[{"publisher":"Oxford University Press","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Causes and consequences of sex-chromosome turnovers in Diptera","year":"2026","DOAJ_listed":"1","acknowledged_ssus":[{"_id":"ScienComp"}],"_id":"21486","date_updated":"2026-07-27T12:00:11Z","publication_identifier":{"eissn":["2056-3744"]},"citation":{"ieee":"L. A. Layana Franco, M. A. Toups, and B. Vicoso, “Causes and consequences of sex-chromosome turnovers in Diptera,” <i>Evolution Letters</i>, vol. 10, no. 3. Oxford University Press, 2026.","short":"L.A. Layana Franco, M.A. Toups, B. Vicoso, Evolution Letters 10 (2026).","mla":"Layana Franco, Lorena Alexandra, et al. “Causes and Consequences of Sex-Chromosome Turnovers in Diptera.” <i>Evolution Letters</i>, vol. 10, no. 3, qrag003, Oxford University Press, 2026, doi:<a href=\"https://doi.org/10.1093/evlett/qrag003\">10.1093/evlett/qrag003</a>.","ista":"Layana Franco LA, Toups MA, Vicoso B. 2026. Causes and consequences of sex-chromosome turnovers in Diptera. Evolution Letters. 10(3), qrag003.","chicago":"Layana Franco, Lorena Alexandra, Melissa A Toups, and Beatriz Vicoso. “Causes and Consequences of Sex-Chromosome Turnovers in Diptera.” <i>Evolution Letters</i>. Oxford University Press, 2026. <a href=\"https://doi.org/10.1093/evlett/qrag003\">https://doi.org/10.1093/evlett/qrag003</a>.","apa":"Layana Franco, L. A., Toups, M. A., &#38; Vicoso, B. (2026). Causes and consequences of sex-chromosome turnovers in Diptera. <i>Evolution Letters</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/evlett/qrag003\">https://doi.org/10.1093/evlett/qrag003</a>","ama":"Layana Franco LA, Toups MA, Vicoso B. Causes and consequences of sex-chromosome turnovers in Diptera. <i>Evolution Letters</i>. 2026;10(3). doi:<a href=\"https://doi.org/10.1093/evlett/qrag003\">10.1093/evlett/qrag003</a>"},"publication_status":"published","article_type":"original","article_number":"qrag003","abstract":[{"text":"Sex-chromosome systems are highly variable across animals, but how they transition from one to another is not well understood. Diptera have undergone multiple sex-chromosome turnovers and expansions while maintaining their general chromosomal content, which makes them an ideal clade to study such transitions. We analyzed more than 100 dipteran whole-genome assemblies and identified 4 new lineages that underwent sex-chromosome turnover (in addition to the 5 previously reported). We find that the majority of turnovers happened in the group Schizophora, which tend to have fewer genes on Muller element F (the chromosome homologous to the ancestral insect X chromosome) than lower dipterans, a factor previously hypothesized to facilitate turnover. Most derived X chromosomes have higher GC content than autosomes, consistent with a high prevalence of male achiasmy in Diptera. In addition, an excess of gene movement out of the X is detected for most of these new X chromosomes, and many of these moved genes have high testis expression in Drosophila, suggesting that out-of-X gene movement contributes to the long-term demasculinization of X chromosomes.","lang":"eng"}],"volume":10,"publication":"Evolution Letters","type":"journal_article","date_created":"2026-03-23T15:05:42Z","file":[{"content_type":"application/pdf","date_created":"2026-07-27T11:59:40Z","date_updated":"2026-07-27T11:59:40Z","creator":"dernst","file_id":"22426","checksum":"7c929e78c369a5e6e064bcf263e955ad","file_name":"2026_EvolutionLetters_Layana.pdf","file_size":1895786,"relation":"main_file","success":1,"access_level":"open_access"}],"ddc":["570"],"tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png"},"month":"06","file_date_updated":"2026-07-27T11:59:40Z","doi":"10.1093/evlett/qrag003","issue":"3","OA_place":"publisher","has_accepted_license":"1","day":"01","language":[{"iso":"eng"}],"article_processing_charge":"Yes","researchdata_availability":"yes","oa_version":"Published