---
_id: '11761'
abstract:
- lang: eng
text: We prove that in an undirected graph there are at most O(n²) cuts of size
strictly less than of the size of the minimum cut.
article_processing_charge: No
article_type: original
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: David P.
full_name: Williamson, David P.
last_name: Williamson
citation:
ama: Henzinger MH, Williamson DP. On the number of small cuts in a graph. Information
Processing Letters. 1996;59(1):41-44. doi:10.1016/0020-0190(96)00079-8
apa: Henzinger, M. H., & Williamson, D. P. (1996). On the number of small cuts
in a graph. Information Processing Letters. Elsevier. https://doi.org/10.1016/0020-0190(96)00079-8
chicago: Henzinger, Monika H, and David P. Williamson. “On the Number of Small Cuts
in a Graph.” Information Processing Letters. Elsevier, 1996. https://doi.org/10.1016/0020-0190(96)00079-8.
ieee: M. H. Henzinger and D. P. Williamson, “On the number of small cuts in a graph,”
Information Processing Letters, vol. 59, no. 1. Elsevier, pp. 41–44, 1996.
ista: Henzinger MH, Williamson DP. 1996. On the number of small cuts in a graph.
Information Processing Letters. 59(1), 41–44.
mla: Henzinger, Monika H., and David P. Williamson. “On the Number of Small Cuts
in a Graph.” Information Processing Letters, vol. 59, no. 1, Elsevier,
1996, pp. 41–44, doi:10.1016/0020-0190(96)00079-8.
short: M.H. Henzinger, D.P. Williamson, Information Processing Letters 59 (1996)
41–44.
date_created: 2022-08-08T11:49:48Z
date_published: 1996-07-08T00:00:00Z
date_updated: 2022-09-12T09:39:51Z
day: '08'
doi: 10.1016/0020-0190(96)00079-8
extern: '1'
intvolume: ' 59'
issue: '1'
language:
- iso: eng
month: '07'
oa_version: None
page: 41-44
publication: Information Processing Letters
publication_identifier:
issn:
- 0020-0190
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: On the number of small cuts in a graph
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 59
year: '1996'
...
---
_id: '11804'
abstract:
- lang: eng
text: "This paper shows how a general technique, called lock-step search, used in
dynamic graph algorithms, can be used to improve the running time of two problems
arising in program verification and communication protocol design.\r\n(1)We consider
the nonemptiness problem for Streett automata: We are given a directed graph G
= (V, E) with n = ¦V¦ and m = ¦E¦, and a collection of pairs of subsets of vertices,
called Streett pairs,〈L i , U i 〉, i = 1.k. The question is whether G has a cycle
(not necessarily simple) which, for each 1 ≤ i ≤ k, if it contains a vertex from
L i then it also contains a vertex of U i . Let b=Σ i=1..k |L i |+|U i |. The
previously best algorithm takes time O((m + b) min{n, k}). We present an algorithm
that takes time \U0001D442(\U0001D45Amin{\U0001D45A\U0001D459\U0001D45C\U0001D454\U0001D45B,‾‾‾‾‾‾√\U0001D458,\U0001D45B}+\U0001D44F\U0001D45A\U0001D456\U0001D45B{\U0001D459\U0001D45C\U0001D454\U0001D45B,\U0001D458}).\r\n(2)In
communication protocol pruning we are given a directed graph G = (V, E) with l
special vertices. The problem is to efficiently maintain the strongly-connected
components of the special vertices on a restricted set of edge deletions. Let
m i be the number of edges in the strongly connected component of the ith special
vertex. The previously best algorithm repeatedly recomputes the strongly-connected
components which leads to a running time of O(Σ i m 2i). We present an algorithm
with time \U0001D442(\U0001D459√∑\U0001D456\U0001D45A1.5\U0001D456)."
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Jan Arne
full_name: Telle, Jan Arne
last_name: Telle
citation:
ama: 'Henzinger MH, Telle JA. Faster algorithms for the nonemptiness of streett
automata and for communication protocol pruning. In: 5th Scandinavian Workshop
on Algorithm Theory. Vol 1097. Springer Nature; 1996:16–27. doi:10.1007/3-540-61422-2_117'
apa: 'Henzinger, M. H., & Telle, J. A. (1996). Faster algorithms for the nonemptiness
of streett automata and for communication protocol pruning. In 5th Scandinavian
Workshop on Algorithm Theory (Vol. 1097, pp. 16–27). Reykjavik, Iceland: Springer
Nature. https://doi.org/10.1007/3-540-61422-2_117'
chicago: Henzinger, Monika H, and Jan Arne Telle. “Faster Algorithms for the Nonemptiness
of Streett Automata and for Communication Protocol Pruning.” In 5th Scandinavian
Workshop on Algorithm Theory, 1097:16–27. Springer Nature, 1996. https://doi.org/10.1007/3-540-61422-2_117.
ieee: M. H. Henzinger and J. A. Telle, “Faster algorithms for the nonemptiness of
streett automata and for communication protocol pruning,” in 5th Scandinavian
Workshop on Algorithm Theory, Reykjavik, Iceland, 1996, vol. 1097, pp. 16–27.
ista: 'Henzinger MH, Telle JA. 1996. Faster algorithms for the nonemptiness of streett
automata and for communication protocol pruning. 5th Scandinavian Workshop on
Algorithm Theory. SWAT: Scandinavian Workshop on Algorithm Theory, LNCS, vol.
1097, 16–27.'
mla: Henzinger, Monika H., and Jan Arne Telle. “Faster Algorithms for the Nonemptiness
of Streett Automata and for Communication Protocol Pruning.” 5th Scandinavian
Workshop on Algorithm Theory, vol. 1097, Springer Nature, 1996, pp. 16–27,
doi:10.1007/3-540-61422-2_117.
short: M.H. Henzinger, J.A. Telle, in:, 5th Scandinavian Workshop on Algorithm Theory,
Springer Nature, 1996, pp. 16–27.
conference:
end_date: 1996-07-05
location: Reykjavik, Iceland
name: 'SWAT: Scandinavian Workshop on Algorithm Theory'
start_date: 1996-07-03
date_created: 2022-08-11T13:42:42Z
date_published: 1996-07-01T00:00:00Z
date_updated: 2023-02-14T07:52:17Z
day: '01'
doi: 10.1007/3-540-61422-2_117
extern: '1'
intvolume: ' 1097'
language:
- iso: eng
month: '07'
oa_version: None
page: 16–27
publication: 5th Scandinavian Workshop on Algorithm Theory
publication_identifier:
eisbn:
- '9783540685296'
eissn:
- 1611-3349
isbn:
- '9783540614227'
issn:
- 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Faster algorithms for the nonemptiness of streett automata and for communication
protocol pruning
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 1097
year: '1996'
...
---
_id: '11910'
abstract:
- lang: eng
text: "We state a new sampling lemma and use it to improve the running time of dynamic
graph algorithms.\r\n\r\nFor the dynamic connectivity problem the previously best
randomized algorithm takes expected time O(log3 n) per update, amortized over
Ω(m) updates. Using the new sampling lemma, we improve its running time to O(log2
n). There exists a lower bound in the cell probe model for the time per operation
of Ω(log n/ log log n) for this problem.\r\n\r\nSimilarly improved running times
are achieved for 2-edge connectivity, k-weight minimum spanning tree, and bipartiteness."
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Mikkel
full_name: Thorup, Mikkel
last_name: Thorup
citation:
ama: 'Henzinger MH, Thorup M. Improved sampling with applications to dynamic graph
algorithms. In: 23rd International Colloquium on Automata, Languages, and Programming.
Vol 1099. Springer Nature; 1996:290-299. doi:10.1007/3-540-61440-0_136'
apa: 'Henzinger, M. H., & Thorup, M. (1996). Improved sampling with applications
to dynamic graph algorithms. In 23rd International Colloquium on Automata,
Languages, and Programming (Vol. 1099, pp. 290–299). Paderborn, Germany: Springer
Nature. https://doi.org/10.1007/3-540-61440-0_136'
chicago: Henzinger, Monika H, and Mikkel Thorup. “Improved Sampling with Applications
to Dynamic Graph Algorithms.” In 23rd International Colloquium on Automata,
Languages, and Programming, 1099:290–99. Springer Nature, 1996. https://doi.org/10.1007/3-540-61440-0_136.
ieee: M. H. Henzinger and M. Thorup, “Improved sampling with applications to dynamic
graph algorithms,” in 23rd International Colloquium on Automata, Languages,
and Programming, Paderborn, Germany, 1996, vol. 1099, pp. 290–299.
ista: 'Henzinger MH, Thorup M. 1996. Improved sampling with applications to dynamic
graph algorithms. 23rd International Colloquium on Automata, Languages, and Programming.
ICALP: International Colloquium on Automata, Languages, and Programming, LNCS,
vol. 1099, 290–299.'
mla: Henzinger, Monika H., and Mikkel Thorup. “Improved Sampling with Applications
to Dynamic Graph Algorithms.” 23rd International Colloquium on Automata, Languages,
and Programming, vol. 1099, Springer Nature, 1996, pp. 290–99, doi:10.1007/3-540-61440-0_136.
short: M.H. Henzinger, M. Thorup, in:, 23rd International Colloquium on Automata,
Languages, and Programming, Springer Nature, 1996, pp. 290–299.
conference:
end_date: 1996-07-12
location: Paderborn, Germany
name: 'ICALP: International Colloquium on Automata, Languages, and Programming'
start_date: 1996-07-08
date_created: 2022-08-18T06:42:24Z
date_published: 1996-07-01T00:00:00Z
date_updated: 2023-02-14T07:57:14Z
day: '01'
doi: 10.1007/3-540-61440-0_136
extern: '1'
intvolume: ' 1099'
language:
- iso: eng
month: '07'
oa_version: None
page: 290-299
publication: 23rd International Colloquium on Automata, Languages, and Programming
publication_identifier:
eisbn:
- '9783540685807'
eissn:
- 1611-3349
isbn:
- '9783540614401'
issn:
- 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Improved sampling with applications to dynamic graph algorithms
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 1099
year: '1996'
...
---
_id: '11927'
abstract:
- lang: eng
text: "We are given a set 7 = {Tl , Tz, . . . , Tk} of rooted binary trees, each
Ti leaf-labeled by a subset L(x) c {1,2 )...) n}. IfT is a tree on {1,2, . . ,
n}, we let T]L denote the subtree of T induced by the nodes of L and all their
ancestors. The consensus tree problem asks whether there exists a tree T* such
that for every I, T’ IC(Ti) is homeomorphic to Ti. We present algorithms which
test if a given set of trees has a consensus tree and if so, construct one. The
deterministic algorithm takes time min{O(mn’/‘), O(m + n2 logn)}, where m = Ci
IZl and uses linear space. The randomized algorithm takes\r\ntime O(m log3 n)
and uses linear space. The previous best for this problem was an 1981 O(mn) algorithm
by Aho et al. Our faster deterministic algorithm uses a new efficient algorithm
for the following interesting dynamic graph problem: Given a graph G with n nodes
and m edges and a sequence of b batches of one or more edge deletions, then after
each batch, either find a new component that has just been created or determine
that there is no such component. For this\r\nproblem, we have a simple algorithm
with running time O(n2 log n + be min{ n2, m log n}), where be is the number of
batches which do not result in a new component. For our particular application,
bc 5 1. If all edges are deleted, then the best previously known deterministic
algorithm requires time O(mJ;ii) to solve this problem. computational evolutionary
biology. The first application is in the problem of inferring consensus of trees
when there can be disagreement[l6]. There have, been several models suggested
for this problem[2, 3, 4, 8, ?, 11, 17, 181, of which one is called the Local
Consensus Tree[l5]. The local consensus tree model presumes that the user provides
a local consensus rule which determines the form of the output tree on (perhaps)
each triple of leaves, and the objective is to determine whether a tree exists
which is consistent with each of the constraints. We will show that we can construct
the local consensus tree of k trees on n species in O(kn3) time, improving on
the O(lcn3 + n”) running time if we use the Aho et al algorithm. The second application
is a\r\nheuristic for constructing the maximum likelihood tree based upon combining
solutions to small subproblems.\r\nThis is a simple and yet potentially significantly
interesting approach to the evolutionary tree construction\r\nproblem. "
article_processing_charge: No
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Valerie
full_name: King, Valerie
last_name: King
- first_name: Tandy
full_name: Warnow, Tandy
last_name: Warnow
citation:
ama: 'Henzinger MH, King V, Warnow T. Constructing a tree from homeomorphic subtrees,
with applications to computational evolutionary biology. In: 7th Annual ACM-SIAM
Symposium on Discrete Algorithms. Society for Industrial and Applied Mathematics;
1996:333-340.'
apa: 'Henzinger, M. H., King, V., & Warnow, T. (1996). Constructing a tree from
homeomorphic subtrees, with applications to computational evolutionary biology.
In 7th Annual ACM-SIAM Symposium on Discrete Algorithms (pp. 333–340).
Atlanta, GA, United States: Society for Industrial and Applied Mathematics.'
chicago: Henzinger, Monika H, Valerie King, and Tandy Warnow. “Constructing a Tree
from Homeomorphic Subtrees, with Applications to Computational Evolutionary Biology.”
In 7th Annual ACM-SIAM Symposium on Discrete Algorithms, 333–40. Society
for Industrial and Applied Mathematics, 1996.
ieee: M. H. Henzinger, V. King, and T. Warnow, “Constructing a tree from homeomorphic
subtrees, with applications to computational evolutionary biology,” in 7th
Annual ACM-SIAM Symposium on Discrete Algorithms, Atlanta, GA, United States,
1996, pp. 333–340.
ista: 'Henzinger MH, King V, Warnow T. 1996. Constructing a tree from homeomorphic
subtrees, with applications to computational evolutionary biology. 7th Annual
ACM-SIAM Symposium on Discrete Algorithms. SODA: Symposium on Discrete Algorithms,
333–340.'
mla: Henzinger, Monika H., et al. “Constructing a Tree from Homeomorphic Subtrees,
with Applications to Computational Evolutionary Biology.” 7th Annual ACM-SIAM
Symposium on Discrete Algorithms, Society for Industrial and Applied Mathematics,
1996, pp. 333–40.
short: M.H. Henzinger, V. King, T. Warnow, in:, 7th Annual ACM-SIAM Symposium on
Discrete Algorithms, Society for Industrial and Applied Mathematics, 1996, pp.
333–340.
conference:
end_date: 1996-01-30
location: Atlanta, GA, United States
name: 'SODA: Symposium on Discrete Algorithms'
start_date: 1996-01-28
date_created: 2022-08-19T06:57:47Z
date_published: 1996-01-28T00:00:00Z
date_updated: 2023-02-21T16:24:53Z
day: '28'
extern: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://dl.acm.org/doi/10.5555/313852.314080
month: '01'
oa: 1
oa_version: Published Version
page: 333 -340
publication: 7th Annual ACM-SIAM Symposium on Discrete Algorithms
publication_identifier:
isbn:
- '0898713668'
publication_status: published
publisher: Society for Industrial and Applied Mathematics
quality_controlled: '1'
related_material:
record:
- id: '11679'
relation: later_version
status: public
scopus_import: '1'
status: public
title: Constructing a tree from homeomorphic subtrees, with applications to computational
evolutionary biology
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '1996'
...
---
_id: '1942'
alternative_title:
- 'Photosynthesis: from light to biosphere'
author:
- first_name: Leonid A
full_name: Leonid Sazanov
id: 338D39FE-F248-11E8-B48F-1D18A9856A87
last_name: Sazanov
orcid: 0000-0002-0977-7989
- first_name: P
full_name: Burrows, P
last_name: Burrows
- first_name: P J
full_name: Nixon, P J
last_name: Nixon
citation:
ama: 'Sazanov LA, Burrows P, Nixon PJ. Presence of a large protein complex containing
the ndhK gene product and possessing NADH-specific dehydrogenase activity in thylakoid
membranes of higher plant chloroplasts. In: Vol 2. Kluwer; 1996:705-708.'
apa: 'Sazanov, L. A., Burrows, P., & Nixon, P. J. (1996). Presence of a large
protein complex containing the ndhK gene product and possessing NADH-specific
dehydrogenase activity in thylakoid membranes of higher plant chloroplasts (Vol.
2, pp. 705–708). Presented at the IPC: International Photosynthesis Congress,
Kluwer.'
chicago: Sazanov, Leonid A, P Burrows, and P J Nixon. “Presence of a Large Protein
Complex Containing the NdhK Gene Product and Possessing NADH-Specific Dehydrogenase
Activity in Thylakoid Membranes of Higher Plant Chloroplasts,” 2:705–8. Kluwer,
1996.
ieee: 'L. A. Sazanov, P. Burrows, and P. J. Nixon, “Presence of a large protein
complex containing the ndhK gene product and possessing NADH-specific dehydrogenase
activity in thylakoid membranes of higher plant chloroplasts,” presented at the
IPC: International Photosynthesis Congress, 1996, vol. 2, pp. 705–708.'
ista: 'Sazanov LA, Burrows P, Nixon PJ. 1996. Presence of a large protein complex
containing the ndhK gene product and possessing NADH-specific dehydrogenase activity
in thylakoid membranes of higher plant chloroplasts. IPC: International Photosynthesis
Congress, Photosynthesis: from light to biosphere, vol. 2, 705–708.'
mla: Sazanov, Leonid A., et al. Presence of a Large Protein Complex Containing
the NdhK Gene Product and Possessing NADH-Specific Dehydrogenase Activity in Thylakoid
Membranes of Higher Plant Chloroplasts. Vol. 2, Kluwer, 1996, pp. 705–08.
short: L.A. Sazanov, P. Burrows, P.J. Nixon, in:, Kluwer, 1996, pp. 705–708.
conference:
name: 'IPC: International Photosynthesis Congress'
date_created: 2018-12-11T11:54:50Z
date_published: 1996-01-01T00:00:00Z
date_updated: 2021-01-12T06:54:14Z
day: '01'
extern: 1
intvolume: ' 2'
month: '01'
page: 705 - 708
publication_status: published
publisher: Kluwer
publist_id: '5143'
quality_controlled: 0
status: public
title: Presence of a large protein complex containing the ndhK gene product and possessing
NADH-specific dehydrogenase activity in thylakoid membranes of higher plant chloroplasts
type: conference
volume: 2
year: '1996'
...
---
_id: '1952'
abstract:
- lang: eng
text: Two strains of Rhodospirillum rubrum were constructed in which, by a gene
dosage effect, the transhydrogenase activity of isolated chromatophores was increased
7-10-fold and 15-20-fold, respectively. The H+/H- ratio (the ratio of protons
translocated per hydride ion equivalent transferred from NADPH to an NAD+ analogue,
acetyl pyridine adenine dinucleotide), determined by a spectroscopic technique,
was approximately 1.0 for chromatophores from the over-expressing strains, but
was only approximately 0.6 for wild-type chromatophores. Highly-coupled proteoliposomes
were prepared containing purified transhydrogenase from beef-heart mitochondria.
Using the same technique, the H+/H- ratio was close to 1.0 for these proteoliposomes.
It is suggested that the mechanistic H+/H- ratio is indeed unity, but that a low
ratio is obtained in wild-type chromatophores because of inhomogeneity in the
vesicle population.
acknowledgement: L.A.S. would like to thank the Wellcome Trust, and T.B., the Biotechnology
and Biological Sciences Research Council, for financial support. We are very grateful
to Nick Cotton for helpful advice.
article_processing_charge: No
article_type: original
author:
- first_name: Tania
full_name: Bizouarn, Tania
last_name: Bizouarn
- first_name: Leonid A
full_name: Sazanov, Leonid A
id: 338D39FE-F248-11E8-B48F-1D18A9856A87
last_name: Sazanov
orcid: 0000-0002-0977-7989
- first_name: Sébastien
full_name: Aubourg, Sébastien
last_name: Aubourg
- first_name: Julie
full_name: Jackson, Julie
last_name: Jackson
citation:
ama: Bizouarn T, Sazanov LA, Aubourg S, Jackson J. Estimation of the H+/H- ratio
of the reaction catalysed by the nicotinamide nucleotide transhydrogenase in chromatophores
from over-expressing strains of Rhodospirillum rubrum and in liposomes inlaid
with the purified bovine enzyme. Biochimica et Biophysica Acta - Bioenergetics.
1996;1273(1):4-12. doi:10.1016/0005-2728(95)00125-5
apa: Bizouarn, T., Sazanov, L. A., Aubourg, S., & Jackson, J. (1996). Estimation
of the H+/H- ratio of the reaction catalysed by the nicotinamide nucleotide transhydrogenase
in chromatophores from over-expressing strains of Rhodospirillum rubrum and in
liposomes inlaid with the purified bovine enzyme. Biochimica et Biophysica
Acta - Bioenergetics. Elsevier. https://doi.org/10.1016/0005-2728(95)00125-5
chicago: Bizouarn, Tania, Leonid A Sazanov, Sébastien Aubourg, and Julie Jackson.
“Estimation of the H+/H- Ratio of the Reaction Catalysed by the Nicotinamide Nucleotide
Transhydrogenase in Chromatophores from over-Expressing Strains of Rhodospirillum
Rubrum and in Liposomes Inlaid with the Purified Bovine Enzyme.” Biochimica
et Biophysica Acta - Bioenergetics. Elsevier, 1996. https://doi.org/10.1016/0005-2728(95)00125-5.
ieee: T. Bizouarn, L. A. Sazanov, S. Aubourg, and J. Jackson, “Estimation of the
H+/H- ratio of the reaction catalysed by the nicotinamide nucleotide transhydrogenase
in chromatophores from over-expressing strains of Rhodospirillum rubrum and in
liposomes inlaid with the purified bovine enzyme,” Biochimica et Biophysica
Acta - Bioenergetics, vol. 1273, no. 1. Elsevier, pp. 4–12, 1996.
ista: Bizouarn T, Sazanov LA, Aubourg S, Jackson J. 1996. Estimation of the H+/H-
ratio of the reaction catalysed by the nicotinamide nucleotide transhydrogenase
in chromatophores from over-expressing strains of Rhodospirillum rubrum and in
liposomes inlaid with the purified bovine enzyme. Biochimica et Biophysica Acta
- Bioenergetics. 1273(1), 4–12.
mla: Bizouarn, Tania, et al. “Estimation of the H+/H- Ratio of the Reaction Catalysed
by the Nicotinamide Nucleotide Transhydrogenase in Chromatophores from over-Expressing
Strains of Rhodospirillum Rubrum and in Liposomes Inlaid with the Purified Bovine
Enzyme.” Biochimica et Biophysica Acta - Bioenergetics, vol. 1273, no.
1, Elsevier, 1996, pp. 4–12, doi:10.1016/0005-2728(95)00125-5.
short: T. Bizouarn, L.A. Sazanov, S. Aubourg, J. Jackson, Biochimica et Biophysica
Acta - Bioenergetics 1273 (1996) 4–12.
date_created: 2018-12-11T11:54:53Z
date_published: 1996-01-11T00:00:00Z
date_updated: 2022-08-16T12:35:22Z
day: '11'
doi: 10.1016/0005-2728(95)00125-5
extern: '1'
external_id:
pmid:
- '8573594 '
intvolume: ' 1273'
issue: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 4 - 12
pmid: 1
publication: Biochimica et Biophysica Acta - Bioenergetics
publication_identifier:
issn:
- 0005-2728
publication_status: published
publisher: Elsevier
publist_id: '5132'
quality_controlled: '1'
status: public
title: Estimation of the H+/H- ratio of the reaction catalysed by the nicotinamide
nucleotide transhydrogenase in chromatophores from over-expressing strains of Rhodospirillum
rubrum and in liposomes inlaid with the purified bovine enzyme
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1273
year: '1996'
...
---
_id: '1951'
article_processing_charge: No
article_type: original
author:
- first_name: Leonid A
full_name: Sazanov, Leonid A
id: 338D39FE-F248-11E8-B48F-1D18A9856A87
last_name: Sazanov
orcid: 0000-0002-0977-7989
- first_name: Paul
full_name: Burrows, Paul
last_name: Burrows
- first_name: Peter
full_name: Nixon, Peter
last_name: Nixon
citation:
ama: Sazanov LA, Burrows P, Nixon P. Detection and characterization of a complex
I-like NADH-specific dehydrogenase from pea thylakoids. Biochemical Society
Transactions. 1996;24(3):739-743. doi:10.1042/bst0240739
apa: Sazanov, L. A., Burrows, P., & Nixon, P. (1996). Detection and characterization
of a complex I-like NADH-specific dehydrogenase from pea thylakoids. Biochemical
Society Transactions. Portland Press. https://doi.org/10.1042/bst0240739
chicago: Sazanov, Leonid A, Paul Burrows, and Peter Nixon. “Detection and Characterization
of a Complex I-like NADH-Specific Dehydrogenase from Pea Thylakoids.” Biochemical
Society Transactions. Portland Press, 1996. https://doi.org/10.1042/bst0240739.
ieee: L. A. Sazanov, P. Burrows, and P. Nixon, “Detection and characterization of
a complex I-like NADH-specific dehydrogenase from pea thylakoids,” Biochemical
Society Transactions, vol. 24, no. 3. Portland Press, pp. 739–743, 1996.
ista: Sazanov LA, Burrows P, Nixon P. 1996. Detection and characterization of a
complex I-like NADH-specific dehydrogenase from pea thylakoids. Biochemical Society
Transactions. 24(3), 739–743.
mla: Sazanov, Leonid A., et al. “Detection and Characterization of a Complex I-like
NADH-Specific Dehydrogenase from Pea Thylakoids.” Biochemical Society Transactions,
vol. 24, no. 3, Portland Press, 1996, pp. 739–43, doi:10.1042/bst0240739.
short: L.A. Sazanov, P. Burrows, P. Nixon, Biochemical Society Transactions 24 (1996)
739–743.
date_created: 2018-12-11T11:54:53Z
date_published: 1996-01-01T00:00:00Z
date_updated: 2022-08-16T08:25:02Z
day: '01'
doi: 10.1042/bst0240739
extern: '1'
external_id:
pmid:
- '8878837'
intvolume: ' 24'
issue: '3'
language:
- iso: eng
month: '01'
oa_version: None
page: 739 - 743
pmid: 1
publication: Biochemical Society Transactions
publication_identifier:
issn:
- 0300-5127
publication_status: published
publisher: Portland Press
publist_id: '5131'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Detection and characterization of a complex I-like NADH-specific dehydrogenase
from pea thylakoids
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 24
year: '1996'
...
---
_id: '2492'
abstract:
- lang: eng
text: The metabotropic glutamate receptor subtypes mGluR2 and mGluR5, which are
thought to be coupled respectively to the inhibitory cyclic adenosine monophosphate
(cAMP) cascade and the phosphatidylinositol hydrolysis/Ca2+ cascade, are known
to be expressed on Golgi cells in the granular layer of the rat cerebellar cortex.
In the present immunohistochemical study with a monoclonal antibody against mGluR2
and a polyclonal antibody for mGluR5, we examined whether or not mGluR2- and mGluR5-like
immunoreactivities were both present in single Golgi cells in the rat cerebellar
cortex. In double immunofluorescence histochemistry, no Golgi cells showed mGluR2-
and mGluR5-like immunoreactivities simultaneously. Of the total number of Golgi
cells immunoreactive for mGluR2 or mGluR5, about 90% were mGluR2-like immunoreactive,
and about 10% were mGluR5-like immunoreactive. Golgi cells with mGluR2-like immunoreactivity
were distributed evenly in the granular layer of all the cerebellar regions, while
those with mGluR5-like immunoreactivity were distributed more frequently in the
I, II, VII-X lobules of the vermis and the copula pyramidis of the hemisphere
than in other cerebellar regions. The results indicate that Golgi cells containing
mGluR2 are segregated from those possessing mGluR5. These two populations of Golgi
cells, each equipped with a different metabolic glutamate receptor coupled to
a different intracellular signal transduction system, may play different roles
in the glutamatergic neuronal circuits in the cerebellar cortex.
acknowledgement: We thank Mr Akira Uesugi for expert photographic assistance. We also
thank Dr Jeremy M. Henley for a critical reading of the manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Akio
full_name: Neki, Akio
last_name: Neki
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Takeshi
full_name: Kaneko, Takeshi
last_name: Kaneko
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Neki A, Ohishi H, Kaneko T, Shigemoto R, Nakanishi S, Mizuno N. Metabotropic
glutamate receptors mGluR2 and mGluR5 are expressed in two non-overlapping populations
of Golgi cells in the rat cerebellum. Neuroscience. 1996;75(3):815-826.
doi:10.1016/0306-4522(96)00316-8
apa: Neki, A., Ohishi, H., Kaneko, T., Shigemoto, R., Nakanishi, S., & Mizuno,
N. (1996). Metabotropic glutamate receptors mGluR2 and mGluR5 are expressed in
two non-overlapping populations of Golgi cells in the rat cerebellum. Neuroscience.
Elsevier. https://doi.org/10.1016/0306-4522(96)00316-8
chicago: Neki, Akio, Hitoshi Ohishi, Takeshi Kaneko, Ryuichi Shigemoto, Shigetada
Nakanishi, and Noboru Mizuno. “Metabotropic Glutamate Receptors MGluR2 and MGluR5
Are Expressed in Two Non-Overlapping Populations of Golgi Cells in the Rat Cerebellum.”
Neuroscience. Elsevier, 1996. https://doi.org/10.1016/0306-4522(96)00316-8.
ieee: A. Neki, H. Ohishi, T. Kaneko, R. Shigemoto, S. Nakanishi, and N. Mizuno,
“Metabotropic glutamate receptors mGluR2 and mGluR5 are expressed in two non-overlapping
populations of Golgi cells in the rat cerebellum,” Neuroscience, vol. 75,
no. 3. Elsevier, pp. 815–826, 1996.
ista: Neki A, Ohishi H, Kaneko T, Shigemoto R, Nakanishi S, Mizuno N. 1996. Metabotropic
glutamate receptors mGluR2 and mGluR5 are expressed in two non-overlapping populations
of Golgi cells in the rat cerebellum. Neuroscience. 75(3), 815–826.
mla: Neki, Akio, et al. “Metabotropic Glutamate Receptors MGluR2 and MGluR5 Are
Expressed in Two Non-Overlapping Populations of Golgi Cells in the Rat Cerebellum.”
Neuroscience, vol. 75, no. 3, Elsevier, 1996, pp. 815–26, doi:10.1016/0306-4522(96)00316-8.
short: A. Neki, H. Ohishi, T. Kaneko, R. Shigemoto, S. Nakanishi, N. Mizuno, Neuroscience
75 (1996) 815–826.
date_created: 2018-12-11T11:57:59Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-12T12:11:03Z
day: '01'
doi: 10.1016/0306-4522(96)00316-8
extern: '1'
external_id:
pmid:
- '8951875'
intvolume: ' 75'
issue: '3'
language:
- iso: eng
month: '12'
oa_version: None
page: 815 - 826
pmid: 1
publication: Neuroscience
publication_identifier:
issn:
- 0306-4522
publication_status: published
publisher: Elsevier
publist_id: '4409'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Metabotropic glutamate receptors mGluR2 and mGluR5 are expressed in two non-overlapping
populations of Golgi cells in the rat cerebellum
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 75
year: '1996'
...
---
_id: '2564'
abstract:
- lang: eng
text: The distribution of the neuromedin K receptor (NK3; NKR) in the central nervous
system was investigated in the adult rat by using in situ hybridization and immunohistochemical
techniques. The rabbit anti-NKR antibody was raised against a bacterial fusion
protein containing a C- terminal portion of NKR and affinity purified with a Sepharose
4B column conjugated to the fusion protein. Immunoblot analysis was performed
to test the reactivity and specificity of the antibody. Crude membrane was prepared
from cDNA-transfected Chinese hamster ovary (CHO) cells expressing each of the
rat NKR, substance P receptor (NK1; SPR), and substance K receptor (NK2; SKR)
and from the hypothalamus, cerebral cortex, and cerebellum. Immunoreactive bands
were observed specifically in the NKR-CHO cells, hypothalamus, and cerebral cortex
but not in the SPR- or SKR-CHO cells, nor in the cerebellum. Molecular weights
of the immunoreactive bands ranged from 73 to 89 kDa and from 59 to 83 kDa in
the NKR-CHO cells and tissues, respectively. The distribution of NKR-like immunoreactivity
coincided with that of NKR mRNA. The expression of NKR was indicated on neuronal
cell bodies and dendrites. NKR was found to be expressed intensely or moderately
in neurons in the glomerular and granule cell layers of the main olfactory bulb;
glomerular and mitral cell layers of the accessory olfactory bulb; layers IV and
V of the cerebral neocortex; medial septal nucleus; nucleus of the diagonal band;
bed nucleus of the stria terminalis; globus pallidus; ventral pallidum; paraventricular
nucleus; supraoptic nucleus; zona incerta; dorsal, lateral, and posterior hypothalamic
areas; amygdaloid nuclei; medial habenular nucleus; ventral tegmental area; midbrain
periaqueductal gray; interpeduncular nuclei; substantia nigra pars compacta; linear,
median, dorsal, and pontine raphe nuclei; posteromedial tegmental nucleus; sphenoid
nucleus; nucleus of the solitary tract; intermediate and rostroventrolateral reticular
nuclei; and lamina II of the caudal spinal trigeminal nucleus and spinal dorsal
horn. These findings are discussed in relation to the physiological functions
associated with neuromedin K.
acknowledgement: 'We are grateful for the photographic help of Mr. A. Uesugi and
the support of Drs. Satoru Fukuchi, Ritsu Hayashi, Sozaburo Hayashi, Mizuho Katsurada,
Yutaka Kitani, Keiko Kumagai, Toshihiko Kuroda, Hiroshi Matsu- bara, Hiroshi Matsushima, Chisato
Minakuchi, Gonpei Niwa, Hajime Oda, Masahiko Ohbayashi, Sei-ichi Ohbayashi,
Hiroyasu Ohtsuka, Shigeo Tamaki, Eizo Watanabe, Kazuo Yoshino, and Toshiaki Yoshino.
This work was supported in part by Grants-in-Aid for Special Research on Priority
areas 05267104, Scientific Research (B) 05454658, and Scientific Research (C) 06680735
from the Ministry of Education, Science and Culture of Japan. '
article_processing_charge: No
article_type: original
author:
- first_name: Yu
full_name: Ding, Yu
last_name: Ding
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Masahiko
full_name: Takada, Masahiko
last_name: Takada
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Ding Y, Shigemoto R, Takada M, Ohishi H, Nakanishi S, Mizuno N. Localization
of the neuromedin K receptor (NK3) in the central nervous system of the rat. Journal
of Comparative Neurology. 1996;364(2):290-310. doi:10.1002/(SICI)1096-9861(19960108)364:2<290::AID-CNE8>3.0.CO;2-0
apa: Ding, Y., Shigemoto, R., Takada, M., Ohishi, H., Nakanishi, S., & Mizuno,
N. (1996). Localization of the neuromedin K receptor (NK3) in the central nervous
system of the rat. Journal of Comparative Neurology. Wiley-Blackwell. https://doi.org/10.1002/(SICI)1096-9861(19960108)364:2<290::AID-CNE8>3.0.CO;2-0
chicago: Ding, Yu, Ryuichi Shigemoto, Masahiko Takada, Hitoshi Ohishi, Shigetada
Nakanishi, and Noboru Mizuno. “Localization of the Neuromedin K Receptor (NK3)
in the Central Nervous System of the Rat.” Journal of Comparative Neurology.
