[{"OA_type":"green","publication_status":"submitted","date_published":"2026-05-30T00:00:00Z","author":[{"full_name":"Ge, Zengxiang","orcid":"0000-0001-9381-3577","last_name":"Ge","id":"f43371a3-09ff-11eb-8013-bd0c6a2f6de8","first_name":"Zengxiang"},{"full_name":"Koczka, Lilla","first_name":"Lilla","last_name":"Koczka"},{"last_name":"Mazur","first_name":"Ewa","full_name":"Mazur, Ewa"},{"first_name":"Gergely","id":"34F1AF46-F248-11E8-B48F-1D18A9856A87","last_name":"Molnar","full_name":"Molnar, Gergely"},{"full_name":"Vladimirtsev, Dmitrii","id":"60466724-5355-11ee-ae5a-fa55e8f99c3d","last_name":"Vladimirtsev","first_name":"Dmitrii"},{"full_name":"Kassem, Nada","first_name":"Nada","last_name":"Kassem"},{"full_name":"Ait Ikene, Sara","first_name":"Sara","id":"6a0bb896-6bad-11f1-9bef-906e9eb76034","last_name":"Ait Ikene"},{"full_name":"Fiedler, Lukas","id":"7c417475-8972-11ed-ae7b-8b674ca26986","last_name":"Fiedler","first_name":"Lukas"},{"first_name":"Jiří","last_name":"Friml","orcid":"0000-0002-8302-7596","id":"4159519E-F248-11E8-B48F-1D18A9856A87","full_name":"Friml, Jiří"}],"title":"MAKR6 integrates TMK and CAMEL/CANAR signalling for auxin canalization in Arabidopsis","doi":"10.1101/2025.10.07.680881","oa_version":"Preprint","language":[{"iso":"eng"}],"department":[{"_id":"GradSch"},{"_id":"JiFr"}],"main_file_link":[{"url":"https://doi.org/10.1101/2025.10.07.680881","open_access":"1"}],"citation":{"short":"Z. Ge, L. Koczka, E. Mazur, G. Molnar, D. Vladimirtsev, N. Kassem, S. Ait Ikene, L. Fiedler, J. Friml, BioRxiv (n.d.).","chicago":"Ge, Zengxiang, Lilla Koczka, Ewa Mazur, Gergely Molnar, Dmitrii Vladimirtsev, Nada Kassem, Sara Ait Ikene, Lukas Fiedler, and Jiří Friml. “MAKR6 Integrates TMK and CAMEL/CANAR Signalling for Auxin Canalization in Arabidopsis.” <i>BioRxiv</i>, n.d. <a href=\"https://doi.org/10.1101/2025.10.07.680881\">https://doi.org/10.1101/2025.10.07.680881</a>.","apa":"Ge, Z., Koczka, L., Mazur, E., Molnar, G., Vladimirtsev, D., Kassem, N., … Friml, J. (n.d.). MAKR6 integrates TMK and CAMEL/CANAR signalling for auxin canalization in Arabidopsis. <i>bioRxiv</i>. <a href=\"https://doi.org/10.1101/2025.10.07.680881\">https://doi.org/10.1101/2025.10.07.680881</a>","ieee":"Z. Ge <i>et al.</i>, “MAKR6 integrates TMK and CAMEL/CANAR signalling for auxin canalization in Arabidopsis,” <i>bioRxiv</i>. .","mla":"Ge, Zengxiang, et al. “MAKR6 Integrates TMK and CAMEL/CANAR Signalling for Auxin Canalization in Arabidopsis.” <i>BioRxiv</i>, doi:<a href=\"https://doi.org/10.1101/2025.10.07.680881\">10.1101/2025.10.07.680881</a>.","ama":"Ge Z, Koczka L, Mazur E, et al. MAKR6 integrates TMK and CAMEL/CANAR signalling for auxin canalization in Arabidopsis. <i>bioRxiv</i>. doi:<a href=\"https://doi.org/10.1101/2025.10.07.680881\">10.1101/2025.10.07.680881</a>","ista":"Ge Z, Koczka L, Mazur E, Molnar G, Vladimirtsev D, Kassem N, Ait Ikene S, Fiedler L, Friml J. MAKR6 integrates TMK and CAMEL/CANAR signalling for auxin canalization in Arabidopsis. bioRxiv, <a href=\"https://doi.org/10.1101/2025.10.07.680881\">10.1101/2025.10.07.680881</a>."