[{"article_processing_charge":"Yes (in subscription journal)","publication_identifier":{"eissn":["1546-1696"],"issn":["1087-0156"]},"tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"day":"01","department":[{"_id":"SaSi"},{"_id":"GaNo"},{"_id":"PeJo"},{"_id":"JoDa"},{"_id":"Bio"},{"_id":"RySh"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"title":"Imaging brain tissue architecture across millimeter to nanometer scales","_id":"14257","date_published":"2024-07-01T00:00:00Z","quality_controlled":"1","doi":"10.1038/s41587-023-01911-8","acknowledgement":"We thank J. Vorlaufer, N. Agudelo-Dueñas, W. Jahr and A. Wartak for microscope maintenance and troubleshooting; C. Kreuzinger, A. Freeman and I. Erber for technical assistance; and M. Tomschik for support with obtaining human samples. We gratefully acknowledge E. Miguel for setting up webKnossos and M. Šuplata for computational support and hardware control. We are grateful to R. Shigemoto and B. Bickel for generous support and M. Sixt and S. Boyd (Stanford University) for discussions and critical reading of the paper. PSD95-HaloTag mice were kindly provided by S. Grant (University of Edinburgh). We acknowledge expert support by Institute of Science and Technology Austria’s scientific computing, imaging and optics, preclinical and lab support facilities and by the Miba machine shop and library. We gratefully acknowledge funding by the following sources: Austrian Science Fund (FWF) grant I3600-B27 (J.G.D.); Austrian Science Fund (FWF) grant DK W1232 (J.G.D. and J.M.M.); Austrian Science Fund (FWF) grant Z 312-B27, Wittgenstein award (P.J.); Austrian Science Fund (FWF) projects I4685-B, I6565-B (SYNABS) and DOC 33-B27 (R.H.); Gesellschaft für Forschungsförderung NÖ (NFB) grant LSC18-022 (J.G.D.); European Union’s Horizon 2020 research and innovation programme, European Research Council (ERC) grant 715508 – REVERSEAUTISM (G.N.); European Union’s Horizon 2020 research and innovation programme, European Research Council (ERC) grant 692692 – GIANTSYN (P.J.); Marie Skłodowska-Curie Actions Fellowship GA no. 665385 under the EU Horizon 2020 program (J.M.M. and J.L.); and Marie Skłodowska-Curie Actions Individual Fellowship no. 101026635 under the EU Horizon 2020 program (J.F.W.).","isi":1,"file":[{"file_size":26065165,"success":1,"checksum":"57d5fafb16f02dcb9f7dddb1bd7e2a71","file_id":"18784","file_name":"2024_NatureBiotech_Michalska.pdf","date_updated":"2025-01-09T07:48:01Z","creator":"dernst","relation":"main_file","access_level":"open_access","content_type":"application/pdf","date_created":"2025-01-09T07:48:01Z"}],"publisher":"Springer Nature","pmid":1,"page":"1051-1064","acknowledged_ssus":[{"_id":"ScienComp"},{"_id":"Bio"},{"_id":"PreCl"},{"_id":"LifeSc"},{"_id":"M-Shop"},{"_id":"E-Lib"}],"author":[{"full_name":"Michalska, Julia M","id":"443DB6DE-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-3862-1235","first_name":"Julia M","last_name":"Michalska"},{"id":"46E28B80-F248-11E8-B48F-1D18A9856A87","full_name":"Lyudchik, Julia","last_name":"Lyudchik","first_name":"Julia"},{"full_name":"Velicky, Philipp","id":"39BDC62C-F248-11E8-B48F-1D18A9856A87","last_name":"Velicky","orcid":"0000-0002-2340-7431","first_name":"Philipp"},{"full_name":"Korinkova, Hana","id":"ee3cb6ca-ec98-11ea-ae11-ff703e2254ed","last_name":"Korinkova","first_name":"Hana"},{"id":"63836096-4690-11EA-BD4E-32803DDC885E","full_name":"Watson, Jake","last_name":"Watson","first_name":"Jake","orcid":"0000-0002-8698-3823"},{"first_name":"Alban","last_name":"Cenameri","full_name":"Cenameri, Alban","id":"9ac8f577-2357-11eb-997a-e566c5550886"},{"orcid":"0000-0003-1216-9105","first_name":"Christoph M","last_name":"Sommer","full_name":"Sommer, Christoph M","id":"4DF26D8C-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Amberg","first_name":"Nicole","orcid":"0000-0002-3183-8207","id":"4CD6AAC6-F248-11E8-B48F-1D18A9856A87","full_name":"Amberg, Nicole"},{"full_name":"Venturino, Alessandro","id":"41CB84B2-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-2356-9403","first_name":"Alessandro","last_name":"Venturino"},{"last_name":"Roessler","first_name":"Karl","full_name":"Roessler, Karl"},{"full_name":"Czech, Thomas","last_name":"Czech","first_name":"Thomas"},{"full_name":"Höftberger, Romana","first_name":"Romana","last_name":"Höftberger"},{"first_name":"Sandra","orcid":"0000-0001-8635-0877","last_name":"Siegert","id":"36ACD32E-F248-11E8-B48F-1D18A9856A87","full_name":"Siegert, Sandra"},{"full_name":"Novarino, Gaia","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","last_name":"Novarino","orcid":"0000-0002-7673-7178","first_name":"Gaia"},{"id":"353C1B58-F248-11E8-B48F-1D18A9856A87","full_name":"Jonas, Peter M","first_name":"Peter M","orcid":"0000-0001-5001-4804","last_name":"Jonas"},{"full_name":"Danzl, Johann G","id":"42EFD3B6-F248-11E8-B48F-1D18A9856A87","last_name":"Danzl","orcid":"0000-0001-8559-3973","first_name":"Johann G"}],"related_material":{"link":[{"relation":"software","url":"https://github.com/danzllab/CATS"}],"record":[{"relation":"dissertation_contains","status":"deleted","id":"18660"},{"relation":"research_data","status":"public","id":"13126"},{"id":"18674","status":"public","relation":"dissertation_contains"}]},"volume":42,"month":"07","year":"2024","publication_status":"published","file_date_updated":"2025-01-09T07:48:01Z","citation":{"chicago":"Michalska, Julia M, Julia Lyudchik, Philipp Velicky, Hana Korinkova, Jake Watson, Alban Cenameri, Christoph M Sommer, et al. “Imaging Brain Tissue Architecture across Millimeter to Nanometer Scales.” <i>Nature Biotechnology</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1038/s41587-023-01911-8\">https://doi.org/10.1038/s41587-023-01911-8</a>.","short":"J.M. Michalska, J. Lyudchik, P. Velicky, H. Korinkova, J. Watson, A. Cenameri, C.M. Sommer, N. Amberg, A. Venturino, K. Roessler, T. Czech, R. Höftberger, S. Siegert, G. Novarino, P.M. Jonas, J.G. Danzl, Nature Biotechnology 42 (2024) 1051–1064.","mla":"Michalska, Julia M., et al. “Imaging Brain Tissue Architecture across Millimeter to Nanometer Scales.” <i>Nature Biotechnology</i>, vol. 42, Springer Nature, 2024, pp. 1051–64, doi:<a href=\"https://doi.org/10.1038/s41587-023-01911-8\">10.1038/s41587-023-01911-8</a>.","ieee":"J. M. Michalska <i>et al.</i>, “Imaging brain tissue architecture across millimeter to nanometer scales,” <i>Nature Biotechnology</i>, vol. 42. Springer Nature, pp. 1051–1064, 2024.","ista":"Michalska JM, Lyudchik J, Velicky P, Korinkova H, Watson J, Cenameri A, Sommer CM, Amberg N, Venturino A, Roessler K, Czech T, Höftberger R, Siegert S, Novarino G, Jonas PM, Danzl JG. 2024. Imaging brain tissue architecture across millimeter to nanometer scales. Nature Biotechnology. 42, 1051–1064.","ama":"Michalska JM, Lyudchik J, Velicky P, et al. Imaging brain tissue architecture across millimeter to nanometer scales. <i>Nature Biotechnology</i>. 2024;42:1051-1064. doi:<a href=\"https://doi.org/10.1038/s41587-023-01911-8\">10.1038/s41587-023-01911-8</a>","apa":"Michalska, J. M., Lyudchik, J., Velicky, P., Korinkova, H., Watson, J., Cenameri, A., … Danzl, J. G. (2024). Imaging brain tissue architecture across millimeter to nanometer scales. <i>Nature Biotechnology</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41587-023-01911-8\">https://doi.org/10.1038/s41587-023-01911-8</a>"},"article_type":"original","ec_funded":1,"language":[{"iso":"eng"}],"publication":"Nature Biotechnology","scopus_import":"1","date_created":"2023-09-03T22:01:15Z","oa_version":"Published Version","type":"journal_article","corr_author":"1","abstract":[{"text":"Mapping the complex and dense arrangement of cells and their connectivity in brain tissue demands nanoscale spatial resolution imaging. Super-resolution optical microscopy excels at visualizing specific molecules and individual cells but fails to provide tissue context. Here we developed Comprehensive Analysis of Tissues across Scales (CATS), a technology to densely map brain tissue architecture from millimeter regional to nanometer synaptic scales in diverse chemically fixed brain preparations, including rodent and human. CATS uses fixation-compatible extracellular labeling and optical imaging, including stimulated emission depletion or expansion microscopy, to comprehensively delineate cellular structures. It enables three-dimensional reconstruction of single synapses and mapping of synaptic connectivity by identification and analysis of putative synaptic cleft regions. Applying CATS to the mouse hippocampal mossy fiber circuitry, we reconstructed and quantified the synaptic input and output structure of identified neurons. We furthermore demonstrate applicability to clinically derived human tissue samples, including formalin-fixed paraffin-embedded routine diagnostic specimens, for visualizing the cellular architecture of brain tissue in health and disease.","lang":"eng"}],"external_id":{"pmid":["37653226"],"isi":["001065254200001"]},"has_accepted_license":"1","status":"public","OA_type":"hybrid","project":[{"grant_number":"I03600","_id":"265CB4D0-B435-11E9-9278-68D0E5697425","name":"Optical control of synaptic function via adhesion molecules","call_identifier":"FWF"},{"grant_number":"W1232","_id":"2548AE96-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","name":"Molecular Drug Targets"},{"call_identifier":"FWF","_id":"25C5A090-B435-11E9-9278-68D0E5697425","name":"Synaptic communication in neuronal microcircuits","grant_number":"Z00312"},{"name":"High content imaging to decode human immune cell interactions in health and allergic disease","_id":"23889792-32DE-11EA-91FC-C7463DDC885E","grant_number":"LS18-022"},{"_id":"25444568-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"Probing the Reversibility of Autism Spectrum Disorders by Employing in vivo and in vitro Models","grant_number":"715508"},{"grant_number":"692692","_id":"25B7EB9E-B435-11E9-9278-68D0E5697425","name":"Biophysics and circuit function of a giant cortical glutamatergic synapse","call_identifier":"H2020"},{"call_identifier":"H2020","name":"International IST Doctoral Program","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","grant_number":"665385"},{"grant_number":"101026635","_id":"fc2be41b-9c52-11eb-aca3-faa90aa144e9","call_identifier":"H2020","name":"Synaptic computations of the hippocampal CA3 circuitry"}],"intvolume":"        42","OA_place":"publisher","date_updated":"2026-04-14T08:34:35Z","ddc":["570"]},{"article_processing_charge":"No","tmp":{"short":"CC BY-NC-SA (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode","image":"/images/cc_by_nc_sa.png","name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)"},"day":"04","department":[{"_id":"JoDa"},{"_id":"SaSi"},{"_id":"GaNo"},{"_id":"PeJo"},{"_id":"Bio"},{"_id":"RySh"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","license":"https://creativecommons.org/licenses/by-nc-sa/4.0/","title":"Research data for the publication \"Imaging brain tissue architecture across millimeter to nanometer scales\"","oa":1,"date_published":"2023-08-04T00:00:00Z","_id":"13126","doi":"10.15479/AT:ISTA:13126","file":[{"content_type":"text/plain","date_created":"2023-08-04T13:19:47Z","creator":"jdanzl","relation":"main_file","access_level":"open_access","success":1,"checksum":"6f18ce9b89b47ce5abeb379869ff5c49","file_id":"13961","file_name":"Readme_Michalska_2023.txt","date_updated":"2023-08-04T13:19:47Z","file_size":541},{"file_size":64582744,"success":1,"checksum":"2098e8c5285c5e86cb69075e1b5dcf39","file_id":"13482","file_name":"Fig1_b_top-left.tif","date_updated":"2023-08-03T11:29:29Z","creator":"jdanzl","relation":"main_file","access_level":"open_access","content_type":"image/tiff","date_created":"2023-08-03T11:29:29Z"},{"date_updated":"2023-08-03T11:29:28Z","file_id":"13483","file_name":"Fig1_b_top-right.tif","success":1,"checksum":"9affab3dacf847096cc8e8d5ff99467e","file_size":1442113,"content_type":"image/tiff","date_created":"2023-08-03T11:29:28Z","access_level":"open_access","relation":"main_file","creator":"jdanzl"},{"file_id":"13484","file_name":"Fig1_c_1.tif","date_updated":"2023-08-03T11:29:29Z","success":1,"checksum":"d7fec0296123a17f6bcdbfee17411424","file_size":40078276,"content_type":"image/tiff","date_created":"2023-08-03T11:29:29Z","access_level":"open_access","creator":"jdanzl","relation":"main_file"},{"access_level":"open_access","creator":"jdanzl","relation":"main_file","date_created":"2023-08-03T11:29:29Z","content_type":"image/tiff","file_size":7984315,"file_id":"13485","file_name":"Fig1_c_2.tif","date_updated":"2023-08-03T11:29:29Z","success":1,"checksum":"5195a180c4f26a7adc994bad0b3c53c7"},{"relation":"main_file","creator":"jdanzl","access_level":"open_access","date_created":"2023-08-03T11:29:29Z","content_type":"image/tiff","file_size":8693320,"success":1,"checksum":"df1105d8f41ebd5373cacc597ffa91f3","date_updated":"2023-08-03T11:29:29Z","file_id":"13486","file_name":"Fig1_c_3.tif"},{"file_size":6003063,"file_id":"13487","file_name":"Fig1_c_4.tif","date_updated":"2023-08-03T11:29:30Z","checksum":"00edbb0c9f42032c830d2291ec55c4c0","success":1,"access_level":"open_access","creator":"jdanzl","relation":"main_file","content_type":"image/tiff","date_created":"2023-08-03T11:29:30Z"},{"relation":"main_file","creator":"jdanzl","access_level":"open_access","content_type":"image/tiff","date_created":"2023-08-03T11:29:30Z","file_size":24003063,"success":1,"checksum":"a58399e98ec4b6506a5dae13e387f391","date_updated":"2023-08-03T11:29:30Z","file_id":"13488","file_name":"Fig1_d.tif"},{"date_created":"2023-08-03T11:29:30Z","content_type":"image/tiff","creator":"jdanzl","relation":"main_file","access_level":"open_access","success":1,"checksum":"699df4bc104df14607359678963b3d2d","file_id":"13489","file_name":"Fig1_e_zoom.tif","date_updated":"2023-08-03T11:29:30Z","file_size":18063},{"date_updated":"2023-08-03T11:29:30Z","file_id":"13490","file_name":"Fig1_e.tif","checksum":"ea7b1278da490d221fc7698fd6bc39a4","success":1,"file_size":186813,"content_type":"image/tiff","date_created":"2023-08-03T11:29:30Z","access_level":"open_access","relation":"main_file","creator":"jdanzl"},{"access_level":"open_access","relation":"main_file","creator":"jdanzl","content_type":"application/vnd.openxmlformats-officedocument.spreadsheetml.sheet","date_created":"2023-08-03T11:29:30Z","file_size":17494,"date_updated":"2023-08-03T11:29:30Z","file_name":"Fig1_f.xlsx","file_id":"13491","success":1,"checksum":"37b05ef3a36b9f6bf4ec46199230874a"},{"file_size":816786862,"checksum":"872eb3dc1a94afb26947a365bfae581a","success":1,"file_name":"Fig2_a_1.tif","file_id":"13492","date_updated":"2023-08-03T11:40:43Z","creator":"jdanzl","relation":"main_file","access_level":"open_access","content_type":"image/tiff","date_created":"2023-08-03T11:40:43Z"},{"access_level":"open_access","creator":"jdanzl","relation":"main_file","date_created":"2023-08-03T11:40:13Z","content_type":"image/tiff","file_size":8654692,"file_id":"13493","file_name":"Fig2_a_2.tif","date_updated":"2023-08-03T11:40:13Z","success":1,"checksum":"cab6f72d7d546a81c105c229747949ef"},{"content_type":"image/tiff","date_created":"2023-08-03T11:40:14Z","access_level":"open_access","relation":"main_file","creator":"jdanzl","date_updated":"2023-08-03T11:40:14Z","file_id":"13494","file_name":"Fig2_a_3.tif","success":1,"checksum":"c85bc3ffe7f6bdf16a81290761ed6253","file_size":8654692},{"file_id":"13495","file_name":"Fig2_a_4.tif","date_updated":"2023-08-03T11:40:24Z","checksum":"5a3fd5484e566c34e210a4acb2b97791","success":1,"file_size":272262438,"content_type":"image/tiff","date_created":"2023-08-03T11:40:24Z","access_level":"open_access","creator":"jdanzl","relation":"main_file"},{"file_size":272262438,"file_id":"13496","file_name":"Fig2_a_5.tif","date_updated":"2023-08-03T11:40:37Z","success":1,"checksum":"ae5cbacf56e3fdf934a6d6fd489f5fe0","access_level":"open_access","creator":"jdanzl","relation":"main_file","content_type":"image/tiff","date_created":"2023-08-03T11:40:37Z"},{"content_type":"image/tiff","date_created":"2023-08-03T11:40:44Z","access_level":"open_access","relation":"main_file","creator":"jdanzl","date_updated":"2023-08-03T11:40:44Z","file_id":"13497","file_name":"Fig2_a_6.tif","success":1,"checksum":"e6da436b83bbe3a34138b52e5de49d69","file_size":204301228},{"date_created":"2023-08-03T11:40:49Z","content_type":"image/tiff","creator":"jdanzl","relation":"main_file","access_level":"open_access","checksum":"855f0a0bcf5b3d7cc7d50561f2c8f625","success":1,"file_name":"Fig2_a_7-8.tif","file_id":"13498","date_updated":"2023-08-03T11:40:49Z","file_size":68094350},{"checksum":"ff709f9f8ebaa8cf50a4b2fca5ce9813","success":1,"file_id":"13499","file_name":"Fig2_a_roi.roi","date_updated":"2023-08-03T11:40:48Z","file_size":156,"date_created":"2023-08-03T11:40:48Z","content_type":"application/octet-stream","creator":"jdanzl","relation":"main_file","access_level":"open_access"},{"file_name":"Fig2_c-i_1_n2v.tif","file_id":"13500","date_updated":"2023-08-03T11:41:37Z","success":1,"checksum":"ce9b774ff5163ebfa4e3fb162f4cfffe","file_size":1036927887,"date_created":"2023-08-03T11:41:37Z","content_type":"image/tiff","access_level":"open_access","creator":"jdanzl","relation":"main_file"},{"file_size":518519275,"checksum":"21f1bb8d2a00c88bdd6febe6285acc2a","success":1,"file_id":"13501","file_name":"Fig2_c-i_1.tif","date_updated":"2023-08-03T11:41:25Z","creator":"jdanzl","relation":"main_file","access_level":"open_access","date_created":"2023-08-03T11:41:25Z","content_type":"image/tiff"},{"date_created":"2023-08-03T11:42:48Z","content_type":"image/tiff","access_level":"open_access","creator":"jdanzl","relation":"main_file","file_name":"Fig2_c-i_3_n2v.tif","file_id":"13502","date_updated":"2023-08-03T11:42:48Z","success":1,"checksum":"9af5b66b74c2ff4b2b99b0d94f2864e6","file_size":1444202302},{"creator":"jdanzl","relation":"main_file","access_level":"open_access","date_created":"2023-08-03T11:42:57Z","content_type":"image/tiff","file_size":1075338708,"checksum":"c83261e88821747b301197314d92f2b2","success":1,"file_id":"13503","file_name":"Fig2_c-i_3.tif","date_updated":"2023-08-03T11:42:57Z"},{"content_type":"image/tiff","date_created":"2023-08-03T11:44:05Z","creator":"jdanzl","relation":"main_file","access_level":"open_access","checksum":"5d1278ba4b7e085c0c186ea49fce535b","success":1,"file_id":"13504","file_name":"Fig2_c-i_2_n2v.tif","date_updated":"2023-08-03T11:44:05Z","file_size":851145493},{"creator":"jdanzl","relation":"main_file","access_level":"open_access","content_type":"image/tiff","date_created":"2023-08-03T11:43:47Z","file_size":432099834,"success":1,"checksum":"5aaf1eba65582cf437ff3ce753eba4d7","file_name":"Fig2_c-i_2.tif","file_id":"13505","date_updated":"2023-08-03T11:43:47Z"},{"success":1,"checksum":"ce9b774ff5163ebfa4e3fb162f4cfffe","date_updated":"2023-08-03T11:44:41Z","file_name":"Fig2_h_n2v.tif","file_id":"13506","file_size":1036927887,"content_type":"image/tiff","date_created":"2023-08-03T11:44:41Z","relation":"main_file","creator":"jdanzl","access_level":"open_access"},{"date_created":"2023-08-03T11:44:36Z","content_type":"image/tiff","relation":"main_file","creator":"jdanzl","access_level":"open_access","checksum":"21f1bb8d2a00c88bdd6febe6285acc2a","success":1,"date_updated":"2023-08-03T11:44:36Z","file_name":"Fig2_h.tif","file_id":"13507","file_size":518519275},{"content_type":"image/tiff","date_created":"2023-08-03T11:44:40Z","relation":"main_file","creator":"jdanzl","access_level":"open_access","success":1,"checksum":"b37f25a90ef42fa4358649fdd6b41f35","date_updated":"2023-08-03T11:44:40Z","file_id":"13508","file_name":"Fig2_j_1.tif","file_size":19287397},{"access_level":"open_access","creator":"jdanzl","relation":"main_file","content_type":"image/tiff","date_created":"2023-08-03T11:44:41Z","file_size":617552,"file_id":"13509","file_name":"Fig2_j_2.tif","date_updated":"2023-08-03T11:44:41Z","success":1,"checksum":"50f0969c6c2c1209ff776bec4861030a"},{"file_size":19287392,"file_name":"Fig2_j_3.tif","file_id":"13510","date_updated":"2023-08-03T11:44:41Z","success":1,"checksum":"2a8cc93471378ac4c3b640e4318d89eb","access_level":"open_access","creator":"jdanzl","relation":"main_file","date_created":"2023-08-03T11:44:41Z","content_type":"image/tiff"},{"creator":"jdanzl","relation":"main_file","access_level":"open_access","content_type":"image/tiff","date_created":"2023-08-03T11:44:42Z","file_size":617552,"checksum":"b90965d20133fea73c99050c32eb7695","success":1,"file_id":"13511","file_name":"Fig2_j_4.tif","date_updated":"2023-08-03T11:44:42Z"},{"file_size":19287339,"file_id":"13512","file_name":"Fig2_j_coCATS_N2V.tif","date_updated":"2023-08-03T11:44:43Z","success":1,"checksum":"568a1e0efaa62527b51e66a7aabfd05c","access_level":"open_access","creator":"jdanzl","relation":"main_file","content_type":"image/tiff","date_created":"2023-08-03T11:44:43Z"},{"file_size":148,"date_updated":"2023-08-03T11:44:44Z","file_name":"Fig2_j_roi.roi","file_id":"13513","success":1,"checksum":"c70447cebe073dd78e0ac34ecc36ad85","access_level":"open_access","relation":"main_file","creator":"jdanzl","date_created":"2023-08-03T11:44:44Z","content_type":"application/octet-stream"},{"success":1,"checksum":"505252cc4b443b76c2e41ecf5879a542","date_updated":"2023-08-03T11:44:52Z","file_name":"Fig3_a_n2v.tif","file_id":"13514","file_size":316842690,"date_created":"2023-08-03T11:44:52Z","content_type":"image/tiff","relation":"main_file","creator":"jdanzl","access_level":"open_access"},{"checksum":"35463183611e8ee4fba2025772c40eb2","success":1,"file_name":"Fig3_a.tif","file_id":"13515","date_updated":"2023-08-03T11:45:01Z","file_size":172839057,"content_type":"image/tiff","date_created":"2023-08-03T11:45:01Z