[{"DOAJ_listed":"1","ec_funded":1,"project":[{"_id":"eba2549b-77a9-11ec-83b8-a81e493eae4e","call_identifier":"H2020","grant_number":"802960","name":"Non-Equilibrium Protein Assembly: from Building Blocks to Biological Machines"},{"_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","call_identifier":"H2020","name":"IST-BRIDGE: International postdoctoral program","grant_number":"101034413"},{"name":"EMBO Young Investigator Program - Andela Saric","_id":"349b6ff1-11ca-11ed-8bc3-f006047c2eeb"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"AnSa"},{"_id":"EdHa"}],"title":"Charge distribution of the coating brush drives interchromosome attraction","article_type":"original","oa_version":"Published Version","PlanS_conform":"1","type":"journal_article","file":[{"creator":"dernst","file_id":"21287","relation":"main_file","file_size":3732843,"checksum":"1702b9bdbfd902a7c08aa4f1479b390d","file_name":"2025_PRXLife_Sorichetti.pdf","date_updated":"2026-02-17T11:12:30Z","access_level":"open_access","date_created":"2026-02-17T11:12:30Z","content_type":"application/pdf","success":1}],"_id":"21235","ddc":["570"],"language":[{"iso":"eng"}],"OA_type":"gold","article_processing_charge":"Yes","date_updated":"2026-02-17T11:16:26Z","publication_status":"published","issue":"3","status":"public","doi":"10.1103/41fd-r847","intvolume":"         3","license":"https://creativecommons.org/licenses/by/4.0/","oa":1,"author":[{"first_name":"Valerio","last_name":"Sorichetti","orcid":"0000-0002-9645-6576","id":"ef8a92cb-c7b6-11ec-8bea-e1fd5847bc5b","full_name":"Sorichetti, Valerio"},{"full_name":"Robin, Paul","last_name":"Robin","first_name":"Paul","id":"48c58128-57b0-11ee-9095-dc28fd97fc1d","orcid":"0000-0002-5728-9189"},{"full_name":"Palaia, Ivan","id":"9c805cd2-4b75-11ec-a374-db6dd0ed57fa","orcid":" 0000-0002-8843-9485 ","last_name":"Palaia","first_name":"Ivan"},{"last_name":"Hernandez-Armendariz","first_name":"Alberto","full_name":"Hernandez-Armendariz, Alberto"},{"first_name":"Sara","last_name":"Cuylen-Haering","full_name":"Cuylen-Haering, Sara"},{"full_name":"Šarić, Anđela","last_name":"Šarić","first_name":"Anđela","id":"bf63d406-f056-11eb-b41d-f263a6566d8b","orcid":"0000-0002-7854-2139"}],"quality_controlled":"1","month":"08","volume":3,"year":"2025","day":"11","article_number":"033010","date_created":"2026-02-16T14:50:32Z","publication_identifier":{"eissn":["2835-8279"]},"OA_place":"publisher","file_date_updated":"2026-02-17T11:12:30Z","acknowledgement":"This work was supported by the European Union’s Horizon 2020 research and innovation programme (A.Š. and V.S., ERC grant Agreement No. 802960 to A.Š., I.P. and P.R.,\r\nMarie Skłodowska-Curie Grant Agreement No. 101034413), the German Research Foundation (S.C-H. and A.H.-A., DFG Project No. 402723784 to S.C-H.), the Vallee Scholarship\r\n(A.Š. and V.S.), the EMBO Young Investigator Programme (A.Š.), and a Ph.D. fellowship from the Boehringer Ingelheim Fonds (A.H.-A.).","date_published":"2025-08-11T00:00:00Z","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"publisher":"American Physical Society","has_accepted_license":"1","corr_author":"1","abstract":[{"text":"The condensation of charged polymers is an important driver for the formation of biomolecular condensates. Recent experiments suggest that this mechanism also controls the clustering of eukaryotic chromosomes during the late stages of cell division. In this process, interchromosome attraction is driven by the condensation of cytoplasmic RNA and Ki-67, a charged intrinsically disordered protein that coats the chromosomes as a brush. Attraction between chromosomes has been shown to be specifically promoted by a localized charged patch on Ki-67, although the physical mechanism remains unclear. To elucidate this process, we combine coarse-grained simulations and analytical theory to study the RNA-mediated interaction between charged polymer brushes on the chromosome surfaces. We show that the charged patch on Ki-67 leads to interchromosome attraction via RNA bridging between the two brushes, whereby the RNA preferentially interacts with the charged patches, leading to stable, long-range forces. By contrast, if the brush is uniformly charged, bridging is basically absent due to complete adsorption of RNA onto the brush. Moreover, the RNA dynamics becomes caged in presence of the charged patch while remaining diffusive with uniform charge. Our work sheds light on the physical origin of chromosome clustering, while also suggesting a general mechanism for cells to tune work production by biomolecular condensates via different charge distributions.","lang":"eng"}],"citation":{"ama":"Sorichetti V, Robin P, Palaia I, Hernandez-Armendariz A, Cuylen-Haering S, Šarić A. Charge distribution of the coating brush drives interchromosome attraction. <i>PRX Life</i>. 2025;3(3). doi:<a href=\"https://doi.org/10.1103/41fd-r847\">10.1103/41fd-r847</a>","mla":"Sorichetti, Valerio, et al. “Charge Distribution of the Coating Brush Drives Interchromosome Attraction.” <i>PRX Life</i>, vol. 3, no. 3, 033010, American Physical Society, 2025, doi:<a href=\"https://doi.org/10.1103/41fd-r847\">10.1103/41fd-r847</a>.","ista":"Sorichetti V, Robin P, Palaia I, Hernandez-Armendariz A, Cuylen-Haering S, Šarić A. 2025. Charge distribution of the coating brush drives interchromosome attraction. PRX Life. 3(3), 033010.","ieee":"V. Sorichetti, P. Robin, I. Palaia, A. Hernandez-Armendariz, S. Cuylen-Haering, and A. Šarić, “Charge distribution of the coating brush drives interchromosome attraction,” <i>PRX Life</i>, vol. 3, no. 3. American Physical Society, 2025.","short":"V. Sorichetti, P. Robin, I. Palaia, A. Hernandez-Armendariz, S. Cuylen-Haering, A. Šarić, PRX Life 3 (2025).","chicago":"Sorichetti, Valerio, Paul Robin, Ivan Palaia, Alberto Hernandez-Armendariz, Sara