},"status":"public","date_created":"2026-06-13T16:57:07Z","_id":"21994","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","image":"/images/cc_by_nc_nd.png","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)"},"date_updated":"2026-06-19T07:14:01Z","project":[{"_id":"8f347782-16d5-11f0-9cad-8c19706ee739","name":"Cyclic nucleotides as second messengers in plants","grant_number":"101142681"},{"name":"Peptide receptors for auxin canalization in Arabidopsis","_id":"bd76d395-d553-11ed-ba76-f678c14f9033","grant_number":"I06123"},{"grant_number":"P37051","_id":"7bcece63-9f16-11ee-852c-ae94e099eeb6","name":"Guanylate cyclase activity of TIR1/AFBs auxin receptors"}],"fulldoi":"https://doi.org/10.1101/2025.10.07.680881","year":"2026","license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","type":"preprint","month":"05","oa":1,"article_processing_charge":"No","publication":"bioRxiv","OA_place":"repository","acknowledgement":"We would like to thank Dr. Yvon Jaillais (ENS, Lyon) for sharing MAKR2 materials. This research was supported by the Scientific Service Units (SSU) of ISTA through resources provided by the Imaging & Optics Facility (IOF) and the Lab Support Facility (LSF). The research in the Friml group leading to these results was funded by the European Research Council (ERC): 101142681 CYNIPS; and the Austrian Science Fund (FWF): I 6123-B and P 37051-B. Ewa Mazur was supported by the National Science Centre (NCN), Poland, under the OPUS call in the WEAVE programme: 2021/43/I/NZ1/01835.","has_accepted_license":"1","ddc":["580"],"corr_author":"1","scopus_import":"1","abstract":[{"text":"Adaptive plant development is orchestrated, among others, by directional, intercellular transport of the phytohormone auxin. Self-organizing development, such as flexible vasculature formation, depends on so-called auxin canalization, manifested by the gradual formation of auxin transport channels through feedback between auxin signalling and transport. Herein, we identify MAKR6 as an important, novel component in this feedback. MAKR6 expression accumulates strongly in vascular cells and is tightly regulated by auxin via the Aux/IAA-ARF-WRKY23 transcriptional network. MAKR6 is required for auxin canalization-dependent processes, including leaf venation, vasculature regeneration, and de novo auxin channel formation from local auxin sources. Mechanistically, MAKR6 interacts with the PIN1 auxin transporter, modulating its trafficking and polarization. MAKR6 also associates with and integrates two key receptor-like kinase complexes involved in canalization, TMK1/4 and the CAMEL-CANAR. Together, our study establishes MAKR6 as a multifaceted regulator that couples transcriptional auxin signalling to PIN1 repolarization and coordinates multiple RLK-mediated signalling pathways during canalization. This provides mechanistic insights into auxin canalization and exemplifies a framework for exploring similar regulatory nodes in other developmental contexts.","lang":"eng"}],"day":"30"},{"abstract":[{"lang":"eng","text":"In order to cope with arid terrestrial environments, angiosperms have evolved a unique fertilization way—siphonogamy. The success of siphonogamy requires several prerequisites, including the normal development of the female gametophyte and male gametophyte (pollen). Appropriate pollination methods ensure the successful encounter between pollen and the stigma. After pollen lands on the stigma, pollen/pollen tube interacts with different tissues and cells of the pistil, completing a series of male-female communications. The smooth progress of these interactions ensures that the pollen tube can enter the female gametophyte, burst, and release sperm cells to complete the double fertilization. In this chapter, we provide an overview of pollination and the interactions between male and female, comprehensively summarizing the factors involved in these processes."