Version","department":[{"_id":"BeVi"},{"_id":"GradSch"}],"status":"public","quality_controlled":"1","oa":1,"OA_type":"gold","project":[{"_id":"8ed82125-16d5-11f0-9cad-fbcae312235b","name":"Sex chromosomes in evolution and development","grant_number":"PAT 8748323"}],"date_published":"2026-06-01T00:00:00Z","intvolume":"        10","dataavailabilitystatement":"Scripts, Supplementary Datasets 1–7, and Tables S1, S2, S5 and S6 are also available at https://doi.org/10.15479/AT-ISTA-21116. Pipelines are available at https://git.ista.ac.at/llayanaf/transitions_diptera.","author":[{"orcid":"0000-0002-1253-6297","full_name":"Layana Franco, Lorena Alexandra","last_name":"Layana Franco","first_name":"Lorena Alexandra","id":"02814589-eb8f-11eb-b029-a70074f3f18f"},{"id":"4E099E4E-F248-11E8-B48F-1D18A9856A87","first_name":"Melissa A","orcid":"0000-0002-9752-7380","full_name":"Toups, Melissa A","last_name":"Toups"},{"last_name":"Vicoso","full_name":"Vicoso, Beatriz","orcid":"0000-0002-4579-8306","first_name":"Beatriz","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87"}],"supplementarymaterial":"yes","acknowledgement":"This work was supported by a grant from the Austrian Science Fund (FWF, grant number PAT 8748323) to B.V. We thank the Vicoso group for their feedback on an early version of the manuscript. We are grateful to Kamil Jaron and Julia Gries for helpful discussions and for sharing their unpublished work. Computational resources and support were provided by the Scientific Computing Unit at ISTA.","corr_author":"1"},{"issue":"8","OA_place":"publisher","has_accepted_license":"1","day":"01","article_processing_charge":"Yes (via OA deal)","language":[{"iso":"eng"}],"scopus_import":"1","month":"08","PlanS_conform":"1","file_date_updated":"2025-12-30T09:21:14Z","doi":"10.1016/j.tree.2025.06.010","isi":1,"intvolume":"        40","page":"728-730","author":[{"id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4579-8306","last_name":"Vicoso","full_name":"Vicoso, Beatriz","first_name":"Beatriz"}],"acknowledgement":"I thank the Vicoso group for in-depth discussions of the original article highlighted here. This work was supported by an Austrian Research Fund (FWF) grant to B.V. (PAT 8748323).","corr_author":"1","oa_version":"Published Version","department":[{"_id":"BeVi"}],"quality_controlled":"1","status":"public","oa":1,"OA_type":"hybrid","project":[{"name":"Sex chromosomes in evolution and development","_id":"8ed82125-16d5-11f0-9cad-fbcae312235b","grant_number":"PAT 8748323"}],"external_id":{"isi":["001550437400006"]},"date_published":"2025-08-01T00:00:00Z","_id":"20009","date_updated":"2025-12-30T09:22:29Z","publication_identifier":{"issn":["0169-5347"]},"citation":{"ama":"Vicoso B. Sex chromosome evolution in action in fourspine sticklebacks. <i>Trends in Ecology and Evolution</i>. 2025;40(8):728-730. doi:<a href=\"https://doi.org/10.1016/j.tree.2025.06.010\">10.1016/j.tree.2025.06.010</a>","apa":"Vicoso, B. (2025). Sex chromosome evolution in action in fourspine sticklebacks. <i>Trends in Ecology and Evolution</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.tree.2025.06.010\">https://doi.org/10.1016/j.tree.2025.06.010</a>","chicago":"Vicoso, Beatriz. “Sex Chromosome Evolution in Action in Fourspine Sticklebacks.” <i>Trends in Ecology and Evolution</i>. Elsevier, 2025. <a href=\"https://doi.org/10.1016/j.tree.2025.06.010\">https://doi.org/10.1016/j.tree.2025.06.010</a>.","ista":"Vicoso B. 2025. Sex chromosome evolution in action in fourspine sticklebacks. Trends in Ecology and Evolution. 