---
OA_place: publisher
_id: '20357'
acknowledged_ssus:
- _id: ScienComp
- _id: E-Lib
acknowledgement: "I would also like to acknowledge the Austrian Academy of Sciences
for funding through the\r\nDOC Fellowship program (fellowship number 26917), the
Grants Office at ISTA for their\r\nassistance with the application, and the Scientific
Computing Unit for their support regarding\r\nhigh-performance computation.\r\n"
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Natalia
full_name: Ruzickova, Natalia
id: D2761128-D73D-11E9-A1BF-BA0DE6697425
last_name: Ruzickova
citation:
ama: Ruzickova N. Effect propagation in biological networks. 2025. doi:10.15479/AT-ISTA-20357
apa: Ruzickova, N. (2025). Effect propagation in biological networks. Institute
of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-20357
chicago: Ruzickova, Natalia. “Effect Propagation in Biological Networks.” Institute
of Science and Technology Austria, 2025. https://doi.org/10.15479/AT-ISTA-20357.
ieee: N. Ruzickova, “Effect propagation in biological networks,” Institute of Science
and Technology Austria, 2025.
ista: Ruzickova N. 2025. Effect propagation in biological networks. Institute of
Science and Technology Austria.
mla: Ruzickova, Natalia. Effect Propagation in Biological Networks. Institute
of Science and Technology Austria, 2025, doi:10.15479/AT-ISTA-20357.
short: N. Ruzickova, Effect Propagation in Biological Networks, Institute of Science
and Technology Austria, 2025.
corr_author: '1'
date_created: 2025-09-15T17:04:48Z
date_published: 2025-09-15T00:00:00Z
date_updated: 2026-04-07T12:02:39Z
day: '15'
ddc:
- '570'
- '530'
degree_awarded: PhD
department:
- _id: GradSch
- _id: GaTk
doi: 10.15479/AT-ISTA-20357
file:
- access_level: closed
checksum: 991e81bc16a76b4e0c352567728fd2c5
content_type: application/pdf
creator: nruzicko
date_created: 2025-09-16T12:56:06Z
date_updated: 2025-11-27T10:00:25Z
embargo: 2026-09-14
embargo_to: open_access
file_id: '20360'
file_name: 2025_Ruzickova_Natalia_Thesis.pdf
file_size: 43518367
relation: main_file
title: Effect propagation in biological networks
- access_level: closed
checksum: c4ab257adad116083d8a97fac69b2dde
content_type: application/zip
creator: nruzicko
date_created: 2025-09-16T12:59:23Z
date_updated: 2025-09-16T12:59:23Z
file_id: '20361'
file_name: 2025_Ruzickova_Natalia_Thesis_source.zip
file_size: 53464789
relation: source_file
file_date_updated: 2025-11-27T10:00:25Z
has_accepted_license: '1'
keyword:
- gene regulation
- networks
- omnigenic model
- pancreas
- collective behaviour
language:
- iso: eng
month: '09'
oa_version: Published Version
page: '160'
project:
- _id: 7bec9174-9f16-11ee-852c-ded9fe5f810e
name: Collective behaviour of cells in pancreatic Islets of Langerhans
publication_identifier:
isbn:
- 978-3-99078-066-4
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '18525'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Gašper
full_name: Tkačik, Gašper
id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
last_name: Tkačik
orcid: 0000-0002-6699-1455
title: Effect propagation in biological networks
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2025'
...
---
APC_amount: 1260 EUR
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '20664'
abstract:
- lang: eng
text: Conference travel contributes to the climate footprint of academic research.
Here, we provide a quantitative estimate of the carbon emissions associated with
conference attendance by analyzing travel data from participants of 10 international
conferences in the field of magnetic resonance, namely EUROMAR, ENC and ICMRBS.
We find that attending a EUROMAR conference produces, on average, more than 1 t CO2 eq..
For the analyzed conferences outside Europe, the corresponding value is about
2–3 times higher, on average, with intercontinental trips amounting to up to 5 t.
