doi:<a href=\"https://doi.org/10.1002/chem.202200538\">10.1002/chem.202200538</a>.","ama":"Bindl D, Mandal PK, Huc I. Generalizing the aromatic δ‐amino acid foldamer helix. <i>Chemistry – A European Journal</i>. 2022;28(31). doi:<a href=\"https://doi.org/10.1002/chem.202200538\">10.1002/chem.202200538</a>","ista":"Bindl D, Mandal PK, Huc I. 2022. Generalizing the aromatic δ‐amino acid foldamer helix. Chemistry – A European Journal. 28(31), e202200538.","chicago":"Bindl, Daniel, Pradeep K Mandal, and Ivan Huc. “Generalizing the Aromatic Δ‐amino Acid Foldamer Helix.” <i>Chemistry – A European Journal</i>. Wiley, 2022. <a href=\"https://doi.org/10.1002/chem.202200538\">https://doi.org/10.1002/chem.202200538</a>.","ieee":"D. Bindl, P. K. Mandal, and I. Huc, “Generalizing the aromatic δ‐amino acid foldamer helix,” <i>Chemistry – A European Journal</i>, vol. 28, no. 31. Wiley, 2022."},"pmid":1,"external_id":{"pmid":["35332956"]},"date_updated":"2026-02-20T07:04:18Z","doi":"10.1002/chem.202200538"},{"article_type":"original","language":[{"iso":"eng"}],"article_number":"e202116509","article_processing_charge":"No","date_published":"2022-03-07T00:00:00Z","has_accepted_license":"1","abstract":[{"lang":"eng","text":"Tight binding was observed between the C‐terminal cross section of aromatic oligoamide helices in aqueous solution, leading to the formation of discrete head‐to‐head dimers in slow exchange on the NMR timescale with the corresponding monomers. The nature and structure of the dimers was evidenced by 2D NOESY and DOSY spectroscopy, mass spectrometry and X‐ray crystallography. The binding interface involves a large hydrophobic aromatic surface and hydrogen bonding. Dimerization requires that helices have the same handedness and the presence of a C‐terminal carboxy function. The protonation state of the carboxy group plays a crucial role, resulting in pH dependence of the association. Dimerization is also influenced by neighboring side chains and can be programmed to selectively produce heteromeric aggregates."}],"status":"public","publication_status":"published","extern":"1","oa_version":"Published Version","intvolume":"        61","month":"03","main_file_link":[{"url":"https://doi.org/10.1002/anie.202116509","open_access":"1"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2026-01-29T15:08:44Z","OA_type":"hybrid","tmp":{"short":"CC BY-NC (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","image":"/images/cc_by_nc.png"},"oa":1,"day":"07","_id":"21080","type":"journal_article","quality_controlled":"1","year":"2022","citation":{"ieee":"D. Bindl, P. K. Mandal, L. Allmendinger, and I. Huc, “Discrete stacked dimers of aromatic oligoamide helices,” <i>Angewandte Chemie International Edition</i>, vol. 61, no. 11. Wiley, 2022.","chicago":"Bindl, Daniel, Pradeep K Mandal, Lars Allmendinger, and Ivan Huc. “Discrete Stacked Dimers of Aromatic Oligoamide Helices.” <i>Angewandte Chemie International Edition</i>. Wiley, 2022. <a href=\"https://doi.org/10.1002/anie.202116509\">https://doi.org/10.1002/anie.202116509</a>.","ama":"Bindl D, Mandal PK, Allmendinger L, Huc I. Discrete stacked dimers of aromatic oligoamide helices. <i>Angewandte Chemie International Edition</i>. 2022;61(11). doi:<a href=\"https://doi.org/10.1002/anie.202116509\">10.1002/anie.202116509</a>","ista":"Bindl D, Mandal PK, Allmendinger L, Huc I. 2022. Discrete stacked dimers of aromatic oligoamide helices. Angewandte Chemie International Edition. 61(11), e202116509.","mla":"Bindl, Daniel, et al. “Discrete Stacked Dimers of Aromatic Oligoamide Helices.” <i>Angewandte Chemie International Edition</i>, vol. 61, no. 11, e202116509, Wiley, 2022, doi:<a href=\"https://doi.org/10.1002/anie.202116509\">10.1002/anie.202116509</a>.","apa":"Bindl, D., Mandal, P. K., Allmendinger, L., &#38; Huc, I. (2022). Discrete stacked dimers of aromatic oligoamide helices. <i>Angewandte Chemie International Edition</i>. Wiley. <a href=\"https://doi.org/10.1002/anie.202116509\">https://doi.org/10.1002/anie.202116509</a>","short":"D. Bindl, P.K. Mandal, L. Allmendinger, I. Huc, Angewandte Chemie International Edition 61 (2022)."