---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21746'
abstract:
- lang: eng
  text: As vertebrates transitioned from water to land, locomotion shifted from undulatory
    swimming to limb-based movement. How spinal circuits and their cell types evolved
    to support this transition remains unclear. We leverage frog metamorphosis, which
    recapitulates this transition within a single organism, to define how spinal circuits
    generate aquatic versus terrestrial motor patterns. At swim stages, spinal architecture
    is uniform, with a transcriptionally and anatomically homogeneous motor and interneurons.
    As limbs develop and their movement complexifies, spinal circuits expand in neuron
    number and subtype diversity. This expansion is most pronounced for V1 inhibitory
    neurons, which increase ∼70-fold and diversify into transcriptionally distinct
    subtypes. Disrupting transcription factors defining emerging motor and V1 populations
    reveals molecular segregation between swim and limb circuits, highlighting the
    role of subtype diversity in motor coordination. A multifold increase in inhibitory
    neuron diversity thus underlies the tail-to-limb locomotor transition, providing
    a framework for spinal circuit adaptation during vertebrate evolution.
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
acknowledgement: 'We would like to thank the members of the Sweeney Lab, Mario de
  Bono, Michael Forsthofer, Katharina Lust, and Meital Oren, for comments on the manuscript.
  We are also grateful to Tom Jessell and Chris Kintner for their scientific insight
  and mentorship during the conception of this project. It would also have not been
  possible without the technical support of the Aquatics and Imaging and Optics Facility
  support teams (ISTA). We thank Martin Estermann for preparing the initial draft
  of the graphical abstract and Niki Barolini for the final version. In addition,
  we thank our funding sources for providing the resources to do these experiments:
  GFF NÖ FTI Strategy Lower Austria dissertation grant FT121-D-046 (to D.V.), Horizon
  Europe ERC starting grant 101041551 (to Y.I., L.B.S., F.A.T., and D.V.), Special
  Research Program (SFB) of the Austrian Science Fund (FWF) project F7814-B (to L.B.S.),
  Austrian Science Fund (FWF) 10.55776/COE16 (to Y.I. and L.B.S.), NINDS 5R35NS116858
  (to J.S.D.), CZI grant DAF2020-225401 (DOI) 10.37921/120055ratwvi (to R.H.), NIH
  grant R01NS123116 (to J.B.B.), American Lebanese Syrian Associated Charities (ALSAC)
  (to J.B.B.), German Academic Exchange Service (DAAD) IFI grant 57515251-91853472
  (to Z.H.), and Project A.L.S. (to S.B.-M.).'
article_number: '117227'
article_processing_charge: Yes
article_type: original
author:
- first_name: David
  full_name: Vijatovic, David
  id: cf391e77-ec3c-11ea-a124-d69323410b58
  last_name: Vijatovic
- first_name: 'Florina Alexandra '
  full_name: 'Toma, Florina Alexandra '
  id: 2f73f876-f128-11eb-9611-b96b5a30cb0e
  last_name: Toma
- first_name: Y
  full_name: Ignatyev, Y
  last_name: Ignatyev
- first_name: Zoe P
  full_name: Harrington, Zoe P
  id: a8144562-32c9-11ee-b5ce-d9800628bda2
  last_name: Harrington
  orcid: 0009-0008-0158-4032
- first_name: Christoph M
  full_name: Sommer, Christoph M
  id: 4DF26D8C-F248-11E8-B48F-1D18A9856A87
  last_name: Sommer
  orcid: 0000-0003-1216-9105
- first_name: Robert
  full_name: Hauschild, Robert
  id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87
  last_name: Hauschild
  orcid: 0000-0001-9843-3522
- first_name: Matthijs Geert
  full_name: Smits, Matthijs Geert
  id: 7a231d52-e216-11ee-a0bb-8acd55f8f1f0
  last_name: Smits
- first_name: Marco
  full_name: Dalla Vecchia, Marco
  id: 02a7a869-ff06-11ed-a87f-86649d6077e5
  last_name: Dalla Vecchia
- first_name: Alexandra J.
  full_name: Trevisan, Alexandra J.
