---
OA_place: publisher
_id: '20117'
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
- _id: PreCl
acknowledgement: "I would also like to acknowledge the invaluable assistance provided
  by the Plant\r\nFacility, Imaging & Optics Facility, and the Lab Support Facility.
  The technical support and\r\nresources offered by these facilities were indispensable
  to the successful completion of my\r\nexperiments."
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Yiqun
  full_name: Wang, Yiqun
  id: 82F537F2-B517-11E9-84D7-6433E6697425
  last_name: Wang
citation:
  ama: Wang Y. The role of dynamin related protein 2A in cytokinin regulated plant
    growth and development. 2025. doi:<a href="https://doi.org/10.15479/AT-ISTA-20117">10.15479/AT-ISTA-20117</a>
  apa: Wang, Y. (2025). <i>The role of dynamin related protein 2A in cytokinin regulated
    plant growth and development</i>. Institute of Science and Technology Austria.
    <a href="https://doi.org/10.15479/AT-ISTA-20117">https://doi.org/10.15479/AT-ISTA-20117</a>
  chicago: Wang, Yiqun. “The Role of Dynamin Related Protein 2A in Cytokinin Regulated
    Plant Growth and Development.” Institute of Science and Technology Austria, 2025.
    <a href="https://doi.org/10.15479/AT-ISTA-20117">https://doi.org/10.15479/AT-ISTA-20117</a>.
  ieee: Y. Wang, “The role of dynamin related protein 2A in cytokinin regulated plant
    growth and development,” Institute of Science and Technology Austria, 2025.
  ista: Wang Y. 2025. The role of dynamin related protein 2A in cytokinin regulated
    plant growth and development. Institute of Science and Technology Austria.
  mla: Wang, Yiqun. <i>The Role of Dynamin Related Protein 2A in Cytokinin Regulated
    Plant Growth and Development</i>. Institute of Science and Technology Austria,
    2025, doi:<a href="https://doi.org/10.15479/AT-ISTA-20117">10.15479/AT-ISTA-20117</a>.
  short: Y. Wang, The Role of Dynamin Related Protein 2A in Cytokinin Regulated Plant
    Growth and Development, Institute of Science and Technology Austria, 2025.
corr_author: '1'
date_created: 2025-08-04T15:24:21Z
date_published: 2025-08-04T00:00:00Z
date_updated: 2026-04-07T11:49:34Z
day: '04'
ddc:
- '580'
degree_awarded: PhD
department:
- _id: GradSch
- _id: EvBe
doi: 10.15479/AT-ISTA-20117
file:
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  creator: yiqwang
  date_created: 2025-08-22T08:22:10Z
  date_updated: 2025-08-22T08:53:46Z
  file_id: '20209'
  file_name: 2025_Wang_Yiqun_Thesis.docx
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  creator: yiqwang
  date_created: 2025-08-22T10:32:30Z
  date_updated: 2025-09-03T09:36:52Z
  embargo: 2026-09-03
  embargo_to: open_access
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  file_name: 2025_Wang_Yiqun_Thesis.pdf
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file_date_updated: 2025-09-03T09:36:52Z
has_accepted_license: '1'
language:
- iso: eng
month: '08'
oa_version: Published Version
page: '108'
publication_identifier:
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '18063'
    relation: part_of_dissertation
    status: public
status: public
supervisor:
- first_name: Eva
  full_name: Benková, Eva
  id: 38F4F166-F248-11E8-B48F-1D18A9856A87
  last_name: Benková
  orcid: 0000-0002-8510-9739
title: The role of dynamin related protein 2A in cytokinin regulated plant growth
  and development
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2025'
...
---
_id: '18063'
abstract:
- lang: eng
  text: The developmental plasticity of the root system plays an essential role in
    the adaptation of plants to the environment. Among many other signals, auxin and
    its directional, intercellular transport are critical in regulating root growth
    and development. In particular, the PIN-FORMED2 (PIN2) auxin exporter acts as
    a key regulator of root gravitropic growth. Multiple regulators have been reported
    to be involved in PIN2-mediated root growth; however, our information remains
    incomplete. Here, we identified ROWY Bro1-domain proteins as important regulators
    of PIN2 sorting control. Genetic analysis revealed that Arabidopsis rowy1 single
    mutants and higher-order rowy1 rowy2 rowy3 triple mutants presented a wavy root
    growth phenotype. Cell biological experiments revealed that ROWY1 and PIN2 colocalized
    to the apical side of the plasma membrane in the root epidermis and that ROWYs
    are required for correct PM targeting of PIN2. In addition, ROWYs also affected
    PIN3 protein abundance in the stele, suggesting the potential involvement of additional
    PIN transporters as well as other proteins. A global transcriptome analysis revealed
    that ROWY genes are involved in the Fe2+ availability perception pathway. This
    work establishes ROWYs as important novel regulators of root gravitropic growth
    by connecting micronutrient availability to the proper subcellular targeting of
    PIN auxin transporters.
acknowledgement: We thank Drs. Erika Isono (University of Constance), Grégory Vert
  (University of Toulouse), and Liwen Jiang (The Chinese University of Hong Kong)
  for kindly sharing published Arabidopsis lines; Dr. Yuzhou Zhang (ISTA) for help
  with molecular cloning, and Drs. Melinda Abas (BOKU), Eugenia Russinova (Ghent University),
  and Zhaojun Ding (Shandong University) for valuable discussions. This work was supported
  by grants to S.T. from the National Natural Science Foundation of China (32321001),
  the USTC Research Funds of the Double First-Class Initiative (YD9100002016), the
  Research Funds from the Center for Advanced Interdisciplinary Science and Biomedicine
  of IHM, the Division of Life Sciences and Medicine, the University of Science and
  Technology of China (QYPY20220012), the Fundamental Research Funds for the Central
  Universities (WK9100000021), and start-up funding from the University of Science
  and Technology of China and the Chinese Academy of Sciences (GG9100007007, KY9100000026,
  KY9100000051, and KJ2070000079). J.S. was supported by the National Natural Science
  Foundation of China (31970181 and 32170342). J.F. was supported by Austrian Science
  Fund (FWF; projects I6123 and P37051-B).
