---
OA_place: publisher
_id: '22735'
acknowledged_ssus:
- _id: M-Shop
- _id: PreCl
- _id: Bio
acknowledgement: "This project was supported by the following funding agencies: ERC
  under the European\r\nUnion's Horizon 2020 research and innovation program (ERC
  Advanced Grants No 692692\r\n“GIANTSYN” and 101199096 “CA3-SYNGRAM” to P.J.), the
  Fonds zur Förderung der\r\nwissenschaftlichen Forschung (P 36232-B, stand-alone
  grant, PAT 4178023, principal\r\ninvestigator project, and 10.55776/CoE 16 “GABA
  neurons” to P.J.), and the European Union’s\r\nHorizon 2020 research and innovation
  programme under the Marie Skłodowska-Curie grant\r\nagreement (No 101034413, to
  K.L.)."
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Peipeng
  full_name: Lin, Peipeng
  id: 7E3060D0-A92C-11E9-A326-26C8E5697425
  last_name: Lin
citation:
  ama: 'Lin P. Calibrating the teacher synapse: Mechanisms and functional significance
    of presynaptic inhibition at hippocampal mossy fiber synapses. 2026. doi:<a href="https://doi.org/10.15479/AT-ISTA-22735">10.15479/AT-ISTA-22735</a>'
  apa: 'Lin, P. (2026). <i>Calibrating the teacher synapse: Mechanisms and functional
    significance of presynaptic inhibition at hippocampal mossy fiber synapses</i>.
    Institute of Science and Technology Austria. <a href="https://doi.org/10.15479/AT-ISTA-22735">https://doi.org/10.15479/AT-ISTA-22735</a>'
  chicago: 'Lin, Peipeng. “Calibrating the Teacher Synapse: Mechanisms and Functional
    Significance of Presynaptic Inhibition at Hippocampal Mossy Fiber Synapses.” Institute
    of Science and Technology Austria, 2026. <a href="https://doi.org/10.15479/AT-ISTA-22735">https://doi.org/10.15479/AT-ISTA-22735</a>.'
  ieee: 'P. Lin, “Calibrating the teacher synapse: Mechanisms and functional significance
    of presynaptic inhibition at hippocampal mossy fiber synapses,” Institute of Science
    and Technology Austria, 2026.'
  ista: 'Lin P. 2026. Calibrating the teacher synapse: Mechanisms and functional significance
    of presynaptic inhibition at hippocampal mossy fiber synapses. Institute of Science
    and Technology Austria.'
  mla: 'Lin, Peipeng. <i>Calibrating the Teacher Synapse: Mechanisms and Functional
    Significance of Presynaptic Inhibition at Hippocampal Mossy Fiber Synapses</i>.
    Institute of Science and Technology Austria, 2026, doi:<a href="https://doi.org/10.15479/AT-ISTA-22735">10.15479/AT-ISTA-22735</a>.'
  short: 'P. Lin, Calibrating the Teacher Synapse: Mechanisms and Functional Significance
    of Presynaptic Inhibition at Hippocampal Mossy Fiber Synapses, Institute of Science
    and Technology Austria, 2026.'