Cuylen-Haering, and Anđela Šarić. “Charge Distribution of the Coating Brush Drives Interchromosome Attraction.” <i>PRX Life</i>. American Physical Society, 2025. <a href=\"https://doi.org/10.1103/41fd-r847\">https://doi.org/10.1103/41fd-r847</a>.","apa":"Sorichetti, V., Robin, P., Palaia, I., Hernandez-Armendariz, A., Cuylen-Haering, S., &#38; Šarić, A. (2025). Charge distribution of the coating brush drives interchromosome attraction. <i>PRX Life</i>. American Physical Society. <a href=\"https://doi.org/10.1103/41fd-r847\">https://doi.org/10.1103/41fd-r847</a>"},"publication":"PRX Life"},{"abstract":[{"text":"Collagen IV is one of the main components of the basement membrane, a layer of material that lines the majority of tissues in multicellular organisms. Collagen IV molecules assemble into networks, providing stiffness and elasticity to tissues and informing cell and organ shape, especially during development. In this work, we develop two coarse-grained models for collagen IV molecules that retain biochemical bond specificity and coarse grain at different length scales. Through molecular-dynamics simulations, we test the assembly and mechanics of the resulting networks and measure their response to strain in terms of stress, microscopic alignment, and bond dynamics. Within the basement membrane, collagen IV networks rearrange by molecule turnover, which affects tissue organization and can be linked with enzyme activity. Here we explore network rearrangements via bond remodeling, the process of breaking and remaking of bonds between network molecules. We then investigate the effects of active (enzymatic) bond remodeling. We find that this nonequilibrium remodeling allows a network to keep its integrity under strain, while relaxing fully over a variety of timescales, a dynamic response that is unavailable to networks undergoing equilibrium remodeling.","lang":"eng"}],"corr_author":"1","citation":{"short":"B. Meadowcroft, V. Sorichetti, E. Ratajczyk, F.L. Perez Verdugo, N. Khalilgharibi, Y. Mao, I. Palaia, A. Šarić, PRX Life 3 (2025).","chicago":"Meadowcroft, Billie, Valerio Sorichetti, Eryk Ratajczyk, Fernanda L Perez Verdugo, Nargess Khalilgharibi, Yanlan Mao, Ivan Palaia, and Anđela Šarić. “Nonequilibrium Remodeling of Collagen IV Networks in Silico.” <i>PRX Life</i>. American Physical Society, 2025. <a href=\"https://doi.org/10.1103/gdd5-rnh7\">https://doi.org/10.1103/gdd5-rnh7</a>.","apa":"Meadowcroft, B., Sorichetti, V., Ratajczyk, E., Perez Verdugo, F. L., Khalilgharibi, N., Mao, Y., … Šarić, A. (2025). Nonequilibrium remodeling of collagen IV networks in Silico. <i>PRX Life</i>. American Physical Society. <a href=\"https://doi.org/10.1103/gdd5-rnh7\">https://doi.org/10.1103/gdd5-rnh7</a>","ieee":"B. Meadowcroft <i>et al.</i>, “Nonequilibrium remodeling of collagen IV networks in Silico,” <i>PRX Life</i>, vol. 3. American Physical Society, 2025.","ista":"Meadowcroft B, Sorichetti V, Ratajczyk E, Perez Verdugo FL, Khalilgharibi N, Mao Y, Palaia I, Šarić A. 2025. Nonequilibrium remodeling of collagen IV networks in Silico. PRX Life. 3, 033019.","ama":"Meadowcroft B, Sorichetti V, Ratajczyk E, et al. Nonequilibrium remodeling of collagen IV networks in Silico. <i>PRX Life</i>. 2025;3. doi:<a href=\"https://doi.org/10.1103/gdd5-rnh7\">10.1103/gdd5-rnh7</a>","mla":"Meadowcroft, Billie, et al. “Nonequilibrium Remodeling of Collagen IV Networks in Silico.” <i>PRX Life</i>, vol. 3, 033019, American Physical Society, 2025, doi:<a href=\"https://doi.org/10.1103/gdd5-rnh7\">10.1103/gdd5-rnh7</a>."},"publication":"PRX Life","acknowledgement":"This work received funding from the European Research Council under the European Union's Horizon 2020 research and innovation program through Grant Agreement No. 802960 (B.M., V.S., I.P., and A.Š.), the European Union's Horizon 2020 research and innovation program under the Marie Skłodowska-Curie Grant Agreement No. 101034413 (I.P.), the NOMIS Foundation (F.P.-V.), the National Centre for the Replacement, Refinement and Reduction of Animals in Research Grant No. NC/T002425/1 (N.K.), Leverhulme Trust project Grant No. RPG-2020-068 (N.K.), MRC Fellowship No. MR/W027437/1 (Y.M.), a Lister Institute Research Prize (Y.M.) and EMBO Young Investigator Programme (Y.M. and A.Š.).","file_date_updated":"2026-02-17T13:36:01Z","date_published":"2025-09-05T00:00:00Z","OA_place":"publisher","publication_identifier":{"eissn":["2835-8279"]},"publisher":"American Physical Society","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"has_accepted_license":"1","volume":3,"article_number":"033019","day":"05","year":"2025","date_created":"2026-02-16T15:55:03Z","oa":1,"quality_controlled":"1","author":[{"last_name":"Meadowcroft","first_name":"Billie","id":"a4725fd6-932b-11ed-81e2-c098c7f37ae1","orcid":"0000-0003-3441-1337","full_name":"Meadowcroft, Billie"},{"last_name":"Sorichetti","first_name":"Valerio","orcid":"0000-0002-9645-6576","id":"ef8a92cb-c7b6-11ec-8bea-e1fd5847bc5b","full_name":"Sorichetti, Valerio"},{"full_name":"Ratajczyk, Eryk","last_name":"Ratajczyk","first_name":"Eryk"},{"id":"4ecec223-9070-11ef-a0a9-bc76077bea8d","first_name":"Fernanda L","last_name":"Perez Verdugo","full_name":"Perez Verdugo, Fernanda L"},{"first_name":"Nargess","last_name":"Khalilgharibi","full_name":"Khalilgharibi, Nargess"},{"last_name":"Mao","first_name":"Yanlan","full_name":"Mao, Yanlan"},{"orcid":" 0000-0002-8843-9485 ","id":"9c805cd2-4b75-11ec-a374-db6dd0ed57fa","first_name":"Ivan","last_name":"Palaia","full_name":"Palaia, Ivan"},{"full_name":"Šarić, Anđela","first_name":"Anđela","last_name":"Šarić","orcid":"0000-0002-7854-2139","id":"bf63d406-f056-11eb-b41d-f263a6566d8b"}],"month":"09","date_updated":"2026-02-17T13:37:38Z","status":"public","publication_status":"published","doi":"10.1103/gdd5-rnh7","intvolume":"         