We compare these conference-related emissions to other activities associated with
research and show that conference travel is a substantial portion of the total
climate footprint of a researcher in magnetic resonance. We explore several strategies
to reduce these emissions, including the impact of selecting conference venues
more strategically and the possibility of decentralized conferences. Through a
detailed comparison of train versus air travel – accounting for both direct and
infrastructure-related emissions – we demonstrate that train travel offers considerable
carbon savings. These data may provide a basis for strategic choices of future
conferences in the field and for individuals deciding on their conference attendance.
acknowledgement: 'First and foremost, we are grateful to the conference organizers
who have provided data, either in the form of tables or by pointing us to abstract
books. We thank the reviewers and the handling editor (Gottfried Otting) for the
careful reading and suggestions. This project emerged from an interactive course
about energy and climate, held at IST Austria by Jeroen Dobbelaere, Georgios Katsaros
and Paul Schanda. We are grateful to ISTA''s Graduate School for enabling this interdisciplinary
course and to all participating students. We thank the following persons for discussions
and/or comments about the manuscript: Helene Van Melckebeke, Mei Hong, Jeff Hoch,
Gottfried Otting and Matthias Ernst. For the preparation of the manuscript, AI tools
have been used, namely for finding relevant literature (ChatGPT) and for correcting
the text (Writefull, within Overleaf LaTeX).'
article_processing_charge: Yes
article_type: original
author:
- first_name: Lucky
full_name: Kapoor, Lucky
id: 84b9700b-15b2-11ec-abd3-831089e67615
last_name: Kapoor
orcid: 0000-0001-8319-2148
- first_name: Natalia
full_name: Ruzickova, Natalia
id: D2761128-D73D-11E9-A1BF-BA0DE6697425
last_name: Ruzickova
- first_name: Predrag
full_name: Zivadinovic, Predrag
id: 68AA0E5A-AFDA-11E9-9994-141DE6697425
last_name: Zivadinovic
- first_name: Valentin
full_name: Leitner, Valentin
id: 4c665ce3-0016-11ec-bea0-e44de7a4fa3d
last_name: Leitner
- first_name: Maria A
full_name: Sisak, Maria A
id: 44A03D04-AEA4-11E9-B225-EA2DE6697425
last_name: Sisak
- first_name: Cecelia N
full_name: Mweka, Cecelia N
id: 2a69ab4b-896a-11ed-bdf8-cb8641cf2b21
last_name: Mweka
- first_name: Jeroen A
full_name: Dobbelaere, Jeroen A
id: c15a5412-de82-11ed-b809-8dc1aa996e40
last_name: Dobbelaere
- first_name: Georgios
full_name: Katsaros, Georgios
id: 38DB5788-F248-11E8-B48F-1D18A9856A87
last_name: Katsaros
orcid: 0000-0001-8342-202X
- first_name: Paul
full_name: Schanda, Paul
id: 7B541462-FAF6-11E9-A490-E8DFE5697425
last_name: Schanda
orcid: 0000-0002-9350-7606
citation:
ama: 'Kapoor L, Ruzickova N, Zivadinovic P, et al. Quantifying the carbon footprint
of conference travel: The case of NMR meetings. Magnetic Resonance. 2025;6(2):243-256.
doi:10.5194/mr-6-243-2025'
apa: 'Kapoor, L., Ruzickova, N., Zivadinovic, P., Leitner, V., Sisak, M. A., Mweka,
C. N., … Schanda, P. (2025). Quantifying the carbon footprint of conference travel:
The case of NMR meetings. Magnetic Resonance. Copernicus Publications.
https://doi.org/10.5194/mr-6-243-2025'
chicago: 'Kapoor, Lucky, Natalia Ruzickova, Predrag Zivadinovic, Valentin Leitner,
Maria A Sisak, Cecelia N Mweka, Jeroen A Dobbelaere, Georgios Katsaros, and Paul
Schanda. “Quantifying the Carbon Footprint of Conference Travel: The Case of NMR
Meetings.” Magnetic Resonance. Copernicus Publications, 2025. https://doi.org/10.5194/mr-6-243-2025.'