Wiley-Blackwell, 1996. https://doi.org/10.1002/(SICI)1096-9861(19960108)364:2<290::AID-CNE8>3.0.CO;2-0.
ieee: Y. Ding, R. Shigemoto, M. Takada, H. Ohishi, S. Nakanishi, and N. Mizuno,
“Localization of the neuromedin K receptor (NK3) in the central nervous system
of the rat,” Journal of Comparative Neurology, vol. 364, no. 2. Wiley-Blackwell,
pp. 290–310, 1996.
ista: Ding Y, Shigemoto R, Takada M, Ohishi H, Nakanishi S, Mizuno N. 1996. Localization
of the neuromedin K receptor (NK3) in the central nervous system of the rat. Journal
of Comparative Neurology. 364(2), 290–310.
mla: Ding, Yu, et al. “Localization of the Neuromedin K Receptor (NK3) in the Central
Nervous System of the Rat.” Journal of Comparative Neurology, vol. 364,
no. 2, Wiley-Blackwell, 1996, pp. 290–310, doi:10.1002/(SICI)1096-9861(19960108)364:2<290::AID-CNE8>3.0.CO;2-0.
short: Y. Ding, R. Shigemoto, M. Takada, H. Ohishi, S. Nakanishi, N. Mizuno, Journal
of Comparative Neurology 364 (1996) 290–310.
date_created: 2018-12-11T11:58:25Z
date_published: 1996-01-08T00:00:00Z
date_updated: 2022-08-12T09:48:24Z
day: '08'
doi: 10.1002/(SICI)1096-9861(19960108)364:2<290::AID-CNE8>3.0.CO;2-0
extern: '1'
external_id:
pmid:
- '8788251 '
intvolume: ' 364'
issue: '2'
language:
- iso: eng
month: '01'
oa_version: None
page: 290 - 310
pmid: 1
publication: Journal of Comparative Neurology
publication_identifier:
issn:
- 0021-9967
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4334'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Localization of the neuromedin K receptor (NK3) in the central nervous system
of the rat
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 364
year: '1996'
...
---
_id: '2566'
abstract:
- lang: eng
text: The present study indicated presynaptic localization of a metabotropic glutamate
receptor, mGluR8, in projection neurons of the main olfactory bulb of rat. An
antibody was produced by using a peptide corresponding to C-terminal 23 amino
acids of mouse mGluR8. It was confirmed that the C-terminal 23 amino acids of
rat mGluR8 were the same as those of mouse mGluR8 except for one, and that the
antibody specifically recognized mGluR8 in the rat rhinencephalon. In layer Ia
of the piriform cortex (a target area of projection fibers from the main olfactory
bulb), mGluR8-like immunoreactivity (mGluR8-LI) was reduced after transection
of the lateral olfactory tract, and mGluR8-LI was observed in axon terminals which
were filled with round synaptic vesicles and made asymmetric synapses with dendritic
spines.
acknowledgement: 'We are grateful to Mr. Akira Uesugi for photographic help, and to
Dr. Toshikazu Fukui, Dainippon Pharmaceutical Co. Ltd. [k)r technical assistance. '
article_processing_charge: No
article_type: original
author:
- first_name: Ayae
full_name: Kinoshita, Ayae
last_name: Kinoshita
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Akio
full_name: Neki, Akio
last_name: Neki
- first_name: Sakashi
full_name: Nomura, Sakashi
last_name: Nomura
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Masahiko
full_name: Takada, Masahiko
last_name: Takada
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: 'Kinoshita A, Ohishi H, Neki A, et al. Presynaptic localization of a metabotropic
glutamate receptor, mGluR8, in the rhinencephalic areas: A light and electron
microscope study in the rat. Neuroscience Letters. 1996;207(1):61-64. doi:10.1016/0304-3940(96)12489-7'
apa: 'Kinoshita, A., Ohishi, H., Neki, A., Nomura, S., Shigemoto, R., Takada, M.,
… Mizuno, N. (1996). Presynaptic localization of a metabotropic glutamate receptor,
mGluR8, in the rhinencephalic areas: A light and electron microscope study in
the rat. Neuroscience Letters. Elsevier. https://doi.org/10.1016/0304-3940(96)12489-7'
chicago: 'Kinoshita, Ayae, Hitoshi Ohishi, Akio Neki, Sakashi Nomura, Ryuichi Shigemoto,
Masahiko Takada, Shigetada Nakanishi, and Noboru Mizuno. “Presynaptic Localization
of a Metabotropic Glutamate Receptor, MGluR8, in the Rhinencephalic Areas: A Light
and Electron Microscope Study in the Rat.” Neuroscience Letters. Elsevier,
1996. https://doi.org/10.1016/0304-3940(96)12489-7.'
ieee: 'A. Kinoshita et al., “Presynaptic localization of a metabotropic glutamate
receptor, mGluR8, in the rhinencephalic areas: A light and electron microscope
study in the rat,” Neuroscience Letters, vol. 207, no. 1. Elsevier, pp.
61–64, 1996.'
ista: 'Kinoshita A, Ohishi H, Neki A, Nomura S, Shigemoto R, Takada M, Nakanishi
S, Mizuno N. 1996. Presynaptic localization of a metabotropic glutamate receptor,
mGluR8, in the rhinencephalic areas: A light and electron microscope study in
the rat. Neuroscience Letters. 207(1), 61–64.'
mla: 'Kinoshita, Ayae, et al. “Presynaptic Localization of a Metabotropic Glutamate
Receptor, MGluR8, in the Rhinencephalic Areas: A Light and Electron Microscope
Study in the Rat.” Neuroscience Letters, vol. 207, no. 1, Elsevier, 1996,
pp. 61–64, doi:10.1016/0304-3940(96)12489-7.'
short: A. Kinoshita, H. Ohishi, A. Neki, S. Nomura, R. Shigemoto, M. Takada, S.
Nakanishi, N. Mizuno, Neuroscience Letters 207 (1996) 61–64.
date_created: 2018-12-11T11:58:25Z
date_published: 1996-03-22T00:00:00Z
date_updated: 2022-08-12T09:24:06Z
day: '22'
doi: 10.1016/0304-3940(96)12489-7
extern: '1'
external_id:
pmid:
- '8710211 '
intvolume: ' 207'
issue: '1'
language:
- iso: eng
month: '03'
oa_version: None
page: 61 - 64
pmid: 1
publication: Neuroscience Letters
publication_identifier:
issn:
- 0304-3940
publication_status: published
publisher: Elsevier
publist_id: '4332'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Presynaptic localization of a metabotropic glutamate receptor, mGluR8, in
the rhinencephalic areas: A light and electron microscope study in the rat'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 207
year: '1996'
...
---
_id: '2565'
abstract:
- lang: eng
text: Immunoreactivity for the metabotropic glutamate receptor 7 (mGluR7) and that
for phosphate-activated glutaminase (PAG) were examined in the trigeminal (TG),
dorsal root (DRG), nodose (NG), superior cervical, celiac, and pelvic ganglia
of the rat. Virtually all neuronal cell bodies showed mGluR7-like immunoreactivity
(mGluR7-LI) in these ganglia. On the other hand, PAG-like immunoreactivity (PAG)
was seen in almost all neuronal cell bodies in the TG, DRG and NG, but not in
the other ganglia. Co-existence of mGluR7- and PAG-LI in the TG, DRG and NG was
confirmed by a double-immunofluorescence immunohistochemical method. The results
indicate that virtually all sensory ganglion neurons are glutamatergic and equipped
with mGluR7.
acknowledgement: The authors are grateful for the support of Dr. Kajitaro Morita and
photographic help of Mr. Akira Uesugi. This work was supported in part by Grant-in-Aid
from the Ministry of Education, Science and Culture of Japan.
article_processing_charge: No
article_type: original
author:
- first_name: Jin
full_name: Li, Jin
last_name: Li
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Takeshi
full_name: Kaneko, Takeshi
last_name: Kaneko
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Akio
full_name: Neki, Akio
last_name: Neki
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Li J, Ohishi H, Kaneko T, et al. Immunohistochemical localization of a metabotropic
glutamate receptor, mGluR7, in ganglion neurons of the rat; with special reference
to the presence in glutamatergic ganglion neurons. Neuroscience Letters.
1996;204(1-2):9-12. doi:10.1016/0304-3940(95)12299-0
apa: Li, J., Ohishi, H., Kaneko, T., Shigemoto, R., Neki, A., Nakanishi, S., &
Mizuno, N. (1996). Immunohistochemical localization of a metabotropic glutamate
receptor, mGluR7, in ganglion neurons of the rat; with special reference to the
presence in glutamatergic ganglion neurons. Neuroscience Letters. Elsevier.
https://doi.org/10.1016/0304-3940(95)12299-0
chicago: Li, Jin, Hitoshi Ohishi, Takeshi Kaneko, Ryuichi Shigemoto, Akio Neki,
Shigetada Nakanishi, and Noboru Mizuno. “Immunohistochemical Localization of a
Metabotropic Glutamate Receptor, MGluR7, in Ganglion Neurons of the Rat; with
Special Reference to the Presence in Glutamatergic Ganglion Neurons.” Neuroscience
Letters. Elsevier, 1996. https://doi.org/10.1016/0304-3940(95)12299-0.
ieee: J. Li et al., “Immunohistochemical localization of a metabotropic glutamate
receptor, mGluR7, in ganglion neurons of the rat; with special reference to the
presence in glutamatergic ganglion neurons,” Neuroscience Letters, vol.
204, no. 1–2. Elsevier, pp. 9–12, 1996.
ista: Li J, Ohishi H, Kaneko T, Shigemoto R, Neki A, Nakanishi S, Mizuno N. 1996.
Immunohistochemical localization of a metabotropic glutamate receptor, mGluR7,
in ganglion neurons of the rat; with special reference to the presence in glutamatergic
ganglion neurons. Neuroscience Letters. 204(1–2), 9–12.
mla: Li, Jin, et al. “Immunohistochemical Localization of a Metabotropic Glutamate
Receptor, MGluR7, in Ganglion Neurons of the Rat; with Special Reference to the
Presence in Glutamatergic Ganglion Neurons.” Neuroscience Letters, vol.
204, no. 1–2, Elsevier, 1996, pp. 9–12, doi:10.1016/0304-3940(95)12299-0.
short: J. Li, H. Ohishi, T. Kaneko, R. Shigemoto, A. Neki, S. Nakanishi, N. Mizuno,
Neuroscience Letters 204 (1996) 9–12.
date_created: 2018-12-11T11:58:25Z
date_published: 1996-02-02T00:00:00Z
date_updated: 2022-08-12T09:29:03Z
day: '02'
doi: 10.1016/0304-3940(95)12299-0
extern: '1'
external_id:
pmid:
- '8929965 '
intvolume: ' 204'
issue: 1-2
language:
- iso: eng
month: '02'
oa_version: None
page: 9 - 12
pmid: 1
publication: Neuroscience Letters
publication_identifier:
issn:
- 0304-3940
publication_status: published
publisher: Elsevier
publist_id: '4333'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Immunohistochemical localization of a metabotropic glutamate receptor, mGluR7,
in ganglion neurons of the rat; with special reference to the presence in glutamatergic
ganglion neurons
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 204
year: '1996'
...
---
_id: '2562'
abstract:
- lang: eng
text: A monoclonal antibody against a metabotropic glutamate receptor, mGluR2, was
produced by using a glutathione S-transferase (GST) fusion protein containing
an N-terminal sequence of rat mGluR2. Intense mGluR2-like immunoreactivity (mGluR2-LI)
was seen mainly in neuropil of the cerebral cortical regions, hippocampus, olfactory
bulb, some diencephalic nuclei, dorsal cochlear nucleus and cerebellar cortex.
In the cerebellar cortex, mGluR2-LI was seen only in Golgi cells. In Ammon's hem,
mGluR2-LI was marked in the stratum lucidum of CA3 and the stratum lacunosum-moleculare
of CA1-CA3, but not detected in the stratum pyramidale. The results indicate that
mGluR2 is located not only presynaptically but also postsynaptically.
acknowledgement: We are grateful to Mr. Akira Uesugi for photographic help.
article_processing_charge: No
article_type: original
author:
- first_name: Akio
full_name: Neki, Akio
last_name: Neki
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Takeshi
full_name: Kaneko, Takeshi
last_name: Kaneko
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: 'Neki A, Ohishi H, Kaneko T, Shigemoto R, Nakanishi S, Mizuno N. Pre- and postsynaptic
localization of a metabotropic glutamate receptor, mGluR2, in the rat brain: An
immunohistochemical study with a monoclonal antibody. Neuroscience Letters.
1996;202(3):197-200. doi:10.1016/0304-3940(95)12248-6'
apa: 'Neki, A., Ohishi, H., Kaneko, T., Shigemoto, R., Nakanishi, S., & Mizuno,
N. (1996). Pre- and postsynaptic localization of a metabotropic glutamate receptor,
mGluR2, in the rat brain: An immunohistochemical study with a monoclonal antibody.
Neuroscience Letters. Elsevier. https://doi.org/10.1016/0304-3940(95)12248-6'
chicago: 'Neki, Akio, Hitoshi Ohishi, Takeshi Kaneko, Ryuichi Shigemoto, Shigetada
Nakanishi, and Noboru Mizuno. “Pre- and Postsynaptic Localization of a Metabotropic
Glutamate Receptor, MGluR2, in the Rat Brain: An Immunohistochemical Study with
a Monoclonal Antibody.” Neuroscience Letters. Elsevier, 1996. https://doi.org/10.1016/0304-3940(95)12248-6.'
ieee: 'A. Neki, H. Ohishi, T. Kaneko, R. Shigemoto, S. Nakanishi, and N. Mizuno,
“Pre- and postsynaptic localization of a metabotropic glutamate receptor, mGluR2,
in the rat brain: An immunohistochemical study with a monoclonal antibody,” Neuroscience
Letters, vol. 202, no. 3. Elsevier, pp. 197–200, 1996.'
ista: 'Neki A, Ohishi H, Kaneko T, Shigemoto R, Nakanishi S, Mizuno N. 1996. Pre-
and postsynaptic localization of a metabotropic glutamate receptor, mGluR2, in
the rat brain: An immunohistochemical study with a monoclonal antibody. Neuroscience
Letters. 202(3), 197–200.'
mla: 'Neki, Akio, et al. “Pre- and Postsynaptic Localization of a Metabotropic Glutamate
Receptor, MGluR2, in the Rat Brain: An Immunohistochemical Study with a Monoclonal
Antibody.” Neuroscience Letters, vol. 202, no. 3, Elsevier, 1996, pp. 197–200,
doi:10.1016/0304-3940(95)12248-6.'
short: A. Neki, H. Ohishi, T. Kaneko, R. Shigemoto, S. Nakanishi, N. Mizuno, Neuroscience
Letters 202 (1996) 197–200.
date_created: 2018-12-11T11:58:24Z
date_published: 1996-01-05T00:00:00Z
date_updated: 2022-08-12T12:04:18Z
day: '05'
doi: 10.1016/0304-3940(95)12248-6
extern: '1'
external_id:
pmid:
- '8848265'
intvolume: ' 202'
issue: '3'
language:
- iso: eng
month: '01'
oa_version: None
page: 197 - 200
pmid: 1
publication: Neuroscience Letters
publication_identifier:
issn:
- 0304-3940
publication_status: published
publisher: Elsevier
publist_id: '4335'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Pre- and postsynaptic localization of a metabotropic glutamate receptor, mGluR2,
in the rat brain: An immunohistochemical study with a monoclonal antibody'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 202
year: '1996'
...
---
_id: '2568'
abstract:
- lang: eng
text: Localization of a metabotropic glutamate receptor, mGluR4a, was immunohistochemically
examined in the rat cerebellum with an antibody, which was produced by using a
synthetic peptide corresponding to a C-terminal sequence of rat mGluR4a. Marked
mGluR4a-like immunoreactivity (mGluRLta-LI) was seen in neuropil of the molecular
layer of the cerebellar cortex. Electron microscopically, mGluR4a-LI was observed
in many axon terminals in the molecular layer. These axon terminals showing mGluR4a-LI
were filled with round synaptic vesicles and were in asymmetric synaptic contacts
most frequently with dendritic spines. The results indicate that mGluR4a are located
presynaptically in the parallel fibers arising from the granule cells in the cerebellar
cortex.
acknowledgement: We are grateful to Mr. Akira Uesugi for photographic help.
article_processing_charge: No
article_type: original
author:
- first_name: Ayae
full_name: Kinoshita, Ayae
last_name: Kinoshita
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Sakashi
full_name: Nomura, Sakashi
last_name: Nomura
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: 'Kinoshita A, Ohishi H, Nomura S, Shigemoto R, Nakanishi S, Mizuno N. Presynaptic
localization of a metabotropic glutamate receptor, mGluR4a, in the cerebellar
cortex: A light and electron microscope study in the rat. Neuroscience Letters.
1996;207(3):199-202. doi:10.1016/0304-3940(96)12519-2'
apa: 'Kinoshita, A., Ohishi, H., Nomura, S., Shigemoto, R., Nakanishi, S., &
Mizuno, N. (1996). Presynaptic localization of a metabotropic glutamate receptor,
mGluR4a, in the cerebellar cortex: A light and electron microscope study in the
rat. Neuroscience Letters. Elsevier. https://doi.org/10.1016/0304-3940(96)12519-2'
chicago: 'Kinoshita, Ayae, Hitoshi Ohishi, Sakashi Nomura, Ryuichi Shigemoto, Shigetada
Nakanishi, and Noboru Mizuno. “Presynaptic Localization of a Metabotropic Glutamate
Receptor, MGluR4a, in the Cerebellar Cortex: A Light and Electron Microscope Study
in the Rat.” Neuroscience Letters. Elsevier, 1996. https://doi.org/10.1016/0304-3940(96)12519-2.'
ieee: 'A. Kinoshita, H. Ohishi, S. Nomura, R. Shigemoto, S. Nakanishi, and N. Mizuno,
“Presynaptic localization of a metabotropic glutamate receptor, mGluR4a, in the
cerebellar cortex: A light and electron microscope study in the rat,” Neuroscience
Letters, vol. 207, no. 3. Elsevier, pp. 199–202, 1996.'
ista: 'Kinoshita A, Ohishi H, Nomura S, Shigemoto R, Nakanishi S, Mizuno N. 1996.
Presynaptic localization of a metabotropic glutamate receptor, mGluR4a, in the
cerebellar cortex: A light and electron microscope study in the rat. Neuroscience
Letters. 207(3), 199–202.'
mla: 'Kinoshita, Ayae, et al. “Presynaptic Localization of a Metabotropic Glutamate
Receptor, MGluR4a, in the Cerebellar Cortex: A Light and Electron Microscope Study
in the Rat.” Neuroscience Letters, vol. 207, no. 3, Elsevier, 1996, pp.
199–202, doi:10.1016/0304-3940(96)12519-2.'
short: A. Kinoshita, H. Ohishi, S. Nomura, R. Shigemoto, S. Nakanishi, N. Mizuno,
Neuroscience Letters 207 (1996) 199–202.
date_created: 2018-12-11T11:58:26Z
date_published: 1996-04-05T00:00:00Z
date_updated: 2022-08-12T09:06:18Z
day: '05'
doi: 10.1016/0304-3940(96)12519-2
extern: '1'
external_id:
pmid:
- '8728484'
intvolume: ' 207'
issue: '3'
language:
- iso: eng
month: '04'
oa_version: None
page: 199 - 202
pmid: 1
publication: Neuroscience Letters
publication_identifier:
issn:
- 0304-3940
publication_status: published
publisher: Elsevier
publist_id: '4331'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Presynaptic localization of a metabotropic glutamate receptor, mGluR4a, in
the cerebellar cortex: A light and electron microscope study in the rat'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 207
year: '1996'
...
---
_id: '2569'
abstract:
- lang: eng
text: Morphological substrates for interactions between γ-aminobutyric acid (GABA)
and substance P upon neurons expressing substance Preceptor (SPR) in the nucleus
of the solitary tract (NST) were investigated by immunocytochemical electron microscopy.
In the NST of the rat, many GABA-like immunoreactive axon terminals were in symmetric
synaptic contacts with dendritic profiles; they were observed on nearly a half
of the SPR-like immunoreactive dendritic profiles in the medial part of the caudal
half of the NST.
acknowledgement: 'The authors thank Prof. Hui-Min Li for his critical reading of the
manuscript and his excellent suggestions. We are also grateful to Ms. Miao-Li Zhang
for her assistance in the electron microscopic technique and photography and to
Mr. Akira Uesugi for photographic help. This work was supported in part by the Grant
(39370240) from the National Natural Science Foundation of China. '
article_processing_charge: No
article_type: original
author:
- first_name: Hong
full_name: Jia, Hong
last_name: Jia
- first_name: Bai
full_name: Wang, Bai
last_name: Wang
- first_name: Zhi
full_name: Rao, Zhi
last_name: Rao
- first_name: Ji
full_name: Shi, Ji
last_name: Shi
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Takeshi
full_name: Kaneko, Takeshi
last_name: Kaneko
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: 'Jia H, Wang B, Rao Z, et al. GABAergic synapses upon neurons expressing substance
P receptors in the nucleus of the solitary tract: An immunocytochemical electron
microscope study in the rat. Neuroscience Letters. 1996;210(1):49-52. doi:10.1016/0304-3940(96)12654-9'
apa: 'Jia, H., Wang, B., Rao, Z., Shi, J., Shigemoto, R., Kaneko, T., & Mizuno,
N. (1996). GABAergic synapses upon neurons expressing substance P receptors in
the nucleus of the solitary tract: An immunocytochemical electron microscope study
in the rat. Neuroscience Letters. Elsevier. https://doi.org/10.1016/0304-3940(96)12654-9'
chicago: 'Jia, Hong, Bai Wang, Zhi Rao, Ji Shi, Ryuichi Shigemoto, Takeshi Kaneko,
and Noboru Mizuno. “GABAergic Synapses upon Neurons Expressing Substance P Receptors
in the Nucleus of the Solitary Tract: An Immunocytochemical Electron Microscope
Study in the Rat.” Neuroscience Letters. Elsevier, 1996. https://doi.org/10.1016/0304-3940(96)12654-9.'
ieee: 'H. Jia et al., “GABAergic synapses upon neurons expressing substance
P receptors in the nucleus of the solitary tract: An immunocytochemical electron
microscope study in the rat,” Neuroscience Letters, vol. 210, no. 1. Elsevier,
pp. 49–52, 1996.'
ista: 'Jia H, Wang B, Rao Z, Shi J, Shigemoto R, Kaneko T, Mizuno N. 1996. GABAergic
synapses upon neurons expressing substance P receptors in the nucleus of the solitary
tract: An immunocytochemical electron microscope study in the rat. Neuroscience
Letters. 210(1), 49–52.'
mla: 'Jia, Hong, et al. “GABAergic Synapses upon Neurons Expressing Substance P
Receptors in the Nucleus of the Solitary Tract: An Immunocytochemical Electron
Microscope Study in the Rat.” Neuroscience Letters, vol. 210, no. 1, Elsevier,
1996, pp. 49–52, doi:10.1016/0304-3940(96)12654-9.'
short: H. Jia, B. Wang, Z. Rao, J. Shi, R. Shigemoto, T. Kaneko, N. Mizuno, Neuroscience
Letters 210 (1996) 49–52.
date_created: 2018-12-11T11:58:26Z
date_published: 1996-05-24T00:00:00Z
date_updated: 2022-08-12T08:18:55Z
day: '24'
doi: 10.1016/0304-3940(96)12654-9
extern: '1'
external_id:
pmid:
- '8762189'
intvolume: ' 210'
issue: '1'
language:
- iso: eng
month: '05'
oa_version: None
page: 49 - 52
pmid: 1
publication: Neuroscience Letters
publication_identifier:
issn:
- 0304-3940
publication_status: published
publisher: Elsevier
publist_id: '4329'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'GABAergic synapses upon neurons expressing substance P receptors in the nucleus
of the solitary tract: An immunocytochemical electron microscope study in the rat'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 210
year: '1996'
...
---
_id: '2567'
abstract:
- lang: eng
text: Trigeminothalamic and spinothalamic-tact neurons provided with substance P
receptor (SPR) were examined in the rat by SPR immunofluorescence histochemistry
combined with Fluoro-Gold (FG) fluorescent retrograde labeling. After FG injection
in the thalamic regions, FG-labeled cells with SPR-like immunoreactivity were
seen mainly in laminae I and m of the medullary and spinal dorsal horns and lateral
spinal nucleus. In these regions, about one-fourth to one-third of FG-labeled
cells showed SPR-like immunoreactivity.
acknowledgement: "The authors are grateful for support of Dr. Kajitaro Morita in the
Morita Clinic of Internal Medicine and Pediatrics at Kadoma, Osaka, and for photographic
help of Mr. Akira Uesugi. This work was supported in part by Grants-in-Aid from
the Ministry of Education, Science and Culture of Japan. \r\n"
article_processing_charge: No
article_type: original
author:
- first_name: Jin
full_name: Li, Jin
last_name: Li
- first_name: Yu
full_name: Ding, Yu
last_name: Ding
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Li J, Ding Y, Shigemoto R, Mizuno N. Distribution of trigeminothalamic and
spinothalamic-tract neurons showing substance P receptor-like immunoreactivity
in the rat. Brain Research. 1996;719(1-2):207-212. doi:10.1016/0006-8993(96)00064-9
apa: Li, J., Ding, Y., Shigemoto, R., & Mizuno, N. (1996). Distribution of trigeminothalamic
and spinothalamic-tract neurons showing substance P receptor-like immunoreactivity
in the rat. Brain Research. Elsevier. https://doi.org/10.1016/0006-8993(96)00064-9
chicago: Li, Jin, Yu Ding, Ryuichi Shigemoto, and Noboru Mizuno. “Distribution of
Trigeminothalamic and Spinothalamic-Tract Neurons Showing Substance P Receptor-like
Immunoreactivity in the Rat.” Brain Research. Elsevier, 1996. https://doi.org/10.1016/0006-8993(96)00064-9.
ieee: J. Li, Y. Ding, R. Shigemoto, and N. Mizuno, “Distribution of trigeminothalamic
and spinothalamic-tract neurons showing substance P receptor-like immunoreactivity
in the rat,” Brain Research, vol. 719, no. 1–2. Elsevier, pp. 207–212,
1996.
ista: Li J, Ding Y, Shigemoto R, Mizuno N. 1996. Distribution of trigeminothalamic
and spinothalamic-tract neurons showing substance P receptor-like immunoreactivity
in the rat. Brain Research. 719(1–2), 207–212.
mla: Li, Jin, et al. “Distribution of Trigeminothalamic and Spinothalamic-Tract
Neurons Showing Substance P Receptor-like Immunoreactivity in the Rat.” Brain
Research, vol. 719, no. 1–2, Elsevier, 1996, pp. 207–12, doi:10.1016/0006-8993(96)00064-9.
short: J. Li, Y. Ding, R. Shigemoto, N. Mizuno, Brain Research 719 (1996) 207–212.
date_created: 2018-12-11T11:58:26Z
date_published: 1996-05-06T00:00:00Z
date_updated: 2022-08-12T08:25:35Z
day: '06'
doi: 10.1016/0006-8993(96)00064-9
extern: '1'
external_id:
pmid:
- '8782883 '
intvolume: ' 719'
issue: 1-2
language:
- iso: eng
month: '05'
oa_version: None
page: 207 - 212
pmid: 1
publication: Brain Research
publication_identifier:
issn:
- 0006-8993
publication_status: published
publisher: Elsevier
publist_id: '4330'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Distribution of trigeminothalamic and spinothalamic-tract neurons showing substance
P receptor-like immunoreactivity in the rat
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 719
year: '1996'
...
---
_id: '2572'
abstract:
- lang: eng
text: The distribution of the mRNA for a pituitary adenylate cyclase- activating
polypeptide (PACAP) receptor (PACAP-R) was examined in the rat brain, and also
in the hypophysis and pineal gland, by in situ hybridization with a specific 35S-labeled
riboprobe which was generated from a rat PACAP-R cDNA clone. In the brain, expression
of PACAP-R mRNA was most prominent in the periglomerular and granule cells of
the olfactory bulb, granule cells of the dentate gyrus, supraoptic nucleus, and
area postrema. The expression was also intense in the piriform, cingulate, and
retrosplenial cortices, pyramidal cells in CA2, non-pyramidal cells in CA1- CA3,
neuronal cells in the hilus of the dentate gyrus, lateral septal nucleus, intercalated
amygdaloid nucleus, anterodorsal thalamic nucleus, most of the midline and intralaminar
thalamic nuclei, many regions of the hypothalamus, dorsal motor nucleus of the
vagus nerve, hypoglossal nucleus, and lateral reticular nucleus. No significant
expression was detected in the mitral and tufted cells in the olfactory bulb,
pyramidal cells in CA1 and CA3, posterior nuclear group of the thalamus, dorsal
lateral geniculate nucleus, and Purkinje, Golgi, and granule cells in the cerebellar
cortex. Moderate-to-weak expression was further observed in many other regions
of the brain. In the cerebellar cortex, presumed Bergmann gila cells showed moderate
expression. In the hypophysis, the expression was moderate in the anterior lobe,
and weak to moderate in the posterior lobe; no significant expression was observed
in the intermediate lobe. In the pineal gland, the expression was very weak, if
any. Thus, the expression of PACAP-R was detected not only on neuronal cells but
also on some particular glial cells. The present study has shown, for the first
time, the exact site of PACAP-R expression in the brain and hypophysis. Although
the functional significance of PACAP and PACAP-R in the brain still remains to
be clarified, the present results are considered to provide some direction for
future functional studies.
acknowledgement: We are grateful for the photographic help of Mr. Akira Uesugi and
helpful discussions and support of Drs. Shige- tada Nakanishi, Yukihiko Sugimoto,
Atsushi Ichikawa, Masabumi Minami, Takeshi Ishihara, Jun Ogasawara, Daisuke Watanabe,
Akiko Tani, Yoshihiro Yoshihara, Miwa Kawasaki, Hiroshi Aino, Nobuya Ogawa, Akiko
Nishino, and Rie Hosoi. We also thank Ms. Yukiko Sakagami for secretarial assistance.
This work was supported in part by a Grant-in-Aid for Scientific Research from the
Ministry of We are grateful for the photographic help of Mr. Akira Uesugi and helpful discussions
and support of Drs. Shige- tada Nakanishi, Yukihiko Sugimoto, Atsushi Ichikawa,
Masabumi Minami, Takeshi Ishihara, Jun Ogasawara, Daisuke Watanabe, Akiko Tani,
Yoshihiro Yoshihara, Miwa Kawasaki, Hiroshi Aino, Nobuya Ogawa, Akiko Nishino,
and Rie Hosoi. We also thank Ms. Yukiko Sakagami for secretarial assistance. This
work was supported in part by a Grant-in-Aid for Scientific Research from the Ministry
of We are grateful for the photographic help of Mr. Akira Uesugi and helpful discussions
and support of Drs. Shige- tada Nakanishi, Yukihiko Sugimoto, Atsushi Ichikawa,
Masabumi Minami, Takeshi Ishihara, Jun Ogasawara, Daisuke Watanabe, Akiko Tani,
Yoshihiro Yoshihara, Miwa Kawasaki, Hiroshi Aino, Nobuya Ogawa, Akiko Nishino,
and Rie Hosoi. We also thank Ms. Yukiko Sakagami for secretarial assistance. This
work was supported in part by a Grant-in-Aid for Scientific Research from the Ministry
of Education, Science and Culture of Japan and by grants from Uehara Memorial Foundation
and Ono Pharmaceutical Co., Ltd
article_processing_charge: No
article_type: original
author:
- first_name: Hitoshi
full_name: Hashimoto, Hitoshi
last_name: Hashimoto
- first_name: Hiroyuki
full_name: Nogi, Hiroyuki
last_name: Nogi
- first_name: Kensaku
full_name: Mori, Kensaku
last_name: Mori
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Kyohei
full_name: Yamamoto, Kyohei
last_name: Yamamoto
- first_name: Toshio
full_name: Matsuda, Toshio
last_name: Matsuda
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
- first_name: Shigekazu
full_name: Nagata, Shigekazu
last_name: Nagata
- first_name: Akemichi
full_name: Baba, Akemichi
last_name: Baba
citation:
ama: 'Hashimoto H, Nogi H, Mori K, et al. Distribution of the mRNA for a pituitary
adenylate cyclase-activating polypeptide receptor in the rat brain: An in situ
hybridization study. Journal of Comparative Neurology. 1996;371(4):567-577.
doi:10.1002/(SICI)1096-9861(19960805)371:4<567::AID-CNE6>3.3.CO;2-M'
apa: 'Hashimoto, H., Nogi, H., Mori, K., Ohishi, H., Shigemoto, R., Yamamoto, K.,
… Baba, A. (1996). Distribution of the mRNA for a pituitary adenylate cyclase-activating
polypeptide receptor in the rat brain: An in situ hybridization study. Journal
of Comparative Neurology. Wiley-Blackwell. https://doi.org/10.1002/(SICI)1096-9861(19960805)371:4<567::AID-CNE6>3.3.CO;2-M'
chicago: 'Hashimoto, Hitoshi, Hiroyuki Nogi, Kensaku Mori, Hitoshi Ohishi, Ryuichi
Shigemoto, Kyohei Yamamoto, Toshio Matsuda, Noboru Mizuno, Shigekazu Nagata, and
Akemichi Baba. “Distribution of the MRNA for a Pituitary Adenylate Cyclase-Activating
Polypeptide Receptor in the Rat Brain: An in Situ Hybridization Study.” Journal
of Comparative Neurology. Wiley-Blackwell, 1996. https://doi.org/10.1002/(SICI)1096-9861(19960805)371:4<567::AID-CNE6>3.3.CO;2-M.'
ieee: 'H. Hashimoto et al., “Distribution of the mRNA for a pituitary adenylate
cyclase-activating polypeptide receptor in the rat brain: An in situ hybridization
study,” Journal of Comparative Neurology, vol. 371, no. 4. Wiley-Blackwell,
pp. 567–577, 1996.'
ista: 'Hashimoto H, Nogi H, Mori K, Ohishi H, Shigemoto R, Yamamoto K, Matsuda T,
Mizuno N, Nagata S, Baba A. 1996. Distribution of the mRNA for a pituitary adenylate
cyclase-activating polypeptide receptor in the rat brain: An in situ hybridization
study. Journal of Comparative Neurology. 371(4), 567–577.'
mla: 'Hashimoto, Hitoshi, et al. “Distribution of the MRNA for a Pituitary Adenylate
Cyclase-Activating Polypeptide Receptor in the Rat Brain: An in Situ Hybridization
Study.” Journal of Comparative Neurology, vol. 371, no. 4, Wiley-Blackwell,
1996, pp. 567–77, doi:10.1002/(SICI)1096-9861(19960805)371:4<567::AID-CNE6>3.3.CO;2-M.'
short: H. Hashimoto, H. Nogi, K. Mori, H. Ohishi, R. Shigemoto, K. Yamamoto, T.
Matsuda, N. Mizuno, S. Nagata, A. Baba, Journal of Comparative Neurology 371 (1996)
567–577.
date_created: 2018-12-11T11:58:27Z
date_published: 1996-08-05T00:00:00Z
date_updated: 2022-08-11T13:20:31Z
day: '05'
doi: 10.1002/(SICI)1096-9861(19960805)371:4<567::AID-CNE6>3.3.CO;2-M
extern: '1'
external_id:
pmid:
- '8841910'
intvolume: ' 371'
issue: '4'
language:
- iso: eng
month: '08'
oa_version: None
page: 567 - 577
pmid: 1
publication: Journal of Comparative Neurology
publication_identifier:
issn:
- 0021-9967
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4326'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Distribution of the mRNA for a pituitary adenylate cyclase-activating polypeptide
receptor in the rat brain: An in situ hybridization study'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 371
year: '1996'
...