},"publisher":"Wiley","volume":61,"OA_place":"publisher","pmid":1,"external_id":{"pmid":["34962351 "]},"doi":"10.1002/anie.202116509","date_updated":"2026-02-20T07:06:47Z","publication_identifier":{"issn":["1433-7851"],"eissn":["1521-3773"]},"issue":"11","fulldoi":"https://doi.org/10.1002/anie.202116509","author":[{"full_name":"Bindl, Daniel","first_name":"Daniel","last_name":"Bindl"},{"id":"6a3def15-d4b4-11ef-9fa9-a24c1f545ec3","last_name":"Mandal","full_name":"Mandal, Pradeep K","orcid":"0000-0001-5996-956X","first_name":"Pradeep K"},{"first_name":"Lars","full_name":"Allmendinger, Lars","last_name":"Allmendinger"},{"last_name":"Huc","first_name":"Ivan","full_name":"Huc, Ivan"}],"publication":"Angewandte Chemie International Edition","title":"Discrete stacked dimers of aromatic oligoamide helices"},{"language":[{"iso":"eng"}],"article_type":"original","extern":"1","oa_version":"Published Version","article_processing_charge":"Yes","abstract":[{"lang":"eng","text":"Macrocyclic peptides are an important class of bioactive substances. When inserting an aromatic foldamer segment in a macrocyclic peptide, the strong folding propensity of the former may influence the conformation and alter the properties of the latter. Such an insertion is relevant because some foldamer–peptide hybrids have recently been shown to be tolerated by the ribosome, prior to forming macrocycles, and can thus be produced using an in vitro translation system. We have investigated the interplay of peptide and foldamer conformations in such hybrid macrocycles. We show that foldamer helical folding always prevails and stands as a viable means to stretch, i.e. unfold, peptides in a solvent dependent manner. Conversely, the peptide systematically has a reciprocal influence and gives rise to strong foldamer helix handedness bias as well as foldamer helix stabilisation. The hybrid macrocycles also show resistance towards proteolytic degradation."}],"has_accepted_license":"1","status":"public","publication_status":"published","date_published":"2021-07-27T00:00:00Z","OA_type":"gold","tmp":{"short":"CC BY-NC (3.0)","image":"/images/cc_by_nc.png","legal_code_url":"https://creativecommons.org/licenses/by-nc/3.0/legalcode","name":"Creative Commons Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0)"},"month":"07","main_file_link":[{"url":"https://doi.org/10.1039/D1SC03640H","open_access":"1"}],"intvolume":"        12","date_created":"2026-01-29T15:15:12Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","type":"journal_article","_id":"21081","day":"27","quality_controlled":"1","oa":1,"OA_place":"publisher","year":"2021","citation":{"ieee":"S. Dengler, P. K. Mandal, L. Allmendinger, C. Douat, and I. Huc, “Conformational interplay in hybrid peptide–helical aromatic foldamer macrocycles,” <i>Chemical Science</i>, vol. 12, no. 33. Royal Society of Chemistry, pp. 11004–11012, 2021.","chicago":"Dengler, Sebastian, Pradeep K Mandal, Lars Allmendinger, Céline Douat, and Ivan Huc. “Conformational Interplay in Hybrid Peptide–Helical Aromatic Foldamer Macrocycles.” <i>Chemical Science</i>. Royal Society of Chemistry, 2021. <a href=\"https://doi.org/10.1039/d1sc03640h\">https://doi.org/10.1039/d1sc03640h</a>.","ista":"Dengler S, Mandal PK, Allmendinger L, Douat C, Huc I. 2021. Conformational interplay in hybrid peptide–helical aromatic foldamer macrocycles. Chemical Science. 12(33), 11004–11012.","ama":"Dengler S, Mandal PK, Allmendinger L, Douat C, Huc I. Conformational interplay in hybrid peptide–helical aromatic foldamer macrocycles. <i>Chemical Science</i>. 2021;12(33):11004-11012. doi:<a href=\"https://doi.org/10.1039/d1sc03640h\">10.1039/d1sc03640h</a>","mla":"Dengler, Sebastian, et al. “Conformational Interplay in Hybrid Peptide–Helical Aromatic Foldamer Macrocycles.” <i>Chemical Science</i>, vol. 12, no. 33, Royal Society of Chemistry, 2021, pp. 11004–12, doi:<a href=\"https://doi.org/10.1039/d1sc03640h\">10.1039/d1sc03640h</a>.","short":"S. Dengler, P.K. Mandal, L. Allmendinger, C. Douat, I. Huc, Chemical Science 12 (2021) 11004–11012.","apa":"Dengler, S., Mandal, P. K., Allmendinger, L., Douat, C., &#38; Huc, I. (2021). Conformational interplay in hybrid peptide–helical aromatic foldamer macrocycles. <i>Chemical Science</i>. Royal Society of Chemistry. <a href=\"https://doi.org/10.1039/d1sc03640h\">https://doi.org/10.1039/d1sc03640h</a>"},"publisher":"Royal Society of Chemistry","volume":12,"doi":"10.1039/d1sc03640h","date_updated":"2026-02-20T06:57:41Z","issue":"33","ddc":["540"],"publication_identifier":{"issn":["2041-6520"],"eissn":["2041-6539"]},"title":"Conformational interplay in hybrid peptide–helical aromatic foldamer