","creator":"jdanzl","relation":"main_file","access_level":"open_access"},{"access_level":"open_access","relation":"main_file","creator":"jdanzl","content_type":"image/tiff","date_created":"2023-08-03T11:45:05Z","file_size":309407894,"date_updated":"2023-08-03T11:45:05Z","file_name":"Fig3_g_n2v.tif","file_id":"13516","checksum":"e0469102a87332b46904b4ba35b8fb2f","success":1},{"file_name":"Fig4_a_MIP.tif","file_id":"13517","date_updated":"2023-08-03T11:51:15Z","success":1,"checksum":"854c8fe02acd920f8e8f6a3173458e86","file_size":11327792,"content_type":"image/tiff","date_created":"2023-08-03T11:51:15Z","access_level":"open_access","creator":"jdanzl","relation":"main_file"},{"file_size":106696700,"date_updated":"2023-08-03T11:51:18Z","file_name":"Fig4_c_dghilus_bouton2_n2v.tif","file_id":"13518","checksum":"ab35811ffbe3f40733d0e054d9d6c4e6","success":1,"access_level":"open_access","relation":"main_file","creator":"jdanzl","date_created":"2023-08-03T11:51:18Z","content_type":"image/tiff"},{"content_type":"image/tiff","date_created":"2023-08-03T11:51:17Z","relation":"main_file","creator":"jdanzl","access_level":"open_access","success":1,"checksum":"e3b6410d68e42004ef3857967707aeb3","date_updated":"2023-08-03T11:51:17Z","file_id":"13519","file_name":"Fig4_c_dghilus_bouton2.tif","file_size":53367287},{"success":1,"checksum":"9ef0e3f3ec6f0b7b2666e3a0d7e6f355","date_updated":"2023-08-03T11:51:20Z","file_name":"Fig4_c_dghilus_bouton5_n2v.tif","file_id":"13520","file_size":103816699,"content_type":"image/tiff","date_created":"2023-08-03T11:51:20Z","relation":"main_file","creator":"jdanzl","access_level":"open_access"},{"creator":"jdanzl","relation":"main_file","access_level":"open_access","date_created":"2023-08-03T11:51:21Z","content_type":"image/tiff","file_size":51927287,"checksum":"d5d846a4edaf0168ca6cc53d8cc39dde","success":1,"file_id":"13521","file_name":"Fig4_c_dghilus_bouton5.tif","date_updated":"2023-08-03T11:51:21Z"},{"creator":"jdanzl","relation":"main_file","access_level":"open_access","date_created":"2023-08-03T11:51:24Z","content_type":"image/tiff","file_size":76391971,"success":1,"checksum":"690a87182441c9742da2550189641e5a","file_id":"13522","file_name":"Fig4_c_stratum_bouton11_n2v.tif","date_updated":"2023-08-03T11:51:24Z"},{"checksum":"4dc575424729c5ba181bd9a3962d4781","success":1,"date_updated":"2023-08-03T11:51:23Z","file_name":"Fig4_c_stratum_bouton11.tif","file_id":"13523","file_size":38217920,"date_created":"2023-08-03T11:51:23Z","content_type":"image/tiff","relation":"main_file","creator":"jdanzl","access_level":"open_access"},{"file_size":154149020,"file_name":"Fig4_c_stratum_bouton13_n2v.tif","file_id":"13524","date_updated":"2023-08-03T11:51:29Z","checksum":"9fdd51636928f45e8e534cc5a37a48ff","success":1,"access_level":"open_access","creator":"jdanzl","relation":"main_file","date_created":"2023-08-03T11:51:29Z","content_type":"image/tiff"},{"file_size":77099447,"file_id":"13525","file_name":"Fig4_c_stratum_bouton13.tif","date_updated":"2023-08-03T11:51:28Z","success":1,"checksum":"643169464252d67753ac6f8493668f34","access_level":"open_access","creator":"jdanzl","relation":"main_file","date_created":"2023-08-03T11:51:28Z","content_type":"image/tiff"},{"content_type":"image/tiff","date_created":"2023-08-03T11:51:32Z","access_level":"open_access","relation":"main_file","creator":"jdanzl","date_updated":"2023-08-03T11:51:32Z","file_id":"13526","file_name":"Fig4_d.tif","checksum":"ab35811ffbe3f40733d0e054d9d6c4e6","success":1,"file_size":106696700},{"content_type":"image/tiff","date_created":"2023-08-03T11:51:35Z","access_level":"open_access","creator":"jdanzl","relation":"main_file","file_name":"Fig4_e.tif","file_id":"13527","date_updated":"2023-08-03T11:51:35Z","success":1,"checksum":"9fdd51636928f45e8e534cc5a37a48ff","file_size":154149020},{"access_level":"open_access","creator":"jdanzl","relation":"main_file","date_created":"2023-08-03T11:51:32Z","content_type":"image/tiff","file_size":5986760,"file_name":"Fig4_f_1_top.tif","file_id":"13528","date_updated":"2023-08-03T11:51:32Z","success":1,"checksum":"5380d0a98e97d7d8462b38bd0a96644c"},{"file_size":6001178,"file_id":"13529","file_name":"Fig4_f_2_top.tif","date_updated":"2023-08-03T11:51:33Z","success":1,"checksum":"7d1309e806eb31588ebafcf40388e13f","access_level":"open_access","creator":"jdanzl","relation":"main_file","date_created":"2023-08-03T11:51:33Z","content_type":"image/tiff"},{"success":1,"checksum":"a71c80207655d508cbc7626bc144d7a1","date_updated":"2023-08-03T11:51:33Z","file_name":"Fig4_f_3_top.tif","file_id":"13530","file_size":6023318,"date_created":"2023-08-03T11:51:33Z","content_type":"image/tiff","relation":"main_file","creator":"jdanzl","access_level":"open_access"},{"date_updated":"2023-08-03T11:51:34Z","file_id":"13531","file_name":"Fig4_f_4_top.tif","checksum":"5d76b2ad7d7acbb1afa27cf52194b1cb","success":1,"file_size":6038186,"content_type":"image/tiff","date_created":"2023-08-03T11:51:34Z","access_level":"open_access","relation":"main_file","creator":"jdanzl"},{"checksum":"9cee6b3387bd880843f2c6cdfa0d4a8d","success":1,"file_name":"Fig4_f_5_top.tif","file_id":"13532","date_updated":"2023-08-03T11:51:34Z","file_size":2324158,"content_type":"image/tiff","date_created":"2023-08-03T11:51:34Z","creator":"jdanzl","relation":"main_file","access_level":"open_access"},{"access_level":"open_access","creator":"jdanzl","relation":"main_file","date_created":"2023-08-03T11:51:34Z","content_type":"image/png","file_size":1150264,"file_name":"Fig4_f_1_bottom.png","file_id":"13533","date_updated":"2023-08-03T11:51:34Z","checksum":"a48fc9e1bb2710cf28466ae6d2a20c19","success":1},{"content_type":"image/png","date_created":"2023-08-03T11:51:34Z","access_level":"open_access","relation":"main_file","creator":"jdanzl","date_updated":"2023-08-03T11:51:34Z","file_id":"13534","file_name":"Fig4_f_2_bottom.png","success":1,"checksum":"ff47ca30f814e17561974b73b0913a1a","file_size":1157424},{"checksum":"2ea3fb8d79cee8ae9de7ca31d003910f","success":1,"date_updated":"2023-08-03T11:51:34Z","file_id":"13535","file_name":"Fig4_f_3_bottom.png","file_size":1152715,"date_created":"2023-08-03T11:51:34Z","content_type":"image/png","relation":"main_file","creator":"jdanzl","access_level":"open_access"},{"creator":"jdanzl","relation":"main_file","access_level":"open_access","date_created":"2023-08-03T11:51:34Z","content_type":"image/png","file_size":1105240,"success":1,"checksum":"d25e5ecf2f0c3be7c20a7e25a7a334b8","file_id":"13536","file_name":"Fig4_f_4_bottom.png","date_updated":"2023-08-03T11:51:34Z"},{"success":1,"checksum":"76535f569a57b967e378df89b7d2982a","file_name":"Fig4_f_5_bottom.png","file_id":"13537","date_updated":"2023-08-03T11:51:35Z","file_size":1228157,"content_type":"image/png","date_created":"2023-08-03T11:51:35Z","creator":"jdanzl","relation":"main_file","access_level":"open_access"},{"success":1,"checksum":"d46fefe73daa3ec08b847631e9de6828","date_updated":"2023-08-03T11:53:52Z","file_id":"13538","file_name":"Fig5_a_1.tif","file_size":91181184,"date_created":"2023-08-03T11:53:52Z","content_type":"image/tiff","relation":"main_file","creator":"jdanzl","access_level":"open_access"},{"access_level":"open_access","relation":"main_file","creator":"jdanzl","date_created":"2023-08-03T11:53:54Z","content_type":"image/tiff","file_size":176024124,"date_updated":"2023-08-03T11:53:54Z","file_id":"13539","file_name":"Fig5_a_2.tif","checksum":"354c0ba876a33672eca37cd61dac7073","success":1},{"file_size":15812494,"date_updated":"2023-08-03T11:53:53Z","file_id":"13540","file_name":"Fig5_a_3.tif","success":1,"checksum":"d07925040ef0c3c51edbdca8cf3ec1fa","access_level":"open_access","relation":"main_file","creator":"jdanzl","content_type":"image/tiff","date_created":"2023-08-03T11:53:53Z"},{"success":1,"checksum":"7c34b19a1764e2f501f11dcabd442ce2","file_name":"Fig5_a_4.tif","file_id":"13541","date_updated":"2023-08-03T11:53:53Z","file_size":11117689,"date_created":"2023-08-03T11:53:53Z","content_type":"image/tiff","creator":"jdanzl","relation":"main_file","access_level":"open_access"},{"file_size":111665,"file_id":"13542","file_name":"Fig5_a_5.tif","date_updated":"2023-08-03T11:53:53Z","success":1,"checksum":"c49af4b96532e00b3a51574a2a94decb","access_level":"open_access","creator":"jdanzl","relation":"main_file","content_type":"image/tiff","date_created":"2023-08-03T11:53:53Z"},{"checksum":"1b42eadcdd71f2dc00d82784673aa577","success":1,"file_name":"Fig5_b_1.tif","file_id":"13543","date_updated":"2023-08-03T11:53:54Z","file_size":16676449,"date_created":"2023-08-03T11:53:54Z","content_type":"image/tiff","creator":"jdanzl","relation":"main_file","access_level":"open_access"},{"content_type":"image/tiff","date_created":"2023-08-03T11:53:54Z","relation":"main_file","creator":"jdanzl","access_level":"open_access","success":1,"checksum":"0d27266bf216f71fcb5496731ce76dd5","date_updated":"2023-08-03T11:53:54Z","file_name":"Fig5_b_2-4.tif","file_id":"13544","file_size":427651},{"date_updated":"2023-08-03T11:53:55Z","file_name":"Fig5_c_1-3.tif","file_id":"13545","success":1,"checksum":"c4232930068a0a8f7c8a70ce0ea48dc2","file_size":11117705,"content_type":"image/tiff","date_created":"2023-08-03T11:53:55Z","access_level":"open_access","relation":"main_file","creator":"jdanzl"},{"success":1,"checksum":"c9caad749be0ef04ef8013cfdb69f8fc","date_updated":"2023-08-03T11:53:55Z","file_name":"Fig5_c_2-4.tif","file_id":"13546","file_size":254153,"date_created":"2023-08-03T11:53:55Z","content_type":"image/tiff","relation":"main_file","creator":"jdanzl","access_level":"open_access"},{"file_id":"13547","file_name":"Fig5_e_1.tif","date_updated":"2023-08-03T11:54:14Z","success":1,"checksum":"5c6d36b96bde1e090cc428b269aba6ec","file_size":737290746,"date_created":"2023-08-03T11:54:14Z","content_type":"image/tiff","access_level":"open_access","creator":"jdanzl","relation":"main_file"},{"content_type":"image/tiff","date_created":"2023-08-03T11:53:57Z","creator":"jdanzl","relation":"main_file","access_level":"open_access","checksum":"f97632984b6a73e06cc0c8c947cdcc71","success":1,"file_id":"13548","file_name":"Fig5_e_2.tif","date_updated":"2023-08-03T11:53:57Z","file_size":31366288},{"success":1,"checksum":"8c471eeaa59008eed9e91afe5e1f1698","date_updated":"2023-08-03T11:53:57Z","file_id":"13549","file_name":"Fig5_e_3.tif","file_size":1216304,"date_created":"2023-08-03T11:53:57Z","content_type":"image/tiff","relation":"main_file","creator":"jdanzl","access_level":"open_access"},{"creator":"jdanzl","relation":"main_file","access_level":"open_access","date_created":"2023-08-03T11:53:59Z","content_type":"image/tiff","file_size":35669193,"success":1,"checksum":"31c10c3a1d874b5028e35e2dd8800a68","file_id":"13550","file_name":"Fig5_g.tif","date_updated":"2023-08-03T11:53:59Z"},{"file_size":7492349,"success":1,"checksum":"0e9fe7b7ee06a630837e9d3c41b80e01","file_name":"Fig5_h.tif","file_id":"13551","date_updated":"2023-08-03T11:53:59Z","creator":"jdanzl","relation":"main_file","access_level":"open_access","date_created":"2023-08-03T11:53:59Z","content_type":"image/tiff"},{"access_level":"open_access","relation":"main_file","creator":"jdanzl","date_created":"2023-08-03T11:59:18Z","content_type":"image/tiff","file_size":121446390,"date_updated":"2023-08-03T11:59:18Z","file_id":"13552","file_name":"Fig6_a_1.tif","checksum":"d25b3d04bb8364089cafdf8deb6846b6","success":1},{"file_name":"Fig6_a_2.tif","file_id":"13553","date_updated":"2023-08-03T11:59:22Z","success":1,"checksum":"4361e10db6ec48c2d4579ac089ff3ca3","file_size":264412158,"content_type":"image/tiff","date_created":"2023-08-03T11:59:22Z","access_level":"open_access","creator":"jdanzl","relation":"main_file"},{"file_name":"Fig6_a_3.tif","file_id":"13554","date_updated":"2023-08-03T11:59:21Z","success":1,"checksum":"fe3a00ae75fb3388438e53ced92a9498","file_size":57399051,"date_created":"2023-08-03T11:59:21Z","content_type":"image/tiff","access_level":"open_access","creator":"jdanzl","relation":"main_file"},{"access_level":"open_access","relation":"main_file","creator":"jdanzl","date_created":"2023-08-03T11:59:21Z","content_type":"image/tiff","file_size":6003163,"date_updated":"2023-08-03T11:59:21Z","file_name":"Fig6_b_left.tif","file_id":"13555","success":1,"checksum":"4372c13d6dd2274aa749799b8e96bf06"},{"file_size":511265,"date_updated":"2023-08-03T11:59:21Z","file_name":"Fig6_b_right.tif","file_id":"13556","success":1,"checksum":"f7ae4e50f2f4d414c598bddd691b722a","access_level":"open_access","relation":"main_file","creator":"jdanzl","content_type":"image/tiff","date_created":"2023-08-03T11:59:21Z"},{"success":1,"checksum":"cde658a9ca666bdef1b29613ab72092d","date_updated":"2023-08-03T11:59:39Z","file_id":"13557","file_name":"Fig6_c_n2v.tif","file_size":467125933,"content_type":"image/tiff","date_created":"2023-08-03T11:59:39Z","relation":"main_file","creator":"jdanzl","access_level":"open_access"},{"checksum":"57e73c1fedcee4bd8ab62518baa0e0e5","success":1,"file_name":"Fig6_c.tif","file_id":"13558","date_updated":"2023-08-03T11:59:36Z","file_size":322251440,"date_created":"2023-08-03T11:59:36Z","content_type":"image/tiff","creator":"jdanzl","relation":"main_file","access_level":"open_access"},{"date_updated":"2023-08-03T11:59:38Z","file_id":"13559","file_name":"Fig6_d_1.tif","success":1,"checksum":"53175073b83ab569241ae64ef7f180b3","file_size":37641738,"date_created":"2023-08-03T11:59:38Z","content_type":"image/tiff","access_level":"open_access","relation":"main_file","creator":"jdanzl"},{"access_level":"open_access","relation":"main_file","creator":"jdanzl","content_type":"image/tiff","date_created":"2023-08-03T11:59:40Z","file_size":70596929,"date_updated":"2023-08-03T11:59:40Z","file_name":"Fig6_d_2.tif","file_id":"13560","success":1,"checksum":"af97423e1077af85465a5e39fa25d1e4"},{"relation":"main_file","creator":"jdanzl","access_level":"open_access","date_created":"2023-08-03T11:59:42Z","content_type":"image/tiff","file_size":15303146,"success":1,"checksum":"f1fd7a9fa2a12a930fe35bdf53ba3ff7","date_updated":"2023-08-03T11:59:42Z","file_name":"Fig6_d_3.tif","file_id":"13561"},{"access_level":"open_access","relation":"main_file","creator":"jdanzl","date_created":"2023-08-03T11:59:41Z","content_type":"image/tiff","file_size":893051,"date_updated":"2023-08-03T11:59:41Z","file_id":"13562","file_name":"Fig6_d_4.tif","success":1,"checksum":"95655df5cdb05f09912298de9a3711b4"},{"access_level":"open_access","creator":"jdanzl","relation":"main_file","date_created":"2023-08-03T11:59:58Z","content_type":"image/tiff","file_size":381232200,"file_name":"Fig6_e.tif","file_id":"13563","date_updated":"2023-08-03T11:59:58Z","success":1,"checksum":"4d722b4e09ce617252d284f78ea2ee30"},{"file_size":345804470,"date_updated":"2023-08-03T11:59:58Z","file_id":"13564","file_name":"Fig6_f.tif","checksum":"d1eda9599f422a614404dd112f0c3185","success":1,"access_level":"open_access","relation":"main_file","creator":"jdanzl","date_created":"2023-08-03T11:59:58Z","content_type":"image/tiff"},{"file_id":"13565","file_name":"Fig6_g.tif","date_updated":"2023-08-03T12:00:08Z","checksum":"1cd202570f964b78e1f55c987d5d5de1","success":1,"file_size":346119927,"content_type":"image/tiff","date_created":"2023-08-03T12:00:08Z","access_level":"open_access","creator":"jdanzl","relation":"main_file"},{"date_updated":"2023-08-03T12:00:02Z","file_id":"13566","file_name":"Fig6_h.tif","success":1,"checksum":"78cbf1906ff8746ed524c62f8f580f52","file_size":7064977,"date_created":"2023-08-03T12:00:02Z","content_type":"image/tiff","access_level":"open_access","relation":"main_file","creator":"jdanzl"},{"date_created":"2023-08-03T12:00:03Z","content_type":"image/tiff","relation":"main_file","creator":"jdanzl","access_level":"open_access","checksum":"21635ce59f1ae5a334aaad3f4c0b171c","success":1,"date_updated":"2023-08-03T12:00:03Z","file_id":"13567","file_name":"Fig6_i.tif","file_size":7110129},{"content_type":"image/tiff","date_created":"2023-08-03T12:00:07Z","creator":"jdanzl","relation":"main_file","access_level":"open_access","success":1,"checksum":"704962856f2a024ce1f321a1785556e3","file_name":"Fig6_j.tif","file_id":"13568","date_updated":"2023-08-03T12:00:07Z","file_size":110297540},{"file_size":11117689,"file_name":"Fig6_k.tif","file_id":"13569","date_updated":"2023-08-03T12:00:07Z","checksum":"4b74ba5ae1e2bb2201bf51c74d733268","success":1,"access_level":"open_access","creator":"jdanzl","relation":"main_file","date_created":"2023-08-03T12:00:07Z","content_type":"image/tiff"},{"access_level":"open_access","relation":"main_file","creator":"jdanzl","date_created":"2023-08-03T12:05:41Z","content_type":"image/tiff","file_size":1287107,"date_updated":"2023-08-03T12:05:41Z","file_name":"Extdata_01_a_1.tif","file_id":"13570","success":1,"checksum":"a8efa3007df4e9e0f80c7a2bbc451178"},{"relation":"main_file","creator":"jdanzl","access_level":"open_access","content_type":"image/tiff","date_created":"2023-08-03T12:05:41Z","file_size":58307,"success":1,"checksum":"7f24b6c84ce96a67347eb5ef4c43fac1","date_updated":"2023-08-03T12:05:41Z","file_id":"13571","file_name":"Extdata_01_a_2.tif"},{"file_size":1283209,"file_id":"13572","file_name":"Extdata_01_a_3.tif","date_updated":"2023-08-03T12:05:41Z","success":1,"checksum":"fa7ae4eefc11b9b60c4ab80f6e839b73","access_level":"open_access","creator":"jdanzl","relation":"main_file","content_type":"image/tiff","date_created":"2023-08-03T12:05:41Z"},{"file_size":54409,"checksum":"cec9a5eb87f1b56e64626a00c6d0e53d","success":1,"file_name":"Extdata_01_a_4.tif","file_id":"13573","date_updated":"2023-08-03T12:05:41Z","creator":"jdanzl","relation":"main_file","access_level":"open_access","date_created":"2023-08-03T12:05:41Z","content_type":"image/tiff"},{"file_id":"13574","file_name":"Extdata_01_c_1.png","date_updated":"2023-08-03T12:05:41Z","success":1,"checksum":"450e4786d66d5059028420153908a4dc","file_size":2431,"date_created":"2023-08-03T12:05:41Z","content_type":"image/png","access_level":"open_access","creator":"jdanzl","relation":"main_file"},{"content_type":"image/png","date_created":"2023-08-03T12:05:41Z","access_level":"open_access","creator":"jdanzl","relation":"main_file","file_name":"Extdata_01_c_2.png","file_id":"13575","date_updated":"2023-08-03T12:05:41Z","success":1,"checksum":"feb758609b399cf644dd3ae7cd75fb96","file_size":612},{"file_size":433981,"file_id":"13576","file_name":"Extdata_01_d_1.tif","date_updated":"2023-08-03T12:05:41Z","checksum":"52f43300a50f83f9a6ff1409324086ee","success":1,"access_level":"open_access","creator":"jdanzl","relation":"main_file","content_type":"image/tiff","date_created":"2023-08-03T12:05:41Z"},{"checksum":"28925dcf8792f524e286beb16b0c532c","success":1,"file_name":"Extdata_01_d_2.tif","file_id":"13577","date_updated":"2023-08-03T12:05:41Z","file_size":19649,"content_type":"image/tiff","date_created":"2023-08-03T12:05:41Z","creator":"jdanzl","relation":"main_file","access_level":"open_access"},{"content_type":"image/tiff","date_created":"2023-08-03T12:05:41Z","creator":"jdanzl","relation":"main_file","access_level":"open_access","checksum":"c93b2f0426c80d18e252435f1e146568","success":1,"file_id":"13578","file_name":"Extdata_01_d_3.tif","date_updated":"2023-08-03T12:05:41Z","file_size":433981},{"file_size":19649,"checksum":"c0ed722a768001431f47646ef98c44da","success":1,"date_updated":"2023-08-03T12:05:41Z","file_name":"Extdata_01_d_4.tif","file_id":"13579","relation":"main_file","creator":"jdanzl","access_level":"open_access","date_created":"2023-08-03T12:05:41Z","content_type":"image/tiff"},{"file_size":4752,"checksum":"db9d386276b985b8e702f797e910bd0b","success":1,"date_updated":"2023-08-03T12:05:41Z","file_id":"13580","file_name":"Extdata_01_f_1.png","relation":"main_file","creator":"jdanzl","access_level":"open_access","date_created":"2023-08-03T12:05:41Z","content_type":"image/png"},{"content_type":"image/png","date_created":"2023-08-03T12:05:41Z","access_level":"open_access","relation":"main_file","creator":"jdanzl","date_updated":"2023-08-03T12:05:41Z","file_name":"Extdata_01_f_2.png","file_id":"13581","success":1,"checksum":"244f6645d191c50d997c0dc6a15535ec","file_size":2698},{"file_name":"Extdata_02_a.tif","file_id":"13582","date_updated":"2023-08-03T12:07:27Z","checksum":"3d6100b836d850b38e66e0f5a7919495","success":1,"file_size":24003247,"date_created":"2023-08-03T12:07:27Z","content_type":"image/tiff","access_level":"open_access","creator":"jdanzl","relation":"main_file"},{"file_size":1164723,"success":1,"checksum":"3cd6a3b7bf2061cf5c7810c0001236e5","file_id":"13583","file_name":"Extdata_02_b.tif","date_updated":"2023-08-03T12:07:27Z","creator":"jdanzl","relation":"main_file","access_level":"open_access","date_created":"2023-08-03T12:07:27Z","content_type":"image/tiff"},{"file_size":7109763,"checksum":"d87c82d663ffea379cc86c56981e2e16","success":1,"date_updated":"2023-08-03T12:10:32Z","file_id":"13584","file_name":"Extdata_03_SYPH1_xy_1.tif","relation":"main_file","creator":"jdanzl","access_level":"open_access","content_type":"image/tiff","date_created":"2023-08-03T12:10:32Z"},{"date_created":"2023-08-03T12:10:32Z","content_type":"image/tiff","creator":"jdanzl","relation":"main_file","access_level":"open_access","checksum":"a3703d0d26393578d4ba466681fc6be8","success":1,"file_name":"Extdata_03_SYPH1_xz_1-2.tif","file_id":"13585","date_updated":"2023-08-03T12:10:32Z","file_size":27791},{"access_level":"open_access","creator":"jdanzl","relation":"main_file","date_created":"2023-08-03T12:10:32Z","content_type":"image/tiff","file_size":27721,"file_name":"Extdata_03_SYPH1_xz_3-4.tif","file_id":"13586","date_updated":"2023-08-03T12:10:32Z","success":1,"checksum":"f653ac7d531cf9896cbd6a9edf2a7759"},{"access_level":"open_access","creator":