---
_id: '2574'
abstract:
- lang: eng
text: lonotropic and metabotropic (mGluR1a) glutamate receptors were reported to
be segregated from each other within the postsynaptic membrane at individual synapses.
In order to establish whether this pattern of distribution applies to the hippocampal
principal cells and to other postsynaptic metabotropic glutamate receptors, the
mGluR1a/b/c and mGluR5 subtypes were localized by immunocytochemistry. Principal
cells in all hippocampal fields were reactive for mGluR5, the strata oriens and
radiatum of the CA1 area being most strongly immunolabelled. Labelling for mGluR1b/c
was strongest on some pyramids in the CA3 area, weaker on granule cells and absent
on CA1 pyramids. Subpopulations of non-principal cells showed strong mGluR1 or
mGluR5 immunoreactivity. Electron microscopic pre-embedding immunoperoxidase and
both pre- and postembedding immunogold methods consistently revealed the extrasynaptic
location of both mGluRs in the somatic and dendritic membrane of pyramidal and
granule cells. The density of immunolabelling was highest on dendritic spines.
At synapses, immunoparticles for both mGluR1 and mGluR5 were found always outside
the postsynaptic membrane specializations. Receptors were particularly concentrated
in a perisynaptic annulus around type 1 synaptic junctions, including the invaginations
at 'perforated' synapses. Measurements of immunolabelling on dendritic spines
showed decreasing levels of receptor as a function of distance from the edge of
the synaptic specialization. We propose that glutamatergic synapses with an irregular
edge develop in order to increase the circumference of synaptic junctions leading
to an increase in the metabotropic to ionotropic glutamate receptor ratio at glutamate
release sites. The perisynaptic position of postsynaptic metabotropic glutamate
receptors appears to be a general feature of glutamatergic synaptic organization
and may apply to other G-protein-coupled receptors. © European Neuroscience Association.
article_processing_charge: No
article_type: original
author:
- first_name: Rafael
full_name: Luján, Rafael
last_name: Luján
- first_name: Zoltán
full_name: Nusser, Zoltán
last_name: Nusser
- first_name: John
full_name: Roberts, John
last_name: Roberts
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Péter
full_name: Somogyi, Péter
last_name: Somogyi
citation:
ama: Luján R, Nusser Z, Roberts J, Shigemoto R, Somogyi P. Perisynaptic location
of metabotropic glutamate receptors mGluR1 and mGluR5 on dendrites and dendritic
spines in the rat hippocampus. European Journal of Neuroscience. 1996;8(7):1488-1500.
doi:10.1111/j.1460-9568.1996.tb01611.x
apa: Luján, R., Nusser, Z., Roberts, J., Shigemoto, R., & Somogyi, P. (1996). Perisynaptic
location of metabotropic glutamate receptors mGluR1 and mGluR5 on dendrites and
dendritic spines in the rat hippocampus. European Journal of Neuroscience.
Wiley-Blackwell. https://doi.org/10.1111/j.1460-9568.1996.tb01611.x
chicago: Luján, Rafael, Zoltán Nusser, John Roberts, Ryuichi Shigemoto, and Péter
Somogyi. “ Perisynaptic Location of Metabotropic Glutamate Receptors MGluR1 and
MGluR5 on Dendrites and Dendritic Spines in the Rat Hippocampus.” European
Journal of Neuroscience. Wiley-Blackwell, 1996. https://doi.org/10.1111/j.1460-9568.1996.tb01611.x.
ieee: R. Luján, Z. Nusser, J. Roberts, R. Shigemoto, and P. Somogyi, “ Perisynaptic
location of metabotropic glutamate receptors mGluR1 and mGluR5 on dendrites and
dendritic spines in the rat hippocampus,” European Journal of Neuroscience,
vol. 8, no. 7. Wiley-Blackwell, pp. 1488–1500, 1996.
ista: Luján R, Nusser Z, Roberts J, Shigemoto R, Somogyi P. 1996. Perisynaptic
location of metabotropic glutamate receptors mGluR1 and mGluR5 on dendrites and
dendritic spines in the rat hippocampus. European Journal of Neuroscience. 8(7),
1488–1500.
mla: Luján, Rafael, et al. “ Perisynaptic Location of Metabotropic Glutamate Receptors
MGluR1 and MGluR5 on Dendrites and Dendritic Spines in the Rat Hippocampus.” European
Journal of Neuroscience, vol. 8, no. 7, Wiley-Blackwell, 1996, pp. 1488–500,
doi:10.1111/j.1460-9568.1996.tb01611.x.
short: R. Luján, Z. Nusser, J. Roberts, R. Shigemoto, P. Somogyi, European Journal
of Neuroscience 8 (1996) 1488–1500.
date_created: 2018-12-11T11:58:28Z
date_published: 1996-07-01T00:00:00Z
date_updated: 2022-08-11T11:57:08Z
day: '01'
doi: 10.1111/j.1460-9568.1996.tb01611.x
extern: '1'
external_id:
pmid:
- '8758956 '
intvolume: ' 8'
issue: '7'
language:
- iso: eng
month: '07'
oa_version: None
page: 1488 - 1500
pmid: 1
publication: European Journal of Neuroscience
publication_identifier:
issn:
- 0953-816X
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4324'
quality_controlled: '1'
scopus_import: '1'
status: public
title: ' Perisynaptic location of metabotropic glutamate receptors mGluR1 and mGluR5
on dendrites and dendritic spines in the rat hippocampus'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 8
year: '1996'
...
---
_id: '2573'
abstract:
- lang: eng
text: Developmental changes of the distribution pattern of substance P receptor
(SPR) were investigated immunohistochemically in the rat striatum. The SPR immunoreactivity
in the striatum first emerged at postnatal day 1 and transiently showed a patchy
pattern of distribution until it displayed the adult pattern of homogeneous distribution
by the end of the third postnatal week. The SPR-immunoreactive patches were most
marked in the medial and dorsolateral parts of the striatum, as well as in the
subcallosal streak. They matched tyrosine hydroxylase-enriched areas and, conversely,
avoided calbindin-enriched zones. No neurons within the SPR-immunoreactive patches
contained either choline acetyltransferase or somatostatin, which is known to
be contained in intrinsic neurons in the striatum. The vast majority of SPR-immunoreactive
patch neurons also contained DARPP-32, a phosphoprotein that is expressed in striatal
projection neurons with D1 dopamine receptor. The results indicate that SPR-immunoreactive
patches which appear transiently in the developing striatum are in register with
the striatal patch compartment, and that SPR immunoreactivity within these patches
may be expressed on projection neurons rather than intrinsic neurons. Such SPR
immunoreactivity in projection neurons in striatal patches may fade out in adulthood.
acknowledgement: "We thank Mr. Akira Uesugi and Ms. Miao-Li Zhang for their photographic
help. We are also grateful for the support of Dr. Kajitaro Morita in the Morita
Clinic of Internal Medicine and Pediatrics at Kadoma, Osaka, Japan, and for the
support of Drs. Satoru Fukuchi, Ritsu Hayashi, Sozaburo Hayashi, Mizuho Katsurada,
Yutaka Kitani, Keiko Kumagai, Toshihiko Kuroda., Hiroshi Matsubara, Hiroshi Matsushita,
Chisato Minakuchi, Gonpei Niwa, Hajime Oda, Masahiko Ohbayashi, Sei-ichi Ohbayashi,
Hiroyasu Ohtsuka, Shigeo Tamaki, Eizo Watanabe, Kazuo Yoshino, and Toshiaki Yoshino.
This work was supported in part by Grants-in-Aid for Special Research on Priority
Areas 05267104, Scientific Research (B) \r\n5454658, and Scientific Research (C)
05680658 and 06680735 from the Ministry of Education, Science and Culture of Japan."
article_processing_charge: No
article_type: original
author:
- first_name: Hironobu
full_name: Tokuno, Hironobu
last_name: Tokuno
- first_name: Masahiko
full_name: Takada, Masahiko
last_name: Takada
- first_name: Takeshi
full_name: Kaneko, Takeshi
last_name: Kaneko
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Tokuno H, Takada M, Kaneko T, Shigemoto R, Mizuno N. Patchy distribution of
substance P receptor immunoreactivity in the developing rat striatum. Developmental
Brain Research. 1996;95(1):107-117. doi:10.1016/0165-3806(96)00080-6
apa: Tokuno, H., Takada, M., Kaneko, T., Shigemoto, R., & Mizuno, N. (1996).
Patchy distribution of substance P receptor immunoreactivity in the developing
rat striatum. Developmental Brain Research. Elsevier. https://doi.org/10.1016/0165-3806(96)00080-6
chicago: Tokuno, Hironobu, Masahiko Takada, Takeshi Kaneko, Ryuichi Shigemoto, and
Noboru Mizuno. “Patchy Distribution of Substance P Receptor Immunoreactivity in
the Developing Rat Striatum.” Developmental Brain Research. Elsevier, 1996.
https://doi.org/10.1016/0165-3806(96)00080-6.
ieee: H. Tokuno, M. Takada, T. Kaneko, R. Shigemoto, and N. Mizuno, “Patchy distribution
of substance P receptor immunoreactivity in the developing rat striatum,” Developmental
Brain Research, vol. 95, no. 1. Elsevier, pp. 107–117, 1996.
ista: Tokuno H, Takada M, Kaneko T, Shigemoto R, Mizuno N. 1996. Patchy distribution
of substance P receptor immunoreactivity in the developing rat striatum. Developmental
Brain Research. 95(1), 107–117.
mla: Tokuno, Hironobu, et al. “Patchy Distribution of Substance P Receptor Immunoreactivity
in the Developing Rat Striatum.” Developmental Brain Research, vol. 95,
no. 1, Elsevier, 1996, pp. 107–17, doi:10.1016/0165-3806(96)00080-6.
short: H. Tokuno, M. Takada, T. Kaneko, R. Shigemoto, N. Mizuno, Developmental Brain
Research 95 (1996) 107–117.
date_created: 2018-12-11T11:58:28Z
date_published: 1996-08-20T00:00:00Z
date_updated: 2022-08-11T12:07:34Z
day: '20'
doi: 10.1016/0165-3806(96)00080-6
extern: '1'
external_id:
pmid:
- '8873981 '
intvolume: ' 95'
issue: '1'
language:
- iso: eng
month: '08'
oa_version: None
page: 107 - 117
pmid: 1
publication: Developmental Brain Research
publication_identifier:
issn:
- 0165-3806
publication_status: published
publisher: Elsevier
publist_id: '4325'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Patchy distribution of substance P receptor immunoreactivity in the developing
rat striatum
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 95
year: '1996'
...
---
_id: '2570'
abstract:
- lang: eng
text: The probability of synaptic neurotransmitter release from nerve terminals
is regulated by presynaptic receptors responding to transmitters released from
the same nerve terminal or from terminals of other neurons. The release of glutamate,
the major excitatory neurotransmitter, is suppressed by presynaptic auto receptors.
Here we show that a metabotropic glutamate receptor (mGluR7) in the rat hippocampus
is restricted to the presynaptic grid, the site of synaptic vesicle fusion. Pyramidal
cell terminals presynaptic to mGluR1α-expressing interneurons have at least a
ten-fold higher level of presynaptic mGluR7 than terminals making synapses with
pyramidal cells and other types of interneuron. Distinct levels of mGluR7 are
found at different synapses made by individual pyramidal axons or even single
boutons. These results raise the possibility that presynaptic neurons could regulate
the probability of transmitter release at individual synapses according to the
postsynaptic target
acknowledgement: 'We thank E. Molnar for help in immunoblotting; A. D. Smith for comments
on the manuscript; D. Latawiec fortechnical assistance; and P. Jays and F. Kennedy
for photographic assistance. This work was partly supported by the Ministry of Education,
Science and Culture of Japan. AK. is supported by the MHB MagyarTudomanyert Foundation
and the OTKA Foundation of the Hungarian Government. '
article_processing_charge: No
article_type: original
author:
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Ákos
full_name: Kulik, Ákos
last_name: Kulik
- first_name: John
full_name: Roberts, John
last_name: Roberts
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Zoltán
full_name: Nusser, Zoltán
last_name: Nusser
- first_name: Takeshi
full_name: Kaneko, Takeshi
last_name: Kaneko
- first_name: Péter
full_name: Somogyi, Péter
last_name: Somogyi
citation:
ama: Shigemoto R, Kulik Á, Roberts J, et al. Target-cell-specific concentration
of a metabotropic glutamate receptor in the presynaptic active zone. Nature.
1996;381(6582):523-525. doi:10.1038/381523a0
apa: Shigemoto, R., Kulik, Á., Roberts, J., Ohishi, H., Nusser, Z., Kaneko, T.,
& Somogyi, P. (1996). Target-cell-specific concentration of a metabotropic
glutamate receptor in the presynaptic active zone. Nature. Nature Publishing
Group. https://doi.org/10.1038/381523a0
chicago: Shigemoto, Ryuichi, Ákos Kulik, John Roberts, Hitoshi Ohishi, Zoltán Nusser,
Takeshi Kaneko, and Péter Somogyi. “Target-Cell-Specific Concentration of a Metabotropic
Glutamate Receptor in the Presynaptic Active Zone.” Nature. Nature Publishing
Group, 1996. https://doi.org/10.1038/381523a0.
ieee: R. Shigemoto et al., “Target-cell-specific concentration of a metabotropic
glutamate receptor in the presynaptic active zone,” Nature, vol. 381, no.
6582. Nature Publishing Group, pp. 523–525, 1996.
ista: Shigemoto R, Kulik Á, Roberts J, Ohishi H, Nusser Z, Kaneko T, Somogyi P.
1996. Target-cell-specific concentration of a metabotropic glutamate receptor
in the presynaptic active zone. Nature. 381(6582), 523–525.
mla: Shigemoto, Ryuichi, et al. “Target-Cell-Specific Concentration of a Metabotropic
Glutamate Receptor in the Presynaptic Active Zone.” Nature, vol. 381, no.
6582, Nature Publishing Group, 1996, pp. 523–25, doi:10.1038/381523a0.
short: R. Shigemoto, Á. Kulik, J. Roberts, H. Ohishi, Z. Nusser, T. Kaneko, P. Somogyi,
Nature 381 (1996) 523–525.
date_created: 2018-12-11T11:58:26Z
date_published: 1996-06-06T00:00:00Z
date_updated: 2022-08-11T14:45:35Z
day: '06'
doi: 10.1038/381523a0
extern: '1'
external_id:
pmid:
- '8632825 '
intvolume: ' 381'
issue: '6582'
language:
- iso: eng
month: '06'
oa_version: None
page: 523 - 525
pmid: 1
publication: Nature
publication_identifier:
issn:
- 0028-0836
publication_status: published
publisher: Nature Publishing Group
publist_id: '4328'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Target-cell-specific concentration of a metabotropic glutamate receptor in
the presynaptic active zone
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 381
year: '1996'
...
---
_id: '2571'
abstract:
- lang: eng
text: Subtype 2 of the metabotropic glutamate receptor (mGluR2) is expressed in
the presynaptic elements of hippocampal mossy fiber-CA3 synapses. Knockout mice
deficient in mGluR2 showed no histological changes and no alterations in basal
synaptic transmission, paired-pulse facilitation, or tetanus-induced long-term
potentiation (LTP) at the mossy fiber-CA3 synapses. Long-term depression (LTD)
induced by low-frequency stimulation, however, was almost fully abolished. The
mutant mice performed normally in water maze learning tasks. Thus, the presynaptic
mGluR2 is essential for inducing LTD at the mossy fiber-CA3 synapses, but this
hippocampal LTD does not seem to be required for spatial learning.
article_processing_charge: No
article_type: original
author:
- first_name: Mineto
full_name: Yokoi, Mineto
last_name: Yokoi
- first_name: Kazuto
full_name: Kobayashi, Kazuto
last_name: Kobayashi
- first_name: Toshiya
full_name: Manabe, Toshiya
last_name: Manabe
- first_name: Tomoyuki
full_name: Takahashi, Tomoyuki
last_name: Takahashi
- first_name: Isako
full_name: Sakaguchi, Isako
last_name: Sakaguchi
- first_name: Goro
full_name: Katsuura, Goro
last_name: Katsuura
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Sakashi
full_name: Nomura, Sakashi
last_name: Nomura
- first_name: Kenji
full_name: Nakamura, Kenji
last_name: Nakamura
- first_name: Kazuki
full_name: Nakao, Kazuki
last_name: Nakao
- first_name: Motoya
full_name: Katsuki, Motoya
last_name: Katsuki
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
citation:
ama: Yokoi M, Kobayashi K, Manabe T, et al. Impairment of hippocampal mossy fiber
LTD in mice lacking mGluR2. Science. 1996;273:645-647. doi:10.1126/science.273.5275.645
apa: Yokoi, M., Kobayashi, K., Manabe, T., Takahashi, T., Sakaguchi, I., Katsuura,
G., … Nakanishi, S. (1996). Impairment of hippocampal mossy fiber LTD in mice
lacking mGluR2. Science. American Association for the Advancement of Science.
https://doi.org/10.1126/science.273.5275.645
chicago: Yokoi, Mineto, Kazuto Kobayashi, Toshiya Manabe, Tomoyuki Takahashi, Isako
Sakaguchi, Goro Katsuura, Ryuichi Shigemoto, et al. “Impairment of Hippocampal
Mossy Fiber LTD in Mice Lacking MGluR2.” Science. American Association
for the Advancement of Science, 1996. https://doi.org/10.1126/science.273.5275.645.
ieee: M. Yokoi et al., “Impairment of hippocampal mossy fiber LTD in mice
lacking mGluR2,” Science, vol. 273. American Association for the Advancement
of Science, pp. 645–647, 1996.
ista: Yokoi M, Kobayashi K, Manabe T, Takahashi T, Sakaguchi I, Katsuura G, Shigemoto
R, Ohishi H, Nomura S, Nakamura K, Nakao K, Katsuki M, Nakanishi S. 1996. Impairment
of hippocampal mossy fiber LTD in mice lacking mGluR2. Science. 273, 645–647.
mla: Yokoi, Mineto, et al. “Impairment of Hippocampal Mossy Fiber LTD in Mice Lacking
MGluR2.” Science, vol. 273, American Association for the Advancement of
Science, 1996, pp. 645–47, doi:10.1126/science.273.5275.645.
short: M. Yokoi, K. Kobayashi, T. Manabe, T. Takahashi, I. Sakaguchi, G. Katsuura,
R. Shigemoto, H. Ohishi, S. Nomura, K. Nakamura, K. Nakao, M. Katsuki, S. Nakanishi,
Science 273 (1996) 645–647.
date_created: 2018-12-11T11:58:27Z
date_published: 1996-08-02T00:00:00Z
date_updated: 2022-08-11T13:53:55Z
day: '02'
doi: 10.1126/science.273.5275.645
extern: '1'
external_id:
pmid:
- '8662555 '
intvolume: ' 273'
language:
- iso: eng
month: '08'
oa_version: None
page: 645 - 647
pmid: 1
publication: Science
publication_identifier:
issn:
- 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '4327'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Impairment of hippocampal mossy fiber LTD in mice lacking mGluR2
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 273
year: '1996'
...
---
_id: '2726'
abstract:
- lang: eng
text: We investigate whether the eigenfunctions of the two-dimensional magnetic
Schrödinger operator have a Gaussian decay of type exp(-Cx2) at infinity (the
magnetic field is rotationally symmetric). We establish this decay if the energy
(E) of the eigenfunction is below the bottom of the essential spectrum (B), and
if the angular Fourier components of the external potential decay exponentially
(real analyticity in the angle variable). We also demonstrate that almost the
same decay is necessary. The behavior of C in the strong field limit and in the
small (B - E) limit is also studied.
acknowledgement: Partial support from the Hungarian National Foundation for Scientific
Research, grant no. 1902.
article_processing_charge: No
article_type: original
author:
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
citation:
ama: Erdös L. Gaussian decay of the magnetic eigenfunctions. Geometric and Functional
Analysis. 1996;6(2):231-248. doi:10.1007/BF02247886
apa: Erdös, L. (1996). Gaussian decay of the magnetic eigenfunctions. Geometric
and Functional Analysis. Birkhäuser. https://doi.org/10.1007/BF02247886
chicago: Erdös, László. “Gaussian Decay of the Magnetic Eigenfunctions.” Geometric
and Functional Analysis. Birkhäuser, 1996. https://doi.org/10.1007/BF02247886.
ieee: L. Erdös, “Gaussian decay of the magnetic eigenfunctions,” Geometric and
Functional Analysis, vol. 6, no. 2. Birkhäuser, pp. 231–248, 1996.
ista: Erdös L. 1996. Gaussian decay of the magnetic eigenfunctions. Geometric and
Functional Analysis. 6(2), 231–248.
mla: Erdös, László. “Gaussian Decay of the Magnetic Eigenfunctions.” Geometric
and Functional Analysis, vol. 6, no. 2, Birkhäuser, 1996, pp. 231–48, doi:10.1007/BF02247886.
short: L. Erdös, Geometric and Functional Analysis 6 (1996) 231–248.
date_created: 2018-12-11T11:59:17Z
date_published: 1996-03-01T00:00:00Z
date_updated: 2022-08-11T10:05:58Z
day: '01'
doi: 10.1007/BF02247886
extern: '1'
intvolume: ' 6'
issue: '2'
language:
- iso: eng
month: '03'
oa_version: None
page: 231 - 248
publication: Geometric and Functional Analysis
publication_identifier:
issn:
- 1016-443X
publication_status: published
publisher: Birkhäuser
publist_id: '4166'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Gaussian decay of the magnetic eigenfunctions
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 6
year: '1996'
...
---
_id: '2725'
abstract:
- lang: eng
text: We prove that the two dimensional free magnetic Schrödinger operator, with
a fixed constant magnetic field and Dirichlet boundary conditions on a planar
domain with a given area, attains its smallest possible eigenvalue if the domain
is a disk. We also give some rough bounds on the lowest magnetic eigenvalue of
the disk.
author:
- first_name: László
full_name: László Erdös
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
citation:
ama: Erdös L. Rayleigh-type isoperimetric inequality with a homogeneous magnetic
field. Calculus of Variations and Partial Differential Equations. 1996;4(3):283-292.
doi:10.1007/BF01254348
apa: Erdös, L. (1996). Rayleigh-type isoperimetric inequality with a homogeneous
magnetic field. Calculus of Variations and Partial Differential Equations.
Springer. https://doi.org/10.1007/BF01254348
chicago: Erdös, László. “Rayleigh-Type Isoperimetric Inequality with a Homogeneous
Magnetic Field.” Calculus of Variations and Partial Differential Equations.
Springer, 1996. https://doi.org/10.1007/BF01254348.
ieee: L. Erdös, “Rayleigh-type isoperimetric inequality with a homogeneous magnetic
field,” Calculus of Variations and Partial Differential Equations, vol.
4, no. 3. Springer, pp. 283–292, 1996.
ista: Erdös L. 1996. Rayleigh-type isoperimetric inequality with a homogeneous magnetic
field. Calculus of Variations and Partial Differential Equations. 4(3), 283–292.
mla: Erdös, László. “Rayleigh-Type Isoperimetric Inequality with a Homogeneous Magnetic
Field.” Calculus of Variations and Partial Differential Equations, vol.
4, no. 3, Springer, 1996, pp. 283–92, doi:10.1007/BF01254348.
short: L. Erdös, Calculus of Variations and Partial Differential Equations 4 (1996)
283–292.
date_created: 2018-12-11T11:59:16Z
date_published: 1996-04-01T00:00:00Z
date_updated: 2021-01-12T06:59:17Z
day: '01'
doi: 10.1007/BF01254348
extern: 1
intvolume: ' 4'
issue: '3'
month: '04'
page: 283 - 292
publication: Calculus of Variations and Partial Differential Equations
publication_status: published
publisher: Springer
publist_id: '4167'
quality_controlled: 0
status: public
title: Rayleigh-type isoperimetric inequality with a homogeneous magnetic field
type: journal_article
volume: 4
year: '1996'
...
---
_id: '3553'
abstract:
- lang: eng
text: Virtual environments open up new opportunities and challenges for geometric
modeling systems. A general approach to geometric modeling suitable for the Cave
Automatic Virtual Environment is described. The approach is based on alpha complexes,
and some of its capabilities are demonstrated by applying it to the study of biomolecules.
acknowledgement: We thank Ernst Miicke and Michael Facello for their work on the Alpha
shape library, and Nataraj Akkiraju for his work on the surface triangulation library.
We thank NCSA for providing access to the CAVE.
article_processing_charge: No
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Ping
full_name: Fu, Ping
last_name: Fu
- first_name: Jiang
full_name: Quian, Jiang
last_name: Quian
citation:
ama: 'Edelsbrunner H, Fu P, Quian J. Geometric modeling in CAVE. In: Proceedings
of the ACM Symposium on Virtual Reality Software and Technology. ACM; 1996:35-41
and-193-194. doi:10.1145/3304181.3304190'
apa: 'Edelsbrunner, H., Fu, P., & Quian, J. (1996). Geometric modeling in CAVE.
In Proceedings of the ACM Symposium on Virtual Reality Software and Technology
(pp. 35-41 and-193–194). Hong Kong: ACM. https://doi.org/10.1145/3304181.3304190'
chicago: Edelsbrunner, Herbert, Ping Fu, and Jiang Quian. “Geometric Modeling in
CAVE.” In Proceedings of the ACM Symposium on Virtual Reality Software and
Technology, 35-41 and-193–94. ACM, 1996. https://doi.org/10.1145/3304181.3304190.
ieee: H. Edelsbrunner, P. Fu, and J. Quian, “Geometric modeling in CAVE,” in Proceedings
of the ACM Symposium on Virtual Reality Software and Technology, Hong Kong,
1996, pp. 35-41 and-193–194.
ista: 'Edelsbrunner H, Fu P, Quian J. 1996. Geometric modeling in CAVE. Proceedings
of the ACM Symposium on Virtual Reality Software and Technology. VRST: Symposium
on Virtual Reality Software and Technology, 35-41 and-193–194.'
mla: Edelsbrunner, Herbert, et al. “Geometric Modeling in CAVE.” Proceedings
of the ACM Symposium on Virtual Reality Software and Technology, ACM, 1996,
pp. 35-41 and-193–94, doi:10.1145/3304181.3304190.
short: H. Edelsbrunner, P. Fu, J. Quian, in:, Proceedings of the ACM Symposium on
Virtual Reality Software and Technology, ACM, 1996, pp. 35-41 and-193–194.
conference:
end_date: 1996-07-04
location: Hong Kong
name: 'VRST: Symposium on Virtual Reality Software and Technology'
start_date: 1996-07-01
date_created: 2018-12-11T12:03:56Z
date_published: 1996-07-01T00:00:00Z
date_updated: 2022-08-10T13:42:02Z
day: '01'
doi: 10.1145/3304181.3304190
extern: '1'
language:
- iso: eng
month: '07'
oa_version: None
page: 35-41 and - 193-194
publication: Proceedings of the ACM Symposium on Virtual Reality Software and Technology
publication_identifier:
isbn:
- '9780897918251'
publication_status: published
publisher: ACM
publist_id: '2832'
quality_controlled: '1'
status: public
title: Geometric modeling in CAVE
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '1996'
...
---
_id: '3635'
abstract:
- lang: eng
text: Experiments on Drosophila suggest that genetic recombination may result in
lowered fitness of progeny (a 'recombination load'). This has been interpreted
as evidence either for a direct effect of recombination on fitness, or for the
maintenance of linkage disequilibria by epistatic selection. Here we show that
such a recombination load is to be expected even if selection favours increased
genetic recombination. This is because of the fact that, although a modifier may
suffer an immediate loss of fitness if it increases recombination, it eventually
becomes associated with a higher additive genetic variance in fitness, which allows
a faster response to direction selection. This argument applies to mutation-selection
balance with synergistic epistasis, directional selection on quantitative traits,
and ectopic exchange among transposable elements. Further experiments are needed
to determine whether the selection against recombination due to the immediate
load is outweighed by the increased additive variance in fitness produced by recombination.
article_processing_charge: No
article_type: original
author:
- first_name: Brian
full_name: Charlesworth, Brian
last_name: Charlesworth
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Charlesworth B, Barton NH. Recombination load associated with selection for
increased recombination. Genetical Research. 1996;67(1):27-41. doi:10.1017/S0016672300033450
apa: Charlesworth, B., & Barton, N. H. (1996). Recombination load associated
with selection for increased recombination. Genetical Research. Cambridge
University Press. https://doi.org/10.1017/S0016672300033450
chicago: Charlesworth, Brian, and Nicholas H Barton. “Recombination Load Associated
with Selection for Increased Recombination.” Genetical Research. Cambridge
University Press, 1996. https://doi.org/10.1017/S0016672300033450.
ieee: B. Charlesworth and N. H. Barton, “Recombination load associated with selection
for increased recombination,” Genetical Research, vol. 67, no. 1. Cambridge
University Press, pp. 27–41, 1996.
ista: Charlesworth B, Barton NH. 1996. Recombination load associated with selection
for increased recombination. Genetical Research. 67(1), 27–41.
mla: Charlesworth, Brian, and Nicholas H. Barton. “Recombination Load Associated
with Selection for Increased Recombination.” Genetical Research, vol. 67,
no. 1, Cambridge University Press, 1996, pp. 27–41, doi:10.1017/S0016672300033450.
short: B. Charlesworth, N.H. Barton, Genetical Research 67 (1996) 27–41.
date_created: 2018-12-11T12:04:21Z
date_published: 1996-02-01T00:00:00Z
date_updated: 2022-08-10T12:38:51Z
day: '01'
doi: 10.1017/S0016672300033450
extern: '1'
external_id:
pmid:
- '8919888 '
intvolume: ' 67'
issue: '1'
language:
- iso: eng
month: '02'
oa_version: None
page: 27 - 41
pmid: 1
publication: Genetical Research
publication_identifier:
issn:
- 0016-6723
publication_status: published
publisher: Cambridge University Press
publist_id: '2748'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Recombination load associated with selection for increased recombination
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 67
year: '1996'
...
---
_id: '3634'
abstract:
- lang: eng
text: The evolutionary processes responsible for adaptation and speciation on islands
differ in several ways from those on the mainland. Most attention has been given
to the random genetic drift that arises when a population is founded from just
a few colonizing genomes. Theoretical obstacles to 'founder effect speciation'
are discussed, together with recent proposals for avoiding them. It is argued
that although certain kinds of epistasis can facilitate the evolution of strong
reproductive isolation, this favours divergence by selection as much as by random
drift.
article_processing_charge: No
article_type: original
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: James
full_name: Mallet, James
last_name: Mallet
citation:
ama: Barton NH, Mallet J. Natural selection and random genetic drift as causes of
evolution on islands. Philosophical Transactions of the Royal Society of London
Series B, Biological Sciences. 1996;351(1341):785-795. doi:10.1098/rstb.1996.0073
apa: Barton, N. H., & Mallet, J. (1996). Natural selection and random genetic
drift as causes of evolution on islands. Philosophical Transactions of the
Royal Society of London. Series B, Biological Sciences. Royal Society of London.
https://doi.org/10.1098/rstb.1996.0073
chicago: Barton, Nicholas H, and James Mallet. “Natural Selection and Random Genetic
Drift as Causes of Evolution on Islands.” Philosophical Transactions of the
Royal Society of London. Series B, Biological Sciences. Royal Society of London,
1996. https://doi.org/10.1098/rstb.1996.0073.
ieee: N. H. Barton and J. Mallet, “Natural selection and random genetic drift as
causes of evolution on islands,” Philosophical Transactions of the Royal Society
of London. Series B, Biological Sciences, vol. 351, no. 1341. Royal Society
of London, pp. 785–795, 1996.
ista: Barton NH, Mallet J. 1996. Natural selection and random genetic drift as causes
of evolution on islands. Philosophical Transactions of the Royal Society of London.
Series B, Biological Sciences. 351(1341), 785–795.
mla: Barton, Nicholas H., and James Mallet. “Natural Selection and Random Genetic
Drift as Causes of Evolution on Islands.” Philosophical Transactions of the
Royal Society of London. Series B, Biological Sciences, vol. 351, no. 1341,
Royal Society of London, 1996, pp. 785–95, doi:10.1098/rstb.1996.0073.
short: N.H. Barton, J. Mallet, Philosophical Transactions of the Royal Society of
London. Series B, Biological Sciences 351 (1996) 785–795.
date_created: 2018-12-11T12:04:21Z
date_published: 1996-06-29T00:00:00Z
date_updated: 2022-08-10T12:57:10Z
day: '29'
doi: 10.1098/rstb.1996.0073
extern: '1'
external_id:
pmid:
- '8693020'
intvolume: ' 351'
issue: '1341'
language:
- iso: eng
month: '06'
oa_version: None
page: 785 - 795
pmid: 1
publication: Philosophical Transactions of the Royal Society of London. Series B,
Biological Sciences
publication_identifier:
issn:
- 0962-8436
publication_status: published
publisher: Royal Society of London
publist_id: '2749'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Natural selection and random genetic drift as causes of evolution on islands
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 351
year: '1996'
...
---
_id: '4024'
abstract:
- lang: eng
text: We have developed general modeling software for a Cave Automatic Virtual Environment
(CAVE); one of its applications is modeling 3D protein structures, generating
both outside-in and inside-out views of geometric models. An advantage of the
CAVE over other virtual environments is that multiple viewers can observe the
same scene at the same time and place. Our software is scalable-from high-end
virtual environments such as the CAVE, to mid-range immersive desktop systems,
down to low-end graphics workstations. In the current configuration, a parallel
Silicon Graphics Power Challenge supercomputer architecture performs the computationally
intensive construction of surface patches remotely, and sends the results through
the I-WAY (Information Wide Area Year) using VBNS (Very-high-Bandwidth Network
Systems) to the graphics machines that drive the CAVE and our graphics visualization
software, Valvis (Virtual ALpha shapes VISualizer).
article_processing_charge: No
article_type: original
author:
- first_name: Nataraj
full_name: Akkiraju, Nataraj
last_name: Akkiraju
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Ping
full_name: Fu, Ping
last_name: Fu
- first_name: Jiang
full_name: Qian, Jiang
last_name: Qian
citation:
ama: Akkiraju N, Edelsbrunner H, Fu P, Qian J. Viewing geometric protein structures
from inside a CAVE. IEEE Computer Graphics and Applications. 1996;16(4):58-61.
doi:10.1109/38.511855
apa: Akkiraju, N., Edelsbrunner, H., Fu, P., & Qian, J. (1996). Viewing geometric
protein structures from inside a CAVE. IEEE Computer Graphics and Applications.
IEEE. https://doi.org/10.1109/38.511855
chicago: Akkiraju, Nataraj, Herbert Edelsbrunner, Ping Fu, and Jiang Qian. “Viewing
Geometric Protein Structures from inside a CAVE.” IEEE Computer Graphics and
Applications. IEEE, 1996. https://doi.org/10.1109/38.511855.
ieee: N. Akkiraju, H. Edelsbrunner, P. Fu, and J. Qian, “Viewing geometric protein
structures from inside a CAVE,” IEEE Computer Graphics and Applications,
vol. 16, no. 4. IEEE, pp. 58–61, 1996.
ista: Akkiraju N, Edelsbrunner H, Fu P, Qian J. 1996. Viewing geometric protein
structures from inside a CAVE. IEEE Computer Graphics and Applications. 16(4),
58–61.
mla: Akkiraju, Nataraj, et al. “Viewing Geometric Protein Structures from inside
a CAVE.” IEEE Computer Graphics and Applications, vol. 16, no. 4, IEEE,
1996, pp. 58–61, doi:10.1109/38.511855.
short: N. Akkiraju, H. Edelsbrunner, P. Fu, J. Qian, IEEE Computer Graphics and
Applications 16 (1996) 58–61.
date_created: 2018-12-11T12:06:30Z
date_published: 1996-07-01T00:00:00Z
date_updated: 2022-08-09T13:32:21Z
day: '01'
doi: 10.1109/38.511855
extern: '1'
intvolume: ' 16'
issue: '4'
language:
- iso: eng
month: '07'
oa_version: None
page: 58 - 61
publication: IEEE Computer Graphics and Applications
publication_identifier:
issn:
- 0018-9162
publication_status: published
publisher: IEEE
publist_id: '2101'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Viewing geometric protein structures from inside a CAVE
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 16
year: '1996'
...