macrocycles","page":"11004-11012","fulldoi":"https://doi.org/10.1039/d1sc03640h","publication":"Chemical Science","author":[{"last_name":"Dengler","full_name":"Dengler, Sebastian","first_name":"Sebastian"},{"last_name":"Mandal","id":"6a3def15-d4b4-11ef-9fa9-a24c1f545ec3","full_name":"Mandal, Pradeep K","orcid":"0000-0001-5996-956X","first_name":"Pradeep K"},{"last_name":"Allmendinger","first_name":"Lars","full_name":"Allmendinger, Lars"},{"last_name":"Douat","first_name":"Céline","full_name":"Douat, Céline"},{"full_name":"Huc, Ivan","first_name":"Ivan","last_name":"Huc"}]},{"issue":"46","publication_identifier":{"eissn":["1364-548X"],"issn":["1359-7345"]},"page":"5662-5665","title":"Quantitative helix handedness bias through a single H vs. CH3 stereochemical differentiation","fulldoi":"https://doi.org/10.1039/d1cc01452h","author":[{"full_name":"Bindl, Daniel","first_name":"Daniel","last_name":"Bindl"},{"last_name":"Heinemann","full_name":"Heinemann, Elisabeth","first_name":"Elisabeth"},{"last_name":"Mandal","id":"6a3def15-d4b4-11ef-9fa9-a24c1f545ec3","full_name":"Mandal, Pradeep K","first_name":"Pradeep K","orcid":"0000-0001-5996-956X"},{"full_name":"Huc, Ivan","first_name":"Ivan","last_name":"Huc"}],"publication":"Chemical Communications","citation":{"short":"D. Bindl, E. Heinemann, P.K. Mandal, I. Huc, Chemical Communications 57 (2021) 5662–5665.","apa":"Bindl, D., Heinemann, E., Mandal, P. K., &#38; Huc, I. (2021). Quantitative helix handedness bias through a single H vs. CH3 stereochemical differentiation. <i>Chemical Communications</i>. Royal Society of Chemistry. <a href=\"https://doi.org/10.1039/d1cc01452h\">https://doi.org/10.1039/d1cc01452h</a>","mla":"Bindl, Daniel, et al. “Quantitative Helix Handedness Bias through a Single H vs. CH3 Stereochemical Differentiation.” <i>Chemical Communications</i>, vol. 57, no. 46, Royal Society of Chemistry, 2021, pp. 5662–65, doi:<a href=\"https://doi.org/10.1039/d1cc01452h\">10.1039/d1cc01452h</a>.","ista":"Bindl D, Heinemann E, Mandal PK, Huc I. 2021. Quantitative helix handedness bias through a single H vs. CH3 stereochemical differentiation. Chemical Communications. 57(46), 5662–5665.","ama":"Bindl D, Heinemann E, Mandal PK, Huc I. Quantitative helix handedness bias through a single H vs. CH3 stereochemical differentiation. <i>Chemical Communications</i>. 2021;57(46):5662-5665. doi:<a href=\"https://doi.org/10.1039/d1cc01452h\">10.1039/d1cc01452h</a>","chicago":"Bindl, Daniel, Elisabeth Heinemann, Pradeep K Mandal, and Ivan Huc. “Quantitative Helix Handedness Bias through a Single H vs. CH3 Stereochemical Differentiation.” <i>Chemical Communications</i>. Royal Society of Chemistry, 2021. <a href=\"https://doi.org/10.1039/d1cc01452h\">https://doi.org/10.1039/d1cc01452h</a>.","ieee":"D. Bindl, E. Heinemann, P. K. Mandal, and I. Huc, “Quantitative helix handedness bias through a single H vs. CH3 stereochemical differentiation,” <i>Chemical Communications</i>, vol. 57, no. 46. Royal Society of Chemistry, pp. 5662–5665, 2021."},"year":"2021","volume":57,"publisher":"Royal Society of Chemistry","external_id":{"pmid":["33972976 "]},"pmid":1,"date_updated":"2026-02-20T07:01:01Z","doi":"10.1039/d1cc01452h","OA_type":"closed access","intvolume":"        57","month":"04","date_created":"2026-01-29T15:18:02Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"21082","type":"journal_article","day":"29","quality_controlled":"1","article_type":"original","language":[{"iso":"eng"}],"extern":"1","oa_version":"None","article_processing_charge":"No","date_published":"2021-04-29T00:00:00Z","has_accepted_license":"1","publication_status":"published","status":"public","abstract":[{"text":"A novel chiral aromatic δ-amino acid building block was shown to fully induce handedness in quinoline oligoamide foldamers with the possibility of further increasing the bias by combining multiples of these units in the same sequence. Through its incorporation within the helix, both N- and C-termini are still accessible for further functionalisation.","lang":"eng"}]},{"page":"17366-17370","title":"Aromatic foldamer helices as α‐helix extended surface mimetics","publication":"Chemistry – A European Journal","author":[{"last_name":"Zwillinger","full_name":"Zwillinger, Márton","first_name":"Márton"},{"last_name":"Reddy","full_name":"Reddy, Post Sai","first_name":"Post Sai"},{"first_name":"Barbara","full_name":"Wicher, Barbara","last_name":"Wicher"},{"full_name":"Mandal, Pradeep