---
OA_place: repository
OA_type: green
_id: '21994'
abstract:
- lang: eng
text: Adaptive plant development is orchestrated, among others, by directional,
intercellular transport of the phytohormone auxin. Self-organizing development,
such as flexible vasculature formation, depends on so-called auxin canalization,
manifested by the gradual formation of auxin transport channels through feedback
between auxin signalling and transport. Herein, we identify MAKR6 as an important,
novel component in this feedback. MAKR6 expression accumulates strongly in vascular
cells and is tightly regulated by auxin via the Aux/IAA-ARF-WRKY23 transcriptional
network. MAKR6 is required for auxin canalization-dependent processes, including
leaf venation, vasculature regeneration, and de novo auxin channel formation from
local auxin sources. Mechanistically, MAKR6 interacts with the PIN1 auxin transporter,
modulating its trafficking and polarization. MAKR6 also associates with and integrates
two key receptor-like kinase complexes involved in canalization, TMK1/4 and the
CAMEL-CANAR. Together, our study establishes MAKR6 as a multifaceted regulator
that couples transcriptional auxin signalling to PIN1 repolarization and coordinates
multiple RLK-mediated signalling pathways during canalization. This provides mechanistic
insights into auxin canalization and exemplifies a framework for exploring similar
regulatory nodes in other developmental contexts.
acknowledgement: 'We would like to thank Dr. Yvon Jaillais (ENS, Lyon) for sharing
MAKR2 materials. This research was supported by the Scientific Service Units (SSU)
of ISTA through resources provided by the Imaging & Optics Facility (IOF) and the
Lab Support Facility (LSF). The research in the Friml group leading to these results
was funded by the European Research Council (ERC): 101142681 CYNIPS; and the Austrian
Science Fund (FWF): I 6123-B and P 37051-B. Ewa Mazur was supported by the National
Science Centre (NCN), Poland, under the OPUS call in the WEAVE programme: 2021/43/I/NZ1/01835.'
article_processing_charge: No
author:
- first_name: Zengxiang
full_name: Ge, Zengxiang
id: f43371a3-09ff-11eb-8013-bd0c6a2f6de8
last_name: Ge
orcid: 0000-0001-9381-3577
- first_name: Lilla
full_name: Koczka, Lilla
last_name: Koczka
- first_name: Ewa
full_name: Mazur, Ewa
last_name: Mazur
- first_name: Gergely
full_name: Molnar, Gergely
id: 34F1AF46-F248-11E8-B48F-1D18A9856A87
last_name: Molnar
- first_name: Dmitrii
full_name: Vladimirtsev, Dmitrii
id: 60466724-5355-11ee-ae5a-fa55e8f99c3d
last_name: Vladimirtsev
- first_name: Nada
full_name: Kassem, Nada
last_name: Kassem
- first_name: Sara
full_name: Ait Ikene, Sara
id: 6a0bb896-6bad-11f1-9bef-906e9eb76034
last_name: Ait Ikene
- first_name: Lukas
full_name: Fiedler, Lukas
id: 7c417475-8972-11ed-ae7b-8b674ca26986
last_name: Fiedler
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Ge Z, Koczka L, Mazur E, et al. MAKR6 integrates TMK and CAMEL/CANAR signalling
for auxin canalization in Arabidopsis. bioRxiv. doi:10.1101/2025.10.07.680881
apa: Ge, Z., Koczka, L., Mazur, E., Molnar, G., Vladimirtsev, D., Kassem, N., …
Friml, J. (n.d.). MAKR6 integrates TMK and CAMEL/CANAR signalling for auxin canalization
in Arabidopsis. bioRxiv. https://doi.org/10.1101/2025.10.07.680881
chicago: Ge, Zengxiang, Lilla Koczka, Ewa Mazur, Gergely Molnar, Dmitrii Vladimirtsev,
Nada Kassem, Sara Ait Ikene, Lukas Fiedler, and Jiří Friml. “MAKR6 Integrates
TMK and CAMEL/CANAR Signalling for Auxin Canalization in Arabidopsis.” BioRxiv,
n.d. https://doi.org/10.1101/2025.10.07.680881.
ieee: Z. Ge et al., “MAKR6 integrates TMK and CAMEL/CANAR signalling for
auxin canalization in Arabidopsis,” bioRxiv. .
ista: Ge Z, Koczka L, Mazur E, Molnar G, Vladimirtsev D, Kassem N, Ait Ikene S,
Fiedler L, Friml J. MAKR6 integrates TMK and CAMEL/CANAR signalling for auxin
canalization in Arabidopsis. bioRxiv, 10.1101/2025.10.07.680881.
mla: Ge, Zengxiang, et al. “MAKR6 Integrates TMK and CAMEL/CANAR Signalling for
Auxin Canalization in Arabidopsis.” BioRxiv, doi:10.1101/2025.10.07.680881.
short: Z. Ge, L. Koczka, E. Mazur, G. Molnar, D. Vladimirtsev, N. Kassem, S. Ait
Ikene, L. Fiedler, J. Friml, BioRxiv (n.d.).
corr_author: '1'
date_created: 2026-06-13T16:57:07Z
date_published: 2026-05-30T00:00:00Z
date_updated: 2026-06-19T07:14:01Z
day: '30'
ddc:
- '580'
department:
- _id: GradSch
- _id: JiFr
doi: 10.1101/2025.10.07.680881
fulldoi: https://doi.org/10.1101/2025.10.07.680881
has_accepted_license: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/2025.10.07.680881
month: '05'
oa: 1
oa_version: Preprint
project:
- _id: 8f347782-16d5-11f0-9cad-8c19706ee739
grant_number: '101142681'
name: Cyclic nucleotides as second messengers in plants
- _id: bd76d395-d553-11ed-ba76-f678c14f9033
grant_number: I06123
name: Peptide receptors for auxin canalization in Arabidopsis
- _id: 7bcece63-9f16-11ee-852c-ae94e099eeb6
grant_number: P37051
name: Guanylate cyclase activity of TIR1/AFBs auxin receptors
publication: bioRxiv
publication_status: submitted
scopus_import: '1'
status: public
title: MAKR6 integrates TMK and CAMEL/CANAR signalling for auxin canalization in Arabidopsis
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '22301'
abstract:
- lang: eng
text: Auxin, primarily indole-3-acetic acid (IAA), is a central regulator of growth
and development in land plants, but its physiological role in chlorophyte algae
remains unclear. Here, we show that exogenous IAA modulates growth in Chlorella
sorokiniana, Chlorella variabilis, and Chlamydomonas reinhardtii in a concentration-dependent
manner. Low IAA concentrations promoted growth by accelerating the onset of cell
division without affecting cell size, whereas higher concentrations inhibited
proliferation. Radiotracer assays showed that all three species take up and release
IAA across the plasma membrane through a combination of passive diffusion and
energy-dependent, saturable processes. Competition by excess unlabeled natural
and synthetic auxins further supported the presence of carrier-mediated transport
with broad substrate recognition. Phylogenetic analyses identified potential PIN-like
auxin exporters in chlorophytes and other non-plant eukaryotes, and structural
modeling supported conservation of the overall PIN fold and predicted auxin-binding
residues. However, functional assays in Xenopus laevis oocytes, tobacco BY-2 cultured
cells, and Arabidopsis thaliana did not support a role for these proteins in directional
auxin export. Instead, non-plant PIN homologs localized predominantly to the endoplasmic
reticulum and showed limited or no transport activity in heterologous systems.
Together, these findings indicate that auxin responsiveness and basic cellular
auxin transport predate canonical PIN-mediated directional auxin export, which
appears to be a later innovation of the streptophyte lineage.
acknowledged_ssus:
- _id: Bio
- _id: NanoFab
acknowledgement: Research in the Friml group was supported by the European Research
Council (ERC) under grant agreement No. 101142681 (CYNIPS), and by the Austrian
Science Fund (FWF) through projects I 6123-B and P 37051-B. A DOC Fellowship from
the Austrian Academy of Sciences (ÖAW; PR.C0102.1.F.1023.A.2) provided additional
support. Work was partly supported by the Deutsche Forschungsgemeinschaft (DFG,
German Research Foundation) under grant HA 3468/8-1. We thank the Imaging and Optics
Facility (IOF) at the Institute of Science and Technology Austria (ISTA) for support
with confocal imaging, and the Nanofabrication Facility at ISTA for assistance with
microfluidic device fabrication. We also acknowledge the microscopy service of IFIEB
CAS, supported by MEYS CR (LM2023050 Czech-BioImaging). Open Access funding provided
by Institute of Science and Technology Austria.
article_number: jipb.70309
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Adrijana
full_name: Smoljan, Adrijana
id: cced8a85-223e-11ed-af04-b0596c55053b
last_name: Smoljan
- first_name: Sarah
full_name: Koutnik‐Abele, Sarah
last_name: Koutnik‐Abele
- first_name: Dmitrii
full_name: Vladimirtsev, Dmitrii
id: 60466724-5355-11ee-ae5a-fa55e8f99c3d
last_name: Vladimirtsev
- first_name: Petr
full_name: Klíma, Petr
last_name: Klíma
- first_name: Anita
full_name: Bírošíková, Anita
last_name: Bírošíková
- first_name: Yuzhou
full_name: Zhang, Yuzhou
id: 3B6137F2-F248-11E8-B48F-1D18A9856A87
last_name: Zhang
orcid: 0000-0003-2627-6956
- first_name: Jack
full_name: Merrin, Jack
id: 4515C308-F248-11E8-B48F-1D18A9856A87
last_name: Merrin
orcid: 0000-0001-5145-4609
- first_name: Maximilian
full_name: Schuster, Maximilian
id: 37e65def-d415-11eb-ae59-a7b67be103db
last_name: Schuster
- first_name: Katarina
full_name: Kurtović, Katarina
last_name: Kurtović
- first_name: Ulrich Z.