"jdanzl","relation":"main_file","content_type":"image/tiff","date_created":"2023-08-03T12:10:33Z","file_size":57657482,"file_name":"Extdata_03_SYPH1_xz_n2v.tif","file_id":"13587","date_updated":"2023-08-03T12:10:33Z","success":1,"checksum":"04edbb337df4d5470e033a4f53c07300"},{"file_size":57657527,"success":1,"checksum":"09e1fe2dd3a1e8349693fda55d0985ca","file_id":"13588","file_name":"Extdata_03_SYPH1_xz.tif","date_updated":"2023-08-03T12:10:34Z","creator":"jdanzl","relation":"main_file","access_level":"open_access","date_created":"2023-08-03T12:10:34Z","content_type":"image/tiff"},{"success":1,"checksum":"458f8d486cb63876c6664cde4a9be27c","file_name":"Extdata_03_SYP1_xy_1.tif","file_id":"13589","date_updated":"2023-08-03T12:12:25Z","file_size":7109763,"date_created":"2023-08-03T12:12:25Z","content_type":"image/tiff","creator":"jdanzl","relation":"main_file","access_level":"open_access"},{"relation":"main_file","creator":"jdanzl","access_level":"open_access","date_created":"2023-08-03T12:12:25Z","content_type":"image/tiff","file_size":72963,"success":1,"checksum":"e2dfccc882d85b660d65a596e1a8cbac","date_updated":"2023-08-03T12:12:25Z","file_name":"Extdata_03_SYP1_xy_2-3.tif","file_id":"13590"},{"creator":"jdanzl","relation":"main_file","access_level":"open_access","date_created":"2023-08-03T12:12:25Z","content_type":"image/tiff","file_size":27724,"success":1,"checksum":"a331be6052c68cc027cdb79f15447d9a","file_name":"Extdata_03_SYP1_xz_1-2.tif","file_id":"13591","date_updated":"2023-08-03T12:12:25Z"},{"access_level":"open_access","relation":"main_file","creator":"jdanzl","content_type":"image/tiff","date_created":"2023-08-03T12:12:25Z","file_size":27724,"date_updated":"2023-08-03T12:12:25Z","file_id":"13592","file_name":"Extdata_03_SYP1_xz_3-4.tif","checksum":"4de626b035b43feaacd923fca411e6a2","success":1},{"file_name":"Extdata_03_SYP1_xz_n2v.tif","file_id":"13593","date_updated":"2023-08-03T12:12:30Z","checksum":"d8076e927a074f024924d9bdb6fdd5e6","success":1,"file_size":214613644,"date_created":"2023-08-03T12:12:30Z","content_type":"image/tiff","access_level":"open_access","creator":"jdanzl","relation":"main_file"},{"file_name":"Extdata_03_SYP1_xz.tif","file_id":"13594","date_updated":"2023-08-03T12:12:30Z","checksum":"79cf7d0f450c397caa877dd06b52f8df","success":1,"file_size":214613687,"content_type":"image/tiff","date_created":"2023-08-03T12:12:30Z","access_level":"open_access","creator":"jdanzl","relation":"main_file"},{"file_size":7109747,"success":1,"checksum":"60ac6ea988d9b8bdaba2f09e0e1ef370","file_id":"13595","file_name":"Extdata03_VAMP2_xy_1.tif","date_updated":"2023-08-03T12:14:29Z","creator":"jdanzl","relation":"main_file","access_level":"open_access","content_type":"image/tiff","date_created":"2023-08-03T12:14:29Z"},{"date_created":"2023-08-03T12:14:29Z","content_type":"image/tiff","creator":"jdanzl","relation":"main_file","access_level":"open_access","checksum":"92bf312da2dd356aa4fc9a0e7d811af2","success":1,"file_id":"13596","file_name":"Extdata03_VAMP2_xy_2-3.tif","date_updated":"2023-08-03T12:14:29Z","file_size":72947},{"checksum":"9319e293092eeee24e3c658fc178af1a","success":1,"date_updated":"2023-08-03T12:14:29Z","file_name":"Extdata03_VAMP2_xz_1-2.tif","file_id":"13597","file_size":27724,"content_type":"image/tiff","date_created":"2023-08-03T12:14:29Z","relation":"main_file","creator":"jdanzl","access_level":"open_access"},{"success":1,"checksum":"a627d7fd9a89bdde968e6d9bff846254","file_name":"Extdata03_VAMP2_xz_3-4.tif","file_id":"13598","date_updated":"2023-08-03T12:14:29Z","file_size":27708,"content_type":"image/tiff","date_created":"2023-08-03T12:14:29Z","creator":"jdanzl","relation":"main_file","access_level":"open_access"},{"file_name":"Extdata03_VAMP2_xz_n2v.tif","file_id":"13599","date_updated":"2023-08-03T12:14:32Z","success":1,"checksum":"7a5363a185edce59ce57535f7d855092","file_size":102457485,"date_created":"2023-08-03T12:14:32Z","content_type":"image/tiff","access_level":"open_access","creator":"jdanzl","relation":"main_file"},{"date_created":"2023-08-03T12:14:32Z","content_type":"image/tiff","creator":"jdanzl","relation":"main_file","access_level":"open_access","checksum":"8e7fc4d00fff8ec6d9340e969f37e176","success":1,"file_id":"13600","file_name":"Extdata03_VAMP2_xz.tif","date_updated":"2023-08-03T12:14:32Z","file_size":102457527},{"content_type":"image/tiff","date_created":"2023-08-03T12:16:08Z","access_level":"open_access","creator":"jdanzl","relation":"main_file","file_id":"13601","file_name":"Extdata04_VGLUT_xy_1.tif","date_updated":"2023-08-03T12:16:08Z","checksum":"be17472f73ed8cd02a700b861f1dbac0","success":1,"file_size":11117763},{"content_type":"image/tiff","date_created":"2023-08-03T12:16:08Z","relation":"main_file","creator":"jdanzl","access_level":"open_access","checksum":"dbc3ec477f491ce3e98ab40475bd90ca","success":1,"date_updated":"2023-08-03T12:16:08Z","file_name":"Extdata04_VGLUT_xy_2-3.tif","file_id":"13602","file_size":72947},{"success":1,"checksum":"8ee877e6b843bb0e38febb0481962d69","date_updated":"2023-08-03T12:16:08Z","file_id":"13603","file_name":"Extdata04_VGLUT_xz_1-2.tif","file_size":53367,"date_created":"2023-08-03T12:16:08Z","content_type":"image/tiff","relation":"main_file","creator":"jdanzl","access_level":"open_access"},{"file_name":"Extdata04_VGLUT_xz_3-4.tif","file_id":"13604","date_updated":"2023-08-03T12:16:08Z","checksum":"9873f54d50955a2c204d0559c87aa13d","success":1,"file_size":53358,"content_type":"image/tiff","date_created":"2023-08-03T12:16:08Z","access_level":"open_access","creator":"jdanzl","relation":"main_file"},{"content_type":"image/tiff","date_created":"2023-08-03T12:16:11Z","access_level":"open_access","relation":"main_file","creator":"jdanzl","date_updated":"2023-08-03T12:16:11Z","file_name":"Extdata04_VGLUT_xz_n2v.tif","file_id":"13605","checksum":"8eda08ae5981fcfa3758d0320b1923af","success":1,"file_size":144076208},{"file_id":"13606","file_name":"Extdata04_VGLUT_xz.tif","date_updated":"2023-08-03T12:16:10Z","success":1,"checksum":"bc0b10229d498f60996a5b05cb87c428","file_size":72071440,"content_type":"image/tiff","date_created":"2023-08-03T12:16:10Z","access_level":"open_access","creator":"jdanzl","relation":"main_file"},{"access_level":"open_access","creator":"jdanzl","relation":"main_file","content_type":"image/tiff","date_created":"2023-08-03T12:32:32Z","file_size":7109763,"file_name":"Extdata03_VGAT_xy_1.tif","file_id":"13607","date_updated":"2023-08-03T12:32:32Z","success":1,"checksum":"e8d093ce7d98ea5647d8a80e3084c40b"},{"creator":"jdanzl","relation":"main_file","access_level":"open_access","date_created":"2023-08-03T12:32:32Z","content_type":"image/tiff","file_size":72947,"checksum":"36590ca7a586de7ad76d3ad659c38995","success":1,"file_id":"13608","file_name":"Extdata03_VGAT_xy_2-3.tif","date_updated":"2023-08-03T12:32:32Z"},{"file_size":53355,"date_updated":"2023-08-03T12:32:32Z","file_name":"Extdata03_VGAT_xz_1-2.tif","file_id":"13609","checksum":"3914c7709f69d4d18f23a9fb6dc64572","success":1,"access_level":"open_access","relation":"main_file","creator":"jdanzl","content_type":"image/tiff","date_created":"2023-08-03T12:32:32Z"},{"content_type":"image/tiff","date_created":"2023-08-03T12:32:32Z","relation":"main_file","creator":"jdanzl","access_level":"open_access","checksum":"fa98aa521adaefb9e4476fe519e88e59","success":1,"date_updated":"2023-08-03T12:32:32Z","file_id":"13610","file_name":"Extdata03_VGAT_xz_3-4.tif","file_size":53339},{"creator":"jdanzl","relation":"main_file","access_level":"open_access","date_created":"2023-08-03T12:32:36Z","content_type":"image/tiff","file_size":204861338,"success":1,"checksum":"cd6f384c51756977e37f45043c913252","file_id":"13611","file_name":"Extdata03_VGAT_xz_n2v.tif","date_updated":"2023-08-03T12:32:36Z"},{"checksum":"fb7e46feda5ac07877a91ad963da0e31","success":1,"date_updated":"2023-08-03T12:32:35Z","file_name":"Extdata03_VGAT_xz.tif","file_id":"13612","file_size":102457527,"content_type":"image/tiff","date_created":"2023-08-03T12:32:35Z","relation":"main_file","creator":"jdanzl","access_level":"open_access"},{"file_size":4348932,"file_id":"13613","file_name":"Extdata04_MUNC_xy_1.png","date_updated":"2023-08-03T12:36:46Z","success":1,"checksum":"fe033e0a377d391cd8e4af04987d9900","access_level":"open_access","creator":"jdanzl","relation":"main_file","date_created":"2023-08-03T12:36:46Z","content_type":"image/png"},{"access_level":"open_access","relation":"main_file","creator":"jdanzl","date_created":"2023-08-03T12:35:58Z","content_type":"image/tiff","file_size":72947,"date_updated":"2023-08-03T12:35:58Z","file_name":"Extdata04_MUNC_xy_2-3.tif","file_id":"13614","checksum":"771d8e2b9192b6620f54ab30e4fad594","success":1},{"date_created":"2023-08-03T12:35:58Z","content_type":"image/tiff","creator":"jdanzl","relation":"main_file","access_level":"open_access","success":1,"checksum":"4256d8f06fa2077b352776cf76b46618","file_id":"13615","file_name":"Extdata04_MUNC_xz_1-2.tif","date_updated":"2023-08-03T12:35:58Z","file_size":53435},{"date_created":"2023-08-03T12:35:58Z","content_type":"image/tiff","access_level":"open_access","creator":"jdanzl","relation":"main_file","file_id":"13616","file_name":"Extdata04_MUNC_xz_3-4.tif","date_updated":"2023-08-03T12:35:58Z","success":1,"checksum":"0b9365638c81d545e773170cf04b04b8","file_size":55941},{"date_created":"2023-08-03T12:36:04Z","content_type":"image/tiff","access_level":"open_access","relation":"main_file","creator":"jdanzl","date_updated":"2023-08-03T12:36:04Z","file_id":"13617","file_name":"Extdata04_MUNC_xz_n2v.tif","success":1,"checksum":"9fa62688dab03c592cec47bf5d1c304d","file_size":204861404},{"file_id":"13618","file_name":"Extdata04_MUNC_xz.tif","date_updated":"2023-08-03T12:36:02Z","checksum":"39f710080a26136dbbe4c8916b434c65","success":1,"file_size":102457527,"content_type":"image/tiff","date_created":"2023-08-03T12:36:02Z","access_level":"open_access","creator":"jdanzl","relation":"main_file"},{"date_updated":"2023-08-03T12:38:39Z","file_name":"Extdata04_BASSOON_xy_1.tif","file_id":"13619","success":1,"checksum":"eaabc8112645a73f4326e621b4e6ad0a","file_size":11117757,"date_created":"2023-08-03T12:38:39Z","content_type":"image/tiff","access_level":"open_access","relation":"main_file","creator":"jdanzl"},{"content_type":"image/tiff","date_created":"2023-08-03T12:38:39Z","access_level":"open_access","relation":"main_file","creator":"jdanzl","date_updated":"2023-08-03T12:38:39Z","file_name":"Extdata04_BASSOON_xy_2-3.tif","file_id":"13620","checksum":"15f624d29c473ce6e0ae7e466efc059a","success":1,"file_size":74041},{"file_size":53435,"date_updated":"2023-08-03T12:38:39Z","file_name":"Extdata04_BASSOON_xz_1-2.tif","file_id":"13621","success":1,"checksum":"1cb4b4d219767a30072c804a07140240","access_level":"open_access","relation":"main_file","creator":"jdanzl","date_created":"2023-08-03T12:38:39Z","content_type":"image/tiff"},{"content_type":"image/tiff","date_created":"2023-08-03T12:38:39Z","access_level":"open_access","creator":"jdanzl","relation":"main_file","file_id":"13622","file_name":"Extdata04_BASSOON_xz_3-4.tif","date_updated":"2023-08-03T12:38:39Z","success":1,"checksum":"1bac9c192da9375d81cb3747f48c9be4","file_size":53362},{"date_updated":"2023-08-03T12:38:50Z","file_name":"Extdata04_BASSOON_xz_n2v.tif","file_id":"13623","success":1,"checksum":"57fa91bfb1e2937e3449e57096b6fc74","file_size":576071410,"date_created":"2023-08-03T12:38:50Z","content_type":"image/tiff","access_level":"open_access","relation":"main_file","creator":"jdanzl"},{"content_type":"image/tiff","date_created":"2023-08-03T12:38:46Z","access_level":"open_access","creator":"jdanzl","relation":"main_file","file_name":"Extdata04_BASSOON_xz.tif","file_id":"13624","date_updated":"2023-08-03T12:38:46Z","success":1,"checksum":"ac51a734dcf7d1b94afcd4a471f10626","file_size":288066640},{"file_size":7109763,"file_id":"13625","file_name":"Extdata04_HOMER1_xy_1.tif","date_updated":"2023-08-03T12:40:57Z","checksum":"244043f7acba250d560e29123702dcd7","success":1,"access_level":"open_access","creator":"jdanzl","relation":"main_file","content_type":"image/tiff","date_created":"2023-08-03T12:40:57Z"},{"file_size":72963,"date_updated":"2023-08-03T12:40:57Z","file_name":"Extdata04_HOMER1_xy_2-3.tif","file_id":"13626","success":1,"checksum":"eff51ff97539f6491989bfc3d3f88860","access_level":"open_access","relation":"main_file","creator":"jdanzl","content_type":"image/tiff","date_created":"2023-08-03T12:40:57Z"},{"date_updated":"2023-08-03T12:40:57Z","file_name":"Extdata04_HOMER1_xz_1-2.tif","file_id":"13627","checksum":"df35046d9bca4e97a5625c5a55218cfb","success":1,"file_size":53375,"content_type":"image/tiff","date_created":"2023-08-03T12:40:57Z","access_level":"open_access","relation":"main_file","creator":"jdanzl"},{"checksum":"5dc7536f7aaea084dfc329537d8412ce","success":1,"date_updated":"2023-08-03T12:40:57Z","file_id":"13628","file_name":"Extdata04_HOMER1_xz_3-4.tif","file_size":53359,"date_created":"2023-08-03T12:40:57Z","content_type":"image/tiff","relation":"main_file","creator":"jdanzl","access_level":"open_access"},{"creator":"jdanzl","relation":"main_file","access_level":"open_access","content_type":"image/tiff","date_created":"2023-08-03T12:41:00Z","file_size":204861339,"checksum":"0b407669a26b9d7730a41361ceffda9a","success":1,"file_name":"Extdata04_HOMER1_xz_n2v.tif","file_id":"13629","date_updated":"2023-08-03T12:41:00Z"},{"file_size":102457527,"success":1,"checksum":"f95a0da9bea8b605fc2ed310190836b3","file_name":"Extdata04_HOMER1_xz.tif","file_id":"13630","date_updated":"2023-08-03T12:40:59Z","creator":"jdanzl","relation":"main_file","access_level":"open_access","content_type":"image/tiff","date_created":"2023-08-03T12:40:59Z"},{"content_type":"image/tiff","date_created":"2023-08-03T12:45:08Z","relation":"main_file","creator":"jdanzl","access_level":"open_access","checksum":"cf74307696548e7aa90e59a0935a74a1","success":1,"date_updated":"2023-08-03T12:45:08Z","file_name":"Extdata04_SHANK2_xy_1.tif","file_id":"13631","file_size":7120361},{"file_size":72973,"date_updated":"2023-08-03T12:45:08Z","file_id":"13632","file_name":"Extdata04_SHANK2_xy_2-3.tif","checksum":"7b3490246df4f5bb68d0df682161820f","success":1,"access_level":"open_access","relation":"main_file","creator":"jdanzl","date_created":"2023-08-03T12:45:08Z","content_type":"image/tiff"},{"checksum":"c599d6830e61c386219e266f4717fe7c","success":1,"date_updated":"2023-08-03T12:45:08Z","file_name":"Extdata04_SHANK2_xz_1-2.tif","file_id":"13633","file_size":53443,"content_type":"image/tiff","date_created":"2023-08-03T12:45:08Z","relation":"main_file","creator":"jdanzl","access_level":"open_access"},{"file_name":"Extdata04_SHANK2_xz_3-4.tif","file_id":"13634","date_updated":"2023-08-03T12:45:08Z","checksum":"5b9912b2a408d224ad669f39dc8d5bc6","success":1,"file_size":53362,"content_type":"image/tiff","date_created":"2023-08-03T12:45:08Z","access_level":"open_access","creator":"jdanzl","relation":"main_file"},{"file_size":691291157,"success":1,"checksum":"17f2064ceeb99cbb51208c27b1961ed5","date_updated":"2023-08-03T12:45:30Z","file_id":"13635","file_name":"Extdata04_SHANK2_xz_n2v.tif","relation":"main_file","creator":"jdanzl","access_level":"open_access","date_created":"2023-08-03T12:45:30Z","content_type":"image/tiff"},{"file_size":518519275,"file_name":"Extdata04_SHANK2_xz.tif","file_id":"13636","date_updated":"2023-08-03T12:45:26Z","checksum":"21f1bb8d2a00c88bdd6febe6285acc2a","success":1,"access_level":"open_access","creator":"jdanzl","relation":"main_file","content_type":"image/tiff","date_created":"2023-08-03T12:45:26Z"},{"date_created":"2023-08-03T12:46:25Z","content_type":"image/tiff","access_level":"open_access","relation":"main_file","creator":"jdanzl","date_updated":"2023-08-03T12:46:25Z","file_name":"Extdata04_GEPHYRIN_xy_1.tif","file_id":"13637","success":1,"checksum":"47597ca873f1ea81cd4f7e9bfbb34aa4","file_size":752109},{"file_size":72909,"date_updated":"2023-08-03T12:46:25Z","file_id":"13638","file_name":"Extdata04_GEPHYRIN_xy_2-3.tif","checksum":"14ed7ae64eb783e6b30f824f21959d0f","success":1,"access_level":"open_access","relation":"main_file","creator":"jdanzl","date_created":"2023-08-03T12:46:25Z","content_type":"image/tiff"},{"relation":"main_file","creator":"jdanzl","access_level":"open_access","date_created":"2023-08-03T12:46:25Z","content_type":"image/tiff","file_size":53375,"success":1,"checksum":"e361e226428d7b23618eed35b1cad080","date_updated":"2023-08-03T12:46:25Z","file_id":"13639","file_name":"Extdata04_GEPHYRIN_xz_1-2.tif"},{"date_created":"2023-08-03T12:46:25Z","content_type":"image/tiff","relation":"main_file","creator":"jdanzl","access_level":"open_access","success":1,"checksum":"abe7cee22f69fc2bf1a3ff9955ccf45a","date_updated":"2023-08-03T12:46:25Z","file_id":"13640","file_name":"Extdata04_GEPHYRIN_xz_3-4.tif","file_size":53360},{"date_created":"2023-08-03T12:46:27Z","content_type":"image/tiff","access_level":"open_access","creator":"jdanzl","relation":"main_file","file_name":"Extdata04_GEPHYRIN_xz_n2v.tif","file_id":"13641","date_updated":"2023-08-03T12:46:27Z","checksum":"59b49b451a63c5ac06fa31a17640c1a2","success":1,"file_size":73174939},{"date_created":"2023-08-03T12:46:26Z","content_type":"image/tiff","creator":"jdanzl","relation":"main_file","access_level":"open_access","success":1,"checksum":"1ee1feea85c8319ebc6c49147502e412","file_name":"Extdata04_GEPHYRIN_xz.tif","file_id":"13642","date_updated":"2023-08-03T12:46:26Z","file_size":36614327},{"relation":"main_file","creator":"jdanzl","access_level":"open_access","date_created":"2023-08-03T12:52:23Z","content_type":"image/tiff","file_size":2195652677,"checksum":"64d9d868ef89c5cfc65cb199aff831b4","success":1,"date_updated":"2023-08-03T12:52:23Z","file_id":"13643","file_name":"Extdata06_a-b_n2v.tif"},{"file_size":1097875840,"date_updated":"2023-08-03T12:51:41Z","file_name":"Extdata06_a-b.tif","file_id":"13644","checksum":"df41d97987798715b1f66e6e72be169b","success":1,"access_level":"open_access","relation":"main_file","creator":"jdanzl","content_type":"image/tiff","date_created":"2023-08-03T12:51:41Z"},{"content_type":"image/tiff","date_created":"2023-08-03T12:52:57Z","relation":"main_file","creator":"jdanzl","access_level":"open_access","success":1,"checksum":"95a3eaa3b70e964f6871a5765a53659b","date_updated":"2023-08-03T12:52:57Z","file_id":"13645","file_name":"Extdata07_01_bottom.tif","file_size":3564577},{"file_size":11958844,"checksum":"80b41ad0de73fd61eb67a35262627fac","success":1,"file_name":"Extdata07_01_top.tif","file_id":"13646","date_updated":"2023-08-03T12:52:57Z","creator":"jdanzl","relation":"main_file","access_level":"open_access","content_type":"image/tiff","date_created":"2023-08-03T12:52:57Z"},{"date_created":"2023-08-03T12:54:27Z","content_type":"image/tiff","creator":"jdanzl","relation":"main_file","access_level":"open_access","success":1,"checksum":"f694a0f11e2f782702cb4c411941873a","file_name":"Extdata07_2_bottom.tif","file_id":"13647","date_updated":"2023-08-03T12:54:27Z","file_size":3564581},{"file_size":11973592,"date_updated":"2023-08-03T12:54:27Z","file_id":"13648","file_name":"Extdata07_2_top.tif","checksum":"b8b1a1339a25806615c0aa7906a032ff","success":1,"access_level":"open_access","relation":"main_file","creator":"jdanzl","date_created":"2023-08-03T12:54:27Z","content_type":"image/tiff"},{"creator":"jdanzl","relation":"main_file","access_level":"open_access","date_created":"2023-08-03T12:54:27Z","content_type":"image/tiff","file_size":1281901,"checksum":"8a24eb623d65d809fe8afbd527528a77","success":1,"file_id":"13649","file_name":"Extdata07_3_bottom.tif","date_updated":"2023-08-03T12:54:27Z"},{"file_name":"Extdata07_3_top.tif","file_id":"13650","date_updated":"2023-08-03T12:54:27Z","success":1,"checksum":"816b35def703bc48d55b0293fcd8212f","file_size":16569776,"date_created":"2023-08-03T12:54:27Z","content_type":"image/tiff","access_level":"open_access","creator":"jdanzl","relation":"main_file"},{"creator":"jdanzl","relation":"main_file","access_level":"open_access","date_created":"2023-08-03T12:54:27Z","content_type":"image/tiff","file_size":3564595,"success":1,"checksum":"7f1375ab8cf28cd136e2e44d1fdfd87d","file_id":"13651","file_name":"Extdata07_04_bottom.tif","date_updated":"2023-08-03T12:54:27Z"},{"file_size":5896404,"checksum":"b1dbda28e2a010968716c0411568f139","success":1,"file_id":"13652","file_name":"Extdata07_04_top.tif","date_updated":"2023-08-03T12:54:27Z","creator":"jdanzl","relation":"main_file","access_level":"open_access","date_created":"2023-08-03T12:54:27Z","content_type":"image/tiff"},{"file_size":3564609,"date_updated":"2023-08-03T12:54:28Z","file_name":"Extdata07_5_bottom.tif","file_id":"13653","checksum":"d6e96b7c8e6a7084c14eda83a4dd778a","success":1,"access_level":"open_access","relation":"main_file","creator":"jdanzl","content_type":"image/tiff","date_created":"2023-08-03T12:54:28Z"},{"date_updated":"2023-08-03T12:54:28Z","file_name":"Extdata07_5_top.tif","file_id":"13654","success":1,"checksum":"a647f89a3048f71512cc58c9e53ec022","file_size":15555618,"content_type":"image/tiff","date_created":"2023-08-03T12:54:28Z","access_level":"open_access","relation":"main_file","creator":"jdanzl"},{"date_created":"2023-08-03T12:54:28Z","content_type":"image/tiff","access_level":"open_access","relation":"main_file","creator":"jdanzl","date_updated":"2023-08-03T12:54:28Z","file_id":"13655","file_name":"Extdata07_6_bottom.tif","checksum":"66becb046fe591914df572617d720202","success":1,"file_size":3564577},{"date_created":"2023-08-03T12:54:28Z","content_type":"image/tiff","access_level":"open_access","creator":"jdanzl","relation":"main_file","file_name":"Extdata07_6_top.tif","file_id":"13656","date_updated":"2