TY - JOUR AB - Adenosine triphosphate (ATP) is the energy source for various biochemical processes and biomolecular motors in living things. Development of ATP antagonists and their stimuli-controlled actions offer a novel approach to regulate biological processes. Herein, we developed azobenzene-based photoswitchable ATP antagonists for controlling the activity of motor proteins; cytoplasmic and axonemal dyneins. The new ATP antagonists showed reversible photoswitching of cytoplasmic dynein activity in an in vitro dynein-microtubule system due to the trans and cis photoisomerization of their azobenzene segment. Importantly, our ATP antagonists reversibly regulated the axonemal dynein motor activity for the force generation in a demembranated model of Chlamydomonas reinhardtii. We found that the trans and cis isomers of ATP antagonists significantly differ in their affinity to the ATP binding site. AU - Thayyil, Sampreeth AU - Nishigami, Yukinori AU - Islam, Muhammad J AU - Hashim, P. K. AU - Furuta, Ken'Ya AU - Oiwa, Kazuhiro AU - Yu, Jian AU - Yao, Min AU - Nakagaki, Toshiyuki AU - Tamaoki, Nobuyuki ID - 11333 IS - 30 JF - Chemistry - A European Journal SN - 09476539 TI - Dynamic control of microbial movement by photoswitchable ATP antagonists VL - 28 ER -