full_name: Hammes, Ulrich Z.
last_name: Hammes
- first_name: Jan
full_name: Petrášek, Jan
last_name: Petrášek
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Smoljan A, Koutnik‐Abele S, Vladimirtsev D, et al. Auxin response and PIN‐mediated
transport in chlorophyte algae. Journal of Integrative Plant Biology. 2026.
doi:10.1111/jipb.70309
apa: Smoljan, A., Koutnik‐Abele, S., Vladimirtsev, D., Klíma, P., Bírošíková, A.,
Zhang, Y., … Friml, J. (2026). Auxin response and PIN‐mediated transport in chlorophyte
algae. Journal of Integrative Plant Biology. Wiley. https://doi.org/10.1111/jipb.70309
chicago: Smoljan, Adrijana, Sarah Koutnik‐Abele, Dmitrii Vladimirtsev, Petr Klíma,
Anita Bírošíková, Yuzhou Zhang, Jack Merrin, et al. “Auxin Response and PIN‐mediated
Transport in Chlorophyte Algae.” Journal of Integrative Plant Biology.
Wiley, 2026. https://doi.org/10.1111/jipb.70309.
ieee: A. Smoljan et al., “Auxin response and PIN‐mediated transport in chlorophyte
algae,” Journal of Integrative Plant Biology. Wiley, 2026.
ista: Smoljan A, Koutnik‐Abele S, Vladimirtsev D, Klíma P, Bírošíková A, Zhang Y,
Merrin J, Schuster M, Kurtović K, Hammes UZ, Petrášek J, Friml J. 2026. Auxin
response and PIN‐mediated transport in chlorophyte algae. Journal of Integrative
Plant Biology., jipb. 70309.
mla: Smoljan, Adrijana, et al. “Auxin Response and PIN‐mediated Transport in Chlorophyte
Algae.” Journal of Integrative Plant Biology, jipb. 70309, Wiley, 2026,
doi:10.1111/jipb.70309.
short: A. Smoljan, S. Koutnik‐Abele, D. Vladimirtsev, P. Klíma, A. Bírošíková, Y.
Zhang, J. Merrin, M. Schuster, K. Kurtović, U.Z. Hammes, J. Petrášek, J. Friml,
Journal of Integrative Plant Biology (2026).
corr_author: '1'
das_tickbox: '0'
date_created: 2026-07-13T10:44:55Z
date_published: 2026-06-10T00:00:00Z
date_updated: 2026-07-13T14:26:31Z
day: '10'
ddc:
- '580'
department:
- _id: JiFr
- _id: GradSch
- _id: NanoFab
- _id: Bio
doi: 10.1111/jipb.70309
external_id:
pmid:
- '42271607'
fulldoi: https://doi.org/10.1111/jipb.70309
has_accepted_license: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1111/jipb.70309
month: '06'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 8f347782-16d5-11f0-9cad-8c19706ee739
grant_number: '101142681'
name: Cyclic nucleotides as second messengers in plants
- _id: bd76d395-d553-11ed-ba76-f678c14f9033
grant_number: I06123
name: Peptide receptors for auxin canalization in Arabidopsis
- _id: 7bcece63-9f16-11ee-852c-ae94e099eeb6
grant_number: P37051
name: Guanylate cyclase activity of TIR1/AFBs auxin receptors
publication: Journal of Integrative Plant Biology
publication_identifier:
eissn:
- 1744-7909
issn:
- 1672-9072
publication_status: epub_ahead
publisher: Wiley
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Auxin response and PIN‐mediated transport in chlorophyte algae
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
_id: '21136'
abstract:
- lang: eng
text: The plant hormone auxin regulates growth and development through at least
two distinct signaling pathways. The nuclear pathway, involving TIR1/AFB receptors,
mediates transcription; whereas the cell surface ABP1-TMK1 auxin perception triggers
global ultrafast phosphorylation response. Here, we revisit the rich history of
the disputed ABP1 auxin receptor, highlighting recent findings of the involvement
of TMKs and other molecular components and focusing on their role in auxin canalization-mediated
development.
acknowledgement: We gratefully acknowledge the funding by the Austrian Science Fund
(FWF; I 6123-B and P 37051-B) and the European Research Council (ERC; 101142681
CYNIPS).We would like to thank Lukas Fiedler for his significant input and thoughtful
revision of this manuscript.
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Aline
full_name: Monzer, Aline
id: 2DB5D88C-D7B3-11E9-B8FD-7907E6697425
last_name: Monzer
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Monzer A, Friml J. Historical and mechanistic perspective on ABP1-TMK1-mediated
cell surface auxin signaling. npj Science of Plants. 2025;1(1):2. doi:10.1038/s44383-025-00002-8
apa: Monzer, A., & Friml, J. (2025). Historical and mechanistic perspective
on ABP1-TMK1-mediated cell surface auxin signaling. Npj Science of Plants.
Springer Nature. https://doi.org/10.1038/s44383-025-00002-8
chicago: Monzer, Aline, and Jiří Friml. “Historical and Mechanistic Perspective
on ABP1-TMK1-Mediated Cell Surface Auxin Signaling.” Npj Science of Plants.
Springer Nature, 2025. https://doi.org/10.1038/s44383-025-00002-8.
ieee: A. Monzer and J. Friml, “Historical and mechanistic perspective on ABP1-TMK1-mediated
cell surface auxin signaling.,” npj Science of Plants, vol. 1, no. 1. Springer
Nature, p. 2, 2025.
ista: Monzer A, Friml J. 2025. Historical and mechanistic perspective on ABP1-TMK1-mediated
cell surface auxin signaling. npj Science of Plants. 1(1), 2.
mla: Monzer, Aline, and Jiří Friml. “Historical and Mechanistic Perspective on ABP1-TMK1-Mediated
Cell Surface Auxin Signaling.” Npj Science of Plants, vol. 1, no. 1, Springer
Nature, 2025, p. 2, doi:10.1038/s44383-025-00002-8.
short: A. Monzer, J. Friml, Npj Science of Plants 1 (2025) 2.
corr_author: '1'
date_created: 2026-02-03T13:03:53Z
date_published: 2025-07-01T00:00:00Z
date_updated: 2026-02-10T09:39:20Z
day: '01'
ddc:
- '580'
department:
- _id: JiFr
- _id: GradSch
doi: 10.1038/s44383-025-00002-8
external_id:
pmid:
- '40630787'
file:
- access_level: open_access
checksum: 6c190faacf0e3bef98311dc8a12132d4
content_type: application/pdf
creator: dernst
date_created: 2026-02-10T09:35:43Z
date_updated: 2026-02-10T09:35:43Z
file_id: '21208'
file_name: 2025_NPJSciencePlants_Monzer.pdf
file_size: 974106
relation: main_file
success: 1
file_date_updated: 2026-02-10T09:35:43Z
fulldoi: https://doi.org/10.1038/s44383-025-00002-8
has_accepted_license: '1'
intvolume: ' 1'
issue: '1'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: '2'
pmid: 1
project:
- _id: bd76d395-d553-11ed-ba76-f678c14f9033
grant_number: I06123
name: Peptide receptors for auxin canalization in Arabidopsis
- _id: 7bcece63-9f16-11ee-852c-ae94e099eeb6
grant_number: P37051
name: Guanylate cyclase activity of TIR1/AFBs auxin receptors
- _id: 8f347782-16d5-11f0-9cad-8c19706ee739
grant_number: '101142681'
name: Cyclic nucleotides as second messengers in plants
publication: npj Science of Plants
publication_identifier:
eissn:
- 3005-1401
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Historical and mechanistic perspective on ABP1-TMK1-mediated cell surface auxin
signaling.
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 1
year: '2025'
...
---
OA_place: publisher
OA_type: hybrid
_id: '19423'
abstract:
- lang: eng
text: "Auxin, indole-3-acetic acid (IAA), is a key phytohormone with diverse morphogenic
roles in land plants, but its function and transport mechanisms in algae remain
poorly understood. We therefore aimed to explore the role of IAA in a complex,
streptophyte algae Chara braunii.\r\nHere, we described novel responses of C.
braunii to IAA and characterized two homologs of PIN auxin efflux carriers: CbPINa
and CbPINc. We determined their localization in C. braunii using epitope-specific
antibodies and tested their function in heterologous land plant models. Further,
using phosphoproteomic analysis, we identified IAA-induced phosphorylation events.\r\nThe
thallus regeneration assay showed that IAA promotes thallus elongation and side
branch development. Immunolocalization of CbPINa and CbPINc confirmed their presence
on the plasma membrane of vegetative and generative cells of C. braunii. However,
functional assays in tobacco BY-2 cells demonstrated that CbPINa affects auxin
transport, whereas CbPINc does not. The IAA is effective in the acceleration of
cytoplasmic streaming and the phosphorylation of evolutionary conserved targets
such as homolog of RAF-like kinase.\r\nThese findings suggest that, although canonical
PIN-mediated auxin transport mechanisms might not be fully conserved in Chara,
IAA is involved in morphogenesis and fast signaling processes."
acknowledgement: 'This work was supported by funding from the Czech Science Foundation
project no. 20-13587S to JP and SV, Charles University Grant Agency projects no.