023-08-03T12:54:28Z","checksum":"5d76b2ad7d7acbb1afa27cf52194b1cb","success":1,"file_size":6038186},{"file_size":3560937,"file_id":"13657","file_name":"Extdata07_7_bottom.tif","date_updated":"2023-08-03T12:54:28Z","checksum":"7f137bdea0f0acb3db75c983ce44ab44","success":1,"access_level":"open_access","creator":"jdanzl","relation":"main_file","date_created":"2023-08-03T12:54:28Z","content_type":"image/tiff"},{"content_type":"image/tiff","date_created":"2023-08-03T12:54:28Z","relation":"main_file","creator":"jdanzl","access_level":"open_access","checksum":"479e26106280eb61a2d74e29137a2e43","success":1,"date_updated":"2023-08-03T12:54:28Z","file_name":"Extdata07_7_top.tif","file_id":"13658","file_size":12031850},{"creator":"jdanzl","relation":"main_file","access_level":"open_access","content_type":"image/tiff","date_created":"2023-08-03T12:54:28Z","file_size":3560937,"success":1,"checksum":"8426197ad283c1bc83e3193f323d5f5a","file_id":"13659","file_name":"Extdata07_8_bottom.tif","date_updated":"2023-08-03T12:54:28Z"},{"creator":"jdanzl","relation":"main_file","access_level":"open_access","content_type":"image/tiff","date_created":"2023-08-03T12:54:28Z","file_size":22877176,"checksum":"b9f75a82b564e1c5c363a495d078f6b7","success":1,"file_name":"Extdata07_8_top.tif","file_id":"13660","date_updated":"2023-08-03T12:54:28Z"},{"content_type":"image/tiff","date_created":"2023-08-03T12:54:28Z","relation":"main_file","creator":"jdanzl","access_level":"open_access","success":1,"checksum":"7f1a9f3bb9611362995ae832b2607f4d","date_updated":"2023-08-03T12:54:28Z","file_id":"13661","file_name":"Extdata07_9_bottom.tif","file_size":3564605},{"checksum":"40286bcb876b655d7421534d0215e86b","success":1,"file_id":"13662","file_name":"Extdata07_9_top.tif","date_updated":"2023-08-03T12:54:28Z","file_size":2744190,"content_type":"image/tiff","date_created":"2023-08-03T12:54:28Z","creator":"jdanzl","relation":"main_file","access_level":"open_access"},{"file_size":7243611,"file_id":"13663","file_name":"Extdata08_6_left.png","date_updated":"2023-08-03T13:00:03Z","checksum":"4af220986cc94d412c2354aa7e6c8cce","success":1,"access_level":"open_access","creator":"jdanzl","relation":"main_file","content_type":"image/png","date_created":"2023-08-03T13:00:03Z"},{"file_size":5562487,"date_updated":"2023-08-03T13:00:03Z","file_name":"Extdata08_6_right.tif","file_id":"13664","success":1,"checksum":"af9c2299f1005a3ccc39f41082cea642","access_level":"open_access","relation":"main_file","creator":"jdanzl","content_type":"image/tiff","date_created":"2023-08-03T13:00:03Z"},{"relation":"main_file","creator":"jdanzl","access_level":"open_access","content_type":"image/tiff","date_created":"2023-08-03T13:00:04Z","file_size":34745956,"success":1,"checksum":"63ef28a174215c70e31d2cabf67d90fc","date_updated":"2023-08-03T13:00:04Z","file_id":"13665","file_name":"Extdata08_7_left.tif"},{"creator":"jdanzl","relation":"main_file","access_level":"open_access","content_type":"image/tiff","date_created":"2023-08-03T13:00:03Z","file_size":5562483,"checksum":"46de918dfe5f3c23e497ee3daa608dd9","success":1,"file_id":"13666","file_name":"Extdata08_7_right.tif","date_updated":"2023-08-03T13:00:03Z"},{"relation":"main_file","creator":"jdanzl","access_level":"open_access","content_type":"image/tiff","date_created":"2023-08-03T13:00:04Z","file_size":31506150,"checksum":"8243a7985d2902446183adc35519a0c8","success":1,"date_updated":"2023-08-03T13:00:04Z","file_id":"13667","file_name":"Extdata08_b_1_left.tif"},{"file_size":11117705,"checksum":"857cffa31569efcd5917f9802a106d58","success":1,"date_updated":"2023-08-03T13:00:04Z","file_id":"13668","file_name":"Extdata08_b_1_right.tif","relation":"main_file","creator":"jdanzl","access_level":"open_access","date_created":"2023-08-03T13:00:04Z","content_type":"image/tiff"},{"creator":"jdanzl","relation":"main_file","access_level":"open_access","date_created":"2023-08-03T13:00:04Z","content_type":"image/png","file_size":3540493,"checksum":"e34902de9119d2cd9f1910f610627c5f","success":1,"file_name":"Extdata08_b_2_left.png","file_id":"13669","date_updated":"2023-08-03T13:00:04Z"},{"file_size":5562553,"date_updated":"2023-08-03T13:00:05Z","file_id":"13670","file_name":"Extdata08_b_2_right.tif","success":1,"checksum":"1247d636ac5af22e8950ffd2ff213fea","access_level":"open_access","relation":"main_file","creator":"jdanzl","date_created":"2023-08-03T13:00:05Z","content_type":"image/tiff"},{"file_size":3541547,"date_updated":"2023-08-03T13:00:05Z","file_name":"Extdata08_b_3_left.png","file_id":"13671","success":1,"checksum":"f47c2d3f6824e08853ae2631f6ee7c5f","access_level":"open_access","relation":"main_file","creator":"jdanzl","content_type":"image/png","date_created":"2023-08-03T13:00:05Z"},{"relation":"main_file","creator":"jdanzl","access_level":"open_access","content_type":"image/tiff","date_created":"2023-08-03T13:00:05Z","file_size":5562553,"success":1,"checksum":"1247d636ac5af22e8950ffd2ff213fea","date_updated":"2023-08-03T13:00:05Z","file_name":"Extdata08_b_3_right.tif","file_id":"13672"},{"date_updated":"2023-08-03T13:00:05Z","file_id":"13673","file_name":"Extdata08_b_4_left.tif","checksum":"e90a95ec902a683678acd70336852fd9","success":1,"file_size":25819844,"date_created":"2023-08-03T13:00:05Z","content_type":"image/tiff","access_level":"open_access","relation":"main_file","creator":"jdanzl"},{"access_level":"open_access","relation":"main_file","creator":"jdanzl","content_type":"image/tiff","date_created":"2023-08-03T13:00:05Z","file_size":5561131,"date_updated":"2023-08-03T13:00:05Z","file_name":"Extdata08_b_4_right.tif","file_id":"13674","checksum":"94cd44cd1c8c7a87ffd5861bf88561a1","success":1},{"date_created":"2023-08-03T13:00:06Z","content_type":"image/tiff","access_level":"open_access","relation":"main_file","creator":"jdanzl","date_updated":"2023-08-03T13:00:06Z","file_id":"13675","file_name":"Extdata08_b_5_left.tif","checksum":"fd4ca56dc5c48ad4546df22daef04efc","success":1,"file_size":38786287},{"access_level":"open_access","relation":"main_file","creator":"jdanzl","content_type":"image/tiff","date_created":"2023-08-03T13:00:06Z","file_size":5562487,"date_updated":"2023-08-03T13:00:06Z","file_id":"13676","file_name":"Extdata08_b_5_right.tif","success":1,"checksum":"52c04890160c4e0f23d3fe2d3ed0c8e7"},{"file_size":2133527,"success":1,"checksum":"47ee6f4b083130d5bb720bcf8a832443","date_updated":"2023-08-03T13:04:52Z","file_id":"13677","file_name":"Extdata08_a_1-1.png","relation":"main_file","creator":"jdanzl","access_level":"open_access","content_type":"image/png","date_created":"2023-08-03T13:04:52Z"},{"creator":"jdanzl","relation":"main_file","access_level":"open_access","date_created":"2023-08-03T13:04:52Z","content_type":"image/png","file_size":1782607,"checksum":"5ca2279c372b3b7dbce3ea5658a68399","success":1,"file_name":"Extdata08_a_1-2.png","file_id":"13678","date_updated":"2023-08-03T13:04:52Z"},{"date_updated":"2023-08-03T13:04:52Z","file_id":"13679","file_name":"Extdata08_a_2.png","checksum":"34b7781e3e4abf9f30a0c85db156b6d5","success":1,"file_size":5117469,"content_type":"image/png","date_created":"2023-08-03T13:04:52Z","access_level":"open_access","relation":"main_file","creator":"jdanzl"},{"creator":"jdanzl","relation":"main_file","access_level":"open_access","date_created":"2023-08-03T13:04:52Z","content_type":"image/png","file_size":6911658,"success":1,"checksum":"25717007393682098d2208bd0676a0f7","file_name":"Extdata08_a_3.png","file_id":"13680","date_updated":"2023-08-03T13:04:52Z"},{"creator":"jdanzl","relation":"main_file","access_level":"open_access","date_created":"2023-08-03T13:04:53Z","content_type":"image/png","file_size":8579427,"checksum":"b4b003809acec33c71628066744c7ea9","success":1,"file_id":"13681","file_name":"Extdata08_a_4.png","date_updated":"2023-08-03T13:04:53Z"},{"file_size":9675065,"checksum":"4410976cf867ecacf8f197dbd28cc5a0","success":1,"date_updated":"2023-08-03T13:04:53Z","file_id":"13682","file_name":"Extdata08_a_5.png","relation":"main_file","creator":"jdanzl","access_level":"open_access","content_type":"image/png","date_created":"2023-08-03T13:04:53Z"},{"access_level":"open_access","creator":"jdanzl","relation":"main_file","content_type":"image/png","date_created":"2023-08-03T13:04:53Z","file_size":9769588,"file_id":"13683","file_name":"Extdata08_a_6.png","date_updated":"2023-08-03T13:04:53Z","success":1,"checksum":"a235dd204f28d3323883e044b031b984"},{"file_size":9114791,"success":1,"checksum":"0e2b768e4eb7200cf6fe28ba511a5ef6","file_id":"13684","file_name":"Extdata08_a_7.png","date_updated":"2023-08-03T13:04:53Z","creator":"jdanzl","relation":"main_file","access_level":"open_access","content_type":"image/png","date_created":"2023-08-03T13:04:53Z"},{"access_level":"open_access","creator":"jdanzl","relation":"main_file","content_type":"image/png","date_created":"2023-08-03T13:04:57Z","file_size":124540688,"file_name":"Extdata08_a_8.png","file_id":"13685","date_updated":"2023-08-03T13:04:57Z","success":1,"checksum":"df4a01c62233ee8ed601c4b90d7780d0"},{"content_type":"image/tiff","date_created":"2023-08-03T13:11:30Z","access_level":"open_access","relation":"main_file","creator":"jdanzl","date_updated":"2023-08-03T13:11:30Z","file_name":"Exdata09_c_n2v.tif","file_id":"13686","success":1,"checksum":"1f407c7915e2717a56fec258708e7b7a","file_size":204861336},{"date_created":"2023-08-03T13:11:26Z","content_type":"image/tiff","access_level":"open_access","creator":"jdanzl","relation":"main_file","file_name":"Extdata09_a_zoom.tif","file_id":"13687","date_updated":"2023-08-03T13:11:26Z","checksum":"9089dc7c9914edf9750eebd65819708d","success":1,"file_size":252149},{"content_type":"image/tiff","date_created":"2023-08-03T13:11:26Z","relation":"main_file","creator":"jdanzl","access_level":"open_access","checksum":"62d295a62cb8dd36c268b28cf0251322","success":1,"date_updated":"2023-08-03T13:11:26Z","file_id":"13688","file_name":"Extdata09_a.tif","file_size":11117705},{"relation":"main_file","creator":"jdanzl","access_level":"open_access","content_type":"image/tiff","date_created":"2023-08-03T13:11:31Z","file_size":256074660,"success":1,"checksum":"e874d8ee287f924c1076134b5b06bdb2","date_updated":"2023-08-03T13:11:31Z","file_name":"Extdata09_b_n2v.tif","file_id":"13689"},{"file_name":"Extdata10_n2v_CLAHE.tif","file_id":"13690","date_updated":"2023-08-03T13:12:53Z","success":1,"checksum":"488068fff7b42bcf5728739e2a06d742","file_size":127914854,"content_type":"image/tiff","date_created":"2023-08-03T13:12:53Z","access_level":"open_access","creator":"jdanzl","relation":"main_file"},{"creator":"jdanzl","relation":"main_file","access_level":"open_access","content_type":"image/png","date_created":"2023-08-03T13:21:35Z","file_size":430878,"success":1,"checksum":"35351f5af21ce854d41577813a7bdb57","file_name":"Supplfig01_a_1.png","file_id":"13691","date_updated":"2023-08-03T13:21:35Z"},{"date_updated":"2023-08-03T13:21:35Z","file_id":"13692","file_name":"Supplfig01_a_2.png","checksum":"36204e9e604206366ffc6f61ec91915b","success":1,"file_size":438843,"content_type":"image/png","date_created":"2023-08-03T13:21:35Z","access_level":"open_access","relation":"main_file","creator":"jdanzl"},{"date_updated":"2023-08-03T13:21:35Z","file_id":"13693","file_name":"Supplfig01_a_3.png","success":1,"checksum":"92ccc934c4603b29f4f7a96573e49c83","file_size":426713,"date_created":"2023-08-03T13:21:35Z","content_type":"image/png","access_level":"open_access","relation":"main_file","creator":"jdanzl"},{"access_level":"open_access","creator":"jdanzl","relation":"main_file","date_created":"2023-08-03T13:21:35Z","content_type":"image/tiff","file_size":723221,"file_id":"13694","file_name":"Supplfig01_a_4.tif","date_updated":"2023-08-03T13:21:35Z","success":1,"checksum":"e71faa54934bee8ac3e66ce692f542ab"},{"date_updated":"2023-08-03T13:21:35Z","file_name":"Supplfig01_a_5.tif","file_id":"13695","success":1,"checksum":"95dc33563f48b650e5ac020bdfd10c48","file_size":723235,"content_type":"image/tiff","date_created":"2023-08-03T13:21:35Z","access_level":"open_access","relation":"main_file","creator":"jdanzl"},{"content_type":"image/tiff","date_created":"2023-08-03T13:21:35Z","relation":"main_file","creator":"jdanzl","access_level":"open_access","success":1,"checksum":"c62df0a9faf1c47af121d77eb1582edd","date_updated":"2023-08-03T13:21:35Z","file_id":"13696","file_name":"Supplfig01_b_1.tif","file_size":1442129},{"date_updated":"2023-08-03T13:21:35Z","file_id":"13697","file_name":"Supplfig01_b_2.tif","checksum":"8ae157c5a4a543da1193cb8ca12b1919","success":1,"file_size":725407,"content_type":"image/tiff","date_created":"2023-08-03T13:21:35Z","access_level":"open_access","relation":"main_file","creator":"jdanzl"},{"file_name":"Supplfig01_c_1.tif","file_id":"13698","date_updated":"2023-08-03T13:21:35Z","checksum":"388370d954ce842781c0d62edfb448a7","success":1,"file_size":721641,"content_type":"image/tiff","date_created":"2023-08-03T13:21:35Z","access_level":"open_access","creator":"jdanzl","relation":"main_file"},{"access_level":"open_access","creator":"jdanzl","relation":"main_file","content_type":"image/tiff","date_created":"2023-08-03T13:21:35Z","file_size":6003079,"file_name":"Supplfig01_c_2.tif","file_id":"13699","date_updated":"2023-08-03T13:21:35Z","checksum":"6cae58ba3c98bc8253e1c769e93657a7","success":1},{"file_name":"Supplfig01_c_3.tif","file_id":"13700","date_updated":"2023-08-03T13:21:35Z","success":1,"checksum":"85cf013232c72895aefc07f5411a765a","file_size":2003311,"date_created":"2023-08-03T13:21:35Z","content_type":"image/tiff","access_level":"open_access","creator":"jdanzl","relation":"main_file"},{"access_level":"open_access","relation":"main_file","creator":"jdanzl","content_type":"image/tiff","date_created":"2023-08-03T13:21:35Z","file_size":723271,"date_updated":"2023-08-03T13:21:35Z","file_name":"Supplfig01_c_4.tif","file_id":"13701","checksum":"dfb33b91066e3f34d3803f59a4105aba","success":1},{"file_size":721901,"date_updated":"2023-08-03T13:21:35Z","file_id":"13702","file_name":"Supplfig01_d_1.tif","checksum":"8b899826fe48d7e7536b0b02a2645e87","success":1,"access_level":"open_access","relation":"main_file","creator":"jdanzl","date_created":"2023-08-03T13:21:35Z","content_type":"image/tiff"},{"date_created":"2023-08-03T13:21:35Z","content_type":"image/tiff","access_level":"open_access","creator":"jdanzl","relation":"main_file","file_name":"Supplfig01_d_2.tif","file_id":"13703","date_updated":"2023-08-03T13:21:35Z","checksum":"67529fa6e0f12c272275e823f6045f6d","success":1,"file_size":721901},{"creator":"jdanzl","relation":"main_file","access_level":"open_access","content_type":"image/tiff","date_created":"2023-08-03T13:21:35Z","file_size":723223,"success":1,"checksum":"111a9231f63c775340d3356109715cb0","file_id":"13704","file_name":"Supplfig01_e_1.tif","date_updated":"2023-08-03T13:21:35Z"},{"success":1,"checksum":"7685bf02408dcb095a00854ff22763ed","file_id":"13705","file_name":"Supplfig01_e_2.tif","date_updated":"2023-08-03T13:21:35Z","file_size":723223,"content_type":"image/tiff","date_created":"2023-08-03T13:21:35Z","creator":"jdanzl","relation":"main_file","access_level":"open_access"},{"file_size":34821298,"file_name":"Supplfig02_b_01.tif","file_id":"13706","date_updated":"2023-08-03T13:26:00Z","success":1,"checksum":"455f5cb9aa8a87b91586a27aca122610","access_level":"open_access","creator":"jdanzl","relation":"main_file","content_type":"image/tiff","date_created":"2023-08-03T13:26:00Z"},{"creator":"jdanzl","relation":"main_file","access_level":"open_access","content_type":"image/tiff","date_created":"2023-08-03T13:26:00Z","file_size":32131123,"success":1,"checksum":"311545b39aaa2c72755fd8ae190803a5","file_name":"Supplfig02_b_02.tif","file_id":"13707","date_updated":"2023-08-03T13:26:00Z"},{"content_type":"image/tiff","date_created":"2023-08-03T13:26:01Z","creator":"jdanzl","relation":"main_file","access_level":"open_access","checksum":"682deb61f57d9ca54716160ddd52a6cf","success":1,"file_id":"13708","file_name":"Supplfig02_b_03.tif","date_updated":"2023-08-03T13:26:01Z","file_size":36872674},{"date_updated":"2023-08-03T13:26:01Z","file_id":"13709","file_name":"Supplfig02_b_04.tif","checksum":"4f9579c91b2a3f36ff6e66b592907973","success":1,"file_size":39964115,"date_created":"2023-08-03T13:26:01Z","content_type":"image/tiff","access_level":"open_access","relation":"main_file","creator":"jdanzl"},{"checksum":"7ae7053673b53dbed59ffb92618f969a","success":1,"file_name":"Supplfig02_b_05.tif","file_id":"13710","date_updated":"2023-08-03T13:26:02Z","file_size":43053091,"date_created":"2023-08-03T13:26:02Z","content_type":"image/tiff","creator":"jdanzl","relation":"main_file","access_level":"open_access"},{"success":1,"checksum":"827b26d3d2b6ddc9bced9d6113023ced","file_id":"13711","file_name":"Supplfig02_b_06.tif","date_updated":"2023-08-03T13:26:02Z","file_size":46998147,"date_created":"2023-08-03T13:26:02Z","content_type":"image/tiff","creator":"jdanzl","relation":"main_file","access_level":"open_access"},{"access_level":"open_access","relation":"main_file","creator":"jdanzl","content_type":"image/tiff","date_created":"2023-08-03T13:26:03Z","file_size":45179219,"date_updated":"2023-08-03T13:26:03Z","file_id":"13712","file_name":"Supplfig02_b_07.tif","checksum":"bc2e7e8badb42f8e1facc8b7bc96fdda","success":1},{"access_level":"open_access","creator":"jdanzl","relation":"main_file","date_created":"2023-08-03T13:26:03Z","content_type":"image/tiff","file_size":46978802,"file_name":"Supplfig02_b_08.tif","file_id":"13713","date_updated":"2023-08-03T13:26:03Z","success":1,"checksum":"c2b78aa0f433928afa10a743c5fb73b8"},{"file_size":48840915,"success":1,"checksum":"9cd1ab61cced2c0981e813aeae930855","file_id":"13714","file_name":"Supplfig02_b_09.tif","date_updated":"2023-08-03T13:26:04Z","creator":"jdanzl","relation":"main_file","access_level":"open_access","date_created":"2023-08-03T13:26:04Z","content_type":"image/tiff"},{"file_size":45907059,"date_updated":"2023-08-03T13:26:04Z","file_id":"13715","file_name":"Supplfig02_b_10.tif","checksum":"3086126338aee6ec4ebc1d3350551197","success":1,"access_level":"open_access","relation":"main_file","creator":"jdanzl","date_created":"2023-08-03T13:26:04Z","content_type":"image/tiff"},{"access_level":"open_access","creator":"jdanzl","relation":"main_file","date_created":"2023-08-03T13:26:05Z","content_type":"image/tiff","file_size":32231538,"file_id":"13716","file_name":"Supplfig02_b_11.tif","date_updated":"2023-08-03T13:26:05Z","checksum":"69f52c2b3bb5b5f9fef057860b3386fa","success":1},{"file_size":35264963,"success":1,"checksum":"defdbeab1e672456bfeafdd1983e779e","file_id":"13717","file_name":"Supplfig02_b_12.tif","date_updated":"2023-08-03T13:26:05Z","creator":"jdanzl","relation":"main_file","access_level":"open_access","content_type":"image/tiff","date_created":"2023-08-03T13:26:05Z"},{"relation":"main_file","creator":"jdanzl","access_level":"open_access","content_type":"image/png","date_created":"2023-08-03T13:28:40Z","file_size":63326,"success":1,"checksum":"02c566f781b9ad44f04ce0088a1fa27a","date_updated":"2023-08-03T13:28:40Z","file_id":"13718","file_name":"Supplfig03_a_std_xy.png"},{"file_size":50211,"date_updated":"2023-08-03T13:28:40Z","file_id":"13719","file_name":"Supplfig03_a_std_xz.png","checksum":"c6c3630ee9a6ed5d207cb68e330da566","success":1,"access_level":"open_access","relation":"main_file","creator":"jdanzl","content_type":"image/png","date_created":"2023-08-03T13:28:40Z"},{"access_level":"open_access","creator":"jdanzl","relation":"main_file","date_created":"2023-08-03T13:28:41Z","content_type":"image/png","file_size":52629,"file_name":"Supplfig03_b_std_xy.png","file_id":"13720","date_updated":"2023-08-03T13:28:41Z","checksum":"0dcd4d19e83a7ff259d6aa04d746cd90","success":1},{"date_created":"2023-08-03T13:28:41Z","content_type":"image/png","creator":"jdanzl","relation":"main_file","access_level":"open_access","success":1,"checksum":"4785de4a6dcb23b25a06b0da29df5bb5","file_name":"Supplfig03_b_std_xz.png","file_id":"13721","date_updated":"2023-08-03T13:28:41Z","file_size":72245},{"file_name":"Supplfig03_model1.tif","file_id":"13722","date_updated":"2023-08-03T13:28:45Z","checksum":"19d0f198bd8a25073e45e7950d7a78c2","success":1,"file_size":98570368,"content_type":"image/tiff","date_created":"2023-08-03T13:28:45Z","access_level":"open_access","creator":"jdanzl","relation":"main_file"},{"file_size":98570367,"date_updated":"2023-08-03T13:28:45Z","file_id":"13723","file_name":"Supplfig03_model2.tif","checksum":"51ff687df4a0867f39b69c2c7a4ee3ca","success":1,"access_level":"open_access","relation":"main_file","creator":"jdanzl","content_type":"image/tiff","date_created":"2023-08-03T13:28:45Z"},{"success":1,"checksum":"ec9d9a041ca85fe632c612baf981fcc5","file_id":"13724","file_name":"Supplfig03_model3.tif","date_updated":"2023-08-03T13:28:49Z","file_size":98570365,"date_created":"2023-08-03T13:28:49Z","content_type":"image/tiff","creator":"jdanzl","relation":"main_file","access_level":"open_access"},{"file_size":98570365,"date_updated":"2023-08-03T13:28:49Z","file_name":"Supplfig03_model4.tif","file_id":"13725","success":1,"checksum":"a988b15a9529094f1b5519a72871e98e","access_level":"open_access","relation":"main_file","creator":"jdanzl","date_created":"2023-08-03T13:28:49Z","content_type":"image/tiff"},{"file_size":98570369,"checksum":"4a4fe88fcfd87fcfe118a5a73d81d6b0","success":1,"file_name":"Supplfig03_model5.tif","file_id":"13726","date_updated":"2023-08-03T13:28:52Z","creator":"jdanzl","relation":"main_file","access_level":"open_access","date_created":"2023-08-03T13:28:52Z","content_type":"image/tiff"},{"file_size":1036927887,"success":1,"checksum":"ce9b774ff5163ebfa4e3fb162f4cfffe","file_id":"13727","