}],"scopus_import":"1","publication_identifier":{"isbn":["9789819570324"],"eisbn":["9789819570331"]},"day":"24","publisher":"Springer Nature","article_processing_charge":"No","publication":"Regulation of Plant Development","month":"04","type":"book_chapter","place":"Singapore","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","year":"2026","fulldoi":"https://doi.org/10.1007/978-981-95-7033-1_14","date_created":"2026-07-13T09:46:18Z","date_updated":"2026-07-13T12:25:19Z","_id":"22293","quality_controlled":"1","citation":{"ieee":"S. Zhong, Z. Lan, Z. Ge, and L.-J. Qu, “Pollination and Fertilization,” in <i>Regulation of Plant Development</i>, F. Chang, Y. Wang, and H. Ma, Eds. Singapore: Springer Nature, 2026, pp. 537–615.","ista":"Zhong S, Lan Z, Ge Z, Qu L-J. 2026.Pollination and Fertilization. In: Regulation of Plant Development. , 537–615.","ama":"Zhong S, Lan Z, Ge Z, Qu L-J. Pollination and Fertilization. In: Chang F, Wang Y, Ma H, eds. <i>Regulation of Plant Development</i>. Singapore: Springer Nature; 2026:537-615. doi:<a href=\"https://doi.org/10.1007/978-981-95-7033-1_14\">10.1007/978-981-95-7033-1_14</a>","mla":"Zhong, Sheng, et al. “Pollination and Fertilization.” <i>Regulation of Plant Development</i>, edited by Fang  Chang et al., Springer Nature, 2026, pp. 537–615, doi:<a href=\"https://doi.org/10.1007/978-981-95-7033-1_14\">10.1007/978-981-95-7033-1_14</a>.","short":"S. Zhong, Z. Lan, Z. Ge, L.-J. Qu, in:, F. Chang, Y. Wang, H. Ma (Eds.), Regulation of Plant Development, Springer Nature, Singapore, 2026, pp. 537–615.","chicago":"Zhong, Sheng, Zijun Lan, Zengxiang Ge, and Li-Jia Qu. “Pollination and Fertilization.” In <i>Regulation of Plant Development</i>, edited by Fang  Chang, Yingxiang Wang, and Hong Ma, 537–615. Singapore: Springer Nature, 2026. <a href=\"https://doi.org/10.1007/978-981-95-7033-1_14\">https://doi.org/10.1007/978-981-95-7033-1_14</a>.","apa":"Zhong, S., Lan, Z., Ge, Z., &#38; Qu, L.-J. (2026). Pollination and Fertilization. In F. Chang, Y. Wang, &#38; H. Ma (Eds.), <i>Regulation of Plant Development</i> (pp. 537–615). Singapore: Springer Nature. <a href=\"https://doi.org/10.1007/978-981-95-7033-1_14\">https://doi.org/10.1007/978-981-95-7033-1_14</a>"},"department":[{"_id":"JiFr"}],"status":"public","oa_version":"None","language":[{"iso":"eng"}],"editor":[{"last_name":"Chang","first_name":"Fang ","full_name":"Chang, Fang "},{"last_name":"Wang","first_name":"Yingxiang","full_name":"Wang, Yingxiang"},{"full_name":"Ma, Hong","last_name":"Ma","first_name":"Hong"}],"doi":"10.1007/978-981-95-7033-1_14","title":"Pollination and Fertilization","das_tickbox":"1","page":"537-615","author":[{"first_name":"Sheng","last_name":"Zhong","full_name":"Zhong, Sheng"},{"last_name":"Lan","first_name":"Zijun","full_name":"Lan, Zijun"},{"first_name":"Zengxiang","orcid":"0000-0001-9381-3577","last_name":"Ge","id":"f43371a3-09ff-11eb-8013-bd0c6a2f6de8","full_name":"Ge, Zengxiang"},{"first_name":"Li-Jia","last_name":"Qu","full_name":"Qu, Li-Jia"}],"date_published":"2026-04-24T00:00:00Z","publication_status":"published","OA_type":"closed access"},{"month":"05","oa":1,"article_processing_charge":"No","external_id":{"pmid":["38142229"]},"publication":"The Plant Cell","has_accepted_license":"1","ddc":["580"],"publisher":"Oxford University Press","publication_identifier":{"issn":["1040-4651"],"eissn":["1532-298X"]},"abstract":[{"text":"Autocrine signaling pathways regulated by RAPID ALKALINIZATION FACTORs (RALFs) control cell wall integrity during pollen tube germination and growth in Arabidopsis (Arabidopsis thaliana). To investigate the