40(8), 728–730.","mla":"Vicoso, Beatriz. “Sex Chromosome Evolution in Action in Fourspine Sticklebacks.” <i>Trends in Ecology and Evolution</i>, vol. 40, no. 8, Elsevier, 2025, pp. 728–30, doi:<a href=\"https://doi.org/10.1016/j.tree.2025.06.010\">10.1016/j.tree.2025.06.010</a>.","short":"B. Vicoso, Trends in Ecology and Evolution 40 (2025) 728–730.","ieee":"B. Vicoso, “Sex chromosome evolution in action in fourspine sticklebacks,” <i>Trends in Ecology and Evolution</i>, vol. 40, no. 8. Elsevier, pp. 728–730, 2025."},"publisher":"Elsevier","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Sex chromosome evolution in action in fourspine sticklebacks","year":"2025","type":"journal_article","date_created":"2025-07-13T22:01:23Z","ddc":["570"],"file":[{"file_size":699156,"success":1,"relation":"main_file","access_level":"open_access","file_id":"20905","checksum":"0a7c6e8600c878dac7082681e4409b50","file_name":"2025_TrendsEcoloEvolution_Vicoso.pdf","creator":"dernst","content_type":"application/pdf","date_updated":"2025-12-30T09:21:14Z","date_created":"2025-12-30T09:21:14Z"}],"tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png"},"publication_status":"published","article_type":"original","abstract":[{"text":"The suppression of recombination between young X and Y chromosomes is a crucial step in their evolution, but why it occurs is not known. The detailed characterization of the polymorphic sex chromosomes of the fourspine stickleback by Liu et al. promises to shed new light on this longstanding question.","lang":"eng"}],"volume":40,"publication":"Trends in Ecology and Evolution"},{"publication":"Current Opinion in Insect Science","volume":72,"abstract":[{"text":"Sex chromosomes have evolved many times throughout the tree of life, and understanding what has shaped their unusual morphological, sequence, and regulatory features has been a long-standing goal. Most early insights into insect sex chromosome biology came from a few model species, such as the fruit fly Drosophila melanogaster, which limited broad-scale evolutionary inferences. More recently, extensive comparative genomics studies have uncovered several unexpected patterns, which we highlight in this review. First, we describe the conservation of the ancestral X chromosome over 450 million years but also its recurrent turnover (i.e. its reversal to an autosome when a new X chromosome arose) in at least one order. We then summarize classical and more recent findings on how insects modulate the expression of X-linked genes following the degradation of the Y chromosome and how the diverse mechanisms of dosage compensation identified may elucidate important principles of sex chromosome regulatory evolution.","lang":"eng"}],"publication_status":"published","article_type":"review","article_number":"101411","ddc":["570"],"file":[{"content_type":"application/pdf","date_created":"2025-12-30T13:14:20Z","date_updated":"2025-12-30T13:14:20Z","creator":"dernst","file_id":"20917","checksum":"262640abc34277686b56eb60102976f6","file_name":"2025_CurrOpinionInsectScience_Toups.pdf","file_size":897079,"success":1,"relation":"main_file","access_level":"open_access"}],"tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png"},"date_created":"2025-08-17T22:01:35Z","type":"journal_article","year":"2025","publisher":"Elsevier","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Insect sex chromosome evolution: Conservation, turnover, and mechanisms of dosage compensation","citation":{"ama":"Toups MA, Vicoso B. Insect sex chromosome evolution: Conservation, turnover, and mechanisms of dosage compensation. <i>Current Opinion in Insect Science</i>. 