---
_id: '11666'
abstract:
- lang: eng
text: This article describes the Digital Continuous Profiling Infrastructure, a
sampling-based profiling system designed to run continuously on production systems.
The system supports multiprocessors, works on unmodified executables, and collects
profiles for entire systems, including user programs, shared libraries, and the
operating system kernel. Samples are collected at a high rate (over 5200 samples/sec.
per 333MHz processor), yet with low overhead (1–3% slowdown for most workloads).
Analysis tools supplied with the profiling system use the sample data to produce
a precise and accurate accounting, down to the level of pipeline stalls incurred
by individual instructions, of where time is bring spent. When instructions incur
stalls, the tools identify possible reasons, such as cache misses, branch mispredictions,
and functional unit contention. The fine-grained instruction-level analysis guides
users and automated optimizers to the causes of performance problems and provides
important insights for fixing them.
acknowledgement: We would like to thank Mike Burrows, Allan Heydon, Hal Murray, Sharon
Perl, and Sharon Smith for helpful comments that greatly improved the content and
presentation of this article; the anonymous referees for SOSP and TOCS also provided
numerous helpful comments. We would also like to thank Dawson Engler for initially
suggesting the use of interprocessor interrupts to avoid expensive synchronization
operations in the interrupt handler, Mitch Lichtenberg for his work on the Alpha/NT
version of our system and in general for his help and suggestions on the project,
and the developers of iprobe for supplying us with source code that helped us get
off the ground in building the early versions of our data collection system. Finally,
we would like to thank Gary Carleton and Bob Davies of Intel for answering our questions
about VTune and Marty Itzkowitz of SGI for answering our questions about SpeedShop.
article_processing_charge: No
article_type: original
author:
- first_name: Jennifer M.
full_name: Anderson, Jennifer M.
last_name: Anderson
- first_name: Lance M.
full_name: Berc, Lance M.
last_name: Berc
- first_name: Jeffrey
full_name: Dean, Jeffrey
last_name: Dean
- first_name: Sanjay
full_name: Ghemawat, Sanjay
last_name: Ghemawat
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Shun-Tak A.
full_name: Leung, Shun-Tak A.
last_name: Leung
- first_name: Richard L.
full_name: Sites, Richard L.
last_name: Sites
- first_name: Mark T.
full_name: Vandevoorde, Mark T.
last_name: Vandevoorde
- first_name: Carl A.
full_name: Waldspurger, Carl A.
last_name: Waldspurger
- first_name: William E.
full_name: Weihl, William E.
last_name: Weihl
citation:
ama: 'Anderson JM, Berc LM, Dean J, et al. Continuous profiling: Where have all
the cycles gone? ACM Transactions on Computer Systems. 1997;15(4):357-390.
doi:10.1145/265924.265925'
apa: 'Anderson, J. M., Berc, L. M., Dean, J., Ghemawat, S., Henzinger, M. H., Leung,
S.-T. A., … Weihl, W. E. (1997). Continuous profiling: Where have all the cycles
gone? ACM Transactions on Computer Systems. Association for Computing Machinery.
https://doi.org/10.1145/265924.265925'
chicago: 'Anderson, Jennifer M., Lance M. Berc, Jeffrey Dean, Sanjay Ghemawat, Monika
H Henzinger, Shun-Tak A. Leung, Richard L. Sites, Mark T. Vandevoorde, Carl A.
Waldspurger, and William E. Weihl. “Continuous Profiling: Where Have All the Cycles
Gone?” ACM Transactions on Computer Systems. Association for Computing
Machinery, 1997. https://doi.org/10.1145/265924.265925.'
ieee: 'J. M. Anderson et al., “Continuous profiling: Where have all the cycles
gone?,” ACM Transactions on Computer Systems, vol. 15, no. 4. Association
for Computing Machinery, pp. 357–390, 1997.'
ista: 'Anderson JM, Berc LM, Dean J, Ghemawat S, Henzinger MH, Leung S-TA, Sites
RL, Vandevoorde MT, Waldspurger CA, Weihl WE. 1997. Continuous profiling: Where
have all the cycles gone? ACM Transactions on Computer Systems. 15(4), 357–390.'
mla: 'Anderson, Jennifer M., et al. “Continuous Profiling: Where Have All the Cycles
Gone?” ACM Transactions on Computer Systems, vol. 15, no. 4, Association
for Computing Machinery, 1997, pp. 357–90, doi:10.1145/265924.265925.'
short: J.M. Anderson, L.M. Berc, J. Dean, S. Ghemawat, M.H. Henzinger, S.-T.A. Leung,
R.L. Sites, M.T. Vandevoorde, C.A. Waldspurger, W.E. Weihl, ACM Transactions on
Computer Systems 15 (1997) 357–390.
date_created: 2022-07-27T11:42:25Z
date_published: 1997-11-01T00:00:00Z
date_updated: 2022-09-09T12:00:13Z
day: '01'
doi: 10.1145/265924.265925
extern: '1'
intvolume: ' 15'
issue: '4'
language:
- iso: eng
month: '11'
oa_version: None
page: 357-390
publication: ACM Transactions on Computer Systems
publication_identifier:
eissn:
- 1557-7333
issn:
- 0734-2071
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Continuous profiling: Where have all the cycles gone?'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 15
year: '1997'
...
---
_id: '11767'
abstract:
- lang: eng
text: We give a linear-time algorithm for single-source shortest paths in planar
graphs with nonnegative edge-lengths. Our algorithm also yields a linear-time
algorithm for maximum flow in a planar graph with the source and sink on the same
face. For the case where negative edge-lengths are allowed, we give an algorithm
requiringO(n4/3 log(nL)) time, whereLis the absolute value of the most negative
length. This algorithm can be used to obtain similar bounds for computing a feasible
flow in a planar network, for finding a perfect matching in a planar bipartite
graph, and for finding a maximum flow in a planar graph when the source and sink
are not on the same face. We also give parallel and dynamic versions of these
algorithms.
article_processing_charge: No
article_type: original
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Philip
full_name: Klein, Philip
last_name: Klein
- first_name: Satish
full_name: Rao, Satish
last_name: Rao
- first_name: Sairam
full_name: Subramanian, Sairam
last_name: Subramanian
citation:
ama: Henzinger MH, Klein P, Rao S, Subramanian S. Faster shortest-path algorithms
for planar graphs. Journal of Computer and System Sciences. 1997;55(1):3-23.
doi:10.1006/jcss.1997.1493
apa: Henzinger, M. H., Klein, P., Rao, S., & Subramanian, S. (1997). Faster
shortest-path algorithms for planar graphs. Journal of Computer and System
Sciences. Elsevier. https://doi.org/10.1006/jcss.1997.1493
chicago: Henzinger, Monika H, Philip Klein, Satish Rao, and Sairam Subramanian.
“Faster Shortest-Path Algorithms for Planar Graphs.” Journal of Computer and
System Sciences. Elsevier, 1997. https://doi.org/10.1006/jcss.1997.1493.
ieee: M. H. Henzinger, P. Klein, S. Rao, and S. Subramanian, “Faster shortest-path
algorithms for planar graphs,” Journal of Computer and System Sciences,
vol. 55, no. 1. Elsevier, pp. 3–23, 1997.
ista: Henzinger MH, Klein P, Rao S, Subramanian S. 1997. Faster shortest-path algorithms
for planar graphs. Journal of Computer and System Sciences. 55(1), 3–23.
mla: Henzinger, Monika H., et al. “Faster Shortest-Path Algorithms for Planar Graphs.”
Journal of Computer and System Sciences, vol. 55, no. 1, Elsevier, 1997,
pp. 3–23, doi:10.1006/jcss.1997.1493.
short: M.H. Henzinger, P. Klein, S. Rao, S. Subramanian, Journal of Computer and
System Sciences 55 (1997) 3–23.
date_created: 2022-08-08T12:28:45Z
date_published: 1997-08-01T00:00:00Z
date_updated: 2022-09-12T10:46:21Z
day: '01'
doi: 10.1006/jcss.1997.1493
extern: '1'
intvolume: ' 55'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1006/jcss.1997.1493
month: '08'
oa: 1
oa_version: Published Version
page: 3-23
publication: Journal of Computer and System Sciences
publication_identifier:
issn:
- 0022-0000
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Faster shortest-path algorithms for planar graphs
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 55
year: '1997'
...
---
_id: '11765'
abstract:
- lang: eng
text: This paper presents insertions-only algorithms for maintaining the exact and/or
approximate size of the minimum edge cut and the minimum vertex cut of a graph.
The algorithms output the approximate or exact sizekin timeO(1) and a cut of sizekin
time linear in its size. For the minimum edge cut problem and for any 0 < ε ≤
1, the amortized time per insertion isO(1/ε2) for a (2 + ε)-approximation,O((log
λ)((log n)/ε)2) for a (1 + ε)-approximation, andO(λ log n) for the exact size,
wherenis the number of nodes in the graph and λ is the size of the minimum cut.
The (2 + ε)-approximation algorithm and the exact algorithm are deterministic;
the (1 + ε)-approximation algorithm is randomized. We also present a static 2-approximation
algorithm for the size κ of the minimum vertex cut in a graph, which takes time.