corr_author: '1'
das_tickbox: '0'
date_created: 2026-08-18T15:23:41Z
date_published: 2026-08-25T00:00:00Z
date_updated: 2026-09-16T07:39:42Z
day: '25'
ddc:
- '571'
- '573'
degree_awarded: PhD
department:
- _id: GradSch
- _id: PeJo
doi: 10.15479/AT-ISTA-22735
doi_confirm: '1'
ec_funded: 1
file:
- access_level: closed
  checksum: 13cc7ead72aad90a134f310b531c73cd
  content_type: application/pdf
  creator: plin
  date_created: 2026-08-26T10:09:48Z
  date_updated: 2026-08-26T10:09:48Z
  embargo: 2027-09-01
  embargo_to: open_access
  file_id: '22765'
  file_name: 2026_Lin_Peipeng_Thesis.pdf
  file_size: 6376229
  relation: main_file
- access_level: closed
  checksum: 8c9c1445a7df284377be1a8c9dadd7c5
  content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
  creator: plin
  date_created: 2026-08-26T10:09:53Z
  date_updated: 2026-08-26T10:09:53Z
  file_id: '22766'
  file_name: 2026_Lin_Peipeng_Thesis.docx
  file_size: 17681883
  relation: source_file
file_date_updated: 2026-08-26T10:09:53Z
fulldoi: https://doi.org/10.15479/AT-ISTA-22735
has_accepted_license: '1'
language:
- iso: eng
month: '08'
oa_version: Published Version
page: '88'
project:
- _id: 25B7EB9E-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '692692'
  name: Biophysics and circuit function of a giant cortical glutamatergic synapse
- _id: e62b56fe-ab3c-11f0-94c7-d181dd352b3b
  grant_number: '101199096'
  name: Synaptic mechanisms of engram storage and retrieval in CA3 hippocampal microcircuits
- _id: bd88be38-d553-11ed-ba76-81d5a70a6ef5
  grant_number: P36232
  name: Mechanisms of GABA release in hippocampal circuits
- _id: 8d9195e9-16d5-11f0-9cad-d075be887a1e
  grant_number: PAT 4178023
  name: Synaptic networks of human brain
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
  call_identifier: H2020
  grant_number: '101034413'
  name: 'IST-BRIDGE: International postdoctoral program'
- _id: 0a6c8641-b036-11f1-bacf-e4eec62b5bb4
  grant_number: COE16
  name: Neuronal circuits in health and disease (Jonas)
publication_identifier:
  isbn:
  - 978-3-99078-088-6
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
researchdata_availability: upon request
status: public
supervisor:
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
supplementarymaterial: yes
title: 'Calibrating the teacher synapse: Mechanisms and functional significance of
  presynaptic inhibition at hippocampal mossy fiber synapses'
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: dissertation
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
OA_embargo: '18'
OA_place: publisher
_id: '22775'
acknowledged_ssus:
- _id: Bio
- _id: PreCl
- _id: M-Shop
- _id: LifeSc
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Silvia
  full_name: Jamrichova, Silvia
  id: F0EA6804-AA27-11E9-8613-C0F7E5697425
  last_name: Jamrichova
  orcid: 0009-0003-9929-8221
citation:
  ama: Jamrichova S. Timing and strength of synaptic transmission at hippocampal mossy
    fiber synapses in mice and humans. 2026. doi:<a href="https://doi.org/10.15479/AT-ISTA-22775">10.15479/AT-ISTA-22775</a>
  apa: Jamrichova, S. (2026). <i>Timing and strength of synaptic transmission at hippocampal
    mossy fiber synapses in mice and humans</i>. Institute of Science and Technology
    Austria. <a href="https://doi.org/10.15479/AT-ISTA-22775">https://doi.org/10.15479/AT-ISTA-22775</a>
  chicago: Jamrichova, Silvia. “Timing and Strength of Synaptic Transmission at Hippocampal
    Mossy Fiber Synapses in Mice and Humans.” Institute of Science and Technology
    Austria, 2026. <a href="https://doi.org/10.15479/AT-ISTA-22775">https://doi.org/10.15479/AT-ISTA-22775</a>.
  ieee: S. Jamrichova, “Timing and strength of synaptic transmission at hippocampal
    mossy fiber synapses in mice and humans,” Institute of Science and Technology
    Austria, 2026.
  ista: Jamrichova S. 2026. Timing and strength of synaptic transmission at hippocampal
    mossy fiber synapses in mice and humans. Institute of Science and Technology Austria.
  mla: Jamrichova, Silvia. <i>Timing and Strength of Synaptic Transmission at Hippocampal
    Mossy Fiber Synapses in Mice and Humans</i>. Institute of Science and Technology
    Austria, 2026, doi:<a href="https://doi.org/10.15479/AT-ISTA-22775">10.15479/AT-ISTA-22775</a>.
  short: S. Jamrichova, Timing and Strength of Synaptic Transmission at Hippocampal
    Mossy Fiber Synapses in Mice and Humans, Institute of Science and Technology Austria,
    2026.