K","first_name":"Pradeep K","orcid":"0000-0001-5996-956X","last_name":"Mandal","id":"6a3def15-d4b4-11ef-9fa9-a24c1f545ec3"},{"last_name":"Csékei","first_name":"Márton","full_name":"Csékei, Márton"},{"last_name":"Fischer","first_name":"Lucile","full_name":"Fischer, Lucile"},{"first_name":"András","full_name":"Kotschy, András","last_name":"Kotschy"},{"first_name":"Ivan","full_name":"Huc, Ivan","last_name":"Huc"}],"fulldoi":"https://doi.org/10.1002/chem.202004064","ddc":["540"],"issue":"72","publication_identifier":{"issn":["0947-6539"],"eissn":["1521-3765"]},"date_updated":"2026-02-20T06:53:53Z","doi":"10.1002/chem.202004064","OA_place":"publisher","publisher":"Wiley","volume":26,"citation":{"chicago":"Zwillinger, Márton, Post Sai Reddy, Barbara Wicher, Pradeep K Mandal, Márton Csékei, Lucile Fischer, András Kotschy, and Ivan Huc. “Aromatic Foldamer Helices as Α‐helix Extended Surface Mimetics.” <i>Chemistry – A European Journal</i>. Wiley, 2020. <a href=\"https://doi.org/10.1002/chem.202004064\">https://doi.org/10.1002/chem.202004064</a>.","ista":"Zwillinger M, Reddy PS, Wicher B, Mandal PK, Csékei M, Fischer L, Kotschy A, Huc I. 2020. Aromatic foldamer helices as α‐helix extended surface mimetics. Chemistry – A European Journal. 26(72), 17366–17370.","ama":"Zwillinger M, Reddy PS, Wicher B, et al. Aromatic foldamer helices as α‐helix extended surface mimetics. <i>Chemistry – A European Journal</i>. 2020;26(72):17366-17370. doi:<a href=\"https://doi.org/10.1002/chem.202004064\">10.1002/chem.202004064</a>","ieee":"M. Zwillinger <i>et al.</i>, “Aromatic foldamer helices as α‐helix extended surface mimetics,” <i>Chemistry – A European Journal</i>, vol. 26, no. 72. Wiley, pp. 17366–17370, 2020.","mla":"Zwillinger, Márton, et al. “Aromatic Foldamer Helices as Α‐helix Extended Surface Mimetics.” <i>Chemistry – A European Journal</i>, vol. 26, no. 72, Wiley, 2020, pp. 17366–70, doi:<a href=\"https://doi.org/10.1002/chem.202004064\">10.1002/chem.202004064</a>.","apa":"Zwillinger, M., Reddy, P. S., Wicher, B., Mandal, P. K., Csékei, M., Fischer, L., … Huc, I. (2020). Aromatic foldamer helices as α‐helix extended surface mimetics. <i>Chemistry – A European Journal</i>. Wiley. <a href=\"https://doi.org/10.1002/chem.202004064\">https://doi.org/10.1002/chem.202004064</a>","short":"M. Zwillinger, P.S. Reddy, B. Wicher, P.K. Mandal, M. Csékei, L. Fischer, A. Kotschy, I. Huc, Chemistry – A European Journal 26 (2020) 17366–17370."},"year":"2020","quality_controlled":"1","_id":"21083","type":"journal_article","day":"10","oa":1,"tmp":{"short":"CC BY-NC (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","image":"/images/cc_by_nc.png"},"OA_type":"hybrid","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2026-01-29T15:31:13Z","intvolume":"        26","main_file_link":[{"url":"https://doi.org/10.1002/chem.202004064","open_access":"1"}],"month":"09","oa_version":"Published Version","extern":"1","date_published":"2020-09-10T00:00:00Z","status":"public","has_accepted_license":"1","abstract":[{"lang":"eng","text":"Helically folded aromatic oligoamide foldamers have a size and geometrical parameters very distinct from those of α‐helices and are not obvious candidates for α‐helix mimicry. Nevertheless, they offer multiple sites for attaching side chains. It was found that some arrays of side chains at the surface of an aromatic helix make it possible to mimic extended α‐helical surfaces. Synthetic methods were developed to produce quinoline monomers suitably functionalized for solid phase synthesis. A dodecamer was prepared. Its crystal structure validated the initial design and showed helix bundling involving the α‐helix‐like interface. These results open up new uses of aromatic helices to recognize protein surfaces and to program helix bundling in water."