This is a factor of κ faster than the best algorithm for computing the exact size,
which takes time. We give an insertions-only algorithm for maintaining a (2 +
ε)-approximation of the minimum vertex cut with amortized insertion timeO(n/ε).
article_processing_charge: No
article_type: original
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
citation:
ama: Henzinger MH. A static 2-approximation algorithm for vertex connectivity and
incremental approximation algorithms for edge and vertex connectivity. Journal
of Algorithms. 1997;24(1):194-220. doi:10.1006/jagm.1997.0855
apa: Henzinger, M. H. (1997). A static 2-approximation algorithm for vertex connectivity
and incremental approximation algorithms for edge and vertex connectivity. Journal
of Algorithms. Elsevier. https://doi.org/10.1006/jagm.1997.0855
chicago: Henzinger, Monika H. “A Static 2-Approximation Algorithm for Vertex Connectivity
and Incremental Approximation Algorithms for Edge and Vertex Connectivity.” Journal
of Algorithms. Elsevier, 1997. https://doi.org/10.1006/jagm.1997.0855.
ieee: M. H. Henzinger, “A static 2-approximation algorithm for vertex connectivity
and incremental approximation algorithms for edge and vertex connectivity,” Journal
of Algorithms, vol. 24, no. 1. Elsevier, pp. 194–220, 1997.
ista: Henzinger MH. 1997. A static 2-approximation algorithm for vertex connectivity
and incremental approximation algorithms for edge and vertex connectivity. Journal
of Algorithms. 24(1), 194–220.
mla: Henzinger, Monika H. “A Static 2-Approximation Algorithm for Vertex Connectivity
and Incremental Approximation Algorithms for Edge and Vertex Connectivity.” Journal
of Algorithms, vol. 24, no. 1, Elsevier, 1997, pp. 194–220, doi:10.1006/jagm.1997.0855.
short: M.H. Henzinger, Journal of Algorithms 24 (1997) 194–220.
date_created: 2022-08-08T12:18:38Z
date_published: 1997-07-01T00:00:00Z
date_updated: 2022-09-12T09:15:38Z
day: '01'
doi: 10.1006/jagm.1997.0855
extern: '1'
intvolume: ' 24'
issue: '1'
language:
- iso: eng
month: '07'
oa_version: None
page: 194-220
publication: Journal of Algorithms
publication_identifier:
issn:
- 0196-6774
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: A static 2-approximation algorithm for vertex connectivity and incremental
approximation algorithms for edge and vertex connectivity
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 24
year: '1997'
...
---
_id: '11803'
abstract:
- lang: eng
text: We present the first fully dynamic algorithm for maintaining a minimum spanning
tree in time o(√n) per operation. To be precise, the algorithm uses O(n 1/3 log
n) amortized time per update operation. The algorithm is fairly simple and deterministic.
An immediate consequence is the first fully dynamic deterministic algorithm for
maintaining connectivity and, bipartiteness in amortized time O(n 1/3 log n) per
update, with O(1) worst case time per query.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Valerie
full_name: King, Valerie
last_name: King
citation:
ama: 'Henzinger MH, King V. Maintaining minimum spanning trees in dynamic graphs.
In: 24th International Colloquium on Automata, Languages and Programming.
Vol 1256. Springer Nature; 1997:594–604. doi:10.1007/3-540-63165-8_214'
apa: 'Henzinger, M. H., & King, V. (1997). Maintaining minimum spanning trees
in dynamic graphs. In 24th International Colloquium on Automata, Languages
and Programming (Vol. 1256, pp. 594–604). Bologna, Italy: Springer Nature.
https://doi.org/10.1007/3-540-63165-8_214'
chicago: Henzinger, Monika H, and Valerie King. “Maintaining Minimum Spanning Trees
in Dynamic Graphs.” In 24th International Colloquium on Automata, Languages
and Programming, 1256:594–604. Springer Nature, 1997. https://doi.org/10.1007/3-540-63165-8_214.
ieee: M. H. Henzinger and V. King, “Maintaining minimum spanning trees in dynamic
graphs,” in 24th International Colloquium on Automata, Languages and Programming,
Bologna, Italy, 1997, vol. 1256, pp. 594–604.
ista: 'Henzinger MH, King V. 1997. Maintaining minimum spanning trees in dynamic
graphs. 24th International Colloquium on Automata, Languages and Programming.
ICALP: International Colloquium on Automata, Languages, and Programming, LNCS,
vol. 1256, 594–604.'
mla: Henzinger, Monika H., and Valerie King. “Maintaining Minimum Spanning Trees
in Dynamic Graphs.” 24th International Colloquium on Automata, Languages and
Programming, vol. 1256, Springer Nature, 1997, pp. 594–604, doi:10.1007/3-540-63165-8_214.
short: M.H. Henzinger, V. King, in:, 24th International Colloquium on Automata,
Languages and Programming, Springer Nature, 1997, pp. 594–604.
conference:
end_date: 1997-07-11
location: Bologna, Italy
name: 'ICALP: International Colloquium on Automata, Languages, and Programming'
start_date: 1997-07-07
date_created: 2022-08-11T13:35:06Z
date_published: 1997-07-01T00:00:00Z
date_updated: 2023-02-14T07:49:03Z
day: '01'
doi: 10.1007/3-540-63165-8_214
extern: '1'
intvolume: ' 1256'
language:
- iso: eng
month: '07'
oa_version: None
page: 594–604
publication: 24th International Colloquium on Automata, Languages and Programming
publication_identifier:
eisbn:
- '9783540691945'
eissn:
- 1611-3349
isbn:
- '9783540631651'
issn:
- 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Maintaining minimum spanning trees in dynamic graphs
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 1256
year: '1997'
...
---
_id: '11849'
abstract:
- lang: eng
text: "This paper describes the DIGlTAL Continuous Profiling Infrastmcture, a sampling-based
profiling system designed to run continuously on production systems. The system
supports multiprocessors, works on unmodified executable& and collects profiles
for entire systems, including user programs, shared libraries, and the operating
system kernel. Samples are collected at a high rate (over 5200 samples/secper333-MHz
processor), yet with low overhead (l-3% slowdown for most workloads). Analysis
tools supplied with the profiling system use the sample data to produce an accurate
accounting, down to the level of pipeline stalls incurred by individual instructions,
of where time is being spent. When instructions incur stalls, the tools identify
possible reasons, such as cache misses, branch mispredictions, and functional
unit contention. The fine-grained instruction-level analysis guides users and
automated optimizers to the causes of performance\r\nproblems and provides important
insights for fixing them. "
article_processing_charge: No
article_type: original
author:
- first_name: Jennifer M.
full_name: Anderson, Jennifer M.
last_name: Anderson
- first_name: Lance M.
full_name: Berc, Lance M.
last_name: Berc
- first_name: Jeffrey
full_name: Dean, Jeffrey
last_name: Dean
- first_name: Sanjay
full_name: Ghemawat, Sanjay
last_name: Ghemawat
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Shun-Tak A.
full_name: Leung, Shun-Tak A.
last_name: Leung
- first_name: Richard L.
full_name: Sites, Richard L.
last_name: Sites
- first_name: Mark T.
full_name: Vandevoorde, Mark T.
last_name: Vandevoorde
- first_name: Carl A.
full_name: Waldspurger, Carl A.
last_name: Waldspurger
- first_name: William E.
full_name: Weihl, William E.
last_name: Weihl
citation:
ama: 'Anderson JM, Berc LM, Dean J, et al. Continuous profiling: Where have all
the cycles gone? ACM SIGOPS Operating Systems Review. 1997;31(5):1-14.
doi:10.1145/269005.266637'
apa: 'Anderson, J. M., Berc, L. M., Dean, J., Ghemawat, S., Henzinger, M. H., Leung,
S.-T. A., … Weihl, W. E. (1997). Continuous profiling: Where have all the cycles
gone? ACM SIGOPS Operating Systems Review. Association for Computing Machinery.
https://doi.org/10.1145/269005.266637'
chicago: 'Anderson, Jennifer M., Lance M. Berc, Jeffrey Dean, Sanjay Ghemawat, Monika
H Henzinger, Shun-Tak A. Leung, Richard L. Sites, Mark T. Vandevoorde, Carl A.
Waldspurger, and William E. Weihl. “Continuous Profiling: Where Have All the Cycles
Gone?” ACM SIGOPS Operating Systems Review. Association for Computing Machinery,
1997. https://doi.org/10.1145/269005.266637.'
ieee: 'J. M. Anderson et al., “Continuous profiling: Where have all the cycles
gone?,” ACM SIGOPS Operating Systems Review, vol. 31, no. 5. Association
for Computing Machinery, pp. 1–14, 1997.'
ista: 'Anderson JM, Berc LM, Dean J, Ghemawat S, Henzinger MH, Leung S-TA, Sites
RL, Vandevoorde MT, Waldspurger CA, Weihl WE. 1997. Continuous profiling: Where
have all the cycles gone? ACM SIGOPS Operating Systems Review. 31(5), 1–14.'
mla: 'Anderson, Jennifer M., et al. “Continuous Profiling: Where Have All the Cycles
Gone?” ACM SIGOPS Operating Systems Review, vol. 31, no. 5, Association
for Computing Machinery, 1997, pp. 1–14, doi:10.1145/269005.266637.'
short: J.M. Anderson, L.M. Berc, J. Dean, S. Ghemawat, M.H. Henzinger, S.-T.A. Leung,
R.L. Sites, M.T. Vandevoorde, C.A. Waldspurger, W.E. Weihl, ACM SIGOPS Operating
Systems Review 31 (1997) 1–14.
date_created: 2022-08-16T07:07:03Z
date_published: 1997-12-01T00:00:00Z
date_updated: 2023-02-21T16:30:27Z
day: '01'
doi: 10.1145/269005.266637
extern: '1'
intvolume: ' 31'
issue: '5'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1145/269005.266637
month: '12'
oa: 1
oa_version: Published Version
page: 1-14
publication: ACM SIGOPS Operating Systems Review
publication_identifier:
issn:
- 0163-5980
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
related_material:
record:
- id: '11849'
relation: earlier_version
status: public
scopus_import: '1'
status: public
title: 'Continuous profiling: Where have all the cycles gone?'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 31
year: '1997'
...