289523 to KK and no. 393422 to VS, a DOC fellowship of the Austrian Academy of Sciences
to AS, and the Austrian Science Fund (FWF): I 6123-B to JF. The authors acknowledge
the Imaging Facility of the Institute of Experimental Botany AS CR supported by
the MEYS CR (LM2023050 Czech-BioImaging), the Czech Academy of Sciences and IEB
AS CR, and Viničná Microscopy Core Facility cofinanced by the Czech-BioImaging large
RI project LM2023050. Computational resources were provided by the e-INFRA CZ project
(ID:90254), supported by the MEYS CR. The authors would like to thank Ilse Foissner
and Margit Höftberger for discussing details of immunostaining protocol, Katarzyna
Retzer and Jan Martinek for help with western blots, Anna Kampová for help with
phosphoproteome sampling, Anja Holzhausen and MadLAnd for providing Chara braunii
strain S276, and Roman Skokan for valuable discussion. Open access publishing facilitated
by Univerzita Karlova, as part of the Wiley - CzechELib agreement.'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: K
full_name: Kurtović, K
last_name: Kurtović
- first_name: S
full_name: Vosolsobě, S
last_name: Vosolsobě
- first_name: D
full_name: Nedvěd, D
last_name: Nedvěd
- first_name: K
full_name: Müller, K
last_name: Müller
- first_name: PI
full_name: Dobrev, PI
last_name: Dobrev
- first_name: V
full_name: Schmidt, V
last_name: Schmidt
- first_name: P
full_name: Piszczek, P
last_name: Piszczek
- first_name: A
full_name: Kuhn, A
last_name: Kuhn
- first_name: Adrijana
full_name: Smoljan, Adrijana
id: cced8a85-223e-11ed-af04-b0596c55053b
last_name: Smoljan
- first_name: TJ
full_name: Fisher, TJ
last_name: Fisher
- first_name: D
full_name: Weijers, D
last_name: Weijers
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: JL
full_name: Bowman, JL
last_name: Bowman
- first_name: J
full_name: Petrášek, J
last_name: Petrášek
citation:
ama: Kurtović K, Vosolsobě S, Nedvěd D, et al. The role of indole-3-acetic acid
and characterization of PIN transporters in complex streptophyte alga Chara braunii.
New Phytologist. 2025;246(3):1066-1083. doi:10.1111/nph.70019
apa: Kurtović, K., Vosolsobě, S., Nedvěd, D., Müller, K., Dobrev, P., Schmidt, V.,
… Petrášek, J. (2025). The role of indole-3-acetic acid and characterization of
PIN transporters in complex streptophyte alga Chara braunii. New Phytologist.
Wiley. https://doi.org/10.1111/nph.70019
chicago: Kurtović, K, S Vosolsobě, D Nedvěd, K Müller, PI Dobrev, V Schmidt, P Piszczek,
et al. “The Role of Indole-3-Acetic Acid and Characterization of PIN Transporters
in Complex Streptophyte Alga Chara Braunii.” New Phytologist. Wiley, 2025.
https://doi.org/10.1111/nph.70019.
ieee: K. Kurtović et al., “The role of indole-3-acetic acid and characterization
of PIN transporters in complex streptophyte alga Chara braunii,” New Phytologist,
vol. 246, no. 3. Wiley, pp. 1066–1083, 2025.
ista: Kurtović K, Vosolsobě S, Nedvěd D, Müller K, Dobrev P, Schmidt V, Piszczek
P, Kuhn A, Smoljan A, Fisher T, Weijers D, Friml J, Bowman J, Petrášek J. 2025.
The role of indole-3-acetic acid and characterization of PIN transporters in complex
streptophyte alga Chara braunii. New Phytologist. 246(3), 1066–1083.
mla: Kurtović, K., et al. “The Role of Indole-3-Acetic Acid and Characterization
of PIN Transporters in Complex Streptophyte Alga Chara Braunii.” New Phytologist,
vol. 246, no. 3, Wiley, 2025, pp. 1066–83, doi:10.1111/nph.70019.
short: K. Kurtović, S. Vosolsobě, D. Nedvěd, K. Müller, P. Dobrev, V. Schmidt, P.
Piszczek, A. Kuhn, A. Smoljan, T. Fisher, D. Weijers, J. Friml, J. Bowman, J.
Petrášek, New Phytologist 246 (2025) 1066–1083.
date_created: 2025-03-19T09:45:11Z
date_published: 2025-05-01T00:00:00Z
date_updated: 2025-09-30T11:11:18Z
day: '01'
ddc:
- '580'
department:
- _id: JiFr
doi: 10.1111/nph.70019
external_id:
isi:
- '001438711600001'
pmid:
- '40047465'
file:
- access_level: open_access
checksum: 861c9bf47e7a7766ed03e6d85bd4f6dc
content_type: application/pdf
creator: dernst
date_created: 2025-04-16T08:03:36Z
date_updated: 2025-04-16T08:03:36Z
file_id: '19571'
file_name: 2025_NewPhytologist_Kurtovic.pdf
file_size: 12841729
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success: 1
file_date_updated: 2025-04-16T08:03:36Z
fulldoi: https://doi.org/10.1111/nph.70019
has_accepted_license: '1'
intvolume: ' 246'
isi: 1
issue: '3'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
page: 1066-1083
pmid: 1
project:
- _id: bd76d395-d553-11ed-ba76-f678c14f9033
grant_number: I06123
name: Peptide receptors for auxin canalization in Arabidopsis
publication: New Phytologist
publication_identifier:
issn:
- 1469-8137
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: The role of indole-3-acetic acid and characterization of PIN transporters in
complex streptophyte alga Chara braunii
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 246
year: '2025'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '20635'
abstract:
- lang: eng
text: Plants have evolved sophisticated mechanisms to adapt to environmental changes,
with root gravitropism playing a pivotal role in nutrient and water acquisition.
Our study reveals that SnRK2 kinases (SnRK2.2 and SnRK2.3) are critical regulators
of root gravitropism through their direct phosphorylation of the auxin transporter
PIN2 at S259. We demonstrate that SnRK2s-mediated phosphorylation modulates both
the polar localization and transport activity of PIN2. Importantly, SnRK2s function
antagonistically to the AGCVIII kinase PID, which phosphorylates PIN2 at a distinct
site (S258), establishing a regulatory balance essential for adaptive root growth.
Structural modeling and phosphorylation assays further suggest that SnRK2s-mediated
phosphorylation at S259 sterically hinders access of PID to S258, providing a
mechanistic basis for their antagonistic relationship. These findings uncover
a novel regulatory mechanism, by which plants fine-tune root developmental programs
to adapt to environmental stimuli, highlighting the evolutionary significance
of multilayered kinase-mediated regulation in plant adaptation.
acknowledgement: This research was funded by Biological Breeding-National Science
and Technology Major Project (2023ZD0407201), China Postdoctoral Science Foundation
(2024M763575), China Agricultural University Fund (2025RC042), Chinese Universities
Scientific Fund (2024RC031), and Austrian Science Fund (FWF; I 6123-B).
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: F
full_name: Sheng, F
last_name: Sheng
- first_name: Y
full_name: Gao, Y
last_name: Gao
- first_name: Y
full_name: Wang, Y
last_name: Wang
- first_name: Y
full_name: Li, Y
last_name: Li
- first_name: JA
full_name: Zhang, JA
last_name: Zhang
- first_name: Z
full_name: Zhang, Z
last_name: Zhang
- first_name: X
full_name: Qin, X
last_name: Qin
- first_name: S
full_name: Zhang, S
last_name: Zhang
- first_name: W
full_name: Song, W
last_name: Song
- first_name: J
full_name: Li, J
last_name: Li
- first_name: Y
full_name: Guo, Y
last_name: Guo
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Z
full_name: Gong, Z
last_name: Gong
- first_name: Q
full_name: Zhang, Q
last_name: Zhang
- first_name: J
full_name: Zhang, J
last_name: Zhang
citation:
ama: Sheng F, Gao Y, Wang Y, et al. Antagonistic SnRK2 and PID kinases’ action on
auxin transport-mediated root gravitropism. Proceedings of the National Academy
of Sciences. 2025;122(39):e2512274122. doi:10.1073/pnas.2512274122
apa: Sheng, F., Gao, Y., Wang, Y., Li, Y., Zhang, J., Zhang, Z., … Zhang, J. (2025).
Antagonistic SnRK2 and PID kinases’ action on auxin transport-mediated root gravitropism.