ieee: 'L. Kapoor et al., “Quantifying the carbon footprint of conference
travel: The case of NMR meetings,” Magnetic Resonance, vol. 6, no. 2. Copernicus
Publications, pp. 243–256, 2025.'
ista: 'Kapoor L, Ruzickova N, Zivadinovic P, Leitner V, Sisak MA, Mweka CN, Dobbelaere
JA, Katsaros G, Schanda P. 2025. Quantifying the carbon footprint of conference
travel: The case of NMR meetings. Magnetic Resonance. 6(2), 243–256.'
mla: 'Kapoor, Lucky, et al. “Quantifying the Carbon Footprint of Conference Travel:
The Case of NMR Meetings.” Magnetic Resonance, vol. 6, no. 2, Copernicus
Publications, 2025, pp. 243–56, doi:10.5194/mr-6-243-2025.'
short: L. Kapoor, N. Ruzickova, P. Zivadinovic, V. Leitner, M.A. Sisak, C.N. Mweka,
J.A. Dobbelaere, G. Katsaros, P. Schanda, Magnetic Resonance 6 (2025) 243–256.
corr_author: '1'
date_created: 2025-11-23T23:01:39Z
date_published: 2025-11-10T00:00:00Z
date_updated: 2026-06-10T08:45:11Z
day: '10'
ddc:
- '000'
department:
- _id: JoFi
- _id: GaTk
- _id: JoCs
- _id: EvBe
- _id: TaHa
- _id: GradSch
- _id: GeKa
- _id: PaSc
doi: 10.5194/mr-6-243-2025
file:
- access_level: open_access
checksum: c63dd47b0e77f9451821436bb77d27c9
content_type: application/pdf
creator: dernst
date_created: 2025-11-24T08:25:19Z
date_updated: 2025-11-24T08:25:19Z
file_id: '20672'
file_name: 2025_MagneticResonance_Kapoor.pdf
file_size: 3081399
relation: main_file
success: 1
file_date_updated: 2025-11-24T08:25:19Z
has_accepted_license: '1'
intvolume: ' 6'
issue: '2'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '11'
oa: 1
oa_version: Published Version
page: 243-256
project:
- _id: B67AFEDC-15C9-11EA-A837-991A96BB2854
name: IST Austria Open Access Fund
publication: Magnetic Resonance
publication_identifier:
eissn:
- 2699-0016
publication_status: published
publisher: Copernicus Publications
quality_controlled: '1'
related_material:
link:
- description: News on ISTA website
relation: research_data
url: https://ista.ac.at/en/news/carbon-footprint-of-conference-travel/
record:
- id: '20242'
relation: research_data
status: public
scopus_import: '1'
status: public
title: 'Quantifying the carbon footprint of conference travel: The case of NMR meetings'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 6
year: '2025'
...
---
APC_amount: 3062,93 EUR
OA_place: publisher
OA_type: hybrid
_id: '18525'
abstract:
- lang: eng
text: As their statistical power grows, genome-wide association studies (GWAS) have
identified an increasing number of loci underlying quantitative traits of interest.
These loci are scattered throughout the genome and are individually responsible
only for small fractions of the total heritable trait variance. The recently proposed
omnigenic model provides a conceptual framework to explain these observations
by postulating that numerous distant loci contribute to each complex trait via
effect propagation through intracellular regulatory networks. We formalize this
conceptual framework by proposing the “quantitative omnigenic model” (QOM), a
statistical model that combines prior knowledge of the regulatory network topology
with genomic data. By applying our model to gene expression traits in yeast, we
demonstrate that QOM achieves similar gene expression prediction performance to
traditional GWAS with hundreds of times less parameters, while simultaneously
extracting candidate causal and quantitative chains of effect propagation through
the regulatory network for every individual gene. We estimate the fraction of
heritable trait variance in cis- and in trans-, break the latter down by effect
propagation order, assess the trans- variance not attributable to transcriptional
regulation, and show that QOM correctly accounts for the low-dimensional structure
of gene expression covariance. We furthermore demonstrate the relevance of QOM
for systems biology, by employing it as a statistical test for the quality of
regulatory network reconstructions, and linking it to the propagation of nontranscriptional
(including environmental) effects.