---
_id: '11883'
abstract:
- lang: eng
text: 'In dynamic graph algorithms the following provide-or-bound problem has to
be solved quickly: Given a set S containing a subset R and a way of generating
random elements from S testing for membership in R, either (i) provide an element
of R, or (ii) give a (small) upper bound on the size of R that holds with high
probability. We give an optimal algorithm for this problem. This algorithm improves
the time per operation for various dynamic graph algorithms by a factor of O(log n).
For example, it improves the time per update for fully dynamic connectivity from
O(log3n) to O(log2n).'
article_processing_charge: No
article_type: original
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Mikkel
full_name: Thorup, Mikkel
last_name: Thorup
citation:
ama: 'Henzinger MH, Thorup M. Sampling to provide or to bound: With applications
to fully dynamic graph algorithms. Random Structures and Algorithms. 1997;11(4):369-379.
doi:10.1002/(sici)1098-2418(199712)11:4<369::aid-rsa5>3.0.co;2-x'
apa: 'Henzinger, M. H., & Thorup, M. (1997). Sampling to provide or to bound:
With applications to fully dynamic graph algorithms. Random Structures and
Algorithms. Wiley. https://doi.org/10.1002/(sici)1098-2418(199712)11:4<369::aid-rsa5>3.0.co;2-x'
chicago: 'Henzinger, Monika H, and Mikkel Thorup. “Sampling to Provide or to Bound:
With Applications to Fully Dynamic Graph Algorithms.” Random Structures and
Algorithms. Wiley, 1997. https://doi.org/10.1002/(sici)1098-2418(199712)11:4<369::aid-rsa5>3.0.co;2-x.'
ieee: 'M. H. Henzinger and M. Thorup, “Sampling to provide or to bound: With applications
to fully dynamic graph algorithms,” Random Structures and Algorithms, vol.
11, no. 4. Wiley, pp. 369–379, 1997.'
ista: 'Henzinger MH, Thorup M. 1997. Sampling to provide or to bound: With applications
to fully dynamic graph algorithms. Random Structures and Algorithms. 11(4), 369–379.'
mla: 'Henzinger, Monika H., and Mikkel Thorup. “Sampling to Provide or to Bound:
With Applications to Fully Dynamic Graph Algorithms.” Random Structures and
Algorithms, vol. 11, no. 4, Wiley, 1997, pp. 369–79, doi:10.1002/(sici)1098-2418(199712)11:4<369::aid-rsa5>3.0.co;2-x.'
short: M.H. Henzinger, M. Thorup, Random Structures and Algorithms 11 (1997) 369–379.
date_created: 2022-08-17T07:21:55Z
date_published: 1997-12-07T00:00:00Z
date_updated: 2023-02-17T14:05:02Z
day: '07'
doi: 10.1002/(sici)1098-2418(199712)11:4<369::aid-rsa5>3.0.co;2-x
extern: '1'
intvolume: ' 11'
issue: '4'
language:
- iso: eng
month: '12'
oa_version: None
page: 369-379
publication: Random Structures and Algorithms
publication_identifier:
eissn:
- 1098-2418
issn:
- 1042-9832
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Sampling to provide or to bound: With applications to fully dynamic graph
algorithms'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 11
year: '1997'
...
---
_id: '2493'
abstract:
- lang: eng
text: 'A specific antiserum against substance P receptor (SPR) labels nonprincipal
neurons in the cerebral cortex of the rat (T. Kaneko et al. [1994], Neuroscience
60:199-211; Y. Nakaya et al. [1994], J. Comp. Neurol. 347:249-274). In the present
study, we aimed to identify the types of SPR- immunoreactive neurons in the hippocampus
according to their content of neurochemical markers, which label interneuron populations
with distinct termination patterns. Markers for perisomatic inhibitory cells,
parvalbumin and cholecystokinin (CCK), colocalized with SPR in pyramidallike basket
cells in the dentate gyrus and in large multipolar or bitufted cells within all
hippocampal subfields respectively. A dense meshwork of SPR-immunoreactive spiny
dendrites in the hilus and stratum lucidum of the CA3 region belonged largely
to inhibitory cells terminating in the distal dendritic region of granule cells,
as indicated by the somatostatin and neuropeptide Y (NPY) content. In addition,
SPR and NPY were colocalized in numerous multipolar interneurons with dendrites
branching close to the soma. Twenty-five percent of the SPR-immunoreactive cells
overlapped with calretinin-positive neurons in all hippocampal subfields, showing
that interneurons specialized to contact other gamma-aminobutyric acid-ergic cells
may also contain SPR. On the basis of the known termination pattern of the colocalized
markers, we conclude that SPR-positive interneurons are functionally heterogeneous
and participate in different inhibitory processes: (1) perisomatic inhibition
of principal cells (CCK-containing cells, and parvalbumin-positive cells in the
dentate gyrus), (2) feedback dendritic inhibition in the entorhinal termination
zone (somatostatin and NPY-containing cells), and (3) innervation of other interneurons
(calretinin-containing cells).'
acknowledgement: This sudy was supported by grants from the Human Frontier Science
Program Organisation, the Howard Hughes Medical Institute, and OTKA (T 16942) Hungary.We
are grateful to Dr. K.G. Baimbridge and to Dr. M.R.Celio (calbindin and parvalbumin),
Dr. T. Go ̈rcs (CCK, VIP,NPY, and somatostatin), Dr. J.H. Rogers (calretinin), andDr.
C.G. Beaulieau (GABA) for kind gifts of antisera. The excellent technical assistance
of Mrs. E. Borok, Mrs. A.Z.Szabo, and Mr. G. Terstyanszky is also acknowledged
article_processing_charge: No
article_type: original
author:
- first_name: László
full_name: Acsády, László
last_name: Acsády
- first_name: István
full_name: Katona, István
last_name: Katona
- first_name: Attila
full_name: Gulyás, Attila
last_name: Gulyás
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Tamás
full_name: Freund, Tamás
last_name: Freund
citation:
ama: Acsády L, Katona I, Gulyás A, Shigemoto R, Freund T. Immunostaining for substance
P receptor labels GABAergic cells with distinct termination patterns in the hippocampus.
Journal of Comparative Neurology. 1997;378(3):320-336. doi:10.1002/(SICI)1096-9861(19970217)378:3<320::AID-CNE2>3.0.CO;2-5
apa: Acsády, L., Katona, I., Gulyás, A., Shigemoto, R., & Freund, T. (1997).
Immunostaining for substance P receptor labels GABAergic cells with distinct termination
patterns in the hippocampus. Journal of Comparative Neurology. Wiley-Blackwell.
https://doi.org/10.1002/(SICI)1096-9861(19970217)378:3<320::AID-CNE2>3.0.CO;2-5
chicago: Acsády, László, István Katona, Attila Gulyás, Ryuichi Shigemoto, and Tamás
Freund. “Immunostaining for Substance P Receptor Labels GABAergic Cells with Distinct
Termination Patterns in the Hippocampus.” Journal of Comparative Neurology.
Wiley-Blackwell, 1997. https://doi.org/10.1002/(SICI)1096-9861(19970217)378:3<320::AID-CNE2>3.0.CO;2-5.
ieee: L. Acsády, I. Katona, A. Gulyás, R. Shigemoto, and T. Freund, “Immunostaining
for substance P receptor labels GABAergic cells with distinct termination patterns
in the hippocampus,” Journal of Comparative Neurology, vol. 378, no. 3.