2025;72. doi:<a href=\"https://doi.org/10.1016/j.cois.2025.101411\">10.1016/j.cois.2025.101411</a>","mla":"Toups, Melissa A., and Beatriz Vicoso. “Insect Sex Chromosome Evolution: Conservation, Turnover, and Mechanisms of Dosage Compensation.” <i>Current Opinion in Insect Science</i>, vol. 72, 101411, Elsevier, 2025, doi:<a href=\"https://doi.org/10.1016/j.cois.2025.101411\">10.1016/j.cois.2025.101411</a>.","ista":"Toups MA, Vicoso B. 2025. Insect sex chromosome evolution: Conservation, turnover, and mechanisms of dosage compensation. Current Opinion in Insect Science. 72, 101411.","ieee":"M. A. Toups and B. Vicoso, “Insect sex chromosome evolution: Conservation, turnover, and mechanisms of dosage compensation,” <i>Current Opinion in Insect Science</i>, vol. 72. Elsevier, 2025.","short":"M.A. Toups, B. Vicoso, Current Opinion in Insect Science 72 (2025).","apa":"Toups, M. A., &#38; Vicoso, B. (2025). Insect sex chromosome evolution: Conservation, turnover, and mechanisms of dosage compensation. <i>Current Opinion in Insect Science</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cois.2025.101411\">https://doi.org/10.1016/j.cois.2025.101411</a>","chicago":"Toups, Melissa A, and Beatriz Vicoso. “Insect Sex Chromosome Evolution: Conservation, Turnover, and Mechanisms of Dosage Compensation.” <i>Current Opinion in Insect Science</i>. Elsevier, 2025. <a href=\"https://doi.org/10.1016/j.cois.2025.101411\">https://doi.org/10.1016/j.cois.2025.101411</a>."},"publication_identifier":{"eissn":["2214-5753"],"issn":["2214-5745"]},"date_updated":"2025-12-30T13:14:38Z","_id":"20182","project":[{"name":"Sex chromosomes in evolution and development","_id":"8ed82125-16d5-11f0-9cad-fbcae312235b","grant_number":"PAT 8748323"}],"external_id":{"isi":["001582424100001"]},"date_published":"2025-12-01T00:00:00Z","oa":1,"OA_type":"hybrid","department":[{"_id":"BeVi"}],"oa_version":"Published Version","quality_controlled":"1","status":"public","author":[{"first_name":"Melissa A","orcid":"0000-0002-9752-7380","last_name":"Toups","full_name":"Toups, Melissa A","id":"4E099E4E-F248-11E8-B48F-1D18A9856A87"},{"id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","first_name":"Beatriz","last_name":"Vicoso","full_name":"Vicoso, Beatriz","orcid":"0000-0002-4579-8306"}],"acknowledgement":"This work was supported by an Austrian Research Fund (FWF) grant to B.V. (PAT 8748323) and by the Louisiana Board of Regents Research Competitiveness Subprogram (LEQSF(2025-28)-RD-A-20) to MAT.","corr_author":"1","isi":1,"intvolume":"        72","doi":"10.1016/j.cois.2025.101411","PlanS_conform":"1","file_date_updated":"2025-12-30T13:14:20Z","month":"12","article_processing_charge":"Yes (via OA deal)","language":[{"iso":"eng"}],"scopus_import":"1","day":"01","has_accepted_license":"1","OA_place":"publisher"},{"page":"114","author":[{"first_name":"Vincent K","last_name":"Bett","full_name":"Bett, Vincent K","id":"57854184-AAE0-11E9-8D04-98D6E5697425"}],"acknowledgement":"This work was supported by the Austrian Science Fund (FWF) through grants PAT8748323\r\nand SFB F88-10 awarded to Professor Beatriz Vicoso.","corr_author":"1","alternative_title":["ISTA Thesis"],"oa":1,"project":[{"grant_number":"PAT 8748323","name":"Sex chromosomes in evolution and development","_id":"8ed82125-16d5-11f0-9cad-fbcae312235b"},{"name":"The highjacking of meiosis for asexual reproduction","_id":"34ae1506-11ca-11ed-8bc3-c14f4c474396","grant_number":"F8810"}],"date_published":"2025-10-10T00:00:00Z","oa_version":"Published