---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '19718'
abstract:
- lang: eng
  text: The cerebral cortex is arguably the most complex organ in humans. The cortical
    architecture is characterized by a remarkable diversity of neuronal and glial
    cell types that make up its neuronal circuits. Following a precise temporally
    ordered program, radial glia progenitor (RGP) cells generate all cortical excitatory
    projection neurons and glial cell-types. Cortical excitatory projection neurons
    are produced either directly or via intermediate progenitors, through indirect
    neurogenesis. How the extensive cortical cell-type diversity is generated during
    cortex development remains, however, a fundamental open question. How do RGPs
    quantitatively and qualitatively generate all the neocortical neurons? How does
    direct and indirect neurogenesis contribute to the establishment of neuronal and
    lineage heterogeneity? Whether RGPs represent a homogeneous and/or multipotent
    progenitor population, or if RGPs consist of heterogeneous groups is currently
    also not known. In this review, we will summarize the latest findings that contributed
    to a deeper insight into the above key questions.
acknowledgement: We wish to thank all members of the Hippenmeyer laboratory at ISTA
  for exciting discussions on the subject of this review. We apologize to colleagues
  whose work we could not cite and/or discuss in the frame of the available space.
  Work in the Hippenmeyer laboratory on the discussed topic is supported by ISTA institutional
  funds, an EMBO LTF (ALTF 994–2023) to F.P, and FWF SFB F78 to S.H.
article_number: '103046'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Fabrizia
  full_name: Pipicelli, Fabrizia
  id: 649134fd-d012-11ed-8f82-db1e5050f9ba
  last_name: Pipicelli
- first_name: Ana
  full_name: Villalba Requena, Ana
  id: 68cb85a0-39f7-11eb-9559-9aaab4f6a247
  last_name: Villalba Requena
  orcid: 0000-0002-5615-5277
- first_name: Simon
  full_name: Hippenmeyer, Simon
  id: 37B36620-F248-11E8-B48F-1D18A9856A87
  last_name: Hippenmeyer
  orcid: 0000-0003-2279-1061
citation:
  ama: Pipicelli F, Villalba Requena A, Hippenmeyer S. How radial glia progenitor
    lineages generate cell-type diversity in the developing cerebral cortex. <i>Current
    Opinion in Neurobiology</i>. 2025;93. doi:<a href="https://doi.org/10.1016/j.conb.2025.103046">10.1016/j.conb.2025.103046</a>
  apa: Pipicelli, F., Villalba Requena, A., &#38; Hippenmeyer, S. (2025). How radial
    glia progenitor lineages generate cell-type diversity in the developing cerebral
    cortex. <i>Current Opinion in Neurobiology</i>. Elsevier. <a href="https://doi.org/10.1016/j.conb.2025.103046">https://doi.org/10.1016/j.conb.2025.103046</a>
  chicago: Pipicelli, Fabrizia, Ana Villalba Requena, and Simon Hippenmeyer. “How
    Radial Glia Progenitor Lineages Generate Cell-Type Diversity in the Developing
    Cerebral Cortex.” <i>Current Opinion in Neurobiology</i>. Elsevier, 2025. <a href="https://doi.org/10.1016/j.conb.2025.103046">https://doi.org/10.1016/j.conb.2025.103046</a>.
  ieee: F. Pipicelli, A. Villalba Requena, and S. Hippenmeyer, “How radial glia progenitor
    lineages generate cell-type diversity in the developing cerebral cortex,” <i>Current
    Opinion in Neurobiology</i>, vol. 93. Elsevier, 2025.
  ista: Pipicelli F, Villalba Requena A, Hippenmeyer S. 2025. How radial glia progenitor
    lineages generate cell-type diversity in the developing cerebral cortex. Current
    Opinion in Neurobiology. 93, 103046.
  mla: Pipicelli, Fabrizia, et al. “How Radial Glia Progenitor Lineages Generate Cell-Type
    Diversity in the Developing Cerebral Cortex.” <i>Current Opinion in Neurobiology</i>,
    vol. 93, 103046, Elsevier, 2025, doi:<a href="https://doi.org/10.1016/j.conb.2025.103046">10.1016/j.conb.2025.103046</a>.
  short: F. Pipicelli, A. Villalba Requena, S. Hippenmeyer, Current Opinion in Neurobiology
    93 (2025).
corr_author: '1'
date_created: 2025-05-20T10:20:09Z
date_published: 2025-08-01T00:00:00Z
date_updated: 2025-12-30T10:54:14Z
day: '01'
ddc:
- '570'
department:
- _id: SiHi
doi: 10.1016/j.conb.2025.103046
external_id:
  isi:
  - '001496227000001'
  pmid:
  - '40383049'
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has_accepted_license: '1'
intvolume: '        93'
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language:
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month: '08'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 059F6AB4-7A3F-11EA-A408-12923DDC885E
  grant_number: F7805
  name: Stem Cell Modulation in Neural Development and Regeneration/ P05-Molecular
    Mechanisms of Neural Stem Cell Lineage Progression
- _id: 7c084566-9f16-11ee-852c-c88a1dbbf1cf
  grant_number: ALTF 994-2023
  name: Role of cell lineage in generating cell-type diversity in developing neocortex’
publication: Current Opinion in Neurobiology
publication_identifier:
  issn:
  - 0959-4388
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: How radial glia progenitor lineages generate cell-type diversity in the developing
  cerebral cortex
tmp:
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  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
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type: journal_article
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...