Proceedings of the National Academy of Sciences. National Academy of Sciences.
https://doi.org/10.1073/pnas.2512274122
chicago: Sheng, F, Y Gao, Y Wang, Y Li, JA Zhang, Z Zhang, X Qin, et al. “Antagonistic
SnRK2 and PID Kinases’ Action on Auxin Transport-Mediated Root Gravitropism.”
Proceedings of the National Academy of Sciences. National Academy of Sciences,
2025. https://doi.org/10.1073/pnas.2512274122.
ieee: F. Sheng et al., “Antagonistic SnRK2 and PID kinases’ action on auxin
transport-mediated root gravitropism,” Proceedings of the National Academy
of Sciences, vol. 122, no. 39. National Academy of Sciences, p. e2512274122,
2025.
ista: Sheng F, Gao Y, Wang Y, Li Y, Zhang J, Zhang Z, Qin X, Zhang S, Song W, Li
J, Guo Y, Friml J, Gong Z, Zhang Q, Zhang J. 2025. Antagonistic SnRK2 and PID
kinases’ action on auxin transport-mediated root gravitropism. Proceedings of
the National Academy of Sciences. 122(39), e2512274122.
mla: Sheng, F., et al. “Antagonistic SnRK2 and PID Kinases’ Action on Auxin Transport-Mediated
Root Gravitropism.” Proceedings of the National Academy of Sciences, vol.
122, no. 39, National Academy of Sciences, 2025, p. e2512274122, doi:10.1073/pnas.2512274122.
short: F. Sheng, Y. Gao, Y. Wang, Y. Li, J. Zhang, Z. Zhang, X. Qin, S. Zhang, W.
Song, J. Li, Y. Guo, J. Friml, Z. Gong, Q. Zhang, J. Zhang, Proceedings of the
National Academy of Sciences 122 (2025) e2512274122.
date_created: 2025-11-12T10:03:20Z
date_published: 2025-09-23T00:00:00Z
date_updated: 2026-02-16T12:32:51Z
day: '23'
ddc:
- '580'
department:
- _id: JiFr
doi: 10.1073/pnas.2512274122
external_id:
isi:
- '001589177800001'
pmid:
- '40986351'
file:
- access_level: open_access
checksum: 38b723a909bf321d7ee537c9d064aa25
content_type: application/pdf
creator: dernst
date_created: 2025-11-24T13:48:09Z
date_updated: 2025-11-24T13:48:09Z
file_id: '20681'
file_name: 2025_PNAS_Sheng.pdf
file_size: 2667764
relation: main_file
success: 1
file_date_updated: 2025-11-24T13:48:09Z
fulldoi: https://doi.org/10.1073/pnas.2512274122
has_accepted_license: '1'
intvolume: ' 122'
isi: 1
issue: '39'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: e2512274122
pmid: 1
project:
- _id: bd76d395-d553-11ed-ba76-f678c14f9033
grant_number: I06123
name: Peptide receptors for auxin canalization in Arabidopsis
publication: Proceedings of the National Academy of Sciences
publication_identifier:
eissn:
- 1091-6490
issn:
- 0027-8424
publication_status: published
publisher: National Academy of Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: Antagonistic SnRK2 and PID kinases' action on auxin transport-mediated root
gravitropism
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 122
year: '2025'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '20656'
abstract:
- lang: eng
text: Phytohormone auxin and its directional transport mediate much of the remarkably
plastic development of higher plants. Positive feedback between auxin signaling
and transport is a prerequisite for (1) self-organizing processes, including vascular
tissue formation, and (2) directional growth responses such as gravitropism. Here,
we identify a mechanism by which auxin signaling directly targets PIN auxin transporters.
Via the cell-surface AUXIN-BINDING PROTEIN1 (ABP1)-TRANSMEMBRANE KINASE 1 (TMK1)
receptor module, auxin rapidly induces phosphorylation and thus stabilization
of PIN2. Following gravistimulation, initial auxin asymmetry activates autophosphorylation
of the TMK1 kinase. This induces TMK1 interaction with and phosphorylation of
PIN2, stabilizing PIN2 at the lower root side, thus reinforcing asymmetric auxin
flow for root bending. Upstream of TMK1 in this regulation, ABP1 acts redundantly
with the root-expressed ABP1-LIKE 3 (ABL3) auxin receptor. Such positive feedback
between cell-surface auxin signaling and PIN-mediated polar auxin transport is
fundamental for robust root gravitropism and presumably for other self-organizing
developmental phenomena.
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
acknowledgement: We gratefully acknowledge Tongda Xu for experimental, material, and
conceptual support. We thank William Gray for providing material, Nataliia Gnyliukh
and Ema Cervenova for help with manuscript preparation, and Julia Schmid for help
with cloning. We thank Dolf Weijers, Mark Roosjen, and Andre Kuhn for discussions
and support with phospho-proteomic analyses. We thank the Bioimaging and Life Science
facilities at the Institute of Science and Technology Austria (ISTA) for their excellent
service and assistance. The research leading to these results has received funding
from the European Union (ERC, CYNIPS, 101142681) and Austrian Science Fund (FWF;
I 6123-B) to J.F., and Y.J. was funded by ERC no. 3363360-APPL under FP/2007-2013.
L.R. was supported by the FP7-PEOPLE-2011-COFUND ISTFELLOW program (IC1023FELL01)
and the European Molecular Biology Organization (EMBO) long-term postdoctoral fellowship
(ALTF 985-2016). S.T. was supported by the National Natural Science Foundation of
China (32321001, 32570366). The work of J.H. was supported by the project JG_2024_003
implemented within the Palacký University Young Researcher Grant.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Lesia
full_name: Rodriguez Solovey, Lesia
id: 3922B506-F248-11E8-B48F-1D18A9856A87
last_name: Rodriguez Solovey
orcid: 0000-0002-7244-7237
- first_name: Lukas
full_name: Fiedler, Lukas
id: 7c417475-8972-11ed-ae7b-8b674ca26986
last_name: Fiedler
- first_name: Minxia
full_name: Zou, Minxia
id: 5c243f41-03f3-11ec-841c-96faf48a7ef9
last_name: Zou
- first_name: Caterina
full_name: Giannini, Caterina
id: e3fdddd5-f6e0-11ea-865d-ca99ee6367f4
last_name: Giannini
- first_name: Aline
full_name: Monzer, Aline
id: 2DB5D88C-D7B3-11E9-B8FD-7907E6697425
last_name: Monzer
- first_name: Dmitrii
full_name: Vladimirtsev, Dmitrii
id: 60466724-5355-11ee-ae5a-fa55e8f99c3d
last_name: Vladimirtsev
- first_name: Marek
full_name: Randuch, Marek
id: 6ac4636d-15b2-11ec-abd3-fb8df79972ae
last_name: Randuch
- first_name: Yongfan
full_name: Yu, Yongfan
last_name: Yu
- first_name: Zuzana
full_name: Gelová, Zuzana
id: 0AE74790-0E0B-11E9-ABC7-1ACFE5697425
last_name: Gelová
orcid: 0000-0003-4783-1752
- first_name: Inge
full_name: Verstraeten, Inge
id: 362BF7FE-F248-11E8-B48F-1D18A9856A87
last_name: Verstraeten
orcid: 0000-0001-7241-2328
- first_name: Jakub
full_name: Hajny, Jakub
id: 4800CC20-F248-11E8-B48F-1D18A9856A87
last_name: Hajny
orcid: 0000-0003-2140-7195
- first_name: Meng
full_name: Chen, Meng
last_name: Chen
- first_name: Shutang
full_name: Tan, Shutang
id: 2DE75584-F248-11E8-B48F-1D18A9856A87
last_name: Tan
orcid: 0000-0002-0471-8285
- first_name: Lukas
full_name: Hörmayer, Lukas
id: 2EEE7A2A-F248-11E8-B48F-1D18A9856A87
last_name: Hörmayer
orcid: 0000-0001-8295-2926
- first_name: Lanxin
full_name: Li, Lanxin
id: 367EF8FA-F248-11E8-B48F-1D18A9856A87
last_name: Li
orcid: 0000-0002-5607-272X
- first_name: Maria Mar
full_name: Marques-Bueno, Maria Mar
last_name: Marques-Bueno
- first_name: Zainab
full_name: Quddoos, Zainab
id: 32ff3c64-04a0-11f0-a50f-d0c45bfac466
last_name: Quddoos
- first_name: Gergely
full_name: Molnar, Gergely
id: 34F1AF46-F248-11E8-B48F-1D18A9856A87
last_name: Molnar
- first_name: Ivan
full_name: Kulich, Ivan
id: 57a1567c-8314-11eb-9063-c9ddc3451a54
last_name: Kulich
- first_name: Yvon
full_name: Jaillais, Yvon
last_name: Jaillais
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Rodriguez Solovey L, Fiedler L, Zou M, et al. ABP1/ABL3-TMK1 cell-surface auxin
signaling targets PIN2-mediated auxin fluxes for root gravitropism. Cell.