3","ddc":["570"],"_id":"21256","file":[{"date_created":"2026-02-17T13:36:01Z","content_type":"application/pdf","success":1,"checksum":"04cae5231d97e533145c493880fadbd9","file_name":"2025_PRXLife_Meadowcroft.pdf","date_updated":"2026-02-17T13:36:01Z","access_level":"open_access","relation":"main_file","file_size":2277704,"creator":"dernst","file_id":"21308"}],"article_processing_charge":"Yes","language":[{"iso":"eng"}],"OA_type":"gold","department":[{"_id":"AnSa"}],"title":"Nonequilibrium remodeling of collagen IV networks in Silico","article_type":"original","type":"journal_article","oa_version":"Published Version","PlanS_conform":"1","DOAJ_listed":"1","ec_funded":1,"project":[{"_id":"eba2549b-77a9-11ec-83b8-a81e493eae4e","call_identifier":"H2020","grant_number":"802960","name":"Non-Equilibrium Protein Assembly: from Building Blocks to Biological Machines"},{"_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","call_identifier":"H2020","name":"IST-BRIDGE: International postdoctoral program","grant_number":"101034413"},{"name":"EMBO Young Investigator Program - Andela Saric","_id":"349b6ff1-11ca-11ed-8bc3-f006047c2eeb"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"},{"language":[{"iso":"eng"}],"article_processing_charge":"Yes (via OA deal)","OA_type":"hybrid","ddc":["530"],"file":[{"content_type":"application/pdf","date_created":"2025-10-23T11:57:20Z","success":1,"file_name":"2025_PhysReviewLetters_Palaia.pdf","checksum":"e29809fea48b18217d1779980f7117c4","access_level":"open_access","date_updated":"2025-10-23T11:57:20Z","relation":"main_file","file_size":480414,"file_id":"20526","creator":"dernst"}],"_id":"20477","status":"public","issue":"14","publication_status":"published","date_updated":"2025-12-01T15:02:16Z","intvolume":"       135","scopus_import":"1","doi":"10.1103/72b9-c8cq","project":[{"call_identifier":"H2020","grant_number":"101034413","name":"IST-BRIDGE: International postdoctoral program","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c"}],"ec_funded":1,"arxiv":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Charging dynamics of electric double-layer nanocapacitors in mean field","department":[{"_id":"AnSa"}],"type":"journal_article","PlanS_conform":"1","oa_version":"Published Version","article_type":"original","file_date_updated":"2025-10-23T11:57:20Z","acknowledgement":"This work has received funding from the European Union’s Horizon 2020 and Horizon Europe research and innovation programs under the Marie Skłodowska-Curie Grants No. 674979-NANOTRANS (I. P., P. B. W., B. R., E. T.), No. 101034413 (I. P.), and No. 101119598-FLUXIONIC (M. D., B. R., E. T.), as well as from the European Research Council under Grant No. 863473 (B. R.). B. R. acknowledges financial support from the French Agence Nationale de la Recherche (ANR) under Grant No. ANR-21-CE29-0021-02 (DIADEM). I. P. thanks Anđela Šarić for further support at ISTA.","date_published":"2025-09-29T00:00:00Z","external_id":{"arxiv":["2301.00610"],"isi":["001587121300010"]},"publication_identifier":{"issn":["0031-9007"],"eissn":["1079-7114"]},"OA_place":"publisher","has_accepted_license":"1","publisher":"American Physical Society","isi":1,"tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"citation":{"ieee":"I. Palaia, A. J. Asta, M. Dutta, P. B. Warren, B. Rotenberg, and E. Trizac, “Charging dynamics of electric double-layer nanocapacitors in mean field,” <i>Physical Review Letters</i>, vol. 135, no. 14. American Physical Society, 2025.","short":"I. Palaia, A.J. Asta, M. Dutta, P.B. Warren, B. Rotenberg, E. Trizac, Physical Review Letters 135 (2025).","chicago":"Palaia, Ivan, Adelchi J. Asta, Megh Dutta, Patrick B. Warren, Benjamin Rotenberg, and Emmanuel Trizac. “Charging Dynamics of Electric Double-Layer Nanocapacitors in Mean Field.” <i>Physical Review Letters</i>. American Physical Society, 2025. <a href=\"https://doi.org/10.1103/72b9-c8cq\">https://doi.org/10.1103/72b9-c8cq</a>.","apa":"Palaia, I., Asta, A. J., Dutta, M., Warren, P. B., Rotenberg, B., &#38; Trizac, E. (2025). Charging dynamics of electric double-layer nanocapacitors in mean field. <i>Physical Review Letters</i>. American Physical Society. <a href=\"https://doi.org/10.1103/72b9-c8cq\">https://doi.org/10.1103/72b9-c8cq</a>","ama":"Palaia I, Asta AJ, Dutta M, Warren PB, Rotenberg B, Trizac E. Charging dynamics of electric double-layer nanocapacitors in mean field. <i>Physical Review Letters</i>. 2025;135(14). doi:<a href=\"https://doi.org/10.1103/72b9-c8cq\">10.1103/72b9-c8cq</a>","mla":"Palaia, Ivan, et al. “Charging Dynamics of Electric Double-Layer Nanocapacitors in Mean Field.” <i>Physical Review Letters</i>, vol. 135, no. 14, 148002, American Physical Society, 2025, doi:<a href=\"https://doi.org/10.1103/72b9-c8cq\">10.1103/72b9-c8cq</a>.","ista":"Palaia I, Asta AJ, Dutta M, Warren PB, Rotenberg B, Trizac E. 2025. Charging dynamics of electric double-layer nanocapacitors in mean field. Physical Review Letters. 135(14), 148002."},"abstract":[{"text":"An electric double-layer capacitor (EDLC) stores energy by modulating the spatial distribution of ions in the electrolytic solution that it contains. We determine the mean-field timescales for planar EDLC relaxation to equilibrium after a potential difference is applied. We tackle first the fully symmetric case, where positive and negative ionic species have the same valence and diffusivity, and then the general, more complex, asymmetric case. Depending on the applied voltage and salt concentration, different regimes appear, revealing a remarkably rich phenomenology relevant for nanocapacitors.","lang":"eng"}],"corr_author":"1","publication":"Physical Review Letters","oa":1,"month":"09","quality_controlled":"1","author":[{"full_name":"Palaia, Ivan","orcid":" 0000-0002-8843-9485 ","id":"9c805cd2-4b75-11ec-a374-db6dd0ed57fa","first_name":"Ivan","last_name":"Palaia"},{"full_name":"Asta, Adelchi J.","last_name":"Asta","first_name":"Adelchi J."