  last_name: Trevisan
- first_name: Phillip
  full_name: Chapman, Phillip
  last_name: Chapman
- first_name: Mara
  full_name: Julseth, Mara
  id: 1cf464b2-dc7d-11ea-9b2f-f9b1aa9417d1
  last_name: Julseth
- first_name: Susan
  full_name: Brenner-Morton, Susan
  last_name: Brenner-Morton
- first_name: Mariano I.
  full_name: Gabitto, Mariano I.
  last_name: Gabitto
- first_name: Jeremy S.
  full_name: Dasen, Jeremy S.
  last_name: Dasen
- first_name: Jay B.
  full_name: Bikoff, Jay B.
  last_name: Bikoff
- first_name: Lora Beatrice Jaeger
  full_name: Sweeney, Lora Beatrice Jaeger
  id: 56BE8254-C4F0-11E9-8E45-0B23E6697425
  last_name: Sweeney
  orcid: 0000-0001-9242-5601
citation:
  ama: Vijatovic D, Toma FA, Ignatyev Y, et al. Multifold increase in spinal inhibitory
    cell types with emergence of limb movement. <i>Cell Reports</i>. 2026;45(4). doi:<a
    href="https://doi.org/10.1016/j.celrep.2026.117227">10.1016/j.celrep.2026.117227</a>
  apa: Vijatovic, D., Toma, F. A., Ignatyev, Y., Harrington, Z. P., Sommer, C. M.,
    Hauschild, R., … Sweeney, L. B. (2026). Multifold increase in spinal inhibitory
    cell types with emergence of limb movement. <i>Cell Reports</i>. Elsevier. <a
    href="https://doi.org/10.1016/j.celrep.2026.117227">https://doi.org/10.1016/j.celrep.2026.117227</a>
  chicago: Vijatovic, David, Florina Alexandra  Toma, Y Ignatyev, Zoe P Harrington,
    Christoph M Sommer, Robert Hauschild, Matthijs Geert Smits, et al. “Multifold
    Increase in Spinal Inhibitory Cell Types with Emergence of Limb Movement.” <i>Cell
    Reports</i>. Elsevier, 2026. <a href="https://doi.org/10.1016/j.celrep.2026.117227">https://doi.org/10.1016/j.celrep.2026.117227</a>.
  ieee: D. Vijatovic <i>et al.</i>, “Multifold increase in spinal inhibitory cell
    types with emergence of limb movement,” <i>Cell Reports</i>, vol. 45, no. 4. Elsevier,
    2026.
  ista: Vijatovic D, Toma FA, Ignatyev Y, Harrington ZP, Sommer CM, Hauschild R, Smits
    MG, Dalla Vecchia M, Trevisan AJ, Chapman P, Julseth M, Brenner-Morton S, Gabitto
    MI, Dasen JS, Bikoff JB, Sweeney LB. 2026. Multifold increase in spinal inhibitory
    cell types with emergence of limb movement. Cell Reports. 45(4), 117227.
  mla: Vijatovic, David, et al. “Multifold Increase in Spinal Inhibitory Cell Types
    with Emergence of Limb Movement.” <i>Cell Reports</i>, vol. 45, no. 4, 117227,
    Elsevier, 2026, doi:<a href="https://doi.org/10.1016/j.celrep.2026.117227">10.1016/j.celrep.2026.117227</a>.
  short: D. Vijatovic, F.A. Toma, Y. Ignatyev, Z.P. Harrington, C.M. Sommer, R. Hauschild,
    M.G. Smits, M. Dalla Vecchia, A.J. Trevisan, P. Chapman, M. Julseth, S. Brenner-Morton,
    M.I. Gabitto, J.S. Dasen, J.B. Bikoff, L.B. Sweeney, Cell Reports 45 (2026).