}],"publication_status":"published","article_processing_charge":"No","language":[{"iso":"eng"}],"article_type":"original"},{"oa":1,"_id":"21084","type":"journal_article","day":"20","quality_controlled":"1","main_file_link":[{"open_access":"1","url":"https://doi.org/10.26434/chemrxiv.10079186"}],"month":"11","intvolume":"        12","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2026-01-29T15:32:38Z","OA_type":"green","article_processing_charge":"No","has_accepted_license":"1","status":"public","publication_status":"published","abstract":[{"lang":"eng","text":"Self-assembly is a powerful method to obtain large discrete functional molecular architectures. When using a single building block, self-assembly generally yields symmetrical objects in which all the subunits relate similarly to their neighbours. Here we report the discovery of a family of self-constructing cyclic macromolecules with stable folded conformations of low symmetry, which include some with a prime number (13, 17 and 23) of units, despite being formed from a single component. The formation of these objects amounts to the production of polymers with a perfectly uniform length. Design rules for the spontaneous emergence of such macromolecules include endowing monomers with a strong potential for non-covalent interactions that remain frustrated in competing entropically favoured yet conformationally restrained smaller cycles. The process can also be templated by a guest molecule that itself has an asymmetrical structure, which paves the way to molecular imprinting techniques at the level of single polymer chains."}],"date_published":"2020-11-20T00:00:00Z","extern":"1","oa_version":"Preprint","language":[{"iso":"eng"}],"article_type":"original","fulldoi":"https://doi.org/10.1038/s41557-020-00565-2","author":[{"full_name":"Pappas, Charalampos G.","first_name":"Charalampos G.","last_name":"Pappas"},{"last_name":"Mandal","id":"6a3def15-d4b4-11ef-9fa9-a24c1f545ec3","full_name":"Mandal, Pradeep K","orcid":"0000-0001-5996-956X","first_name":"Pradeep K"},{"full_name":"Liu, Bin","first_name":"Bin","last_name":"Liu"},{"last_name":"Kauffmann","full_name":"Kauffmann, Brice","first_name":"Brice"},{"full_name":"Miao, Xiaoming","first_name":"Xiaoming","last_name":"Miao"},{"first_name":"Dávid","full_name":"Komáromy, Dávid","last_name":"Komáromy"},{"last_name":"Hoffmann","full_name":"Hoffmann, Waldemar","first_name":"Waldemar"},{"last_name":"Manz","full_name":"Manz, Christian","first_name":"Christian"},{"full_name":"Chang, Rayoon","first_name":"Rayoon","last_name":"Chang"},{"last_name":"Liu","full_name":"Liu, Kai","first_name":"Kai"},{"first_name":"Kevin","full_name":"Pagel, Kevin","last_name":"Pagel"},{"full_name":"Huc, Ivan","first_name":"Ivan","last_name":"Huc"},{"last_name":"Otto","first_name":"Sijbren","full_name":"Otto, Sijbren"}],"publication":"Nature Chemistry","title":"Emergence of low-symmetry foldamers from single monomers","page":"1180-1186","publication_identifier":{"issn":["1755-4330"],"eissn":["1755-4349"]},"issue":"12","doi":"10.1038/s41557-020-00565-2","date_updated":"2026-02-23T11:46:11Z","pmid":1,"external_id":{"pmid":["33219361 "]},"year":"2020","citation":{"short":"C.G. Pappas, P.K. Mandal, B. Liu, B. Kauffmann, X. Miao, D. Komáromy, W. Hoffmann, C. Manz, R. Chang, K. Liu, K. Pagel, I. Huc, S. Otto, Nature Chemistry 12 (2020) 1180–1186.","apa":"Pappas, C. G., Mandal, P. K., Liu, B., Kauffmann, B., Miao, X., Komáromy, D., … Otto, S. (2020). Emergence of low-symmetry foldamers from single monomers. <i>Nature Chemistry</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41557-020-00565-2\">https://doi.org/10.1038/s41557-020-00565-2</a>","mla":"Pappas, Charalampos G., et al. “Emergence of Low-Symmetry Foldamers from Single Monomers.” <i>Nature Chemistry</i>, vol. 12, no. 12, Springer Nature, 2020, pp. 1180–86, doi:<a href=\"https://doi.org/10.1038/s41557-020-00565-2\">10.1038/s41557-020-00565-2</a>.","ieee":"C. G. Pappas <i>et al.</i>, “Emergence of low-symmetry foldamers from single monomers,” <i>Nature Chemistry</i>, vol. 12, no. 12. Springer Nature, pp. 1180–1186, 2020.","ista":"Pappas CG, Mandal PK, Liu B, Kauffmann B, Miao X, Komáromy D, Hoffmann W, Manz C, Chang R, Liu K, Pagel K, Huc I, Otto S. 2020. Emergence of low-symmetry foldamers from single monomers. Nature Chemistry. 12(12), 1180–1186.","ama":"Pappas CG, Mandal PK, Liu B, et al. Emergence of low-symmetry foldamers from single monomers. <i>Nature Chemistry</i>. 2020;12(12):1180-1186. doi:<a href=\"https://doi.org/10.1038/s41557-020-00565-2\">10.1038/s41557-020-00565-2</a>","chicago":"Pappas, Charalampos G., Pradeep K Mandal, Bin Liu, Brice Kauffmann, Xiaoming Miao, Dávid Komáromy, Waldemar Hoffmann, et al. “Emergence of Low-Symmetry Foldamers from Single Monomers.” <i>Nature Chemistry</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41557-020-00565-2\">https://doi.org/10.1038/s41557-020-00565-2</a>."