acknowledgement: N.R.acknowledges the support of the Austrian Academy of Sciences
through the Doctoral Fellowship Programme (DOC) of the Austrian Academy of Sciences
26917. M.H. and G.T. were supported in part by the Human Frontiers Science Program
Grant RGP0034/2018. We thank Nicholas H. Barton, Fyodor Kondrashov, and Matthew
R. Robinson for fruitful discussions.
article_number: e2402340121
article_processing_charge: Yes
article_type: original
author:
- first_name: Natalia
full_name: Ruzickova, Natalia
id: D2761128-D73D-11E9-A1BF-BA0DE6697425
last_name: Ruzickova
- first_name: Michal
full_name: Hledik, Michal
id: 4171253A-F248-11E8-B48F-1D18A9856A87
last_name: Hledik
- first_name: Gašper
full_name: Tkačik, Gašper
id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
last_name: Tkačik
orcid: 0000-0002-6699-1455
citation:
ama: Ruzickova N, Hledik M, Tkačik G. Quantitative omnigenic model discovers interpretable
genome-wide associations. Proceedings of the National Academy of Sciences of
the United States of America. 2024;121(44). doi:10.1073/pnas.2402340121
apa: Ruzickova, N., Hledik, M., & Tkačik, G. (2024). Quantitative omnigenic
model discovers interpretable genome-wide associations. Proceedings of the
National Academy of Sciences of the United States of America. National Academy
of Sciences. https://doi.org/10.1073/pnas.2402340121
chicago: Ruzickova, Natalia, Michal Hledik, and Gašper Tkačik. “Quantitative Omnigenic
Model Discovers Interpretable Genome-Wide Associations.” Proceedings of the
National Academy of Sciences of the United States of America. National Academy
of Sciences, 2024. https://doi.org/10.1073/pnas.2402340121.
ieee: N. Ruzickova, M. Hledik, and G. Tkačik, “Quantitative omnigenic model discovers
interpretable genome-wide associations,” Proceedings of the National Academy
of Sciences of the United States of America, vol. 121, no. 44. National Academy
of Sciences, 2024.
ista: Ruzickova N, Hledik M, Tkačik G. 2024. Quantitative omnigenic model discovers
interpretable genome-wide associations. Proceedings of the National Academy of
Sciences of the United States of America. 121(44), e2402340121.
mla: Ruzickova, Natalia, et al. “Quantitative Omnigenic Model Discovers Interpretable
Genome-Wide Associations.” Proceedings of the National Academy of Sciences
of the United States of America, vol. 121, no. 44, e2402340121, National Academy
of Sciences, 2024, doi:10.1073/pnas.2402340121.
short: N. Ruzickova, M. Hledik, G. Tkačik, Proceedings of the National Academy of
Sciences of the United States of America 121 (2024).
corr_author: '1'
date_created: 2024-11-10T23:01:59Z
date_published: 2024-10-29T00:00:00Z
date_updated: 2026-04-07T12:02:39Z
day: '29'
ddc:
- '570'
department:
- _id: GaTk
- _id: NiBa
doi: 10.1073/pnas.2402340121
external_id:
isi:
- '001349462600001'
pmid:
- '39441639'
file:
- access_level: open_access
checksum: d930e2ccf9ec900c7d7509a78cfb3564
content_type: application/pdf
creator: dernst
date_created: 2024-11-11T09:31:00Z
date_updated: 2024-11-11T09:31:00Z
file_id: '18536'
file_name: 2024_PNAS_Ruzickova.pdf
file_size: 25529709
relation: main_file
success: 1
file_date_updated: 2024-11-11T09:31:00Z
has_accepted_license: '1'
intvolume: ' 121'
isi: 1
issue: '44'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '10'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 7bec9174-9f16-11ee-852c-ded9fe5f810e
name: Collective behaviour of cells in pancreatic Islets of Langerhans
- _id: 2665AAFE-B435-11E9-9278-68D0E5697425
grant_number: RGP0034/2018
name: Can evolution minimize spurious signaling crosstalk to reach optimal performance?