2025;188(22):6138-6150.e17. doi:10.1016/j.cell.2025.08.026
apa: Rodriguez Solovey, L., Fiedler, L., Zou, M., Giannini, C., Monzer, A., Vladimirtsev,
D., … Friml, J. (2025). ABP1/ABL3-TMK1 cell-surface auxin signaling targets PIN2-mediated
auxin fluxes for root gravitropism. Cell. Elsevier. https://doi.org/10.1016/j.cell.2025.08.026
chicago: Rodriguez Solovey, Lesia, Lukas Fiedler, Minxia Zou, Caterina Giannini,
Aline Monzer, Dmitrii Vladimirtsev, Marek Randuch, et al. “ABP1/ABL3-TMK1 Cell-Surface
Auxin Signaling Targets PIN2-Mediated Auxin Fluxes for Root Gravitropism.” Cell.
Elsevier, 2025. https://doi.org/10.1016/j.cell.2025.08.026.
ieee: L. Rodriguez Solovey et al., “ABP1/ABL3-TMK1 cell-surface auxin signaling
targets PIN2-mediated auxin fluxes for root gravitropism,” Cell, vol. 188,
no. 22. Elsevier, p. 6138–6150.e17, 2025.
ista: Rodriguez Solovey L, Fiedler L, Zou M, Giannini C, Monzer A, Vladimirtsev
D, Randuch M, Yu Y, Gelová Z, Verstraeten I, Hajny J, Chen M, Tan S, Hörmayer
L, Li L, Marques-Bueno MM, Quddoos Z, Molnar G, Kulich I, Jaillais Y, Friml J.
2025. ABP1/ABL3-TMK1 cell-surface auxin signaling targets PIN2-mediated auxin
fluxes for root gravitropism. Cell. 188(22), 6138–6150.e17.
mla: Rodriguez Solovey, Lesia, et al. “ABP1/ABL3-TMK1 Cell-Surface Auxin Signaling
Targets PIN2-Mediated Auxin Fluxes for Root Gravitropism.” Cell, vol. 188,
no. 22, Elsevier, 2025, p. 6138–6150.e17, doi:10.1016/j.cell.2025.08.026.
short: L. Rodriguez Solovey, L. Fiedler, M. Zou, C. Giannini, A. Monzer, D. Vladimirtsev,
M. Randuch, Y. Yu, Z. Gelová, I. Verstraeten, J. Hajny, M. Chen, S. Tan, L. Hörmayer,
L. Li, M.M. Marques-Bueno, Z. Quddoos, G. Molnar, I. Kulich, Y. Jaillais, J. Friml,
Cell 188 (2025) 6138–6150.e17.
corr_author: '1'
date_created: 2025-11-19T09:44:31Z
date_published: 2025-10-30T00:00:00Z
date_updated: 2026-07-06T12:51:13Z
day: '30'
ddc:
- '580'
department:
- _id: JiFr
- _id: XiFe
doi: 10.1016/j.cell.2025.08.026
ec_funded: 1
external_id:
isi:
- '001616077900005'
pmid:
- '41043433'
file:
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checksum: 8ac396a0806ad7f2e4e7a0c1eed712ce
content_type: application/pdf
creator: dernst
date_created: 2025-11-24T10:55:18Z
date_updated: 2025-11-24T10:55:18Z
file_id: '20679'
file_name: 2025_Cell_Rodriguez.pdf
file_size: 17825465
relation: main_file
success: 1
file_date_updated: 2025-11-24T10:55:18Z
fulldoi: https://doi.org/10.1016/j.cell.2025.08.026
has_accepted_license: '1'
intvolume: ' 188'
isi: 1
issue: '22'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
page: 6138-6150.e17
pmid: 1
project:
- _id: 8f347782-16d5-11f0-9cad-8c19706ee739
grant_number: '101142681'
name: Cyclic nucleotides as second messengers in plants
- _id: bd76d395-d553-11ed-ba76-f678c14f9033
grant_number: I06123
name: Peptide receptors for auxin canalization in Arabidopsis
- _id: 26060676-B435-11E9-9278-68D0E5697425
grant_number: ALTF 985-2016
name: Cell surface receptor complexes for auxin signaling in plants
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication: Cell
publication_identifier:
issn:
- 0092-8674
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
record:
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relation: earlier_version
status: public
status: public
title: ABP1/ABL3-TMK1 cell-surface auxin signaling targets PIN2-mediated auxin fluxes
for root gravitropism
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 188
year: '2025'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '20187'
abstract:
- lang: eng
text: Very long-chain fatty acids (VLCFAs), being constituents of different types
of lipids, are critical factors in plant development, presumably due to their
impact on the endomembrane system. The VLCFAs are synthesized in the endoplasmic
reticulum by a heterotetrameric enzymatic complex including β-ketoacyl CoA reductase
1 (KCR1), whose mutant is lethal. Here, we describe the ectopic shoot meristems
(esm) mutant, a viable kcr1 allele presumably affecting surface properties of
the KCR1 protein. This kcr1-2 mutant shows reduced fatty acyl elongation that
impacts VLCFAs. The kcr1-2 plants show severe defects during different stages
of development, which all correlate with defects in polar localization and subcellular
trafficking of PIN auxin transporters and resulting asymmetric auxin distribution.
Detailed analysis of KCR1 expression and patterning defects in kcr1-2 suggests
that KCR1 plays a role in delineating boundaries around meristematic and specialized
differentiating tissues, including root and shoot meristems, initiating lateral
roots, lateral root primordia, and trichomes. In these contexts, KCR1-produced
VLCFAs may act in a non-cell-autonomous manner. Viable kcr1-2 represents a useful
tool to study VLCFA roles in plant development and highlights VLCFAs as critical
developmental factors at the interface of cell polarity and tissue development.
acknowledged_ssus:
- _id: Bio
- _id: EM-Fac
- _id: LifeSc
acknowledgement: "We gratefully acknowledge the Imaging and Optics, Electron Microscopy
(especially Vanessa Zheden for technical assistance) and Life Science (in particular
Dorota Jaworska) facilities at ISTA for their continuous support. Authors would
like to thank Michelle Gallei for advice during the generation of the transgenic
lines; Zuzana Gelová for advice with DR5rev::GFP analyses; Ivan Kulich for help
and advice on trichome imaging; Aline Monzer for generous help with hypocotyl and
root analyses; Shutang Tan for help with the NGS data analysis; and Milan Župunski
for advice on abiotic stress experiments. We would like to thank Dolf Weijers for
the SOSEKI (SOK) marker line seeds. This work has benefited from the support of
IJPB's Plant Observatory platforms P0-Chem.\r\n\r\nThis work was supported by Austrian
Science Fund (FWF) (I 6123-B) and Science and Technology Department of Jiangxi Province
(20223BCJ25037) to Huibin Han. The IJPB benefits from the support of Saclay Plant
Sciences-SPS (ANR-17-EUR-0007)."
article_number: e70396
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: David
full_name: Babic, David
id: db566d23-f6e0-11ea-865d-e6f270e968e7
last_name: Babic
- first_name: Rashed
full_name: Abualia, Rashed
id: 4827E134-F248-11E8-B48F-1D18A9856A87
last_name: Abualia
orcid: 0000-0002-9357-9415
- first_name: Lukas
full_name: Fiedler, Lukas
id: 7c417475-8972-11ed-ae7b-8b674ca26986
last_name: Fiedler
- first_name: Linlin
full_name: Qi, Linlin
id: 44B04502-A9ED-11E9-B6FC-583AE6697425
last_name: Qi
orcid: 0000-0001-5187-8401
- first_name: Frédérique
full_name: Tellier, Frédérique
last_name: Tellier
- first_name: Adrijana
full_name: Smoljan, Adrijana
id: cced8a85-223e-11ed-af04-b0596c55053b
last_name: Smoljan
- first_name: Hana
full_name: Rakusova, Hana
id: 4CAAA450-78D2-11EA-8E57-B40A396E08BA
last_name: Rakusova
- first_name: Petr
full_name: Valošek, Petr
id: 3CDB6F94-F248-11E8-B48F-1D18A9856A87
last_name: Valošek
- first_name: Huibin
full_name: Han, Huibin
id: 31435098-F248-11E8-B48F-1D18A9856A87
last_name: Han
- first_name: Eva
full_name: Benková, Eva
id: 38F4F166-F248-11E8-B48F-1D18A9856A87
last_name: Benková
orcid: 0000-0002-8510-9739
- first_name: Jean Denis
full_name: Faure, Jean Denis
last_name: Faure
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Babic D, Abualia R, Fiedler L, et al. Biosynthesis of very long-chain fatty
acids is required for Arabidopsis auxin-mediated embryonic and post-embryonic
development. Plant Journal. 2025;123(3). doi:10.1111/tpj.70396
apa: Babic, D., Abualia, R., Fiedler, L., Qi, L., Tellier, F., Smoljan, A., … Friml,
J. (2025). Biosynthesis of very long-chain fatty acids is required for Arabidopsis
auxin-mediated embryonic and post-embryonic development. Plant Journal.