file_name":"Supplfig04_a_n2v.tif","date_updated":"2023-08-03T13:34:27Z","creator":"jdanzl","relation":"main_file","access_level":"open_access","date_created":"2023-08-03T13:34:27Z","content_type":"image/tiff"},{"file_size":518519275,"date_updated":"2023-08-03T13:34:13Z","file_id":"13728","file_name":"Supplfig04_a.tif","success":1,"checksum":"21f1bb8d2a00c88bdd6febe6285acc2a","access_level":"open_access","relation":"main_file","creator":"jdanzl","date_created":"2023-08-03T13:34:13Z","content_type":"image/tiff"},{"content_type":"image/tiff","date_created":"2023-08-03T13:34:22Z","creator":"jdanzl","relation":"main_file","access_level":"open_access","checksum":"503820214ab994c01b18a241f3b62434","success":1,"file_id":"13729","file_name":"Supplfig04_b.tif","date_updated":"2023-08-03T13:34:22Z","file_size":158440069},{"content_type":"image/tiff","date_created":"2023-08-03T13:34:37Z","access_level":"open_access","relation":"main_file","creator":"jdanzl","date_updated":"2023-08-03T13:34:37Z","file_id":"13730","file_name":"Supplfig04_c_n2v.tif","success":1,"checksum":"e0469102a87332b46904b4ba35b8fb2f","file_size":309407894},{"file_id":"13731","file_name":"Supplfig04_c.tif","date_updated":"2023-08-03T13:34:38Z","checksum":"c30a0d18c43045a8fbc5501a37061bd2","success":1,"file_size":154728887,"content_type":"image/tiff","date_created":"2023-08-03T13:34:38Z","access_level":"open_access","creator":"jdanzl","relation":"main_file"},{"access_level":"open_access","creator":"jdanzl","relation":"main_file","date_created":"2023-08-03T13:34:43Z","content_type":"image/tiff","file_size":106696749,"file_name":"Supplfig04_d_n2v.tif","file_id":"13732","date_updated":"2023-08-03T13:34:43Z","checksum":"69c706710d642b30cda6951494702139","success":1},{"checksum":"7dbd2e881ebf049352913188fa10224a","success":1,"date_updated":"2023-08-03T13:34:41Z","file_name":"Supplfig04_d.tif","file_id":"13733","file_size":53367343,"content_type":"image/tiff","date_created":"2023-08-03T13:34:41Z","relation":"main_file","creator":"jdanzl","access_level":"open_access"},{"date_created":"2023-08-03T13:34:46Z","content_type":"image/tiff","access_level":"open_access","creator":"jdanzl","relation":"main_file","file_name":"Supplfig04_e_n2v.tiff","file_id":"13734","date_updated":"2023-08-03T13:34:46Z","success":1,"checksum":"fd0d1ec674dabbb499fab383b7eb4d58","file_size":127917734},{"access_level":"open_access","creator":"jdanzl","relation":"main_file","date_created":"2023-08-03T13:34:46Z","content_type":"image/tiff","file_size":63974204,"file_id":"13735","file_name":"Supplfig04_e.tif","date_updated":"2023-08-03T13:34:46Z","checksum":"86de309d9cd434afbe371da283d8adb6","success":1},{"date_updated":"2023-08-03T13:35:37Z","file_name":"Supplfig05_a_xy_1.png","file_id":"13736","success":1,"checksum":"ada99b2b5900cb198d1de3cc9e37ebd1","file_size":8403,"date_created":"2023-08-03T13:35:37Z","content_type":"image/png","access_level":"open_access","relation":"main_file","creator":"jdanzl"},{"file_size":10087,"success":1,"checksum":"f2e382925a972b98560614016ae3bc55","file_id":"13737","file_name":"Supplfig05_a_xy_2.png","date_updated":"2023-08-03T13:35:37Z","creator":"jdanzl","relation":"main_file","access_level":"open_access","content_type":"image/png","date_created":"2023-08-03T13:35:37Z"},{"file_size":24561,"checksum":"ef22b640f33d677add1a7b5153f95420","success":1,"file_id":"13738","file_name":"Supplfig05_a_xy_3.png","date_updated":"2023-08-03T13:35:37Z","creator":"jdanzl","relation":"main_file","access_level":"open_access","date_created":"2023-08-03T13:35:37Z","content_type":"image/png"},{"access_level":"open_access","relation":"main_file","creator":"jdanzl","date_created":"2023-08-03T13:35:37Z","content_type":"image/png","file_size":8353,"date_updated":"2023-08-03T13:35:37Z","file_name":"Supplfig05_a_xy_4.png","file_id":"13739","success":1,"checksum":"b854cc4a5224b8a6f5d59c74f5740ccd"},{"success":1,"checksum":"446b0362c5ea6e2a5f0e1f8359422358","date_updated":"2023-08-03T13:35:37Z","file_id":"13740","file_name":"Supplfig05_a_xy_5.png","file_size":8337,"content_type":"image/png","date_created":"2023-08-03T13:35:37Z","relation":"main_file","creator":"jdanzl","access_level":"open_access"},{"checksum":"5585f7b62fa09ed5a63090b679383601","success":1,"file_name":"Supplfig05_a_xz_1.png","file_id":"13741","date_updated":"2023-08-03T13:35:37Z","file_size":7399,"content_type":"image/png","date_created":"2023-08-03T13:35:37Z","creator":"jdanzl","relation":"main_file","access_level":"open_access"},{"date_created":"2023-08-03T13:35:37Z","content_type":"image/png","access_level":"open_access","creator":"jdanzl","relation":"main_file","file_id":"13742","file_name":"Supplfig05_a_xz_2.png","date_updated":"2023-08-03T13:35:37Z","success":1,"checksum":"190d88bcacbd11d41f4a0e2bbd140862","file_size":10887},{"success":1,"checksum":"0c89010651862f21032a303e159b7a1c","file_id":"13743","file_name":"Supplfig05_a_xz_3.png","date_updated":"2023-08-03T13:35:37Z","file_size":21654,"content_type":"image/png","date_created":"2023-08-03T13:35:37Z","creator":"jdanzl","relation":"main_file","access_level":"open_access"},{"success":1,"checksum":"94e61e553aa2280721acce7d407ff24a","date_updated":"2023-08-03T13:35:37Z","file_id":"13744","file_name":"Supplfig05_a_xz_4.png","file_size":7248,"date_created":"2023-08-03T13:35:37Z","content_type":"image/png","relation":"main_file","creator":"jdanzl","access_level":"open_access"},{"access_level":"open_access","creator":"jdanzl","relation":"main_file","content_type":"image/png","date_created":"2023-08-03T13:35:37Z","file_size":7214,"file_id":"13745","file_name":"Supplfig05_a_xz_5.png","date_updated":"2023-08-03T13:35:37Z","success":1,"checksum":"ef9157274686ff5d7056f5a519d413dd"},{"relation":"main_file","creator":"jdanzl","access_level":"open_access","content_type":"image/png","date_created":"2023-08-03T13:35:37Z","file_size":8544,"success":1,"checksum":"4b389473cbf769e6e34670dae2224af1","date_updated":"2023-08-03T13:35:37Z","file_name":"Supplfig05_b_xy_1.png","file_id":"13746"},{"file_size":11135,"checksum":"b05aa1e201758a5d55e35d719452fafc","success":1,"date_updated":"2023-08-03T13:35:37Z","file_name":"Supplfig05_b_xy_2.png","file_id":"13747","relation":"main_file","creator":"jdanzl","access_level":"open_access","content_type":"image/png","date_created":"2023-08-03T13:35:37Z"},{"file_size":26762,"file_name":"Supplfig05_b_xy_3.png","file_id":"13748","date_updated":"2023-08-03T13:35:37Z","success":1,"checksum":"890f3516930251a367066c049141d6bb","access_level":"open_access","creator":"jdanzl","relation":"main_file","date_created":"2023-08-03T13:35:37Z","content_type":"image/png"},{"content_type":"image/png","date_created":"2023-08-03T13:35:37Z","access_level":"open_access","creator":"jdanzl","relation":"main_file","file_name":"Supplfig05_b_xy_4.png","file_id":"13749","date_updated":"2023-08-03T13:35:37Z","checksum":"36345c1d582758ff463072fd04578c0c","success":1,"file_size":8438},{"file_size":8434,"file_name":"Supplfig05_b_xy_5.png","file_id":"13750","date_updated":"2023-08-03T13:35:37Z","success":1,"checksum":"c9499ad8914c405a07fc4469b19e8987","access_level":"open_access","creator":"jdanzl","relation":"main_file","content_type":"image/png","date_created":"2023-08-03T13:35:37Z"},{"content_type":"image/png","date_created":"2023-08-03T13:35:37Z","relation":"main_file","creator":"jdanzl","access_level":"open_access","checksum":"7e7a7c900ce1fc3187ab648f207f9425","success":1,"date_updated":"2023-08-03T13:35:37Z","file_name":"Supplfig05_b_xz_1.png","file_id":"13751","file_size":8269},{"file_name":"Supplfig05_b_xz_2.png","file_id":"13752","date_updated":"2023-08-03T13:35:37Z","success":1,"checksum":"b645d1e2422ef3f05344ccd3f955468d","file_size":12762,"date_created":"2023-08-03T13:35:37Z","content_type":"image/png","access_level":"open_access","creator":"jdanzl","relation":"main_file"},{"date_updated":"2023-08-03T13:35:37Z","file_id":"13753","file_name":"Supplfig05_b_xz_3.png","checksum":"ef0b83b49cf47ca7d8ffe3bdc609fe38","success":1,"file_size":24819,"content_type":"image/png","date_created":"2023-08-03T13:35:37Z","access_level":"open_access","relation":"main_file","creator":"jdanzl"},{"file_name":"Supplfig05_b_xz_4.png","file_id":"13754","date_updated":"2023-08-03T13:35:37Z","success":1,"checksum":"68719d4d464a2ffc198cb6ad070c4579","file_size":8126,"date_created":"2023-08-03T13:35:37Z","content_type":"image/png","access_level":"open_access","creator":"jdanzl","relation":"main_file"},{"content_type":"image/png","date_created":"2023-08-03T13:35:38Z","access_level":"open_access","relation":"main_file","creator":"jdanzl","date_updated":"2023-08-03T13:35:38Z","file_id":"13755","file_name":"Supplfig05_b_xz_5.png","success":1,"checksum":"18370f47177ef37a477c6fd7bda3fea0","file_size":8114},{"date_created":"2023-08-03T13:35:38Z","content_type":"image/png","creator":"jdanzl","relation":"main_file","access_level":"open_access","checksum":"013d4bd9704ace490810b9ef21b12454","success":1,"file_name":"Supplfig05_c_xy_1.png","file_id":"13756","date_updated":"2023-08-03T13:35:38Z","file_size":8273},{"file_size":12639,"success":1,"checksum":"bb431f827386e79c54452d6284f501b9","date_updated":"2023-08-03T13:35:38Z","file_name":"Supplfig05_c_xy_2.png","file_id":"13757","relation":"main_file","creator":"jdanzl","access_level":"open_access","content_type":"image/png","date_created":"2023-08-03T13:35:38Z"},{"date_updated":"2023-08-03T13:35:38Z","file_id":"13758","file_name":"Supplfig05_c_xy_3.png","checksum":"4cd54f58c5afff88832a508655f913bb","success":1,"file_size":25288,"date_created":"2023-08-03T13:35:38Z","content_type":"image/png","access_level":"open_access","relation":"main_file","creator":"jdanzl"},{"checksum":"07f86f98f6a65eac8608cec8c567309e","success":1,"date_updated":"2023-08-03T13:35:38Z","file_id":"13759","file_name":"Supplfig05_c_xz_1.png","file_size":6786,"content_type":"image/png","date_created":"2023-08-03T13:35:38Z","relation":"main_file","creator":"jdanzl","access_level":"open_access"},{"success":1,"checksum":"492f699b71761214272b17432e3a54fa","file_name":"Supplfig05_c_xz_2.png","file_id":"13760","date_updated":"2023-08-03T13:35:38Z","file_size":9781,"content_type":"image/png","date_created":"2023-08-03T13:35:38Z","creator":"jdanzl","relation":"main_file","access_level":"open_access"},{"file_name":"Supplfig05_c_xz_3.png","file_id":"13761","date_updated":"2023-08-03T13:35:38Z","success":1,"checksum":"af617da5638db849bea6ff51a08227c6","file_size":20728,"content_type":"image/png","date_created":"2023-08-03T13:35:38Z","access_level":"open_access","creator":"jdanzl","relation":"main_file"},{"date_created":"2023-08-03T13:35:38Z","content_type":"image/png","access_level":"open_access","relation":"main_file","creator":"jdanzl","date_updated":"2023-08-03T13:35:38Z","file_name":"Supplfig05_d_xy_1.png","file_id":"13762","checksum":"5e5d5694af4a22297046d697a01fa4d6","success":1,"file_size":8428},{"date_created":"2023-08-03T13:35:38Z","content_type":"image/png","relation":"main_file","creator":"jdanzl","access_level":"open_access","success":1,"checksum":"38bf7b75f3dedd0a3722faae05aa0233","date_updated":"2023-08-03T13:35:38Z","file_name":"Supplfig05_d_xy_2.png","file_id":"13763","file_size":10813},{"content_type":"image/png","date_created":"2023-08-03T13:35:38Z","creator":"jdanzl","relation":"main_file","access_level":"open_access","checksum":"e4ea966553f158ec2cfbdc696780390e","success":1,"file_name":"Supplfig05_d_xy_3.png","file_id":"13764","date_updated":"2023-08-03T13:35:38Z","file_size":26552},{"date_created":"2023-08-03T13:35:38Z","content_type":"image/png","access_level":"open_access","relation":"main_file","creator":"jdanzl","date_updated":"2023-08-03T13:35:38Z","file_name":"Supplfig05_d_xz_1.png","file_id":"13765","checksum":"356f424d9f5f608e9aea962bb63672f1","success":1,"file_size":7876},{"creator":"jdanzl","relation":"main_file","access_level":"open_access","content_type":"image/png","date_created":"2023-08-03T13:35:38Z","file_size":11634,"success":1,"checksum":"05068476beee0f394e28b98209686394","file_id":"13766","file_name":"Supplfig05_d_xz_2.png","date_updated":"2023-08-03T13:35:38Z"},{"date_created":"2023-08-03T13:35:38Z","content_type":"image/png","relation":"main_file","creator":"jdanzl","access_level":"open_access","success":1,"checksum":"78b3a0d93df22383a384a2f3acc80401","date_updated":"2023-08-03T13:35:38Z","file_name":"Supplfig05_d_xz_3.png","file_id":"13767","file_size":25006},{"file_size":7895,"date_updated":"2023-08-03T13:35:38Z","file_id":"13768","file_name":"Supplfig05_e_xy_1.png","checksum":"f5ee6a817f11a42c9db82ad6325f58b9","success":1,"access_level":"open_access","relation":"main_file","creator":"jdanzl","date_created":"2023-08-03T13:35:38Z","content_type":"image/png"},{"creator":"jdanzl","relation":"main_file","access_level":"open_access","date_created":"2023-08-03T13:35:38Z","content_type":"image/png","file_size":6180,"checksum":"019ca89e892d6e19589609bc99eab331","success":1,"file_id":"13769","file_name":"Supplfig05_e_xy_2.png","date_updated":"2023-08-03T13:35:38Z"},{"checksum":"0e1a5cbbd70dc245edaecaca70d974cb","success":1,"date_updated":"2023-08-03T13:35:38Z","file_name":"Supplfig05_e_xy_3.png","file_id":"13770","file_size":18326,"content_type":"image/png","date_created":"2023-08-03T13:35:38Z","relation":"main_file","creator":"jdanzl","access_level":"open_access"},{"file_size":6295,"date_updated":"2023-08-03T13:35:38Z","file_name":"Supplfig05_e_xz_1.png","file_id":"13771","success":1,"checksum":"4d4d64a5bb7b096aaf8130ece4512bc2","access_level":"open_access","relation":"main_file","creator":"jdanzl","content_type":"image/png","date_created":"2023-08-03T13:35:38Z"},{"file_size":4335,"date_updated":"2023-08-03T13:35:38Z","file_name":"Supplfig05_e_xz_2.png","file_id":"13772","success":1,"checksum":"607302aec5ec2a14a271dbffd3465261","access_level":"open_access","relation":"main_file","creator":"jdanzl","content_type":"image/png","date_created":"2023-08-03T13:35:38Z"},{"file_name":"Supplfig05_e_xz_3.png","file_id":"13773","date_updated":"2023-08-03T13:35:38Z","success":1,"checksum":"a673e17ead1fd2e776b9a5f560a289ab","file_size":23243,"date_created":"2023-08-03T13:35:38Z","content_type":"image/png","access_level":"open_access","creator":"jdanzl","relation":"main_file"},{"file_name":"Supplfig06_a_1.tif","file_id":"13774","date_updated":"2023-08-03T13:46:13Z","success":1,"checksum":"4349e511fc86a8bddb790a7be7175c75","file_size":4002153,"content_type":"image/tiff","date_created":"2023-08-03T13:46:13Z","access_level":"open_access","creator":"jdanzl","relation":"main_file"},{"relation":"main_file","creator":"jdanzl","access_level":"open_access","content_type":"image/tiff","date_created":"2023-08-03T13:46:13Z","file_size":2252137,"checksum":"cd12977e4c1a472d80193be01f69a895","success":1,"date_updated":"2023-08-03T13:46:13Z","file_name":"Supplfig06_a_2.tif","file_id":"13775"},{"access_level":"open_access","relation":"main_file","creator":"jdanzl","content_type":"image/tiff","date_created":"2023-08-03T13:46:13Z","file_size":2252137,"date_updated":"2023-08-03T13:46:13Z","file_name":"Supplfig06_a_3.tif","file_id":"13776","success":1,"checksum":"575e32b8c25ce658e20f0c86a5f1b9b7"},{"file_name":"Supplfig06_a_i.tif","file_id":"13777","date_updated":"2023-08-03T13:46:13Z","checksum":"b06f775e0210e7a16cb4b58aed32118c","success":1,"file_size":78329,"date_created":"2023-08-03T13:46:13Z","content_type":"image/tiff","access_level":"open_access","creator":"jdanzl","relation":"main_file"},{"relation":"main_file","creator":"jdanzl","access_level":"open_access","content_type":"image/tiff","date_created":"2023-08-03T13:46:13Z","file_size":78329,"success":1,"checksum":"56854c1a05c721c36877fe7c7454b7d7","date_updated":"2023-08-03T13:46:13Z","file_name":"Supplfig06_a_ii.tif","file_id":"13778"},{"date_created":"2023-08-03T13:46:13Z","content_type":"image/tiff","creator":"jdanzl","relation":"main_file","access_level":"open_access","success":1,"checksum":"9aff42ea5138931fedb5a00643ae7a22","file_id":"13779","file_name":"Supplfig06_a_iii.tif","date_updated":"2023-08-03T13:46:13Z","file_size":78329},{"checksum":"9474b7d00d4dee46659afedef75dc095","success":1,"file_name":"Supplfig06_d_1.tif","file_id":"13780","date_updated":"2023-08-03T13:46:13Z","file_size":501149,"content_type":"image/tiff","date_created":"2023-08-03T13:46:13Z","creator":"jdanzl","relation":"main_file","access_level":"open_access"},{"access_level":"open_access","creator":"jdanzl","relation":"main_file","content_type":"image/tiff","date_created":"2023-08-03T13:46:13Z","file_size":500153,"file_name":"Supplfig06_d_2.tif","file_id":"13781","date_updated":"2023-08-03T13:46:13Z","success":1,"checksum":"53df41dd968b04b4657cd2b91870d636"},{"access_level":"open_access","relation":"main_file","creator":"jdanzl","date_created":"2023-08-03T13:46:14Z","content_type":"image/tiff","file_size":500153,"date_updated":"2023-08-03T13:46:14Z","file_name":"Supplfig06_d_3.tif","file_id":"13782","checksum":"1a39b8310598dd25d97f848b682b8de0","success":1},{"checksum":"6d9b496be6aecedbb2cb4cbf68f02872","success":1,"date_updated":"2023-08-03T13:46:14Z","file_id":"13783","file_name":"Supplfig06_d_i.tif","file_size":78329,"date_created":"2023-08-03T13:46:14Z","content_type":"image/tiff","relation":"main_file","creator":"jdanzl","access_level":"open_access"},{"date_created":"2023-08-03T13:46:14Z","content_type":"image/tiff","creator":"jdanzl","relation":"main_file","access_level":"open_access","success":1,"checksum":"bc034b1636c2db8b9d9e7bd131b9780a","file_id":"13784","file_name":"Supplfig06_d_ii.tif","date_updated":"2023-08-03T13:46:14Z","file_size":78329},{"file_size":78329,"file_name":"Supplfig06_d_iii.tif","file_id":"13785","date_updated":"2023-08-03T13:46:14Z","checksum":"54f6e55e30a2aeea6c82eb6dbd376240","success":1,"access_level":"open_access","creator":"jdanzl","relation":"main_file","content_type":"image/tiff","date_created":"2023-08-03T13:46:14Z"},{"access_level":"open_access","creator":"jdanzl","relation":"main_file","date_created":"2023-08-03T13:46:14Z","content_type":"image/tiff","file_size":960011,"file_name":"Supplfig06_g_1.tif","file_id":"13786","date_updated":"2023-08-03T13:46:14Z","checksum":"446da3cc16897277890f23f966c2bf52","success":1},{"file_size":960011,"success":1,"checksum":"71192d0ec592a33195f2386a5f95aa86","date_updated":"2023-08-03T13:46:14Z","file_id":"13787","file_name":"Supplfig06_g_2.tif","relation":"main_file","creator":"jdanzl","access_level":"open_access","date_created":"2023-08-03T13:46:14Z","content_type":"image/tiff"},{"success":1,"checksum":"246782dbe8ff525aea360efc72e65f07","file_id":"13788","file_name":"Supplfig06_g_3.tif","date_updated":"2023-08-03T13:46:14Z","file_size":960041,"content_type":"image/tiff","date_created":"2023-08-03T13:46:14Z","creator":"jdanzl","relation":"main_file","access_level":"open_access"},{"file_size":960041,"date_updated":"2023-08-03T13:46:14Z","file_name":"Supplfig06_g_4.tif","file_id":"13789","checksum":"d49b12fec5508aa8d72587757cccc0a4","success":1,"access_level":"open_access","relation":"main_file","creator":"jdanzl","date_created":"2023-08-03T13:46:14Z","content_type":"image/tiff"},{"success":1,"checksum":"27b11b1d4fc784a49ffd7660624d00b6","date_updated":"2023-08-03T13:46:14Z","file_id":"13790","file_name":"Supplfig06_g_5.tif","file_size":963241,"date_created":"2023-08-03T13:46:14Z","content_type":"image/tiff","relation":"main_file","creator":"jdanzl","access_level":"open_access"},{"creator":"jdanzl","relation":"main_file","access_level":"open_access","content_type":"image/tiff","date_created":"2023-08-03T13:51:38Z","file_size":19286002,"success":1,"checksum":"9ce944049c1b88fadbf43609385f9e2f","file_id":"13791","file_name":"Suppl08_a_1.tiff","date_updated":"2023-08-03T13:51:38Z"},{"success":1,"checksum":"06265515f06688843a415362f7b2c485","date_updated":"2023-08-03T13:51:38Z","file_name":"Suppl08_a_2.tiff","file_id":"13792","file_size":19286002,"date_created":"2023-08-03T13:51:38Z","content_type":"image/tiff","relation":"main_file","creator":"jdanzl","access_level":"open_access"},{"success":1,"checksum":"50f0969c6c2c1209ff776bec4861030a","file_id":"13793","file_name":"Suppl08_a_3.tif","date_updated":"2023-08-03T13:51:38Z","file_size":617552,"content_type":"image/tiff","date_created":"2023-08-03T13:51:38Z","creator":"jdanzl","relation":"main_file","access_level":"open_access"},{"relation":"main_file","creator":"jdanzl","access_level":"open_access","date_created":"2023-08-03T13:51:38Z","content_type":"image/tiff","file_size":617552,"checksum":"b90965d20133fea73c99050c32eb7695","success":1,"date_updated":"2023-08-03T13:51:38Z","file_name":"Suppl08_a_4.tif","file_id":"13794"},{"date_created":"2023-08-03T13:51:40Z","content_type":"image/tiff","access_level":"open_access","creator":"jdanzl","relation":"main_file","file_name":"Suppl08_a_coCATS_N2V.tif","file_id":"13795","date_updated":"2023-08-03T13:51:40Z","success":1,"checksum":"568a1e0efaa62527b51e66a7aabfd05c","file_size":19287339},{"checksum":"06265515f06688843a415362f7b2c485","success":1,"date_updated":"2023-08-03T13:51:40Z","file_name":"Suppl08_c_1_4_predictedBASSOON.tiff","file_id":"13796","file_size":19286002,"content_type":"image/tiff","date_created":"2023-08-03T13:51:40Z","relation":"main_file","creator":"jdanzl","access_level":"open_access"},{"access_level":"open_access","creator":"jdanzl","relation":"main_file","content_type":"image/tiff","date_created":"2023-08-03T13:51:43Z","file_size":19287339,"file_id":"13797","file_name":"Suppl08_c_1_coCATS.tif","date_updated":"2023-08-03T13:51:43Z","checksum":"568a1e0efaa62527b51e66a7aabfd05c","success":1},{"date_created":"2023-08-03T15:36:47Z","content_type":"image/tiff","creator":"jdanzl","relation":"main