article_number: '1085'
article_processing_charge: Yes
article_type: original
author:
- first_name: Yakun
  full_name: Peng, Yakun
  last_name: Peng
- first_name: Kangkang
  full_name: Ji, Kangkang
  last_name: Ji
- first_name: Yanbo
  full_name: Mao, Yanbo
  last_name: Mao
- first_name: Yiqun
  full_name: Wang, Yiqun
  id: 82F537F2-B517-11E9-84D7-6433E6697425
  last_name: Wang
- first_name: Barbara
  full_name: Korbei, Barbara
  last_name: Korbei
- first_name: Christian
  full_name: Luschnig, Christian
  last_name: Luschnig
- first_name: Jinbo
  full_name: Shen, Jinbo
  last_name: Shen
- first_name: Eva
  full_name: Benková, Eva
  id: 38F4F166-F248-11E8-B48F-1D18A9856A87
  last_name: Benková
  orcid: 0000-0002-8510-9739
- first_name: Jiří
  full_name: Friml, Jiří
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
- first_name: Shutang
  full_name: Tan, Shutang
  id: 2DE75584-F248-11E8-B48F-1D18A9856A87
  last_name: Tan
  orcid: 0000-0002-0471-8285
citation:
  ama: Peng Y, Ji K, Mao Y, et al. Polarly localized Bro1 domain proteins regulate
    PIN-FORMED abundance and root gravitropic growth in Arabidopsis. <i>Communications
    Biology</i>. 2024;7. doi:<a href="https://doi.org/10.1038/s42003-024-06747-9">10.1038/s42003-024-06747-9</a>
  apa: Peng, Y., Ji, K., Mao, Y., Wang, Y., Korbei, B., Luschnig, C., … Tan, S. (2024).
    Polarly localized Bro1 domain proteins regulate PIN-FORMED abundance and root
    gravitropic growth in Arabidopsis. <i>Communications Biology</i>. Springer Nature.
    <a href="https://doi.org/10.1038/s42003-024-06747-9">https://doi.org/10.1038/s42003-024-06747-9</a>
  chicago: Peng, Yakun, Kangkang Ji, Yanbo Mao, Yiqun Wang, Barbara Korbei, Christian
    Luschnig, Jinbo Shen, Eva Benková, Jiří Friml, and Shutang Tan. “Polarly Localized
    Bro1 Domain Proteins Regulate PIN-FORMED Abundance and Root Gravitropic Growth
    in Arabidopsis.” <i>Communications Biology</i>. Springer Nature, 2024. <a href="https://doi.org/10.1038/s42003-024-06747-9">https://doi.org/10.1038/s42003-024-06747-9</a>.
  ieee: Y. Peng <i>et al.</i>, “Polarly localized Bro1 domain proteins regulate PIN-FORMED
    abundance and root gravitropic growth in Arabidopsis,” <i>Communications Biology</i>,
    vol. 7. Springer Nature, 2024.
  ista: Peng Y, Ji K, Mao Y, Wang Y, Korbei B, Luschnig C, Shen J, Benková E, Friml
    J, Tan S. 2024. Polarly localized Bro1 domain proteins regulate PIN-FORMED abundance
    and root gravitropic growth in Arabidopsis. Communications Biology. 7, 1085.
  mla: Peng, Yakun, et al. “Polarly Localized Bro1 Domain Proteins Regulate PIN-FORMED
    Abundance and Root Gravitropic Growth in Arabidopsis.” <i>Communications Biology</i>,
    vol. 7, 1085, Springer Nature, 2024, doi:<a href="https://doi.org/10.1038/s42003-024-06747-9">10.1038/s42003-024-06747-9</a>.
  short: Y. Peng, K. Ji, Y. Mao, Y. Wang, B. Korbei, C. Luschnig, J. Shen, E. Benková,
    J. Friml, S. Tan, Communications Biology 7 (2024).
date_created: 2024-09-15T22:01:38Z
date_published: 2024-09-04T00:00:00Z
date_updated: 2026-04-07T11:49:33Z
day: '04'
ddc:
- '570'
department:
- _id: EvBe
- _id: JiFr
doi: 10.1038/s42003-024-06747-9
external_id:
  isi:
  - '001306499600002'
  pmid:
  - '39232040'
file:
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  creator: dernst
  date_created: 2024-09-17T09:44:29Z
  date_updated: 2024-09-17T09:44:29Z
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  relation: main_file
  success: 1
file_date_updated: 2024-09-17T09:44:29Z
has_accepted_license: '1'
intvolume: '         7'
isi: 1
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: bd76d395-d553-11ed-ba76-f678c14f9033
  grant_number: I06123
  name: Peptide receptors for auxin canalization in Arabidopsis
- _id: 7bcece63-9f16-11ee-852c-ae94e099eeb6
  grant_number: P37051
  name: Guanylate cyclase activity of TIR1/AFBs auxin receptors
publication: Communications Biology
publication_identifier:
  eissn:
  - 2399-3642
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
  record:
  - id: '20117'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: Polarly localized Bro1 domain proteins regulate PIN-FORMED abundance and root
  gravitropic growth in Arabidopsis
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 7
year: '2024'
...