corr_author: '1'
date_created: 2026-04-19T22:07:43Z
date_published: 2026-04-28T00:00:00Z
date_updated: 2026-05-04T12:27:06Z
day: '28'
ddc:
- '570'
department:
- _id: LoSw
- _id: GradSch
- _id: TiVo
- _id: Bio
- _id: NiBa
doi: 10.1016/j.celrep.2026.117227
external_id:
  pmid:
  - '41964955 '
file:
- access_level: open_access
  checksum: 0d26cdb5b8d8dec3a911d8261a65cdef
  content_type: application/pdf
  creator: dernst
  date_created: 2026-05-04T12:20:10Z
  date_updated: 2026-05-04T12:20:10Z
  file_id: '21795'
  file_name: 2026_CellReports_Vijatovic.pdf
  file_size: 14925958
  relation: main_file
  success: 1
file_date_updated: 2026-05-04T12:20:10Z
has_accepted_license: '1'
intvolume: '        45'
issue: '4'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: ebb66355-77a9-11ec-83b8-b8ac210a4dae
  grant_number: '101041551'
  name: Development and Evolution of Tetrapod Motor Circuits
- _id: 8da85f50-16d5-11f0-9cad-eab8b0ff6c9e
  grant_number: F7814
  name: 'Stem Cell Modulation in Neural Development and Regeneration/ P14-Swim-to-limb
    transition: cell type to connection diversity'
- _id: c08e9ad1-5a5b-11eb-8a69-9d1cf3b07473
  grant_number: CZI01
  name: Tools for automation and feedback microscopy
- _id: bd73af52-d553-11ed-ba76-912049f0ac7a
  grant_number: FTI21-D-046
  name: Development of V1 interneuron diversity during swim-to-walk transition of
    Xenopus metamorphosis
publication: Cell Reports
publication_identifier:
  eissn:
  - 2211-1247
  issn:
  - 2639-1856
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Multifold increase in spinal inhibitory cell types with emergence of limb movement
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 45
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
_id: '15016'
abstract:
- lang: eng
  text: Amphibians, by virtue of their phylogenetic position, provide invaluable insights
    on nervous system evolution, development, and remodeling. The genetic toolkit
    for amphibians, however, remains limited. Recombinant adeno-associated viral vectors
    (AAVs) are a powerful alternative to transgenesis for labeling and manipulating
    neurons. Although successful in mammals, AAVs have never been shown to transduce
    amphibian cells efficiently. We screened AAVs in three amphibian species—the frogs
    Xenopus laevis and Pelophylax bedriagae and the salamander Pleurodeles waltl—and
    identified at least two AAV serotypes per species that transduce neurons. In developing
    amphibians, AAVs labeled groups of neurons generated at the same time during development.
    In the mature brain, AAVrg retrogradely traced long-range projections. Our study
    introduces AAVs as a tool for amphibian research, establishes a generalizable
    workflow for AAV screening in new species, and expands opportunities for cross-species
    comparisons of nervous system development, function, and evolution.
acknowledged_ssus:
- _id: PreCl
- _id: Bio
acknowledgement: 'We thank members of the Sweeney, Tosches, Shein-Idelson, Yamaguchi,
  Kelley, and Cline Labs for their contributions to this project, discussion, and
  support. We additionally thank the Beckman Institute CLOVER Center and Viviana Gradinaru
  (Caltech), Kimberly Ritola (UNC NeuroTools), and Flavia Gomez-Leite (ISTA Viral
  Core) for AAV production and consultation; Andras Simon and Alberto Joven (Karolinska
  Institute) for feedback; Elizabeth Bagnato-Cohen (Columbia) for project coordination;
  our animal care and imaging facilities; the amphibian stock centers (NXR, EXRC,
  and XenopusExpress); and our funding sources: NSF IOS 2110086 (D.B.K., L.B.S., M.A.T.,
  A.Y., and H.T.C.); US-Israel Binational Science Foundation (BSF) 2020702 (M.S.-I.);
  FTI Strategy Lower Austria Dissertation FT121-D-046 (D.V.); Horizon Europe ERC Starting
  Grant 101041551 and Special Research Programme (SFB) of the Austrian Science Fund
  (FWF) project F7814-B (L.B.S.); NIH grant R35GM146973, Rita Allen Foundation Award
  GA_032522_FE, and CZI Ben Barres Early Career Acceleration Award 2023-331758 (M.A.T.);
  EMBO Long-Term Fellowship ALTF 874-2021 (A.D.); and NSF GRFP DGE 2036197 (E.C.B.J.).'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Eliza C.B.