role of pollen-specific RALFs in another plant species, we combined gene expression data with phylogenetic and biochemical studies to identify candidate orthologs in maize (Zea mays). We show that Clade IB ZmRALF2/3 mutations, but not Clade III ZmRALF1/5 mutations, cause cell wall instability in the sub-apical region of the growing pollen tube. ZmRALF2/3 are mainly located in the cell wall and are partially able to complement the pollen germination defect of their Arabidopsis orthologs AtRALF4/19. Mutations in ZmRALF2/3 compromise pectin distribution patterns leading to altered cell wall organization and thickness culminating in pollen tube burst. Clade IB, but not Clade III ZmRALFs, strongly interact as ligands with the pollen-specific Catharanthus roseus RLK1-like (CrRLK1L) receptor kinases Zea mays FERONIA-like (ZmFERL) 4/7/9, LORELEI-like glycosylphosphatidylinositol-anchor (LLG) proteins Zea mays LLG 1 and 2 (ZmLLG1/2) and Zea mays pollen extension-like (PEX) cell wall proteins ZmPEX2/4. Notably, ZmFERL4 outcompetes ZmLLG2 and ZmPEX2 outcompetes ZmFERL4 for ZmRALF2 binding. Based on these data, we suggest that Clade IB RALFs act in a dual role as cell wall components and extracellular sensors to regulate cell wall integrity and thickness during pollen tube growth in maize and probably other plants.","lang":"eng"}],"scopus_import":"1","day":"01","volume":36,"fulldoi":"https://doi.org/10.1093/plcell/koad324","year":"2024","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","issue":"5","article_type":"original","type":"journal_article","oa_version":"Published Version","extern":"1","language":[{"iso":"eng"}],"main_file_link":[{"url":"https://doi.org/10.1093/plcell/koad324","open_access":"1"}],"citation":{"ieee":"L.-Z. Zhou <i>et al.</i>, “The RALF signaling pathway regulates cell wall integrity during pollen tube growth in maize,” <i>The Plant Cell</i>, vol. 36, no. 5. Oxford University Press, 2024.","mla":"Zhou, Liang-Zi, et al. “The RALF Signaling Pathway Regulates Cell Wall Integrity during Pollen Tube Growth in Maize.” <i>The Plant Cell</i>, vol. 36, no. 5, koad324, Oxford University Press, 2024, doi:<a href=\"https://doi.org/10.1093/plcell/koad324\">10.1093/plcell/koad324</a>.","ama":"Zhou L-Z, Wang L, Chen X, et al. The RALF signaling pathway regulates cell wall integrity during pollen tube growth in maize. <i>The Plant Cell</i>. 2024;36(5). doi:<a href=\"https://doi.org/10.1093/plcell/koad324\">10.1093/plcell/koad324</a>","ista":"Zhou L-Z, Wang L, Chen X, Ge Z, Mergner J, Li X, Küster B, Längst G, Qu L-J, Dresselhaus T. 2024. The RALF signaling pathway regulates cell wall integrity during pollen tube growth in maize. The Plant Cell. 36(5), koad324.","short":"L.-Z. Zhou, L. Wang, X. Chen, Z. Ge, J. Mergner, X. Li, B. Küster, G. Längst, L.-J. Qu, T. Dresselhaus, The Plant Cell 36 (2024).","chicago":"Zhou, Liang-Zi, Lele Wang, Xia Chen, Zengxiang Ge, Julia Mergner, Xingli Li, Bernhard Küster, Gernot Längst, Li-Jia Qu, and Thomas Dresselhaus. “The RALF Signaling Pathway Regulates Cell Wall Integrity during Pollen Tube Growth in Maize.” <i>The Plant Cell</i>. Oxford University Press, 2024. <a href=\"https://doi.org/10.1093/plcell/koad324\">https://doi.org/10.1093/plcell/koad324</a>.","apa":"Zhou, L.