},{"first_name":"Megh","last_name":"Dutta","full_name":"Dutta, Megh"},{"full_name":"Warren, Patrick B.","first_name":"Patrick B.","last_name":"Warren"},{"full_name":"Rotenberg, Benjamin","last_name":"Rotenberg","first_name":"Benjamin"},{"full_name":"Trizac, Emmanuel","first_name":"Emmanuel","last_name":"Trizac"}],"volume":135,"date_created":"2025-10-16T13:09:30Z","day":"29","article_number":"148002","year":"2025"},{"issue":"3","publication_status":"published","status":"public","date_updated":"2025-12-01T13:06:51Z","intvolume":"       112","doi":"10.1103/p4dg-snqf","scopus_import":"1","OA_type":"hybrid","article_processing_charge":"Yes (via OA deal)","language":[{"iso":"eng"}],"file":[{"success":1,"content_type":"application/pdf","date_created":"2025-10-23T09:15:56Z","access_level":"open_access","date_updated":"2025-10-23T09:15:56Z","file_name":"2025_PhysReviewE_Palaia.pdf","checksum":"658a9b1ce6b2edcf138b54c55a566f0e","file_size":1211712,"relation":"main_file","creator":"dernst","file_id":"20521"}],"_id":"20483","ddc":["530"],"title":"Poisson-Nernst-Planck charging dynamics of an electric double-layer capacitor: Symmetric and asymmetric binary electrolytes","department":[{"_id":"AnSa"}],"PlanS_conform":"1","oa_version":"Published Version","type":"journal_article","article_type":"original","project":[{"grant_number":"101034413","name":"IST-BRIDGE: International postdoctoral program","call_identifier":"H2020","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c"}],"ec_funded":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","arxiv":1,"citation":{"apa":"Palaia, I., Asta, A. J., Dutta, M., Warren, P. B., Rotenberg, B., &#38; Trizac, E. (2025). Poisson-Nernst-Planck charging dynamics of an electric double-layer capacitor: Symmetric and asymmetric binary electrolytes. <i>Physical Review E</i>. American Physical Society. <a href=\"https://doi.org/10.1103/p4dg-snqf\">https://doi.org/10.1103/p4dg-snqf</a>","short":"I. Palaia, A.J. Asta, M. Dutta, P.B. Warren, B. Rotenberg, E. Trizac, Physical Review E 112 (2025).","chicago":"Palaia, Ivan, Adelchi J. Asta, Megh Dutta, Patrick B. Warren, Benjamin Rotenberg, and Emmanuel Trizac. “Poisson-Nernst-Planck Charging Dynamics of an Electric Double-Layer Capacitor: Symmetric and Asymmetric Binary Electrolytes.” <i>Physical Review E</i>. American Physical Society, 2025. <a href=\"https://doi.org/10.1103/p4dg-snqf\">https://doi.org/10.1103/p4dg-snqf</a>.","ieee":"I. Palaia, A. J. Asta, M. Dutta, P. B. Warren, B. Rotenberg, and E. Trizac, “Poisson-Nernst-Planck charging dynamics of an electric double-layer capacitor: Symmetric and asymmetric binary electrolytes,” <i>Physical Review E</i>, vol. 112, no. 3. American Physical Society, 2025.","ista":"Palaia I, Asta AJ, Dutta M, Warren PB, Rotenberg B, Trizac E. 2025. Poisson-Nernst-Planck charging dynamics of an electric double-layer capacitor: Symmetric and asymmetric binary electrolytes. Physical Review E. 112(3), 035417.","mla":"Palaia, Ivan, et al. “Poisson-Nernst-Planck Charging Dynamics of an Electric Double-Layer Capacitor: Symmetric and Asymmetric Binary Electrolytes.” <i>Physical Review E</i>, vol. 112, no. 3, 035417, American Physical Society, 2025, doi:<a href=\"https://doi.org/10.1103/p4dg-snqf\">10.1103/p4dg-snqf</a>.","ama":"Palaia I, Asta AJ, Dutta M, Warren PB, Rotenberg B, Trizac E. Poisson-Nernst-Planck charging dynamics of an electric double-layer capacitor: Symmetric and asymmetric binary electrolytes. <i>Physical Review E</i>. 2025;112(3). doi:<a href=\"https://doi.org/10.1103/p4dg-snqf\">10.1103/p4dg-snqf</a>"},"corr_author":"1","abstract":[{"lang":"eng","text":"A parallel plate capacitor containing an electrolytic solution is the simplest model of a supercapacitor or electric double-layer capacitor. Using both analytical and numerical techniques, we solve the Poisson-Nernst-Planck equations for such a system, describing the mean-field charging dynamics of the capacitor, when a constant potential difference is abruptly applied to its plates. Working at constant total number of ions, we focus on the physical processes involved in the relaxation and, whenever possible, give its functional shape and exact time constants. We first review and study the case of a symmetric binary electrolyte, where we assume the two ionic species to have the same charges and diffusivities. We then relax these assumptions and present results for a generic strong (i.e fully dissociated) binary electrolyte. At low electrolyte concentration, the relaxation is simple to understand, as the dynamics of positive and negative ions appear decoupled. At higher electrolyte concentration, we distinguish several regimes. In the linear regime (low voltages), relaxation is multiexponential, it starts by the buildup of the equilibrium charge profile and continues with neutral mass diffusion, and the relevant timescales feature both the average and the Nernst-Hartley diffusion coefficients. In the purely nonlinear regime (intermediate voltages), the initial relaxation is slowed down exponentially due to increased capacitance, while bulk effects become more and more evident. In the fully nonlinear regime (high voltages), the dynamics of charge and mass are completely entangled and, asymptotically, the relaxation is linear in time. We finally discuss nonideal behavior in real capacitors and provide conditions for which mean-field is expected to hold."