[{"oa_version":"Preprint","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","_id":"8602","title":"Theory of mechanochemical patterning and optimal migration in cell monolayers","status":"public","intvolume":" 17","abstract":[{"text":"Collective cell migration offers a rich field of study for non-equilibrium physics and cellular biology, revealing phenomena such as glassy dynamics, pattern formation and active turbulence. However, how mechanical and chemical signalling are integrated at the cellular level to give rise to such collective behaviours remains unclear. We address this by focusing on the highly conserved phenomenon of spatiotemporal waves of density and extracellular signal-regulated kinase (ERK) activation, which appear both in vitro and in vivo during collective cell migration and wound healing. First, we propose a biophysical theory, backed by mechanical and optogenetic perturbation experiments, showing that patterns can be quantitatively explained by a mechanochemical coupling between active cellular tensions and the mechanosensitive ERK pathway. Next, we demonstrate how this biophysical mechanism can robustly induce long-ranged order and migration in a desired orientation, and we determine the theoretically optimal wavelength and period for inducing maximal migration towards free edges, which fits well with experimentally observed dynamics. We thereby provide a bridge between the biophysical origin of spatiotemporal instabilities and the design principles of robust and efficient long-ranged migration.","lang":"eng"}],"type":"journal_article","date_published":"2021-02-01T00:00:00Z","publication":"Nature Physics","citation":{"chicago":"Boocock, Daniel R, Naoya Hino, Natalia Ruzickova, Tsuyoshi Hirashima, and Edouard B Hannezo. “Theory of Mechanochemical Patterning and Optimal Migration in Cell Monolayers.” Nature Physics. Springer Nature, 2021. https://doi.org/10.1038/s41567-020-01037-7.","short":"D.R. Boocock, N. Hino, N. Ruzickova, T. Hirashima, E.B. Hannezo, Nature Physics 17 (2021) 267–274.","mla":"Boocock, Daniel R., et al. “Theory of Mechanochemical Patterning and Optimal Migration in Cell Monolayers.” Nature Physics, vol. 17, Springer Nature, 2021, pp. 267–74, doi:10.1038/s41567-020-01037-7.","apa":"Boocock, D. R., Hino, N., Ruzickova, N., Hirashima, T., & Hannezo, E. B. (2021). Theory of mechanochemical patterning and optimal migration in cell monolayers. Nature Physics. Springer Nature. https://doi.org/10.1038/s41567-020-01037-7","ieee":"D. R. Boocock, N. Hino, N. Ruzickova, T. Hirashima, and E. B. Hannezo, “Theory of mechanochemical patterning and optimal migration in cell monolayers,” Nature Physics, vol. 17. Springer Nature, pp. 267–274, 2021.","ista":"Boocock DR, Hino N, Ruzickova N, Hirashima T, Hannezo EB. 2021. Theory of mechanochemical patterning and optimal migration in cell monolayers. Nature Physics. 17, 267–274.","ama":"Boocock DR, Hino N, Ruzickova N, Hirashima T, Hannezo EB. Theory of mechanochemical patterning and optimal migration in cell monolayers. Nature Physics. 2021;17:267-274. doi:10.1038/s41567-020-01037-7"},"article_type":"original","page":"267-274","day":"01","article_processing_charge":"No","scopus_import":"1","author":[{"first_name":"Daniel R","last_name":"Boocock","id":"453AF628-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-1585-2631","full_name":"Boocock, Daniel R"},{"full_name":"Hino, Naoya","last_name":"Hino","first_name":"Naoya"},{"last_name":"Ruzickova","first_name":"Natalia","id":"D2761128-D73D-11E9-A1BF-BA0DE6697425","full_name":"Ruzickova, Natalia"},{"full_name":"Hirashima, Tsuyoshi","last_name":"Hirashima","first_name":"Tsuyoshi"},{"full_name":"Hannezo, Edouard