  full_name: Jaeger, Eliza C.B.
  last_name: Jaeger
- first_name: David
  full_name: Vijatovic, David
  id: cf391e77-ec3c-11ea-a124-d69323410b58
  last_name: Vijatovic
- first_name: Astrid
  full_name: Deryckere, Astrid
  last_name: Deryckere
- first_name: Nikol
  full_name: Zorin, Nikol
  last_name: Zorin
- first_name: Akemi L.
  full_name: Nguyen, Akemi L.
  last_name: Nguyen
- first_name: Georgiy
  full_name: Ivanian, Georgiy
  id: eaf2b366-cfd1-11ee-bbdf-c8790f800a05
  last_name: Ivanian
- first_name: Jamie
  full_name: Woych, Jamie
  last_name: Woych
- first_name: Rebecca C
  full_name: Arnold, Rebecca C
  id: d6cce458-14c9-11ed-a755-c1c8fc6fde6f
  last_name: Arnold
- first_name: Alonso
  full_name: Ortega Gurrola, Alonso
  last_name: Ortega Gurrola
- first_name: Arik
  full_name: Shvartsman, Arik
  last_name: Shvartsman
- first_name: Francesca
  full_name: Barbieri, Francesca
  id: a9492887-8972-11ed-ae7b-bfae10998254
  last_name: Barbieri
- first_name: Florina-Alexandra
  full_name: Toma, Florina-Alexandra
  id: 85dd99f2-15b2-11ec-abd3-d1ae4d57f3b5
  last_name: Toma
- first_name: Gary J.
  full_name: Gorbsky, Gary J.
  last_name: Gorbsky
- first_name: Marko E.
  full_name: Horb, Marko E.
  last_name: Horb
- first_name: Hollis T.
  full_name: Cline, Hollis T.
  last_name: Cline
- first_name: Timothy F.
  full_name: Shay, Timothy F.
  last_name: Shay
- first_name: Darcy B.
  full_name: Kelley, Darcy B.
  last_name: Kelley
- first_name: Ayako
  full_name: Yamaguchi, Ayako
  last_name: Yamaguchi
- first_name: Mark
  full_name: Shein-Idelson, Mark
  last_name: Shein-Idelson
- first_name: Maria Antonietta
  full_name: Tosches, Maria Antonietta
  last_name: Tosches
- first_name: Lora Beatrice Jaeger
  full_name: Sweeney, Lora Beatrice Jaeger
  id: 56BE8254-C4F0-11E9-8E45-0B23E6697425
  last_name: Sweeney
  orcid: 0000-0001-9242-5601
citation:
  ama: Jaeger ECB, Vijatovic D, Deryckere A, et al. Adeno-associated viral tools to
    trace neural development and connectivity across amphibians. <i>Developmental
    Cell</i>. 2025;60(5):794-812.e6. doi:<a href="https://doi.org/10.1016/j.devcel.2024.10.025">10.1016/j.devcel.2024.10.025</a>
  apa: Jaeger, E. C. B., Vijatovic, D., Deryckere, A., Zorin, N., Nguyen, A. L., Ivanian,
    G., … Sweeney, L. B. (2025). Adeno-associated viral tools to trace neural development
    and connectivity across amphibians. <i>Developmental Cell</i>. Elsevier. <a href="https://doi.org/10.1016/j.devcel.2024.10.025">https://doi.org/10.1016/j.devcel.2024.10.025</a>
  chicago: Jaeger, Eliza C.B., David Vijatovic, Astrid Deryckere, Nikol Zorin, Akemi
    L. Nguyen, Georgiy Ivanian, Jamie Woych, et al. “Adeno-Associated Viral Tools
    to Trace Neural Development and Connectivity across Amphibians.” <i>Developmental
    Cell</i>. Elsevier, 2025. <a href="https://doi.org/10.1016/j.devcel.2024.10.025">https://doi.org/10.1016/j.devcel.2024.10.025</a>.
  ieee: E. C. B. Jaeger <i>et al.</i>, “Adeno-associated viral tools to trace neural
    development and connectivity across amphibians,” <i>Developmental Cell</i>, vol.