Wiley-Blackwell, pp. 320–336, 1997.
ista: Acsády L, Katona I, Gulyás A, Shigemoto R, Freund T. 1997. Immunostaining
for substance P receptor labels GABAergic cells with distinct termination patterns
in the hippocampus. Journal of Comparative Neurology. 378(3), 320–336.
mla: Acsády, László, et al. “Immunostaining for Substance P Receptor Labels GABAergic
Cells with Distinct Termination Patterns in the Hippocampus.” Journal of Comparative
Neurology, vol. 378, no. 3, Wiley-Blackwell, 1997, pp. 320–36, doi:10.1002/(SICI)1096-9861(19970217)378:3<320::AID-CNE2>3.0.CO;2-5.
short: L. Acsády, I. Katona, A. Gulyás, R. Shigemoto, T. Freund, Journal of Comparative
Neurology 378 (1997) 320–336.
date_created: 2018-12-11T11:57:59Z
date_published: 1997-02-17T00:00:00Z
date_updated: 2022-08-22T13:43:18Z
day: '17'
doi: 10.1002/(SICI)1096-9861(19970217)378:3<320::AID-CNE2>3.0.CO;2-5
extern: '1'
external_id:
pmid:
- '9034894'
intvolume: ' 378'
issue: '3'
language:
- iso: eng
month: '02'
oa_version: None
page: 320 - 336
pmid: 1
publication: Journal of Comparative Neurology
publication_identifier:
issn:
- 0021-9967
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4408'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Immunostaining for substance P receptor labels GABAergic cells with distinct
termination patterns in the hippocampus
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 378
year: '1997'
...
---
_id: '2576'
abstract:
- lang: eng
text: Primary afferent neurons containing substance P (SP) are apparently implicated
in the transmission of noxious information from the periphery to the central nervous
system, and SP released from primary afferent neurons acts on second-order neurons
with the SP receptor (SPR). In the rat, nociceptive information reached the hypothalamus
not only through indirect pathways but also directly through trigeminohypothalamic
and spinohypothalamic pathways. Thus, in the present study, the distribution pattern
of trigeminohypothalamic and spinohypothalamic tract neurons showing SPR-like
immunoreactivity (SPR-LI) was examined in the rat by a retrograde tract-tracing
method combined with immunofluorescence histochemistry for SPR. A substantial
number of trigeminal and spinal neurons with SPR-LI were retrogradely labeled
with Fluore-Gold (FG) injected into the hypothalamic regions. These neurons were
distributed mainly in lamina I of the medullary and spinal dorsal horns, lateral
spinal nucleus, regions around the central canal of the spinal cord, and the lateral
aspect of the deep part of the spinal dorsal horn. A number of SPR-LI neurons
in the spinal parasympathetic nucleus were labeled with FG injected into the area
around the paraventricular hypothalamic nucleus. Some SPR-LI neurons in the lateral
spinal nucleus and the lateral aspect of the deep part of the spinal dorsal horn
were also labeled with FG injected into the septal region. On the basis of the
distribution areas of SPR-LI trigeminal and spinal neurons projecting to the hypothalamic
and septal regions, it is likely that these neurons are involved in the transmission
of somatic and/or visceral noxious information.
acknowledgement: This study was supported by grants 08279106 and 08458245 from the
Ministry of Education, Science, Sportsand Culture of Japan. We are grateful for
the photographic help of Mr. Akira Uesugi and the support of Dr. Kajitaro Morita
in Morita Clinic of Internal Medicine and Pediatrics, Kadoma, Osaka, Japan. We also
express our gratitude for the support of Drs. Satoru Fukuchi, Ritsu Hayashi,Sohzaburo
Hayashi, Mizuho Katsurada, Hitoski Kawai,Yutaka Kitani, Toshihiko Kuroda, Keiko
Kumagai, Hiroshi Matsubara, Hiroshi Matsushima, Chisato Minakuchi,Gonpei Niwa, Hajime
Oda, Mashiko Ohbayashi, Seiichi Ohbayashi, Hiroyasu Ohtsuka, Shigeo Tamaki, EizoWatanabe,
Kazuo Yoshino, and Toshiaki Yoshino.
article_processing_charge: No
article_type: original
author:
- first_name: Jin
full_name: Li, Jin
last_name: Li
- first_name: Takeshi
full_name: Kaneko, Takeshi
last_name: Kaneko
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Li J, Kaneko T, Shigemoto R, Mizuno N. Distribution of trigeminohypothalamic
and spinohypothalamic tract neurons displaying substance P receptor-like immunoreactivity
in the rat. Journal of Comparative Neurology. 1997;378(4):508-521. doi:10.1002/(SICI)1096-9861(19970224)378:4<508::AID-CNE6>3.0.CO;2-6
apa: Li, J., Kaneko, T., Shigemoto, R., & Mizuno, N. (1997). Distribution of
trigeminohypothalamic and spinohypothalamic tract neurons displaying substance
P receptor-like immunoreactivity in the rat. Journal of Comparative Neurology.
Wiley-Blackwell. https://doi.org/10.1002/(SICI)1096-9861(19970224)378:4<508::AID-CNE6>3.0.CO;2-6
chicago: Li, Jin, Takeshi Kaneko, Ryuichi Shigemoto, and Noboru Mizuno. “Distribution
of Trigeminohypothalamic and Spinohypothalamic Tract Neurons Displaying Substance
P Receptor-like Immunoreactivity in the Rat.” Journal of Comparative Neurology.
Wiley-Blackwell, 1997. https://doi.org/10.1002/(SICI)1096-9861(19970224)378:4<508::AID-CNE6>3.0.CO;2-6.
ieee: J. Li, T. Kaneko, R. Shigemoto, and N. Mizuno, “Distribution of trigeminohypothalamic
and spinohypothalamic tract neurons displaying substance P receptor-like immunoreactivity
in the rat,” Journal of Comparative Neurology, vol. 378, no. 4. Wiley-Blackwell,
pp. 508–521, 1997.
ista: Li J, Kaneko T, Shigemoto R, Mizuno N. 1997. Distribution of trigeminohypothalamic
and spinohypothalamic tract neurons displaying substance P receptor-like immunoreactivity
in the rat. Journal of Comparative Neurology. 378(4), 508–521.
mla: Li, Jin, et al. “Distribution of Trigeminohypothalamic and Spinohypothalamic
Tract Neurons Displaying Substance P Receptor-like Immunoreactivity in the Rat.”
Journal of Comparative Neurology, vol. 378, no. 4, Wiley-Blackwell, 1997,
pp. 508–21, doi:10.1002/(SICI)1096-9861(19970224)378:4<508::AID-CNE6>3.0.CO;2-6.
short: J. Li, T. Kaneko, R. Shigemoto, N. Mizuno, Journal of Comparative Neurology
378 (1997) 508–521.
date_created: 2018-12-11T11:58:28Z
date_published: 1997-02-24T00:00:00Z
date_updated: 2022-08-22T13:34:53Z
day: '24'
doi: 10.1002/(SICI)1096-9861(19970224)378:4<508::AID-CNE6>3.0.CO;2-6
extern: '1'
external_id:
pmid:
- '9034907'
intvolume: ' 378'
issue: '4'
language:
- iso: eng
month: '02'
oa_version: None
page: 508 - 521
pmid: 1
publication: Journal of Comparative Neurology
publication_identifier:
issn:
- 0021-9967
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4323'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Distribution of trigeminohypothalamic and spinohypothalamic tract neurons displaying
substance P receptor-like immunoreactivity in the rat
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 378
year: '1997'
...
---
_id: '2578'
abstract:
- lang: eng
text: The distribution of immunoreactivity to the neurokinin3 receptor (NK3R) was
examined in segments C7, T11-12, L1-2, and L4-6 of the rat spinal cord. NK3R immunoreactivity
was visualized by using two antisera generated against sequences of amino acids
contained in the C-terminal region of the NK3R. NK3R-immunoreactive cells were
numerous in the substantia gelatinosa of all spinal segments examined as well
as the dorsal commissural nucleus of spinal segments L1-2. Isolated, immunoreactive
cells were scattered throughout other regions of the spinal cord. The relationship
of NK3R-immunoreactivity with neurons was demonstrated by colocalization with
microtubule associated protein 2-immunoreactivity in individual cells. Within
neurons, NK3R- immunoreactivity was associated predominately with the plasma membrane
of cell bodies and dendrites. Within the substantia gelatinosa, 86% of nitric
oxide synthase (NOS)-immunoreactive neurons were also NK3R-immunoreactive. Although
NOS-immunoreactive neurons were found throughout all other regions of the spinal
cord in the segments examined, these were not NK3R- immunoreactive. When preganglionic
sympathetic neurons in spinal segments T11-12 and L1-2 were visualized by intraperitoneal
injection of Fluorogold, less than 1% of the Fluorogold-labeled neurons were also
immunoreactive for NK3R. The large number of NK3R-immunoreactive neurons in the
substantia gelatinosa suggests that some effects of tachykinins an somatosensation
may be mediated by NK3R.
acknowledgement: The authors are grateful to Dr. Colin Anderson fordiscussions of
the organization of spinal autonomic nuclei.V.S.S. was a visiting research fellow
in the Department ofAnatomy and Cell Biology, University of Melbourne.
article_processing_charge: No
article_type: original
author:
- first_name: Virginia
full_name: Seybold, Virginia
last_name: Seybold
- first_name: Ivica
full_name: Grković, Ivica
last_name: Grković
- first_name: Andrea
full_name: Portbury, Andrea
last_name: Portbury
- first_name: Yu
full_name: Ding, Yu
last_name: Ding
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
- first_name: John
full_name: Furness, John
last_name: Furness
- first_name: Bridget
full_name: Southwell, Bridget
last_name: Southwell
citation:
ama: Seybold V, Grković I, Portbury A, et al. Relationship of NK3 receptor-immunoreactivity
to subpopulations of neurons in rat spinal cord. Journal of Comparative Neurology.