publication: Proceedings of the National Academy of Sciences of the United States
of America
publication_identifier:
eissn:
- 1091-6490
issn:
- 0027-8424
publication_status: published
publisher: National Academy of Sciences
quality_controlled: '1'
related_material:
record:
- id: '20357'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Quantitative omnigenic model discovers interpretable genome-wide associations
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 121
year: '2024'
...
---
_id: '9255'
abstract:
- lang: eng
text: Our ability to trust that a random number is truly random is essential for
fields as diverse as cryptography and fundamental tests of quantum mechanics.
Existing solutions both come with drawbacks—device-independent quantum random
number generators (QRNGs) are highly impractical and standard semi-device-independent
QRNGs are limited to a specific physical implementation and level of trust. Here
we propose a framework for semi-device-independent randomness certification, using
a source of trusted vacuum in the form of a signal shutter. It employs a flexible
set of assumptions and levels of trust, allowing it to be applied in a wide range
of physical scenarios involving both quantum and classical entropy sources. We
experimentally demonstrate our protocol with a photonic setup and generate secure
random bits under three different assumptions with varying degrees of security
and resulting data rates.
acknowledgement: We would like to thank Robert Fickler for discussions about the experimental
realization and Marek Sýs for running the NIST randomness test on the data we acquired
in the experiment. We would like to thank Ugo Zanforlin, Gerald Buller, Daniel White,
and Cristian Bonato for their help with the experiment. M. Pivoluska, M. Plesch,
and M.M. acknowledge Czech-Austrian project MultiQUEST (I3053-N27 and GF17-33780L).
M. Pivoluska and M. Plesch additionally acknowledge the support of VEGA project
2/0136/19. M.F. acknowledges support from the Polish NCN grant Sonata UMO-2014/14/E/ST2/00020,
the European Research Council (ERC) under the European Union’s Horizon 2020 research
and innovation program ERC AdG CERQUTE (grant agreement No 834266), the State Research
Agency (AEI) TRANQI (PID2019-106888GB-I00/10.13039/501100011033), the Government
of Spain (FIS2020-TRANQI; Severo Ochoa CEX2019-000910-S), Fundació Cellex, Fundació
Mir-Puig, and Generalitat de Catalunya (CERCA, AGAUR). M.M., W.M., N.H.V., and C.F.
acknowledge support from the QuantERA ERA-NET Co-fund (FWF Project I3773-N36) and
the UK Engineering and Physical Sciences Research Council (EPSRC) (EP/P024114/1).
article_number: '50'
article_processing_charge: No
article_type: original
author:
- first_name: Matej
full_name: Pivoluska, Matej
last_name: Pivoluska
- first_name: Martin
full_name: Plesch, Martin
last_name: Plesch
- first_name: Máté
full_name: Farkas, Máté
last_name: Farkas
- first_name: Natalia
full_name: Ruzickova, Natalia
id: D2761128-D73D-11E9-A1BF-BA0DE6697425
last_name: Ruzickova
- first_name: Clara
full_name: Flegel, Clara
last_name: Flegel
- first_name: Natalia Herrera
full_name: Valencia, Natalia Herrera
last_name: Valencia
- first_name: Will
full_name: Mccutcheon, Will
last_name: Mccutcheon
- first_name: Mehul
full_name: Malik, Mehul
last_name: Malik
- first_name: Edgar A.
full_name: Aguilar, Edgar A.