_file","access_level":"open_access","checksum":"feae08c38b1d9c540b697977cd7f2666","success":1,"file_name":"Suppl08_c_2_coCATS.tif","file_id":"13798","date_updated":"2023-08-03T15:36:47Z","file_size":19287340},{"content_type":"image/tiff","date_created":"2023-08-03T13:51:44Z","access_level":"open_access","relation":"main_file","creator":"jdanzl","date_updated":"2023-08-03T13:51:44Z","file_id":"13799","file_name":"Suppl08_c_2-3_predictedBASSOON.tiff","checksum":"af2c1199fdcaecfec76189dae86cc12e","success":1,"file_size":19286002},{"relation":"main_file","creator":"jdanzl","access_level":"open_access","content_type":"application/octet-stream","date_created":"2023-08-03T13:51:43Z","file_size":156,"success":1,"checksum":"1f92db47605959d0db01f612f7c9c034","date_updated":"2023-08-03T13:51:43Z","file_id":"13800","file_name":"Suppl08_c_3-6_roi.roi"},{"content_type":"image/tiff","date_created":"2023-08-03T13:51:45Z","creator":"jdanzl","relation":"main_file","access_level":"open_access","checksum":"4fc4f8803adcfacd53a41b91f4699dc5","success":1,"file_name":"Suppl08_e_1_3.tiff","file_id":"13801","date_updated":"2023-08-03T13:51:45Z","file_size":19286002},{"date_updated":"2023-08-03T13:51:45Z","file_id":"13802","file_name":"Suppl08_e_1-2.tiff","checksum":"459551aae114daa4f5ca5d06fcd6b203","success":1,"file_size":19286002,"date_created":"2023-08-03T13:51:45Z","content_type":"image/tiff","access_level":"open_access","relation":"main_file","creator":"jdanzl"},{"file_size":152,"file_id":"13803","file_name":"Suppl08_e_2-5_roi.roi","date_updated":"2023-08-03T13:51:45Z","success":1,"checksum":"032cbace7ec436f7b62478c0ffd35e5e","access_level":"open_access","creator":"jdanzl","relation":"main_file","date_created":"2023-08-03T13:51:45Z","content_type":"application/octet-stream"},{"access_level":"open_access","creator":"jdanzl","relation":"main_file","content_type":"image/tiff","date_created":"2023-08-03T13:51:46Z","file_size":19286002,"file_id":"13804","file_name":"Suppl08_e_4-5_coCATS.tiff","date_updated":"2023-08-03T13:51:46Z","checksum":"7379168be281ef618b8cecd8efd31ed5","success":1},{"file_id":"13805","file_name":"Suppl08_e_4.tif","date_updated":"2023-08-03T13:51:46Z","success":1,"checksum":"5c4c092f608f4c10bb422c9e08b5955b","file_size":617552,"date_created":"2023-08-03T13:51:46Z","content_type":"image/tiff","access_level":"open_access","creator":"jdanzl","relation":"main_file"},{"file_size":617552,"file_name":"Suppl08_e_5.tif","file_id":"13806","date_updated":"2023-08-03T13:51:46Z","success":1,"checksum":"903e31be124f6e4ec1c2e7ab7db80e6b","access_level":"open_access","creator":"jdanzl","relation":"main_file","date_created":"2023-08-03T13:51:46Z","content_type":"image/tiff"},{"creator":"jdanzl","relation":"main_file","access_level":"open_access","date_created":"2023-08-03T13:51:48Z","content_type":"image/tiff","file_size":19286002,"checksum":"173d956392d67b0a7e544629b51881e4","success":1,"file_id":"13807","file_name":"Suppl08_e_6_8.tiff","date_updated":"2023-08-03T13:51:48Z"},{"content_type":"image/tiff","date_created":"2023-08-03T13:51:48Z","access_level":"open_access","creator":"jdanzl","relation":"main_file","file_name":"Suppl08_e_6-7.tiff","file_id":"13808","date_updated":"2023-08-03T13:51:48Z","checksum":"2a4cea867a253a6af7e9b0d2e100de14","success":1,"file_size":19286002},{"file_size":174,"checksum":"6b40f99fddfa26f0a9713000769741b7","success":1,"date_updated":"2023-08-03T13:51:48Z","file_id":"13809","file_name":"Suppl08_e_7-10_roi.roi","relation":"main_file","creator":"jdanzl","access_level":"open_access","date_created":"2023-08-03T13:51:48Z","content_type":"application/octet-stream"},{"file_size":19286002,"date_updated":"2023-08-03T13:51:49Z","file_id":"13810","file_name":"Suppl08_e_9-10_coCATS.tiff","success":1,"checksum":"82f7013959df99c27366886de9b38ba2","access_level":"open_access","relation":"main_file","creator":"jdanzl","date_created":"2023-08-03T13:51:49Z","content_type":"image/tiff"},{"date_updated":"2023-08-03T13:51:48Z","file_id":"13811","file_name":"Suppl08_e_9.tif","success":1,"checksum":"50f0969c6c2c1209ff776bec4861030a","file_size":617552,"date_created":"2023-08-03T13:51:48Z","content_type":"image/tiff","access_level":"open_access","relation":"main_file","creator":"jdanzl"},{"file_size":617552,"checksum":"569f599d7f2be49d4dcf7cb385f428c4","success":1,"date_updated":"2023-08-03T13:51:49Z","file_id":"13812","file_name":"Suppl08_e_10.tif","relation":"main_file","creator":"jdanzl","access_level":"open_access","content_type":"image/tiff","date_created":"2023-08-03T13:51:49Z"},{"content_type":"image/tiff","date_created":"2023-08-03T13:51:49Z","creator":"jdanzl","relation":"main_file","access_level":"open_access","success":1,"checksum":"50f0969c6c2c1209ff776bec4861030a","file_name":"Suppl08_g_1.tif","file_id":"13813","date_updated":"2023-08-03T13:51:49Z","file_size":617552},{"content_type":"image/tiff","date_created":"2023-08-03T13:51:49Z","relation":"main_file","creator":"jdanzl","access_level":"open_access","success":1,"checksum":"62797fc860176197142a47e831eaf1f6","date_updated":"2023-08-03T13:51:49Z","file_name":"Suppl08_g_2.tif","file_id":"13814","file_size":617552},{"date_created":"2023-08-03T13:51:49Z","content_type":"image/tiff","access_level":"open_access","creator":"jdanzl","relation":"main_file","file_id":"13815","file_name":"Suppl08_g_3.tif","date_updated":"2023-08-03T13:51:49Z","checksum":"b90965d20133fea73c99050c32eb7695","success":1,"file_size":617552},{"content_type":"application/octet-stream","date_created":"2023-08-03T13:51:49Z","access_level":"open_access","relation":"main_file","creator":"jdanzl","date_updated":"2023-08-03T13:51:49Z","file_name":"Suppl08_i_add_roi.roi","file_id":"13816","checksum":"a96dc9f38c6a1d3c959771a649a42748","success":1,"file_size":160},{"relation":"main_file","creator":"jdanzl","access_level":"open_access","date_created":"2023-08-03T13:51:50Z","content_type":"application/octet-stream","file_size":160,"success":1,"checksum":"f2135207ebbc4bdc014763ba852a5cf0","date_updated":"2023-08-03T13:51:50Z","file_name":"Suppl08_i_shape_roi.roi","file_id":"13817"},{"file_size":158,"file_name":"Suppl08_i_split_roi.roi","file_id":"13818","date_updated":"2023-08-03T13:51:50Z","success":1,"checksum":"f6f31fe2d87cf7208387f98ce1e37b04","access_level":"open_access","creator":"jdanzl","relation":"main_file","content_type":"application/octet-stream","date_created":"2023-08-03T13:51:50Z"},{"success":1,"checksum":"71590db0ad391e0c5baf03024981b1d9","file_id":"13819","file_name":"Suppl08_i_1.tiff","date_updated":"2023-08-03T13:51:51Z","file_size":19286002,"date_created":"2023-08-03T13:51:51Z","content_type":"image/tiff","creator":"jdanzl","relation":"main_file","access_level":"open_access"},{"content_type":"image/tiff","date_created":"2023-08-03T13:51:51Z","access_level":"open_access","creator":"jdanzl","relation":"main_file","file_name":"Suppl08_i_2.tiff","file_id":"13820","date_updated":"2023-08-03T13:51:51Z","checksum":"9ce944049c1b88fadbf43609385f9e2f","success":1,"file_size":19286002},{"file_size":19286002,"checksum":"06265515f06688843a415362f7b2c485","success":1,"file_id":"13821","file_name":"Suppl08_i_3.tiff","date_updated":"2023-08-03T13:51:52Z","creator":"jdanzl","relation":"main_file","access_level":"open_access","date_created":"2023-08-03T13:51:52Z","content_type":"image/tiff"},{"creator":"jdanzl","relation":"main_file","access_level":"open_access","content_type":"image/tiff","date_created":"2023-08-03T13:51:52Z","file_size":19284766,"checksum":"16c628c160fb81e40df0ad1eb134e92b","success":1,"file_name":"Suppl08_i_4.tif","file_id":"13822","date_updated":"2023-08-03T13:51:52Z"},{"relation":"main_file","creator":"jdanzl","access_level":"open_access","content_type":"image/tiff","date_created":"2023-08-03T13:51:53Z","file_size":9649818,"success":1,"checksum":"b06e62c3a9834a40002d7aad3eaacc3f","date_updated":"2023-08-03T13:51:53Z","file_name":"Suppl08_i_5.tif","file_id":"13823"},{"content_type":"image/tiff","date_created":"2023-08-03T13:51:53Z","access_level":"open_access","relation":"main_file","creator":"jdanzl","date_updated":"2023-08-03T13:51:53Z","file_name":"Suppl08_i_6.tif","file_id":"13824","checksum":"41ef98c7f01755b43cf6e77fff287732","success":1,"file_size":19284766},{"file_id":"13825","file_name":"Suppl08_c_2_coCATS.tif","date_updated":"2023-08-03T13:53:29Z","success":1,"checksum":"feae08c38b1d9c540b697977cd7f2666","file_size":19287340,"content_type":"image/tiff","date_created":"2023-08-03T13:53:29Z","access_level":"open_access","creator":"jdanzl","relation":"main_file"},{"content_type":"image/tiff","date_created":"2023-08-03T13:58:08Z","access_level":"open_access","relation":"main_file","creator":"jdanzl","date_updated":"2023-08-03T13:58:08Z","file_id":"13826","file_name":"Supplfig09_b_1_n2v.tiff","success":1,"checksum":"c01509a1c657fbbbfdbbd484c298b6e3","file_size":179788642},{"file_size":742420240,"file_id":"13827","file_name":"Supplfig09_b_2_n2v.tif","date_updated":"2023-08-03T13:58:20Z","checksum":"64a7f270274ff3480b18d690087016e2","success":1,"access_level":"open_access","creator":"jdanzl","relation":"main_file","date_created":"2023-08-03T13:58:20Z","content_type":"image/tiff"},{"file_size":478900363,"date_updated":"2023-08-03T13:58:20Z","file_id":"13828","file_name":"Supplfig09_b_3_n2v.tif","checksum":"b34a6beaaf13698f421df961e009efeb","success":1,"access_level":"open_access","relation":"main_file","creator":"jdanzl","content_type":"image/tiff","date_created":"2023-08-03T13:58:20Z"},{"date_created":"2023-08-03T13:58:25Z","content_type":"image/tiff","access_level":"open_access","relation":"main_file","creator":"jdanzl","date_updated":"2023-08-03T13:58:25Z","file_id":"13829","file_name":"Supplfig09_b_4_n2v.tif","success":1,"checksum":"ec04501f234b5e4fd91f9eac0e585395","file_size":191873159},{"checksum":"3a1b313298da35c97550abf0d245b4a7","success":1,"file_id":"13830","file_name":"Supplfig11_i.tif","date_updated":"2023-08-03T13:59:27Z","file_size":55286,"content_type":"image/tiff","date_created":"2023-08-03T13:59:27Z","creator":"jdanzl","relation":"main_file","access_level":"open_access"},{"file_name":"Supplfig11_ii.tif","file_id":"13831","date_updated":"2023-08-03T13:59:27Z","success":1,"checksum":"9cf00c0252f0a2efe1994c83c224389a","file_size":55286,"date_created":"2023-08-03T13:59:27Z","content_type":"image/tiff","access_level":"open_access","creator":"jdanzl","relation":"main_file"},{"file_name":"Supplfig11_iii.tif","file_id":"13832","date_updated":"2023-08-03T13:59:27Z","success":1,"checksum":"9a6e83acdf6d70bb9a6e76fa7d41a372","file_size":55257,"content_type":"image/tiff","date_created":"2023-08-03T13:59:27Z","access_level":"open_access","creator":"jdanzl","relation":"main_file"},{"relation":"main_file","creator":"jdanzl","access_level":"open_access","date_created":"2023-08-03T13:59:32Z","content_type":"image/tiff","file_size":309457551,"success":1,"checksum":"709fdd13b7e090846a4d8edd2425f675","date_updated":"2023-08-03T13:59:32Z","file_name":"Supplfig11_n2v+prediction.tif","file_id":"13833"},{"file_id":"13834","file_name":"Supplfig12_a_01_n2v.tif","date_updated":"2023-08-03T14:14:32Z","checksum":"e60ea3e6bb1bf380460d0d8ccdbd1f07","success":1,"file_size":119323629,"date_created":"2023-08-03T14:14:32Z","content_type":"image/tiff","access_level":"open_access","creator":"jdanzl","relation":"main_file"},{"creator":"jdanzl","relation":"main_file","access_level":"open_access","date_created":"2023-08-03T14:14:29Z","content_type":"image/tiff","file_size":59680727,"success":1,"checksum":"2a4e1771e2f06383894361ba2a8155b4","file_name":"Supplfig12_a_01.tif","file_id":"13835","date_updated":"2023-08-03T14:14:29Z"},{"file_name":"Supplfig12_a_02_n2v.tif","file_id":"13836","date_updated":"2023-08-03T14:14:34Z","checksum":"993c434069b9d1bcb09bfe70628f5bbe","success":1,"file_size":106696749,"date_created":"2023-08-03T14:14:34Z","content_type":"image/tiff","access_level":"open_access","creator":"jdanzl","relation":"main_file"},{"file_size":53367287,"success":1,"checksum":"e3b6410d68e42004ef3857967707aeb3","date_updated":"2023-08-03T14:14:34Z","file_name":"Supplfig12_a_02.tif","file_id":"13837","relation":"main_file","creator":"jdanzl","access_level":"open_access","content_type":"image/tiff","date_created":"2023-08-03T14:14:34Z"},{"file_size":149937979,"checksum":"0156e99806fe1539d5f48ea16c78e8c8","success":1,"date_updated":"2023-08-03T14:14:41Z","file_name":"Supplfig12_a_03_n2v.tif","file_id":"13838","relation":"main_file","creator":"jdanzl","access_level":"open_access","date_created":"2023-08-03T14:14:41Z","content_type":"image/tiff"},{"access_level":"open_access","relation":"main_file","creator":"jdanzl","date_created":"2023-08-03T14:14:39Z","content_type":"image/tiff","file_size":74987927,"date_updated":"2023-08-03T14:14:39Z","file_id":"13839","file_name":"Supplfig12_a_03.tif","success":1,"checksum":"6cc1533a221526a072a0b09fb44bcf50"},{"file_size":305581862,"file_name":"Supplfig12_a_04_n2v.tif","file_id":"13840","date_updated":"2023-08-03T14:14:53Z","checksum":"f134834bd0d5e8c22e5a35aadf592007","success":1,"access_level":"open_access","creator":"jdanzl","relation":"main_file","content_type":"image/tiff","date_created":"2023-08-03T14:14:53Z"},{"access_level":"open_access","creator":"jdanzl","relation":"main_file","date_created":"2023-08-03T14:14:50Z","content_type":"image/tiff","file_size":152821840,"file_name":"Supplfig12_a_04.tif","file_id":"13841","date_updated":"2023-08-03T14:14:50Z","checksum":"212ec76c02552fa1eef91e7bca9f07f7","success":1},{"date_updated":"2023-08-03T14:14:52Z","file_id":"13842","file_name":"Supplfig12_a_05_n2v.tif","success":1,"checksum":"7d99807d5b4313b04b4b5e0fbc08ba78","file_size":48082029,"date_created":"2023-08-03T14:14:52Z","content_type":"image/tiff","access_level":"open_access","relation":"main_file","creator":"jdanzl"},{"content_type":"image/tiff","date_created":"2023-08-03T14:14:53Z","relation":"main_file","creator":"jdanzl","access_level":"open_access","success":1,"checksum":"a6d4024a8c6fa073a532cc0c78323df7","date_updated":"2023-08-03T14:14:53Z","file_name":"Supplfig12_a_05.tif","file_id":"13843","file_size":24059983},{"file_size":305581860,"checksum":"1c42ad5423636478fe57495a3b506746","success":1,"date_updated":"2023-08-03T14:15:09Z","file_id":"13844","file_name":"Supplfig12_a_06_n2v.tif","relation":"main_file","creator":"jdanzl","access_level":"open_access","content_type":"image/tiff","date_created":"2023-08-03T14:15:09Z"},{"date_created":"2023-08-03T14:15:04Z","content_type":"image/tiff","access_level":"open_access","relation":"main_file","creator":"jdanzl","date_updated":"2023-08-03T14:15:04Z","file_name":"Supplfig12_a_06.tif","file_id":"13845","checksum":"821f1d31c6dbe68eb2513fb7520b5272","success":1,"file_size":152821840},{"file_size":66855793,"file_id":"13846","file_name":"Supplfig12_a_07_n2v.tif","date_updated":"2023-08-03T14:15:08Z","checksum":"86a4dc1e4948c4bc9c71e6d55b4fd104","success":1,"access_level":"open_access","creator":"jdanzl","relation":"main_file","content_type":"image/tiff","date_created":"2023-08-03T14:15:08Z"},{"date_created":"2023-08-03T14:15:09Z","content_type":"image/tiff","relation":"main_file","creator":"jdanzl","access_level":"open_access","checksum":"fd5d45b1135800124fec635c4667dafe","success":1,"date_updated":"2023-08-03T14:15:09Z","file_name":"Supplfig12_a_07.tif","file_id":"13847","file_size":33446807},{"access_level":"open_access","creator":"jdanzl","relation":"main_file","content_type":"image/tiff","date_created":"2023-08-03T14:15:19Z","file_size":231476260,"file_name":"Supplfig12_a_08_n2v.tif","file_id":"13848","date_updated":"2023-08-03T14:15:19Z","checksum":"5683760cc119a09f0b7de8fea98cda9c","success":1},{"success":1,"checksum":"0c336d554bcd8524f11bd25c2188b56f","file_id":"13849","file_name":"Supplfig12_a_08.tif","date_updated":"2023-08-03T14:15:15Z","file_size":115769040,"content_type":"image/tiff","date_created":"2023-08-03T14:15:15Z","creator":"jdanzl","relation":"main_file","access_level":"open_access"},{"success":1,"checksum":"fcaea6c95c363bd864a524fca8ed8e9b","file_id":"13850","file_name":"Supplfig12_a_09_n2v.tif","date_updated":"2023-08-03T14:15:31Z","file_size":305581869,"content_type":"image/tiff","date_created":"2023-08-03T14:15:31Z","creator":"jdanzl","relation":"main_file","access_level":"open_access"},{"date_updated":"2023-08-03T14:15:28Z","file_name":"Supplfig12_a_09.tif","file_id":"13851","success":1,"checksum":"f401f1875f072c345d106a1e419f9d13","file_size":152821840,"content_type":"image/tiff","date_created":"2023-08-03T14:15:28Z","access_level":"open_access","relation":"main_file","creator":"jdanzl"},{"access_level":"open_access","creator":"jdanzl","relation":"main_file","date_created":"2023-08-03T14:15:42Z","content_type":"image/tiff","file_size":266386255,"file_id":"13852","file_name":"Supplfig12_a_10_n2v.tif","date_updated":"2023-08-03T14:15:42Z","checksum":"7ad7d5b1ac81da1ec3d5003d00ee870a","success":1},{"file_size":133239040,"checksum":"77b93d082debd5248348c0a1e886eab9","success":1,"file_name":"Supplfig12_a_10.tif","file_id":"13853","date_updated":"2023-08-03T14:15:40Z","creator":"jdanzl","relation":"main_file","access_level":"open_access","content_type":"image/tiff","date_created":"2023-08-03T14:15:40Z"},{"success":1,"checksum":"5ece1d503f05133d07d5b867f666d7a8","file_name":"Supplfig12_a_11_n2v.tif","file_id":"13854","date_updated":"2023-08-03T14:15:49Z","file_size":191866269,"date_created":"2023-08-03T14:15:49Z","content_type":"image/tiff","creator":"jdanzl","relation":"main_file","access_level":"open_access"},{"file_size":95955040,"date_updated":"2023-08-03T14:15:48Z","file_id":"13855","file_name":"Supplfig12_a_11.tif","checksum":"a72ee7ab433097752ff00a63421d4b61","success":1,"access_level":"open_access","relation":"main_file","creator":"jdanzl","date_created":"2023-08-03T14:15:48Z","content_type":"image/tiff"},{"content_type":"image/tiff","date_created":"2023-08-03T14:16:49Z","relation":"main_file","creator":"jdanzl","access_level":"open_access","success":1,"checksum":"c9c6e4692e0e7f305a43058b201b50d3","date_updated":"2023-08-03T14:16:49Z","file_name":"Supplfig13_i.tif","file_id":"13856","file_size":55281},{"relation":"main_file","creator":"jdanzl","access_level":"open_access","content_type":"image/tiff","date_created":"2023-08-03T14:16:49Z","file_size":55193,"checksum":"345d11dbd70123d9d2723b547cbfc4fc","success":1,"date_updated":"2023-08-03T14:16:49Z","file_name":"Supplfig13_ii.tif","file_id":"13857"},{"checksum":"b4c74c08077cfd3e11bfd6ea9ee1c5b2","success":1,"file_name":"Supplfig13_n2v+predict.tif","file_id":"13858","date_updated":"2023-08-03T14:16:49Z","file_size":539037,"date_created":"2023-08-03T14:16:49Z","content_type":"image/tiff","creator":"jdanzl","relation":"main_file","access_level":"open_access"},{"file_size":854898609,"file_id":"13859","file_name":"Supplfig14_a_n2v.tif","date_updated":"2023-08-03T14:18:10Z","checksum":"15f5b44257d075f9e45811304dfd5f85","success":1,"access_level":"open_access","creator":"jdanzl","relation":"main_file","date_created":"2023-08-03T14:18:10Z","content_type":"image/tiff"},{"date_updated":"2023-08-03T14:19:58Z","file_id":"13860","file_name":"Supplfig15_a_1.png","success":1,"checksum":"a9ca03e3e5696988d06fc6ab1c103440","file_size":7514502,"date_created":"2023-08-03T14:19:58Z","content_type":"image/png","access_level":"open_access","relation":"main_file","creator":"jdanzl"},{"date_updated":"2023-08-03T14:19:58Z","file_id":"13861","file_name":"Supplfig15_a_2.png","checksum":"4be3451e203a0fc5d9eb14279ff68a7a","success":1,"file_size":1784041,"content_type":"image/png","date_created":"2023-08-03T14:19:58Z","access_level":"open_access","relation":"main_file","creator":"jdanzl"},{"access_level":"open_access","relation":"main_file","creator":"jdanzl","content_type":"image/tiff","date_created":"2023-08-03T14:19:58Z","file_size":6030878,"date_updated":"2023-08-03T14:19:58Z","file_id":"13862","file_name":"Supplfig15_b_1.tif","checksum":"43068c31eecddb798dbf2f51bda9b6c9","success":1},{"relation":"main_file","creator":"jdanzl","access_level":"open_access","content_type":"image/tiff","date_created":"2023-08-03T14:19:58Z","file_size":723293,"success":1,"checksum":"ded4c0797f1a9152dc3128f1bb8c32a5","date_updated":"2023-08-03T14:19:58Z","file_name":"Supplfig15_b_2.tif","file_id":"13863"},{"file_size":723409,"success":1,"checksum":"705394732d94bd8463479aee83c2d36e","date_updated":"2023-08-03T14:19:58Z","file_id":"13864","file_name":"Supplfig15_c_i.tif","relation":"main_file","creator":"jdanzl","access_level":"open_access","date_created":"2023-08-03T14:19:58Z","content_type":"image/tiff"},{"date_created":"2023-08-03T14:19:58Z","content_type":"image/tiff","access_level":"open_access","relation":"main_file","creator":"jdanzl","date_updated":"2023-08-03T14:19:58Z","file_name":"Supplfig15_c_ii.tif","file_id":"13865","success":1,"checksum":"e08efe220bec6a93d583cab17754dd19","file_size":723409},{"success":1,"checksum":"0e08e5d965815240b0a8195e0f899aab","file_id":"13866","file_name":"Supplfig15_c.tif","date_updated":"2023-08-03T14:19:59Z","file_size":31572914,"date_created":"2023-08-03T14:19:59Z","content_type":"image/tiff","creator":"jdanzl","relation":"main_file","access_level":"open_access"},{"access_level":"open_access","relation":"main_file","creator":"jdanzl","content_type":"image/tiff","date_created":"2023-08-03T14:19:59Z","file_size":6030752,"date_updated":"2023-08-03T14:19:59Z","file_id":"13867","file_name":"Supplfig15_d_1.tif","success":1,"checksum":"594696a77d4a9be512046be5e2d602f0"},{"file_name":"Supplfig15_d_2.tif","file_id":"13868","date_updated":"2023-08-03T14:19:59Z","success":1,"checksum":"ffe6733eb77858008c4ca07b5f8c432b","file_size":8005495,"content_type":"