B","orcid":"0000-0001-6005-1561","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","last_name":"Hannezo","first_name":"Edouard B"}],"related_material":{"link":[{"url":"https://ist.ac.at/en/news/wound-healing-waves/","description":"News on IST Homepage","relation":"press_release"}],"record":[{"relation":"dissertation_contains","status":"public","id":"12964"}]},"date_created":"2020-10-04T22:01:37Z","date_updated":"2023-08-04T11:02:41Z","volume":17,"acknowledgement":"We would like to thank G. Tkacik and all of the members of the Hannezo and Hirashima groups for useful discussions, X. Trepat for help on traction force microscopy and M. Matsuda for use of the lab facility. E.H. acknowledges grants from the Austrian Science Fund (FWF) (P 31639) and the European Research Council (851288). T.H. acknowledges a grant from JST, PRESTO (JPMJPR1949). This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement no. 665385 (to D.B.), from JSPS KAKENHI grant no. 17J02107 (to N.H.) and from the SPIRITS 2018 of Kyoto University (to E.H. and T.H.).","year":"2021","publication_status":"published","department":[{"_id":"EdHa"}],"publisher":"Springer Nature","ec_funded":1,"doi":"10.1038/s41567-020-01037-7","language":[{"iso":"eng"}],"external_id":{"isi":["000573519500002"]},"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1101/2020.05.15.096479"}],"oa":1,"isi":1,"quality_controlled":"1","project":[{"name":"Active mechano-chemical description of the cell cytoskeleton","call_identifier":"FWF","grant_number":"P31639","_id":"268294B6-B435-11E9-9278-68D0E5697425"},{"_id":"05943252-7A3F-11EA-A408-12923DDC885E","grant_number":"851288","name":"Design Principles of Branching Morphogenesis","call_identifier":"H2020"},{"name":"International IST Doctoral Program","call_identifier":"H2020","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","grant_number":"665385"}],"month":"02","publication_identifier":{"issn":["17452473"],"eissn":["17452481"]}},{"type":"journal_article","abstract":[{"text":"Our ability to trust that a random number is truly random is essential for fields as diverse as cryptography and fundamental tests of quantum mechanics. Existing solutions both come with drawbacks—device-independent quantum random number generators (QRNGs) are highly impractical and standard semi-device-independent QRNGs are limited to a specific physical implementation and level of trust. Here we propose a framework for semi-device-independent randomness certification, using a source of trusted vacuum in the form of a signal shutter. It employs a flexible set of assumptions and levels of trust, allowing it to be applied in a wide range of physical scenarios involving both quantum and classical entropy sources. We experimentally demonstrate our protocol with a photonic setup and generate secure random bits under three different assumptions with varying degrees of security and resulting data rates.","lang":"eng"}],"_id":"9255","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","status":"public","title":"Semi-device-independent random number generation with flexible assumptions","ddc":["530"],"intvolume":" 7","oa_version":"Published Version","file":[{"file_name":"2021_NPJQuantumInformation_Pivoluska.pdf","access_level":"open_access","creator":"dernst","file_size":1360271,"content_type":"application/pdf","file_id":"9274","relation":"main_file","date_updated":"2021-03-22T11:09:34Z","date_created":"2021-03-22T11:09:34Z","success":1,"checksum":"26d3f2a2c8c8fa8c1002028326b45f64"}],"scopus_import":"1","day":"15","article_processing_charge":"No","has_accepted_license":"1","publication":"npj Quantum Information","citation":{"chicago":"Pivoluska, Matej, Martin Plesch, Máté Farkas, Natalia Ruzickova, Clara Flegel, Natalia Herrera Valencia, Will Mccutcheon, Mehul Malik, and Edgar