last_name: Aguilar
citation:
ama: Pivoluska M, Plesch M, Farkas M, et al. Semi-device-independent random number
generation with flexible assumptions. npj Quantum Information. 2021;7.
doi:10.1038/s41534-021-00387-1
apa: Pivoluska, M., Plesch, M., Farkas, M., Ruzickova, N., Flegel, C., Valencia,
N. H., … Aguilar, E. A. (2021). Semi-device-independent random number generation
with flexible assumptions. Npj Quantum Information. Springer Nature. https://doi.org/10.1038/s41534-021-00387-1
chicago: Pivoluska, Matej, Martin Plesch, Máté Farkas, Natalia Ruzickova, Clara
Flegel, Natalia Herrera Valencia, Will Mccutcheon, Mehul Malik, and Edgar A. Aguilar.
“Semi-Device-Independent Random Number Generation with Flexible Assumptions.”
Npj Quantum Information. Springer Nature, 2021. https://doi.org/10.1038/s41534-021-00387-1.
ieee: M. Pivoluska et al., “Semi-device-independent random number generation
with flexible assumptions,” npj Quantum Information, vol. 7. Springer Nature,
2021.
ista: Pivoluska M, Plesch M, Farkas M, Ruzickova N, Flegel C, Valencia NH, Mccutcheon
W, Malik M, Aguilar EA. 2021. Semi-device-independent random number generation
with flexible assumptions. npj Quantum Information. 7, 50.
mla: Pivoluska, Matej, et al. “Semi-Device-Independent Random Number Generation
with Flexible Assumptions.” Npj Quantum Information, vol. 7, 50, Springer
Nature, 2021, doi:10.1038/s41534-021-00387-1.
short: M. Pivoluska, M. Plesch, M. Farkas, N. Ruzickova, C. Flegel, N.H. Valencia,
W. Mccutcheon, M. Malik, E.A. Aguilar, Npj Quantum Information 7 (2021).
date_created: 2021-03-21T23:01:19Z
date_published: 2021-03-15T00:00:00Z
date_updated: 2023-08-07T14:17:26Z
day: '15'
ddc:
- '530'
department:
- _id: FyKo
doi: 10.1038/s41534-021-00387-1
external_id:
isi:
- '000629173100001'
file:
- access_level: open_access
checksum: 26d3f2a2c8c8fa8c1002028326b45f64
content_type: application/pdf
creator: dernst
date_created: 2021-03-22T11:09:34Z
date_updated: 2021-03-22T11:09:34Z
file_id: '9274'
file_name: 2021_NPJQuantumInformation_Pivoluska.pdf
file_size: 1360271
relation: main_file
success: 1
file_date_updated: 2021-03-22T11:09:34Z
has_accepted_license: '1'
intvolume: ' 7'
isi: 1
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
publication: npj Quantum Information
publication_identifier:
eissn:
- 2056-6387
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Semi-device-independent random number generation with flexible assumptions
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 7
year: '2021'
...
---
_id: '8602'
abstract:
- lang: eng
text: Collective cell migration offers a rich field of study for non-equilibrium
physics and cellular biology, revealing phenomena such as glassy dynamics, pattern
formation and active turbulence. However, how mechanical and chemical signalling
are integrated at the cellular level to give rise to such collective behaviours
remains unclear. We address this by focusing on the highly conserved phenomenon
of spatiotemporal waves of density and extracellular signal-regulated kinase (ERK)
activation, which appear both in vitro and in vivo during collective cell migration
and wound healing. First, we propose a biophysical theory, backed by mechanical
and optogenetic perturbation experiments, showing that patterns can be quantitatively
explained by a mechanochemical coupling between active cellular tensions and the
mechanosensitive ERK pathway. Next, we demonstrate how this biophysical mechanism
can robustly induce long-ranged order and migration in a desired orientation,
and we determine the theoretically optimal wavelength and period for inducing
maximal migration towards free edges, which fits well with experimentally observed
dynamics. We thereby provide a bridge between the biophysical origin of spatiotemporal
instabilities and the design principles of robust and efficient long-ranged migration.