image/tiff","date_created":"2023-08-03T14:19:59Z","access_level":"open_access","creator":"jdanzl","relation":"main_file"},{"access_level":"open_access","creator":"jdanzl","relation":"main_file","content_type":"image/tiff","date_created":"2023-08-03T14:20:56Z","file_size":11117709,"file_id":"13869","file_name":"Supplfig16_a.tif","date_updated":"2023-08-03T14:20:56Z","checksum":"663bf013cf1e5019e1e7ddd2d12fa492","success":1},{"file_name":"Supplfig16_b.tif","file_id":"13870","date_updated":"2023-08-03T14:20:56Z","success":1,"checksum":"80aee233dc2a1f26ed8cc323270cf3a9","file_size":113709,"content_type":"image/tiff","date_created":"2023-08-03T14:20:56Z","access_level":"open_access","creator":"jdanzl","relation":"main_file"},{"file_size":113709,"date_updated":"2023-08-03T14:20:56Z","file_id":"13871","file_name":"Supplfig16_c.tif","success":1,"checksum":"3b408e9345df2f16a942ad4ea61739b7","access_level":"open_access","relation":"main_file","creator":"jdanzl","date_created":"2023-08-03T14:20:56Z","content_type":"image/tiff"},{"content_type":"image/tiff","date_created":"2023-08-03T14:25:47Z","access_level":"open_access","creator":"jdanzl","relation":"main_file","file_id":"13872","file_name":"Supplfig17_a_1.tif","date_updated":"2023-08-03T14:25:47Z","success":1,"checksum":"fbf688ef1f907149f92e9e936d02df72","file_size":6003131},{"access_level":"open_access","relation":"main_file","creator":"jdanzl","content_type":"image/tiff","date_created":"2023-08-03T14:25:47Z","file_size":8004085,"date_updated":"2023-08-03T14:25:47Z","file_id":"13873","file_name":"Supplfig17_a_2.tif","checksum":"9a56470f251f14b43903036fab338f76","success":1},{"date_created":"2023-08-03T14:25:47Z","content_type":"image/tiff","creator":"jdanzl","relation":"main_file","access_level":"open_access","success":1,"checksum":"4578c020ba5d0a6ffe2a8a1c22e52c75","file_name":"Supplfig17_a_3.tif","file_id":"13874","date_updated":"2023-08-03T14:25:47Z","file_size":6003123},{"checksum":"a681d32f515da3bff8e803946f1d8b50","success":1,"file_name":"Supplfig17_a_4.tif","file_id":"13875","date_updated":"2023-08-03T14:25:47Z","file_size":6003131,"content_type":"image/tiff","date_created":"2023-08-03T14:25:47Z","creator":"jdanzl","relation":"main_file","access_level":"open_access"},{"date_created":"2023-08-03T14:25:47Z","content_type":"image/tiff","access_level":"open_access","creator":"jdanzl","relation":"main_file","file_name":"Supplfig17_a_5.tif","file_id":"13876","date_updated":"2023-08-03T14:25:47Z","success":1,"checksum":"b89d366c39e25d17dc5d8ceee9145c8b","file_size":6003131},{"relation":"main_file","creator":"jdanzl","access_level":"open_access","date_created":"2023-08-03T14:25:47Z","content_type":"image/tiff","file_size":6003079,"success":1,"checksum":"0b9d60f0aba79525a97c122d972f0b22","date_updated":"2023-08-03T14:25:47Z","file_id":"13877","file_name":"Supplfig17_a_6.tif"},{"access_level":"open_access","relation":"main_file","creator":"jdanzl","date_created":"2023-08-03T14:25:47Z","content_type":"image/tiff","file_size":6003115,"date_updated":"2023-08-03T14:25:47Z","file_name":"Supplfig17_a_7.tif","file_id":"13878","success":1,"checksum":"169aad3cea521cc2a0ce4c3e41473e0c"},{"access_level":"open_access","relation":"main_file","creator":"jdanzl","content_type":"image/tiff","date_created":"2023-08-03T14:25:47Z","file_size":4002129,"date_updated":"2023-08-03T14:25:47Z","file_name":"Supplfig17_a_8.tif","file_id":"13879","checksum":"39a44d77d9047bfa10da8d9c9bd7b391","success":1},{"checksum":"f4ecb2bd44f2cea3d71587670344ac40","success":1,"date_updated":"2023-08-03T14:25:48Z","file_name":"Supplfig17_b.tif","file_id":"13880","file_size":8214335,"content_type":"image/tiff","date_created":"2023-08-03T14:25:48Z","relation":"main_file","creator":"jdanzl","access_level":"open_access"},{"access_level":"open_access","relation":"main_file","creator":"jdanzl","content_type":"image/tiff","date_created":"2023-08-03T14:27:06Z","file_size":7471479,"date_updated":"2023-08-03T14:27:06Z","file_name":"Supplfig18_a.tif","file_id":"13881","success":1,"checksum":"44a20d2621680c90227416bf32b5a566"},{"file_size":290625,"success":1,"checksum":"5a5f7b616785f9213064e8c77f9d38c4","date_updated":"2023-08-03T14:27:06Z","file_id":"13882","file_name":"Supplfig18_b.tif","relation":"main_file","creator":"jdanzl","access_level":"open_access","content_type":"image/tiff","date_created":"2023-08-03T14:27:06Z"},{"content_type":"image/tiff","date_created":"2023-08-03T14:27:07Z","access_level":"open_access","relation":"main_file","creator":"jdanzl","date_updated":"2023-08-03T14:27:07Z","file_name":"Supplfig18_c.tif","file_id":"13883","checksum":"8f621722a636e808a03d85f9597ad1a2","success":1,"file_size":411767},{"checksum":"3c8356f9170fe345e2ef725cd7d1b167","success":1,"file_name":"Supplfig18_d.tif","file_id":"13884","date_updated":"2023-08-03T14:27:07Z","file_size":11117685,"content_type":"image/tiff","date_created":"2023-08-03T14:27:07Z","creator":"jdanzl","relation":"main_file","access_level":"open_access"},{"file_name":"Supplfig18_e_n2v.tif","file_id":"13885","date_updated":"2023-08-03T14:27:10Z","success":1,"checksum":"5c8443e97724b54f359f7355483b890e","file_size":259509773,"content_type":"image/tiff","date_created":"2023-08-03T14:27:10Z","access_level":"open_access","creator":"jdanzl","relation":"main_file"},{"checksum":"413e3105c1bcd2ac2c569fa2b06253f2","success":1,"file_id":"13886","file_name":"Supplfig19_n2v.tif","date_updated":"2023-08-03T14:29:25Z","file_size":1430939360,"content_type":"image/tiff","date_created":"2023-08-03T14:29:25Z","creator":"jdanzl","relation":"main_file","access_level":"open_access"},{"content_type":"image/tiff","date_created":"2023-08-03T14:29:16Z","creator":"jdanzl","relation":"main_file","access_level":"open_access","checksum":"a864dc5b54f469c723e86286d538bb52","success":1,"file_id":"13887","file_name":"Supplfig19.tif","date_updated":"2023-08-03T14:29:16Z","file_size":715524468},{"relation":"main_file","creator":"jdanzl","access_level":"open_access","content_type":"image/tiff","date_created":"2023-08-03T14:32:54Z","file_size":8004743,"checksum":"8a78ce49446d207c0bf31196b788fa93","success":1,"date_updated":"2023-08-03T14:32:54Z","file_name":"Supplfig20_a_left.tif","file_id":"13888"},{"date_created":"2023-08-03T14:32:54Z","content_type":"image/tiff","relation":"main_file","creator":"jdanzl","access_level":"open_access","checksum":"48fa3abfd16a00c7a3757d6452a482ec","success":1,"date_updated":"2023-08-03T14:32:54Z","file_name":"Supplfig20_a_right.tif","file_id":"13889","file_size":5561081},{"file_size":8456797,"checksum":"85d82cd94dd3202f04b5987bc4466573","success":1,"file_id":"13890","file_name":"Supplfig20_b_1.tif","date_updated":"2023-08-03T14:32:54Z","creator":"jdanzl","relation":"main_file","access_level":"open_access","date_created":"2023-08-03T14:32:54Z","content_type":"image/tiff"},{"file_size":8456795,"date_updated":"2023-08-03T14:32:54Z","file_name":"Supplfig20_b_2.tif","file_id":"13891","checksum":"e16f04d5d4d40f6ec33456d0cf02e1eb","success":1,"access_level":"open_access","relation":"main_file","creator":"jdanzl","date_created":"2023-08-03T14:32:54Z","content_type":"image/tiff"},{"date_created":"2023-08-03T14:32:54Z","content_type":"image/tiff","access_level":"open_access","relation":"main_file","creator":"jdanzl","date_updated":"2023-08-03T14:32:54Z","file_id":"13892","file_name":"Supplfig20_b_3.tif","checksum":"ff190edb269c28b25d27bffaeb7d25cf","success":1,"file_size":8456796},{"access_level":"open_access","creator":"jdanzl","relation":"main_file","content_type":"image/tiff","date_created":"2023-08-03T14:32:54Z","file_size":8538887,"file_id":"13893","file_name":"Supplfig20_b_4.tif","date_updated":"2023-08-03T14:32:54Z","checksum":"deb10b81bae62d9e20e681411fb75fcc","success":1},{"file_id":"13894","file_name":"Supplfig20_b_5.tif","date_updated":"2023-08-03T14:32:54Z","success":1,"checksum":"5c64bb94e76030d7a9d8624bac4b0f57","file_size":8538851,"date_created":"2023-08-03T14:32:54Z","content_type":"image/tiff","access_level":"open_access","creator":"jdanzl","relation":"main_file"},{"file_size":11077737,"file_name":"Supplfig20_c_1.tif","file_id":"13895","date_updated":"2023-08-03T14:32:54Z","success":1,"checksum":"d6c20232c4bd36e213b4c456c5009644","access_level":"open_access","creator":"jdanzl","relation":"main_file","content_type":"image/tiff","date_created":"2023-08-03T14:32:54Z"},{"date_created":"2023-08-03T14:32:54Z","content_type":"image/tiff","access_level":"open_access","relation":"main_file","creator":"jdanzl","date_updated":"2023-08-03T14:32:54Z","file_name":"Supplfig20_c_2.tif","file_id":"13896","success":1,"checksum":"49c3396b8960af3f6fd8f6b078971d51","file_size":11077737},{"creator":"jdanzl","relation":"main_file","access_level":"open_access","content_type":"image/tiff","date_created":"2023-08-03T14:32:55Z","file_size":11077737,"success":1,"checksum":"73471528f691fb337839b84c31014da4","file_name":"Supplfig20_c_3.tif","file_id":"13897","date_updated":"2023-08-03T14:32:55Z"},{"date_created":"2023-08-03T14:32:55Z","content_type":"image/tiff","access_level":"open_access","creator":"jdanzl","relation":"main_file","file_id":"13898","file_name":"Supplfig20_c_4.tif","date_updated":"2023-08-03T14:32:55Z","checksum":"47a0fd1a36d7e7907ce18007bdaaa145","success":1,"file_size":11077737},{"checksum":"0c74b07f13fb08a91e61669368f38c9a","success":1,"file_name":"Supplfig20_c_5.tif","file_id":"13899","date_updated":"2023-08-03T14:32:55Z","file_size":11077737,"content_type":"image/tiff","date_created":"2023-08-03T14:32:55Z","creator":"jdanzl","relation":"main_file","access_level":"open_access"},{"file_size":4002133,"file_name":"Supplfig20_d_1.tif","file_id":"13900","date_updated":"2023-08-03T14:32:55Z","checksum":"fe3b76446ec8bd0d5cdba94a128a84b8","success":1,"access_level":"open_access","creator":"jdanzl","relation":"main_file","date_created":"2023-08-03T14:32:55Z","content_type":"image/tiff"},{"file_size":4002133,"date_updated":"2023-08-03T14:32:55Z","file_id":"13901","file_name":"Supplfig20_d_2.tif","success":1,"checksum":"0570bab9a471af3d0d1d8bf9a3cb17e7","access_level":"open_access","relation":"main_file","creator":"jdanzl","date_created":"2023-08-03T14:32:55Z","content_type":"image/tiff"},{"date_created":"2023-08-03T14:32:55Z","content_type":"image/tiff","access_level":"open_access","creator":"jdanzl","relation":"main_file","file_name":"Supplfig20_d_3.tif","file_id":"13902","date_updated":"2023-08-03T14:32:55Z","checksum":"59f330990b5c95f98a768761a009940c","success":1,"file_size":4002199},{"access_level":"open_access","creator":"jdanzl","relation":"main_file","content_type":"image/tiff","date_created":"2023-08-03T14:32:55Z","file_size":4002133,"file_name":"Supplfig20_d_4.tif","file_id":"13903","date_updated":"2023-08-03T14:32:55Z","success":1,"checksum":"f0da06f2a278dff4bbd1aeace11700bf"},{"content_type":"image/tiff","date_created":"2023-08-03T14:32:55Z","access_level":"open_access","creator":"jdanzl","relation":"main_file","file_id":"13904","file_name":"Supplfig20_d_5.tif","date_updated":"2023-08-03T14:32:55Z","checksum":"e61d49dcc0952af3623cc26a78cc6495","success":1,"file_size":4002133},{"date_created":"2023-08-03T14:42:01Z","content_type":"image/tiff","access_level":"open_access","creator":"jdanzl","relation":"main_file","file_id":"13905","file_name":"Supplfig22_b_1.tif","date_updated":"2023-08-03T14:42:01Z","success":1,"checksum":"bcf8294487abaf1a75033f388fba06ec","file_size":12627576},{"access_level":"open_access","relation":"main_file","creator":"jdanzl","content_type":"image/tiff","date_created":"2023-08-03T14:42:01Z","file_size":8543366,"date_updated":"2023-08-03T14:42:01Z","file_name":"Supplfig22_b_2.tif","file_id":"13906","success":1,"checksum":"14097feb4a73e7bb1e1694cef0115cab"},{"creator":"jdanzl","relation":"main_file","access_level":"open_access","date_created":"2023-08-03T14:42:04Z","content_type":"image/tiff","file_size":8394010,"checksum":"7e74b8cff2ada56d47d135a6a9e71e76","success":1,"file_name":"Supplfig22_b_3.tif","file_id":"13907","date_updated":"2023-08-03T14:42:04Z"},{"file_id":"13908","file_name":"Supplfig22_b_4.tif","date_updated":"2023-08-03T15:35:39Z","success":1,"checksum":"f6e6e0f0e3854fedd201ab8ff08a7651","file_size":8682992,"date_created":"2023-08-03T15:35:39Z","content_type":"image/tiff","access_level":"open_access","creator":"jdanzl","relation":"main_file"},{"checksum":"6ddeb84249768b46b9c2072bf85bdc8b","success":1,"date_updated":"2023-08-03T14:42:04Z","file_id":"13909","file_name":"Supplfig22_b_5.tif","file_size":8503466,"content_type":"image/tiff","date_created":"2023-08-03T14:42:04Z","relation":"main_file","creator":"jdanzl","access_level":"open_access"},{"content_type":"image/tiff","date_created":"2023-08-03T14:42:04Z","relation":"main_file","creator":"jdanzl","access_level":"open_access","checksum":"40648b8a4ef375b8352f11a6772ea1a6","success":1,"date_updated":"2023-08-03T14:42:04Z","file_name":"Supplfig22_b_6.tif","file_id":"13910","file_size":8543342},{"success":1,"checksum":"78f601de4d88f6ccb97861eaf4a995f8","date_updated":"2023-08-03T14:42:06Z","file_name":"Supplfig22_b_7.tif","file_id":"13911","file_size":33588990,"content_type":"image/tiff","date_created":"2023-08-03T14:42:06Z","relation":"main_file","creator":"jdanzl","access_level":"open_access"},{"file_size":1453171518,"success":1,"checksum":"2873c488b7c8ad4d111726025086e9ea","date_updated":"2023-08-03T14:42:41Z","file_name":"Supplfig22_c.tif","file_id":"13912","relation":"main_file","creator":"jdanzl","access_level":"open_access","content_type":"image/tiff","date_created":"2023-08-03T14:42:41Z"},{"checksum":"c1d0e5e61ac0d0ddf08704769f80ac78","success":1,"date_updated":"2023-08-03T14:47:43Z","file_name":"Supplfig23_a.tif","file_id":"13913","file_size":1325919782,"content_type":"image/tiff","date_created":"2023-08-03T14:47:43Z","relation":"main_file","creator":"jdanzl","access_level":"open_access"},{"date_updated":"2023-08-03T14:47:25Z","file_id":"13914","file_name":"Supplfig23_b.tif","checksum":"f97632984b6a73e06cc0c8c947cdcc71","success":1,"file_size":31366288,"content_type":"image/tiff","date_created":"2023-08-03T14:47:25Z","access_level":"open_access","relation":"main_file","creator":"jdanzl"},{"content_type":"image/tiff","date_created":"2023-08-03T14:47:26Z","creator":"jdanzl","relation":"main_file","access_level":"open_access","success":1,"checksum":"16f4c17835a79d7c06e2a97b1603baf1","file_id":"13915","file_name":"Supplfig23_c.tif","date_updated":"2023-08-03T14:47:26Z","file_size":31366288},{"file_size":31366428,"checksum":"00f35ca77165642ca9b3bc3608bd04c1","success":1,"file_name":"Supplfig23_d.tif","file_id":"13916","date_updated":"2023-08-03T14:47:27Z","creator":"jdanzl","relation":"main_file","access_level":"open_access","date_created":"2023-08-03T14:47:27Z","content_type":"image/tiff"},{"date_created":"2023-08-03T14:47:27Z","content_type":"image/tiff","creator":"jdanzl","relation":"main_file","access_level":"open_access","success":1,"checksum":"1aff850f47ae8c8f05ca48ff9faa38b1","file_id":"13917","file_name":"Supplfig23_e.tif","date_updated":"2023-08-03T14:47:27Z","file_size":31500832},{"file_size":44179078,"success":1,"checksum":"f644de697d142c83461ed5ad1d72a043","date_updated":"2023-08-03T14:48:38Z","file_name":"Supplfig24_a_i.tif","file_id":"13918","relation":"main_file","creator":"jdanzl","access_level":"open_access","date_created":"2023-08-03T14:48:38Z","content_type":"image/tiff"},{"file_size":44125924,"success":1,"checksum":"eccb84925a6699b396d4b07efcbc7349","date_updated":"2023-08-03T14:48:38Z","file_name":"Supplfig24_a_ii.tif","file_id":"13919","relation":"main_file","creator":"jdanzl","access_level":"open_access","content_type":"image/tiff","date_created":"2023-08-03T14:48:38Z"},{"checksum":"afe7253e70ec79144e59b28c3c66703a","success":1,"file_name":"Supplfig24_a.tif","file_id":"13920","date_updated":"2023-08-03T14:48:54Z","file_size":1061835435,"content_type":"image/tiff","date_created":"2023-08-03T14:48:54Z","creator":"jdanzl","relation":"main_file","access_level":"open_access"},{"file_size":3977824,"checksum":"94a03b022aa84ea6e8515450a481ad82","success":1,"date_updated":"2023-08-03T14:48:39Z","file_name":"Supplfig24_b_iii.tif","file_id":"13921","relation":"main_file","creator":"jdanzl","access_level":"open_access","content_type":"image/tiff","date_created":"2023-08-03T14:48:39Z"},{"date_updated":"2023-08-03T14:48:39Z","file_id":"13922","file_name":"Supplfig24_b_iv.tif","checksum":"166832c173fcda88ec6e35decdf0d197","success":1,"file_size":3977825,"date_created":"2023-08-03T14:48:39Z","content_type":"image/tiff","access_level":"open_access","relation":"main_file","creator":"jdanzl"},{"file_size":37641738,"success":1,"checksum":"53175073b83ab569241ae64ef7f180b3","date_updated":"2023-08-03T14:51:27Z","file_id":"13923","file_name":"Supplfig25_a_1.tif","relation":"main_file","creator":"jdanzl","access_level":"open_access","content_type":"image/tiff","date_created":"2023-08-03T14:51:27Z"},{"creator":"jdanzl","relation":"main_file","access_level":"open_access","content_type":"image/tiff","date_created":"2023-08-03T14:51:26Z","file_size":4932897,"checksum":"70e6a1780daeae6a5bef2c27c996c442","success":1,"file_name":"Supplfig25_a_2.tif","file_id":"13924","date_updated":"2023-08-03T14:51:26Z"},{"relation":"main_file","creator":"jdanzl","access_level":"open_access","content_type":"image/tiff","date_created":"2023-08-03T14:51:31Z","file_size":357433570,"success":1,"checksum":"1748266d7b8a2ae1f6292b9c265c2068","date_updated":"2023-08-03T14:51:31Z","file_id":"13925","file_name":"Supplfig25_b_1.tif"},{"file_size":27734506,"success":1,"checksum":"8490f44160a482ea06d858eb3bc25a11","file_name":"Supplfig25_b_2.tif","file_id":"13926","date_updated":"2023-08-03T14:51:27Z","creator":"jdanzl","relation":"main_file","access_level":"open_access","content_type":"image/tiff","date_created":"2023-08-03T14:51:27Z"},{"date_created":"2023-08-03T14:53:43Z","content_type":"image/tiff","relation":"main_file","creator":"jdanzl","access_level":"open_access","success":1,"checksum":"e5e9c550cc934a7725dc209c79951847","date_updated":"2023-08-03T14:53:43Z","file_id":"13927","file_name":"Suppfig26_h.tif","file_size":35082394},{"access_level":"open_access","relation":"main_file","creator":"jdanzl","content_type":"image/tiff","date_created":"2023-08-03T14:53:42Z","file_size":16676477,"date_updated":"2023-08-03T14:53:42Z","file_name":"Supplfig26_a_1.tif","file_id":"13928","checksum":"39ae411d1e950e78bdc12937fb36f661","success":1},{"date_updated":"2023-08-03T14:53:42Z","file_id":"13929","file_name":"Supplfig26_a_2.tif","checksum":"450f5d0e8091639e27eb7a7991524e88","success":1,"file_size":170493,"date_created":"2023-08-03T14:53:42Z","content_type":"image/tiff","access_level":"open_access","relation":"main_file","creator":"jdanzl"},{"relation":"main_file","creator":"jdanzl","access_level":"open_access","content_type":"image/tiff","date_created":"2023-08-03T14:53:43Z","file_size":11117737,"checksum":"8e5a71801fa1fcb7f679d1af23344662","success":1,"date_updated":"2023-08-03T14:53:43Z","file_name":"Supplfig26_b_1.tif","file_id":"13930"},{"success":1,"checksum":"519fb0326a0f0774b3edc1dafffcdd08","date_updated":"2023-08-03T14:53:43Z","file_id":"13931","file_name":"Supplfig26_b_2.tif","file_size":113753,"content_type":"image/tiff","date_created":"2023-08-03T14:53:43Z","relation":"main_file","creator":"jdanzl","access_level":"open_access"},{"checksum":"d051c7d717eeb6f2ca59d8727ea62200","success":1,"date_updated":"2023-08-03T14:53:52Z","file_id":"13932","file_name":"Supplfig26_c.tif","file_size":495452386,"content_type":"image/tiff","date_created":"2023-08-03T14:53:52Z","relation":"main_file","creator":"jdanzl","access_level":"open_access"},{"success":1,"checksum":"5437b53e708572e2e9ad1432c260a04f","date_updated":"2023-08-03T14:53:46Z","file_name":"Supplfig26_d.tif","file_id":"13933","file_size":132167170,"content_type":"image/tiff","date_created":"2023-08-03T14:53:46Z","relation":"main_file","creator":"jdanzl","access_level":"open_access"},{"checksum":"0baab38829a8587ded5e39f85068124b","success":1,"date_updated":"2023-08-03T14:53:46Z","file_name":"Supplfig26_e.tif","file_id":"13934","file_size":11431214,"content_type":"image/tiff","date_created":"2023-08-03T14:53:46Z","relation":"main_file","creator":"jdanzl","access_level":"open_access"},{"file_size":64005702,"file_name":"Supplfig26_f.tif","file_id":"13935","date_updated":"2023-08-03T14:53:48Z","checksum":"afa57f254c9dd987d90d5e43db3fb9e6","success":1,"access_level":"open_access","creator":"jdanzl","relation":"main_file","date_created":"2023-08-03T14:53:48Z","content_type":"image/tiff"},{"relation":"main_file","creator":"jdanzl","access_level":"open_access","date_created":"2023-08-03T14:53:52Z","content_type":"image/tiff","file_size":246421054,"success":1,"checksum":"c35ba67ab92c410cb4370f91f3dea819","date_updated":"2023-08-03T14:53:52Z","file_id":"13936","file_name":"Supplfig26_g.tif"},{"date_updated":"2023-08-03T14:56:43Z","file_name":"Supplfig27_a.tif","file_id":"13937","checksum":"3fd6186d73cbce1be79cf14a94a7f3bd","success":1,"file_size":166614932,"content_type":"image/tiff","date_created":"2023-08-03T14:56:43Z","access_level":"open_access","relation":"main_file","creator":"jdanzl"},{"content_type":"image/tiff","date_created":"2023-08-03T14:56:42Z","creator":"jdanzl","relation":"main_file","access_level":"open_access","checksum":"d1fc4c88e8e258e4e536a26e196d09b0","success":1,"file_id":"13938","file_name":"Supplfig27_b.tif","date_updated":"2023-08-03T14:56:42Z","file_size":143583446},{"content_type":"image/tiff","date_created":"2023-08-03T14:56:47Z","creator":"jdanzl","relation":"main_file","access_level":"open_access","checksum":"8d6985530e86f38548e89e6380d73771","success":1,"file_name":"Supplfig27_c.tif","file_id":"13939","date_updated":"2023-08-03T14:56:47Z","file_size":172528188},{"date_created":"2023-08-03T14:56:46Z","content_type":"image/tiff","relation":"main_file","creator":"jdanzl","access_level":"open_access","checksum":"d0b1309d2120892ede84e04fdf0dbfbf","success":1,"date_updated":"2023-08-03T14:56:46Z","file_name":"Supplfig27_d.tif","file_id":"13940","file_size":113699256},{"creator":"jdanzl","relation":"main_file","access_level":"open_access","date_created":"2023-08-03T14:56:47Z","content_type":"image/tiff","file_size":88664548,"checksum":"4789b5254d0415ce314fc9e39cc52121","success":1,"file_id":"13941","file_name":"Supplfig27_e.tif","date_updated":"2023-08-03T14:56:47Z"},{"creator":"jdanzl","relation":"main_file","access_level":"open_access","date_created":"2023-08-03T14:56:47Z","content_type":"image/tiff","file_size":2298356,"checksum":"7ff2d06534f062b0f17dab181f6c1f4e","success":1,"file_id":"13942","file_name":"Supplfig27_f.tif","date_updated":"2023-08-03T14:56:47Z"},{"file_id":"13943","file_name":"Supplfig27_g_1.tif","date_updated":"2023-08-03T14:56:47Z","success":1,"checksum":"46de66d457b0def90f753c11927536b7","file_size":499618,"content_type":"image/tiff","date_created":"2023-08-03T14:56:47Z","access_level":"open_access","creator":"jdanzl","relation":"main_file"},{"file_id":"13944","file_name":"Supplfig27_g_2.tif","date_updated":"2023-08-03T14:56:50Z","checksum":"9ef5fba064a73a79dbc74b5e166d08ec","success":1,"file_size":202079026,"content_type":"image/tiff","date_created":"2023-08-03T14:56:50Z","access_level":"open_access","creator":"jdanzl","relation":"main_file"},{"file_size":14639269,"file_id":"13945","file_name":"Supplfig27_g_3.tif","date_updated":"2023-08-03T14:56:48Z","success":1,"checksum":"bf956c2b58d3da2baa869db5206d8d49","access_level":"open_access","creator":"jdanzl","relation":"main_file","content_type":"image/tiff","date_created":"2023-08-03T14:56:48Z"},{"file_size":279467712,"success":1,"checksum":"327dca11f42d5375d7f47f4cbd5b36c0","file_id":"13946","file_name":"model.p","date_updated":"2023-08-03T15:21:01Z","creator":"jdanzl","relation":"main_file","access_level":"open_access","content_type":"application/octet-stream","date_created":"2023-08-03T15:21:01Z"}],"acknowledgement":"We thank Jakob Vorlaufer, Nathalie Agudelo-Dueñas, Wiebke Jahr, Andreas Wartak for microscope maintenance and troubleshooting, Caroline Kreuzinger, Anna Freeman, and Irene Erber for technical assistance and Matthias Tomschik for support with obtaining human samples. We gratefully acknowledge Eder Miguel for setting up webKnossos and Marek Šuplata for computational support and hardware control. We are grateful to Ryuichi Shigemoto and Bernd Bickel for generous support, and Michael Sixt and Scott Boyd (Stanford University) for discussions and critical reading of the manuscript. PSD95-HaloTag mice were kindly provided by Seth Grant (University of Edinburgh). We acknowledge expert support by IST Austria’s scientific computing, imaging and optics, preclinical, and lab support facilities, and by the Library and Miba machine shop.