---
_id: '4025'
abstract:
- lang: eng
text: Questions of chemical reactivity can often be cast as questions of molecular
geometry. Common geometric models for proteins and other molecules are the space-filling
diagram, the solvent accessible surface and the molecular surface. In this paper
we present a new approach to triangulating the surface of a molecule under the
three models, which is fast, robust, and results in topologically correct triangulations.
Our computations are based on a simplicial complex dual to the molecule models.
All proposed algorithms are parallelizable.
acknowledgement: 'The research of both authors is partially supported by the Office
of Naval Research. Herbert Edelsbrunner is also supported through the Alan T. Waterman
award, grant CCR-9118874. '
article_processing_charge: No
article_type: original
author:
- first_name: Nataraj
full_name: Akkiraju, Nataraj
last_name: Akkiraju
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
citation:
ama: Akkiraju N, Edelsbrunner H. Triangulating the surface of a molecule. Discrete
Applied Mathematics. 1996;71(1-3):5-22. doi:10.1016/S0166-218X(96)00054-6
apa: Akkiraju, N., & Edelsbrunner, H. (1996). Triangulating the surface of a
molecule. Discrete Applied Mathematics. Elsevier. https://doi.org/10.1016/S0166-218X(96)00054-6
chicago: Akkiraju, Nataraj, and Herbert Edelsbrunner. “Triangulating the Surface
of a Molecule.” Discrete Applied Mathematics. Elsevier, 1996. https://doi.org/10.1016/S0166-218X(96)00054-6.
ieee: N. Akkiraju and H. Edelsbrunner, “Triangulating the surface of a molecule,”
Discrete Applied Mathematics, vol. 71, no. 1–3. Elsevier, pp. 5–22, 1996.
ista: Akkiraju N, Edelsbrunner H. 1996. Triangulating the surface of a molecule.
Discrete Applied Mathematics. 71(1–3), 5–22.
mla: Akkiraju, Nataraj, and Herbert Edelsbrunner. “Triangulating the Surface of
a Molecule.” Discrete Applied Mathematics, vol. 71, no. 1–3, Elsevier,
1996, pp. 5–22, doi:10.1016/S0166-218X(96)00054-6.
short: N. Akkiraju, H. Edelsbrunner, Discrete Applied Mathematics 71 (1996) 5–22.
date_created: 2018-12-11T12:06:30Z
date_published: 1996-12-05T00:00:00Z
date_updated: 2022-08-09T14:06:12Z
day: '05'
doi: 10.1016/S0166-218X(96)00054-6
extern: '1'
intvolume: ' 71'
issue: 1-3
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/S0166218X96000546?via%3Dihub
month: '12'
oa: 1
oa_version: Published Version
page: 5 - 22
publication: Discrete Applied Mathematics
publication_identifier:
issn:
- 0166-218X
publication_status: published
publisher: Elsevier
publist_id: '2102'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Triangulating the surface of a molecule
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 71
year: '1996'
...
---
_id: '4151'
abstract:
- lang: eng
text: 'Jaws and branchial arches together are a basic, segmented feature of the
vertebrate head, Seven arches develop in the zebrafish embryo (Danio rerio), derived
largely from neural crest cells that form the cartilaginous skeleton, In this
and the following paper we describe the phenotypes of 109 arch mutants, focusing
here on three classes that affect the posterior pharyngeal arches, including the
hyoid and five gill-bearing arches, In lockjaw, the hyoid arch is strongly reduced
and subsets of branchial arches do not develop, Mutants of a large second class,
designated the flathead group, lack several adjacent branchial arches and their
associated cartilages. Five alleles at the flathead locus all lead to larvae that
lack arches 4-6, Among 34 other flathead group members complementation tests are
incomplete, but at least six unique phenotypes can be distinguished, These all
delete continuous stretches of adjacent branchial arches and unpaired cartilages
in the ventral midline, Many show cell death in the midbrain, from which some
neural crest precursors of the arches originate, lockjaw and a few mutants in
the flathead group, including pistachio, affect both jaw cartilage and pigmentation,
reflecting essential functions of these genes in at least two neural crest lineages,
Mutants of a third class, including boxer, dackel and pincher, affect pectoral
fins and axonal trajectories in the brain, as well as the arches. Their skeletal
phenotypes suggest that they disrupt cartilage morphogenesis in all arches, Our
results suggest that there are sets of genes that: (1) specify neural crest cells
in groups of adjacent head segments, and (2) function in common genetic pathways
in a variety of tissues including the brain, pectoral fins and pigment cells as
well as pharyngeal arches.'
acknowledgement: We thank Drs Charles Kimmel, Philip Ingham, Paula Mabee and members
of the Ingham lab for critical comments on the manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Thomas
full_name: Schilling, Thomas
last_name: Schilling
- first_name: Tatjana
full_name: Piotrowski, Tatjana
last_name: Piotrowski
- first_name: Heiner
full_name: Grandel, Heiner
last_name: Grandel
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Dirk
full_name: Beuchle, Dirk
last_name: Beuchle
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Rachel
full_name: Warga, Rachel
last_name: Warga
- first_name: Torsten
full_name: Trowe, Torsten
last_name: Trowe
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: 'Schilling T, Piotrowski T, Grandel H, et al. Jaw and branchial arch mutants
in zebrafish I: Branchial arches. Development. 1996;123(1):329-344. doi:10.1242/dev.123.1.329'
apa: 'Schilling, T., Piotrowski, T., Grandel, H., Brand, M., Heisenberg, C.-P. J.,
Jiang, Y., … Nüsslein Volhard, C. (1996). Jaw and branchial arch mutants in zebrafish
I: Branchial arches. Development. Company of Biologists. https://doi.org/10.1242/dev.123.1.329'
chicago: 'Schilling, Thomas, Tatjana Piotrowski, Heiner Grandel, Michael Brand,
Carl-Philipp J Heisenberg, Yunjin Jiang, Dirk Beuchle, et al. “Jaw and Branchial
Arch Mutants in Zebrafish I: Branchial Arches.” Development. Company of
Biologists, 1996. https://doi.org/10.1242/dev.123.1.329.'
ieee: 'T. Schilling et al., “Jaw and branchial arch mutants in zebrafish
I: Branchial arches,” Development, vol. 123, no. 1. Company of Biologists,
pp. 329–344, 1996.'
ista: 'Schilling T, Piotrowski T, Grandel H, Brand M, Heisenberg C-PJ, Jiang Y,
Beuchle D, Hammerschmidt M, Kane D, Mullins M, Van Eeden F, Kelsh R, Furutani
Seiki M, Granato M, Haffter P, Odenthal J, Warga R, Trowe T, Nüsslein Volhard
C. 1996. Jaw and branchial arch mutants in zebrafish I: Branchial arches. Development.
123(1), 329–344.'
mla: 'Schilling, Thomas, et al. “Jaw and Branchial Arch Mutants in Zebrafish I:
Branchial Arches.” Development, vol. 123, no. 1, Company of Biologists,
1996, pp. 329–44, doi:10.1242/dev.123.1.329.'
short: T. Schilling, T. Piotrowski, H. Grandel, M. Brand, C.-P.J. Heisenberg, Y.
Jiang, D. Beuchle, M. Hammerschmidt, D. Kane, M. Mullins, F. Van Eeden, R. Kelsh,
M. Furutani Seiki, M. Granato, P. Haffter, J. Odenthal, R. Warga, T. Trowe, C.
Nüsslein Volhard, Development 123 (1996) 329–344.
date_created: 2018-12-11T12:07:15Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-08T08:41:00Z
day: '01'
doi: 10.1242/dev.123.1.329
extern: '1'
external_id:
pmid:
- '9007253'
intvolume: ' 123'
issue: '1'
language:
- iso: eng
month: '12'
oa_version: None
page: 329 - 344
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1968'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Jaw and branchial arch mutants in zebrafish I: Branchial arches'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4166'
abstract:
- lang: eng
text: In a large scale screen for mutants with defects in the embryonic development
of the zebrafish we identified mutations in four genes, floating head (flh), memo
(mom), no tail (ntl), and dec, that are required for early notochord formation.
Mutations in flh and ntl have been described previously, while mom and doe are
newly identified genes. Mutant mom embryos lack a notochord in the trunk, and
trunk somites from the right and left side of the embryo fuse underneath the neural
tube. In this respect morn appears similar to flh. In contrast, notochord precursor
cells are present in both ntl and doc embryos. In order to gain a greater understanding
of the phenotypes, we have analysed the expression of several axial mesoderm markers
in mutant embryos of all four genes. In flh and mom, Ntl expression is normal
in the germ ring and tailbud, while the expression of Nd and other notochord markers
in the axial mesodermal region is disrupted. Nd expression is normal in doc embryos
until early semitic stages, when there is a reduction in expression which is first
seen in anterior regions of the embryo. This suggests a function for doc in the
maintenance of ntl expression. Other notochord markers such as twist, sonic hedgehog
and axial are not expressed in the axial mesoderm of ntl embryos, their expression
parallels the expression of ntl in the axial mesoderm of mutant doc,flh and mom
embryos, indicating that ntl is required for the expression of these markers.
The role of doc in the expression of the notochord markers appears indirect via
ntl. Floor plate formation is disrupted in most regions in flh and mom mutant
embryos but is present in mutant ntl and doc embryos. In mutant embryos with strong
ntl alleles the band of cells expressing floor plate markers is broadened. A similar
broadening is also observed in the axial mesoderm underlying the floor plate of
ntl embryos, suggesting a direct involvement of the notochord precursor cells
in floor plate induction. Mutations in al of these four genes result in embryos
lacking a horizontal myoseptum and muscle pioneer cells, both of which are thought
to be induced by the notochord. These somite defects can be traced back to an
impairment of the specification of the adaxial cells during early stages of development.
Transplantation of wild-type cells into mutant doc embryos reveals that wild-type
notochord cells are sufficient to induce horizontal myoseptum formation in the
flanking mutant tissue. Thus dec, like flh and ntl, acts cell autonomously in
the notochord. In addition to the four mutants with defects in early notochord
formation, we have isolated 84 mutants, defining at least 15 genes, with defects
in later stages of notochord development. These are listed in an appendix to this
study.
acknowledgement: We thank Bob Riggleman for providing the twist probe prior to publication,
William Talbot, Anne Melby, Marnie Halpern and Chuck Kimmel for communicating results
prior to publication, Bill Trevarrow for the flhn1 allele, Stefan Schulte-Merker
for providing the ntl antibody, and N. H. Patel for providing the Eng antibody (4D9).
We thank Klaus Trummler, Frank Uhlmann and Mathias Metz for assistance in the analysis
of the ntl alleles, Silke Rudolph for technical assistance, Heike Schauerte for
helping with the in situ hybridization, and Joel Wilson and Cornelia Fricke for
their help with the fish work, and finally Tanya Whitfield, Francisco Pelegri, Darren
Gilmour and Stefan Schulte-Merker for discussion and help with the manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Elisabeth
full_name: Vogelsang, Elisabeth
last_name: Vogelsang
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Rachel
full_name: Warga, Rachel
last_name: Warga
- first_name: Miguel
full_name: Allende, Miguel
last_name: Allende
- first_name: Eric
full_name: Weinberg, Eric
last_name: Weinberg
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Odenthal J, Haffter P, Vogelsang E, et al. Mutations affecting the formation
of the notochord in the zebrafish, Danio rerio. Development. 1996;123(1):103-115.
doi:10.1242/dev.123.1.103
apa: Odenthal, J., Haffter, P., Vogelsang, E., Brand, M., Van Eeden, F., Furutani
Seiki, M., … Nüsslein Volhard, C. (1996). Mutations affecting the formation of
the notochord in the zebrafish, Danio rerio. Development. Company of Biologists.
https://doi.org/10.1242/dev.123.1.103
chicago: Odenthal, Jörg, Pascal Haffter, Elisabeth Vogelsang, Michael Brand, Fredericus
Van Eeden, Makoto Furutani Seiki, Michael Granato, et al. “Mutations Affecting
the Formation of the Notochord in the Zebrafish, Danio Rerio.” Development.
Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.103.
ieee: J. Odenthal et al., “Mutations affecting the formation of the notochord
in the zebrafish, Danio rerio,” Development, vol. 123, no. 1. Company of
Biologists, pp. 103–115, 1996.
ista: Odenthal J, Haffter P, Vogelsang E, Brand M, Van Eeden F, Furutani Seiki M,
Granato M, Hammerschmidt M, Heisenberg C-PJ, Jiang Y, Kane D, Kelsh R, Mullins
M, Warga R, Allende M, Weinberg E, Nüsslein Volhard C. 1996. Mutations affecting
the formation of the notochord in the zebrafish, Danio rerio. Development. 123(1),
103–115.
mla: Odenthal, Jörg, et al. “Mutations Affecting the Formation of the Notochord
in the Zebrafish, Danio Rerio.” Development, vol. 123, no. 1, Company of
Biologists, 1996, pp. 103–15, doi:10.1242/dev.123.1.103.
short: J. Odenthal, P. Haffter, E. Vogelsang, M. Brand, F. Van Eeden, M. Furutani
Seiki, M. Granato, M. Hammerschmidt, C.-P.J. Heisenberg, Y. Jiang, D. Kane, R.
Kelsh, M. Mullins, R. Warga, M. Allende, E. Weinberg, C. Nüsslein Volhard, Development
123 (1996) 103–115.
date_created: 2018-12-11T12:07:21Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-08T08:06:12Z
day: '01'
doi: 10.1242/dev.123.1.103
extern: '1'
external_id:
pmid:
- '9007233'
intvolume: ' 123'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://journals.biologists.com/dev/article/123/1/103/39325/Mutations-affecting-the-formation-of-the-notochord
month: '12'
oa: 1
oa_version: Published Version
page: 103 - 115
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1954'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mutations affecting the formation of the notochord in the zebrafish, Danio
rerio
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4170'
abstract:
- lang: eng
text: We identified 6 genes that are essential for specifying ventral regions of
the early zebrafish embryo, Mutations in these genes cause an expansion of structures
normally derived from dorsal-lateral regions of the blastula at the expense of
ventrally derived structures, A series of phenotypes of varied strengths is observed
with different alleles of these mutants, The weakest phenotype is a reduction
in the ventral tail fin, observed as a dominant phenotype of swirl, piggytail,
and somitabun and a recessive phenotype of min fin, lost-a-fin and some piggytail
alleles, With increasing phenotypic strength, the blood and pronephric anlagen
are also reduced or absent, while the paraxial mesoderm and anterior neuroectoderm
is progressively expanded, In the strong phenotypes, displayed by homozygous embryos
of snailhouse, swirl and somitabun, the somites circle around the embryo and the
midbrain region is expanded laterally, Several mutations in this group of genes
are semidominant as well as recessive indicating a strong dosage sensitivity of
the processes involved, Mutations in the piggytail gene display an unusual dominance
that depends on both a maternal and zygotic heterozygous genotype, while somitabun
is a fully penetrant dominant maternal-effect mutation, The similar and overlapping
phenotypes of mutants of the 6 genes identified suggest that they function in
a common pathway, which begins in oogenesis, but also depends on factors provided
after the onset of zygotic transcription, presumably during blastula stages, This
pathway provides ventral positional information, counteracting the dorsalizing
instructions of the organizer, which is localized in the dorsal shield.
acknowledgement: 'We would like to thank: Eric Weinberg, and David Ransom and Leonard
Zon for providing the myoD and gata1 cDNA clone, respectively, prior to publication;
David Ransom for pointing out the histological blood staining method; J. S. Joly
for the eve1 cDNA clone; Mary Ellen Lane, Siegfried Roth, Stefan Schulte-Merker,
Herbert Steinbeiser for helpful comments on the manuscript; and very special thanks
to Karin Finger-Miller for technical support, as well as to Hans-Martin Maischein,
Amanda Wilson, Jörg Zeller, and Cosima Fabian. This work was supported by an NIH
postdoctoral fellowship to M. C. M.'
article_processing_charge: No
article_type: original
author:
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: 'Mullins M, Hammerschmidt M, Kane D, et al. Genes establishing dorsoventral
pattern formation in the zebrafish embryo: The ventral specifying genes. Development.
1996;123(1):81-93. doi:10.1242/dev.123.1.81'
apa: 'Mullins, M., Hammerschmidt, M., Kane, D., Odenthal, J., Brand, M., Van Eeden,
F., … Nüsslein Volhard, C. (1996). Genes establishing dorsoventral pattern formation
in the zebrafish embryo: The ventral specifying genes. Development. Company
of Biologists. https://doi.org/10.1242/dev.123.1.81'
chicago: 'Mullins, Mary, Matthias Hammerschmidt, Donald Kane, Jörg Odenthal, Michael
Brand, Fredericus Van Eeden, Makoto Furutani Seiki, et al. “Genes Establishing
Dorsoventral Pattern Formation in the Zebrafish Embryo: The Ventral Specifying
Genes.” Development. Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.81.'
ieee: 'M. Mullins et al., “Genes establishing dorsoventral pattern formation
in the zebrafish embryo: The ventral specifying genes,” Development, vol.
123, no. 1. Company of Biologists, pp. 81–93, 1996.'
ista: 'Mullins M, Hammerschmidt M, Kane D, Odenthal J, Brand M, Van Eeden F, Furutani
Seiki M, Granato M, Haffter P, Heisenberg C-PJ, Jiang Y, Kelsh R, Nüsslein Volhard
C. 1996. Genes establishing dorsoventral pattern formation in the zebrafish embryo:
The ventral specifying genes. Development. 123(1), 81–93.'
mla: 'Mullins, Mary, et al. “Genes Establishing Dorsoventral Pattern Formation in
the Zebrafish Embryo: The Ventral Specifying Genes.” Development, vol.
123, no. 1, Company of Biologists, 1996, pp. 81–93, doi:10.1242/dev.123.1.81.'
short: M. Mullins, M. Hammerschmidt, D. Kane, J. Odenthal, M. Brand, F. Van Eeden,
M. Furutani Seiki, M. Granato, P. Haffter, C.-P.J. Heisenberg, Y. Jiang, R. Kelsh,
C. Nüsslein Volhard, Development 123 (1996) 81–93.
date_created: 2018-12-11T12:07:22Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-05T12:01:06Z
day: '01'
doi: 10.1242/dev.123.1.81
extern: '1'
external_id:
pmid:
- '9007231'
intvolume: ' 123'
issue: '1'
language:
- iso: eng
month: '12'
oa_version: None
page: 81 - 93
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1951'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Genes establishing dorsoventral pattern formation in the zebrafish embryo:
The ventral specifying genes'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4164'
abstract:
- lang: eng
text: In a large-scale screen for mutants with defects in embryonic development
we identified 17 genes (65 mutants) specifically required for the development
of xanthophores, We provide evidence that these genes are required for three different
aspects of xanthophore development, (1) Pigment cell formation and migration (pfeffer
and salt); (2) pigment synthesis (edison, yobo, yocca and brie) and (3) pigment
translocation (esrom, tilsit and tofu). The number of xanthophore cells that appear
in the body is reduced in embryos with mutations in the two genes, salt and pfeffer.
In heterozygous and homozygous salt and pfeffer adults, the melanophore stripes
are interrupted, indicating that xanthophore cells have an important function
in adult melanophore pattern formation, Most other genes affect only larval pigmentation,
In embryos mutant for edison, yobo, yocca and brie, differences in pteridine synthesis
can be observed under UV light and by thin-layer chromatography. Homozygous mutant
females of yobo show a recessive maternal effect, Embryonic development is slowed
down and embryos display head and tail truncations, Xanthophores in larvae mutant
in the three genes esrom, tilsit and tofu appear less spread out, In addition,
these mutants display a defect in retinotectal axon pathfinding, These mutations
may affect xanthophore pigment distribution within the cells or xanthophore cell
shape, Mutations in seven genes affecting xanthophore pigmentation remain unclassified.
acknowledgement: We thank Silke Rudolph for technical assistance, Joel Wilson and
Cornelia Fricke for their help in the fish work and the thin layer chromatography,
and Darren Gilmour for help with the manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Karin
full_name: Rossnagel, Karin
last_name: Rossnagel
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Elisabeth
full_name: Vogelsang, Elisabeth
last_name: Vogelsang
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Odenthal J, Rossnagel K, Haffter P, et al. Mutations affecting xanthophore
pigmentation in the zebrafish, Danio rerio. Development. 1996;123(1):391-398.
doi:10.1242/dev.123.1.391
apa: Odenthal, J., Rossnagel, K., Haffter, P., Kelsh, R., Vogelsang, E., Brand,
M., … Nüsslein Volhard, C. (1996). Mutations affecting xanthophore pigmentation
in the zebrafish, Danio rerio. Development. Company of Biologists. https://doi.org/10.1242/dev.123.1.391
chicago: Odenthal, Jörg, Karin Rossnagel, Pascal Haffter, Robert Kelsh, Elisabeth
Vogelsang, Michael Brand, Fredericus Van Eeden, et al. “Mutations Affecting Xanthophore
Pigmentation in the Zebrafish, Danio Rerio.” Development. Company of Biologists,
1996. https://doi.org/10.1242/dev.123.1.391.
ieee: J. Odenthal et al., “Mutations affecting xanthophore pigmentation in
the zebrafish, Danio rerio,” Development, vol. 123, no. 1. Company of Biologists,
pp. 391–398, 1996.
ista: Odenthal J, Rossnagel K, Haffter P, Kelsh R, Vogelsang E, Brand M, Van Eeden
F, Furutani Seiki M, Granato M, Hammerschmidt M, Heisenberg C-PJ, Jiang Y, Kane
D, Mullins M, Nüsslein Volhard C. 1996. Mutations affecting xanthophore pigmentation
in the zebrafish, Danio rerio. Development. 123(1), 391–398.
mla: Odenthal, Jörg, et al. “Mutations Affecting Xanthophore Pigmentation in the
Zebrafish, Danio Rerio.” Development, vol. 123, no. 1, Company of Biologists,
1996, pp. 391–98, doi:10.1242/dev.123.1.391.
short: J. Odenthal, K. Rossnagel, P. Haffter, R. Kelsh, E. Vogelsang, M. Brand,
F. Van Eeden, M. Furutani Seiki, M. Granato, M. Hammerschmidt, C.-P.J. Heisenberg,
Y. Jiang, D. Kane, M. Mullins, C. Nüsslein Volhard, Development 123 (1996) 391–398.
date_created: 2018-12-11T12:07:20Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-08T08:08:51Z
day: '01'
doi: 10.1242/dev.123.1.391
extern: '1'
external_id:
pmid:
- '9007257 '
intvolume: ' 123'
issue: '1'
language:
- iso: eng
month: '12'
oa_version: None
page: 391 - 398
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1955'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mutations affecting xanthophore pigmentation in the zebrafish, Danio rerio
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4212'
abstract:
- lang: eng
text: In a large-scale screen, we isolated mutants displaying a specific visible
phenotype in embryos or early larvae of the zebrafish, Danio rerio. Males were
mutagenized with ethylnitrosourea (ENU) and F-2 families of single pair matings
between sibling F-l fish, heterozygous for a mutagenized genome, were raised.
Egg lays were obtained from several crosses between F-2 siblings, resulting in
scoring of 3857 mutagenized genomes. F-3 progeny were scored at the second, third
and sixth day of development, using a stereomicroscope. In a subsequent screen,
fixed embryos were analyzed for correct retinotectal projection. A total of 4264
mutants were identified. Two thirds of the mutants displaying rather general abnormalities
were eventually discarded. We kept and characterized 1163 mutants. In complementation
crosses performed between mutants with similar phenotypes, 894 mutants have been
assigned to 372 genes. The average allele frequency is 2.4. We identified genes
involved in early development, notochord, brain, spinal cord, somites, muscles,
heart, circulation, blood, skin, fin, eye, otic vesicle, jaw and branchial arches,
pigment pattern, pigment formation, gut, liver, motility and touch response. Our
collection contains alleles of almost all previously described zebrafish mutants.
From the allele frequencies and other considerations we estimate that the 372
genes defined by the mutants probably represent more than half of all genes that
could have been discovered using the criteria of our screen. Here we give an overview
of the spectrum of mutant phenotypes obtained, and discuss the limits and the
potentials of a genetic saturation screen in the zebrafish.
acknowledgement: "This work was a collaborative effort in which a large number of
people participated during all or part of the three years of raising the families,
screening and evaluation of the mutants. We thank Rachel Warga, Tatjana Piotrowski,
Francisco Pelegri, Karin Rossnagel and Hans-Martin Maischein for collaboration at
the beginning and the end of the screening and evaluation periods respectively;
Hans-Georg Frohnhöfer for fish health care and for establishing the Tübingen zebrafish
stockcenter; and Wolfgang Driever, Marc Fishman and collaborators, for sharing unpublished
results. We enjoyed the visits of Alison Brownlie, Jau-Nian Chen, Nancy Hopkins,
Corinne Houart, Shuo Lin, David Ransom, Thomas Schilling, Tanya Whitfield and Catherine
Willet, who participated in the analysis of individual mutant classes. We also want
to thank many undergraduate students from the Tübingen University for conscientious
and efficient help in the maintenance and identification of fish, and Torsten Trowe,
Rolf Karlstrom, Barbara Grunwald and Friedrich Bonhoeffer for pleasant and interesting
conversations and collaborations. We thank the staff of our workshop for patience,
\r\n Inventiveness and a very large number of fish containers. We thank Herwig Baier,
Robert Geisler, Darren Gilmour,\r\nNancy Hopkins, Suresh Jesuthasan, Gerd Jürgens,
Francisco Pelegri, Siegfried Roth, Stefan Schulte-Merker, Ralf Sommer, Daniel St
Johnston and Tanya Whitfield, for many helpful suggestions on the manuscript; Robert
Geisler for invaluable help with computers, cameras and colour printers, and the
Tübingen fly group for interest, endless patience and support."
article_processing_charge: No
article_type: original
author:
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Elisabeth
full_name: Vogelsang, Elisabeth
last_name: Vogelsang
- first_name: Dirk
full_name: Beuchle, Dirk
last_name: Beuchle
- first_name: Ursula
full_name: Schach, Ursula
last_name: Schach
- first_name: Cosima
full_name: Fabian, Cosima
last_name: Fabian
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Haffter P, Granato M, Brand M, et al. The identification of genes with unique
and essential functions in the development of the zebrafish, Danio rerio. Development.
1996;123(1):1-36. doi:10.1242/dev.123.1.1
apa: Haffter, P., Granato, M., Brand, M., Mullins, M., Hammerschmidt, M., Kane,
D., … Nüsslein Volhard, C. (1996). The identification of genes with unique and
essential functions in the development of the zebrafish, Danio rerio. Development.
Company of Biologists. https://doi.org/10.1242/dev.123.1.1
chicago: Haffter, Pascal, Michael Granato, Michael Brand, Mary Mullins, Matthias
Hammerschmidt, Donald Kane, Jörg Odenthal, et al. “The Identification of Genes
with Unique and Essential Functions in the Development of the Zebrafish, Danio
Rerio.” Development. Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.1 .
ieee: P. Haffter et al., “The identification of genes with unique and essential
functions in the development of the zebrafish, Danio rerio,” Development,
vol. 123, no. 1. Company of Biologists, pp. 1–36, 1996.
ista: Haffter P, Granato M, Brand M, Mullins M, Hammerschmidt M, Kane D, Odenthal
J, Van Eeden F, Jiang Y, Heisenberg C-PJ, Kelsh R, Furutani Seiki M, Vogelsang
E, Beuchle D, Schach U, Fabian C, Nüsslein Volhard C. 1996. The identification
of genes with unique and essential functions in the development of the zebrafish,
Danio rerio. Development. 123(1), 1–36.
mla: Haffter, Pascal, et al. “The Identification of Genes with Unique and Essential
Functions in the Development of the Zebrafish, Danio Rerio.” Development,
vol. 123, no. 1, Company of Biologists, 1996, pp. 1–36, doi:10.1242/dev.123.1.1 .
short: P. Haffter, M. Granato, M. Brand, M. Mullins, M. Hammerschmidt, D. Kane,
J. Odenthal, F. Van Eeden, Y. Jiang, C.-P.J. Heisenberg, R. Kelsh, M. Furutani
Seiki, E. Vogelsang, D. Beuchle, U. Schach, C. Fabian, C. Nüsslein Volhard, Development
123 (1996) 1–36.
date_created: 2018-12-11T12:07:37Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-04T14:41:37Z
day: '01'
doi: '10.1242/dev.123.1.1 '
extern: '1'
external_id:
pmid:
- '9007226 '
intvolume: ' 123'
issue: '1'
language:
- iso: eng
month: '12'
oa_version: None
page: 1 - 36
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1905'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The identification of genes with unique and essential functions in the development
of the zebrafish, Danio rerio
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4214'
abstract:
- lang: eng
text: 'Zebrafish embryos and larvae have stage-specific patterns of motility or
locomotion, Two embryonic structures accomplish this behavior: the central nervous
system (CNS) and skeletal muscles. To identify genes that are functionally involved
in mediating and controlling different patterns of embryonic and larval motility,
we included a simple touch response test in our zebrafish large-scale genetic
screen, In total we identified 166 mutants with specific defects in embryonic
motility. These mutants fall into 14 phenotypically distinct groups comprising
at least 48 genes, Here we describe the various phenotypic groups including mutants
with no or reduced motility, mechanosensory defective mutants, ''spastic'' mutants,
circling mutants and motor circuit defective mutants, In 63 mutants, defining
18 genes, striation of semitic muscles is reduced, Phenotypic analysis provides
evidence that these 18 genes have distinct and consecutive functions during semitic
muscle development. The genes sloth (slo) and frozen (fro) already act during
myoblast differentiation, while 13 genes appear to function later, in the formation
of myofibers and the organization of sarcomeres, Mutations in four other genes
result in muscle-specific degeneration, 103 mutations, defining at least 30 genes,
cause no obvious defects in muscle formation and may instead affect neuronal development.
Analysis of the behavioral defects suggests that these genes participate in the
diverse locomotion patterns observed, such as touch response, rhythmic tail movements,
equilibrium control, or that they simply confer general motility to the animal,
In some of these mutants specific defects in the developing nervous system are
detected, Mutations in two genes, nevermind (nev) and macho (mao), affect axonal
projection in the optic tectum, whereas axon formation and elongation of motorneurons
are disrupted by mutations in the diwanka (diw) and the unplugged (unp) genes.'
acknowledgement: We would like to thank C. Kimmel, J. Eisen and M. Westerfield for
providing the nic and fub mutant strains used for complementation and for the znp1
antibody. In addition we thank Tanja Whitfield and Suresh Jesuthesan for critical
reading of the manuscript. This work was supported by a DFG postdoctoral fellowship
Gr 1370/1-1 to M.G.
article_processing_charge: No
article_type: original
author:
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Ursula
full_name: Schach, Ursula
last_name: Schach
- first_name: Torsten
full_name: Trowe, Torsten
last_name: Trowe
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Granato M, Van Eeden F, Schach U, et al. Genes controlling and mediating locomotion
behavior of the zebrafish embryo and larva. Development. 1996;123:399-413.
doi:10.1242/dev.123.1.399
apa: Granato, M., Van Eeden, F., Schach, U., Trowe, T., Brand, M., Furutani Seiki,
M., … Nüsslein Volhard, C. (1996). Genes controlling and mediating locomotion
behavior of the zebrafish embryo and larva. Development. Company of Biologists.
https://doi.org/10.1242/dev.123.1.399
chicago: Granato, Michael, Fredericus Van Eeden, Ursula Schach, Torsten Trowe, Michael
Brand, Makoto Furutani Seiki, Pascal Haffter, et al. “Genes Controlling and Mediating
Locomotion Behavior of the Zebrafish Embryo and Larva.” Development. Company
of Biologists, 1996. https://doi.org/10.1242/dev.123.1.399.
ieee: M. Granato et al., “Genes controlling and mediating locomotion behavior
of the zebrafish embryo and larva,” Development, vol. 123. Company of Biologists,
pp. 399–413, 1996.
ista: Granato M, Van Eeden F, Schach U, Trowe T, Brand M, Furutani Seiki M, Haffter
P, Hammerschmidt M, Heisenberg C-PJ, Jiang Y, Kane D, Kelsh R, Mullins M, Odenthal
J, Nüsslein Volhard C. 1996. Genes controlling and mediating locomotion behavior
of the zebrafish embryo and larva. Development. 123, 399–413.
mla: Granato, Michael, et al. “Genes Controlling and Mediating Locomotion Behavior
of the Zebrafish Embryo and Larva.” Development, vol. 123, Company of Biologists,
1996, pp. 399–413, doi:10.1242/dev.123.1.399.
short: M. Granato, F. Van Eeden, U. Schach, T. Trowe, M. Brand, M. Furutani Seiki,
P. Haffter, M. Hammerschmidt, C.-P.J. Heisenberg, Y. Jiang, D. Kane, R. Kelsh,
M. Mullins, J. Odenthal, C. Nüsslein Volhard, Development 123 (1996) 399–413.
date_created: 2018-12-11T12:07:38Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-04T14:20:50Z
day: '01'
doi: 10.1242/dev.123.1.399
extern: '1'
external_id:
pmid:
- '9007258'
intvolume: ' 123'
language:
- iso: eng
month: '12'
oa_version: None
page: 399 - 413
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1904'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Genes controlling and mediating locomotion behavior of the zebrafish embryo
and larva
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4215'
abstract:
- lang: eng
text: In a screen for early developmental mutants of the zebrafish, we have identified
mutations specifically affecting the internal organs, We identified 53 mutations
affecting the cardiovascular system, Nine of them affect specific landmarks of
heart morphogenesis. Mutations in four genes cause a failure in the fusion of
the bilateral heart primordia, resulting in cardia bifida. In lonely atrium, no
heart venticle is visible and the atrium is directly fused to the outflow tract.