acknowledgement: We would like to thank G. Tkacik and all of the members of the Hannezo
and Hirashima groups for useful discussions, X. Trepat for help on traction force
microscopy and M. Matsuda for use of the lab facility. E.H. acknowledges grants
from the Austrian Science Fund (FWF) (P 31639) and the European Research Council
(851288). T.H. acknowledges a grant from JST, PRESTO (JPMJPR1949). This project
has received funding from the European Union’s Horizon 2020 research and innovation
programme under the Marie Skłodowska-Curie grant agreement no. 665385 (to D.B.),
from JSPS KAKENHI grant no. 17J02107 (to N.H.) and from the SPIRITS 2018 of Kyoto
University (to E.H. and T.H.).
article_processing_charge: No
article_type: original
author:
- first_name: Daniel R
full_name: Boocock, Daniel R
id: 453AF628-F248-11E8-B48F-1D18A9856A87
last_name: Boocock
orcid: 0000-0002-1585-2631
- first_name: Naoya
full_name: Hino, Naoya
last_name: Hino
- first_name: Natalia
full_name: Ruzickova, Natalia
id: D2761128-D73D-11E9-A1BF-BA0DE6697425
last_name: Ruzickova
- first_name: Tsuyoshi
full_name: Hirashima, Tsuyoshi
last_name: Hirashima
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
citation:
ama: Boocock DR, Hino N, Ruzickova N, Hirashima T, Hannezo EB. Theory of mechanochemical
patterning and optimal migration in cell monolayers. Nature Physics. 2021;17:267-274.
doi:10.1038/s41567-020-01037-7
apa: Boocock, D. R., Hino, N., Ruzickova, N., Hirashima, T., & Hannezo, E. B.
(2021). Theory of mechanochemical patterning and optimal migration in cell monolayers.
Nature Physics. Springer Nature. https://doi.org/10.1038/s41567-020-01037-7
chicago: Boocock, Daniel R, Naoya Hino, Natalia Ruzickova, Tsuyoshi Hirashima, and
Edouard B Hannezo. “Theory of Mechanochemical Patterning and Optimal Migration
in Cell Monolayers.” Nature Physics. Springer Nature, 2021. https://doi.org/10.1038/s41567-020-01037-7.
ieee: D. R. Boocock, N. Hino, N. Ruzickova, T. Hirashima, and E. B. Hannezo, “Theory
of mechanochemical patterning and optimal migration in cell monolayers,” Nature
Physics, vol. 17. Springer Nature, pp. 267–274, 2021.
ista: Boocock DR, Hino N, Ruzickova N, Hirashima T, Hannezo EB. 2021. Theory of
mechanochemical patterning and optimal migration in cell monolayers. Nature Physics.
17, 267–274.
mla: Boocock, Daniel R., et al. “Theory of Mechanochemical Patterning and Optimal
Migration in Cell Monolayers.” Nature Physics, vol. 17, Springer Nature,
2021, pp. 267–74, doi:10.1038/s41567-020-01037-7.
short: D.R. Boocock, N. Hino, N. Ruzickova, T. Hirashima, E.B. Hannezo, Nature Physics
17 (2021) 267–274.
corr_author: '1'
date_created: 2020-10-04T22:01:37Z
date_published: 2021-02-01T00:00:00Z
date_updated: 2026-06-21T22:30:11Z
day: '01'
department:
- _id: EdHa
doi: 10.1038/s41567-020-01037-7
ec_funded: 1
external_id:
isi:
- '000573519500002'
intvolume: ' 17'
isi: 1
language:
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url: https://doi.org/10.1101/2020.05.15.096479
month: '02'
oa: 1
oa_version: Preprint
page: 267-274
project:
- _id: 268294B6-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P31639
name: Active mechano-chemical description of the cell cytoskeleton
- _id: 05943252-7A3F-11EA-A408-12923DDC885E
call_identifier: H2020
grant_number: '851288'
name: Design Principles of Branching Morphogenesis
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication: Nature Physics
publication_identifier:
eissn:
- 1745-2481
issn:
- 1745-2473
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/wound-healing-waves/
record:
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status: public
scopus_import: '1'
status: public
title: Theory of mechanochemical patterning and optimal migration in cell monolayers
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2021'
...