},"volume":12,"publisher":"Springer Nature","OA_place":"repository"},{"oa":1,"quality_controlled":"1","type":"journal_article","_id":"21085","day":"06","date_created":"2026-01-29T15:34:50Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","intvolume":"        85","month":"07","main_file_link":[{"url":"https://doi.org/10.1002/cplu.202000416","open_access":"1"}],"tmp":{"short":"CC BY-NC (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","image":"/images/cc_by_nc.png"},"OA_type":"hybrid","date_published":"2020-07-06T00:00:00Z","publication_status":"published","has_accepted_license":"1","abstract":[{"lang":"eng","text":"Foldamers combining aliphatic and aromatic main-chain units often produce atypical structures that cannot easily be accessed from purely aromatic or aliphatic sequences. We report solid-state evidence that sequences comprising α-amino acids and quinoline-based monomers adopt conformations that combine the folding propensities of both components. Foldamers 2 and 3 having an XQQ repeat motif (X=α-amino acid, Q=quinoline) were synthesized. Crystals of 2 (X=Phe, Q with an anionic side chain) obtained from water revealed an aromatic helix where amide groups belonging to the α-amino acids created a hydrogen-bond array typical of peptidic helices. Crystals of 3 (X=Ser, Q with a lipophilic side chain) obtained from organic solvents revealed a helix-turn-helix structure in which α-amino acid side chains interfere with main-chain hydrogen bonding. High sequence-dependency of the conformation is typical of peptides but is shown here to include aromatic folding features."}],"status":"public","article_processing_charge":"No","oa_version":"Published Version","extern":"1","language":[{"iso":"eng"}],"article_type":"original","author":[{"first_name":"Xiaobo","full_name":"Hu, Xiaobo","last_name":"Hu"},{"last_name":"Mandal","id":"6a3def15-d4b4-11ef-9fa9-a24c1f545ec3","full_name":"Mandal, Pradeep K","first_name":"Pradeep K","orcid":"0000-0001-5996-956X"},{"full_name":"Kauffmann, Brice","first_name":"Brice","last_name":"Kauffmann"},{"last_name":"Huc","first_name":"Ivan","full_name":"Huc, Ivan"}],"publication":"ChemPlusChem","fulldoi":"https://doi.org/10.1002/cplu.202000416","page":"1580-1586","title":"Hybrid sequences that express both aromatic amide and α‐peptidic folding features","publication_identifier":{"eissn":["2192-6506"]},"issue":"7","scopus_import":"1","external_id":{"pmid":["32729681"]},"pmid":1,"doi":"10.1002/cplu.202000416","date_updated":"2026-02-20T06:51:31Z","publisher":"Wiley","volume":85,"citation":{"apa":"Hu, X., Mandal, P. K., Kauffmann, B., &#38; Huc, I. (2020). Hybrid sequences that express both aromatic amide and α‐peptidic folding features. <i>ChemPlusChem</i>. Wiley. <a href=\"https://doi.org/10.1002/cplu.202000416\">https://doi.org/10.1002/cplu.202000416</a>","short":"X. Hu, P.K. Mandal, B. Kauffmann, I. Huc, ChemPlusChem 85 (2020) 1580–1586.","mla":"Hu, Xiaobo, et al. “Hybrid Sequences That Express Both Aromatic Amide and Α‐peptidic Folding Features.” <i>ChemPlusChem</i>, vol. 85, no. 7, Wiley, 2020, pp. 1580–86, doi:<a href=\"https://doi.org/10.1002/cplu.202000416\">10.1002/cplu.202000416</a>.","ama":"Hu X, Mandal PK, Kauffmann B, Huc I. Hybrid sequences that express both aromatic amide and α‐peptidic folding features. <i>ChemPlusChem</i>. 2020;85(7):1580-1586. doi:<a href=\"https://doi.org/10.1002/cplu.202000416\">10.1002/cplu.202000416</a>","ista":"Hu X, Mandal PK, Kauffmann B, Huc I. 2020. Hybrid sequences that express both aromatic amide and α‐peptidic folding features. ChemPlusChem. 85(7), 1580–1586.","chicago":"Hu, Xiaobo, Pradeep K Mandal, Brice Kauffmann, and Ivan Huc. “Hybrid Sequences That Express Both Aromatic Amide and Α‐peptidic Folding Features.” <i>ChemPlusChem</i>. Wiley, 2020. <a href=\"https://doi.org/10.1002/cplu.202000416\">https://doi.org/10.1002/cplu.202000416</a>.","ieee":"X. Hu, P. K. Mandal, B. Kauffmann, and I. Huc, “Hybrid sequences that express both aromatic amide and α‐peptidic folding features,” <i>ChemPlusChem</i>, vol. 85, no. 7. Wiley, pp. 1580–1586, 2020."