1997;381(4):439-448. doi:10.1002/(SICI)1096-9861(19970519)381:4<439::AID-CNE4>3.0.CO;2-3
apa: Seybold, V., Grković, I., Portbury, A., Ding, Y., Shigemoto, R., Mizuno, N.,
… Southwell, B. (1997). Relationship of NK3 receptor-immunoreactivity to subpopulations
of neurons in rat spinal cord. Journal of Comparative Neurology. Wiley-Blackwell.
https://doi.org/10.1002/(SICI)1096-9861(19970519)381:4<439::AID-CNE4>3.0.CO;2-3
chicago: Seybold, Virginia, Ivica Grković, Andrea Portbury, Yu Ding, Ryuichi Shigemoto,
Noboru Mizuno, John Furness, and Bridget Southwell. “Relationship of NK3 Receptor-Immunoreactivity
to Subpopulations of Neurons in Rat Spinal Cord.” Journal of Comparative Neurology.
Wiley-Blackwell, 1997. https://doi.org/10.1002/(SICI)1096-9861(19970519)381:4<439::AID-CNE4>3.0.CO;2-3.
ieee: V. Seybold et al., “Relationship of NK3 receptor-immunoreactivity to
subpopulations of neurons in rat spinal cord,” Journal of Comparative Neurology,
vol. 381, no. 4. Wiley-Blackwell, pp. 439–448, 1997.
ista: Seybold V, Grković I, Portbury A, Ding Y, Shigemoto R, Mizuno N, Furness J,
Southwell B. 1997. Relationship of NK3 receptor-immunoreactivity to subpopulations
of neurons in rat spinal cord. Journal of Comparative Neurology. 381(4), 439–448.
mla: Seybold, Virginia, et al. “Relationship of NK3 Receptor-Immunoreactivity to
Subpopulations of Neurons in Rat Spinal Cord.” Journal of Comparative Neurology,
vol. 381, no. 4, Wiley-Blackwell, 1997, pp. 439–48, doi:10.1002/(SICI)1096-9861(19970519)381:4<439::AID-CNE4>3.0.CO;2-3.
short: V. Seybold, I. Grković, A. Portbury, Y. Ding, R. Shigemoto, N. Mizuno, J.
Furness, B. Southwell, Journal of Comparative Neurology 381 (1997) 439–448.
date_created: 2018-12-11T11:58:29Z
date_published: 1997-05-19T00:00:00Z
date_updated: 2022-08-22T12:27:14Z
day: '19'
doi: 10.1002/(SICI)1096-9861(19970519)381:4<439::AID-CNE4>3.0.CO;2-3
extern: '1'
external_id:
pmid:
- '9136801 '
intvolume: ' 381'
issue: '4'
language:
- iso: eng
month: '05'
oa_version: None
page: 439 - 448
pmid: 1
publication: Journal of Comparative Neurology
publication_identifier:
issn:
- 0021-9967
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4320'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Relationship of NK3 receptor-immunoreactivity to subpopulations of neurons
in rat spinal cord
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 381
year: '1997'
...
---
_id: '2575'
abstract:
- lang: eng
text: It was examined electron microscopically in the rat if a metabotropic glutamate
receptor, mGluR7, might be localized in axon terminals of nociceptive, primary
afferent fibers in laminae I and II of the spinal dorsal horn. Nociceptive nature
of axon terminals showing mGluR7-like immunoreactivity (mGluR7-LI) was indicated
by binding to the isolectin I-B4 from Griffonia simplicifolia (I-B4), or by substance
P-like immunoreactivity (SP-LI). Axon terminals labeled with immunogold particles
indicating mGluR7-LI were usually filled with round synaptic vesicles and were
in asymmetric synaptic contact with dendritic or somatic profiles; occasionally
they contained pleomorphic vesicles and were in symmetric synaptic contact with
somatic profiles in lamina II. The double-labeling studies revealed that most
of axon terminals with I-B4 labeling as well as a small population of axon terminals
with SP-LI, showed mGluR7-LI. About one-third or much smaller population of axon
terminals with mGluR7-LI in laminae I and II were labeled, respectively, with
I-B4 or SP-LI; these were in asymmetric synaptic contact with dendritic profiles.
acknowledgement: We are grateful for photographic help of Mr. Akira Uesugi. We also
express our gratitude for the support of Drs. Satoru Fukuchi, Ritsu Hayashi, Sohzaburo
Hayashi, Mizuho Katsurada, Hitoshi Kawai, Yutaka Kitani, Toshihiko Kuroda, Keiko
Kumagai, Hiroshi Matsubara, Hiroshi Matsushima, Chisato Minakuchi, Gonpei Niwa,
Hajime Oda, Masahiko Ohbayashi, Sei-ichi Ohbayashi, Hiroyasu Ohtsuka, Shigeo Tamaki,
Eizo Watanabe, Kazuo Yoshino, and Toshiaki Yoshino. This work was supported in part
by Grant-in-Aid from Ministry of Education, Science, Culture and Sports of Japan.
article_processing_charge: No
article_type: original
author:
- first_name: He
full_name: Li, He
last_name: Li
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Ayae
full_name: Kinoshita, Ayae
last_name: Kinoshita
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Sakashi
full_name: Nomura, Sakashi
last_name: Nomura
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: 'Li H, Ohishi H, Kinoshita A, Shigemoto R, Nomura S, Mizuno N. Localization
of a metabotropic glutamate receptor, mGluR7, in axon terminals of presumed nociceptive,
primary afferent fibers in the superficial layers of the spinal dorsal horn: An
electron microscope study in the rat. Neuroscience Letters. 1997;223(3):153-156.
doi:10.1016/S0304-3940(97)13429-2'
apa: 'Li, H., Ohishi, H., Kinoshita, A., Shigemoto, R., Nomura, S., & Mizuno,
N. (1997). Localization of a metabotropic glutamate receptor, mGluR7, in axon
terminals of presumed nociceptive, primary afferent fibers in the superficial
layers of the spinal dorsal horn: An electron microscope study in the rat. Neuroscience
Letters. Elsevier. https://doi.org/10.1016/S0304-3940(97)13429-2'
chicago: 'Li, He, Hitoshi Ohishi, Ayae Kinoshita, Ryuichi Shigemoto, Sakashi Nomura,
and Noboru Mizuno. “Localization of a Metabotropic Glutamate Receptor, MGluR7,
in Axon Terminals of Presumed Nociceptive, Primary Afferent Fibers in the Superficial
Layers of the Spinal Dorsal Horn: An Electron Microscope Study in the Rat.” Neuroscience
Letters. Elsevier, 1997. https://doi.org/10.1016/S0304-3940(97)13429-2.'
ieee: 'H. Li, H. Ohishi, A. Kinoshita, R. Shigemoto, S. Nomura, and N. Mizuno, “Localization
of a metabotropic glutamate receptor, mGluR7, in axon terminals of presumed nociceptive,
primary afferent fibers in the superficial layers of the spinal dorsal horn: An
electron microscope study in the rat,” Neuroscience Letters, vol. 223,
no. 3. Elsevier, pp. 153–156, 1997.'
ista: 'Li H, Ohishi H, Kinoshita A, Shigemoto R, Nomura S, Mizuno N. 1997. Localization
of a metabotropic glutamate receptor, mGluR7, in axon terminals of presumed nociceptive,
primary afferent fibers in the superficial layers of the spinal dorsal horn: An
electron microscope study in the rat. Neuroscience Letters. 223(3), 153–156.'
mla: 'Li, He, et al. “Localization of a Metabotropic Glutamate Receptor, MGluR7,
in Axon Terminals of Presumed Nociceptive, Primary Afferent Fibers in the Superficial
Layers of the Spinal Dorsal Horn: An Electron Microscope Study in the Rat.” Neuroscience
Letters, vol. 223, no. 3, Elsevier, 1997, pp. 153–56, doi:10.1016/S0304-3940(97)13429-2.'
short: H. Li, H. Ohishi, A. Kinoshita, R. Shigemoto, S. Nomura, N. Mizuno, Neuroscience
Letters 223 (1997) 153–156.
date_created: 2018-12-11T11:58:28Z
date_published: 1997-02-28T00:00:00Z
date_updated: 2022-08-22T13:06:30Z
day: '28'
doi: 10.1016/S0304-3940(97)13429-2
extern: '1'
external_id:
pmid:
- '9080455'
intvolume: ' 223'
issue: '3'
language:
- iso: eng
month: '02'
oa_version: None
page: 153 - 156
pmid: 1
publication: Neuroscience Letters
publication_identifier:
issn:
- 0304-3940
publication_status: published
publisher: Elsevier
publist_id: '4322'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Localization of a metabotropic glutamate receptor, mGluR7, in axon terminals
of presumed nociceptive, primary afferent fibers in the superficial layers of the
spinal dorsal horn: An electron microscope study in the rat'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 223
year: '1997'
...