A. Aguilar. “Semi-Device-Independent Random Number Generation with Flexible Assumptions.” Npj Quantum Information. Springer Nature, 2021. https://doi.org/10.1038/s41534-021-00387-1.","short":"M. Pivoluska, M. Plesch, M. Farkas, N. Ruzickova, C. Flegel, N.H. Valencia, W. Mccutcheon, M. Malik, E.A. Aguilar, Npj Quantum Information 7 (2021).","mla":"Pivoluska, Matej, et al. “Semi-Device-Independent Random Number Generation with Flexible Assumptions.” Npj Quantum Information, vol. 7, 50, Springer Nature, 2021, doi:10.1038/s41534-021-00387-1.","apa":"Pivoluska, M., Plesch, M., Farkas, M., Ruzickova, N., Flegel, C., Valencia, N. H., … Aguilar, E. A. (2021). Semi-device-independent random number generation with flexible assumptions. Npj Quantum Information. Springer Nature. https://doi.org/10.1038/s41534-021-00387-1","ieee":"M. Pivoluska et al., “Semi-device-independent random number generation with flexible assumptions,” npj Quantum Information, vol. 7. Springer Nature, 2021.","ista":"Pivoluska M, Plesch M, Farkas M, Ruzickova N, Flegel C, Valencia NH, Mccutcheon W, Malik M, Aguilar EA. 2021. Semi-device-independent random number generation with flexible assumptions. npj Quantum Information. 7, 50.","ama":"Pivoluska M, Plesch M, Farkas M, et al. Semi-device-independent random number generation with flexible assumptions. npj Quantum Information. 2021;7. doi:10.1038/s41534-021-00387-1"},"article_type":"original","date_published":"2021-03-15T00:00:00Z","article_number":"50","file_date_updated":"2021-03-22T11:09:34Z","year":"2021","acknowledgement":"We would like to thank Robert Fickler for discussions about the experimental realization and Marek Sýs for running the NIST randomness test on the data we acquired in the experiment. We would like to thank Ugo Zanforlin, Gerald Buller, Daniel White, and Cristian Bonato for their help with the experiment. M. Pivoluska, M. Plesch, and M.M. acknowledge Czech-Austrian project MultiQUEST (I3053-N27 and GF17-33780L). M. Pivoluska and M. Plesch additionally acknowledge the support of VEGA project 2/0136/19. M.F. acknowledges support from the Polish NCN grant Sonata UMO-2014/14/E/ST2/00020, the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program ERC AdG CERQUTE (grant agreement No 834266), the State Research Agency (AEI) TRANQI (PID2019-106888GB-I00/10.13039/501100011033), the Government of Spain (FIS2020-TRANQI; Severo Ochoa CEX2019-000910-S), Fundació Cellex, Fundació Mir-Puig, and Generalitat de Catalunya (CERCA, AGAUR). M.M., W.M., N.H.V., and C.F. acknowledge support from the QuantERA ERA-NET Co-fund (FWF Project I3773-N36) and the UK Engineering and Physical Sciences Research Council (EPSRC) (EP/P024114/1).","publication_status":"published","publisher":"Springer Nature","department":[{"_id":"FyKo"}],"author":[{"full_name":"Pivoluska, Matej","first_name":"Matej","last_name":"Pivoluska"},{"last_name":"Plesch","first_name":"Martin","full_name":"Plesch, Martin"},{"full_name":"Farkas, Máté","last_name":"Farkas","first_name":"Máté"},{"full_name":"Ruzickova, Natalia","first_name":"Natalia","last_name":"Ruzickova","id":"D2761128-D73D-11E9-A1BF-BA0DE6697425"},{"full_name":"Flegel, Clara","last_name":"Flegel","first_name":"Clara"},{"full_name":"Valencia, Natalia Herrera","first_name":"Natalia Herrera","last_name":"Valencia"},{"full_name":"Mccutcheon, Will","first_name":"Will","last_name":"Mccutcheon"},{"last_name":"Malik","first_name":"Mehul","full_name":"Malik, Mehul"},{"full_name":"Aguilar, Edgar A.","last_name":"Aguilar","first_name":"Edgar A."