---
_id: '7622'
abstract:
- lang: eng
text: The International Young Physicists' Tournament (IYPT) continued in 2018 in
Beijing, China and 2019 in Warsaw, Poland with its 31st and 32nd editions. The
IYPT is a modern scientific competition for teams of high school students, also
known as the Physics World Cup. It involves long-term theoretical and experimental
work focused on solving 17 publicly announced open-ended problems in teams of
five. On top of that, teams have to present their solutions in front of other
teams and a scientific jury, and get opposed and reviewed by their peers. Here
we present a brief information about the competition with a specific focus on
one of the IYPT 2018 tasks, the 'Ring Oiler'. This seemingly simple mechanical
problem appeared to be of such a complexity that even the dozens of participating
teams and jurying scientists were not able to solve all of its subtleties.
article_number: '034001'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Martin
full_name: Plesch, Martin
last_name: Plesch
- first_name: Samuel
full_name: Plesník, Samuel
last_name: Plesník
- first_name: Natalia
full_name: Ruzickova, Natalia
id: D2761128-D73D-11E9-A1BF-BA0DE6697425
last_name: Ruzickova
citation:
ama: Plesch M, Plesník S, Ruzickova N. The IYPT and the “Ring Oiler” problem. European
Journal of Physics. 2020;41(3). doi:10.1088/1361-6404/ab6414
apa: Plesch, M., Plesník, S., & Ruzickova, N. (2020). The IYPT and the “Ring
Oiler” problem. European Journal of Physics. IOP Publishing. https://doi.org/10.1088/1361-6404/ab6414
chicago: Plesch, Martin, Samuel Plesník, and Natalia Ruzickova. “The IYPT and the
‘Ring Oiler’ Problem.” European Journal of Physics. IOP Publishing, 2020.
https://doi.org/10.1088/1361-6404/ab6414.
ieee: M. Plesch, S. Plesník, and N. Ruzickova, “The IYPT and the ‘Ring Oiler’ problem,”
European Journal of Physics, vol. 41, no. 3. IOP Publishing, 2020.
ista: Plesch M, Plesník S, Ruzickova N. 2020. The IYPT and the ‘Ring Oiler’ problem.
European Journal of Physics. 41(3), 034001.
mla: Plesch, Martin, et al. “The IYPT and the ‘Ring Oiler’ Problem.” European
Journal of Physics, vol. 41, no. 3, 034001, IOP Publishing, 2020, doi:10.1088/1361-6404/ab6414.
short: M. Plesch, S. Plesník, N. Ruzickova, European Journal of Physics 41 (2020).
date_created: 2020-03-31T11:25:04Z
date_published: 2020-02-24T00:00:00Z
date_updated: 2026-04-02T14:22:29Z
day: '24'
ddc:
- '530'
department:
- _id: FyKo
doi: 10.1088/1361-6404/ab6414
external_id:
arxiv:
- '1910.03290'
isi:
- '000537425400001'
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checksum: 47dda164e33b6c0c6c3ed14aad298376
content_type: application/pdf
creator: dernst
date_created: 2020-04-06T08:53:53Z
date_updated: 2020-07-14T12:48:01Z
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file_name: 2020_EuropJourPhysics_Plesch.pdf
file_size: 1533672
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file_date_updated: 2020-07-14T12:48:01Z
has_accepted_license: '1'
intvolume: ' 41'
isi: 1
issue: '3'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
publication: European Journal of Physics
publication_identifier:
eissn:
- 1361-6404
issn:
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publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: The IYPT and the 'Ring Oiler' problem
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 41
year: '2020'
...