Wiley. https://doi.org/10.1111/tpj.70396
chicago: Babic, David, Rashed Abualia, Lukas Fiedler, Linlin Qi, Frédérique Tellier,
Adrijana Smoljan, Hana Rakusova, et al. “Biosynthesis of Very Long-Chain Fatty
Acids Is Required for Arabidopsis Auxin-Mediated Embryonic and Post-Embryonic
Development.” Plant Journal. Wiley, 2025. https://doi.org/10.1111/tpj.70396.
ieee: D. Babic et al., “Biosynthesis of very long-chain fatty acids is required
for Arabidopsis auxin-mediated embryonic and post-embryonic development,” Plant
Journal, vol. 123, no. 3. Wiley, 2025.
ista: Babic D, Abualia R, Fiedler L, Qi L, Tellier F, Smoljan A, Rakusova H, Valošek
P, Han H, Benková E, Faure JD, Friml J. 2025. Biosynthesis of very long-chain
fatty acids is required for Arabidopsis auxin-mediated embryonic and post-embryonic
development. Plant Journal. 123(3), e70396.
mla: Babic, David, et al. “Biosynthesis of Very Long-Chain Fatty Acids Is Required
for Arabidopsis Auxin-Mediated Embryonic and Post-Embryonic Development.” Plant
Journal, vol. 123, no. 3, e70396, Wiley, 2025, doi:10.1111/tpj.70396.
short: D. Babic, R. Abualia, L. Fiedler, L. Qi, F. Tellier, A. Smoljan, H. Rakusova,
P. Valošek, H. Han, E. Benková, J.D. Faure, J. Friml, Plant Journal 123 (2025).
corr_author: '1'
date_created: 2025-08-17T22:01:36Z
date_published: 2025-08-01T00:00:00Z
date_updated: 2026-10-13T22:30:12Z
day: '01'
ddc:
- '580'
department:
- _id: EvBe
- _id: JiFr
- _id: GradSch
doi: 10.1111/tpj.70396
external_id:
isi:
- '001547884300001'
pmid:
- '40782342'
file:
- access_level: open_access
checksum: 1cdc3341d2d23101abca72521f1f23cb
content_type: application/pdf
creator: dernst
date_created: 2025-09-01T14:09:31Z
date_updated: 2025-09-01T14:09:31Z
file_id: '20264'
file_name: 2025_PlantJournal_Babic.pdf
file_size: 5791111
relation: main_file
success: 1
file_date_updated: 2025-09-01T14:09:31Z
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intvolume: ' 123'
isi: 1
issue: '3'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: bd76d395-d553-11ed-ba76-f678c14f9033
grant_number: I06123
name: Peptide receptors for auxin canalization in Arabidopsis
publication: Plant Journal
publication_identifier:
eissn:
- 1365-313X
issn:
- 0960-7412
publication_status: published
publisher: Wiley
quality_controlled: '1'
related_material:
record:
- id: '20362'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Biosynthesis of very long-chain fatty acids is required for Arabidopsis auxin-mediated
embryonic and post-embryonic development
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 123
year: '2025'
...
---
OA_place: publisher
OA_type: hybrid
_id: '15330'
abstract:
- lang: eng
text: Clathrin-mediated endocytosis (CME) is vital for the regulation of plant growth
and development by controlling plasma membrane protein composition and cargo uptake.
CME relies on the precise recruitment of regulators for vesicle maturation and
release. Homologues of components of mammalian vesicle scission are strong candidates
to be part of the scission machinery in plants, but the precise roles of these
proteins in this process are not fully understood. Here, we characterised the
roles of Plant Dynamin-Related Proteins 2 (DRP2s) and SH3-domain containing protein
2 (SH3P2), the plant homologue to Dynamins’ recruiters, like Endophilin and Amphiphysin,
in the CME by combining high-resolution imaging of endocytic events in vivo and
characterisation of the purified proteins in vitro. Although DRP2s and SH3P2 arrive
similarly late during CME and physically interact, genetic analysis of the sh3p123
triple-mutant and complementation assays with non-SH3P2-interacting DRP2 variants
suggests that SH3P2 does not directly recruit DRP2s to the site of endocytosis.
These observations imply that despite the presence of many well-conserved endocytic
components, plants have acquired a distinct mechanism for CME.
acknowledged_ssus:
- _id: EM-Fac
- _id: LifeSc
- _id: Bio
acknowledgement: "Nataliia Gnyliukh was partially funded by the European Union’s Horizon
2020 research and\r\ninnovation program (2018-2020) under the Marie Sklodowska-Curie
Grant (agreement no.\r\n665385). Taif University Researchers Supporting Project:
TURSP-HC2022/02. and Austrian\r\nScience Fund (FWF): I 6123-B.We thank Prof. Eileen
Lafer and Liping Wang for their suggestions regarding the optimisation of protein
expression and purification. We thank Prof. Sebastian Y. Bednarek for the useful
comments and constructive criticism of the project. We thank Maciek Adamowski for
providing genetic material. This research was supported by the Scientific Service
Units (SSU) of IST-Austria through resources provided by the Electron microscopy
(EMF), Lab Support Facility (LSF) (particularly Dorota Jaworska) and the Bioimaging
Facility (BIF)."
article_number: jcs.261720
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Nataliia
full_name: Gnyliukh, Nataliia
id: 390C1120-F248-11E8-B48F-1D18A9856A87
last_name: Gnyliukh
orcid: 0000-0002-2198-0509
- first_name: Alexander J
full_name: Johnson, Alexander J
id: 46A62C3A-F248-11E8-B48F-1D18A9856A87
last_name: Johnson
orcid: 0000-0002-2739-8843
- first_name: MK
full_name: Nagel, MK
last_name: Nagel
- first_name: Aline
full_name: Monzer, Aline
id: 2DB5D88C-D7B3-11E9-B8FD-7907E6697425
last_name: Monzer
- first_name: David
full_name: Babic, David
id: db566d23-f6e0-11ea-865d-e6f270e968e7
last_name: Babic
- first_name: Annamaria
full_name: Hlavata, Annamaria
id: 36062FEC-F248-11E8-B48F-1D18A9856A87
last_name: Hlavata
- first_name: SS
full_name: Alotaibi, SS
last_name: Alotaibi
- first_name: E
full_name: Isono, E
last_name: Isono
- first_name: Martin
full_name: Loose, Martin
id: 462D4284-F248-11E8-B48F-1D18A9856A87
last_name: Loose
orcid: 0000-0001-7309-9724
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Gnyliukh N, Johnson AJ, Nagel M, et al. Role of dynamin-related proteins 2
and SH3P2 in clathrin-mediated endocytosis in Arabidopsis thaliana. Journal
of Cell Science. 2024;137(8). doi:10.1242/jcs.261720
apa: Gnyliukh, N., Johnson, A. J., Nagel, M., Monzer, A., Babic, D., Hlavata, A.,
… Friml, J. (2024). Role of dynamin-related proteins 2 and SH3P2 in clathrin-mediated
endocytosis in Arabidopsis thaliana. Journal of Cell Science. The Company
of Biologists. https://doi.org/10.1242/jcs.261720
chicago: Gnyliukh, Nataliia, Alexander J Johnson, MK Nagel, Aline Monzer, David
Babic, Annamaria Hlavata, SS Alotaibi, E Isono, Martin Loose, and Jiří Friml.
“Role of Dynamin-Related Proteins 2 and SH3P2 in Clathrin-Mediated Endocytosis
in Arabidopsis Thaliana.” Journal of Cell Science. The Company of Biologists,
2024. https://doi.org/10.1242/jcs.261720.
ieee: N. Gnyliukh et al., “Role of dynamin-related proteins 2 and SH3P2 in
clathrin-mediated endocytosis in Arabidopsis thaliana,” Journal of Cell Science,
vol. 137, no. 8. The Company of Biologists, 2024.
ista: Gnyliukh N, Johnson AJ, Nagel M, Monzer A, Babic D, Hlavata A, Alotaibi S,
Isono E, Loose M, Friml J. 2024. Role of dynamin-related proteins 2 and SH3P2
in clathrin-mediated endocytosis in Arabidopsis thaliana. Journal of Cell Science.
137(8), jcs. 261720.
mla: Gnyliukh, Nataliia, et al. “Role of Dynamin-Related Proteins 2 and SH3P2 in
Clathrin-Mediated Endocytosis in Arabidopsis Thaliana.” Journal of Cell Science,
vol. 137, no. 8, jcs. 261720, The Company of Biologists, 2024, doi:10.1242/jcs.261720.
short: N. Gnyliukh, A.J. Johnson, M. Nagel, A. Monzer, D. Babic, A. Hlavata, S.