In the overlooped mutant, the relative position of the two heart chambers is distorted,
The heart is enormously enlarged in the santa mutant, In two mutants, scotch tape
and superglue, the cardiac jelly between the two layers of the heart is significantly
reduced, We also identified a number of mutations affecting the function of the
heart, The mutations affecting heart function can be subdivided into two groups,
one affecting heart contraction and another affecting the rhythm of the heart
beat. Among the contractility group of mutants are 5 with no heart beat at all
and 15 with a reduced heart beat of one or both chambers, 6 mutations are in the
rhythmicity group and specifically affect the beating pattern of the heart, Mutations
in two genes, bypass and kurzschluss, cause specific defects in the circulatory
system, In addition to the heart mutants, we identified 23 mutations affecting
the integrity of the liver, the intestine or the kidney, In this report, we demonstrate
that it is feasible to screen for genes specific for the patterning or function
of certain internal organs in the zebrafish, The mutations presented here could
serve as an entrypoint to the establishment of a genetic hierarchy underlying
organogenesis.
acknowledgement: We thank Chris Simpson and Colleen Boggs for excellent technical
help. We thank Mark C. Fishman for the advice and providing fish for complementation;
Bernadette Fouquet, Kerri S. Warren and Brant M. Weinstein for critically reading
the manuscript. JNC is supported in part by NIH grant RO1-HL49579 to Mark C. Fishman.
article_processing_charge: No
article_type: original
author:
- first_name: Jaunian
full_name: Chen, Jaunian
last_name: Chen
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Elisabeth
full_name: Vogelsang, Elisabeth
last_name: Vogelsang
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Chen J, Haffter P, Odenthal J, et al. Mutations affecting the cardiovascular
system and other internal organs in zebrafish. Development. 1996;123:293-302.
doi:10.1242/dev.123.1.293
apa: Chen, J., Haffter, P., Odenthal, J., Vogelsang, E., Brand, M., Van Eeden, F.,
… Nüsslein Volhard, C. (1996). Mutations affecting the cardiovascular system and
other internal organs in zebrafish. Development. Company of Biologists.
https://doi.org/10.1242/dev.123.1.293
chicago: Chen, Jaunian, Pascal Haffter, Jörg Odenthal, Elisabeth Vogelsang, Michael
Brand, Fredericus Van Eeden, Makoto Furutani Seiki, et al. “Mutations Affecting
the Cardiovascular System and Other Internal Organs in Zebrafish.” Development.
Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.293.
ieee: J. Chen et al., “Mutations affecting the cardiovascular system and
other internal organs in zebrafish,” Development, vol. 123. Company of
Biologists, pp. 293–302, 1996.
ista: Chen J, Haffter P, Odenthal J, Vogelsang E, Brand M, Van Eeden F, Furutani
Seiki M, Granato M, Hammerschmidt M, Heisenberg C-PJ, Jiang Y, Kane D, Kelsh R,
Mullins M, Nüsslein Volhard C. 1996. Mutations affecting the cardiovascular system
and other internal organs in zebrafish. Development. 123, 293–302.
mla: Chen, Jaunian, et al. “Mutations Affecting the Cardiovascular System and Other
Internal Organs in Zebrafish.” Development, vol. 123, Company of Biologists,
1996, pp. 293–302, doi:10.1242/dev.123.1.293.
short: J. Chen, P. Haffter, J. Odenthal, E. Vogelsang, M. Brand, F. Van Eeden, M.
Furutani Seiki, M. Granato, M. Hammerschmidt, C.-P.J. Heisenberg, Y. Jiang, D.
Kane, R. Kelsh, M. Mullins, C. Nüsslein Volhard, Development 123 (1996) 293–302.
date_created: 2018-12-11T12:07:38Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-04T13:11:56Z
day: '01'
doi: 10.1242/dev.123.1.293
extern: '1'
external_id:
pmid:
- '9007249'
intvolume: ' 123'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://journals.biologists.com/dev/article/123/1/293/39344/Mutations-affecting-the-cardiovascular-system-and
month: '12'
oa: 1
oa_version: Published Version
page: 293 - 302
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1902'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mutations affecting the cardiovascular system and other internal organs in
zebrafish
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4213'
abstract:
- lang: eng
text: 'Forty zebrafish mutants with localized or general neural degeneration are
described. The onset and duration of degeneration and the distribution of ectopically
dying cells are specific characteristics of each mutant, Mutants are classified
into four groups by these parameters. Class I: late focal neural degeneration
mutants, These 18 mutants have restricted cell death mainly in the tectum and
the dorsal hindbrain after 36 hours, The degeneration does not spread and disappears
at later stages of development. Class LI: early focal neural degeneration mutants.
Ten mutants in this class exhibit transient restricted degeneration affecting
mainly the diencephalon, the hindbrain and the spinal cord at 20 hours, The midbrain
is less affected. The degeneration shifts to the dorsal diencephalon and the tectum
at 36 hours. Class III: late spreading neural degeneration mutants. The 8 mutants
in this class display a degeneration that is first seen in the tectum and subsequently
spreads throughout the nervous system from 36 hours on. Class IV: early general
neural degeneration mutants, This class of four mutants already shows overall
cell degeneration in the nervous system at the 15-somite stage. Three of the class
I mutants show a change in the pattern of gene expression in the anlage of a brain
structure prior to the onset of degeneration. These results suggest that focal
cell death may be a useful clue for the detection of early patterning defects
of the vertebrate nervous system in regions devoid of visible landmarks.'
acknowledgement: We are grateful to Rachel Warga, Tatijana Piotrowski, Francisco Pelegri
and Tomas Schilling for sharing unpublished results. We thank Heinz Schwarz for
histological sections and Eric Weinberg, Monte Westerfield, Stephen Wilson and Hitoshi
Okamoto for in situprobes. We also thank Nancy Hopkins, Francisco Pelegri and Stefan
Schulte-Merker for helpful suggestions on the manuscript, and Raymond Lamos for
technical support.
article_processing_charge: No
article_type: original
author:
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Corinne
full_name: Houart, Corinne
last_name: Houart
- first_name: Dirk
full_name: Beuchle, Dirk
last_name: Beuchle
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Furutani Seiki M, Jiang Y, Brand M, et al. Neural degeneration mutants in the
zebrafish, Danio rerio. Development. 1996;123(1):229-239. doi:10.1242/dev.123.1.229
apa: Furutani Seiki, M., Jiang, Y., Brand, M., Heisenberg, C.-P. J., Houart, C.,
Beuchle, D., … Nüsslein Volhard, C. (1996). Neural degeneration mutants in the
zebrafish, Danio rerio. Development. Company of Biologists. https://doi.org/10.1242/dev.123.1.229
chicago: Furutani Seiki, Makoto, Yunjin Jiang, Michael Brand, Carl-Philipp J Heisenberg,
Corinne Houart, Dirk Beuchle, Fredericus Van Eeden, et al. “Neural Degeneration
Mutants in the Zebrafish, Danio Rerio.” Development. Company of Biologists,
1996. https://doi.org/10.1242/dev.123.1.229
.
ieee: M. Furutani Seiki et al., “Neural degeneration mutants in the zebrafish,
Danio rerio,” Development, vol. 123, no. 1. Company of Biologists, pp.
229–239, 1996.
ista: Furutani Seiki M, Jiang Y, Brand M, Heisenberg C-PJ, Houart C, Beuchle D,
Van Eeden F, Granato M, Haffter P, Hammerschmidt M, Kane D, Kelsh R, Mullins M,
Odenthal J, Nüsslein Volhard C. 1996. Neural degeneration mutants in the zebrafish,
Danio rerio. Development. 123(1), 229–239.
mla: Furutani Seiki, Makoto, et al. “Neural Degeneration Mutants in the Zebrafish,
Danio Rerio.” Development, vol. 123, no. 1, Company of Biologists, 1996,
pp. 229–39, doi:10.1242/dev.123.1.229
.
short: M. Furutani Seiki, Y. Jiang, M. Brand, C.-P.J. Heisenberg, C. Houart, D.
Beuchle, F. Van Eeden, M. Granato, P. Haffter, M. Hammerschmidt, D. Kane, R. Kelsh,
M. Mullins, J. Odenthal, C. Nüsslein Volhard, Development 123 (1996) 229–239.
date_created: 2018-12-11T12:07:37Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-04T14:02:39Z
day: '01'
doi: '10.1242/dev.123.1.229 '
extern: '1'
external_id:
pmid:
- '9007243 '
intvolume: ' 123'
issue: '1'
language:
- iso: eng
month: '12'
oa_version: None
page: 229 - 239
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1903'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Neural degeneration mutants in the zebrafish, Danio rerio
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4208'
abstract:
- lang: eng
text: 'We have identified several genes that are required for various morphogenetic
processes during gastrulation and tail formation, Two genes are required in the
anterior region of the body axis: one eyed pinhead (oep) and dir ty nose (dns).
oep mutant embryos are defective in prechordal plate formation and the specification
of anterior and ventral structures of the central nervous system, In dns mutants,
cells of the prechordal plate, such as the prospective hatching gland cells, fail
to specify. Two genes are required for convergence and extension movements. In
mutant trilobite embryos, extension movements on the dorsal side of the embryo
are affected, whereas in the formerly described spadetail mutants, for which two
new alleles have been isolated, convergent movements of ventrolateral cells to
the dorsal side are blocked. Two genes are required for the development of the
posterior end of the body axis, In pipetail mutants, the tailbud fails to move
ventrally on the yolk sac after germ ring closure, and the tip of the tail fails
to detach from the yolk tube. Mutants in kugelig (kgg) do not form the yolk tube
at the posterior side of the yolk sac.'
acknowledgement: M. H. and F. P. contributed equally to this work. We are very grateful
to Dr Andrew McMahon, in whose laboratory much of the mutant analysis has been carried
out. Additionally, we would like to thank Ed Sullivan for his help and advice during
the setting-up of a fish facility in the McMahon laboratory. Dr Eric Weinberg generously
supplied us with the myoD cDNA prior to publication. Published reagents were obtained
from Drs Marie-Andrée Akimenko, Jean Stéphane Joly, Stefan Krauss and Stefan Schulte-Merker.
article_processing_charge: No
article_type: original
author:
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Francisco
full_name: Pelegri, Francisco
last_name: Pelegri
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Rachel
full_name: Warga, Rachel
last_name: Warga
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Hammerschmidt M, Pelegri F, Mullins M, et al. Mutations affecting morphogenesis
during gastrulation and tail formation in the zebrafish, Danio rerio. Development.
1996;123(1):143-151. doi:10.1242/dev.123.1.143
apa: Hammerschmidt, M., Pelegri, F., Mullins, M., Kane, D., Brand, M., Van Eeden,
F., … Nüsslein Volhard, C. (1996). Mutations affecting morphogenesis during gastrulation
and tail formation in the zebrafish, Danio rerio. Development. Company
of Biologists. https://doi.org/10.1242/dev.123.1.143
chicago: Hammerschmidt, Matthias, Francisco Pelegri, Mary Mullins, Donald Kane,
Michael Brand, Fredericus Van Eeden, Makoto Furutani Seiki, et al. “Mutations
Affecting Morphogenesis during Gastrulation and Tail Formation in the Zebrafish,
Danio Rerio.” Development. Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.143.
ieee: M. Hammerschmidt et al., “Mutations affecting morphogenesis during
gastrulation and tail formation in the zebrafish, Danio rerio,” Development,
vol. 123, no. 1. Company of Biologists, pp. 143–151, 1996.
ista: Hammerschmidt M, Pelegri F, Mullins M, Kane D, Brand M, Van Eeden F, Furutani
Seiki M, Granato M, Haffter P, Heisenberg C-PJ, Jiang Y, Kelsh R, Odenthal J,
Warga R, Nüsslein Volhard C. 1996. Mutations affecting morphogenesis during gastrulation
and tail formation in the zebrafish, Danio rerio. Development. 123(1), 143–151.
mla: Hammerschmidt, Matthias, et al. “Mutations Affecting Morphogenesis during Gastrulation
and Tail Formation in the Zebrafish, Danio Rerio.” Development, vol. 123,
no. 1, Company of Biologists, 1996, pp. 143–51, doi:10.1242/dev.123.1.143.
short: M. Hammerschmidt, F. Pelegri, M. Mullins, D. Kane, M. Brand, F. Van Eeden,
M. Furutani Seiki, M. Granato, P. Haffter, C.-P.J. Heisenberg, Y. Jiang, R. Kelsh,
J. Odenthal, R. Warga, C. Nüsslein Volhard, Development 123 (1996) 143–151.
date_created: 2018-12-11T12:07:35Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-05T06:59:42Z
day: '01'
doi: 10.1242/dev.123.1.143
extern: '1'
external_id:
pmid:
- '9007236'
intvolume: ' 123'
issue: '1'
language:
- iso: eng
month: '12'
oa_version: None
page: 143 - 151
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1908'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mutations affecting morphogenesis during gastrulation and tail formation in
the zebrafish, Danio rerio
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4210'
abstract:
- lang: eng
text: Mutations causing a visible phenotype in the adult serve as valuable visible
genetic markers in multicellular genetic model organisms such as Drosophila melanogaster,
Caenorhabditis elegans and Arabidopsis thaliana. In a large scale screen for mutations
affecting early development of the zebrafish, we identified a number of mutations
that are homozygous viable or semiviable. Here we describe viable mutations which
produce visible phenotypes in the adult fish. These predominantly affect the fins
and pigmentation, but also the eyes and body length of the adult. A number of
dominant mutations caused visible phenotypes in the adult fish, Mutations in three
genes, long fin, another long fin and wanda affected fin formation in the adult.
Four mutations were found to cause a dominant reduction of the overall body length
in the adult. The adult pigment pattern was found to be changed by dominant mutations
in wanda, asterix, obelix, leopard, salz and pfeffer. Among the recessive mutations
producing visible phenotypes in the homozygous adult, a group of mutations that
failed to produce melanin was assayed for tyrosinase activity. Mutations in sandy
produced embryos that failed to express tyrosinase activity. These are potentially
useful for using tyrosinase as a marker for the generation of transgenic lines
of zebrafish.
article_processing_charge: No
article_type: original
author:
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Shuo
full_name: Lin, Shuo
last_name: Lin
- first_name: Michael
full_name: Farrell, Michael
last_name: Farrell
- first_name: Elisabeth
full_name: Vogelsang, Elisabeth
last_name: Vogelsang
- first_name: Fabian
full_name: Haas, Fabian
last_name: Haas
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Nancy
full_name: Hopkins, Nancy
last_name: Hopkins
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Haffter P, Odenthal J, Mullins M, et al. Mutations affecting pigmentation and
shape of the adult zebrafish. Development Genes and Evolution. 1996;206(4):260-276.
doi:10.1007/s004270050051
apa: Haffter, P., Odenthal, J., Mullins, M., Lin, S., Farrell, M., Vogelsang, E.,
… Nüsslein Volhard, C. (1996). Mutations affecting pigmentation and shape of the
adult zebrafish. Development Genes and Evolution. Springer. https://doi.org/10.1007/s004270050051
chicago: Haffter, Pascal, Jörg Odenthal, Mary Mullins, Shuo Lin, Michael Farrell,
Elisabeth Vogelsang, Fabian Haas, et al. “Mutations Affecting Pigmentation and
Shape of the Adult Zebrafish.” Development Genes and Evolution. Springer,
1996. https://doi.org/10.1007/s004270050051.
ieee: P. Haffter et al., “Mutations affecting pigmentation and shape of the
adult zebrafish,” Development Genes and Evolution, vol. 206, no. 4. Springer,
pp. 260–276, 1996.
ista: Haffter P, Odenthal J, Mullins M, Lin S, Farrell M, Vogelsang E, Haas F, Brand
M, Van Eeden F, Furutani Seiki M, Granato M, Hammerschmidt M, Heisenberg C-PJ,
Jiang Y, Kane D, Kelsh R, Hopkins N, Nüsslein Volhard C. 1996. Mutations affecting
pigmentation and shape of the adult zebrafish. Development Genes and Evolution.
206(4), 260–276.
mla: Haffter, Pascal, et al. “Mutations Affecting Pigmentation and Shape of the
Adult Zebrafish.” Development Genes and Evolution, vol. 206, no. 4, Springer,
1996, pp. 260–76, doi:10.1007/s004270050051.
short: P. Haffter, J. Odenthal, M. Mullins, S. Lin, M. Farrell, E. Vogelsang, F.
Haas, M. Brand, F. Van Eeden, M. Furutani Seiki, M. Granato, M. Hammerschmidt,
C.-P.J. Heisenberg, Y. Jiang, D. Kane, R. Kelsh, N. Hopkins, C. Nüsslein Volhard,
Development Genes and Evolution 206 (1996) 260–276.
date_created: 2018-12-11T12:07:36Z
date_published: 1996-11-27T00:00:00Z
date_updated: 2022-08-04T14:45:21Z
day: '27'
doi: 10.1007/s004270050051
extern: '1'
external_id:
pmid:
- '24173565'
intvolume: ' 206'
issue: '4'
language:
- iso: eng
month: '11'
oa_version: None
page: 260 - 276
pmid: 1
publication: Development Genes and Evolution
publication_identifier:
issn:
- 0043-5546
publication_status: published
publisher: Springer
publist_id: '1906'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mutations affecting pigmentation and shape of the adult zebrafish
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 206
year: '1996'
...
---
_id: '4211'
abstract:
- lang: eng
text: We describe two genes, dino and mercedes, which are required for the organization
of the zebrafish body plan, In dine mutant embryos, the tail is enlarged at the
expense of the head and the anterior region of the trunk, The altered expression
patterns of various marker genes reveal that, with the exception of the dorsal
most marginal zone, all regions of the early dine mutant embryo acquire more ventral
fates, These alterations are already apparent before the onset of gastrulation,
mercedes mutant embryos show a similar but weaker phenotype, suggesting a role
in the same patterning processes. The phenotypes suggests that dine and mercedes
are required for the establishment of dorsal fates in both the marginal and the
animal zone of the early gastrula embryo, Their function in the patterning of
the ventrolateral mesoderm and the induction of the neuroectoderm is similar to
the function of the Spemann organizer in the amphibian embryo.
acknowledgement: "We are very grateful to Dr Andrew McMahon in whose laboratory much
of the mutant analysis has been carried out. Additionally, we would like to thank
Ed Sullivan for his help and advice during the setting up of a fish facility in
the McMahon laboratory. Drs Eric Weinberg and Leonard Zon generously supplied us
with reagents prior to publication. Published reagents were obtained from Drs Jon
Graff, Jean-Stéphane Joly, Stefan Krauss and Stefan Schulte-Merker.\r\nDrs Mary
Dickinson, Andrew McMahon, Siegfried Roth and Stefan Schulte-Merker read earlier
versions of the Manuscript. "
article_processing_charge: No
article_type: original
author:
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Francisco
full_name: Pelegri, Francisco
last_name: Pelegri
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Rachel
full_name: Warga, Rachel
last_name: Warga
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Hammerschmidt M, Pelegri F, Mullins M, et al. Dino and Mercedes, two genes
regulating dorsal development in the zebrafish embryo. Development. 1996;123(1):95-102.
doi:10.1242/dev.123.1.95
apa: Hammerschmidt, M., Pelegri, F., Mullins, M., Kane, D., Van Eeden, F., Granato,
M., … Nüsslein Volhard, C. (1996). Dino and Mercedes, two genes regulating dorsal
development in the zebrafish embryo. Development. Company of Biologists.
https://doi.org/10.1242/dev.123.1.95
chicago: Hammerschmidt, Matthias, Francisco Pelegri, Mary Mullins, Donald Kane,
Fredericus Van Eeden, Michael Granato, Michael Brand, et al. “Dino and Mercedes,
Two Genes Regulating Dorsal Development in the Zebrafish Embryo.” Development.
Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.95.
ieee: M. Hammerschmidt et al., “Dino and Mercedes, two genes regulating dorsal
development in the zebrafish embryo,” Development, vol. 123, no. 1. Company
of Biologists, pp. 95–102, 1996.
ista: Hammerschmidt M, Pelegri F, Mullins M, Kane D, Van Eeden F, Granato M, Brand
M, Furutani Seiki M, Haffter P, Heisenberg C-PJ, Jiang Y, Kelsh R, Odenthal J,
Warga R, Nüsslein Volhard C. 1996. Dino and Mercedes, two genes regulating dorsal
development in the zebrafish embryo. Development. 123(1), 95–102.
mla: Hammerschmidt, Matthias, et al. “Dino and Mercedes, Two Genes Regulating Dorsal
Development in the Zebrafish Embryo.” Development, vol. 123, no. 1, Company
of Biologists, 1996, pp. 95–102, doi:10.1242/dev.123.1.95.
short: M. Hammerschmidt, F. Pelegri, M. Mullins, D. Kane, F. Van Eeden, M. Granato,
M. Brand, M. Furutani Seiki, P. Haffter, C.-P.J. Heisenberg, Y. Jiang, R. Kelsh,
J. Odenthal, R. Warga, C. Nüsslein Volhard, Development 123 (1996) 95–102.
date_created: 2018-12-11T12:07:36Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-04T15:10:34Z
day: '01'
doi: 10.1242/dev.123.1.95
extern: '1'
external_id:
pmid:
- '9007232'
intvolume: ' 123'
issue: '1'
language:
- iso: eng
month: '12'
oa_version: None
page: 95 - 102
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1907'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Dino and Mercedes, two genes regulating dorsal development in the zebrafish
embryo
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4292'
abstract:
- lang: eng
text: Ageing, or senescence, is a decline in state at later ages that is manifested
through a reduction in survival and fecundity. Ageing means that reproductive
prospects and hence the life history options (trade-offs) open to the organism
decline. Evolutionary theories of ageing suggest that it evolves in response to
the level of externally imposed mortality and insults to fertility, either as
part of life history optimization or as a result of mutation pressure. Several
recent empirical and theoretical studies have produced apparently anomalous results.
Some have suggested that the rate of ageing can decline at later ages, others
that demographic evidence for ageing can appear in parallel with an improvement
in state. All of these studies used measures of ageing that would not be expected
to give an accurate reflection of changes in the state of the organism with age.
We propose that Fisher's `reproductive value' is a natural measure of state at
each age, which includes prospects for both survival and reproduction. If this
measure is used, the apparently anomalous findings are not at variance with evolutionary
theories of ageing.
article_processing_charge: No
author:
- first_name: Linda
full_name: Partridge, Linda
last_name: Partridge
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Partridge L, Barton NH. On measuring the rate of ageing. Proceedings of
the Royal Society of London Series B Biological Sciences. 1996;263(1375):1365-1371.
doi:10.1098/rspb.1996.0200
apa: Partridge, L., & Barton, N. H. (1996). On measuring the rate of ageing.
Proceedings of the Royal Society of London Series B Biological Sciences.
Royal Society of London. https://doi.org/10.1098/rspb.1996.0200
chicago: Partridge, Linda, and Nicholas H Barton. “On Measuring the Rate of Ageing.”
Proceedings of the Royal Society of London Series B Biological Sciences.
Royal Society of London, 1996. https://doi.org/10.1098/rspb.1996.0200.
ieee: L. Partridge and N. H. Barton, “On measuring the rate of ageing,” Proceedings
of the Royal Society of London Series B Biological Sciences, vol. 263, no.
1375. Royal Society of London, pp. 1365–1371, 1996.
ista: Partridge L, Barton NH. 1996. On measuring the rate of ageing. Proceedings
of the Royal Society of London Series B Biological Sciences. 263(1375), 1365–1371.
mla: Partridge, Linda, and Nicholas H. Barton. “On Measuring the Rate of Ageing.”
Proceedings of the Royal Society of London Series B Biological Sciences,
vol. 263, no. 1375, Royal Society of London, 1996, pp. 1365–71, doi:10.1098/rspb.1996.0200.
short: L. Partridge, N.H. Barton, Proceedings of the Royal Society of London Series
B Biological Sciences 263 (1996) 1365–1371.
date_created: 2018-12-11T12:08:05Z
date_published: 1996-10-22T00:00:00Z
date_updated: 2022-07-04T12:59:56Z
day: '22'
doi: 10.1098/rspb.1996.0200
extern: '1'
intvolume: ' 263'
issue: '1375'
language:
- iso: eng
main_file_link:
- url: https://royalsocietypublishing.org/doi/abs/10.1098/rspb.1996.0200
month: '10'
oa_version: None
page: 1365 - 1371
publication: Proceedings of the Royal Society of London Series B Biological Sciences
publication_identifier:
issn:
- 0950-1193
publication_status: published
publisher: Royal Society of London
publist_id: '1786'
quality_controlled: '1'
status: public
title: On measuring the rate of ageing
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 263
year: '1996'
...
---
_id: '3462'
article_processing_charge: No
article_type: original
author:
- first_name: Thorsten
full_name: Melcher, Thorsten
last_name: Melcher
- first_name: Jörg
full_name: Geiger, Jörg
last_name: Geiger
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Hannah
full_name: Monyer, Hannah
last_name: Monyer
citation:
ama: Melcher T, Geiger J, Jonas PM, Monyer H. Analysis of molecular determinants
in native AMPA receptors. Neurochemistry International. 1996;28(2):141-144.
doi:10.1016/0197-0186(95)00077-1
apa: Melcher, T., Geiger, J., Jonas, P. M., & Monyer, H. (1996). Analysis of
molecular determinants in native AMPA receptors. Neurochemistry International.
Elsevier. https://doi.org/10.1016/0197-0186(95)00077-1
chicago: Melcher, Thorsten, Jörg Geiger, Peter M Jonas, and Hannah Monyer. “Analysis
of Molecular Determinants in Native AMPA Receptors.” Neurochemistry International.
Elsevier, 1996. https://doi.org/10.1016/0197-0186(95)00077-1.
ieee: T. Melcher, J. Geiger, P. M. Jonas, and H. Monyer, “Analysis of molecular
determinants in native AMPA receptors,” Neurochemistry International, vol.
28, no. 2. Elsevier, pp. 141–144, 1996.
ista: Melcher T, Geiger J, Jonas PM, Monyer H. 1996. Analysis of molecular determinants
in native AMPA receptors. Neurochemistry International. 28(2), 141–144.
mla: Melcher, Thorsten, et al. “Analysis of Molecular Determinants in Native AMPA
Receptors.” Neurochemistry International, vol. 28, no. 2, Elsevier, 1996,
pp. 141–44, doi:10.1016/0197-0186(95)00077-1.
short: T. Melcher, J. Geiger, P.M. Jonas, H. Monyer, Neurochemistry International
28 (1996) 141–144.
date_created: 2018-12-11T12:03:27Z
date_published: 1996-02-01T00:00:00Z
date_updated: 2022-08-11T09:42:29Z
day: '01'
doi: 10.1016/0197-0186(95)00077-1
extern: '1'
external_id:
pmid:
- '8719701 '
intvolume: ' 28'
issue: '2'
language:
- iso: eng
month: '02'
oa_version: None
page: 141 - 144
pmid: 1
publication: Neurochemistry International
publication_identifier:
issn:
- 0197-0186
publication_status: published
publisher: Elsevier
publist_id: '2925'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Analysis of molecular determinants in native AMPA receptors
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 28
year: '1996'
...
---
_id: '3756'
abstract:
- lang: eng
text: 'In many eukaryotic cells going through M-phase, a bipolar spindle is formed
by microtubules nucleated from centrosomes. These microtubules, in addition to
being `''captured” by kinetochores, may be stabilized by chromatin in two different
ways: short-range stabilization effects may affect microtubules in close contact
with the chromatin, while long-range stabilization effects may `''guide” microtubule
growth towards the chromatin (e.g., by introducing a diffusive gradient of an
enzymatic activity that affects microtubule assembly). Here, we use both meiotic
and mitotic extracts from Xenopus laevis eggs to study microtubule aster formation
and microtubule dynamics in the presence of chromatin. In `''low-speed” meiotic
extracts, in the presence of salmon sperm chromatin, we find that short-range
stabilization effects lead to a strong anisotropy of the microtubule asters. Analysis
of the dynamic parameters of microtubule growth shows that this anisotropy arises
from a decrease in the catastrophe frequency, an increase in the rescue frequency
and a decrease in the growth velocity. In this system we also find evidence for
long-range `''guidance” effects, which lead to a weak anisotropy of the asters.
Statistically relevant results on these long-range effects are obtained in `''high-speed”
mitotic extracts in the presence of artificially constructed chromatin stripes.
We find that aster anisotropy is biased in the direction of the chromatin and
that the catastrophe frequency is reduced in its vicinity. In this system we also
find a surprising dependence of the catastrophe and the rescue frequencies on
the length of microtubules nucleated from centrosomes: the catastrophe frequency
increases and the rescue frequency decreases with microtubule length.'
acknowledgement: "We would like to thank T. Holy and T. Mitchison for providing us
with centrosomes; M. Glotzer and T. Mitchison for giving us the plasmid for A90
cyclin B; J. Stock and members of his laboratory for help with biochemical preparations;
R. Zimmerman for help with the biotinylation of DNA; J. Shepard for help with the
patterning of surfaces; D. Tsui for use\r\nof his clean room facility, and D. Fygenson,
T. Holy, E. Karsenti, E. Kennedy, A. Levine, T. Mitchison, and G. Waters for valuable
discussions, constant encouragement and technical help. This work was partially
supported by the National Institutes of Health (Grant No. GM-50712) and the Human
Frontier Science Program."
article_processing_charge: No
article_type: original
author:
- first_name: Marileen
full_name: Dogterom, Marileen
last_name: Dogterom
- first_name: M.
full_name: Felix, M.
last_name: Felix
- first_name: Calin C
full_name: Guet, Calin C
id: 47F8433E-F248-11E8-B48F-1D18A9856A87
last_name: Guet
orcid: 0000-0001-6220-2052
- first_name: Stanislas
full_name: Leibler, Stanislas
last_name: Leibler
citation:
ama: 'Dogterom M, Felix M, Guet CC, Leibler S. Influence of M-phase chromatin on
the anisotropy of microtubule asters. Journal of Cell Biology. 1996;133(1):125-140.
doi:doi: 10.1083/jcb.133.1.125
'
apa: 'Dogterom, M., Felix, M., Guet, C. C., & Leibler, S. (1996). Influence
of M-phase chromatin on the anisotropy of microtubule asters. Journal of Cell
Biology. Rockefeller University Press. https://doi.org/doi: 10.1083/jcb.133.1.125 '
chicago: 'Dogterom, Marileen, M. Felix, Calin C Guet, and Stanislas Leibler. “Influence
of M-Phase Chromatin on the Anisotropy of Microtubule Asters.” Journal of Cell
Biology. Rockefeller University Press, 1996. https://doi.org/doi: 10.1083/jcb.133.1.125 .'
ieee: M. Dogterom, M. Felix, C. C. Guet, and S. Leibler, “Influence of M-phase chromatin
on the anisotropy of microtubule asters,” Journal of Cell Biology, vol.
133, no. 1. Rockefeller University Press, pp. 125–140, 1996.
ista: Dogterom M, Felix M, Guet CC, Leibler S. 1996. Influence of M-phase chromatin
on the anisotropy of microtubule asters. Journal of Cell Biology. 133(1), 125–140.
mla: 'Dogterom, Marileen, et al. “Influence of M-Phase Chromatin on the Anisotropy
of Microtubule Asters.” Journal of Cell Biology, vol. 133, no. 1, Rockefeller
University Press, 1996, pp. 125–40, doi:doi: 10.1083/jcb.133.1.125 .'
short: M. Dogterom, M. Felix, C.C. Guet, S. Leibler, Journal of Cell Biology 133
(1996) 125–140.
date_created: 2018-12-11T12:05:00Z
date_published: 1996-01-01T00:00:00Z
date_updated: 2022-08-09T14:20:13Z
day: '01'
doi: 'doi: 10.1083/jcb.133.1.125 '
extern: '1'
external_id:
pmid:
- '8601601'
intvolume: ' 133'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2120784/
month: '01'
oa: 1
oa_version: Published Version
page: 125 - 140
pmid: 1
publication: Journal of Cell Biology
publication_identifier:
issn:
- 0021-9525
publication_status: published
publisher: Rockefeller University Press
publist_id: '2473'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Influence of M-phase chromatin on the anisotropy of microtubule asters
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 133
year: '1996'
...
---
_id: '4027'
abstract:
- lang: eng
text: 'Questions about lines in space arise frequently as subproblems in three-dimensional
computational geometry. In this paper we study a number of fundamental combinatorial
and algorithmic problems involving arrangements of n lines in three-dimensional
space. Our main results include: 1. A tight Θ(n2) bound on the maximum combinatorial
description complexity of the set of all oriented lines that have specified orientations
relative to the n given lines. 2. A similar bound of Θ(n3) for the complexity
of the set of all lines passing above the n given lines. 3. A preprocessing procedure
using O(n2+ε) time and storage, for any ε > 0, that builds a structure supporting
O(logn)-time queries for testing if a line lies above all the given lines. 4.
An algorithm that tests the "towering property" in O(n4/3+ε) time, for
any ε > 0: do n given red lines lie all above n given blue lines? The tools
used to obtain these and other results include Plücker coordinates for lines in
space and ε-nets for various geometric range spaces.'
acknowledgement: Work on this paper by Bernard Chazelle has been supported by NSF
Grant CCR-87-00917. Work on this paper by Herbert Edelsbrunner has been supported
by NSF Grant CCR-87-14565. Work on this paper by Leonidas Guibas has been supported
by grants from the Mitsubishi and Toshiba Corporations. Work on this paper by Micha
Sharir has been supported by ONR Grant N00014-87-K-0129, by NSF Grants DCR-83-20085
and CCR-89-01484, and by grants from the U.S.-Israeli Binational Science Foundation,
the NCRD — the Israeli National Council for Research and Development, and the EMET
Fund of the Israeli Academy of Sciences.
article_processing_charge: No
article_type: original
author:
- first_name: Bernard
full_name: Chazelle, Bernard
last_name: Chazelle
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Leonidas
full_name: Guibas, Leonidas
last_name: Guibas
- first_name: Micha
full_name: Sharir, Micha
last_name: Sharir
- first_name: Jorge
full_name: Stolfi, Jorge
last_name: Stolfi
citation:
ama: 'Chazelle B, Edelsbrunner H, Guibas L, Sharir M, Stolfi J. Lines in space:
Combinatorics and algorithms. Algorithmica. 1996;15(5):428-447. doi:10.1007/BF01955043'
apa: 'Chazelle, B., Edelsbrunner, H., Guibas, L., Sharir, M., & Stolfi, J. (1996).
Lines in space: Combinatorics and algorithms. Algorithmica. Springer. https://doi.org/10.1007/BF01955043'
chicago: 'Chazelle, Bernard, Herbert Edelsbrunner, Leonidas Guibas, Micha Sharir,
and Jorge Stolfi. “Lines in Space: Combinatorics and Algorithms.” Algorithmica.
Springer, 1996. https://doi.org/10.1007/BF01955043.'
ieee: 'B. Chazelle, H. Edelsbrunner, L. Guibas, M. Sharir, and J. Stolfi, “Lines
in space: Combinatorics and algorithms,” Algorithmica, vol. 15, no. 5.
Springer, pp. 428–447, 1996.'
ista: 'Chazelle B, Edelsbrunner H, Guibas L, Sharir M, Stolfi J. 1996. Lines in
space: Combinatorics and algorithms. Algorithmica. 15(5), 428–447.'
mla: 'Chazelle, Bernard, et al. “Lines in Space: Combinatorics and Algorithms.”
Algorithmica, vol. 15, no. 5, Springer, 1996, pp. 428–47, doi:10.1007/BF01955043.'
short: B. Chazelle, H. Edelsbrunner, L. Guibas, M. Sharir, J. Stolfi, Algorithmica
15 (1996) 428–447.
date_created: 2018-12-11T12:06:31Z
date_published: 1996-05-01T00:00:00Z
date_updated: 2022-08-09T09:55:46Z
day: '01'
doi: 10.1007/BF01955043
extern: '1'
intvolume: ' 15'
issue: '5'
language:
- iso: eng
month: '05'
oa_version: None
page: 428 - 447
publication: Algorithmica
publication_identifier:
issn:
- 0178-4617
publication_status: published
publisher: Springer
publist_id: '2100'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Lines in space: Combinatorics and algorithms'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 15
year: '1996'
...
---
_id: '4026'
abstract:
- lang: eng
text: A set of n weighted points in general position in R(d) defines a unique regular
triangulation. This paper proves that if the points are added one by one, then
flipping in a topological order will succeed in constructing this triangulation.
If, in addition, the points are added in a random sequence and the history of
the flips is used for locating the next point, then the algorithm takes expected
time at most O(n log n + n(inverted left perpendicular d/2 inverted right perpendicular)).