Version","department":[{"_id":"GradSch"},{"_id":"BeVi"}],"status":"public","day":"10","language":[{"iso":"eng"}],"article_processing_charge":"No","OA_place":"publisher","has_accepted_license":"1","doi":"10.15479/AT-ISTA-20449","month":"10","file_date_updated":"2026-06-01T22:30:04Z","file":[{"content_type":"application/pdf","date_created":"2025-10-20T13:32:29Z","date_updated":"2026-06-01T22:30:04Z","creator":"vbett","embargo":"2026-06-01","file_id":"20507","checksum":"26905c22bca417198a733d792d8ce422","file_name":"2025_Bett_Vincent_Thesis.pdf","file_size":18507283,"relation":"main_file","access_level":"open_access"},{"file_id":"20508","file_name":"2025_Bett_Vincent_Thesis.docx","checksum":"6a09a8d126d3628bfd8a35202735f267","relation":"source_file","file_size":17163921,"access_level":"closed","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","date_created":"2025-10-20T13:35:34Z","date_updated":"2026-06-01T22:30:04Z","embargo_to":"open_access","creator":"vbett"}],"ddc":["576"],"tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png"},"related_material":{"record":[{"status":"public","relation":"part_of_dissertation","id":"19735"},{"status":"public","relation":"part_of_dissertation","id":"15009"}]},"type":"dissertation","date_created":"2025-10-11T08:18:51Z","degree_awarded":"PhD","publication_status":"published","abstract":[{"text":"Males and females of many  species differ in morphology, physiology, and behavior. In taxa\r\nwith genetic sex determination, sexual differentiation arises largely from sex-biased gene\r\nexpression, which varies across tissues, developmental stages, and lineages. Increasing\r\nevidence highlights chromatin configuration, which can exist in open or closed states, and can\r\nbe shaped by sex-determination path ways, as a key regulatory layer of this dimorphism.\r\nDegeneration of the Y or W chromosome further contributes to sex -specific differences by\r\naltering gene copy numbers relative to autosomes in heterogametic sex. To mitigate these\r\nimbalances, many eukaryotes have independently evolved dosage compensation mechanisms,\r\noften mediated through chromatin -level regulation. In this thesis, we investigate the\r\nevolutionary dynamics of sex chromosome differentiation in two species, Artemia franciscana\r\nand Cameraria  ohridella , with a particular focus on the extent of dosage compensation\r\nfollowing gene loss in the heterogametic sex and the potential chromatin-based mechanisms\r\nunderlying this process. We further characterize sex -biased gene expression and its regulation\r\nthrough histone modifications. Our analyses also reveal that the A. franciscana genome is\r\nhighly repetitive, with many genes containing intronic transposable elements. We find that\r\nenrichment of histonemo difications associated with constitutive heterochromatin, positively\r\ncorrelates with variation in gene expression levels. Collectively, these findings underscore role\r\nof chromatin regulation in shaping the evolution of sex chromosomes and sexual\r\ndifferentiation. ","lang":"eng"}],"publication_identifier":{"issn":["2663-337X"]},"citation":{"chicago":"Bett, Vincent K. “Evolution and Regulation of the Z Chromosome.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20449\">https://doi.org/10.15479/AT-ISTA-20449</a>.","apa":"Bett, V. K. (2025). <i>Evolution and regulation of the Z chromosome</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20449\">https://doi.org/10.15479/AT-ISTA-20449</a>","ieee":"V. K. Bett, “Evolution and regulation of the Z chromosome,” Institute of Science and Technology Austria, 2025.","short":"V.K. Bett, Evolution and Regulation of the Z Chromosome, Institute of Science and Technology Austria, 2025.","mla":"Bett, Vincent K. <i>Evolution and Regulation of the Z Chromosome</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20449\">10.15479/AT-ISTA-20449</a>.","ista":"Bett VK. 2025. Evolution and regulation of the Z chromosome. Institute of Science and Technology Austria.","ama":"Bett VK. Evolution and regulation of the Z chromosome. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20449\">10.15479/AT-ISTA-20449</a>"},"_id":"20449","acknowledged_ssus":[{"_id":"ScienComp"}],"date_updated":"2026-06-12T08:32:16Z","supervisor":[{"id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4579-8306","full_name":"Vicoso, Beatriz","last_name":"Vicoso","first_name":"Beatriz"}],"year":"2025","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","publisher":"Institute of Science and Technology Austria","title":"Evolution and regulation of the Z chromosome"},{"author":[{"id":"57854184-AAE0-11E9-8D04-98D6E5697425","first_name":"Vincent K","full_name":"Bett, Vincent K","last_name":"Bett"},{"id":"2b681148-eed5-11eb-b81b-ae229e8620f8","last_name":"Trejo Arellano","full_name":"Trejo Arellano, Minerva S","orcid":"0000-0002-1982-3475","first_name":"Minerva S"},{"id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4579-8306","last_name":"Vicoso","full_name":"Vicoso, Beatriz","first_name":"Beatriz"}],"acknowledgement":"We thank the Vicoso lab for their help in maintaining Artemia and for their valuable feedback and suggestions. We thank Marwan Elkrewi for his useful technical advice and discussions. We are also grateful to the Scientific Unit at ISTA Austria for computational resources and assistance. This work was supported by Austrian science fund (FWF) grants PAT8748323 and SFB F88-10 (as part of the SFB Meiosis consortium https://sfbmeiosis.org) to BV and Swedish Research Council (Vetenskapsrådet, grant number 2020-06424) to MSTA.","corr_author":"1","isi":1,"intvolume":"        42","external_id":{"isi":["001483460200001"],"pmid":["40202086"]},"project":[{"grant_number":"PAT 8748323","name":"Sex chromosomes in evolution and development","_id":"8ed82125-16d5-11f0-9cad-fbcae312235b"},{"grant_number":"F8810","_id":"34ae1506-11ca-11ed-8bc3-c14f4c474396","name":"The highjacking of meiosis for asexual reproduction"}],"date_published":"2025-05-01T00:00:00Z","OA_type":"gold","oa":1,"oa_version":"Published Version","department":[{"_id":"BeVi"},{"_id":"DaZi"}],"quality_controlled":"1","status":"public","article_processing_charge":"Yes","language":[{"iso":"eng"}],"scopus_import":"1","day":"01","has_accepted_license":"1","issue":"5","OA_place":"publisher","doi":"10.1093/molbev/msaf085","file_date_updated":"2025-05-28T09:34:36Z","month":"05","ddc":["570"],"file":[{"creator":"dernst","date_updated":"2025-05-28T09:34:36Z","date_created":"2025-05-28T09:34:36Z","content_type":"application/pdf","access_level":"open_access","success":1,"relation":"main_file","file_size":1282772,"file_name":"2025_MBE_Bett.pdf","checksum":"6c14b03f94b4aadf8869be2c4366d077","file_id":"19756"}],"related_material":{"record":[{"status":"public","relation":"dissertation_contains","id":"20449"},{"id":"20444","relation":"dissertation_contains","status":"deleted"}],"link":[{"url":"https://github.com/vkb25/Chromatin-landscape-in-Artemia-franciscana.git","relation":"software"}]},"tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png"},"date_created":"2025-05-25T22:16:56Z","type":"journal_article","publication":"Molecular Biology and Evolution","volume":42,"abstract":[{"lang":"eng","text":"The males and females of the brine shrimp Artemia franciscana are highly dimorphic, and this dimorphism is associated with substantial sex-biased gene expression in heads and