}],"date_created":"2021-03-21T23:01:19Z","date_updated":"2023-08-07T14:17:26Z","volume":7,"month":"03","publication_identifier":{"eissn":["2056-6387"]},"external_id":{"isi":["000629173100001"]},"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"oa":1,"isi":1,"quality_controlled":"1","doi":"10.1038/s41534-021-00387-1","language":[{"iso":"eng"}]},{"day":"24","article_processing_charge":"No","has_accepted_license":"1","scopus_import":"1","date_published":"2020-02-24T00:00:00Z","article_type":"original","publication":"European Journal of Physics","citation":{"chicago":"Plesch, Martin, Samuel Plesník, and Natalia Ruzickova. “The IYPT and the ‘Ring Oiler’ Problem.” European Journal of Physics. IOP Publishing, 2020. https://doi.org/10.1088/1361-6404/ab6414.","mla":"Plesch, Martin, et al. “The IYPT and the ‘Ring Oiler’ Problem.” European Journal of Physics, vol. 41, no. 3, 034001, IOP Publishing, 2020, doi:10.1088/1361-6404/ab6414.","short":"M. Plesch, S. Plesník, N. Ruzickova, European Journal of Physics 41 (2020).","ista":"Plesch M, Plesník S, Ruzickova N. 2020. The IYPT and the ‘Ring Oiler’ problem. European Journal of Physics. 41(3), 034001.","apa":"Plesch, M., Plesník, S., & Ruzickova, N. (2020). The IYPT and the “Ring Oiler” problem. European Journal of Physics. IOP Publishing. https://doi.org/10.1088/1361-6404/ab6414","ieee":"M. Plesch, S. Plesník, and N. Ruzickova, “The IYPT and the ‘Ring Oiler’ problem,” European Journal of Physics, vol. 41, no. 3. IOP Publishing, 2020.","ama":"Plesch M, Plesník S, Ruzickova N. The IYPT and the “Ring Oiler” problem. European Journal of Physics. 2020;41(3). doi:10.1088/1361-6404/ab6414"},"abstract":[{"lang":"eng","text":"The International Young Physicists' Tournament (IYPT) continued in 2018 in Beijing, China and 2019 in Warsaw, Poland with its 31st and 32nd editions. The IYPT is a modern scientific competition for teams of high school students, also known as the Physics World Cup. It involves long-term theoretical and experimental work focused on solving 17 publicly announced open-ended problems in teams of five. On top of that, teams have to present their solutions in front of other teams and a scientific jury, and get opposed and reviewed by their peers. Here we present a brief information about the competition with a specific focus on one of the IYPT 2018 tasks, the 'Ring Oiler'. This seemingly simple mechanical problem appeared to be of such a complexity that even the dozens of participating teams and jurying scientists were not able to solve all of its subtleties."}],"issue":"3","type":"journal_article","file":[{"file_id":"7641","relation":"main_file","checksum":"47dda164e33b6c0c6c3ed14aad298376","date_updated":"2020-07-14T12:48:01Z","date_created":"2020-04-06T08:53:53Z","access_level":"open_access","file_name":"2020_EuropJourPhysics_Plesch.pdf","creator":"dernst","content_type":"application/pdf","file_size":1533672}],"oa_version":"Published Version","title":"The IYPT and the 'Ring Oiler' problem","ddc":["530"],"status":"public","intvolume":" 41","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","_id":"7622","month":"02","publication_identifier":{"issn":["01430807"],"eissn":["13616404"]},"language":[{"iso":"eng"}],"doi":"10.1088/1361-6404/ab6414","isi":1,"quality_controlled":"1","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"external_id":{"arxiv":["1910.03290"],"isi":["000537425400001"]},"oa":1,"file_date_updated":"2020-07-14T12:48:01Z","article_number":"034001","date_created":"2020-03-31T11:25:04Z","date_updated":"2023-08-18T10:18:29Z","volume":41,"author":[{"first_name":"Martin","last_name":"Plesch","full_name":"Plesch, Martin"},{"full_name":"Plesník, Samuel","last_name":"Plesník","first_name":"Samuel"},{"first_name":"Natalia","last_name":"Ruzickova","id":"D2761128-D73D-11E9-A1BF-BA0DE6697425","full_name":"Ruzickova, Natalia"}],"publication_status":"published","department":[{"_id":"FyKo"}],"publisher":"IOP Publishing","year":"2020"}]