}],"publication":"Physical Review E","publication_identifier":{"eissn":["2470-0053"],"issn":["2470-0045"]},"OA_place":"publisher","external_id":{"isi":["001586173200001"],"arxiv":["2303.07859"]},"acknowledgement":"This work has received funding from the European Union's Horizon 2020 and Horizon Europe research and innovation programs under the Marie Skłodowska-Curie Grants No. 674979-NANOTRANS (I.P., P.B.W., B.R., and E.T.), No. 101034413 (I.P.), and No. 101119598-FLUXIONIC (M.D., B.R., and E.T.), as well as from the European Research Council under Grant No. 863473 (B.R.). B.R. acknowledges financial support from the French Agence Nationale de la Recherche (ANR) under Grant No. ANR-21-CE29-0021-02 (DIADEM). I.P. thanks Anđela Šarić for further support at ISTA.","date_published":"2025-09-29T00:00:00Z","file_date_updated":"2025-10-23T09:15:56Z","has_accepted_license":"1","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"publisher":"American Physical Society","isi":1,"volume":112,"date_created":"2025-10-16T13:15:16Z","year":"2025","article_number":"035417","day":"29","oa":1,"month":"09","author":[{"full_name":"Palaia, Ivan","first_name":"Ivan","last_name":"Palaia","id":"9c805cd2-4b75-11ec-a374-db6dd0ed57fa","orcid":" 0000-0002-8843-9485 "},{"last_name":"Asta","first_name":"Adelchi J.","full_name":"Asta, Adelchi J."},{"full_name":"Dutta, Megh","last_name":"Dutta","first_name":"Megh"},{"first_name":"Patrick B.","last_name":"Warren","full_name":"Warren, Patrick B."},{"full_name":"Rotenberg, Benjamin","last_name":"Rotenberg","first_name":"Benjamin"},{"first_name":"Emmanuel","last_name":"Trizac","full_name":"Trizac, Emmanuel"}],"quality_controlled":"1"},{"department":[{"_id":"EdHa"},{"_id":"AnSa"},{"_id":"JePa"}],"title":"Unconventional colloidal aggregation in chiral bacterial baths","article_type":"original","type":"journal_article","oa_version":"Published Version","ec_funded":1,"project":[{"_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","name":"IST-BRIDGE: International postdoctoral program","grant_number":"101034413","call_identifier":"H2020"},{"call_identifier":"H2020","grant_number":"802960","name":"Non-Equilibrium Protein Assembly: from Building Blocks to Biological Machines","_id":"eba2549b-77a9-11ec-83b8-a81e493eae4e"},{"call_identifier":"H2020","name":"ISTplus - Postdoctoral Fellowships","grant_number":"754411","_id":"260C2330-B435-11E9-9278-68D0E5697425"}],"page":"1680-1688","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2025-04-14T07:43:56Z","status":"public","publication_status":"published","scopus_import":"1","doi":"10.1038/s41567-023-02136-x","intvolume":"        19","ddc":["530"],"_id":"13971","file":[{"file_name":"2023_NaturePhysics_Grober.pdf","checksum":"7e282c2ebc0ac82125a04f6b4742d4c1","access_level":"open_access","date_updated":"2024-01-30T12:26:08Z","content_type":"application/pdf","date_created":"2024-01-30T12:26:08Z","success":1,"creator":"dernst","file_id":"14906","file_size":6365607,"relation":"main_file"}],"language":[{"iso":"eng"}],"article_processing_charge":"Yes","volume":19,"day":"01","year":"2023","date_created":"2023-08-06T22:01:11Z","oa":1,"quality_controlled":"1","author":[{"first_name":"Daniel","last_name":"Grober","id":"abdfc56f-34fb-11ee-bd33-fd766fce5a99","full_name":"Grober, Daniel"},{"last_name":"Palaia","first_name":"Ivan","orcid":" 0000-0002-8843-9485 ","id":"9c805cd2-4b75-11ec-a374-db6dd0ed57fa","full_name":"Palaia, Ivan"},{"first_name":"Mehmet C","last_name":"Ucar","orcid":"0000-0003-0506-4217","id":"50B2A802-6007-11E9-A42B-EB23E6697425","full_name":"Ucar, Mehmet C"},{"full_name":"Hannezo, Edouard B","orcid":"0000-0001-6005-1561","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","first_name":"Edouard B","last_name":"Hannezo"},{"last_name":"Šarić","first_name":"Anđela","orcid":"0000-0002-7854-2139","id":"bf63d406-f056-11eb-b41d-f263a6566d8b","full_name":"Šarić, Anđela"},{"first_name":"Jérémie A","last_name":"Palacci","id":"8fb92548-2b22-11eb-b7c1-a3f0d08d7c7d","orcid":"0000-0002-7253-9465","full_name":"Palacci, Jérémie A"}],"month":"11","abstract":[{"lang":"eng","text":"When in equilibrium, thermal forces agitate molecules, which then diffuse, collide and bind to form materials. However, the space of accessible structures in which micron-scale particles can be organized by thermal forces is limited, owing to the slow dynamics and metastable states. Active agents in a passive fluid generate forces and flows, forming a bath with active fluctuations. Two unanswered questions are whether those active agents can drive the assembly of passive components into unconventional states and which material properties they will exhibit. Here we show that passive, sticky beads immersed in a bath of swimming Escherichia coli bacteria aggregate into unconventional clusters and gels that are controlled by the activity of the bath. We observe a slow but persistent rotation of the aggregates that originates in the chirality of the E. coli flagella and directs aggregation into structures that are not accessible thermally. We elucidate the aggregation mechanism with a numerical model of spinning, sticky beads and reproduce quantitatively the experimental results. We show that internal activity controls the phase diagram and the structure of the aggregates. Overall, our results highlight the promising role of active baths in designing the structural and mechanical properties of materials with unconventional phases."