-Z., Wang, L., Chen, X., Ge, Z., Mergner, J., Li, X., … Dresselhaus, T. (2024). The RALF signaling pathway regulates cell wall integrity during pollen tube growth in maize. <i>The Plant Cell</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/plcell/koad324\">https://doi.org/10.1093/plcell/koad324</a>"},"status":"public","intvolume":"        36","date_created":"2024-01-02T11:19:37Z","quality_controlled":"1","article_number":"koad324","date_updated":"2024-07-16T11:18:46Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","image":"/images/cc_by_nc_nd.png","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)"},"_id":"14726","date_published":"2024-05-01T00:00:00Z","author":[{"last_name":"Zhou","first_name":"Liang-Zi","full_name":"Zhou, Liang-Zi"},{"first_name":"Lele","last_name":"Wang","full_name":"Wang, Lele"},{"full_name":"Chen, Xia","first_name":"Xia","last_name":"Chen"},{"first_name":"Zengxiang","orcid":"0000-0001-9381-3577","last_name":"Ge","id":"f43371a3-09ff-11eb-8013-bd0c6a2f6de8","full_name":"Ge, Zengxiang"},{"full_name":"Mergner, Julia","last_name":"Mergner","first_name":"Julia"},{"first_name":"Xingli","last_name":"Li","full_name":"Li, Xingli"},{"first_name":"Bernhard","last_name":"Küster","full_name":"Küster, Bernhard"},{"last_name":"Längst","first_name":"Gernot","full_name":"Längst, Gernot"},{"first_name":"Li-Jia","last_name":"Qu","full_name":"Qu, Li-Jia"},{"last_name":"Dresselhaus","first_name":"Thomas","full_name":"Dresselhaus, Thomas"}],"pmid":1,"publication_status":"published","keyword":["Cell Biology","Plant Science"],"title":"The RALF signaling pathway regulates cell wall integrity during pollen tube growth in maize","doi":"10.1093/plcell/koad324"},{"month":"12","external_id":{"pmid":["39501563"],"isi":["001373778300001"]},"publication":"Molecular Plant","OA_place":"publisher","oa":1,"article_processing_charge":"Yes (in subscription journal)","publisher":"Elsevier","acknowledgement":"We dedicate this paper to the deceased Petr Galuszka for his inspiration and support of our project. We thank Prof. Peter Hedden for constructive criticism of the manuscript and English editing. No conflict of interest is declared.","ddc":["580"],"has_accepted_license":"1","day":"02","volume":17,"publication_identifier":{"issn":["1674-2052"]},"abstract":[{"text":"Hormone perception and signaling pathways have a fundamental regulatory function in the physiological processes of plants. Cytokinins, a class of plant hormones, regulate cell division and meristem maintenance. The cytokinin signaling pathway is well established in the model plant Arabidopsis thaliana. Several negative feedback mechanisms, tightly controlling cytokinin signaling output, have been described previously. In this study, we identified a new feedback mechanism executed through alternative splicing of the cytokinin receptor AHK4/CRE1. A novel splicing variant named CRE1int7 results from seventh intron retention, introducing a premature termination codon in the transcript. We showed that CRE1int7 is translated in planta into a truncated receptor lacking the C-terminal receiver domain essential for signal transduction. CRE1int7 can bind cytokinin but cannot activate the downstream cascade. We present a novel negative feedback mechanism of the cytokinin signaling pathway, facilitated by a decoy receptor that can inactivate canonical cytokinin receptors via dimerization and compete with them for ligand binding. Ensuring proper plant growth and development requires precise control of the cytokinin signaling pathway at several levels. CRE1int7 represents a so-far unknown mechanism for fine-tuning the cytokinin signaling pathway in