---
_id: '2577'
abstract:
- lang: eng
text: The cloned cDNA for rat prostacyclin synthase was found to contain a 1503-bp
open reading frame which encoded a 501-amino acid protein sharing 84% identity
with the human enzyme. RNA blot analysis revealed that the rat prostacyclin synthase
mRNA, as a single species of 2.1 kb, is expressed abundantly in the aorta and
uterus. High levels of expression were also observed in the stomach, lung, heart,
testis, liver, and skeletal muscle. Low but significant expression was also seen
in the brain and kidney. Furthermore, the regional distribution and cellular localization
of prostacyclin synthase mRNA were examined by in situ hybridization analysis
of rat tissue sections. The definitive signals for the mRNA were localized in
smooth muscle cells of the arteries, bronchi and uterus, and in the cells of the
fibrous tunic surrounding the seminiferous tubules, which are characterized as
smooth muscle cells. Besides smooth muscle cells, signal were also detected in
the fibroblasts of the heart myocardium, lung parenchyma cells and kidney inner
medulla tubules and interstitial cells.
article_processing_charge: No
article_type: original
author:
- first_name: Yoshinori
full_name: Tone, Yoshinori
last_name: Tone
- first_name: Hiroyasu
full_name: Inoue, Hiroyasu
last_name: Inoue
- first_name: Shuntaro
full_name: Hara, Shuntaro
last_name: Hara
- first_name: Chieko
full_name: Yokoyama, Chieko
last_name: Yokoyama
- first_name: Toshihisa
full_name: Hatae, Toshihisa
last_name: Hatae
- first_name: Hiroji
full_name: Oida, Hiroji
last_name: Oida
- first_name: Shuh
full_name: Narumiya, Shuh
last_name: Narumiya
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Susumu
full_name: Yukawa, Susumu
last_name: Yukawa
- first_name: Tadashi
full_name: Tanabe, Tadashi
last_name: Tanabe
citation:
ama: Tone Y, Inoue H, Hara S, et al. The regional distribution and cellular localization
of mRNA encoding rat prostacyclin synthase. European Journal of Cell Biology.
1997;72(3):268-277.
apa: Tone, Y., Inoue, H., Hara, S., Yokoyama, C., Hatae, T., Oida, H., … Tanabe,
T. (1997). The regional distribution and cellular localization of mRNA encoding
rat prostacyclin synthase. European Journal of Cell Biology. Elsevier.
chicago: Tone, Yoshinori, Hiroyasu Inoue, Shuntaro Hara, Chieko Yokoyama, Toshihisa
Hatae, Hiroji Oida, Shuh Narumiya, Ryuichi Shigemoto, Susumu Yukawa, and Tadashi
Tanabe. “The Regional Distribution and Cellular Localization of MRNA Encoding
Rat Prostacyclin Synthase.” European Journal of Cell Biology. Elsevier,
1997.
ieee: Y. Tone et al., “The regional distribution and cellular localization
of mRNA encoding rat prostacyclin synthase,” European Journal of Cell Biology,
vol. 72, no. 3. Elsevier, pp. 268–277, 1997.
ista: Tone Y, Inoue H, Hara S, Yokoyama C, Hatae T, Oida H, Narumiya S, Shigemoto
R, Yukawa S, Tanabe T. 1997. The regional distribution and cellular localization
of mRNA encoding rat prostacyclin synthase. European Journal of Cell Biology.
72(3), 268–277.
mla: Tone, Yoshinori, et al. “The Regional Distribution and Cellular Localization
of MRNA Encoding Rat Prostacyclin Synthase.” European Journal of Cell Biology,
vol. 72, no. 3, Elsevier, 1997, pp. 268–77.
short: Y. Tone, H. Inoue, S. Hara, C. Yokoyama, T. Hatae, H. Oida, S. Narumiya,
R. Shigemoto, S. Yukawa, T. Tanabe, European Journal of Cell Biology 72 (1997)
268–277.
date_created: 2018-12-11T11:58:29Z
date_published: 1997-03-01T00:00:00Z
date_updated: 2022-08-22T12:50:04Z
day: '01'
extern: '1'
external_id:
pmid:
- '9084989 '
intvolume: ' 72'
issue: '3'
language:
- iso: eng
month: '03'
oa_version: None
page: 268 - 277
pmid: 1
publication: European Journal of Cell Biology
publication_identifier:
issn:
- 0171-9335
publication_status: published
publisher: Elsevier
publist_id: '4321'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The regional distribution and cellular localization of mRNA encoding rat prostacyclin
synthase
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 72
year: '1997'
...
---
_id: '2580'
abstract:
- lang: eng
text: Two group I metabotropic glutamate receptor subtypes, mGluR1 and mGluR5, have
been reported to occur in highest concentration in an annulus surrounding the
edge of the postsynaptic membrane specialisation. In order to determine whether
such a distribution is uniform amongst postsynaptic mGluRs, their distribution
was compared quantitatively by a pre-embedding silver-intensified immunogold technique
at electron microscopic level in hippocampal pyramidal cells (mGluR5), cerebellar
Purkinje cells (mGluR1α) and Golgi cells (mGluR2). The results show that mGluR1α,
mGluR5 and mGluR2 each have a distinct distribution in relation to the glutamatergic
synaptic junctions. On dendritic spines, mGluRlα and mGluR5 showed the highest
receptor density in a perisynaptic annulus (defined as within 60 nm of the edge
of the synapse) followed by a decreasing extrasynaptic (60-900 nm) receptor level,
but the gradient of decrease and the proportion of the perisynaptic pool (mGluR1α,
~ 50%; vs mGluR5, ~ 25%) were different for the two receptors. The distributions
of mGluRlα and mGluR5 also differed significantly from simulated random distributions.
In contrast, mGluR2 was not closely associated with glutamatergic synapses in
the dendritic plasma membrane of cerebellar Golgi cells and its distribution relative
to synapses is not different from simulated random distribution in the membrane.
The somatic membrane, the axon and the synaptic boutons of the GABAergic Golgi
cells also contained immunoreactive mGluR2 that is not associated with synaptic
specialisations. In the hippocampal CA1 area the distribution of immunoparticles
for mGluR5 on individual spines was established using serial sections. The results
indicate that dendritic spines of pyramidal cells are heterogeneous with respect
to the ratio of perisynaptic to extrasynaptic mGluR5 pools and about half of the
immunopositive spines lack the perisynaptic pool. The quantitative comparison
of receptor distributions demonstrates that mGluRlα and mGluR5, but not mGluR2,
are highly compartmentalised in different plasma membrane domains. The unique
distribution of each mGluR subtype may reflect requirements for different transduction
and effector mechanisms between cell types and different domains of the same cell,
and suggests that the precise placement of receptors is a crucial factor contributing
to neuronal communication.
acknowledgement: The authors are grateful to Dr Tibor Szilagyi and Mr Laszlo Marton
for advice, helpful discussions, providing the simulations of receptor distribution
and the cylindrical approximation of dendritic surface (L.M.). The brain of a mGluR2
deficient mouse was kindly provided by Drs M. Yokoi and S. Nakanishi for testing
of the specificity of one of the antibodies. The authors also thank Dr Jeff McIlhinney
for critical comments and Dr Zoltan Nusser for help with the statistics, for helpful
discussion during the project and for his comments on an earlier version of the
manuscript. The technical assistance of Ms Zahida Ahmad and the photographic assistance
of Mr Frank Kennedy, Mr Paul Jays and Mr Akira Uesugi are acknowledged. This work
was partly supported by grants from the Japan Society for the Promotion of Science,
the British Council and the Royal Society.
article_processing_charge: No
article_type: original
author:
- first_name: Rafael
full_name: Luján, Rafael
last_name: Luján
- first_name: John
full_name: Roberts, John
last_name: Roberts
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Péter
full_name: Somogyi, Péter
last_name: Somogyi
citation:
ama: Luján R, Roberts J, Shigemoto R, Ohishi H, Somogyi P. Differential plasma membrane
distribution of metabotropic glutamate receptors mGluR1α, mGluR2 and mGluR5, relative
to neurotransmitter release sites. Journal of Chemical Neuroanatomy. 1997;13(4):219-241.
doi:10.1016/S0891-0618(97)00051-3
apa: Luján, R., Roberts, J., Shigemoto, R., Ohishi, H., & Somogyi, P. (1997).
Differential plasma membrane distribution of metabotropic glutamate receptors
mGluR1α, mGluR2 and mGluR5, relative to neurotransmitter release sites. Journal
of Chemical Neuroanatomy. Elsevier. https://doi.org/10.1016/S0891-0618(97)00051-3
chicago: Luján, Rafael, John Roberts, Ryuichi Shigemoto, Hitoshi Ohishi, and Péter
Somogyi. “Differential Plasma Membrane Distribution of Metabotropic Glutamate
Receptors MGluR1α, MGluR2 and MGluR5, Relative to Neurotransmitter Release Sites.”
Journal of Chemical Neuroanatomy. Elsevier, 1997. https://doi.org/10.1016/S0891-0618(97)00051-3.
ieee: R. Luján, J. Roberts, R. Shigemoto, H. Ohishi, and P. Somogyi, “Differential
plasma membrane distribution of metabotropic glutamate receptors mGluR1α, mGluR2
and mGluR5, relative to neurotransmitter release sites,” Journal of Chemical
Neuroanatomy, vol. 13, no. 4. Elsevier, pp. 219–241, 1997.
ista: Luján R, Roberts J, Shigemoto R, Ohishi H, Somogyi P. 1997. Differential plasma
membrane distribution of metabotropic glutamate receptors mGluR1α, mGluR2 and
mGluR5, relative to neurotransmitter release sites. Journal of Chemical Neuroanatomy.