corr_author: '1'
date_created: 2026-09-03T08:06:58Z
date_published: 2026-09-03T00:00:00Z
date_updated: 2026-09-16T08:13:41Z
day: '03'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: GradSch
- _id: PeJo
doi: 10.15479/AT-ISTA-22775
doi_confirm: '1'
ec_funded: 1
file:
- access_level: closed
  checksum: d9a6fd39a0b6343c4473901f9323f127
  content_type: application/pdf
  creator: cchlebak
  date_created: 2026-09-08T09:01:22Z
  date_updated: 2026-09-08T09:01:22Z
  embargo: 2028-03-08
  embargo_to: open_access
  file_id: '22850'
  file_name: 2026_Jamrichova_Silvia_Thesis.pdf
  file_size: 8968078
  relation: main_file
- access_level: closed
  checksum: 02b728c9157f88e392b69e94877889f0
  content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
  creator: cchlebak
  date_created: 2026-09-08T09:02:52Z
  date_updated: 2026-09-08T09:02:52Z
  file_id: '22851'
  file_name: 2026_Jamrichova_Silvia_Thesis.docx
  file_size: 17338630
  relation: source_file
file_date_updated: 2026-09-08T09:02:52Z
fulldoi: https://doi.org/10.15479/AT-ISTA-22775
has_accepted_license: '1'
language:
- iso: eng
month: '09'
oa_version: Published Version
page: '153'
project:
- _id: 25B7EB9E-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '692692'
  name: Biophysics and circuit function of a giant cortical glutamatergic synapse
- _id: e62b56fe-ab3c-11f0-94c7-d181dd352b3b
  grant_number: '101199096'
  name: Synaptic mechanisms of engram storage and retrieval in CA3 hippocampal microcircuits
- _id: bd88be38-d553-11ed-ba76-81d5a70a6ef5
  grant_number: P36232
  name: Mechanisms of GABA release in hippocampal circuits
- _id: 8d9195e9-16d5-11f0-9cad-d075be887a1e
  grant_number: PAT 4178023
  name: Synaptic networks of human brain
- _id: 25C5A090-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: Z00312
  name: Synaptic communication in neuronal microcircuits
- _id: 0a6c8641-b036-11f1-bacf-e4eec62b5bb4
  grant_number: COE16
  name: Neuronal circuits in health and disease (Jonas)
publication_identifier:
  isbn:
  - 978-3-99078-085-5
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
researchdata_availability: upon request
status: public
supervisor:
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
supplementarymaterial: no
title: Timing and strength of synaptic transmission at hippocampal mossy fiber synapses
  in mice and humans
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '20099'
abstract:
- lang: eng
  text: The hippocampus, critical for learning and memory, is dogmatically described
    as a trisynaptic circuit where dentate gyrus granule cells (GCs), CA3 pyramidal
    neurons (PNs), and CA1 PNs are serially connected. However, CA3 also forms an
    autoassociative network, and its PNs have diverse morphologies, intrinsic properties,
    and GC input levels. How PN subtypes compose this recurrent network is unknown.
    To determine the synaptic arrangement of identified CA3 PNs, we combine multicellular
    patch-clamp recording and post hoc morphological analysis in mouse hippocampal
    slices. PNs can be divided into distinct “superficial” and “deep” subclasses,
    the latter including previously reported “athorny” cells. Subclasses have distinct
    input-output transformations and asymmetric connectivity, which is more abundant
    from superficial to deep PNs, splitting CA3 locally into two parallel recurrent
    networks. Coincident spontaneous inhibition occurs frequently within but not between
    subclasses, implying subclass-specific inhibitory innervation. Our results suggest
    two separately controlled sublayers for parallel information processing in hippocampal
    CA3.
acknowledged_ssus:
- _id: Bio
- _id: PreCl
- _id: LifeSc
- _id: M-Shop
acknowledgement: We thank Andrea Navas-Olive and Rebecca J. Morse-Mora for critically
  reading an earlier version of the manuscript. We also thank Florian Marr and Christina
  Altmutter for excellent technical assistance, Alois Schlögl for programming and
  data-handling assistance, Todor Asenov for technical support, and Eleftheria Kralli-Beller
  for manuscript editing. This research was supported by the Scientific Services Units
  (SSUs) of ISTA. We are particularly grateful for assistance from the Imaging and
  Optics Facility, Preclinical Facility, Lab Support Facility, and Miba Machine Shop.
  The project received funding from the European Research Council (ERC) under the
  European Union’s Horizon 2020 research and innovation program (grant agreement no.