Arabidopsis.","lang":"eng"}],"scopus_import":"1","fulldoi":"https://doi.org/10.1016/j.molp.2024.11.001","year":"2024","supplementarymaterial":"yes","issue":"12","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","article_type":"original","acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"}],"type":"journal_article","language":[{"iso":"eng"}],"oa_version":"Published Version","status":"public","department":[{"_id":"JiFr"},{"_id":"EvBe"}],"citation":{"mla":"Králová, Michaela, et al. “A Decoy Receptor Derived from Alternative Splicing Fine-Tunes Cytokinin Signaling in Arabidopsis.” <i>Molecular Plant</i>, vol. 17, no. 12, Elsevier, 2024, pp. 1850–65, doi:<a href=\"https://doi.org/10.1016/j.molp.2024.11.001\">10.1016/j.molp.2024.11.001</a>.","ama":"Králová M, Kubalová I, Hajný J, et al. A decoy receptor derived from alternative splicing fine-tunes cytokinin signaling in Arabidopsis. <i>Molecular Plant</i>. 2024;17(12):1850-1865. doi:<a href=\"https://doi.org/10.1016/j.molp.2024.11.001\">10.1016/j.molp.2024.11.001</a>","ista":"Králová M, Kubalová I, Hajný J, Kubiasova K, Vagaská K, Ge Z, Gallei MC, Semerádová H, Kuchařová A, Hönig M, Monzer A, Kovačik M, Friml J, Novák O, Benková E, Ikeda Y, Zalabák D. 2024. A decoy receptor derived from alternative splicing fine-tunes cytokinin signaling in Arabidopsis. Molecular Plant. 17(12), 1850–1865.","ieee":"M. Králová <i>et al.</i>, “A decoy receptor derived from alternative splicing fine-tunes cytokinin signaling in Arabidopsis,” <i>Molecular Plant</i>, vol. 17, no. 12. Elsevier, pp. 1850–1865, 2024.","apa":"Králová, M., Kubalová, I., Hajný, J., Kubiasova, K., Vagaská, K., Ge, Z., … Zalabák, D. (2024). A decoy receptor derived from alternative splicing fine-tunes cytokinin signaling in Arabidopsis. <i>Molecular Plant</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.molp.2024.11.001\">https://doi.org/10.1016/j.molp.2024.11.001</a>","chicago":"Králová, Michaela, Ivona Kubalová, Jakub Hajný, Karolina Kubiasova, Karolína Vagaská, Zengxiang Ge, Michelle C Gallei, et al. “A Decoy Receptor Derived from Alternative Splicing Fine-Tunes Cytokinin Signaling in Arabidopsis.” <i>Molecular Plant</i>. Elsevier, 2024. <a href=\"https://doi.org/10.1016/j.molp.2024.11.001\">https://doi.org/10.1016/j.molp.2024.11.001</a>.","short":"M. Králová, I. Kubalová, J. Hajný, K. Kubiasova, K. Vagaská, Z. Ge, M.C. Gallei, H. Semerádová, A. Kuchařová, M. Hönig, A. Monzer, M. Kovačik, J. Friml, O. Novák, E. Benková, Y. Ikeda, D. Zalabák, Molecular Plant 17 (2024) 1850–1865."},"quality_controlled":"1","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","image":"/images/cc_by_nc_nd.png","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)"},"date_updated":"2026-10-15T08:30:20Z","_id":"18596","intvolume":"        17","researchdata_availability":"no","date_created":"2024-11-28T11:13:35Z","OA_type":"hybrid","file":[{"access_level":"open_access","file_id":"18612","file_name":"2024_MolecularPlant_Kralova.pdf","date_updated":"2024-12-03T11:08:09Z","checksum":"a11feea4b1677df76b632eca04bfc1dd","relation":"main_file","success":1,"date_created":"2024-12-03T11:08:09Z","creator":"dernst","content_type":"application/pdf","file_size":3308945}],"publication_status":"published","pmid":1,"date_published":"2024-12-02T00:00:00Z","author":[{"full_name":"Králová, 