13(4), 219–241.
mla: Luján, Rafael, et al. “Differential Plasma Membrane Distribution of Metabotropic
Glutamate Receptors MGluR1α, MGluR2 and MGluR5, Relative to Neurotransmitter Release
Sites.” Journal of Chemical Neuroanatomy, vol. 13, no. 4, Elsevier, 1997,
pp. 219–41, doi:10.1016/S0891-0618(97)00051-3.
short: R. Luján, J. Roberts, R. Shigemoto, H. Ohishi, P. Somogyi, Journal of Chemical
Neuroanatomy 13 (1997) 219–241.
date_created: 2018-12-11T11:58:30Z
date_published: 1997-10-04T00:00:00Z
date_updated: 2022-08-22T12:12:03Z
day: '04'
doi: 10.1016/S0891-0618(97)00051-3
extern: '1'
external_id:
pmid:
- '9412905'
intvolume: ' 13'
issue: '4'
language:
- iso: eng
month: '10'
oa_version: None
page: 219 - 241
pmid: 1
publication: Journal of Chemical Neuroanatomy
publication_identifier:
issn:
- 0891-0618
publication_status: published
publisher: Elsevier
publist_id: '4318'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Differential plasma membrane distribution of metabotropic glutamate receptors
mGluR1α, mGluR2 and mGluR5, relative to neurotransmitter release sites
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 13
year: '1997'
...
---
_id: '2582'
abstract:
- lang: eng
text: 'Neurotransmission in the hippocampus is modulated variously through presynaptic
metabotropic glutamate receptors (mGluRs). To establish the precise localization
of presynaptic mGluRs in the rat hippocampus, we used subtype-specific antibodies
for eight mGluRs (mGluR1-mGluR8) for immunohistochemistry combined with lesioning
of the three major hippocampal pathways: the perforant path, mossy fiber, and
Schaffer collateral. Immunoreactivity for group II (mGluR2) and group III (mGluR4a,
mGluR7a, mGluR7b, and mGluR8) mGluRs was predominantly localized to presynaptic
elements, whereas that for group I mGluRs (mGluR1 and mGluR5) was localized to
postsynaptic elements. The medial perforant path was strongly immunoreactive for
mGluR2 and mGluR7a throughout the hippocampus, and the lateral perforant path
was prominently immunoreactive for mGluR8 in the dentate gyrus and CA3 area. The
messy fiber was labeled for mGluR2, mGluR7a, and mGluR7b, whereas the Schaffer
collateral was labeled only for mGluR7a. Electron microscopy further revealed
the spatial segregation of group II and group III mGluRs within presynaptic elements.
Immunolabeling for the group III receptors was predominantly observed in presynaptic
active zones of asymmetrical and symmetrical synapses, whereas that for the group
II receptor (mGluR2) was found in preterminal rather than terminal portions of
axons. Target cell-specific segregation of receptors, first reported for mGluR7a
(Shigemoto et al., 1996), was also apparent for the other group III mGluRs, suggesting
that transmitter release is differentially regulated by 2-amino- 4-phosphonobutyrate-sensitive
mGluRs in individual synapses on single axons according to the identity of postsynaptic
neurons.'
acknowledgement: This work was supported by research grants from the Inamori Foundation
and the Ministry of Education, Science, Sports and Culture of Japan. We thank Peter
Somogyi for helpful discussion, David Roberts for technical assistance, and Akira
Uesugi for photographic assistance. We are grateful to Atsu Aiba, David Hampson,
John Roder, and Herman van der Putten for providing us with mGluR1-, mGluR4-, mGluR5-,
and mGluR7-deficient mice, respectively, and to Corrado Corti and Francesco Ferraguti
for sharing rat mGluR8 cDNA and unpublished results.
article_processing_charge: No
article_type: original
author:
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Ayae
full_name: Kinoshita, Ayae
last_name: Kinoshita
- first_name: Eiki
full_name: Wada, Eiki
last_name: Wada
- first_name: Sakashi
full_name: Nomura, Sakashi
last_name: Nomura
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Masahiko
full_name: Takada, Masahiko
last_name: Takada
- first_name: Peter
full_name: Flor, Peter
last_name: Flor
- first_name: Akio
full_name: Neki, Akio
last_name: Neki
- first_name: Takaaki
full_name: Abe, Takaaki
last_name: Abe
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Shigemoto R, Kinoshita A, Wada E, et al. Differential presynaptic localization
of metabotropic glutamate receptor subtypes in the rat hippocampus. Journal
of Neuroscience. 1997;17(19):7503-7522. doi:10.1523/JNEUROSCI.17-19-07503.1997
apa: Shigemoto, R., Kinoshita, A., Wada, E., Nomura, S., Ohishi, H., Takada, M.,
… Mizuno, N. (1997). Differential presynaptic localization of metabotropic glutamate
receptor subtypes in the rat hippocampus. Journal of Neuroscience. Society
for Neuroscience. https://doi.org/10.1523/JNEUROSCI.17-19-07503.1997
chicago: Shigemoto, Ryuichi, Ayae Kinoshita, Eiki Wada, Sakashi Nomura, Hitoshi
Ohishi, Masahiko Takada, Peter Flor, et al. “Differential Presynaptic Localization
of Metabotropic Glutamate Receptor Subtypes in the Rat Hippocampus.” Journal
of Neuroscience. Society for Neuroscience, 1997. https://doi.org/10.1523/JNEUROSCI.17-19-07503.1997.
ieee: R. Shigemoto et al., “Differential presynaptic localization of metabotropic
glutamate receptor subtypes in the rat hippocampus,” Journal of Neuroscience,
vol. 17, no. 19. Society for Neuroscience, pp. 7503–7522, 1997.
ista: Shigemoto R, Kinoshita A, Wada E, Nomura S, Ohishi H, Takada M, Flor P, Neki
A, Abe T, Nakanishi S, Mizuno N. 1997. Differential presynaptic localization of
metabotropic glutamate receptor subtypes in the rat hippocampus. Journal of Neuroscience.
17(19), 7503–7522.
mla: Shigemoto, Ryuichi, et al. “Differential Presynaptic Localization of Metabotropic
Glutamate Receptor Subtypes in the Rat Hippocampus.” Journal of Neuroscience,
vol. 17, no. 19, Society for Neuroscience, 1997, pp. 7503–22, doi:10.1523/JNEUROSCI.17-19-07503.1997.
short: R. Shigemoto, A. Kinoshita, E. Wada, S. Nomura, H. Ohishi, M. Takada, P.
Flor, A. Neki, T. Abe, S. Nakanishi, N. Mizuno, Journal of Neuroscience 17 (1997)
7503–7522.
date_created: 2018-12-11T11:58:30Z
date_published: 1997-10-01T00:00:00Z
date_updated: 2022-08-22T11:32:01Z
day: '01'
doi: 10.1523/JNEUROSCI.17-19-07503.1997
extern: '1'
external_id:
pmid:
- '9295396'
intvolume: ' 17'
issue: '19'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6573434/
month: '10'
oa: 1
oa_version: Published Version
page: 7503 - 7522
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '4317'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Differential presynaptic localization of metabotropic glutamate receptor subtypes
in the rat hippocampus
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 17
year: '1997'
...
---
_id: '2581'
abstract:
- lang: eng
text: It is well known that striatonigral neurons produce substance P (SP); however,
no SP receptor (SPR) has so far been found in the substantia nigra. On the other
hand, a previous study in the rat striatum indicated that SPR was expressed only
in cholinergic or somatostatinergic intrinsic neurons (Kaneko et al. [1993] Brain
Res. 631:297-303). Thus, it was assumed that SP produced by striatenigral neurons
might be released through their intrastriatal axon collaterals to act upon intrinsic
neurons in the striatum. To confirm this assumption, the distribution of axon
collaterals of striatonigral neurons was examined in the striatum of the rat.
The experiments were performed on brain slices by combining retrograde labeling
with tetramethylrhodamine-dextran amine, electrophysiological recording, intracellular
staining with biocytin, and immunocytochemistry for SPR. The distribution of axons
of cholinergic striatal neurons (a group of SP-negative intrinsic striatal neurons)
was also examined. It was observed that 16% of varicosities of intrastriatal axon
collaterals of striatonigral neurons, as well as 6% of axonal varicosities of
cholinergic neurons, were in close apposition to dendrites and cell bodies of
SPB-immunoreactive striatal neurons. Since SPR-immunoreactive striatal neurons
constituted only 2.7% of the total population of striatal neurons (Kaneko et al.
[1993] Brain Res. 631:297-303), it appeared that axonal varicosities of striatonigral
neurons were preferentially apposed to SPR-immunoreactive striatal neurons and
that the varicosities in close apposition to SPR-immunoreactive neurons were derived
more frequently from striatonigral neurons than from cholinergic interneurons.
Confocal laser scanning microscopy indicated that axonal varicosities in close
apposition to SPR-immunoreactive cells showed synaptophysin immunoreactivity,
a marker of synaptic vesicles. In intrastriatal axons of striatonigral neurons,
it was further revealed from electron microscopy that axonal varicosities in close
apposition to SPR- immunoreactive dendrites, at least a part of them, made synapses
of the symmetric type. Striatonigral neurons might release SP preferentially around
cholinergic or somatostatinergic intrinsic neurons to regulate them through SP-SPR
interactions.
acknowledgement: The authors are grateful for the photographic help of Mr.A. Uesugi.