Under the assumption that the points and weights are independently and identically
distributed, the expected running time is between proportional to and a factor
log n more than the expected size of the regular triangulation. The expectation
is over choosing the points and over independent coin-flips performed by the algorithm.
acknowledgement: National Science Foundation under Grant CCR-8921421, Alan T. Waterman
award, Grant CCR-9118874.
article_processing_charge: No
article_type: original
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Nimish
full_name: Shah, Nimish
last_name: Shah
citation:
ama: Edelsbrunner H, Shah N. Incremental topological flipping works for regular
triangulations. Algorithmica. 1996;15(3):223-241. doi:10.1007/BF01975867
apa: Edelsbrunner, H., & Shah, N. (1996). Incremental topological flipping works
for regular triangulations. Algorithmica. Springer. https://doi.org/10.1007/BF01975867
chicago: Edelsbrunner, Herbert, and Nimish Shah. “Incremental Topological Flipping
Works for Regular Triangulations.” Algorithmica. Springer, 1996. https://doi.org/10.1007/BF01975867.
ieee: H. Edelsbrunner and N. Shah, “Incremental topological flipping works for regular
triangulations,” Algorithmica, vol. 15, no. 3. Springer, pp. 223–241, 1996.
ista: Edelsbrunner H, Shah N. 1996. Incremental topological flipping works for regular
triangulations. Algorithmica. 15(3), 223–241.
mla: Edelsbrunner, Herbert, and Nimish Shah. “Incremental Topological Flipping Works
for Regular Triangulations.” Algorithmica, vol. 15, no. 3, Springer, 1996,
pp. 223–41, doi:10.1007/BF01975867.
short: H. Edelsbrunner, N. Shah, Algorithmica 15 (1996) 223–241.
date_created: 2018-12-11T12:06:31Z
date_published: 1996-03-01T00:00:00Z
date_updated: 2022-08-09T09:46:07Z
day: '01'
doi: 10.1007/BF01975867
extern: '1'
intvolume: ' 15'
issue: '3'
language:
- iso: eng
month: '03'
oa_version: None
page: 223 - 241
publication: Algorithmica
publication_identifier:
issn:
- 0178-4617
publication_status: published
publisher: Springer
publist_id: '2099'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Incremental topological flipping works for regular triangulations
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 15
year: '1996'
...
---
_id: '4030'
acknowledgement: article M-Pos412
article_processing_charge: No
author:
- first_name: Jie
full_name: Liang, Jie
last_name: Liang
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Shankar
full_name: Subramaniam, Shankar
last_name: Subramaniam
citation:
ama: Liang J, Edelsbrunner H, Subramaniam S. Effects of Molecular Shape Representations
on Boundary Element Method for Protein Electrostatics Computations. Vol 70.
Cell Press; 1996:A224-A224. doi:10.1016/S0006-3495(96)79664-9
apa: Liang, J., Edelsbrunner, H., & Subramaniam, S. (1996). Effects of molecular
shape representations on boundary element method for protein electrostatics computations.
Fortieth Annual Meeting (Vol. 70, pp. A224–A224). Cell Press. https://doi.org/10.1016/S0006-3495(96)79664-9
chicago: Liang, Jie, Herbert Edelsbrunner, and Shankar Subramaniam. Effects of
Molecular Shape Representations on Boundary Element Method for Protein Electrostatics
Computations. Fortieth Annual Meeting. Vol. 70. Cell Press, 1996. https://doi.org/10.1016/S0006-3495(96)79664-9.
ieee: J. Liang, H. Edelsbrunner, and S. Subramaniam, Effects of molecular shape
representations on boundary element method for protein electrostatics computations,
vol. 70, no. 2, Part 2. Cell Press, 1996, pp. A224–A224.
ista: Liang J, Edelsbrunner H, Subramaniam S. 1996. Effects of molecular shape representations
on boundary element method for protein electrostatics computations, Cell Press,p.
mla: Liang, Jie, et al. “Effects of Molecular Shape Representations on Boundary
Element Method for Protein Electrostatics Computations.” Fortieth Annual Meeting,
vol. 70, no. 2, Part 2, Cell Press, 1996, pp. A224–A224, doi:10.1016/S0006-3495(96)79664-9.
short: J. Liang, H. Edelsbrunner, S. Subramaniam, Effects of Molecular Shape Representations
on Boundary Element Method for Protein Electrostatics Computations, Cell Press,
1996.
date_created: 2018-12-11T12:06:32Z
date_published: 1996-02-19T00:00:00Z
date_updated: 2022-08-08T10:22:38Z
day: '19'
doi: 10.1016/S0006-3495(96)79664-9
extern: '1'
intvolume: ' 70'
issue: 2, Part 2
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/S0006349596796649?via%3Dihub
month: '02'
oa: 1
oa_version: None
page: A224 - A224
publication: Fortieth Annual Meeting
publication_status: published
publisher: Cell Press
publist_id: '2097'
status: public
title: Effects of molecular shape representations on boundary element method for protein
electrostatics computations
type: conference_poster
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 70
year: '1996'
...
---
_id: '4031'
acknowledgement: article W-AM-L6
article_processing_charge: No
author:
- first_name: Jie
full_name: Liang, Jie
last_name: Liang
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Sudhakar
full_name: Pamidghantam, Sudhakar
last_name: Pamidghantam
- first_name: Shankar
full_name: Subramaniam, Shankar
last_name: Subramaniam
citation:
ama: 'Liang J, Edelsbrunner H, Pamidghantam S, Subramaniam S. Analytical Method
for Molecular Shapes: Area, Volume, Cavities, Interface and Pockets. Vol 70.
Cell Press; 1996:A377-A377. doi:10.1016/S0006-3495(96)79670-4'
apa: 'Liang, J., Edelsbrunner, H., Pamidghantam, S., & Subramaniam, S. (1996).
Analytical method for molecular shapes: Area, volume, cavities, interface and
pockets. Fortieth Annual Meeting (Vol. 70, pp. A377–A377). Cell Press.
https://doi.org/10.1016/S0006-3495(96)79670-4'
chicago: 'Liang, Jie, Herbert Edelsbrunner, Sudhakar Pamidghantam, and Shankar Subramaniam.
Analytical Method for Molecular Shapes: Area, Volume, Cavities, Interface and
Pockets. Fortieth Annual Meeting. Vol. 70. Cell Press, 1996. https://doi.org/10.1016/S0006-3495(96)79670-4.'
ieee: 'J. Liang, H. Edelsbrunner, S. Pamidghantam, and S. Subramaniam, Analytical
method for molecular shapes: Area, volume, cavities, interface and pockets,
vol. 70, no. 2, Part 2. Cell Press, 1996, pp. A377–A377.'
ista: 'Liang J, Edelsbrunner H, Pamidghantam S, Subramaniam S. 1996. Analytical
method for molecular shapes: Area, volume, cavities, interface and pockets, Cell
Press,p.'
mla: 'Liang, Jie, et al. “Analytical Method for Molecular Shapes: Area, Volume,
Cavities, Interface and Pockets.” Fortieth Annual Meeting, vol. 70, no.
2, Part 2, Cell Press, 1996, pp. A377–A377, doi:10.1016/S0006-3495(96)79670-4.'
short: 'J. Liang, H. Edelsbrunner, S. Pamidghantam, S. Subramaniam, Analytical Method
for Molecular Shapes: Area, Volume, Cavities, Interface and Pockets, Cell Press,
1996.'
date_created: 2018-12-11T12:06:32Z
date_published: 1996-02-21T00:00:00Z
date_updated: 2022-08-08T10:21:56Z
day: '21'
doi: 10.1016/S0006-3495(96)79670-4
extern: '1'
intvolume: ' 70'
issue: 2, Part 2
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/S0006349596796704?via%3Dihub
month: '02'
oa: 1
oa_version: None
page: A377 - A377
publication: Fortieth Annual Meeting
publication_status: published
publisher: Cell Press
publist_id: '2098'
status: public
title: 'Analytical method for molecular shapes: Area, volume, cavities, interface
and pockets'
type: conference_poster
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 70
year: '1996'
...
---
_id: '4142'
abstract:
- lang: eng
text: 'Mutations giving rise to anatomical defects in the inner ear have been isolated
in a large scale screen for mutations causing visible abnormalities in the zebrafish
embryo (Haffter, P., Granato, M., Brand, M. et al. (1996) Development 123, 1-36).
58 mutants have been classified as having a primary ear phenotype; these fall
into several phenotypic classes, affecting presence or size of the otoliths, size
and shape of the otic vesicle and formation of the semicircular canals, and define
at least 20 complementation groups. Mutations in seven genes cause loss of one
or both otoliths, but do not appear to affect development of other structures
within the ear. Mutations in seven genes affect morphology and patterning of the
inner ear epithelium, including formation of the semicircular canals and, in some,
development of sensory patches (maculae and cristae). Within this class, dog-eared
mutants show abnormal development of semicircular canals and lack cristae within
the ear, while in van gogh, semicircular canals fail to form altogether, resulting
in a tiny otic vesicle containing a single sensory patch. Both these mutants show
defects in the expression of homeobox genes within the otic vesicle. In a further
class of mutants, ear size is affected while patterning appears to be relatively
normal; mutations in three genes cause expansion of the otic vesicle, while in
little ears and microtic, the ear is abnormally small, but still contains all
five sensory patches, as in the wild type. Many of the ear and otolith mutants
show an expected behavioural phenotype: embryos fail to balance correctly, and
may swim on their sides, upside down, or in circles. Several mutants with similar
balance defects have also been isolated that have no obvious structural ear defect,
but that may include mutants with vestibular dysfunction of the inner ear (Granato,
M., van Eeden, F. J. M., Schach, U. et al. (1996) Development, 123, 399-413,).
Mutations in 19 genes causing primary defects in other structures also show an
ear defect. In particular, ear phenotypes are often found in conjunction with
defects of neural crest derivatives (pigment cells and/or cartilaginous elements
of the jaw). At least one mutant, dog-eared, shows defects in both the ear and
another placodally derived sensory system, the lateral line, while hypersensitive
mutants have additional trunk lateral line organs.'
acknowledgement: T. T. W. thanks all members of the Tübingen fish and fly groups for
their hospitality and generosity during her visits to the laboratory. We thank Julian
Lewis, in whose laboratory much of this work was carried out, for many helpful discussions
and suggestions, Catherine Haddon for advice on wild-type ear development and techniques,
and Stephen Massey for fish husbandry in Oxford. We are grateful to Julian Lewis,
Catherine Haddon, Nick Monk and Patrick Blader for comments on the manuscript, and
to Trevor Jowett, Tom Schilling,Eric Weinberg and Monte Westerfield for providing
cDNAs. We also thank Jarema Malicki and Wolfgang Driever for making some of the
Boston otolith mutants available before publication. T. T. W. thanks the EMBO (ASTF
7668; ASTF 7918), the Imperial Cancer Research Fund and the Wellcome Trust (03643/Z/92)
for support.
article_processing_charge: No
article_type: original
author:
- first_name: Tanya
full_name: Whitfield, Tanya
last_name: Whitfield
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Ursula
full_name: Schach, Ursula
last_name: Schach
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Whitfield T, Granato M, Van Eeden F, et al. Mutations affecting development
of the zebrafish inner ear and lateral line. Development. 1996;123:241-254.
doi:10.1242/dev.123.1.241
apa: Whitfield, T., Granato, M., Van Eeden, F., Schach, U., Brand, M., Furutani
Seiki, M., … Nüsslein Volhard, C. (1996). Mutations affecting development of the
zebrafish inner ear and lateral line. Development. Company of Biologists.
https://doi.org/10.1242/dev.123.1.241
chicago: Whitfield, Tanya, Michael Granato, Fredericus Van Eeden, Ursula Schach,
Michael Brand, Makoto Furutani Seiki, Pascal Haffter, et al. “Mutations Affecting
Development of the Zebrafish Inner Ear and Lateral Line.” Development.
Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.241.
ieee: T. Whitfield et al., “Mutations affecting development of the zebrafish
inner ear and lateral line,” Development, vol. 123. Company of Biologists,
pp. 241–254, 1996.
ista: Whitfield T, Granato M, Van Eeden F, Schach U, Brand M, Furutani Seiki M,
Haffter P, Hammerschmidt M, Heisenberg C-PJ, Jiang Y, Kane D, Kelsh R, Mullins
M, Odenthal J, Nüsslein Volhard C. 1996. Mutations affecting development of the
zebrafish inner ear and lateral line. Development. 123, 241–254.
mla: Whitfield, Tanya, et al. “Mutations Affecting Development of the Zebrafish
Inner Ear and Lateral Line.” Development, vol. 123, Company of Biologists,
1996, pp. 241–54, doi:10.1242/dev.123.1.241.
short: T. Whitfield, M. Granato, F. Van Eeden, U. Schach, M. Brand, M. Furutani
Seiki, P. Haffter, M. Hammerschmidt, C.-P.J. Heisenberg, Y. Jiang, D. Kane, R.
Kelsh, M. Mullins, J. Odenthal, C. Nüsslein Volhard, Development 123 (1996) 241–254.
date_created: 2018-12-11T12:07:11Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-08T08:45:59Z
day: '01'
doi: 10.1242/dev.123.1.241
extern: '1'
external_id:
pmid:
- '9007244'
intvolume: ' 123'
language:
- iso: eng
month: '12'
oa_version: None
page: 241 - 254
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1979'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mutations affecting development of the zebrafish inner ear and lateral line
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4154'
abstract:
- lang: eng
text: As part of a large scale chemical mutagenesis screen of the zebrafish (Danio
rerio) genome, we have identified 33 mutants with defects in hematopoiesis, Complementation
analysis placed 32 of these mutants into 17 complementation groups, The allelism
of the remaining 1 blood mutant is currently unresolved, We have categorized these
blood mutants into four phenotypic classes based on analyses of whole embryos
and isolated blood cells, as well as by in situ hybridization using the hematopoietic
transcription factors GATA-1 and GATA-2, Embryos mutant for the gene moonshine
have few if any proerythroblasts visible on the day circulation begins and normal
erythroid cell differentiation is blocked as determined by staining for hemoglobin
and GATA-1 expression, Mutations in five genes, chablis, frascati, merlot, retsina,
thunderbird and two possibly unique mutations cause a progressive decrease in
the number of blood cells during the first 5 days of development, Mutations in
another seven genes, chardonnay, chianti, grenache, sauternes, weibherbst and
zinfandel, and two additional mutations result in hypochromic blood cells which
also decrease in number as development proceeds, Several of these mutants have
immature cells in the circulation, indicating a block in normal erythroid development.
The mutation in zinfandel is dominant, and 2-day old heterozygous carriers fail
to express detectable levels of hemoglobin and have decreasing numbers of circulating
cells during the first 5 days of development, Mutations in two genes, freixenet
and yquem, result in the animals that are photosensitive with autofluorescent
blood, similar to that found in the human congenital porphyrias, The collection
of mutants presented here represent several steps required for normal erythropoiesis,
The analysis of these mutants provides a powerful approach towards defining the
molecular mechanisms involved in vertebrate hematopoietic development.
acknowledgement: 'We thank Leonard Zon for his generous support of D. G. R. and A.
B., for critical review of this manuscript and for many helpful discussions. We
also thank Lauren Barone and Stephen Pratt for technical assistance. D. G. R. is
a postdoctoral fellow of the Howard Hughes Medical Institute. '
article_processing_charge: No
article_type: original
author:
- first_name: David
full_name: Ransom, David
last_name: Ransom
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Alison
full_name: Brownlie, Alison
last_name: Brownlie
- first_name: Elisabeth
full_name: Vogelsang, Elisabeth
last_name: Vogelsang
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Ransom D, Haffter P, Odenthal J, et al. Characterization of zebrafish mutants
with defects in embryonic hematopoiesis. Development. 1996;123(1):311-319.
doi:10.1242/dev.123.1.311
apa: Ransom, D., Haffter, P., Odenthal, J., Brownlie, A., Vogelsang, E., Kelsh,
R., … Nüsslein Volhard, C. (1996). Characterization of zebrafish mutants with
defects in embryonic hematopoiesis. Development. Company of Biologists.
https://doi.org/10.1242/dev.123.1.311
chicago: Ransom, David, Pascal Haffter, Jörg Odenthal, Alison Brownlie, Elisabeth
Vogelsang, Robert Kelsh, Michael Brand, et al. “Characterization of Zebrafish
Mutants with Defects in Embryonic Hematopoiesis.” Development. Company
of Biologists, 1996. https://doi.org/10.1242/dev.123.1.311.
ieee: D. Ransom et al., “Characterization of zebrafish mutants with defects
in embryonic hematopoiesis,” Development, vol. 123, no. 1. Company of Biologists,
pp. 311–319, 1996.
ista: Ransom D, Haffter P, Odenthal J, Brownlie A, Vogelsang E, Kelsh R, Brand M,
Van Eeden F, Furutani Seiki M, Granato M, Hammerschmidt M, Heisenberg C-PJ, Jiang
Y, Kane D, Mullins M, Nüsslein Volhard C. 1996. Characterization of zebrafish
mutants with defects in embryonic hematopoiesis. Development. 123(1), 311–319.
mla: Ransom, David, et al. “Characterization of Zebrafish Mutants with Defects in
Embryonic Hematopoiesis.” Development, vol. 123, no. 1, Company of Biologists,
1996, pp. 311–19, doi:10.1242/dev.123.1.311.
short: D. Ransom, P. Haffter, J. Odenthal, A. Brownlie, E. Vogelsang, R. Kelsh,
M. Brand, F. Van Eeden, M. Furutani Seiki, M. Granato, M. Hammerschmidt, C.-P.J.
Heisenberg, Y. Jiang, D. Kane, M. Mullins, C. Nüsslein Volhard, Development 123
(1996) 311–319.
date_created: 2018-12-11T12:07:16Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-08T08:23:35Z
day: '01'
doi: 10.1242/dev.123.1.311
extern: '1'
external_id:
pmid:
- '9007251'
intvolume: ' 123'
issue: '1'
language:
- iso: eng
month: '12'
oa_version: None
page: 311 - 319
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1966'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Characterization of zebrafish mutants with defects in embryonic hematopoiesis
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4156'
abstract:
- lang: eng
text: 'In a large scale screen for mutants that affect the early development of
the zebrafish, 109 mutants were found that cause defects in the formation of the
jaw and the more posterior pharyngeal arches, Here we present the phenotypic description
and results of the complementation analysis of mutants belonging to two major
classes: (1) mutants with defects in the mandibular and hyoid arches and (2) mutants
with defects in cartilage differentiation and growth in all arches, Mutations
in four of the genes identified during the screen show specific defects in the
first two arches and leave the more posterior pharyngeal arches largely unaffected
(schmerle, sucker, hoover and sturgeon). In these mutants ventral components of
the mandibular and hyoid arches are reduced (Meckel''s cartilage and ceratohyal
cartilage) whereas dorsal structures (palato-quadrate and hyosymplectic cartilages)
are of normal size or enlarged, Thus, mutations in single genes cause defects
in the formation of first and second arch structures but also differentially affect
development of the dorsal and ventral structures within one arch. In 27 mutants
that define at least 8 genes, the differentiation of cartilage and growth is affected.
In hammerhead mutants particularly the mesodermally derived cartilages are reduced,
whereas jellyfish mutant larvae are characterized by a severe reduction of all
cartilaginous elements, leaving only two pieces in the position of the ceratohyal
cartilages. In all other mutant larvae all skeletal elements are present, but
consist of smaller and disorganized chondrocytes. These mutants also exhibit shortened
heads and reduced pectoral fins. In homozygous knorrig embryos, tumor-like outgrowths
of chondrocytes occur along the edges of all cartilaginous elements. The mutants
presented here may be valuable tools for elucidating the genetic mechanisms that
underlie the development of the mandibular and the hyoid arches, as well as the
process of cartilage differentiation.'
acknowledgement: We would like to thank Siegfried Roth, Stefan Schulte-Merker and
Tanya Whitfield for critically reading the manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Tatjana
full_name: Piotrowski, Tatjana
last_name: Piotrowski
- first_name: Thomas
full_name: Schilling, Thomas
last_name: Schilling
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Dirk
full_name: Beuchle, Dirk
last_name: Beuchle
- first_name: Heiner
full_name: Grandel, Heiner
last_name: Grandel
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Rachel
full_name: Warga, Rachel
last_name: Warga
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: 'Piotrowski T, Schilling T, Brand M, et al. Jaw and branchial arch mutants
in zebrafish II: Anterior arches and cartilage differentiation. Development.
1996;123(1):345-356. doi:10.1242/dev.123.1.345'
apa: 'Piotrowski, T., Schilling, T., Brand, M., Jiang, Y., Heisenberg, C.-P. J.,
Beuchle, D., … Nüsslein Volhard, C. (1996). Jaw and branchial arch mutants in
zebrafish II: Anterior arches and cartilage differentiation. Development.
Company of Biologists. https://doi.org/10.1242/dev.123.1.345'
chicago: 'Piotrowski, Tatjana, Thomas Schilling, Michael Brand, Yunjin Jiang, Carl-Philipp
J Heisenberg, Dirk Beuchle, Heiner Grandel, et al. “Jaw and Branchial Arch Mutants
in Zebrafish II: Anterior Arches and Cartilage Differentiation.” Development.
Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.345.'
ieee: 'T. Piotrowski et al., “Jaw and branchial arch mutants in zebrafish
II: Anterior arches and cartilage differentiation,” Development, vol. 123,
no. 1. Company of Biologists, pp. 345–356, 1996.'
ista: 'Piotrowski T, Schilling T, Brand M, Jiang Y, Heisenberg C-PJ, Beuchle D,
Grandel H, Van Eeden F, Furutani Seiki M, Granato M, Haffter P, Hammerschmidt
M, Kane D, Kelsh R, Mullins M, Odenthal J, Warga R, Nüsslein Volhard C. 1996.
Jaw and branchial arch mutants in zebrafish II: Anterior arches and cartilage
differentiation. Development. 123(1), 345–356.'
mla: 'Piotrowski, Tatjana, et al. “Jaw and Branchial Arch Mutants in Zebrafish II:
Anterior Arches and Cartilage Differentiation.” Development, vol. 123,
no. 1, Company of Biologists, 1996, pp. 345–56, doi:10.1242/dev.123.1.345.'
short: T. Piotrowski, T. Schilling, M. Brand, Y. Jiang, C.-P.J. Heisenberg, D. Beuchle,
H. Grandel, F. Van Eeden, M. Furutani Seiki, M. Granato, P. Haffter, M. Hammerschmidt,
D. Kane, R. Kelsh, M. Mullins, J. Odenthal, R. Warga, C. Nüsslein Volhard, Development
123 (1996) 345–356.
date_created: 2018-12-11T12:07:17Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-08T08:13:07Z
day: '01'
doi: 10.1242/dev.123.1.345
extern: '1'
external_id:
pmid:
- '9007254 '
intvolume: ' 123'
issue: '1'
language:
- iso: eng
month: '12'
oa_version: None
page: 345 - 356
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1963'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Jaw and branchial arch mutants in zebrafish II: Anterior arches and cartilage
differentiation'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4191'
abstract:
- lang: eng
text: In a screen for embryonic mutants in the zebrafish a large number of mutants
were isolated with abnormal brain morphology, We describe here 26 mutants in 13
complementation groups that show abnormal development of large regions of the
brain, Early neurogenesis is affected in white tail (wit), During segmentation
stages, homozygous wit embryos display an irregularly formed neural keel, particularly
in the hindbrain, Using a variety of molecular markers, a severe increase in the
number of various early differentiating neurons can be demonstrated, In contrast,
late differentiating neurons, radial glial cells and some nonneural cell types,
such as the neural crest-derived melanoblasts, are much reduced, Somitogenesis
appears delayed, In addition, very reduced numbers of melanophores are present
posterior to the mid-trunk, The wit phenotype is reminiscent of neurogenic mutants
in Drosophila, such as Notch or Delta, In mutant parachute (pac) embryos the general
organization of the hindbrain is disturbed and many rounded cells accumulate loosely
in the hindbrain and midbrain ventricles, Mutants in a group of 6 genes, snakehead(snk),
natter (nat), otter (ott) fullbrain (ful) viper (vip) and white snake (wis) develop
collapsed brain ventricles, before showing signs of general degeneration, atlantis
(atl), big head (bid), wicked brain (win), scabland (sbd) and eisspalte (ele)
mutants have different malformation of the brain folds, Some of them have transient
phenotypes, and mutant individuals may grow up to adults.
acknowledgement: We would like to thank Vladimir Korzh, Stefan Krauss, Monte Westerfield,
Tom Jessell, Mark Fishman, Eric Weinberg, Andreas Püschel, Trevor Jowett and Jóse
Campos-Ortega for providing antibodies and cDNA clones. We thank Suresh Jesuthasan
and Tanya Whitfield for many helpful suggestions on the manuscript. Y.-J. J. wants
to thank Christian Müller and Ralf Rupp for their instructive discussion. Y.-J.
J. is a predoctoral fellow supported by Deutscher Akademischer Austauschdienst (DAAD).
article_processing_charge: No
article_type: original
author:
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Dirk
full_name: Beuchle, Dirk
last_name: Beuchle
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Rachel
full_name: Warga, Rachel
last_name: Warga
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Jiang Y, Brand M, Heisenberg C-PJ, et al. Mutations affecting neurogenesis
and brain morphology in the zebrafish, Danio rerio. Development. 1996;123(1):205-216.
doi:10.1242/dev.123.1.205
apa: Jiang, Y., Brand, M., Heisenberg, C.-P. J., Beuchle, D., Furutani Seiki, M.,
Kelsh, R., … Nüsslein Volhard, C. (1996). Mutations affecting neurogenesis and
brain morphology in the zebrafish, Danio rerio. Development. Company of
Biologists. https://doi.org/10.1242/dev.123.1.205
chicago: Jiang, Yunjin, Michael Brand, Carl-Philipp J Heisenberg, Dirk Beuchle,
Makoto Furutani Seiki, Robert Kelsh, Rachel Warga, et al. “Mutations Affecting
Neurogenesis and Brain Morphology in the Zebrafish, Danio Rerio.” Development.
Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.205.
ieee: Y. Jiang et al., “Mutations affecting neurogenesis and brain morphology
in the zebrafish, Danio rerio,” Development, vol. 123, no. 1. Company of
Biologists, pp. 205–216, 1996.
ista: Jiang Y, Brand M, Heisenberg C-PJ, Beuchle D, Furutani Seiki M, Kelsh R, Warga
R, Granato M, Haffter P, Hammerschmidt M, Kane D, Mullins M, Odenthal J, Van Eeden
F, Nüsslein Volhard C. 1996. Mutations affecting neurogenesis and brain morphology
in the zebrafish, Danio rerio. Development. 123(1), 205–216.
mla: Jiang, Yunjin, et al. “Mutations Affecting Neurogenesis and Brain Morphology
in the Zebrafish, Danio Rerio.” Development, vol. 123, no. 1, Company of
Biologists, 1996, pp. 205–16, doi:10.1242/dev.123.1.205.
short: Y. Jiang, M. Brand, C.-P.J. Heisenberg, D. Beuchle, M. Furutani Seiki, R.
Kelsh, R. Warga, M. Granato, P. Haffter, M. Hammerschmidt, D. Kane, M. Mullins,
J. Odenthal, F. Van Eeden, C. Nüsslein Volhard, Development 123 (1996) 205–216.
date_created: 2018-12-11T12:07:30Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-05T09:13:51Z
day: '01'
doi: 10.1242/dev.123.1.205
extern: '1'
external_id:
pmid:
- '9007241'
intvolume: ' 123'
issue: '1'
language:
- iso: eng
month: '12'
oa_version: None
page: 205 - 216
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1926'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mutations affecting neurogenesis and brain morphology in the zebrafish, Danio
rerio
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4186'
abstract:
- lang: eng
text: 'Neural crest development involves cell-fate specification, proliferation,
patterned cell migration, survival and differentiation, Zebrafish neural crest
derivatives include three distinct chromatophores, which are well-suited to genetic
analysis of their development, As part of a large-scale mutagenesis screen for
embryonic/early larval mutations, we have isolated 285 mutations affecting all
aspects of zebrafish larval pigmentation, By complementation analysis, we define
94 genes, We show here that comparison of their phenotypes permits classification
of these mutations according to the types of defects they cause, and these suggest
which process of neural crest development is probably affected, Mutations in eight
genes affect the number of chromatophores: these include strong candidates for
genes necessary for the processes of pigment cell specification and proliferation,
Mutations in five genes remove part of the wild-type pigment pattern, and suggest
a role in larval pigment pattern formation, Mutations in five genes show ectopic
chromatophores in distinct sites, and may have implications for chromatophore
patterning and proliferation, 76 genes affect pigment or morphology of one or
more chromatophore types: these mutations include strong candidates for genes
important in various aspects of chromatophore differentiation and survival, In
combination with the embryological advantages of zebrafish, these mutations should
permit cellular and molecular dissection of many aspects of neural crest development.'
acknowledgement: We wish to thank Drs Judith Eisen, Steve Johnson, Dave Raible and
Jim Weston for valuable comments. R. N. K. was supported by a NATO Postdoctoral
Fellowship.
article_processing_charge: No
article_type: original
author:
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Shuo
full_name: Lin, Shuo
last_name: Lin
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Rachel
full_name: Warga, Rachel
last_name: Warga
- first_name: Dirk
full_name: Beuchle, Dirk
last_name: Beuchle
- first_name: Lisa
full_name: Vogelsang, Lisa
last_name: Vogelsang
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Kelsh R, Brand M, Jiang Y, et al. Zebrafish pigmentation mutations and the
processes of neural crest development. Development. 1996;123(1):369-389.
doi:10.1242/dev.123.1.369
apa: Kelsh, R., Brand, M., Jiang, Y., Heisenberg, C.-P. J., Lin, S., Haffter, P.,
… Nüsslein Volhard, C. (1996). Zebrafish pigmentation mutations and the processes
of neural crest development. Development. Company of Biologists. https://doi.org/10.1242/dev.123.1.369
chicago: Kelsh, Robert, Michael Brand, Yunjin Jiang, Carl-Philipp J Heisenberg,
Shuo Lin, Pascal Haffter, Jörg Odenthal, et al. “Zebrafish Pigmentation Mutations
and the Processes of Neural Crest Development.” Development. Company of
Biologists, 1996. https://doi.org/10.1242/dev.123.1.369.
ieee: R. Kelsh et al., “Zebrafish pigmentation mutations and the processes
of neural crest development,” Development, vol. 123, no. 1. Company of
Biologists, pp. 369–389, 1996.
ista: Kelsh R, Brand M, Jiang Y, Heisenberg C-PJ, Lin S, Haffter P, Odenthal J,
Mullins M, Van Eeden F, Furutani Seiki M, Granato M, Hammerschmidt M, Kane D,
Warga R, Beuchle D, Vogelsang L, Nüsslein Volhard C. 1996. Zebrafish pigmentation
mutations and the processes of neural crest development. Development. 123(1),
369–389.
mla: Kelsh, Robert, et al. “Zebrafish Pigmentation Mutations and the Processes of
Neural Crest Development.” Development, vol. 123, no. 1, Company of Biologists,
1996, pp. 369–89, doi:10.1242/dev.123.1.369.
short: R. Kelsh, M. Brand, Y. Jiang, C.-P.J. Heisenberg, S. Lin, P. Haffter, J.
Odenthal, M. Mullins, F. Van Eeden, M. Furutani Seiki, M. Granato, M. Hammerschmidt,
D. Kane, R. Warga, D. Beuchle, L. Vogelsang, C. Nüsslein Volhard, Development
123 (1996) 369–389.
date_created: 2018-12-11T12:07:28Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-05T11:16:49Z
day: '01'
doi: 10.1242/dev.123.1.369
extern: '1'
external_id:
pmid:
- '9007256 '
intvolume: ' 123'
issue: '1'
language:
- iso: eng
month: '12'
oa_version: None
page: 369 - 389
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1933'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Zebrafish pigmentation mutations and the processes of neural crest development
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4189'
abstract:
- lang: eng
text: 'This report describes mutants of the zebrafish having phenotypes causing
a general arrest in early morphogenesis. These mutants identify a group of loci
making up about 20% of the loci identified by mutants with visible morphological
phenotypes within the first day of development. There are 12 Class I mutants,
which fall into 5 complementation groups and have cells that lyse before morphological
defects are observed. Mutants at three loci, speed bump, ogre and zombie, display
abnormal nuclei. The 8 Class II mutants, which fall into 6 complementation groups,
arrest development before cell lysis is observed. These mutants seemingly stop
development in the late segmentation stages, and maintain a body shape similar
to a 20 hour embryo. Mutations in speed bump, ogre, zombie, specter, poltergeist
and troll were tested for cell lethality by transplanting mutant cells into wild-type
hosts. With poltergeist, transplanted mutant cells all survive. The remainder
of the mutants tested were autonomously but conditionally lethal: mutant cells,
most of which lyse, sometimes survive to become notochord, muscles, or, in rare
cases, large neurons, all cell types which become postmitotic in the gastrula.
Some of the genes of the early arrest group may be necessary for progression though
the cell cycle; if so, the survival of early differentiating cells may be based
on having their terminal mitosis before the zygotic requirement for these genes.'
acknowledgement: We thank Dr Adam Felsenfeld for his careful comments on earlier drafts
of this manuscript, D. A. K. also thanks the two anonymous referees who patiently
pointed out a number of ‘speed bumps’ in the first submitted draft of this manuscript.
This work was supported in part by a grant from the National Institutes of Health
to D. A. K.
article_processing_charge: No
article_type: original
author:
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Hans
full_name: Maischein, Hans
last_name: Maischein
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Rachel
full_name: Warga, Rachel
last_name: Warga
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Kane D, Maischein H, Brand M, et al. The zebrafish early arrest mutants. Development.
1996;123(1):57-66. doi:10.1242/dev.123.1.57
apa: Kane, D., Maischein, H., Brand, M., Van Eeden, F., Furutani Seiki, M., Granato,
M., … Nüsslein Volhard, C. (1996). The zebrafish early arrest mutants. Development.
Company of Biologists. https://doi.org/10.1242/dev.123.1.57
chicago: Kane, Donald, Hans Maischein, Michael Brand, Fredericus Van Eeden, Makoto
Furutani Seiki, Michael Granato, Pascal Haffter, et al. “The Zebrafish Early Arrest
Mutants.” Development. Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.57 .
ieee: D. Kane et al., “The zebrafish early arrest mutants,” Development,
vol. 123, no. 1. Company of Biologists, pp. 57–66, 1996.
ista: Kane D, Maischein H, Brand M, Van Eeden F, Furutani Seiki M, Granato M, Haffter
P, Hammerschmidt M, Heisenberg C-PJ, Jiang Y, Kelsh R, Mullins M, Odenthal J,
Warga R, Nüsslein Volhard C. 1996. The zebrafish early arrest mutants. Development.