Alotaibi, E. Isono, M. Loose, J. Friml, Journal of Cell Science 137 (2024).
corr_author: '1'
date_created: 2024-04-19T09:54:59Z
date_published: 2024-04-01T00:00:00Z
date_updated: 2025-09-04T13:49:45Z
day: '01'
ddc:
- '570'
department:
- _id: MaLo
- _id: JiFr
- _id: CaBe
doi: 10.1242/jcs.261720
ec_funded: 1
external_id:
isi:
- '001266917100005'
pmid:
- '38506228'
file:
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checksum: 6dc023f0cc7052ad3cf0a42589d2e30f
content_type: application/pdf
creator: dernst
date_created: 2025-01-09T08:41:16Z
date_updated: 2025-01-09T08:41:16Z
file_id: '18792'
file_name: 2024_JourCellScience_Gnyliukh.pdf
file_size: 25845948
relation: main_file
success: 1
file_date_updated: 2025-01-09T08:41:16Z
fulldoi: https://doi.org/10.1242/jcs.261720
has_accepted_license: '1'
intvolume: ' 137'
isi: 1
issue: '8'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
- _id: bd76d395-d553-11ed-ba76-f678c14f9033
grant_number: I06123
name: Peptide receptors for auxin canalization in Arabidopsis
publication: Journal of Cell Science
publication_identifier:
eissn:
- 1477-9137
issn:
- 0021-9533
publication_status: published
publisher: The Company of Biologists
quality_controlled: '1'
related_material:
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relation: earlier_version
status: public
scopus_import: '1'
status: public
title: Role of dynamin-related proteins 2 and SH3P2 in clathrin-mediated endocytosis
in Arabidopsis thaliana
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 137
year: '2024'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '18582'
abstract:
- lang: eng
text: Identification of PIN exporters for auxin, the major coordinative signal in
plants, some 25 years ago, signifies a landmark in our understanding of plant-specific
mechanisms underlying development and adaptation. Auxin is directionally transported
throughout the plant body; a unique feature already envisioned by Darwin and solidified
by PINs’ discovery and characterization. The PIN-based auxin distribution network
with its complex regulations of PIN expression, localization and activity turned
out to underlie a remarkable multitude of developmental processes and represents
means to integrate endogenous and environmental signals. Given the recent anniversary,
we here summarize past and current developments in this exciting field.
acknowledgement: We gratefully acknowledge Leo Gälweiler for authorizing his PIN1
story. We would like to thank Yuanrong Pei for invaluable help with preparing figures.
Work in the lab of C.L. is supported by grants from the Austrian Science Fund (PAT
8419423) and by the Gesellschaft für Forschungsförderung Niederösterreich m.b.H.
(FTI19-008). The lab of J.F. is supported by the Austrian Science Fund (I 6123-B
and P 37051-B).
article_number: '9904'
article_processing_charge: Yes
article_type: original
author:
- first_name: Christian
full_name: Luschnig, Christian
last_name: Luschnig
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Luschnig C, Friml J. Over 25 years of decrypting PIN-mediated plant development.
Nature Communications. 2024;15. doi:10.1038/s41467-024-54240-y
apa: Luschnig, C., & Friml, J. (2024). Over 25 years of decrypting PIN-mediated
plant development. Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-024-54240-y
chicago: Luschnig, Christian, and Jiří Friml. “Over 25 Years of Decrypting PIN-Mediated
Plant Development.” Nature Communications. Springer Nature, 2024. https://doi.org/10.1038/s41467-024-54240-y.
ieee: C. Luschnig and J. Friml, “Over 25 years of decrypting PIN-mediated plant
development,” Nature Communications, vol. 15. Springer Nature, 2024.
ista: Luschnig C, Friml J. 2024. Over 25 years of decrypting PIN-mediated plant
development. Nature Communications. 15, 9904.
mla: Luschnig, Christian, and Jiří Friml. “Over 25 Years of Decrypting PIN-Mediated
Plant Development.” Nature Communications, vol. 15, 9904, Springer Nature,
2024, doi:10.1038/s41467-024-54240-y.
short: C. Luschnig, J. Friml, Nature Communications 15 (2024).
corr_author: '1'
date_created: 2024-11-24T23:01:48Z
date_published: 2024-12-01T00:00:00Z
date_updated: 2025-09-08T14:53:48Z
day: '01'
ddc:
- '580'
department:
- _id: JiFr
doi: 10.1038/s41467-024-54240-y
external_id:
isi:
- '001356232600004'
pmid:
- '39548100'
file:
- access_level: open_access
checksum: 3a31af06f52100d287f1e9d9c2aa1d40
content_type: application/pdf
creator: dernst
date_created: 2024-12-03T14:10:54Z
date_updated: 2024-12-03T14:10:54Z
file_id: '18615'
file_name: 2024_NatureComm_Luschnig.pdf
file_size: 1426555
relation: main_file
success: 1
file_date_updated: 2024-12-03T14:10:54Z
fulldoi: https://doi.org/10.1038/s41467-024-54240-y
has_accepted_license: '1'
intvolume: ' 15'
isi: 1
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: bd76d395-d553-11ed-ba76-f678c14f9033
grant_number: I06123
name: Peptide receptors for auxin canalization in Arabidopsis
- _id: 7bcece63-9f16-11ee-852c-ae94e099eeb6
grant_number: P37051
name: Guanylate cyclase activity of TIR1/AFBs auxin receptors
publication: Nature Communications
publication_identifier:
eissn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Over 25 years of decrypting PIN-mediated plant development
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 15
year: '2024'
...
---
OA_place: repository
OA_type: green
_id: '17377'
abstract:
- lang: eng
text: "Lateral root (LR) formation, that is vital for plant development, is one
of many auxin-modulated processes, but the underlying regulatory mechanism is
not yet fully known. Recently, \r\nGonzález-García et al. discovered the BiAux
compound and showed that it is involved in LR development via regulating specific
auxin coreceptors."
acknowledgement: "This work was supported by funding from the National Science Centre,
Poland, under the OPUS call in the Weave program and the Austrian Science Fund,
Austria project (FWF)/OPUS – Peptide receptor complexes for auxin canalization and
regeneration in Arabidopsis (grant \r\n2021/43/I/NZ1/01835) to E.M., and grant I
6123-B to J.F."
article_processing_charge: No
article_type: original
author:
- first_name: Barbara
full_name: Wójcikowska, Barbara
last_name: Wójcikowska
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Ewa
full_name: Mazur, Ewa
last_name: Mazur
citation:
ama: Wójcikowska B, Friml J, Mazur E. BiAux, a newly discovered compound triggering
auxin signaling. Trends in Plant Science. 2024;29(12):1279-1281. doi:10.1016/j.tplants.2024.07.008
apa: Wójcikowska, B., Friml, J., & Mazur, E. (2024). BiAux, a newly discovered
compound triggering auxin signaling. Trends in Plant Science. Elsevier.
https://doi.org/10.1016/j.tplants.2024.07.008
chicago: Wójcikowska, Barbara, Jiří Friml, and Ewa Mazur. “BiAux, a Newly Discovered
Compound Triggering Auxin Signaling.” Trends in Plant Science. Elsevier,
2024. https://doi.org/10.1016/j.tplants.2024.07.008.
ieee: B. Wójcikowska, J. Friml, and E. Mazur, “BiAux, a newly discovered compound
triggering auxin signaling,” Trends in Plant Science, vol. 29, no. 12.
Elsevier, pp. 1279–1281, 2024.
ista: Wójcikowska B, Friml J, Mazur E. 2024. BiAux, a newly discovered compound
triggering auxin signaling. Trends in Plant Science. 29(12), 1279–1281.
mla: Wójcikowska, Barbara, et al. “BiAux, a Newly Discovered Compound Triggering
Auxin Signaling.” Trends in Plant Science, vol. 29, no. 12, Elsevier, 2024,
pp. 1279–81, doi:10.1016/j.tplants.2024.07.008.
short: B. Wójcikowska, J. Friml, E. Mazur, Trends in Plant Science 29 (2024) 1279–1281.
corr_author: '1'
date_created: 2024-08-04T22:01:22Z
date_published: 2024-12-01T00:00:00Z
date_updated: 2025-11-24T15:13:16Z
day: '01'
ddc:
- '580'
department:
- _id: JiFr
doi: 10.1016/j.tplants.2024.07.008
external_id:
isi:
- '001375335200001'
pmid:
- '39079770'
file:
- access_level: open_access
checksum: 89a83fe25b9ec1aad8e22d134a342c09
content_type: application/pdf
creator: dernst
date_created: 2025-11-24T15:12:50Z
date_updated: 2025-11-24T15:12:50Z
file_id: '20691'
file_name: 2024_TrendsPlantScience_Wojcikowska_submittedversion.pdf
file_size: 277636
relation: main_file
success: 1
file_date_updated: 2025-11-24T15:12:50Z
fulldoi: https://doi.org/10.1016/j.tplants.2024.07.008
has_accepted_license: '1'
intvolume: ' 29'
isi: 1
issue: '12'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Submitted Version
page: 1279-1281
pmid: 1
project:
- _id: bd76d395-d553-11ed-ba76-f678c14f9033
grant_number: I06123
name: Peptide receptors for auxin canalization in Arabidopsis
publication: Trends in Plant Science
publication_identifier:
issn:
- 1360-1385
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: BiAux, a newly discovered compound triggering auxin signaling
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 29
year: '2024'
...