    60, no. 5. Elsevier, p. 794–812.e6, 2025.
  ista: Jaeger ECB, Vijatovic D, Deryckere A, Zorin N, Nguyen AL, Ivanian G, Woych
    J, Arnold RC, Ortega Gurrola A, Shvartsman A, Barbieri F, Toma F-A, Gorbsky GJ,
    Horb ME, Cline HT, Shay TF, Kelley DB, Yamaguchi A, Shein-Idelson M, Tosches MA,
    Sweeney LB. 2025. Adeno-associated viral tools to trace neural development and
    connectivity across amphibians. Developmental Cell. 60(5), 794–812.e6.
  mla: Jaeger, Eliza C. B., et al. “Adeno-Associated Viral Tools to Trace Neural Development
    and Connectivity across Amphibians.” <i>Developmental Cell</i>, vol. 60, no. 5,
    Elsevier, 2025, p. 794–812.e6, doi:<a href="https://doi.org/10.1016/j.devcel.2024.10.025">10.1016/j.devcel.2024.10.025</a>.
  short: E.C.B. Jaeger, D. Vijatovic, A. Deryckere, N. Zorin, A.L. Nguyen, G. Ivanian,
    J. Woych, R.C. Arnold, A. Ortega Gurrola, A. Shvartsman, F. Barbieri, F.-A. Toma,
    G.J. Gorbsky, M.E. Horb, H.T. Cline, T.F. Shay, D.B. Kelley, A. Yamaguchi, M.
    Shein-Idelson, M.A. Tosches, L.B. Sweeney, Developmental Cell 60 (2025) 794–812.e6.
corr_author: '1'
date_created: 2024-02-20T09:20:32Z
date_published: 2025-03-10T00:00:00Z
date_updated: 2025-09-30T10:00:55Z
day: '10'
ddc:
- '570'
department:
- _id: LoSw
- _id: MaDe
- _id: GaNo
doi: 10.1016/j.devcel.2024.10.025
external_id:
  isi:
  - '001444798600001'
  pmid:
  - '39603234'
file:
- access_level: open_access
  checksum: a83a4cb58f5941096d3ad91ca0172594
  content_type: application/pdf
  creator: dernst
  date_created: 2025-06-04T05:43:27Z
  date_updated: 2025-06-04T05:43:27Z
  file_id: '19790'
  file_name: 2025_DevelopmentalCell_Jaeger.pdf
  file_size: 11936258
  relation: main_file
  success: 1
file_date_updated: 2025-06-04T05:43:27Z
has_accepted_license: '1'
intvolume: '        60'
isi: 1
issue: '5'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 794-812.e6
pmid: 1
project:
- _id: bd73af52-d553-11ed-ba76-912049f0ac7a
  grant_number: FTI21-D-046
  name: Development of V1 interneuron diversity during swim-to-walk transition of
    Xenopus metamorphosis
- _id: ebb66355-77a9-11ec-83b8-b8ac210a4dae
  grant_number: '101041551'
  name: Development and Evolution of Tetrapod Motor Circuits
- _id: 8da85f50-16d5-11f0-9cad-eab8b0ff6c9e
  grant_number: F7814
  name: 'Stem Cell Modulation in Neural Development and Regeneration/ P14-Swim-to-limb
    transition: cell type to connection diversity'
publication: Developmental Cell
publication_identifier:
  eissn:
  - 1878-1551
  issn:
  - 1534-5807
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Adeno-associated viral tools to trace neural development and connectivity across
  amphibians
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 60
year: '2025'
...
---
OA_place: repository
OA_type: green
_id: '19520'
abstract:
- lang: eng
  text: Vertebrates exhibit a wide range of motor behaviors, ranging from swimming
    to complex limb-based movements. Here we take advantage of frog metamorphosis,
    which captures a swim-to-limb-based movement transformation during the development
    of a single organism, to explore changes in the underlying spinal circuits. We
    find that the tadpole spinal cord contains small and largely homogeneous populations
    of motor neurons (MNs) and V1 interneurons (V1s) at early escape swimming stages.