123(1), 57–66.
mla: Kane, Donald, et al. “The Zebrafish Early Arrest Mutants.” Development,
vol. 123, no. 1, Company of Biologists, 1996, pp. 57–66, doi:10.1242/dev.123.1.57 .
short: D. Kane, H. Maischein, M. Brand, F. Van Eeden, M. Furutani Seiki, M. Granato,
P. Haffter, M. Hammerschmidt, C.-P.J. Heisenberg, Y. Jiang, R. Kelsh, M. Mullins,
J. Odenthal, R. Warga, C. Nüsslein Volhard, Development 123 (1996) 57–66.
date_created: 2018-12-11T12:07:29Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-05T09:43:44Z
day: '01'
doi: '10.1242/dev.123.1.57 '
extern: '1'
external_id:
pmid:
- '9007229 '
intvolume: ' 123'
issue: '1'
language:
- iso: eng
month: '12'
oa_version: None
page: 57 - 66
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1931'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The zebrafish early arrest mutants
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4188'
abstract:
- lang: eng
text: 'Epiboly, the enveloping of the yolk cell by the blastoderm, is the first
zebrafish morphogenetic movement, We isolated four mutations that affect epiboly:
half baked, avalanche, lawine and weg, Homozygous mutant embryos arrest the vegetal
progress of the deep cells of the blastoderm; only the yolk syncytial layer of
the yolk cell and the enveloping layer of the blastoderm reach the vegetal pole
of the embryo, The mutations half baked, avalanche and lawine produce a novel
dominant effect, termed a zygotic-maternal dominant effect: heterozygous embryos
produced from heterozygous females slow down epiboly and accumulate detached cells
over the neural tube; a small fraction of these mutant individuals are viable,
Heterozygous embryos produced from heterozygous males crossed to homozygous wild-type
females complete epiboly normally and are completely viable. Additionally, embryos
heterozygous for half baked have an enlarged hatching gland, a partial dominant
phenotype, The phenotypes of these mutants demonstrate that, for the spreading
of cells during epiboly, the movement of the deep cells of the blastoderm require
the function of genes that are not necessary for the movement of the enveloping
layer or the yolk cell, Furthermore, the dominant zygotic-maternal effect phenotypes
illustrate the maternal and zygotic interplay of genes that orchestrate the early
cell movements of the zebrafish.'
acknowledgement: We thank Drs John Postlethwait and Sigfreid Roth for their helpful
comments on earlier drafts of this paper. This work was supported in part by a grant
from the National Institutes of Health to D. A. K.
article_processing_charge: No
article_type: original
author:
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Hans
full_name: Maischein, Hans
last_name: Maischein
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Rachel
full_name: Warga, Rachel
last_name: Warga
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Kane D, Hammerschmidt M, Mullins M, et al. The zebrafish epiboly mutants. Development.
1996;123(1):47-55. doi:10.1242/dev.123.1.47
apa: Kane, D., Hammerschmidt, M., Mullins, M., Maischein, H., Brand, M., Van Eeden,
F., … Nüsslein Volhard, C. (1996). The zebrafish epiboly mutants. Development.
Company of Biologists. https://doi.org/10.1242/dev.123.1.47
chicago: Kane, Donald, Matthias Hammerschmidt, Mary Mullins, Hans Maischein, Michael
Brand, Fredericus Van Eeden, Makoto Furutani Seiki, et al. “The Zebrafish Epiboly
Mutants.” Development. Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.47 .
ieee: D. Kane et al., “The zebrafish epiboly mutants,” Development,
vol. 123, no. 1. Company of Biologists, pp. 47–55, 1996.
ista: Kane D, Hammerschmidt M, Mullins M, Maischein H, Brand M, Van Eeden F, Furutani
Seiki M, Granato M, Haffter P, Heisenberg C-PJ, Jiang Y, Kelsh R, Odenthal J,
Warga R, Nüsslein Volhard C. 1996. The zebrafish epiboly mutants. Development.
123(1), 47–55.
mla: Kane, Donald, et al. “The Zebrafish Epiboly Mutants.” Development, vol.
123, no. 1, Company of Biologists, 1996, pp. 47–55, doi:10.1242/dev.123.1.47 .
short: D. Kane, M. Hammerschmidt, M. Mullins, H. Maischein, M. Brand, F. Van Eeden,
M. Furutani Seiki, M. Granato, P. Haffter, C.-P.J. Heisenberg, Y. Jiang, R. Kelsh,
J. Odenthal, R. Warga, C. Nüsslein Volhard, Development 123 (1996) 47–55.
date_created: 2018-12-11T12:07:29Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-05T09:22:40Z
day: '01'
doi: '10.1242/dev.123.1.47 '
extern: '1'
external_id:
pmid:
- '9007228 '
intvolume: ' 123'
issue: '1'
language:
- iso: eng
month: '12'
oa_version: None
page: 47 - 55
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1930'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The zebrafish epiboly mutants
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4203'
abstract:
- lang: eng
text: 'We identified four zebrafish mutants with defects in forebrain induction
and patterning during embryogenesis. The four mutants define three genes: masterblind
(mbl), silverblick (slb), and knollnase (kas), In mbl embryos, the anterior forebrain
acquires posterior forebrain characteristics: anterior structures such as the
eyes, olfactory placodes and the telencephalon are missing, whereas the epiphysis
located in the posterior forebrain is expanded, In slb embryos, the extension
of the embryonic axis is initially delayed and eventually followed by a partial
fusion of the eyes, Finally, in kas embryos, separation of the telencephalic primordia
is incomplete and dorsal midline cells fail to form a differentiated roof plate,
Analysis of the mutant phenotypes indicates that we have identified genes essential
for the specification of the anterior forebrain (mbl), positioning of the eyes
(slb) and differentiation of the roof plate (kas). In an appendix to this study
we list mutants showing alterations in the size of the eyes and abnormal differentiation
of the lenses.'
acknowledgement: We thank E. Weinberg for the kind gift of myoD, zotx-2 and zash1b
cDNA, I. Mikkola and S. Krauss for providing pax2/6 antibodies and shh cDNA, and
V. Korzh for providing the pan-islet antibody. We are grateful to S. Wilson for
help with the initial characterization of the mbl phenotype and many valuable comments
on the manuscript. We would also like to thank Robert Geisler, Suresh Jesuthasan,
Rolf Karlstrom, Stefan Schulte-Merker and Siegfried Roth for critical reading of
the manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Rachel
full_name: Warga, Rachel
last_name: Warga
- first_name: Dirk
full_name: Beuchle, Dirk
last_name: Beuchle
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Heisenberg C-PJ, Brand M, Jiang Y, et al. Genes involved in forebrain development
in the zebrafish, Danio rerio. Development. 1996;123:191-203. doi:10.1242/dev.123.1.191
apa: Heisenberg, C.-P. J., Brand, M., Jiang, Y., Warga, R., Beuchle, D., Van Eeden,
F., … Nüsslein Volhard, C. (1996). Genes involved in forebrain development in
the zebrafish, Danio rerio. Development. Company of Biologists. https://doi.org/10.1242/dev.123.1.191
chicago: Heisenberg, Carl-Philipp J, Michael Brand, Yunjin Jiang, Rachel Warga,
Dirk Beuchle, Fredericus Van Eeden, Makoto Furutani Seiki, et al. “Genes Involved
in Forebrain Development in the Zebrafish, Danio Rerio.” Development. Company
of Biologists, 1996. https://doi.org/10.1242/dev.123.1.191
.
ieee: C.-P. J. Heisenberg et al., “Genes involved in forebrain development
in the zebrafish, Danio rerio,” Development, vol. 123. Company of Biologists,
pp. 191–203, 1996.
ista: Heisenberg C-PJ, Brand M, Jiang Y, Warga R, Beuchle D, Van Eeden F, Furutani
Seiki M, Granato M, Haffter P, Hammerschmidt M, Kane D, Kelsh R, Mullins M, Odenthal
J, Nüsslein Volhard C. 1996. Genes involved in forebrain development in the zebrafish,
Danio rerio. Development. 123, 191–203.
mla: Heisenberg, Carl-Philipp J., et al. “Genes Involved in Forebrain Development
in the Zebrafish, Danio Rerio.” Development, vol. 123, Company of Biologists,
1996, pp. 191–203, doi:10.1242/dev.123.1.191
.
short: C.-P.J. Heisenberg, M. Brand, Y. Jiang, R. Warga, D. Beuchle, F. Van Eeden,
M. Furutani Seiki, M. Granato, P. Haffter, M. Hammerschmidt, D. Kane, R. Kelsh,
M. Mullins, J. Odenthal, C. Nüsslein Volhard, Development 123 (1996) 191–203.
date_created: 2018-12-11T12:07:34Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-05T08:06:15Z
day: '01'
doi: '10.1242/dev.123.1.191 '
extern: '1'
external_id:
pmid:
- '9007240 '
intvolume: ' 123'
language:
- iso: eng
month: '12'
oa_version: None
page: 191 - 203
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1913'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Genes involved in forebrain development in the zebrafish, Danio rerio
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4216'
abstract:
- lang: eng
text: Tissues of the dorsal midline of vertebrate embryos, such as notochord and
floor plate, have been implicated in inductive interactions that pattern the neural
tube and somites. In our screen for embryonic visible mutations in the zebrafish
we found 113 mutations in more than 27 genes with altered body shape, often with
additional defects in CNS development. We concentrated on a subgroup of mutations
in ten genes (the midline-group) that cause defective development of the floor
plate. By using floor plate markers, such as the signaling molecule sonic hedgehog,
we show that the schmalspur (sur) gene is needed for early floor plate development,
similar to one-eyed-pinhead (oep) and the previously described cyclops (eye) gene.
In contrast to oep and cyc, sur embryos show deletions of ventral CNS tissue restricted
to the mid- and hindbrain, whereas the forebrain appears largely unaffected. In
the underlying mesendodermal tissue of the head, sur is needed only for development
of the posterior prechordal plate, whereas oep and eye are required for both anterior
and posterior prechordal plate development. Our analysis of sur mutants suggests
that defects within the posterior prechordal plate may cause aberrant development
of ventral CNS structures in the mid- and hindbrain. Later development of the
floor plate is affected in mutant chameleon, you-too, sonic-you, iguana, detour,
schmalkars and monorail embryos; these mutants often show additional defects in
tissues that are known to depend on signals from notochord and floor plate, For
example, sur, con, and yot mutants show reduction of motor neurons; median deletions
of brain tissue are seen in sur, con and yot embryos; and eye, con, yet, igu and
dtr mutants often show no or abnormal formation of the optic chiasm. We also find
fusions of the ventral neurocranium for all midline mutants tested, which may
reveal a hitherto unrecognized function of the midline in influencing differentiation
of neural crest cells at their destination. As a working hypothesis, we propose
that midline-group genes may act to maintain proper structure and inductive function
of zebrafish midline tissues.
acknowledgement: "We would like to thank our colleagues in the zebrafish community
for generously sharing antibodies and probes, in particular PhilIngham, Stefan Krauss
and Vladimir Korzh, as well as Tom Jessel, Trevor Jowett, Anders Molven, Eric Weinberg
and Monte Westerfield. M. B. thanks Steve Wilson for comments on the manuscript,
his colleagues at the institute for numerous discussions, Inge Zimmermann for patient
sectioning, and Silke Hein for help during the final\r\nstages of this work. M.
B. was supported by a Helmholtz stipend of the BMFT."
article_processing_charge: No
article_type: original
author:
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Rachel
full_name: Warga, Rachel
last_name: Warga
- first_name: Francisco
full_name: Pelegri, Francisco
last_name: Pelegri
- first_name: Rolf
full_name: Karlstrom, Rolf
last_name: Karlstrom
- first_name: Dirk
full_name: Beuchle, Dirk
last_name: Beuchle
- first_name: Alexander
full_name: Picker, Alexander
last_name: Picker
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Brand M, Heisenberg C-PJ, Warga R, et al. Mutations affecting development of
the midline and general body shape during zebrafish embryogenesis. Development.
1996;123(1):129-142. doi:10.1242/dev.123.1.129
apa: Brand, M., Heisenberg, C.-P. J., Warga, R., Pelegri, F., Karlstrom, R., Beuchle,
D., … Nüsslein Volhard, C. (1996). Mutations affecting development of the midline
and general body shape during zebrafish embryogenesis. Development. Company
of Biologists. https://doi.org/10.1242/dev.123.1.129
chicago: Brand, Michael, Carl-Philipp J Heisenberg, Rachel Warga, Francisco Pelegri,
Rolf Karlstrom, Dirk Beuchle, Alexander Picker, et al. “Mutations Affecting Development
of the Midline and General Body Shape during Zebrafish Embryogenesis.” Development.
Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.129
.
ieee: M. Brand et al., “Mutations affecting development of the midline and
general body shape during zebrafish embryogenesis,” Development, vol. 123,
no. 1. Company of Biologists, pp. 129–142, 1996.
ista: Brand M, Heisenberg C-PJ, Warga R, Pelegri F, Karlstrom R, Beuchle D, Picker
A, Jiang Y, Furutani Seiki M, Van Eeden F, Granato M, Haffter P, Hammerschmidt
M, Kane D, Kelsh R, Mullins M, Odenthal J, Nüsslein Volhard C. 1996. Mutations
affecting development of the midline and general body shape during zebrafish embryogenesis.
Development. 123(1), 129–142.
mla: Brand, Michael, et al. “Mutations Affecting Development of the Midline and
General Body Shape during Zebrafish Embryogenesis.” Development, vol. 123,
no. 1, Company of Biologists, 1996, pp. 129–42, doi:10.1242/dev.123.1.129 .
short: M. Brand, C.-P.J. Heisenberg, R. Warga, F. Pelegri, R. Karlstrom, D. Beuchle,
A. Picker, Y. Jiang, M. Furutani Seiki, F. Van Eeden, M. Granato, P. Haffter,
M. Hammerschmidt, D. Kane, R. Kelsh, M. Mullins, J. Odenthal, C. Nüsslein Volhard,
Development 123 (1996) 129–142.
date_created: 2018-12-11T12:07:38Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-04T12:55:13Z
day: '01'
doi: '10.1242/dev.123.1.129 '
extern: '1'
external_id:
pmid:
- '9007235 '
intvolume: ' 123'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://journals.biologists.com/dev/article/123/1/129/39318/Mutations-affecting-development-of-the-midline-and
month: '12'
oa: 1
oa_version: Published Version
page: 129 - 142
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1900'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mutations affecting development of the midline and general body shape during
zebrafish embryogenesis
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4219'
abstract:
- lang: eng
text: 'Mutations in two genes affect the formation of the boundary between midbrain
and hindbrain (MHB): no isthmus (noi) and acerebellar (ace), noi mutant embryos
lack the MHB constriction, the cerebellum and optic tectum, as well as the pronephric
duct. Analysis of noi mutant embryos with neuron-specific antibodies shows that
the MHB region and the dorsal and ventral midbrain are absent or abnormal, but
that the rostral hindbrain is unaffected with the exception of the cerebellum,
Using markers that are expressed during its formation (eng, wnt1 and pax-b), we
find that the MHB region is already misspecified in noi mutant embryos during
late gastrulation. The tectum is initially present and later degenerates, The
defect in ace mutant embryos is more restricted: MHB and cerebellum are absent,
but a tectum is formed, Molecular organisation of the tectum and tegmentum is
disturbed, however, since eng, wntl and pax-b marker gene expression is not maintained,
We propose that noi and ace are required for development of the MHB region and
of the adjacent mid- and hindbrain, which are thought to be patterned by the MHB
region, Presence of pax-b RNA, and absence of pax-b protein, together with the
observation of genetic linkage and the occurrence of a point mutation, show that
noi mutations are located in the pax-b gene, pax-b is a vertebrate orthologue
of the Drosophila gene paired, which is involved in a pathway of cellular interactions
at the posterior compartment boundary in Drosophila, Our results confirm and extend
a previous report, and show that at least one member of this conserved signalling
pathway is required for formation of the boundary between midbrain and hindbrain
in the zebrafish.'
acknowledgement: "We would like to thank our colleagues in the zebrafish community
for generously sharing antibodies and probes, in particular Terje Johannsen, Vladimir
Korzh, Stefan Krauss and Ingvild Mikkola, as well as Christine Dreyer, Nigel Holder,
Tom Jessel, Trevor Jowett, Anders Molven, Eric Weinberg and Monte Westerfield. M.B
would like to thank his colleagues for numerous discussions, and Francisco Pelegri,
Suresh Jesuthasan and Luis Puelles for comments on the\r\nmanuscipt. Thanks also
to Peter Andermann and Eric Weinberg, who helped in the analysis of Zash expression,
and especially to Corinne Houart, for her lovely in situ protocol and many discussions.
Silke Hein helped greatly in final stages of this work. M.B. was supported by a
Helmholtz stipend of the BMFT."
article_processing_charge: No
article_type: original
author:
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Dirk
full_name: Beuchle, Dirk
last_name: Beuchle
- first_name: Klaus
full_name: Lun, Klaus
last_name: Lun
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Brand M, Heisenberg C-PJ, Jiang Y, et al. Mutations in zebrafish genes affecting
the formation of the boundary between midbrain and hindbrain. Development.
1996;123(1):179-190. doi:10.1242/dev.123.1.179
apa: Brand, M., Heisenberg, C.-P. J., Jiang, Y., Beuchle, D., Lun, K., Furutani
Seiki, M., … Nüsslein Volhard, C. (1996). Mutations in zebrafish genes affecting
the formation of the boundary between midbrain and hindbrain. Development.
Company of Biologists. https://doi.org/10.1242/dev.123.1.179
chicago: Brand, Michael, Carl-Philipp J Heisenberg, Yunjin Jiang, Dirk Beuchle,
Klaus Lun, Makoto Furutani Seiki, Michael Granato, et al. “Mutations in Zebrafish
Genes Affecting the Formation of the Boundary between Midbrain and Hindbrain.”
Development. Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.179 .
ieee: M. Brand et al., “Mutations in zebrafish genes affecting the formation
of the boundary between midbrain and hindbrain,” Development, vol. 123,
no. 1. Company of Biologists, pp. 179–190, 1996.
ista: Brand M, Heisenberg C-PJ, Jiang Y, Beuchle D, Lun K, Furutani Seiki M, Granato
M, Haffter P, Hammerschmidt M, Kane D, Kelsh R, Mullins M, Odenthal J, Van Eeden
F, Nüsslein Volhard C. 1996. Mutations in zebrafish genes affecting the formation
of the boundary between midbrain and hindbrain. Development. 123(1), 179–190.
mla: Brand, Michael, et al. “Mutations in Zebrafish Genes Affecting the Formation
of the Boundary between Midbrain and Hindbrain.” Development, vol. 123,
no. 1, Company of Biologists, 1996, pp. 179–90, doi:10.1242/dev.123.1.179 .
short: M. Brand, C.-P.J. Heisenberg, Y. Jiang, D. Beuchle, K. Lun, M. Furutani Seiki,
M. Granato, P. Haffter, M. Hammerschmidt, D. Kane, R. Kelsh, M. Mullins, J. Odenthal,
F. Van Eeden, C. Nüsslein Volhard, Development 123 (1996) 179–190.
date_created: 2018-12-11T12:07:40Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-04T11:45:04Z
day: '01'
doi: '10.1242/dev.123.1.179 '
extern: '1'
external_id:
pmid:
- '9007239 '
intvolume: ' 123'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://journals.biologists.com/dev/article/123/1/179/39324/Mutations-in-zebrafish-genes-affecting-the
month: '12'
oa: 1
oa_version: Published Version
page: 179 - 190
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1899'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mutations in zebrafish genes affecting the formation of the boundary between
midbrain and hindbrain
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4222'
abstract:
- lang: eng
text: Somitogenesis is the basis of segmentation of the mesoderm in the trunk and
tail of vertebrate embryos, Two groups of mutants with defects in this patterning
process have been isolated in our screen for zygotic mutations affecting the embryonic
development of the zebrafish (Danio rerio), In mutants of the first group, boundaries
between individual somites are invisible early on, although the paraxial mesoderm
is present, Later, irregular boundaries between somites are present, Mutations
infused somites (fss) and beamter (bea) affect all somites, whereas mutations
in deadly seven (des), after eight (aei) and white tail (wit) only affect the
more posterior somites, Mutants of all genes but wit are homozygous viable and
fertile, Skeletal stainings and the expression pattern of myoD and snail1 suggest
that anteroposterior patterning within individual somites is abnormal, In the
second group of mutants, formation of the horizontal myoseptum, which separates
the dorsal and ventral part of the myotome, is reduced, Six genes have been defined
in this group (you-type genes), yea-too mutants show the most severe phenotype;
in these the adaxial cells, muscle pioneers and the primary motoneurons are affected,
in addition to the horizontal myoseptum. The horizontal myoseptum is also missing
in mutants that lack a notochord. The similarity of the somite phenotype in mutants
lacking the notochord and in the you-type mutants suggests that the genes mutated
in these two groups are involved in a signaling pathway from the notochord, important
for patterning of the somites.
acknowledgement: We would like to thank P. Ingham and T. Whitfield for valuable comments
on the manuscript and cDNA probes, S. Schulte-Merker for the Ntl antibody and J.
Eisen and R. BreMiller for the znp-1 antibody.
article_processing_charge: No
article_type: original
author:
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Ursula
full_name: Schach, Ursula
last_name: Schach
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Rachel
full_name: Warga, Rachel
last_name: Warga
- first_name: Miguel
full_name: Allende, Miguel
last_name: Allende
- first_name: Eric
full_name: Weinberg, Eric
last_name: Weinberg
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Van Eeden F, Granato M, Schach U, et al. Mutations affecting somite formation
and patterning in the zebrafish, Danio rerio. Development. 1996;123(1):153-164.
doi:10.1242/dev.123.1.153
apa: Van Eeden, F., Granato, M., Schach, U., Brand, M., Furutani Seiki, M., Haffter,
P., … Nüsslein Volhard, C. (1996). Mutations affecting somite formation and patterning
in the zebrafish, Danio rerio. Development. Company of Biologists. https://doi.org/10.1242/dev.123.1.153
chicago: Van Eeden, Fredericus, Michael Granato, Ursula Schach, Michael Brand, Makoto
Furutani Seiki, Pascal Haffter, Matthias Hammerschmidt, et al. “Mutations Affecting
Somite Formation and Patterning in the Zebrafish, Danio Rerio.” Development.
Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.153.
ieee: F. Van Eeden et al., “Mutations affecting somite formation and patterning
in the zebrafish, Danio rerio,” Development, vol. 123, no. 1. Company of
Biologists, pp. 153–164, 1996.
ista: Van Eeden F, Granato M, Schach U, Brand M, Furutani Seiki M, Haffter P, Hammerschmidt
M, Heisenberg C-PJ, Jiang Y, Kane D, Kelsh R, Mullins M, Odenthal J, Warga R,
Allende M, Weinberg E, Nüsslein Volhard C. 1996. Mutations affecting somite formation
and patterning in the zebrafish, Danio rerio. Development. 123(1), 153–164.
mla: Van Eeden, Fredericus, et al. “Mutations Affecting Somite Formation and Patterning
in the Zebrafish, Danio Rerio.” Development, vol. 123, no. 1, Company of
Biologists, 1996, pp. 153–64, doi:10.1242/dev.123.1.153.
short: F. Van Eeden, M. Granato, U. Schach, M. Brand, M. Furutani Seiki, P. Haffter,
M. Hammerschmidt, C.-P.J. Heisenberg, Y. Jiang, D. Kane, R. Kelsh, M. Mullins,
J. Odenthal, R. Warga, M. Allende, E. Weinberg, C. Nüsslein Volhard, Development
123 (1996) 153–164.
date_created: 2018-12-11T12:07:41Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-04T09:29:56Z
day: '01'
doi: 10.1242/dev.123.1.153
extern: '1'
external_id:
pmid:
- '9007237 '
intvolume: ' 123'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://journals.biologists.com/dev/article/123/1/153/39329/Mutations-affecting-somite-formation-and
month: '12'
oa: 1
oa_version: Published Version
page: 153 - 164
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1895'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mutations affecting somite formation and patterning in the zebrafish, Danio
rerio
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4220'
abstract:
- lang: eng
text: In the zebrafish, Danio rerio, a caudal and pectoral fin fold develop during
embryogenesis. At larval stages the caudal fin fold is replaced by four different
fins, the unpaired anal, dorsal and tail fins. In addition the paired pelvic fins
are formed, We have identified a total of 118 mutations affecting larval fin formation,
Mutations in 11 genes lead to abnormal morphology or degeneration of both caudal
and pectoral fin folds, Most mutants survive to adulthood and form a surprisingly
normal complement of adult fins, Mutations in nine genes result in an increased
or reduced size of the pectoral fins, Interestingly, in mutants of one of these
genes, dackel (dak), pectoral fin buds form initially, but later the fin epithelium
fails to expand, Expression of sonic hedgehog mRNA in the posterior mesenchyme
of the pectoral fin bud is initiated in dak embryos, but not maintained, Mutations
in five other genes affect adult fin but not larval fin development, Two mutants,
longfin (lof) and another longfin (alf) have generally longer fins. Stein und
bein (sub) has reduced dorsal and pelvic fins, whereas finless (fls) and wanda
(wan) mutants affect all adult fins, Finally, mutations in four genes causing
defects in embryonic skin formation will be briefly reported.
article_processing_charge: No
article_type: original
author:
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Ursula
full_name: Schach, Ursula
last_name: Schach
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Rachel
full_name: Warga, Rachel
last_name: Warga
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Van Eeden F, Granato M, Schach U, et al. Genetic analysis of fin formation
in the zebrafish, Danio rerio. Development. 1996;123(1):255-262. doi:10.1242/dev.123.1.255
apa: Van Eeden, F., Granato, M., Schach, U., Brand, M., Furutani Seiki, M., Haffter,
P., … Nüsslein Volhard, C. (1996). Genetic analysis of fin formation in the zebrafish,
Danio rerio. Development. Company of Biologists. https://doi.org/10.1242/dev.123.1.255
chicago: Van Eeden, Fredericus, Michael Granato, Ursula Schach, Michael Brand, Makoto
Furutani Seiki, Pascal Haffter, Matthias Hammerschmidt, et al. “Genetic Analysis
of Fin Formation in the Zebrafish, Danio Rerio.” Development. Company of
Biologists, 1996. https://doi.org/10.1242/dev.123.1.255
.
ieee: F. Van Eeden et al., “Genetic analysis of fin formation in the zebrafish,
Danio rerio,” Development, vol. 123, no. 1. Company of Biologists, pp.
255–262, 1996.
ista: Van Eeden F, Granato M, Schach U, Brand M, Furutani Seiki M, Haffter P, Hammerschmidt
M, Heisenberg C-PJ, Jiang Y, Kane D, Kelsh R, Mullins M, Odenthal J, Warga R,
Nüsslein Volhard C. 1996. Genetic analysis of fin formation in the zebrafish,
Danio rerio. Development. 123(1), 255–262.
mla: Van Eeden, Fredericus, et al. “Genetic Analysis of Fin Formation in the Zebrafish,
Danio Rerio.” Development, vol. 123, no. 1, Company of Biologists, 1996,
pp. 255–62, doi:10.1242/dev.123.1.255
.
short: F. Van Eeden, M. Granato, U. Schach, M. Brand, M. Furutani Seiki, P. Haffter,
M. Hammerschmidt, C.-P.J. Heisenberg, Y. Jiang, D. Kane, R. Kelsh, M. Mullins,
J. Odenthal, R. Warga, C. Nüsslein Volhard, Development 123 (1996) 255–262.
date_created: 2018-12-11T12:07:40Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-04T10:01:17Z
day: '01'
doi: '10.1242/dev.123.1.255 '
extern: '1'
external_id:
pmid:
- '9007245 '
intvolume: ' 123'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://journals.biologists.com/dev/article/123/1/255/39327/Genetic-analysis-of-fin-formation-in-the-zebrafish
month: '12'
oa: 1
oa_version: Published Version
page: 255 - 262
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1896'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Genetic analysis of fin formation in the zebrafish, Danio rerio
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4294'
abstract:
- lang: eng
text: 'Any sample of genes traces back to a single common ancestor. Each gene also
has other properties: its sequence, its geographic location and the phenotype
and fitness of the organism that carries it. With sexual reproduction, different
genes have different genealogies, which gives us much more information, but also
greatly complicates population genetic analysis. We review the close relation
between the distribution of genealogies and the classic theory of identity by
descent in spatially structured populations, and develop a simple diffusion approximation
to the distribution of coalescence times in a homogeneous two-dimensional habitat.
This shows that when neighbourhood size is large (as in most populations) only
a small fraction of pairs of genes are closely related, and only this fraction
gives information about current rates of gene flow. The increase of spatial dispersion
with lineage age is thus a poor estimator of gene flow. The bulk of the genealogy
depends on the long-term history of the population; we discuss ways of inferring
this history from the concordance between genealogies across loci.'
article_processing_charge: No
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Ian
full_name: Wilson, Ian
last_name: Wilson
citation:
ama: 'Barton NH, Wilson I. Genealogies and geography. In: New Uses for New Phylogenies.
Oxford University Press; 1996:23-56. doi:10.1098/rstb.1995.0090'
apa: Barton, N. H., & Wilson, I. (1996). Genealogies and geography. In New
uses for new phylogenies (pp. 23–56). Oxford University Press. https://doi.org/10.1098/rstb.1995.0090
chicago: Barton, Nicholas H, and Ian Wilson. “Genealogies and Geography.” In New
Uses for New Phylogenies, 23–56. Oxford University Press, 1996. https://doi.org/10.1098/rstb.1995.0090.
ieee: N. H. Barton and I. Wilson, “Genealogies and geography,” in New uses for
new phylogenies, Oxford University Press, 1996, pp. 23–56.
ista: 'Barton NH, Wilson I. 1996.Genealogies and geography. In: New uses for new
phylogenies. , 23–56.'
mla: Barton, Nicholas H., and Ian Wilson. “Genealogies and Geography.” New Uses
for New Phylogenies, Oxford University Press, 1996, pp. 23–56, doi:10.1098/rstb.1995.0090.
short: N.H. Barton, I. Wilson, in:, New Uses for New Phylogenies, Oxford University
Press, 1996, pp. 23–56.
date_created: 2018-12-11T12:08:05Z
date_published: 1996-01-01T00:00:00Z
date_updated: 2022-08-04T08:59:18Z
day: '01'
doi: 10.1098/rstb.1995.0090
extern: '1'
external_id:
pmid:
- '8748019'
language:
- iso: eng
month: '01'
oa_version: None
page: 23 - 56
pmid: 1
publication: New uses for new phylogenies
publication_identifier:
isbn:
- 978-0198549840
publication_status: published
publisher: Oxford University Press
publist_id: '1783'
quality_controlled: '1'
status: public
title: Genealogies and geography
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '1996'
...
---
_id: '4295'
abstract:
- lang: eng
text: Genetic studies are beginning to provide insights into the evolutionary processes
that reduce the fitness of hybrids between recently diverged species. However,
the deleterious gene interactions responsible for this fitness reduction are still
poorly understood.
acknowledgement: Thanks to Brian Charlesworth, Jerry Coyne, Allen Orr and Michael
Turelli for their comments on this note, and to the BBSRC and NERC for financial
support.
article_processing_charge: No
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: 'Barton NH. Speciation: more than the sum of its parts. In: Current Biology.
Vol 6. Cell Press; 1996:1244-1246. doi:10.1016/S0960-9822(02)70707-0'
apa: 'Barton, N. H. (1996). Speciation: more than the sum of its parts. In Current
Biology (Vol. 6, pp. 1244–1246). Cell Press. https://doi.org/10.1016/S0960-9822(02)70707-0'
chicago: 'Barton, Nicholas H. “Speciation: More than the Sum of Its Parts.” In Current
Biology, 6:1244–46. Cell Press, 1996. https://doi.org/10.1016/S0960-9822(02)70707-0.'
ieee: 'N. H. Barton, “Speciation: more than the sum of its parts,” in Current
Biology, vol. 6, Cell Press, 1996, pp. 1244–1246.'
ista: 'Barton NH. 1996.Speciation: more than the sum of its parts. In: Current Biology.
vol. 6, 1244–1246.'
mla: 'Barton, Nicholas H. “Speciation: More than the Sum of Its Parts.” Current
Biology, vol. 6, Cell Press, 1996, pp. 1244–46, doi:10.1016/S0960-9822(02)70707-0.'
short: N.H. Barton, in:, Current Biology, Cell Press, 1996, pp. 1244–1246.
date_created: 2018-12-11T12:08:06Z
date_published: 1996-10-01T00:00:00Z
date_updated: 2022-07-07T09:28:28Z
day: '01'
doi: 10.1016/S0960-9822(02)70707-0
extern: '1'
external_id:
pmid:
- '8939554'
intvolume: ' 6'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/S0960982202707070?via%3Dihub
month: '10'
oa: 1
oa_version: Published Version
page: 1244 - 1246
pmid: 1
publication: Current Biology
publication_identifier:
issn:
- 0960-9822
publication_status: published
publisher: Cell Press
publist_id: '1781'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Speciation: more than the sum of its parts'
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 6
year: '1996'
...
---
_id: '4419'
abstract:
- lang: eng
text: A {\em hybrid automaton\/} consists of a finite automaton interacting with
a dynamical system. Hybrid automata are used to model embedded controllers and
other systems that consist of interacting discrete and continuous components.
A hybrid automaton is {\em rectangular\/} if each of its continuous variables~x
satisfies a nondeterministic differential equation of the form a≤dxdt≤b, where
a and~b are rational constants. Rectangular hybrid automata are particularly useful
for the analysis of communication protocols in which local clocks have bounded
drift, and for the conservative approximation of systems with more complex continuous
behavior. We examine several verification problems on the class of rectangular
hybrid automata, including reachability, temporal logic model checking, and controller
synthesis. Both dense-time and discrete-time models are considered. We identify
subclasses of rectangular hybrid automata for which these problems are decidable
and give complexity analyses. An investigation of the structural properties of
rectangular hybrid automata is undertaken. One method for proving the decidability
of verification problems on infinite-state systems is to find finite quotient
systems on which analysis can proceed. Three state-space equivalence relations
with strong connections to temporal logic are bisimilarity, similarity, and language
equivalence. We characterize the quotient spaces of rectangular hybrid automata
with respect to these equivalence relations.
article_processing_charge: No
author:
- first_name: Peter
full_name: Kopke, Peter
last_name: Kopke
citation:
ama: Kopke P. The Theory of Rectangular Hybrid Automata. 1996.
apa: Kopke, P. (1996). The Theory of Rectangular Hybrid Automata. Cornell
University.
chicago: Kopke, Peter. “The Theory of Rectangular Hybrid Automata.” Cornell University,
1996.
ieee: P. Kopke, “The Theory of Rectangular Hybrid Automata,” Cornell University,
1996.
ista: Kopke P. 1996. The Theory of Rectangular Hybrid Automata. Cornell University.
mla: Kopke, Peter. The Theory of Rectangular Hybrid Automata. Cornell University,
1996.
short: P. Kopke, The Theory of Rectangular Hybrid Automata, Cornell University,
1996.
date_created: 2018-12-11T12:08:45Z
date_published: 1996-01-01T00:00:00Z
date_updated: 2022-07-06T15:11:24Z
day: '01'
extern: '1'
language:
- iso: eng
month: '01'
oa_version: None
publication_status: published
publisher: Cornell University
publist_id: '312'
status: public
supervisor:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000-0002-2985-7724
title: The Theory of Rectangular Hybrid Automata
type: dissertation
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '1996'
...
---
_id: '4426'
abstract:
- lang: eng
text: We use linear hybrid automata to define linear approximations of the phase
portraits of nonlinear hybrid systems. The approximating automata can be analyzed
automatically using the symbolic model checker HyTech. We demonstrate the technique
through the study of predator-prey systems, where we compute population bounds
for both species. We also identify a class of nonlinear hybrid automata for which
linear phase-portrait approximations can be generated automatically.
acknowledgement: This research was supported in part by the ONR YIP award N00014-95-1-0520,
by the NSF CAREER award CCR-9501708, by the NSF grants CCR-9200794 and CCR-9504469,
by the AFOSR contract F49620-93-1-0056, and by the ARPA grant NAG2-892.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Howard
full_name: Wong Toi, Howard
last_name: Wong Toi
citation:
ama: 'Henzinger TA, Wong Toi H. Linear phase-portrait approximations for nonlinear
hybrid systems. In: Alur R, Henzinger TA, Sontag E, eds. Hybrid Systems III:
Verification and Control. Vol 1066. Springer; 1996:377-388. doi:10.1007/BFb0020961'
apa: 'Henzinger, T. A., & Wong Toi, H. (1996). Linear phase-portrait approximations
for nonlinear hybrid systems. In R. Alur, T. A. Henzinger, & E. Sontag (Eds.),
Hybrid Systems III: Verification and Control (Vol. 1066, pp. 377–388).