}],"corr_author":"1","citation":{"ieee":"D. Grober, I. Palaia, M. C. Ucar, E. B. Hannezo, A. Šarić, and J. A. Palacci, “Unconventional colloidal aggregation in chiral bacterial baths,” <i>Nature Physics</i>, vol. 19. Springer Nature, pp. 1680–1688, 2023.","apa":"Grober, D., Palaia, I., Ucar, M. C., Hannezo, E. B., Šarić, A., &#38; Palacci, J. A. (2023). Unconventional colloidal aggregation in chiral bacterial baths. <i>Nature Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41567-023-02136-x\">https://doi.org/10.1038/s41567-023-02136-x</a>","short":"D. Grober, I. Palaia, M.C. Ucar, E.B. Hannezo, A. Šarić, J.A. Palacci, Nature Physics 19 (2023) 1680–1688.","chicago":"Grober, Daniel, Ivan Palaia, Mehmet C Ucar, Edouard B Hannezo, Anđela Šarić, and Jérémie A Palacci. “Unconventional Colloidal Aggregation in Chiral Bacterial Baths.” <i>Nature Physics</i>. Springer Nature, 2023. <a href=\"https://doi.org/10.1038/s41567-023-02136-x\">https://doi.org/10.1038/s41567-023-02136-x</a>.","mla":"Grober, Daniel, et al. “Unconventional Colloidal Aggregation in Chiral Bacterial Baths.” <i>Nature Physics</i>, vol. 19, Springer Nature, 2023, pp. 1680–88, doi:<a href=\"https://doi.org/10.1038/s41567-023-02136-x\">10.1038/s41567-023-02136-x</a>.","ama":"Grober D, Palaia I, Ucar MC, Hannezo EB, Šarić A, Palacci JA. Unconventional colloidal aggregation in chiral bacterial baths. <i>Nature Physics</i>. 2023;19:1680-1688. doi:<a href=\"https://doi.org/10.1038/s41567-023-02136-x\">10.1038/s41567-023-02136-x</a>","ista":"Grober D, Palaia I, Ucar MC, Hannezo EB, Šarić A, Palacci JA. 2023. Unconventional colloidal aggregation in chiral bacterial baths. Nature Physics. 19, 1680–1688."},"publication":"Nature Physics","acknowledgement":"D.G. and J.P. thank E. Krasnopeeva, C. Guet, G. Guessous and T. Hwa for providing the E. coli strains. This material is based upon work supported by the US Department of Energy under award DE-SC0019769. I.P. acknowledges funding by the European Union’s Horizon 2020 research and innovation programme under Marie Skłodowska-Curie Grant Agreement No. 101034413. A.Š. acknowledges funding from the European Research Council under the European Union’s Horizon 2020 research and innovation programme (Grant No. 802960). M.C.U. acknowledges funding from the European Union’s Horizon 2020 research and innovation programme under Marie Skłodowska-Curie Grant Agreement No. 754411.","date_published":"2023-11-01T00:00:00Z","external_id":{"isi":["001037346400005"]},"file_date_updated":"2024-01-30T12:26:08Z","publication_identifier":{"eissn":["1745-2481"],"issn":["1745-2473"]},"publisher":"Springer Nature","isi":1,"tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"has_accepted_license":"1"},{"article_processing_charge":"No","language":[{"iso":"eng"}],"_id":"11340","status":"public","issue":"16","publication_status":"published","date_updated":"2025-06-11T13:34:36Z","intvolume":"       126","doi":"10.1021/acs.jpcb.2c00028","scopus_import":"1","arxiv":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","page":"3143-3149","title":"Like-charge attraction at the nanoscale: Ground-state correlations and water destructuring","department":[{"_id":"AnSa"}],"type":"journal_article","oa_version":"Preprint","article_type":"original","date_published":"2022-04-14T00:00:00Z","external_id":{"pmid":["35420420"],"arxiv":["2203.10524"],"isi":["000796953700022"]},"acknowledgement":"We thank Martin Trulsson for useful discussions and for providing us with simulation data. This work has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement 674979-NANOTRANS. The support received from VEGA Grant No. 2/0092/21 is acknowledged.","publication_identifier":{"eissn":["1520-5207"],"issn":["1520-6106"]},"pmid":1,"isi":1,"publisher":"American Chemical Society","citation":{"short":"I. Palaia, A. Goyal, E. Del Gado, L. Šamaj, E. Trizac, Journal of Physical Chemistry B 126 (2022) 3143–3149.","chicago":"Palaia, Ivan, Abhay Goyal, Emanuela Del Gado, Ladislav Šamaj, and Emmanuel Trizac. “Like-Charge Attraction at the Nanoscale: Ground-State Correlations and Water Destructuring.” <i>Journal of Physical Chemistry B</i>. American Chemical Society, 2022. <a href=\"https://doi.org/10.1021/acs.jpcb.2c00028\">https://doi.org/10.1021/acs.jpcb.2c00028</a>.","apa":"Palaia, I., Goyal, A., Del Gado, E., Šamaj, L., &#38; Trizac, E. (2022). Like-charge attraction at the nanoscale: Ground-state correlations and water destructuring. <i>Journal of Physical Chemistry B</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/acs.jpcb.2c00028\">https://doi.org/10.1021/acs.jpcb.2c00028</a>","ieee":"I. Palaia, A. Goyal, E. Del Gado, L. Šamaj, and E. Trizac, “Like-charge attraction at the nanoscale: Ground-state correlations and water destructuring,” <i>Journal of Physical Chemistry B</i>, vol. 126, no. 16. American Chemical Society, pp. 3143–3149, 2022.","ista":"Palaia I, Goyal A, Del Gado E, Šamaj L, Trizac E. 2022. Like-charge attraction at the nanoscale: Ground-state correlations and water destructuring. Journal of Physical Chemistry B. 126(16), 3143–3149.","ama":"Palaia I, Goyal A, Del Gado E, Šamaj L, Trizac E. Like-charge attraction at the nanoscale: Ground-state correlations and water destructuring. <i>Journal of Physical Chemistry B</i>. 2022;126(16):3143-3149. doi:<a href=\"https://doi.org/10.1021/acs.jpcb.2c00028\">10.1021/acs.jpcb.2c00028</a>","mla":"Palaia, Ivan, et al. “Like-Charge Attraction at the Nanoscale: Ground-State Correlations and Water Destructuring.” <i>Journal of Physical Chemistry B</i>, vol. 126, no. 16, American Chemical Society, 2022, pp. 3143–49, doi:<a href=\"https://doi.org/10.1021/acs.jpcb.2c00028\">10.1021/acs.jpcb.2c00028</a>."},"abstract":[{"lang":"eng","text":"Like-charge attraction, driven by ionic correlations, challenges our understanding of electrostatics both in soft and hard matter. For two charged planar surfaces confining counterions and water, we prove that, even at relatively low correlation strength, the relevant physics is the ground-state one, oblivious of fluctuations. Based on this, we derive a simple and accurate interaction pressure that fulfills known exact requirements and can be used as an effective potential. We test this equation against implicit-solvent Monte Carlo simulations and against explicit-solvent simulations of cement and several types of clays. We argue that water destructuring under nanometric confinement drastically reduces dielectric screening, enhancing ionic correlations. Our equation of state at reduced permittivity therefore explains the exotic attractive regime reported for these materials, even in the absence of multivalent counterions."