},"year":"2020","OA_place":"publisher"},{"extern":"1","oa_version":"Published Version","article_processing_charge":"No","abstract":[{"lang":"eng","text":"Inspired by DNA mimic proteins, we have introduced aromatic foldamers bearing phosphonate groups as synthetic mimics of the charge surface of B-DNA and competitive inhibitors of some therapeutically relevant DNA-binding enzymes: the human DNA Topoisomerase 1 (Top1) and the human HIV-1 integrase (HIV-1 IN). We now report on variants of these anionic foldamers bearing carboxylates instead of phosphonates. Several new monomers have been synthesized with protecting groups suitable for solid phase synthesis (SPS). Six hexadecaamides have been prepared using SPS. Proof of their resemblance to B-DNA was brought by the first crystal structure of one of these DNA-mimic foldamers in its polyanionic form. While some of the foldamers were found to be as active as, or even more active than, the original phosphonate oligomers, others had no activity at all or could even stimulate enzyme activity in vitro. Some foldamers were found to have differential inhibitory effects on the two enzymes. These results demonstrate a strong dependence of inhibitory activity on foldamer structure and charge distribution. They open broad avenues for the development of new classes of derivatives that could inhibit the interaction of specific proteins with their DNA target thereby influencing the cellular pathways in which they are involved."}],"publication_status":"published","status":"public","has_accepted_license":"1","date_published":"2019-06-20T00:00:00Z","article_type":"original","language":[{"iso":"eng"}],"_id":"21095","day":"20","type":"journal_article","quality_controlled":"1","oa":1,"DOAJ_listed":"1","OA_type":"gold","tmp":{"short":"CC BY-NC (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","image":"/images/cc_by_nc.png"},"month":"06","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1093/nar/gkz352"}],"intvolume":"        47","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2026-01-29T21:17:15Z","doi":"10.1093/nar/gkz352","date_updated":"2026-02-23T09:56:28Z","OA_place":"publisher","citation":{"mla":"Corvaglia, Valentina, et al. “Carboxylate-Functionalized Foldamer Inhibitors of HIV-1 Integrase and Topoisomerase 1: Artificial Analogues of DNA Mimic Proteins.” <i>Nucleic Acids Research</i>, vol. 47, no. 11, Oxford University Press, 2019, pp. 5511–21, doi:<a href=\"https://doi.org/10.1093/nar/gkz352\">10.1093/nar/gkz352</a>.","short":"V. Corvaglia, D. Carbajo, P. Prabhakaran, K. Ziach, P.K. Mandal, V.D. Santos, C. Legeay, R. Vogel, V. Parissi, P. Pourquier, I. Huc, Nucleic Acids Research 47 (2019) 5511–5521.","apa":"Corvaglia, V., Carbajo, D., Prabhakaran, P., Ziach, K., Mandal, P. K., Santos, V. D., … Huc, I. (2019). Carboxylate-functionalized foldamer inhibitors of HIV-1 integrase and Topoisomerase 1: Artificial analogues of DNA mimic proteins. <i>Nucleic Acids Research</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/nar/gkz352\">https://doi.org/10.1093/nar/gkz352</a>","chicago":"Corvaglia, Valentina, Daniel Carbajo, Panchami Prabhakaran, Krzysztof Ziach, Pradeep K Mandal, Victor Dos Santos, Carole Legeay, et al. “Carboxylate-Functionalized Foldamer Inhibitors of HIV-1 Integrase and Topoisomerase 1: Artificial Analogues of DNA Mimic Proteins.” <i>Nucleic Acids Research</i>. Oxford University Press, 2019. <a href=\"https://doi.org/10.1093/nar/gkz352\">https://doi.org/10.1093/nar/gkz352</a>.","ama":"Corvaglia V, Carbajo D, Prabhakaran P, et al. Carboxylate-functionalized foldamer inhibitors of HIV-1 integrase and Topoisomerase 1: Artificial analogues of DNA mimic proteins. <i>Nucleic Acids Research</i>. 2019;47(11):5511-5521. doi:<a href=\"https://doi.org/10.1093/nar/gkz352\">10.1093/nar/gkz352</a>","ista":"Corvaglia V, Carbajo D, Prabhakaran P, Ziach K, Mandal PK, Santos VD, Legeay C, Vogel R, Parissi V, Pourquier P, Huc I. 2019. Carboxylate-functionalized foldamer inhibitors of HIV-1 integrase and Topoisomerase 1: Artificial analogues of DNA mimic proteins. Nucleic Acids Research. 47(11), 5511–5521.","ieee":"V. Corvaglia <i>et al.</i>, “Carboxylate-functionalized foldamer inhibitors of HIV-1 integrase and Topoisomerase 1: Artificial analogues of DNA mimic proteins,” <i>Nucleic Acids Research</i>, vol. 47, no. 11. Oxford University Press, pp. 5511–5521, 2019."