Springer. https://doi.org/10.1007/BFb0020961'
chicago: 'Henzinger, Thomas A, and Howard Wong Toi. “Linear Phase-Portrait Approximations
for Nonlinear Hybrid Systems.” In Hybrid Systems III: Verification and Control,
edited by Rajeev Alur, Thomas A Henzinger, and Eduardo Sontag, 1066:377–88. Springer,
1996. https://doi.org/10.1007/BFb0020961.'
ieee: 'T. A. Henzinger and H. Wong Toi, “Linear phase-portrait approximations for
nonlinear hybrid systems,” in Hybrid Systems III: Verification and Control,
1996, vol. 1066, pp. 377–388.'
ista: 'Henzinger TA, Wong Toi H. 1996. Linear phase-portrait approximations for
nonlinear hybrid systems. Hybrid Systems III: Verification and Control. , LNCS,
vol. 1066, 377–388.'
mla: 'Henzinger, Thomas A., and Howard Wong Toi. “Linear Phase-Portrait Approximations
for Nonlinear Hybrid Systems.” Hybrid Systems III: Verification and Control,
edited by Rajeev Alur et al., vol. 1066, Springer, 1996, pp. 377–88, doi:10.1007/BFb0020961.'
short: 'T.A. Henzinger, H. Wong Toi, in:, R. Alur, T.A. Henzinger, E. Sontag (Eds.),
Hybrid Systems III: Verification and Control, Springer, 1996, pp. 377–388.'
date_created: 2018-12-11T12:08:47Z
date_published: 1996-01-01T00:00:00Z
date_updated: 2022-07-06T09:58:25Z
day: '01'
doi: 10.1007/BFb0020961
editor:
- first_name: Rajeev
full_name: Alur, Rajeev
last_name: Alur
- first_name: Thomas A
full_name: Henzinger, Thomas A
last_name: Henzinger
- first_name: Eduardo
full_name: Sontag, Eduardo
last_name: Sontag
extern: '1'
intvolume: ' 1066'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/chapter/10.1007/BFb0020961
month: '01'
oa_version: None
page: 377 - 388
publication: 'Hybrid Systems III: Verification and Control'
publication_identifier:
isbn:
- '9783540611554'
publication_status: published
publisher: Springer
publist_id: '302'
quality_controlled: '1'
status: public
title: Linear phase-portrait approximations for nonlinear hybrid systems
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1066
year: '1996'
...
---
_id: '4427'
abstract:
- lang: eng
text: We model a steam-boiler control system using hybrid automata. We provide two
abstracted linear models of the nonlinear behavior of the boiler. For each model,
we define and verify a controller that maintains safe operation of the boiler.
The less abstract model permits the design of a more efficient controller. We
also demonstrate how the tool HyTech can be used to automatically synthesize control
parameter constraints that guarantee safety of the boiler.
acknowledgement: This research was supported in part by the ONR YIP award N00014-95-1-0520,
by the NSF CAREER award CCR-9501708, by the NSF grant CCR-9504469, by the AFOSR
contract F49620-93-1-0056, and by the ARPA grant NAG2-892.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Howard
full_name: Wong Toi, Howard
last_name: Wong Toi
citation:
ama: 'Henzinger TA, Wong Toi H. Using HyTech to synthesize control parameters for
a steam boiler. In: Formal Methods for Industrial Applications: Specifying
and Programming the Steam Boiler Control. Vol 1165. Springer; 1996:265-282.
doi:10.1007/BFb0027241'
apa: 'Henzinger, T. A., & Wong Toi, H. (1996). Using HyTech to synthesize control
parameters for a steam boiler. In Formal Methods for Industrial Applications:
Specifying and Programming the Steam Boiler Control (Vol. 1165, pp. 265–282).
Springer. https://doi.org/10.1007/BFb0027241'
chicago: 'Henzinger, Thomas A, and Howard Wong Toi. “Using HyTech to Synthesize
Control Parameters for a Steam Boiler.” In Formal Methods for Industrial Applications:
Specifying and Programming the Steam Boiler Control, 1165:265–82. Springer,
1996. https://doi.org/10.1007/BFb0027241.'
ieee: 'T. A. Henzinger and H. Wong Toi, “Using HyTech to synthesize control parameters
for a steam boiler,” in Formal Methods for Industrial Applications: Specifying
and Programming the Steam Boiler Control, vol. 1165, Springer, 1996, pp. 265–282.'
ista: 'Henzinger TA, Wong Toi H. 1996.Using HyTech to synthesize control parameters
for a steam boiler. In: Formal Methods for Industrial Applications: Specifying
and Programming the Steam Boiler Control. LNCS, vol. 1165, 265–282.'
mla: 'Henzinger, Thomas A., and Howard Wong Toi. “Using HyTech to Synthesize Control
Parameters for a Steam Boiler.” Formal Methods for Industrial Applications:
Specifying and Programming the Steam Boiler Control, vol. 1165, Springer,
1996, pp. 265–82, doi:10.1007/BFb0027241.'
short: 'T.A. Henzinger, H. Wong Toi, in:, Formal Methods for Industrial Applications:
Specifying and Programming the Steam Boiler Control, Springer, 1996, pp. 265–282.'
date_created: 2018-12-11T12:08:48Z
date_published: 1996-01-01T00:00:00Z
date_updated: 2022-07-06T10:06:19Z
day: '01'
doi: 10.1007/BFb0027241
extern: '1'
intvolume: ' 1165'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/chapter/10.1007/BFb0027241
month: '01'
oa_version: None
page: 265 - 282
publication: 'Formal Methods for Industrial Applications: Specifying and Programming
the Steam Boiler Control'
publication_identifier:
isbn:
- '9783540495666'
publication_status: published
publisher: Springer
publist_id: '303'
quality_controlled: '1'
status: public
title: Using HyTech to synthesize control parameters for a steam boiler
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1165
year: '1996'
...
---
_id: '4443'
abstract:
- lang: eng
text: "Three natural equivalence relations on the infinite state space of a hybrid
automaton are language equivalence, simulation equivalence, and bisimulation equivalence.
When one of these equivalence relations has a finite quotient, certain model checking
and controller synthesis problems are decidable. When bounds on the number of
equivalence classes are obtained, bounds on the running times of model checking
and synthesis algorithms follow as corollaries.\r\nWe characterize the time-abstract
versions of these equivalence relations on the state spaces of rectangular hybrid
automata (RHA), in which each continuous variable is a clock with bounded drift.
These automata are useful for modeling communications protocols with drifting
local clocks, and for the conservative approximation of more complex hybrid systems.
Of our two main results, one has positive implications for automatic verification,
and the other has negative implications. On the positive side, we find that the
(finite) language equivalence quotient for RHA is coarser than was previously
known by a multiplicative exponential factor. On the negative side, we show that
simulation equivalence for RHA is equality (which obviously has an infinite quotient).\r\nOur
main positive result is established by analyzing a subclass of timed automata,
called one-sided timed automata (OTA), for which the language equivalence quotient
is coarser than for the class of all timed automata. An exact characterization
of language equivalence for OTA requires a distinction between synchronous and
asynchronous definitions of (bi)simulation: if time actions are silent, then the
induced quotient for OTA is coarser than if time actions (but not their durations)
are visible."
acknowledgement: This research was supported in part by ONR Young Investigator award
N00014-95-1-0520, by NSF CAREER award CCR-9501708, by NSF grant CCR-9504469, by
Air Force Office of Scientific Research contract F49620-93-1-0056, by ARPA grant
NAG2-892, and by the U.S. Army Research Office through the Mathematical Sciences
Institute of Cornell University, Contract Number DAAL03-91-C-0027.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Peter
full_name: Kopke, Peter
last_name: Kopke
citation:
ama: 'Henzinger TA, Kopke P. State equivalences for rectangular hybrid automata.
In: 7th International Conference on Concurrency Theory. Vol 1119. Schloss
Dagstuhl - Leibniz-Zentrum für Informatik; 1996:530-545. doi:10.1007/3-540-61604-7_74'
apa: 'Henzinger, T. A., & Kopke, P. (1996). State equivalences for rectangular
hybrid automata. In 7th International Conference on Concurrency Theory
(Vol. 1119, pp. 530–545). Pisa, Italy: Schloss Dagstuhl - Leibniz-Zentrum für
Informatik. https://doi.org/10.1007/3-540-61604-7_74'
chicago: Henzinger, Thomas A, and Peter Kopke. “State Equivalences for Rectangular
Hybrid Automata.” In 7th International Conference on Concurrency Theory,
1119:530–45. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 1996. https://doi.org/10.1007/3-540-61604-7_74.
ieee: T. A. Henzinger and P. Kopke, “State equivalences for rectangular hybrid automata,”
in 7th International Conference on Concurrency Theory, Pisa, Italy, 1996,
vol. 1119, pp. 530–545.
ista: 'Henzinger TA, Kopke P. 1996. State equivalences for rectangular hybrid automata.
7th International Conference on Concurrency Theory. CONCUR: Concurrency Theory,
LNCS, vol. 1119, 530–545.'
mla: Henzinger, Thomas A., and Peter Kopke. “State Equivalences for Rectangular
Hybrid Automata.” 7th International Conference on Concurrency Theory, vol.
1119, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 1996, pp. 530–45, doi:10.1007/3-540-61604-7_74.
short: T.A. Henzinger, P. Kopke, in:, 7th International Conference on Concurrency
Theory, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 1996, pp. 530–545.
conference:
end_date: 1996-08-29
location: Pisa, Italy
name: 'CONCUR: Concurrency Theory'
start_date: 1996-08-26
date_created: 2018-12-11T12:08:52Z
date_published: 1996-01-01T00:00:00Z
date_updated: 2022-07-06T08:43:23Z
day: '01'
doi: 10.1007/3-540-61604-7_74
extern: '1'
intvolume: ' 1119'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/chapter/10.1007/3-540-61604-7_74
month: '01'
oa_version: None
page: 530 - 545
publication: 7th International Conference on Concurrency Theory
publication_identifier:
isbn:
- '9783540616047'
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
publist_id: '288'
quality_controlled: '1'
status: public
title: State equivalences for rectangular hybrid automata
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1119
year: '1996'
...
---
_id: '4495'
abstract:
- lang: eng
text: In temporal-logic model checking, we verify the correctness of a program with
respect to a desired behavior by checking whether a structure that models the
program satisfies a temporal-logic formula that specifies the behavior. The main
practical limitation of model checking is caused by the size of the state space
of the program, which grows exponentially with the number of concurrent components.
This problem, known as the state-explosion problem, becomes more difficult when
we consider real-time model checking, where the program and the specification
involve quantitative references to time. In particular, when use timed automata
to describe real-time programs and we specify timed behaviors in the logic TCTL,
a real-time extension of the temporal logic CTL with clock variables, then the
state space under consideration grows exponentially not only with the number of
concurrent components, but also with the number of clocks and the length of the
clock constraints used in the program and the specification. Two powerful methods
for coping with the state-explosion problem are on-the-fly and space-efficient
model checking. In on-the-fly model checking, we explore only the portion of the
state space of the program whose exploration is essential for determining the
satisfaction of the specification. In space-efficient model checking, we store
in memory the minimal information required, preferring to spend time on reconstructing
information rather than spend space on storing it. In this work we develop an
automata-theoretic approach to TCTL model checking that combines both methods.
We suggest, for the first time, a PSPACE on-the-fly model-checking algorithm for
TCTL.
acknowledgement: Supported in part by the ONR YIP award N00014-95-1-0520, by the NSF
CAREER award CCR-9501708, by the NSF grant CCR-9504469, by the AFOSR contract F49620-93-1-0056,
and by the ARPA grant NAG2-892.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Orna
full_name: Kupferman, Orna
last_name: Kupferman
- first_name: Moshe
full_name: Vardi, Moshe
last_name: Vardi
citation:
ama: 'Henzinger TA, Kupferman O, Vardi M. A space-efficient on-the-fly algorithm
for real-time model checking. In: 7th International Conference on Concurrency
Theory. Vol 1119. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 1996:514-529.
doi:10.1007/3-540-61604-7_73'
apa: 'Henzinger, T. A., Kupferman, O., & Vardi, M. (1996). A space-efficient
on-the-fly algorithm for real-time model checking. In 7th International Conference
on Concurrency Theory (Vol. 1119, pp. 514–529). Pisa, Italy: Schloss Dagstuhl
- Leibniz-Zentrum für Informatik. https://doi.org/10.1007/3-540-61604-7_73'
chicago: Henzinger, Thomas A, Orna Kupferman, and Moshe Vardi. “A Space-Efficient
on-the-Fly Algorithm for Real-Time Model Checking.” In 7th International Conference
on Concurrency Theory, 1119:514–29. Schloss Dagstuhl - Leibniz-Zentrum für
Informatik, 1996. https://doi.org/10.1007/3-540-61604-7_73.
ieee: T. A. Henzinger, O. Kupferman, and M. Vardi, “A space-efficient on-the-fly
algorithm for real-time model checking,” in 7th International Conference on
Concurrency Theory, Pisa, Italy, 1996, vol. 1119, pp. 514–529.
ista: 'Henzinger TA, Kupferman O, Vardi M. 1996. A space-efficient on-the-fly algorithm
for real-time model checking. 7th International Conference on Concurrency Theory.
CONCUR: Concurrency Theory, LNCS, vol. 1119, 514–529.'
mla: Henzinger, Thomas A., et al. “A Space-Efficient on-the-Fly Algorithm for Real-Time
Model Checking.” 7th International Conference on Concurrency Theory, vol.
1119, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 1996, pp. 514–29, doi:10.1007/3-540-61604-7_73.
short: T.A. Henzinger, O. Kupferman, M. Vardi, in:, 7th International Conference
on Concurrency Theory, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 1996,
pp. 514–529.
conference:
end_date: 1996-08-29
location: Pisa, Italy
name: 'CONCUR: Concurrency Theory'
start_date: 1996-08-26
date_created: 2018-12-11T12:09:08Z
date_published: 1996-01-01T00:00:00Z
date_updated: 2022-07-06T08:21:20Z
day: '01'
doi: 10.1007/3-540-61604-7_73
extern: '1'
intvolume: ' 1119'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/chapter/10.1007/3-540-61604-7_73
month: '01'
oa_version: None
page: 514 - 529
publication: 7th International Conference on Concurrency Theory
publication_identifier:
isbn:
- 978-3-540-70625-0
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
publist_id: '233'
quality_controlled: '1'
status: public
title: A space-efficient on-the-fly algorithm for real-time model checking
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1119
year: '1996'
...
---
_id: '4519'
abstract:
- lang: eng
text: We summarize several recent results about hybrid automata. Our goal is to
demonstrate that concepts from the theory of discrete concurrent systems can give
insights into partly continuous systems, and that methods for the verification
of finite-state systems can be used to analyze certain systems with uncountable
state spaces
article_processing_charge: No
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
citation:
ama: 'Henzinger TA. The theory of hybrid automata. In: Proceedings 11th Annual
IEEE Symposium on Logic in Computer Science. IEEE; 1996:278-292. doi:10.1109/LICS.1996.561342 '
apa: 'Henzinger, T. A. (1996). The theory of hybrid automata. In Proceedings
11th Annual IEEE Symposium on Logic in Computer Science (pp. 278–292). New
Brunswick, NJ, United States of America: IEEE. https://doi.org/10.1109/LICS.1996.561342 '
chicago: Henzinger, Thomas A. “The Theory of Hybrid Automata.” In Proceedings
11th Annual IEEE Symposium on Logic in Computer Science, 278–92. IEEE, 1996.
https://doi.org/10.1109/LICS.1996.561342
.
ieee: T. A. Henzinger, “The theory of hybrid automata,” in Proceedings 11th Annual
IEEE Symposium on Logic in Computer Science, New Brunswick, NJ, United States
of America, 1996, pp. 278–292.
ista: 'Henzinger TA. 1996. The theory of hybrid automata. Proceedings 11th Annual
IEEE Symposium on Logic in Computer Science. LICS: Logic in Computer Science,
278–292.'
mla: Henzinger, Thomas A. “The Theory of Hybrid Automata.” Proceedings 11th Annual
IEEE Symposium on Logic in Computer Science, IEEE, 1996, pp. 278–92, doi:10.1109/LICS.1996.561342 .
short: T.A. Henzinger, in:, Proceedings 11th Annual IEEE Symposium on Logic in Computer
Science, IEEE, 1996, pp. 278–292.
conference:
end_date: 1996-07-30
location: New Brunswick, NJ, United States of America
name: 'LICS: Logic in Computer Science'
start_date: 1996-07-27
date_created: 2018-12-11T12:09:16Z
date_published: 1996-01-01T00:00:00Z
date_updated: 2022-07-06T07:56:28Z
day: '01'
doi: '10.1109/LICS.1996.561342 '
extern: '1'
language:
- iso: eng
main_file_link:
- url: https://ieeexplore.ieee.org/document/561342
month: '01'
oa_version: None
page: 278 - 292
publication: Proceedings 11th Annual IEEE Symposium on Logic in Computer Science
publication_identifier:
issn:
- 1043-6871
publication_status: published
publisher: IEEE
publist_id: '213'
quality_controlled: '1'
status: public
title: The theory of hybrid automata
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '1996'
...
---
_id: '4585'
alternative_title:
- LNCS
article_processing_charge: No
citation:
ama: Henzinger TA, Alur R, eds. 8th International Conference on Computer Aided
Verification. Vol 1102. Springer; 1996. doi:10.1007/3-540-61474-5
apa: 'Henzinger, T. A., & Alur, R. (Eds.). (1996). 8th International Conference
on Computer Aided Verification (Vol. 1102). Presented at the CAV: Computer
Aided Verification, New Brunswick, NJ, United States of America: Springer. https://doi.org/10.1007/3-540-61474-5'
chicago: Henzinger, Thomas A, and Rajeev Alur, eds. 8th International Conference
on Computer Aided Verification. Vol. 1102. Springer, 1996. https://doi.org/10.1007/3-540-61474-5.
ieee: T. A. Henzinger and R. Alur, Eds., 8th International Conference on Computer
Aided Verification, vol. 1102. Springer, 1996.
ista: Henzinger TA, Alur R eds. 1996. 8th International Conference on Computer
Aided Verification, Springer,p.
mla: Henzinger, Thomas A., and Rajeev Alur, editors. 8th International Conference
on Computer Aided Verification. Vol. 1102, Springer, 1996, doi:10.1007/3-540-61474-5.
short: T.A. Henzinger, R. Alur, eds., 8th International Conference on Computer
Aided Verification, Springer, 1996.
conference:
end_date: 1996-08-03
location: New Brunswick, NJ, United States of America
name: 'CAV: Computer Aided Verification'
start_date: 1996-07-31
date_created: 2018-12-11T12:09:36Z
date_published: 1996-01-01T00:00:00Z
date_updated: 2022-07-06T07:38:10Z
day: '01'
doi: 10.1007/3-540-61474-5
editor:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000-0002-2985-7724
- first_name: Rajeev
full_name: Alur, Rajeev
last_name: Alur
extern: '1'
intvolume: ' 1102'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/book/10.1007/3-540-61474-5
month: '01'
oa_version: None
publication_status: published
publisher: Springer
publist_id: '122'
status: public
title: ' 8th International Conference on Computer Aided Verification'
type: conference_editor
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1102
year: '1996'
...
---
_id: '4588'
abstract:
- lang: eng
text: 'We present a formal model for concurrent systems. The model represents synchronous
and asynchronous components in a uniform framework that supports compositional
(assume-guarantee) and hierarchical (stepwise refinement) reasoning. While synchronous
models are based on a notion of atomic computation step, and asynchronous models
remove that notion by introducing stuttering, our model is based on a flexible
notion of what constitutes a computation step: by applying an abstraction operator
to a system, arbitrarily many consecutive steps can be collapsed into a single
step. The abstraction operator, which may turn an asynchronous system into a synchronous
one, allows us to describe systems at various levels of temporal detail. For describing
systems at various levels of spatial detail, we use a hiding operator that may
turn a synchronous system into an asynchronous one. We illustrate the model with
diverse examples from synchronous circuits, asynchronous shared-memory programs,
and synchronous message passing'
article_processing_charge: No
author:
- first_name: Rajeev
full_name: Alur, Rajeev
last_name: Alur
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
citation:
ama: 'Alur R, Henzinger TA. Reactive modules. In: Proceedings 11th Annual IEEE
Symposium on Logic in Computer Science. IEEE; 1996:207-218. doi:10.1109/LICS.1996.561320'
apa: 'Alur, R., & Henzinger, T. A. (1996). Reactive modules. In Proceedings
11th Annual IEEE Symposium on Logic in Computer Science (pp. 207–218). New
Brunswick, NJ, USA: IEEE. https://doi.org/10.1109/LICS.1996.561320'
chicago: Alur, Rajeev, and Thomas A Henzinger. “Reactive Modules.” In Proceedings
11th Annual IEEE Symposium on Logic in Computer Science, 207–18. IEEE, 1996.
https://doi.org/10.1109/LICS.1996.561320.
ieee: R. Alur and T. A. Henzinger, “Reactive modules,” in Proceedings 11th Annual
IEEE Symposium on Logic in Computer Science, New Brunswick, NJ, USA, 1996,
pp. 207–218.
ista: 'Alur R, Henzinger TA. 1996. Reactive modules. Proceedings 11th Annual IEEE
Symposium on Logic in Computer Science. LICS: Logic in Computer Science, 207–218.'
mla: Alur, Rajeev, and Thomas A. Henzinger. “Reactive Modules.” Proceedings 11th
Annual IEEE Symposium on Logic in Computer Science, IEEE, 1996, pp. 207–18,
doi:10.1109/LICS.1996.561320.
short: R. Alur, T.A. Henzinger, in:, Proceedings 11th Annual IEEE Symposium on Logic
in Computer Science, IEEE, 1996, pp. 207–218.
conference:
end_date: 1996-07-30
location: New Brunswick, NJ, USA
name: 'LICS: Logic in Computer Science'
start_date: 1996-07-27
date_created: 2018-12-11T12:09:37Z
date_published: 1996-01-01T00:00:00Z
date_updated: 2022-07-04T14:51:40Z
day: '01'
doi: 10.1109/LICS.1996.561320
extern: '1'
language:
- iso: eng
main_file_link:
- url: https://ieeexplore.ieee.org/document/561320
month: '01'
oa_version: None
page: 207 - 218
publication: Proceedings 11th Annual IEEE Symposium on Logic in Computer Science
publication_identifier:
issn:
- 0018-9162
publication_status: published
publisher: IEEE
publist_id: '121'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Reactive modules
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '1996'
...
---
_id: '4611'
abstract:
- lang: eng
text: Presents a model-checking procedure and its implementation for the automatic
verification of embedded systems. The system components are described as hybrid
automata-communicating machines with finite control and real-valued variables
that represent continuous environment parameters such as time, pressure and temperature.
The system requirements are specified in a temporal logic with stop-watches, and
verified by symbolic fixpoint computation. The verification procedure-implemented
in the Cornell Hybrid Technology tool, HyTech-applies to hybrid automata whose
continuous dynamics is governed by linear constraints on the variables and their
derivatives. We illustrate the method and the tool by checking safety, liveness,
time-bounded and duration requirements of digital controllers, schedulers and
distributed algorithms
acknowledgement: "We thank Costas Courcoubetis, Nicolas Halbwachs, Peter Kopke, Joseph
Sifakis, and Howard Wong-Toi for helpful\r\ndiscussions and valuable comments. Thomas
A. Henzinger's research was supported in part by the U.S. Office of Naval Research
Young Investigator award N00014-95-1-0520, by the National Science Foundation CAREER
award CCR-9501708, by National Science Foundation grants CCR-9200794 and CCR-9504469,
by U.S. Air Force Office of Scientific Research contract F49620-93-1- 0056, and
by Advanced Research Projects Agency grant NAG2-892. "
article_processing_charge: No
article_type: original
author:
- first_name: Rajeev
full_name: Alur, Rajeev
last_name: Alur
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Pei
full_name: Ho, Pei
last_name: Ho
citation:
ama: Alur R, Henzinger TA, Ho P. Automatic symbolic verification of embedded systems.
IEEE Transactions on Software Engineering. 1996;22(3):181-201. doi:10.1109/32.489079
apa: Alur, R., Henzinger, T. A., & Ho, P. (1996). Automatic symbolic verification
of embedded systems. IEEE Transactions on Software Engineering. IEEE. https://doi.org/10.1109/32.489079
chicago: Alur, Rajeev, Thomas A Henzinger, and Pei Ho. “Automatic Symbolic Verification
of Embedded Systems.” IEEE Transactions on Software Engineering. IEEE,
1996. https://doi.org/10.1109/32.489079.
ieee: R. Alur, T. A. Henzinger, and P. Ho, “Automatic symbolic verification of embedded
systems,” IEEE Transactions on Software Engineering, vol. 22, no. 3. IEEE,
pp. 181–201, 1996.
ista: Alur R, Henzinger TA, Ho P. 1996. Automatic symbolic verification of embedded
systems. IEEE Transactions on Software Engineering. 22(3), 181–201.
mla: Alur, Rajeev, et al. “Automatic Symbolic Verification of Embedded Systems.”
IEEE Transactions on Software Engineering, vol. 22, no. 3, IEEE, 1996,
pp. 181–201, doi:10.1109/32.489079.
short: R. Alur, T.A. Henzinger, P. Ho, IEEE Transactions on Software Engineering
22 (1996) 181–201.
date_created: 2018-12-11T12:09:45Z
date_published: 1996-03-01T00:00:00Z
date_updated: 2022-07-04T12:47:05Z
day: '01'
doi: 10.1109/32.489079
extern: '1'
intvolume: ' 22'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://ecommons.cornell.edu/handle/1813/7170
month: '03'
oa: 1
oa_version: Published Version
page: 181 - 201
publication: IEEE Transactions on Software Engineering
publication_identifier:
issn:
- 0018-9162
publication_status: published
publisher: IEEE
publist_id: '96'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Automatic symbolic verification of embedded systems
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 22
year: '1996'
...
---
_id: '4610'
abstract:
- lang: eng
text: The most natural, compositional, way of modeling real-time systems uses a
dense domain for time. The satisfiability of timing constraints that are capable
of expressing punctuality in this model, however, is known to be undecidable.
We introduce a temporal language that can constrain the time difference between
events only with finite, yet arbitrary, precision and show the resulting logic
to be EXPSPACE-complete. This result allows us to develop an algorithm for the
verification of timing properties of real-time systems with a dense semantics.
acknowledgement: 'We wish to thank an anonymous referee for pointing out the PSPACE-fragment
of Section 4.5. '
article_processing_charge: No
article_type: original
author:
- first_name: Rajeev
full_name: Alur, Rajeev
last_name: Alur
- first_name: Tomás
full_name: Feder, Tomás
last_name: Feder
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
citation:
ama: Alur R, Feder T, Henzinger TA. The benefits of relaxing punctuality. Journal
of the ACM. 1996;43(1):116-146. doi:10.1145/227595.227602
apa: Alur, R., Feder, T., & Henzinger, T. A. (1996). The benefits of relaxing
punctuality. Journal of the ACM. ACM. https://doi.org/10.1145/227595.227602
chicago: Alur, Rajeev, Tomás Feder, and Thomas A Henzinger. “The Benefits of Relaxing
Punctuality.” Journal of the ACM. ACM, 1996. https://doi.org/10.1145/227595.227602.
ieee: R. Alur, T. Feder, and T. A. Henzinger, “The benefits of relaxing punctuality,”
Journal of the ACM, vol. 43, no. 1. ACM, pp. 116–146, 1996.
ista: Alur R, Feder T, Henzinger TA. 1996. The benefits of relaxing punctuality.
Journal of the ACM. 43(1), 116–146.
mla: Alur, Rajeev, et al. “The Benefits of Relaxing Punctuality.” Journal of
the ACM, vol. 43, no. 1, ACM, 1996, pp. 116–46, doi:10.1145/227595.227602.
short: R. Alur, T. Feder, T.A. Henzinger, Journal of the ACM 43 (1996) 116–146.
date_created: 2018-12-11T12:09:44Z
date_published: 1996-01-01T00:00:00Z
date_updated: 2022-07-04T12:38:01Z
day: '01'
doi: 10.1145/227595.227602
extern: '1'
intvolume: ' 43'
issue: '1'
language:
- iso: eng
main_file_link:
- url: https://dl.acm.org/doi/10.1145/227595.227602
month: '01'
oa_version: None
page: 116 - 146
publication: Journal of the ACM
publication_identifier:
issn:
- 0004-5411
publication_status: published
publisher: ACM
publist_id: '95'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The benefits of relaxing punctuality
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 43
year: '1996'
...
---
_id: '4612'
alternative_title:
- LNCS
article_processing_charge: No
citation:
ama: 'Alur R, Henzinger TA, Sontag ED, eds. Hybrid Systems III: Verification
and Control. Vol 1066. Berlin ; Heidelberg: Springer; 1996. doi:10.1007/BFb0020931'
apa: 'Alur, R., Henzinger, T. A., & Sontag, E. D. (Eds.). (1996). Hybrid
Systems III: Verification and Control (Vol. 1066). Berlin ; Heidelberg: Springer.
https://doi.org/10.1007/BFb0020931'
chicago: 'Alur, Rajeev, Thomas A Henzinger, and Eduardo D Sontag, eds. Hybrid
Systems III: Verification and Control. Vol. 1066. Lecture Notes in Computer
Science. Berlin ; Heidelberg: Springer, 1996. https://doi.org/10.1007/BFb0020931.'
ieee: 'R. Alur, T. A. Henzinger, and E. D. Sontag, Eds., Hybrid Systems III:
Verification and Control, vol. 1066. Berlin ; Heidelberg: Springer, 1996.'
ista: 'Alur R, Henzinger TA, Sontag ED eds. 1996. Hybrid Systems III: Verification
and Control, Berlin ; Heidelberg: Springer, IX, 619p.'
mla: 'Alur, Rajeev, et al., editors. Hybrid Systems III: Verification and Control.
Vol. 1066, Springer, 1996, doi:10.1007/BFb0020931.'
short: 'R. Alur, T.A. Henzinger, E.D. Sontag, eds., Hybrid Systems III: Verification
and Control, Springer, Berlin ; Heidelberg, 1996.'
date_created: 2018-12-11T12:09:45Z
date_published: 1996-01-01T00:00:00Z
date_updated: 2021-12-22T13:57:33Z
day: '01'
doi: 10.1007/BFb0020931
editor:
- first_name: Rajeev
full_name: Alur, Rajeev
last_name: Alur
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Eduardo D
full_name: Sontag, Eduardo D
last_name: Sontag
extern: '1'
intvolume: ' 1066'
language:
- iso: eng
month: '01'
oa_version: None
page: IX, 619
place: Berlin ; Heidelberg
publication_identifier:
isbn:
- 978-3-540-61155-4
issn:
- 0302-9743
publication_status: published
publisher: Springer
publist_id: '97'
quality_controlled: '1'
series_title: Lecture Notes in Computer Science
status: public
title: 'Hybrid Systems III: Verification and Control'
type: book_editor
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 1066
year: '1996'
...
---
_id: '6161'
abstract:
- lang: eng
text: 'The tra-1 gene is a terminal regulator of somatic sex in Caenorhabditis elegans:
high tra-1 activity elicits female development, low tra-1 activity elicits male
development. To investigate the function and evolution of tra- 1, we examined
the tra-1 gene from the closely related nematode C. briggsae. Ce-tra-1 and Cb-tra-1
are unusually divergent. Each gene generates two transcripts, but only one of
these is present in both species. This common transcript encodes TRA-1A, which
shows only 44% amino acid identity between the species, a figure much lower than
that for previously compared genes. A Cb-tra-1 transgene rescues many tissues
of tra-1(null) mutants of C. elegans but not the somatic gonad or germ line. This
transgene also causes nongonadal feminization of XO animals, indicating incorrect
sexual regulation. Alignment of Ce-TRA-1A and Cb-TRA-1A defined several conserved
regions likely to be important for tra-1 function. The phenotype differences between
Ce-tra- 1(null) mutants rescued by Cb-tra-1 transgenes and wild-type C. elegans
indicate significant divergence of regulatory regions. These molecular and functional
studies suggest that evolution of sex determination in nematodes is rapid and
genetically complex.'
author:
- first_name: Mario
full_name: de Bono, Mario
id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87
last_name: de Bono
orcid: 0000-0001-8347-0443
- first_name: J.
full_name: Hodgkin, J.
last_name: Hodgkin
citation:
ama: 'de Bono M, Hodgkin J. Evolution of sex determination in Caenorhabditis: Unusually
high divergence of tra-1 and its functional consequences. Genetics. 1996;144(2):587-595.'
apa: 'de Bono, M., & Hodgkin, J. (1996). Evolution of sex determination in Caenorhabditis:
Unusually high divergence of tra-1 and its functional consequences. Genetics.
Genetics Society of America.'
chicago: 'Bono, Mario de, and J. Hodgkin. “Evolution of Sex Determination in Caenorhabditis:
Unusually High Divergence of Tra-1 and Its Functional Consequences.” Genetics.
Genetics Society of America, 1996.'
ieee: 'M. de Bono and J. Hodgkin, “Evolution of sex determination in Caenorhabditis:
Unusually high divergence of tra-1 and its functional consequences,” Genetics,
vol. 144, no. 2. Genetics Society of America, pp. 587–595, 1996.'
ista: 'de Bono M, Hodgkin J. 1996. Evolution of sex determination in Caenorhabditis:
Unusually high divergence of tra-1 and its functional consequences. Genetics.
144(2), 587–595.'
mla: 'de Bono, Mario, and J. Hodgkin. “Evolution of Sex Determination in Caenorhabditis:
Unusually High Divergence of Tra-1 and Its Functional Consequences.” Genetics,
vol. 144, no. 2, Genetics Society of America, 1996, pp. 587–95.'
short: M. de Bono, J. Hodgkin, Genetics 144 (1996) 587–595.
date_created: 2019-03-21T11:50:37Z
date_published: 1996-10-01T00:00:00Z
date_updated: 2021-01-12T08:06:28Z
day: '01'
extern: '1'
external_id:
pmid:
- '8889522'
intvolume: ' 144'
issue: '2'
keyword:
- amino acid sequence
- article
- caenorhabditis elegans
- evolution
- genetic variability
- nonhuman
- priority journal
- sex determination
- Amino Acid Sequence
- Animals
- Animals
- Genetically Modified
- Base Sequence
- Caenorhabditis
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- DNA
- Helminth
- DNA-Binding Proteins
- Evolution
- Molecular
- Female
- Helminth Proteins
- Membrane Proteins
- Molecular Sequence Data
- Mutagenesis
- RNA
- Messenger
- Sequence Homology
- Amino Acid
- Sex Determination (Analysis)
- Transcription Factors
- Transgenes
- Turner Syndrome
- Animalia
- Caenorhabditis
- Caenorhabditis briggsae
- Caenorhabditis elegans
- Nematoda
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1207552/
month: '10'
oa: 1
oa_version: Published Version
page: 587-595
pmid: 1
publication: Genetics
publication_identifier:
issn:
- '00166731'
publication_status: published
publisher: Genetics Society of America
quality_controlled: '1'
status: public
title: 'Evolution of sex determination in Caenorhabditis: Unusually high divergence
of tra-1 and its functional consequences'
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 144
year: '1996'
...