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Anna","last_name":"Kuchařová","first_name":"Anna"},{"last_name":"Hönig","first_name":"Martin","full_name":"Hönig, Martin"},{"full_name":"Monzer, Aline","first_name":"Aline","id":"2DB5D88C-D7B3-11E9-B8FD-7907E6697425","last_name":"Monzer"},{"full_name":"Kovačik, Martin","first_name":"Martin","last_name":"Kovačik"},{"full_name":"Friml, Jiří","first_name":"Jiří","last_name":"Friml","orcid":"0000-0002-8302-7596","id":"4159519E-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Novák","first_name":"Ondřej","full_name":"Novák, Ondřej"},{"id":"38F4F166-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8510-9739","last_name":"Benková","first_name":"Eva","full_name":"Benková, Eva"},{"first_name":"Yoshihisa","last_name":"Ikeda","full_name":"Ikeda, Yoshihisa"},{"last_name":"Zalabák","first_name":"David","full_name":"Zalabák, David"}],"page":"1850-1865","isi":1,"das_tickbox":"0","file_date_updated":"2024-12-03T11:08:09Z","title":"A decoy receptor derived from alternative splicing fine-tunes cytokinin signaling in Arabidopsis","doi":"10.1016/j.molp.2024.11.001"},{"date_published":"2022-01-20T00:00:00Z","author":[{"full_name":"Zhong, Sheng","last_name":"Zhong","first_name":"Sheng"},{"full_name":"Li, Ling","first_name":"Ling","last_name":"Li"},{"last_name":"Wang","first_name":"Zhijuan","full_name":"Wang, Zhijuan"},{"full_name":"Ge, Zengxiang","first_name":"Zengxiang","id":"f43371a3-09ff-11eb-8013-bd0c6a2f6de8","orcid":"0000-0001-9381-3577","last_name":"Ge"},{"full_name":"Li, Qiyun","first_name":"Qiyun","last_name":"Li"},{"full_name":"Bleckmann, Andrea","last_name":"Bleckmann","first_name":"Andrea"},{"full_name":"Wang, Jizong","first_name":"Jizong","last_name":"Wang"},{"full_name":"Song, Zihan","first_name":"Zihan","last_name":"Song"},{"full_name":"Shi, Yihao","last_name":"Shi","first_name":"Yihao"},{"full_name":"Liu, Tianxu","first_name":"Tianxu","last_name":"Liu"},{"full_name":"Li, Luhan","last_name":"Li","first_name":"Luhan"},{"last_name":"Zhou","first_name":"Huabin","full_name":"Zhou, Huabin"},{"full_name":"Wang, Yanyan","last_name":"Wang","first_name":"Yanyan"},{"first_name":"Li","last_name":"Zhang","full_name":"Zhang, Li"},{"full_name":"Wu, Hen-Ming","last_name":"Wu","first_name":"Hen-Ming"},{"full_name":"Lai, Luhua","last_name":"Lai","first_name":"Luhua"},{"full_name":"Gu, Hongya","last_name":"Gu","first_name":"Hongya"},{"last_name":"Dong","first_name":"Juan","full_name":"Dong, Juan"},{"full_name":"Cheung, Alice Y.","last_name":"Cheung","first_name":"Alice Y."},{"last_name":"Dresselhaus","first_name":"Thomas","full_name":"Dresselhaus, Thomas"},{"last_name":"Qu","first_name":"Li-Jia","full_name":"Qu, Li-Jia"}],"publication_status":"published","pmid":1,"page":"290-296","title":"RALF peptide signaling controls the polytubey block in Arabidopsis","doi":"10.1126/science.abl4683","OA_type":"green","intvolume":"       375","date_created":"2024-05-29T06:11:10Z","quality_controlled":"1","date_updated":"2025-04-24T11:39:46Z","_id":"17069","oa_version":"Submitted Version","language":[{"iso":"eng"}],"department":[{"_id":"JiFr"}],"main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9040003","open_access":"1"}],"citation":{"apa":"Zhong, S., Li, L., Wang, Z., Ge, Z., Li, Q., Bleckmann, A., … Qu, L.-J. (2022). RALF peptide signaling controls the polytubey block in Arabidopsis. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.abl4683\">https://doi.org/10.1126/science.abl4683</a>","chicago":"Zhong, Sheng, Ling Li, Zhijuan Wang, Zengxiang Ge, Qiyun Li, Andrea Bleckmann, Jizong Wang, et al. “RALF Peptide Signaling Controls the Polytubey Block in Arabidopsis.” <i>Science</i>. American Association for the Advancement of Science, 2022. <a href=\"https://doi.org/10.1126/science.abl4683\">https://doi.org/10.1126/science.abl4683</a>.","short":"S. Zhong, L. Li, Z. Wang, Z. Ge, Q. Li, A. Bleckmann, J. Wang, Z. Song, Y. Shi, T. Liu, L. Li, H. Zhou, Y. Wang, L. Zhang, H.