}],"main_file_link":[{"open_access":"1","url":" https://doi.org/10.48550/arXiv.2203.10524"}],"publication":"Journal of Physical Chemistry B","oa":1,"month":"04","quality_controlled":"1","author":[{"last_name":"Palaia","first_name":"Ivan","orcid":" 0000-0002-8843-9485 ","id":"9c805cd2-4b75-11ec-a374-db6dd0ed57fa","full_name":"Palaia, Ivan"},{"full_name":"Goyal, Abhay","last_name":"Goyal","first_name":"Abhay"},{"full_name":"Del Gado, Emanuela","first_name":"Emanuela","last_name":"Del Gado"},{"last_name":"Šamaj","first_name":"Ladislav","full_name":"Šamaj, Ladislav"},{"last_name":"Trizac","first_name":"Emmanuel","full_name":"Trizac, Emmanuel"}],"volume":126,"date_created":"2022-05-01T22:01:42Z","day":"14","year":"2022"},{"pmid":1,"publication_identifier":{"eissn":["1089-7690"],"issn":["0021-9606"]},"file_date_updated":"2022-05-23T07:45:33Z","acknowledgement":"The authors thank Longhui Zeng and Xiaolei Su (Yale University) for bringing the topic to their attention and for useful comments. This work has received funding from the European Research Council under the European Union’s Horizon\r\n2020 research and innovation program (ERC Grant No. 802960 and Marie Skłodowska-Curie Grant No. 101034413). The authors are grateful to the UK Materials and Molecular Modeling Hub for computational resources, which is partially funded by EPSRC (Grant Nos. EP/P020194/1 and EP/T022213/1). The authors acknowledge support from ISTA and from the Royal Society (Grant No. UF160266).","date_published":"2022-05-16T00:00:00Z","external_id":{"isi":["000797236000004"],"pmid":["35597653"]},"tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"publisher":"AIP Publishing","isi":1,"has_accepted_license":"1","corr_author":"1","abstract":[{"text":"By varying the concentration of molecules in the cytoplasm or on the membrane, cells can induce the formation of condensates and liquid droplets, similar to phase separation. Their thermodynamics, much studied, depends on the mutual interactions between microscopic constituents. Here, we focus on the kinetics and size control of 2D clusters, forming on membranes. Using molecular dynamics of patchy colloids, we model a system of two species of proteins, giving origin to specific heterotypic bonds. We find that concentrations, together with valence and bond strength, control both the size and the growth time rate of the clusters. In particular, if one species is in large excess, it gradually saturates the binding sites of the other species; the system then becomes kinetically arrested and cluster coarsening slows down or stops, thus yielding effective size selection. This phenomenology is observed both in solid and fluid clusters, which feature additional generic homotypic interactions and are reminiscent of the ones observed on biological membranes.","lang":"eng"}],"citation":{"mla":"Palaia, Ivan, and Anđela Šarić. “Controlling Cluster Size in 2D Phase-Separating Binary Mixtures with Specific Interactions.” <i>The Journal of Chemical Physics</i>, vol. 156, no. 19, 194902, AIP Publishing, 2022, doi:<a href=\"https://doi.org/10.1063/5.0087769\">10.1063/5.0087769</a>.","ama":"Palaia I, Šarić A. Controlling cluster size in 2D phase-separating binary mixtures with specific interactions. <i>The Journal of Chemical Physics</i>. 2022;156(19). doi:<a href=\"https://doi.org/10.1063/5.0087769\">10.1063/5.0087769</a>","ista":"Palaia I, Šarić A. 2022. Controlling cluster size in 2D phase-separating binary mixtures with specific interactions. The Journal of Chemical Physics. 156(19), 194902.","ieee":"I. Palaia and A. Šarić, “Controlling cluster size in 2D phase-separating binary mixtures with specific interactions,” <i>The Journal of Chemical Physics</i>, vol. 156, no. 19. AIP Publishing, 2022.","apa":"Palaia, I., &#38; Šarić, A. (2022). Controlling cluster size in 2D phase-separating binary mixtures with specific interactions. <i>The Journal of Chemical Physics</i>. AIP Publishing. <a href=\"https://doi.org/10.1063/5.0087769\">https://doi.org/10.1063/5.0087769</a>","chicago":"Palaia, Ivan, and Anđela Šarić. “Controlling Cluster Size in 2D Phase-Separating Binary Mixtures with Specific Interactions.” <i>The Journal of Chemical Physics</i>. AIP Publishing, 2022. <a href=\"https://doi.org/10.1063/5.0087769\">https://doi.org/10.1063/5.0087769</a>.","short":"I. Palaia, A. Šarić, The Journal of Chemical Physics 156 (2022)."},"publication":"The Journal of Chemical Physics","oa":1,"author":[{"first_name":"Ivan","last_name":"Palaia","id":"9c805cd2-4b75-11ec-a374-db6dd0ed57fa","orcid":" 0000-0002-8843-9485 ","full_name":"Palaia, Ivan"},{"full_name":"Šarić, Anđela","first_name":"Anđela","last_name":"Šarić","id":"bf63d406-f056-11eb-b41d-f263a6566d8b","orcid":"0000-0002-7854-2139"}],"quality_controlled":"1","month":"05","volume":156,"year":"2022","day":"16","article_number":"194902","date_created":"2022-05-22T17:04:48Z","_id":"11400","file":[{"file_id":"11405","creator":"dernst","file_size":6387208,"relation":"main_file","checksum":"7fada58059676a4bb0944b82247af740","file_name":"2022_JourChemPhysics_Palaia.pdf","date_updated":"2022-05-23T07:45:33Z","access_level":"open_access","date_created":"2022-05-23T07:45:33Z","content_type":"application/pdf","success":1}],"ddc":["540"],"language":[{"iso":"eng"}],"article_processing_charge":"No","date_updated":"2025-06-11T14:00:32Z","publication_status":"published","issue":"19","status":"public","scopus_import":"1","doi":"10.1063/5.0087769","intvolume":"       156","ec_funded":1,"project":[{"_id":"eba2549b-77a9-11ec-83b8-a81e493eae4e","call_identifier":"H2020","grant_number":"802960","name":"Non-Equilibrium Protein Assembly: from Building Blocks to Biological Machines"},{"_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","name":"IST-BRIDGE: International postdoctoral program","grant_number":"101034413","call_identifier":"H2020"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"AnSa"}],"title":"Controlling cluster size in 2D phase-separating binary mixtures with specific interactions","article_type":"original","keyword":["Physical and Theoretical Chemistry","General Physics and Astronomy"],"oa_version":"Published Version","type":"journal_article"},{"date_created":"2023-01-08T23:00:53Z","year":"2022","day":"23","article_number":"268101","volume":129,"month":"12","author":[{"full_name":"Meadowcroft, Billie","first_name":"Billie","last_name":"Meadowcroft","id":"a4725fd6-932b-11ed-81e2-c098c7f37ae1","orcid":"0000-0003-3441-1337"},{"full_name":"Palaia, Ivan","id":"9c805cd2-4b75-11ec-a374-db6dd0ed57fa","orcid":" 0000-0002-8843-9485 ","last_name":"Palaia","first_name":"Ivan"},{"full_name":"Pfitzner, Anna Katharina","first_name":"Anna Katharina","last_name":"Pfitzner"},{"full_name":"Roux, Aurélien","last_name":"Roux","first_name":"Aurélien"},{"full_name":"Baum, Buzz","last_name":"Baum","first_name":"Buzz"},{"first_name":"Anđela","last_name":"Šarić","id":"bf63d406-f056-11eb-b41d-f263a6566d8b","orcid":"0000-0002-7854-2139","full_name":"Šarić, Anđela"}],"quality_controlled":"1","oa":1,"publication":"Physical Review Letters","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1101/2022.05.10.490642 "}],"citation":{"ieee":"B. Meadowcroft, I. Palaia, A. K. Pfitzner, A. Roux, B. Baum, and A. Šarić, “Mechanochemical rules for shape-shifting filaments that remodel membranes,” <i>Physical Review Letters</i>, vol. 129, no. 26. American Physical Society, 2022.","apa":"Meadowcroft, B., Palaia, I., Pfitzner, A. K., Roux, A., Baum, B., &#38; Šarić, A. (2022). Mechanochemical rules for shape-shifting filaments that remodel membranes. <i>Physical Review Letters</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevLett.129.268101\">https://doi.org/10.1103/PhysRevLett.129.268101</a>","chicago":"Meadowcroft, Billie, Ivan Palaia, Anna Katharina Pfitzner, Aurélien Roux, Buzz Baum, and Anđela Šarić. “Mechanochemical Rules for Shape-Shifting Filaments That Remodel Membranes.” <i>Physical Review Letters</i>. American Physical Society, 2022. <a href=\"https://doi.org/10.1103/PhysRevLett.129.268101\">https://doi.org/10.1103/PhysRevLett.129.268101</a>.","short":"B. Meadowcroft, I. Palaia, A.K. Pfitzner, A. Roux, B. Baum, A. Šarić, Physical Review Letters 129 (2022).","mla":"Meadowcroft, Billie, et al. “Mechanochemical Rules for Shape-Shifting Filaments That Remodel Membranes.” <i>Physical Review Letters</i>, vol. 129, no. 26, 268101, American Physical Society, 2022, doi:<a href=\"https://doi.org/10.1103/PhysRevLett.129.268101\">10.1103/PhysRevLett.129.268101</a>.","ama":"Meadowcroft B, Palaia I, Pfitzner AK, Roux A, Baum B, Šarić A. Mechanochemical rules for shape-shifting filaments that remodel membranes. <i>Physical Review Letters</i>. 2022;129(26). doi:<a href=\"https://doi.org/10.1103/PhysRevLett.129.268101\">10.1103/PhysRevLett.129.268101</a>","ista":"Meadowcroft B, Palaia I, Pfitzner AK, Roux A, Baum B, Šarić A. 2022. Mechanochemical rules for shape-shifting filaments that remodel membranes. Physical Review Letters. 129(26), 268101."},"corr_author":"1","abstract":[{"text":"The sequential exchange of filament composition to increase filament curvature was proposed as a mechanism for how some biological polymers deform and cut membranes. The relationship between the filament composition and its mechanical effect is lacking. We develop a kinetic model for the assembly of composite filaments that includes protein–membrane adhesion, filament mechanics and membrane mechanics. We identify the physical conditions for such a membrane remodeling and show this mechanism of sequential polymer assembly lowers the energetic barrier for membrane deformation.","lang":"eng"}],"publisher":"American Physical Society","isi":1,"publication_identifier":{"issn":["0031-9007"],"eissn":["1079-7114"]},"external_id":{"isi":["000906721500001"],"pmid":["36608212"]},"acknowledgement":"We thank T. C. T. Michaels and J. Palacci for useful discussions. We thank Claudia Flandoli for the illustrations in Fig. 1(b) and Fig. 2. We acknowledge funding by the European Union’s Horizon 2020 Research and Innovation Programme under the Marie Skłodowska-Curie Grant\r\nAgreement No. 101034413 (I. P.), the Royal Society Grant No. UF160266 (A. Š.), the European Research Council under the European Union’s Horizon 2020 Research and Innovation Programme (Grant No. 802960; B. M., I. P., and A. Š.), and the Volkswagen Foundation\r\nLife Grant (B. B. and A. Š). ","date_published":"2022-12-23T00:00:00Z","pmid":1,"oa_version":"Preprint","type":"journal_article","article_type":"original","title":"Mechanochemical rules for shape-shifting filaments that remodel membranes","department":[{"_id":"AnSa"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","project":[{"name":"IST-BRIDGE: International postdoctoral program","grant_number":"101034413","call_identifier":"H2020","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c"},{"call_identifier":"H2020","name":"Non-Equilibrium Protein Assembly: from Building Blocks to Biological Machines","grant_number":"802960","_id":"eba2549b-77a9-11ec-83b8-a81e493eae4e"},{"_id":"eba0f67c-77a9-11ec-83b8-cc8501b3e222","name":"The evolution of trafficking: from archaea to eukaryotes","grant_number":"96752"}],"ec_funded":1,"intvolume":"       129","doi":"10.1103/PhysRevLett.129.268101","scopus_import":"1","publication_status":"published","issue":"26","status":"public","date_updated":"2025-04-14T07:54:53Z","article_processing_charge":"No","language":[{"iso":"eng"}],"_id":"12108"}]