    These neuronal populations only modestly increase in number and subtype heterogeneity
    with the emergence of free swimming. In contrast, during frog metamorphosis and
    the emergence of limb movement, there is a dramatic expansion of MN and V1 interneuron
    number and transcriptional heterogeneity, culminating in cohorts of neurons that
    exhibit striking molecular similarity to mammalian motor circuits. CRISPR/Cas9-mediated
    gene disruption of the limb MN and V1 determinants FoxP1 and Engrailed-1, respectively,
    results in severe but selective deficits in tail and limb function. Our work thus
    demonstrates that neural diversity scales exponentially with increasing behavioral
    complexity and illustrates striking evolutionary conservation in the molecular
    organization and function of motor circuits across species.
acknowledged_ssus:
- _id: Bio
acknowledgement: "We would like to thank the members of the Sweeney Lab (especially
  Stavros Papadopoulos and\r\nSophie Gobeil) for their contributions to this project
  and, in addition to the lab, Graziana Gatto\r\nand Mario de Bono, for discussion,
  and support. We are also grateful to Tom Jessell and Chris\r\nKintner for their
  scientific insight and mentorship during the conception of this project. This\r\nproject
  would also not have been possible with the technical support of the Matthias Nowak,\r\nVerena
  Mayer and the Aquatics as well as the Imaging and Optics Facility support teams\r\n(ISTA).
  In addition, we thank our funding sources for providing the resources to do these\r\nexperiments:
  FTI Strategy Lower Austria Dissertation Grant Number FT121-D-046 (D.V.);\r\nHorizon
  Europe ERC Starting Grant Number 101041551 (L.B.S., F.A.T. and D.V); Special\r\nResearch
  Program (SFB) of the Austrian Science Fund (FWF) Project number F7814-B (L.B.S);\r\nNINDS
  5R35NS116858 (J.S.D); CZI grant DAF2020-225401 (DOI): 10.37921/120055ratwvi\r\n(R.H.);
  NIH grant number R01NS123116 (J.B.B); American Lebanese Syrian Associated\r\nCharities
  (ALSAC) (J.B.B.); German Academic Exchange Service (DAAD) IFI Grant Number\r\n57515251-91853472
  (Z.H.); and Project A.L.S. (S.B-M.). "
article_processing_charge: No
author:
- first_name: David
  full_name: Vijatovic, David
  id: cf391e77-ec3c-11ea-a124-d69323410b58
  last_name: Vijatovic
- first_name: 'Florina Alexandra '
  full_name: 'Toma, Florina Alexandra '
  id: 2f73f876-f128-11eb-9611-b96b5a30cb0e
  last_name: Toma
- first_name: Zoe P
  full_name: Harrington, Zoe P
  id: a8144562-32c9-11ee-b5ce-d9800628bda2
  last_name: Harrington
  orcid: 0009-0008-0158-4032
- first_name: Christoph M
  full_name: Sommer, Christoph M
  id: 4DF26D8C-F248-11E8-B48F-1D18A9856A87
  last_name: Sommer
  orcid: 0000-0003-1216-9105
- first_name: Robert
  full_name: Hauschild, Robert
  id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87
  last_name: Hauschild
  orcid: 0000-0001-9843-3522
- first_name: Alexandra J.
  full_name: Trevisan, Alexandra J.
  last_name: Trevisan
- first_name: Phillip
  full_name: Chapman, Phillip
  last_name: Chapman
- first_name: Mara
  full_name: Julseth, Mara
  id: 1cf464b2-dc7d-11ea-9b2f-f9b1aa9417d1
  last_name: Julseth
- first_name: Susan
  full_name: Brenner-Morton, Susan
  last_name: Brenner-Morton
- first_name: Mariano I.
  full_name: Gabitto, Mariano I.
  last_name: Gabitto
- first_name: Jeremy S.
  full_name: Dasen, Jeremy S.
  last_name: Dasen
- first_name: Jay B.
  full_name: Bikoff, Jay B.