-M. Wu, L. Lai, H. Gu, J. Dong, A.Y. Cheung, T. Dresselhaus, L.-J. Qu, Science 375 (2022) 290–296.","mla":"Zhong, Sheng, et al. “RALF Peptide Signaling Controls the Polytubey Block in Arabidopsis.” <i>Science</i>, vol. 375, no. 6578, American Association for the Advancement of Science, 2022, pp. 290–96, doi:<a href=\"https://doi.org/10.1126/science.abl4683\">10.1126/science.abl4683</a>.","ama":"Zhong S, Li L, Wang Z, et al. RALF peptide signaling controls the polytubey block in Arabidopsis. <i>Science</i>. 2022;375(6578):290-296. doi:<a href=\"https://doi.org/10.1126/science.abl4683\">10.1126/science.abl4683</a>","ista":"Zhong S, Li L, Wang Z, Ge Z, Li Q, Bleckmann A, Wang J, Song Z, Shi Y, Liu T, Li L, Zhou H, Wang Y, Zhang L, Wu H-M, Lai L, Gu H, Dong J, Cheung AY, Dresselhaus T, Qu L-J. 2022. RALF peptide signaling controls the polytubey block in Arabidopsis. Science. 375(6578), 290–296.","ieee":"S. Zhong <i>et al.</i>, “RALF peptide signaling controls the polytubey block in Arabidopsis,” <i>Science</i>, vol. 375, no. 6578. American Association for the Advancement of Science, pp. 290–296, 2022."},"status":"public","article_type":"original","type":"journal_article","fulldoi":"https://doi.org/10.1126/science.abl4683","year":"2022","issue":"6578","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","acknowledgement":"We thank D. Ye for providing fer-4 and myb97 myb101 myb120 mutant seeds; L. Smith for sharing anj, herk1, anj herk1, and fer anj herk1 mutant seeds; J. F. Harper for providing aca9 mutant seeds; and C. Li and Q. Duan for sharing fer+/− mutant seeds.\r\nL.-J.Q. was funded by the National Natural Science Foundation of China (grant nos. 31991202, 31830004, 31620103903, and 31621001), S.Z. was supported by the Young Elite Scientists Sponsorship Program by the China Association of Science and Technology (2019QNRC001), Z.G. was supported by a NSFC Young Scientists Fund (31900161), A.Y.C. was funded by the US Natural Science Foundation (IOS-1645854, MCB-1715764, and MCB-0955910), J.D. was funded by the National Institute of Health (R01GM109080), and T.D. was supported by the German Research Foundation DFG (SFB924).","publisher":"American Association for the Advancement of Science","publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"scopus_import":"1","abstract":[{"text":"Fertilization of an egg by multiple sperm (polyspermy) leads to lethal genome imbalance and chromosome segregation defects. In Arabidopsis thaliana, the block to polyspermy is facilitated by a mechanism that prevents polytubey (the arrival of multiple pollen tubes to one ovule). We show here that FERONIA, ANJEA, and HERCULES RECEPTOR KINASE 1 receptor-like kinases located at the septum interact with pollen tube–specific RALF6, 7, 16, 36, and 37 peptide ligands to establish this polytubey block. The same combination of RALF (rapid alkalinization factor) peptides and receptor complexes controls pollen tube reception and rupture inside the targeted ovule. Pollen tube rupture releases the polytubey block at the septum, which allows the emergence of secondary pollen tubes upon fertilization failure. Thus, orchestrated steps in the fertilization process in Arabidopsis are coordinated by the same signaling components to guarantee and optimize reproductive success.","lang":"eng"}],"day":"20","volume":375,"month":"01","oa":1,"article_processing_charge":"No","external_id":{"pmid":["35050671"]},"publication":"Science","OA_place":"repository"}]