\r\nWe gratefully acknowledge funding by the following sources: \r\nAustrian Science Fund (FWF) grant I3600-B27 (JGD)\r\nAustrian Science Fund (FWF) grant DK W1232 (JGD, JMM)\r\nAustrian Science Fund (FWF) grant Z 312-B27, Wittgenstein award (PJ)\r\nAustrian Science Funds (FWF) projects I4685-B, I6565-B (SYNABS) and DOC 33-B27 (RH)\r\nGesellschaft für Forschungsförderung NÖ (NFB) grant LSC18-022 (JGD)\r\nEuropean Union’s Horizon 2020 research and innovation programme, European Research Council (ERC) grant 715508 – REVERSEAUTISM (GN)\r\nEuropean Union’s Horizon 2020 research and innovation programme, European Research Council (ERC) grant 692692 – GIANTSYN (PJ)\r\nMarie Skłodowska-Curie Actions Fellowship GA no. 665385 under the EU Horizon 2020 program (JMM, JL)\r\nMarie Skłodowska-Curie Actions Individual Fellowship 101026635 under the EU Horizon 2020 program (JFW)","publisher":"Institute of Science and Technology Austria","author":[{"full_name":"Danzl, Johann G","id":"42EFD3B6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8559-3973","first_name":"Johann G","last_name":"Danzl"}],"acknowledged_ssus":[{"_id":"ScienComp"},{"_id":"Bio"},{"_id":"PreCl"},{"_id":"LifeSc"},{"_id":"M-Shop"},{"_id":"E-Lib"}],"related_material":{"link":[{"url":"https://pub.ista.ac.at/group_danzl/data/CATS/","relation":"research_data","description":"Original data for Fig. 5d, Fig. 5d (N2V) and Fig. 5f-i, provided via an external link due to the large size (>10GB) of the datasets. "}],"record":[{"id":"14257","status":"public","relation":"used_in_publication"}]},"month":"08","year":"2023","contributor":[{"id":"443DB6DE-F248-11E8-B48F-1D18A9856A87","first_name":"Julia M","last_name":"Michalska"},{"first_name":"Julia","last_name":"Lyudchik","id":"46E28B80-F248-11E8-B48F-1D18A9856A87"},{"id":"39BDC62C-F248-11E8-B48F-1D18A9856A87","last_name":"Velicky","first_name":"Philipp","orcid":"0000-0002-2340-7431"},{"first_name":"Hana","last_name":"Stefanickova","id":"ee3cb6ca-ec98-11ea-ae11-ff703e2254ed"},{"orcid":"0000-0002-8698-3823","first_name":"Jake","last_name":"Watson","id":"63836096-4690-11EA-BD4E-32803DDC885E"},{"id":"9ac8f577-2357-11eb-997a-e566c5550886","first_name":"Alban","last_name":"Cenameri"},{"orcid":"0000-0003-1216-9105","first_name":"Christoph M","last_name":"Sommer","id":"4DF26D8C-F248-11E8-B48F-1D18A9856A87"},{"id":"4CD6AAC6-F248-11E8-B48F-1D18A9856A87","first_name":"Nicole","orcid":"0000-0002-3183-8207","last_name":"Amberg"},{"first_name":"Alessandro","orcid":"0000-0003-2356-9403","last_name":"Venturino","id":"41CB84B2-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Karl","last_name":"Roessler"},{"last_name":"Czech","first_name":"Thomas"},{"last_name":"Höftberger","first_name":"Romana"},{"last_name":"Siegert","first_name":"Sandra","orcid":"0000-0001-8635-0877","id":"36ACD32E-F248-11E8-B48F-1D18A9856A87"},{"id":"3E57A680-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-7673-7178","first_name":"Gaia","last_name":"Novarino"},{"last_name":"Jonas","orcid":"0000-0001-5001-4804","first_name":"Peter M","id":"353C1B58-F248-11E8-B48F-1D18A9856A87"}],"file_date_updated":"2023-08-04T13:19:47Z","citation":{"chicago":"Danzl, Johann G. “Research Data for the Publication ‘Imaging Brain Tissue Architecture across Millimeter to Nanometer Scales.’” Institute of Science and Technology Austria, 2023. <a href=\"https://doi.org/10.15479/AT:ISTA:13126\">https://doi.org/10.15479/AT:ISTA:13126</a>.","short":"J.G. Danzl, (2023).","mla":"Danzl, Johann G. <i>Research Data for the Publication “Imaging Brain Tissue Architecture across Millimeter to Nanometer Scales.”</i> Institute of Science and Technology Austria, 2023, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:13126\">10.15479/AT:ISTA:13126</a>.","ista":"Danzl JG. 2023. Research data for the publication ‘Imaging brain tissue architecture across millimeter to nanometer scales’, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:13126\">10.15479/AT:ISTA:13126</a>.","ama":"Danzl JG. Research data for the publication “Imaging brain tissue architecture across millimeter to nanometer scales.” 2023. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:13126\">10.15479/AT:ISTA:13126</a>","ieee":"J. G. Danzl, “Research data for the publication ‘Imaging brain tissue architecture across millimeter to nanometer scales.’” Institute of Science and Technology Austria, 2023.","apa":"Danzl, J. G. (2023). Research data for the publication “Imaging brain tissue architecture across millimeter to nanometer scales.” Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:13126\">https://doi.org/10.15479/AT:ISTA:13126</a>"},"ec_funded":1,"type":"research_data","corr_author":"1","oa_version":"Published Version","date_created":"2023-06-07T07:15:12Z","has_accepted_license":"1","status":"public","abstract":[{"lang":"eng","text":"Mapping the complex and dense arrangement of cells and their connectivity in brain tissue demands nanoscale spatial resolution imaging. Super-resolution optical microscopy excels at visualizing specific molecules and individual cells but fails to provide tissue context. Here, we developed Comprehensive Analysis of Tissues across Scales (CATS), a technology to densely map brain tissue architecture from millimeter regional to nanometer synaptic scales in diverse chemically fixed brain preparations, including rodent and human. CATS uses fixation-compatible extracellular labeling and optical imaging, including stimulated emission depletion or expansion microscopy, to comprehensively delineate cellular structures. It enables three-dimensional reconstruction of single synapses and mapping of synaptic connectivity by identification and analysis of putative synaptic cleft regions. Applying CATS to the mouse hippocampal mossy fiber circuitry, we reconstructed and quantified the synaptic input and output structure of identified neurons. We furthermore demonstrate applicability to clinically derived human tissue samples, including formalin-fixed paraffin-embedded routine diagnostic specimens, for visualizing the cellular architecture of brain tissue in health and disease."}],"project":[{"grant_number":"I03600","_id":"265CB4D0-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","name":"Optical control of synaptic function via adhesion molecules"},{"grant_number":"W1232-B24","name":"Molecular Drug Targets","call_identifier":"FWF","_id":"26AA4EF2-B435-11E9-9278-68D0E5697425"},{"grant_number":"Z00312","call_identifier":"FWF","name":"Synaptic communication in neuronal microcircuits","_id":"25C5A090-B435-11E9-9278-68D0E5697425"},{"grant_number":"LS18-022","_id":"23889792-32DE-11EA-91FC-C7463DDC885E","name":"High content imaging to decode human immune cell interactions in health and allergic disease"},{"grant_number":"715508","name":"Probing the Reversibility of Autism Spectrum Disorders by Employing in vivo and in vitro Models","call_identifier":"H2020","_id":"25444568-B435-11E9-9278-68D0E5697425"},{"call_identifier":"H2020","_id":"25B7EB9E-B435-11E9-9278-68D0E5697425","name":"Biophysics and circuit function of a giant cortical glutamatergic synapse","grant_number":"692692"},{"grant_number":"665385","name":"International IST Doctoral Program","call_identifier":"H2020","_id":"2564DBCA-B435-11E9-9278-68D0E5697425"},{"name":"Synaptic computations of the hippocampal CA3 circuitry","call_identifier":"H2020","_id":"fc2be41b-9c52-11eb-aca3-faa90aa144e9","grant_number":"101026635"}],"ddc":["610"],"date_updated":"2026-04-14T08:34:35Z"},{"pmid":1,"page":"1256-1265","author":[{"full_name":"Velicky, Philipp","id":"39BDC62C-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2340-7431","first_name":"Philipp","last_name":"Velicky"},{"first_name":"Eder","orcid":"0000-0001-5665-0430","last_name":"Miguel Villalba","id":"3FB91342-F248-11E8-B48F-1D18A9856A87","full_name":"Miguel Villalba, Eder"},{"last_name":"Michalska","orcid":"0000-0003-3862-1235","first_name":"Julia M","full_name":"Michalska, Julia M","id":"443DB6DE-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Lyudchik","first_name":"Julia","full_name":"Lyudchik, Julia","id":"46E28B80-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Wei","first_name":"Donglai","full_name":"Wei, Donglai"},{"full_name":"Lin, Zudi","first_name":"Zudi","last_name":"Lin"},{"last_name":"Watson","first_name":"Jake","orcid":"0000-0002-8698-3823","id":"63836096-4690-11EA-BD4E-32803DDC885E","full_name":"Watson, Jake"},{"first_name":"Jakob","last_name":"Troidl","full_name":"Troidl, Jakob"},{"full_name":"Beyer, Johanna","first_name":"Johanna","last_name":"Beyer"},{"id":"43DF3136-F248-11E8-B48F-1D18A9856A87","full_name":"Ben Simon, Yoav","first_name":"Yoav","last_name":"Ben Simon"},{"orcid":"0000-0003-1216-9105","first_name":"Christoph M","last_name":"Sommer","full_name":"Sommer, Christoph M","id":"4DF26D8C-F248-11E8-B48F-1D18A9856A87"},{"id":"425C1CE8-F248-11E8-B48F-1D18A9856A87","full_name":"Jahr, Wiebke","first_name":"Wiebke","orcid":"0000-0003-0201-2315","last_name":"Jahr"},{"full_name":"Cenameri, Alban","id":"9ac8f577-2357-11eb-997a-e566c5550886","last_name":"Cenameri","first_name":"Alban"},{"last_name":"Broichhagen","first_name":"Johannes","full_name":"Broichhagen, Johannes"},{"full_name":"Grant, Seth G.N.","last_name":"Grant","first_name":"Seth G.N."},{"id":"353C1B58-F248-11E8-B48F-1D18A9856A87","full_name":"Jonas, Peter M","first_name":"Peter M","orcid":"0000-0001-5001-4804","last_name":"Jonas"},{"id":"3E57A680-F248-11E8-B48F-1D18A9856A87","full_name":"Novarino, Gaia","last_name":"Novarino","first_name":"Gaia","orcid":"0000-0002-7673-7178"},{"first_name":"Hanspeter","last_name":"Pfister","full_name":"Pfister, Hanspeter"},{"last_name":"Bickel","orcid":"0000-0001-6511-9385","first_name":"Bernd","full_name":"Bickel, Bernd","id":"49876194-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Danzl, Johann G","id":"42EFD3B6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8559-3973","first_name":"Johann G","last_name":"Danzl"}],"acknowledged_ssus":[{"_id":"ScienComp"},{"_id":"Bio"},{"_id":"PreCl"},{"_id":"E-Lib"},{"_id":"LifeSc"},{"_id":"M-Shop"}],"volume":20,"related_material":{"link":[{"url":"https://github.com/danzllab/LIONESS","relation":"software"}],"record":[{"relation":"research_data","id":"12817","status":"public"},{"status":"public","id":"14770","relation":"shorter_version"},{"relation":"dissertation_contains","status":"public","id":"18674"},{"relation":"earlier_version","status":"public","id":"11943"}]},"month":"08","year":"2023","publication_status":"published","file_date_updated":"2025-02-26T08:01:57Z","language":[{"iso":"eng"}],"ec_funded":1,"citation":{"apa":"Velicky, P., Miguel Villalba, E., Michalska, J. M., Lyudchik, J., Wei, D., Lin, Z., … Danzl, J. G. (2023). Dense 4D nanoscale reconstruction of living brain tissue. <i>Nature Methods</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41592-023-01936-6\">https://doi.org/10.1038/s41592-023-01936-6</a>","ista":"Velicky P, Miguel Villalba E, Michalska JM, Lyudchik J, Wei D, Lin Z, Watson J, Troidl J, Beyer J, Ben Simon Y, Sommer CM, Jahr W, Cenameri A, Broichhagen J, Grant SGN, Jonas PM, Novarino G, Pfister H, Bickel B, Danzl JG. 2023. Dense 4D nanoscale reconstruction of living brain tissue. Nature Methods. 20, 1256–1265.","ama":"Velicky P, Miguel Villalba E, Michalska JM, et al. Dense 4D nanoscale reconstruction of living brain tissue. <i>Nature Methods</i>. 2023;20:1256-1265. doi:<a href=\"https://doi.org/10.1038/s41592-023-01936-6\">10.1038/s41592-023-01936-6</a>","ieee":"P. Velicky <i>et al.</i>, “Dense 4D nanoscale reconstruction of living brain tissue,” <i>Nature Methods</i>, vol. 20. Springer Nature, pp. 1256–1265, 2023.","mla":"Velicky, Philipp, et al. “Dense 4D Nanoscale Reconstruction of Living Brain Tissue.” <i>Nature Methods</i>, vol. 20, Springer Nature, 2023, pp. 1256–65, doi:<a href=\"https://doi.org/10.1038/s41592-023-01936-6\">10.1038/s41592-023-01936-6</a>.","short":"P. Velicky, E. Miguel Villalba, J.M. Michalska, J. Lyudchik, D. Wei, Z. Lin, J. Watson, J. Troidl, J. Beyer, Y. Ben Simon, C.M. Sommer, W. Jahr, A. Cenameri, J. Broichhagen, S.G.N. Grant, P.M. Jonas, G. Novarino, H. Pfister, B. Bickel, J.G. Danzl, Nature Methods 20 (2023) 1256–1265.","chicago":"Velicky, Philipp, Eder Miguel Villalba, Julia M Michalska, Julia Lyudchik, Donglai Wei, Zudi Lin, Jake Watson, et al. “Dense 4D Nanoscale Reconstruction of Living Brain Tissue.” <i>Nature Methods</i>. Springer Nature, 2023. <a href=\"https://doi.org/10.1038/s41592-023-01936-6\">https://doi.org/10.1038/s41592-023-01936-6</a>."},"article_type":"original","type":"journal_article","corr_author":"1","scopus_import":"1","oa_version":"Published Version","publication":"Nature Methods","date_created":"2023-07-23T22:01:13Z","has_accepted_license":"1","status":"public","external_id":{"pmid":["37429995"],"isi":["001025621500001"]},"abstract":[{"lang":"eng","text":"Three-dimensional (3D) reconstruction of living brain tissue down to an individual synapse level would create opportunities for decoding the dynamics and structure–function relationships of the brain’s complex and dense information processing network; however, this has been hindered by insufficient 3D resolution, inadequate signal-to-noise ratio and prohibitive light burden in optical imaging, whereas electron microscopy is inherently static. Here we solved these challenges by developing an integrated optical/machine-learning technology, LIONESS (live information-optimized nanoscopy enabling saturated segmentation). This leverages optical modifications to stimulated emission depletion microscopy in comprehensively, extracellularly labeled tissue and previous information on sample structure via machine learning to simultaneously achieve isotropic super-resolution, high signal-to-noise ratio and compatibility with living tissue. This allows dense deep-learning-based instance segmentation and 3D reconstruction at a synapse level, incorporating molecular, activity and morphodynamic information. LIONESS opens up avenues for studying the dynamic functional (nano-)architecture of living brain tissue."}],"project":[{"name":"Optical control of synaptic function via adhesion molecules","call_identifier":"FWF","_id":"265CB4D0-B435-11E9-9278-68D0E5697425","grant_number":"I03600"},{"grant_number":"W1232","call_identifier":"FWF","name":"Molecular Drug Targets","_id":"2548AE96-B435-11E9-9278-68D0E5697425"},{"call_identifier":"FWF","_id":"25C5A090-B435-11E9-9278-68D0E5697425","name":"Synaptic communication in neuronal microcircuits","grant_number":"Z00312"},{"grant_number":"LS18-022","name":"High content imaging to decode human immune cell interactions in health and allergic disease","_id":"23889792-32DE-11EA-91FC-C7463DDC885E"},{"grant_number":"665385","call_identifier":"H2020","name":"International IST Doctoral Program","_id":"2564DBCA-B435-11E9-9278-68D0E5697425"},{"call_identifier":"H2020","name":"MATERIALIZABLE: Intelligent fabrication-oriented Computational Design and Modeling","_id":"24F9549A-B435-11E9-9278-68D0E5697425","grant_number":"715767"},{"grant_number":"715508","name":"Probing the Reversibility of Autism Spectrum Disorders by Employing in vivo and in vitro Models","call_identifier":"H2020","_id":"25444568-B435-11E9-9278-68D0E5697425"},{"grant_number":"692692","_id":"25B7EB9E-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"Biophysics and circuit function of a giant cortical glutamatergic synapse"},{"_id":"fc2be41b-9c52-11eb-aca3-faa90aa144e9","call_identifier":"H2020","name":"Synaptic computations of the hippocampal CA3 circuitry","grant_number":"101026635"},{"name":"High-speed 3D-nanoscopy to study the role of adhesion during 3D cell migration","_id":"2668BFA0-B435-11E9-9278-68D0E5697425","grant_number":"LT00057"}],"OA_type":"hybrid","intvolume":"        20","OA_place":"publisher","ddc":["570"],"date_updated":"2026-07-06T12:49:46Z","article_processing_charge":"Yes (in subscription journal)","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"publication_identifier":{"eissn":["1548-7105"],"issn":["1548-7091"]},"day":"01","department":[{"_id":"PeJo"},{"_id":"GaNo"},{"_id":"BeBi"},{"_id":"JoDa"},{"_id":"Bio"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Dense 4D nanoscale reconstruction of living brain tissue","oa":1,"_id":"13267","date_published":"2023-08-01T00:00:00Z","quality_controlled":"1","doi":"10.1038/s41592-023-01936-6","isi":1,"file":[{"content_type":"application/pdf","date_created":"2025-02-26T08:01:57Z","access_level":"open_access","relation":"main_file","creator":"dernst","date_updated":"2025-02-26T08:01:57Z","file_name":"2023_NatureMethods_Velicky.pdf","file_id":"19088","checksum":"a68e845780a82ea36d0d4d3212a87c10","success":1,"file_size":14103039}],"acknowledgement":"We thank J. Vorlaufer, N. Agudelo and A. Wartak for microscope maintenance and troubleshooting, C. Kreuzinger and A. Freeman for technical assistance, M. Šuplata for hardware control support and M. Cunha dos Santos for initial exploration of software. We\r\nthank P. Henderson for advice on deep-learning training and M. Sixt, S. Boyd and T. Weiss for discussions and critical reading of the manuscript. L. Lavis (Janelia Research Campus) generously provided the JF585-HaloTag ligand. We acknowledge expert support by IST\r\nAustria’s scientific computing, imaging and optics, preclinical, library and laboratory support facilities and by the Miba machine shop. We gratefully acknowledge funding by the following sources: Austrian Science Fund (F.W.F.) grant no. I3600-B27 (J.G.D.), grant no. DK W1232\r\n(J.G.D. and J.M.M.) and grant no. Z 312-B27, Wittgenstein award (P.J.); the Gesellschaft für Forschungsförderung NÖ grant no. LSC18-022 (J.G.D.); an ISTA Interdisciplinary project grant (J.G.D. and B.B.); the European Union’s Horizon 2020 research and innovation programme,\r\nMarie-Skłodowska Curie grant 665385 (J.M.M. and J.L.); the European Union’s Horizon 2020 research and innovation programme, European Research Council grant no. 715767, MATERIALIZABLE (B.B.); grant no. 715508, REVERSEAUTISM (G.N.); grant no. 695568, SYNNOVATE (S.G.N.G.); and grant no. 692692, GIANTSYN (P.J.); the Simons\r\nFoundation Autism Research Initiative grant no. 529085 (S.G.N.G.); the Wellcome Trust Technology Development grant no. 202932 (S.G.N.G.); the Marie Skłodowska-Curie Actions Individual Fellowship no. 101026635 under the EU Horizon 2020 program (J.F.W.);\r\nthe Human Frontier Science Program postdoctoral fellowship LT000557/2018 (W.J.); and the National Science Foundation grant no. IIS-1835231 (H.P.) and NCS-FO-2124179 (H.P.).","publisher":"Springer Nature"}]