  692692 to P.J., Marie Skłodowska-Curie Actions Individual Fellowship no. 101026635
  to J.F.W., and an ISTplus Fellowship through Marie Skłodowska-Curie grant agreement
  no. 754411 to V.V.-B.), the Austrian Science Fund (P 36232-B, PAT 4178023, and Cluster
  of Excellence 10.55776/COE16 to P.J.), and a CONACyT fellowship (289638 to V.V.-B.)
  and was supported by a non-stipendiary EMBO fellowship (ALTF 756–2020 to J.F.W.).
article_number: '116080'
article_processing_charge: Yes
article_type: original
author:
- first_name: Jake
  full_name: Watson, Jake
  id: 63836096-4690-11EA-BD4E-32803DDC885E
  last_name: Watson
  orcid: 0000-0002-8698-3823
- first_name: Victor M
  full_name: Vargas Barroso, Victor M
  id: 2F55A9DE-F248-11E8-B48F-1D18A9856A87
  last_name: Vargas Barroso
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
citation:
  ama: Watson J, Vargas Barroso VM, Jonas PM. Cell-specific wiring routes information
    flow through hippocampal CA3. <i>Cell Reports</i>. 2025;44(8). doi:<a href="https://doi.org/10.1016/j.celrep.2025.116080">10.1016/j.celrep.2025.116080</a>
  apa: Watson, J., Vargas Barroso, V. M., &#38; Jonas, P. M. (2025). Cell-specific
    wiring routes information flow through hippocampal CA3. <i>Cell Reports</i>. Elsevier.
    <a href="https://doi.org/10.1016/j.celrep.2025.116080">https://doi.org/10.1016/j.celrep.2025.116080</a>
  chicago: Watson, Jake, Victor M Vargas Barroso, and Peter M Jonas. “Cell-Specific
    Wiring Routes Information Flow through Hippocampal CA3.” <i>Cell Reports</i>.
    Elsevier, 2025. <a href="https://doi.org/10.1016/j.celrep.2025.116080">https://doi.org/10.1016/j.celrep.2025.116080</a>.
  ieee: J. Watson, V. M. Vargas Barroso, and P. M. Jonas, “Cell-specific wiring routes
    information flow through hippocampal CA3,” <i>Cell Reports</i>, vol. 44, no. 8.
    Elsevier, 2025.
  ista: Watson J, Vargas Barroso VM, Jonas PM. 2025. Cell-specific wiring routes information
    flow through hippocampal CA3. Cell Reports. 44(8), 116080.
  mla: Watson, Jake, et al. “Cell-Specific Wiring Routes Information Flow through
    Hippocampal CA3.” <i>Cell Reports</i>, vol. 44, no. 8, 116080, Elsevier, 2025,
    doi:<a href="https://doi.org/10.1016/j.celrep.2025.116080">10.1016/j.celrep.2025.116080</a>.
  short: J. Watson, V.M. Vargas Barroso, P.M. Jonas, Cell Reports 44 (2025).
corr_author: '1'
date_created: 2025-08-03T22:01:30Z
date_published: 2025-08-01T00:00:00Z
date_updated: 2026-09-16T06:58:59Z
day: '01'
ddc:
- '570'
department:
- _id: PeJo
doi: 10.1016/j.celrep.2025.116080
ec_funded: 1
external_id:
  isi:
  - '001544472300002'
file:
- access_level: open_access
  checksum: 556ff9760661ecd23949d75031043b1f
  content_type: application/pdf
  creator: dernst
  date_created: 2025-08-04T06:53:07Z
  date_updated: 2025-08-04T06:53:07Z
  file_id: '20106'
  file_name: 2025_CellReports_Watson.pdf
  file_size: 27695214
  relation: main_file
  success: 1
file_date_updated: 2025-08-04T06:53:07Z
fulldoi: https://doi.org/10.1016/j.celrep.2025.116080
has_accepted_license: '1'
intvolume: '        44'
isi: 1
issue: '8'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
project:
- _id: 25B7EB9E-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '692692'
  name: Biophysics and circuit function of a giant cortical glutamatergic synapse
- _id: fc2be41b-9c52-11eb-aca3-faa90aa144e9
  call_identifier: H2020
  grant_number: '101026635'
  name: Synaptic computations of the hippocampal CA3 circuitry
- _id: bd88be38-d553-11ed-ba76-81d5a70a6ef5
  grant_number: P36232
  name: Mechanisms of GABA release in hippocampal circuits
- _id: 260C2330-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '754411'
  name: ISTplus - Postdoctoral Fellowships
- _id: 0a6c8641-b036-11f1-bacf-e4eec62b5bb4
  grant_number: COE16
  name: Neuronal circuits in health and disease (Jonas)
publication: Cell Reports
publication_identifier:
  eissn:
  - 2211-1247
  issn:
  - 2639-1856
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Cell-specific wiring routes information flow through hippocampal CA3
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 44
year: '2025'
...