gonads. How these sex-specific patterns of expression are regulated at the molecular level is unknown. A. franciscana also has differentiated ZW sex chromosomes, with complete dosage compensation, but the molecular mechanism through which compensation is achieved is unknown. Here, we conducted CUT&TAG assays targeting 7 post-translational histone modifications (H3K27me3, H3K9me2, H3K9me3, H3K36me3, H3K27ac, H3K4me3, and H4K16ac) in heads and gonads of A. franciscana, allowing us to divide the genome into 12 chromatin states. We further defined functional chromatin signatures for all genes, which were correlated with transcript level abundances. Differences in the occupancy of the profiled epigenetic marks between sexes were associated with differential gene expression between males and females. Finally, we found a significant enrichment of the permissive H4K16ac histone mark in the Z-specific region in both tissues of females but not males, supporting the role of this histone mark in mediating dosage compensation of the Z chromosome."}],"article_type":"original","publication_status":"published","article_number":"msaf085","citation":{"ama":"Bett VK, Trejo Arellano MS, Vicoso B. Chromatin landscape is associated with sex-biased expression and Drosophila-like dosage compensation of the Z chromosome in Artemia franciscana. <i>Molecular Biology and Evolution</i>. 2025;42(5). doi:<a href=\"https://doi.org/10.1093/molbev/msaf085\">10.1093/molbev/msaf085</a>","chicago":"Bett, Vincent K, Minerva S Trejo Arellano, and Beatriz Vicoso. “Chromatin Landscape Is Associated with Sex-Biased Expression and Drosophila-like Dosage Compensation of the Z Chromosome in Artemia Franciscana.” <i>Molecular Biology and Evolution</i>. Oxford University Press, 2025. <a href=\"https://doi.org/10.1093/molbev/msaf085\">https://doi.org/10.1093/molbev/msaf085</a>.","apa":"Bett, V. K., Trejo Arellano, M. S., &#38; Vicoso, B. (2025). Chromatin landscape is associated with sex-biased expression and Drosophila-like dosage compensation of the Z chromosome in Artemia franciscana. <i>Molecular Biology and Evolution</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/molbev/msaf085\">https://doi.org/10.1093/molbev/msaf085</a>","short":"V.K. Bett, M.S. Trejo Arellano, B. Vicoso, Molecular Biology and Evolution 42 (2025).","ieee":"V. K. Bett, M. S. Trejo Arellano, and B. Vicoso, “Chromatin landscape is associated with sex-biased expression and Drosophila-like dosage compensation of the Z chromosome in Artemia franciscana,” <i>Molecular Biology and Evolution</i>, vol. 42, no. 5. Oxford University Press, 2025.","mla":"Bett, Vincent K., et al. “Chromatin Landscape Is Associated with Sex-Biased Expression and Drosophila-like Dosage Compensation of the Z Chromosome in Artemia Franciscana.” <i>Molecular Biology and Evolution</i>, vol. 42, no. 5, msaf085, Oxford University Press, 2025, doi:<a href=\"https://doi.org/10.1093/molbev/msaf085\">10.1093/molbev/msaf085</a>.","ista":"Bett VK, Trejo Arellano MS, Vicoso B. 2025. Chromatin landscape is associated with sex-biased expression and Drosophila-like dosage compensation of the Z chromosome in Artemia franciscana. Molecular Biology and Evolution. 42(5), msaf085."},"publication_identifier":{"issn":["0737-4038"],"eissn":["1537-1719"]},"pmid":1,"date_updated":"2026-08-25T22:30:44Z","_id":"19735","acknowledged_ssus":[{"_id":"ScienComp"}],"DOAJ_listed":"1","year":"2025","publisher":"Oxford University Press","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","title":"Chromatin landscape is associated with sex-biased expression and Drosophila-like dosage compensation of the Z chromosome in Artemia franciscana"}]