},"year":"2019","publisher":"Oxford University Press","volume":47,"title":"Carboxylate-functionalized foldamer inhibitors of HIV-1 integrase and Topoisomerase 1: Artificial analogues of DNA mimic proteins","page":"5511-5521","fulldoi":"https://doi.org/10.1093/nar/gkz352","author":[{"last_name":"Corvaglia","full_name":"Corvaglia, Valentina","first_name":"Valentina"},{"last_name":"Carbajo","first_name":"Daniel","full_name":"Carbajo, Daniel"},{"last_name":"Prabhakaran","full_name":"Prabhakaran, Panchami","first_name":"Panchami"},{"full_name":"Ziach, Krzysztof","first_name":"Krzysztof","last_name":"Ziach"},{"last_name":"Mandal","id":"6a3def15-d4b4-11ef-9fa9-a24c1f545ec3","full_name":"Mandal, Pradeep K","orcid":"0000-0001-5996-956X","first_name":"Pradeep K"},{"last_name":"Santos","first_name":"Victor Dos","full_name":"Santos, Victor Dos"},{"full_name":"Legeay, Carole","first_name":"Carole","last_name":"Legeay"},{"full_name":"Vogel, Rachel","first_name":"Rachel","last_name":"Vogel"},{"last_name":"Parissi","first_name":"Vincent","full_name":"Parissi, Vincent"},{"full_name":"Pourquier, Philippe","first_name":"Philippe","last_name":"Pourquier"},{"first_name":"Ivan","full_name":"Huc, Ivan","last_name":"Huc"}],"publication":"Nucleic Acids Research","issue":"11","publication_identifier":{"eissn":["1362-4962"],"issn":["0305-1048"]}},{"oa_version":"None","extern":"1","date_published":"2018-12-27T00:00:00Z","has_accepted_license":"1","status":"public","abstract":[{"lang":"eng","text":"The X-ray crystal structures of a decamer sequence d(CGCGTACGCG)2 and a tetradecamer sequence d(CGCGCGTACGCGCG)2 are presented here. Both sequences are alternating pyrimidine-purine repeat sequences and they form disordered, pseudo-continuous left handed Z-type helices. They demonstrate interesting variants of the ‘bundles of columns of helices’ mode of packing."}],"publication_status":"published","article_processing_charge":"No","language":[{"iso":"eng"}],"article_type":"original","quality_controlled":"1","type":"journal_article","_id":"21094","day":"27","OA_type":"closed access","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2026-01-29T21:15:08Z","intvolume":"        38","month":"12","external_id":{"pmid":["30588873"]},"pmid":1,"date_updated":"2026-02-20T08:27:39Z","doi":"10.1080/15257770.2018.1517883","volume":38,"publisher":"Informa UK Limited","year":"2018","citation":{"ieee":"S. Karthik, P. K. Mandal, A. Thirugnanasambandam, and N. Gautham, “Crystal structures of disordered Z-type helices,” <i>Nucleosides, Nucleotides &#38;amp; Nucleic Acids</i>, vol. 38, no. 4. Informa UK Limited, pp. 279–293, 2018.","chicago":"Karthik, S., Pradeep K Mandal, A. Thirugnanasambandam, and N. Gautham. “Crystal Structures of Disordered Z-Type Helices.” <i>Nucleosides, Nucleotides &#38;amp; Nucleic Acids</i>. Informa UK Limited, 2018. <a href=\"https://doi.org/10.1080/15257770.2018.1517883\">https://doi.org/10.1080/15257770.2018.1517883</a>.","ista":"Karthik S, Mandal PK, Thirugnanasambandam A, Gautham N. 2018. Crystal structures of disordered Z-type helices. Nucleosides, Nucleotides &#38;amp; Nucleic Acids. 38(4), 279–293.","ama":"Karthik S, Mandal PK, Thirugnanasambandam A, Gautham N. Crystal structures of disordered Z-type helices. <i>Nucleosides, Nucleotides &#38;amp; Nucleic Acids</i>. 2018;38(4):279-293. doi:<a href=\"https://doi.org/10.1080/15257770.2018.1517883\">10.1080/15257770.2018.1517883</a>","mla":"Karthik, S., et al. “Crystal Structures of Disordered Z-Type Helices.” <i>Nucleosides, Nucleotides &#38;amp; Nucleic Acids</i>, vol. 38, no. 4, Informa UK Limited, 2018, pp. 279–93, doi:<a href=\"https://doi.org/10.1080/15257770.2018.1517883\">10.1080/15257770.2018.1517883</a>.","short":"S. Karthik, P.K. Mandal, A. Thirugnanasambandam, N. Gautham, Nucleosides, Nucleotides &#38;amp; Nucleic Acids 38 (2018) 279–293.","apa":"Karthik, S., Mandal, P. K., Thirugnanasambandam, A., &#38; Gautham, N. (2018). Crystal structures of disordered Z-type helices. <i>Nucleosides, Nucleotides &#38;amp; Nucleic Acids</i>. Informa UK Limited. <a href=\"https://doi.org/10.1080/15257770.2018.1517883\">https://doi.org/10.1080/15257770.2018.1517883</a>"},"page":"279-293","title":"Crystal structures of disordered Z-type helices","author":[{"last_name":"Karthik","first_name":"S.","full_name":"Karthik, S."},{"id":"6a3def15-d4b4-11ef-9fa9-a24c1f545ec3","last_name":"Mandal","full_name":"Mandal, Pradeep K","orcid":"0000-0001-5996-956X","first_name":"Pradeep K"},{"full_name":"Thirugnanasambandam, A.","first_name":"A.","last_name":"Thirugnanasambandam"},{"first_name":"N.","full_name":"Gautham, N.","last_name":"Gautham"}],"publication":"Nucleosides, Nucleotides &amp; Nucleic Acids","fulldoi":"https://doi.org/10.1080/15257770.2018.1517883","issue":"4","publication_identifier":{"issn":["1525-7770"],"eissn":["1532-2335"]}}]