---
_id: '18063'
abstract:
- lang: eng
text: The developmental plasticity of the root system plays an essential role in
the adaptation of plants to the environment. Among many other signals, auxin and
its directional, intercellular transport are critical in regulating root growth
and development. In particular, the PIN-FORMED2 (PIN2) auxin exporter acts as
a key regulator of root gravitropic growth. Multiple regulators have been reported
to be involved in PIN2-mediated root growth; however, our information remains
incomplete. Here, we identified ROWY Bro1-domain proteins as important regulators
of PIN2 sorting control. Genetic analysis revealed that Arabidopsis rowy1 single
mutants and higher-order rowy1 rowy2 rowy3 triple mutants presented a wavy root
growth phenotype. Cell biological experiments revealed that ROWY1 and PIN2 colocalized
to the apical side of the plasma membrane in the root epidermis and that ROWYs
are required for correct PM targeting of PIN2. In addition, ROWYs also affected
PIN3 protein abundance in the stele, suggesting the potential involvement of additional
PIN transporters as well as other proteins. A global transcriptome analysis revealed
that ROWY genes are involved in the Fe2+ availability perception pathway. This
work establishes ROWYs as important novel regulators of root gravitropic growth
by connecting micronutrient availability to the proper subcellular targeting of
PIN auxin transporters.
acknowledgement: We thank Drs. Erika Isono (University of Constance), Grégory Vert
(University of Toulouse), and Liwen Jiang (The Chinese University of Hong Kong)
for kindly sharing published Arabidopsis lines; Dr. Yuzhou Zhang (ISTA) for help
with molecular cloning, and Drs. Melinda Abas (BOKU), Eugenia Russinova (Ghent University),
and Zhaojun Ding (Shandong University) for valuable discussions. This work was supported
by grants to S.T. from the National Natural Science Foundation of China (32321001),
the USTC Research Funds of the Double First-Class Initiative (YD9100002016), the
Research Funds from the Center for Advanced Interdisciplinary Science and Biomedicine
of IHM, the Division of Life Sciences and Medicine, the University of Science and
Technology of China (QYPY20220012), the Fundamental Research Funds for the Central
Universities (WK9100000021), and start-up funding from the University of Science
and Technology of China and the Chinese Academy of Sciences (GG9100007007, KY9100000026,
KY9100000051, and KJ2070000079). J.S. was supported by the National Natural Science
Foundation of China (31970181 and 32170342). J.F. was supported by Austrian Science
Fund (FWF; projects I6123 and P37051-B).
article_number: '1085'
article_processing_charge: Yes
article_type: original
author:
- first_name: Yakun
full_name: Peng, Yakun
last_name: Peng
- first_name: Kangkang
full_name: Ji, Kangkang
last_name: Ji
- first_name: Yanbo
full_name: Mao, Yanbo
last_name: Mao
- first_name: Yiqun
full_name: Wang, Yiqun
id: 82F537F2-B517-11E9-84D7-6433E6697425
last_name: Wang
- first_name: Barbara
full_name: Korbei, Barbara
last_name: Korbei
- first_name: Christian
full_name: Luschnig, Christian
last_name: Luschnig
- first_name: Jinbo
full_name: Shen, Jinbo
last_name: Shen
- first_name: Eva
full_name: Benková, Eva
id: 38F4F166-F248-11E8-B48F-1D18A9856A87
last_name: Benková
orcid: 0000-0002-8510-9739
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Shutang
full_name: Tan, Shutang
id: 2DE75584-F248-11E8-B48F-1D18A9856A87
last_name: Tan
orcid: 0000-0002-0471-8285
citation:
ama: Peng Y, Ji K, Mao Y, et al. Polarly localized Bro1 domain proteins regulate
PIN-FORMED abundance and root gravitropic growth in Arabidopsis. Communications
Biology. 2024;7. doi:10.1038/s42003-024-06747-9
apa: Peng, Y., Ji, K., Mao, Y., Wang, Y., Korbei, B., Luschnig, C., … Tan, S. (2024).
Polarly localized Bro1 domain proteins regulate PIN-FORMED abundance and root
gravitropic growth in Arabidopsis. Communications Biology. Springer Nature.
https://doi.org/10.1038/s42003-024-06747-9
chicago: Peng, Yakun, Kangkang Ji, Yanbo Mao, Yiqun Wang, Barbara Korbei, Christian
Luschnig, Jinbo Shen, Eva Benková, Jiří Friml, and Shutang Tan. “Polarly Localized
Bro1 Domain Proteins Regulate PIN-FORMED Abundance and Root Gravitropic Growth
in Arabidopsis.” Communications Biology. Springer Nature, 2024. https://doi.org/10.1038/s42003-024-06747-9.
ieee: Y. Peng et al., “Polarly localized Bro1 domain proteins regulate PIN-FORMED
abundance and root gravitropic growth in Arabidopsis,” Communications Biology,
vol. 7. Springer Nature, 2024.
ista: Peng Y, Ji K, Mao Y, Wang Y, Korbei B, Luschnig C, Shen J, Benková E, Friml
J, Tan S. 2024. Polarly localized Bro1 domain proteins regulate PIN-FORMED abundance
and root gravitropic growth in Arabidopsis. Communications Biology. 7, 1085.
mla: Peng, Yakun, et al. “Polarly Localized Bro1 Domain Proteins Regulate PIN-FORMED
Abundance and Root Gravitropic Growth in Arabidopsis.” Communications Biology,
vol. 7, 1085, Springer Nature, 2024, doi:10.1038/s42003-024-06747-9.
short: Y. Peng, K. Ji, Y. Mao, Y. Wang, B. Korbei, C. Luschnig, J. Shen, E. Benková,
J. Friml, S. Tan, Communications Biology 7 (2024).
das_tickbox: '1'
dataavailabilitystatement: 'The RNA-seq data for this study are available online at
the NCBI Sequence Read Archive (accession number: PRJNA1116831). Uncropped images
of the DNA gels are provided in the Supplementary Figs. 21 to 22. The source data
used to generate the plots are provided in the Supplementary Data 2.'
date_created: 2024-09-15T22:01:38Z
date_published: 2024-09-04T00:00:00Z
date_updated: 2026-10-13T22:31:29Z
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doi: 10.1038/s42003-024-06747-9
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name: Guanylate cyclase activity of TIR1/AFBs auxin receptors
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eissn:
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publication_status: published
publisher: Springer Nature
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researchdata_availability: yes (supplementary data)
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supplementarymaterial: yes
title: Polarly localized Bro1 domain proteins regulate PIN-FORMED abundance and root
gravitropic growth in Arabidopsis
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
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year: '2024'
...
---
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abstract:
- lang: eng
text: The 3′,5′-cyclic adenosine monophosphate (cAMP) is a versatile second messenger
in many mammalian signaling pathways. However, its role in plants remains not
well-recognized. Recent discovery of adenylate cyclase (AC) activity for transport
inhibitor response 1/auxin-signaling F-box proteins (TIR1/AFB) auxin receptors
and the demonstration of its importance for canonical auxin signaling put plant
cAMP research back into spotlight. This insight briefly summarizes the well-established
cAMP signaling pathways in mammalian cells and describes the turbulent and controversial
history of plant cAMP research highlighting the major progress and the unresolved
points. We also briefly review the current paradigm of auxin signaling to provide
a background for the discussion on the AC activity of TIR1/AFB auxin receptors
and its potential role in transcriptional auxin signaling as well as impact of
these discoveries on plant cAMP research in general.
acknowledgement: 'We gratefully acknowledge our brave colleagues, whose excellent
efforts kept the plant cAMP research going in the last two decades. The authors
were financially supported by the Austrian Science Fund (FWF): I 6123 and P 37051-B.'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Linlin
full_name: Qi, Linlin
id: 44B04502-A9ED-11E9-B6FC-583AE6697425
last_name: Qi
orcid: 0000-0001-5187-8401
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Qi L, Friml J. Tale of cAMP as a second messenger in auxin signaling and beyond.
New Phytologist. 2023;240(2):489-495. doi:10.1111/nph.19123
apa: Qi, L., & Friml, J. (2023). Tale of cAMP as a second messenger in auxin
signaling and beyond. New Phytologist. Wiley. https://doi.org/10.1111/nph.19123
chicago: Qi, Linlin, and Jiří Friml. “Tale of CAMP as a Second Messenger in Auxin
Signaling and Beyond.” New Phytologist. Wiley, 2023. https://doi.org/10.1111/nph.19123.
ieee: L. Qi and J. Friml, “Tale of cAMP as a second messenger in auxin signaling
and beyond,” New Phytologist, vol. 240, no. 2. Wiley, pp. 489–495, 2023.
ista: Qi L, Friml J. 2023. Tale of cAMP as a second messenger in auxin signaling
and beyond. New Phytologist. 240(2), 489–495.
mla: Qi, Linlin, and Jiří Friml. “Tale of CAMP as a Second Messenger in Auxin Signaling
and Beyond.” New Phytologist, vol. 240, no. 2, Wiley, 2023, pp. 489–95,
doi:10.1111/nph.19123.
short: L. Qi, J. Friml, New Phytologist 240 (2023) 489–495.
corr_author: '1'
date_created: 2023-07-23T22:01:13Z
date_published: 2023-10-01T00:00:00Z
date_updated: 2024-10-22T12:50:00Z
day: '01'
ddc:
- '580'
department:
- _id: JiFr
doi: 10.1111/nph.19123
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- '37434303'
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fulldoi: https://doi.org/10.1111/nph.19123
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intvolume: ' 240'
isi: 1
issue: '2'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
page: 489-495
pmid: 1
project:
- _id: bd76d395-d553-11ed-ba76-f678c14f9033
grant_number: I06123
name: Peptide receptors for auxin canalization in Arabidopsis
- _id: 7bcece63-9f16-11ee-852c-ae94e099eeb6
grant_number: P37051
name: Guanylate cyclase activity of TIR1/AFBs auxin receptors
publication: New Phytologist
publication_identifier:
eissn:
- 1469-8137
issn:
- 0028-646X
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Tale of cAMP as a second messenger in auxin signaling and beyond
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 240
year: '2023'
...