  last_name: Bikoff
- first_name: Lora Beatrice Jaeger
  full_name: Sweeney, Lora Beatrice Jaeger
  id: 56BE8254-C4F0-11E9-8E45-0B23E6697425
  last_name: Sweeney
  orcid: 0000-0001-9242-5601
citation:
  ama: Vijatovic D, Toma FA, Harrington ZP, et al. Spinal neuron diversity scales
    exponentially with swim-to-limb transformation during frog metamorphosis. <i>bioRxiv</i>.
    doi:<a href="https://doi.org/10.1101/2024.09.20.614050">10.1101/2024.09.20.614050</a>
  apa: Vijatovic, D., Toma, F. A., Harrington, Z. P., Sommer, C. M., Hauschild, R.,
    Trevisan, A. J., … Sweeney, L. B. (n.d.). Spinal neuron diversity scales exponentially
    with swim-to-limb transformation during frog metamorphosis. <i>bioRxiv</i>. <a
    href="https://doi.org/10.1101/2024.09.20.614050">https://doi.org/10.1101/2024.09.20.614050</a>
  chicago: Vijatovic, David, Florina Alexandra  Toma, Zoe P Harrington, Christoph
    M Sommer, Robert Hauschild, Alexandra J. Trevisan, Phillip Chapman, et al. “Spinal
    Neuron Diversity Scales Exponentially with Swim-to-Limb Transformation during
    Frog Metamorphosis.” <i>BioRxiv</i>, n.d. <a href="https://doi.org/10.1101/2024.09.20.614050">https://doi.org/10.1101/2024.09.20.614050</a>.
  ieee: D. Vijatovic <i>et al.</i>, “Spinal neuron diversity scales exponentially
    with swim-to-limb transformation during frog metamorphosis,” <i>bioRxiv</i>. .
  ista: Vijatovic D, Toma FA, Harrington ZP, Sommer CM, Hauschild R, Trevisan AJ,
    Chapman P, Julseth M, Brenner-Morton S, Gabitto MI, Dasen JS, Bikoff JB, Sweeney
    LB. Spinal neuron diversity scales exponentially with swim-to-limb transformation
    during frog metamorphosis. bioRxiv, <a href="https://doi.org/10.1101/2024.09.20.614050">10.1101/2024.09.20.614050</a>.
  mla: Vijatovic, David, et al. “Spinal Neuron Diversity Scales Exponentially with
    Swim-to-Limb Transformation during Frog Metamorphosis.” <i>BioRxiv</i>, doi:<a
    href="https://doi.org/10.1101/2024.09.20.614050">10.1101/2024.09.20.614050</a>.
  short: D. Vijatovic, F.A. Toma, Z.P. Harrington, C.M. Sommer, R. Hauschild, A.J.
    Trevisan, P. Chapman, M. Julseth, S. Brenner-Morton, M.I. Gabitto, J.S. Dasen,
    J.B. Bikoff, L.B. Sweeney, BioRxiv (n.d.).
corr_author: '1'
date_created: 2025-04-07T08:48:28Z
date_published: 2024-09-27T00:00:00Z
date_updated: 2025-05-14T11:40:13Z
day: '27'
department:
- _id: LoSw
- _id: TiVo
- _id: Bio
- _id: NiBa
doi: 10.1101/2024.09.20.614050
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1101/2024.09.20.614050
month: '09'
oa: 1
oa_version: Preprint
project:
- _id: bd73af52-d553-11ed-ba76-912049f0ac7a
  grant_number: FTI21-D-046
  name: Development of V1 interneuron diversity during swim-to-walk transition of
    Xenopus metamorphosis
- _id: ebb66355-77a9-11ec-83b8-b8ac210a4dae
  grant_number: '101041551'
  name: Development and Evolution of Tetrapod Motor Circuits
- _id: c08e9ad1-5a5b-11eb-8a69-9d1cf3b07473
  grant_number: CZI01
  name: Tools for automation and feedback microscopy
publication: bioRxiv
publication_status: submitted
status: public
title: Spinal neuron diversity scales exponentially with swim-to-limb transformation
  during frog metamorphosis
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2024'
...