We also express our gratitude for the support ofDrs. Satoru Fukuchi, Ritsu Hayashi,
Sohzaburo Hayashi,Mizuho Katsurada, Hitoshi Kawai, Yutaka Kitani, Toshi-hiko Kuroda,
Keiko Kumagai, Hiroshi Matsubara, HiroshiMatsushima, Chisato Minakuchi, Gonpei Niwa, HajimeOda,
Masahiko Ohbayashi, Sei-ichi Ohbayashi, Hiroyasu Ohtsuka, Shigeo Tamaki, Eizo Watanabe,
Kazuo Yoshino,and Toshiaki Yoshino.
article_processing_charge: No
article_type: original
author:
- first_name: Teffy
full_name: Lee, Teffy
last_name: Lee
- first_name: Takeshi
full_name: Kaneko, Takeshi
last_name: Kaneko
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Sakashi
full_name: Nomura, Sakashi
last_name: Nomura
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Lee T, Kaneko T, Shigemoto R, Nomura S, Mizuno N. Collateral projections from
striatonigral neurons to substance P receptor-expressing intrinsic neurons in
the striatum of the rat. Journal of Comparative Neurology. 1997;388(2):250-264.
doi:10.1002/(SICI)1096-9861(19971117)388:2<250::AID-CNE5>3.0.CO;2-0
apa: Lee, T., Kaneko, T., Shigemoto, R., Nomura, S., & Mizuno, N. (1997). Collateral
projections from striatonigral neurons to substance P receptor-expressing intrinsic
neurons in the striatum of the rat. Journal of Comparative Neurology. Wiley-Blackwell.
https://doi.org/10.1002/(SICI)1096-9861(19971117)388:2<250::AID-CNE5>3.0.CO;2-0
chicago: Lee, Teffy, Takeshi Kaneko, Ryuichi Shigemoto, Sakashi Nomura, and Noboru
Mizuno. “Collateral Projections from Striatonigral Neurons to Substance P Receptor-Expressing
Intrinsic Neurons in the Striatum of the Rat.” Journal of Comparative Neurology.
Wiley-Blackwell, 1997. https://doi.org/10.1002/(SICI)1096-9861(19971117)388:2<250::AID-CNE5>3.0.CO;2-0.
ieee: T. Lee, T. Kaneko, R. Shigemoto, S. Nomura, and N. Mizuno, “Collateral projections
from striatonigral neurons to substance P receptor-expressing intrinsic neurons
in the striatum of the rat,” Journal of Comparative Neurology, vol. 388,
no. 2. Wiley-Blackwell, pp. 250–264, 1997.
ista: Lee T, Kaneko T, Shigemoto R, Nomura S, Mizuno N. 1997. Collateral projections
from striatonigral neurons to substance P receptor-expressing intrinsic neurons
in the striatum of the rat. Journal of Comparative Neurology. 388(2), 250–264.
mla: Lee, Teffy, et al. “Collateral Projections from Striatonigral Neurons to Substance
P Receptor-Expressing Intrinsic Neurons in the Striatum of the Rat.” Journal
of Comparative Neurology, vol. 388, no. 2, Wiley-Blackwell, 1997, pp. 250–64,
doi:10.1002/(SICI)1096-9861(19971117)388:2<250::AID-CNE5>3.0.CO;2-0.
short: T. Lee, T. Kaneko, R. Shigemoto, S. Nomura, N. Mizuno, Journal of Comparative
Neurology 388 (1997) 250–264.
date_created: 2018-12-11T11:58:30Z
date_published: 1997-11-17T00:00:00Z
date_updated: 2022-08-22T10:03:38Z
day: '17'
doi: 10.1002/(SICI)1096-9861(19971117)388:2<250::AID-CNE5>3.0.CO;2-0
extern: '1'
external_id:
pmid:
- '9368840'
intvolume: ' 388'
issue: '2'
language:
- iso: eng
month: '11'
oa_version: None
page: 250 - 264
pmid: 1
publication: Journal of Comparative Neurology
publication_identifier:
issn:
- 0021-9967
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4316'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Collateral projections from striatonigral neurons to substance P receptor-expressing
intrinsic neurons in the striatum of the rat
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 388
year: '1997'
...
---
_id: '2579'
abstract:
- lang: eng
text: The localisation of the neurokinin 3 receptor (NK3r) in the rat gastrointestinal
tract has been studied by using a polyclonal antiserum against the C-terminal
portion (amino acids 388-452) of the rat NK3r. In the oesophagus, immunoreactivity
for the NK3r was found on smooth muscle cells of the muscularis mucosae. NK3r
immunoreactivity was not present on muscle cells of other regions. Nerve cell
bodies immunoreactive for NK3r were seen in the myenteric and submucous plexuses
of the small and large intestine, but not in the stomach or oesophagus. Immunoreactivity
was largely confined to nerve cell surfaces. The reaction product was on the cell
soma and initial parts of axons. Reactivity was not seen on nerve terminals. Immunoreactive
nerve cells had Dogiel Type II morphology. Patterns of co-localisation of NK3r
and immunoreactivity for other markers were examined in the ileum, to provide
a basis from which to deduce the functional identity of NK3r-immunoreactive nerve
cells. Most of the NK3r-immunoreactive nerve cells were also immunoreactive for
the calcium-binding proteins, calretinin and calbindin, and all were immunoreactive
for the NK1 receptor (NK1r). Nerve cells that were immunoreactive for nitric oxide
synthase were not immunoreactive for either NK3r or NK1r. The projections of the
calbindin and calretinin neurons were determined by nerve lesion studies. Their
morphology, projections to the mucosa and other ganglia and immunoreactivity for
the calcium-binding proteins suggest that the NK3r-immunoreactive neurons are
intrinsic sensory neurons.
acknowledgement: This work was supported by grants from the National Health and Medical
Research Council of Australia and the National Science Foundation of the Peoples
Republic of China. Patricia Mann is a holder of a Gastroenterological Society of
Australia Post-Graduate Scholarship.
article_processing_charge: No
article_type: original
author:
- first_name: Patricia
full_name: Mann, Patricia
last_name: Mann
- first_name: Bridget
full_name: Southwell, Bridget
last_name: Southwell
- first_name: Yu
full_name: Ding, Yu
last_name: Ding
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
- first_name: John
full_name: Furness, John
last_name: Furness
citation:
ama: Mann P, Southwell B, Ding Y, Shigemoto R, Mizuno N, Furness J. Localisation
of neurokinin 3 (NK3) receptor immunoreactivity in the rat gastrointestinal tract.
Cell and Tissue Research. 1997;289(1):1-9. doi:10.1007/s004410050846
apa: Mann, P., Southwell, B., Ding, Y., Shigemoto, R., Mizuno, N., & Furness,
J. (1997). Localisation of neurokinin 3 (NK3) receptor immunoreactivity in the
rat gastrointestinal tract. Cell and Tissue Research. Springer. https://doi.org/10.1007/s004410050846
chicago: Mann, Patricia, Bridget Southwell, Yu Ding, Ryuichi Shigemoto, Noboru Mizuno,
and John Furness. “Localisation of Neurokinin 3 (NK3) Receptor Immunoreactivity
in the Rat Gastrointestinal Tract.” Cell and Tissue Research. Springer,
1997. https://doi.org/10.1007/s004410050846.
ieee: P. Mann, B. Southwell, Y. Ding, R. Shigemoto, N. Mizuno, and J. Furness, “Localisation
of neurokinin 3 (NK3) receptor immunoreactivity in the rat gastrointestinal tract,”
Cell and Tissue Research, vol. 289, no. 1. Springer, pp. 1–9, 1997.
ista: Mann P, Southwell B, Ding Y, Shigemoto R, Mizuno N, Furness J. 1997. Localisation
of neurokinin 3 (NK3) receptor immunoreactivity in the rat gastrointestinal tract.
Cell and Tissue Research. 289(1), 1–9.
mla: Mann, Patricia, et al. “Localisation of Neurokinin 3 (NK3) Receptor Immunoreactivity
in the Rat Gastrointestinal Tract.” Cell and Tissue Research, vol. 289,
no. 1, Springer, 1997, pp. 1–9, doi:10.1007/s004410050846.
short: P. Mann, B. Southwell, Y. Ding, R. Shigemoto, N. Mizuno, J. Furness, Cell
and Tissue Research 289 (1997) 1–9.
date_created: 2018-12-11T11:58:29Z
date_published: 1997-06-01T00:00:00Z
date_updated: 2022-08-22T12:19:10Z
day: '01'
doi: 10.1007/s004410050846
extern: '1'
external_id:
pmid:
- '9182595'
intvolume: ' 289'
issue: '1'
language:
- iso: eng
month: '06'
oa_version: None
page: 1 - 9
pmid: 1
publication: Cell and Tissue Research
publication_identifier:
issn:
- 0044-3794
publication_status: published
publisher: Springer
publist_id: '4319'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Localisation of neurokinin 3 (NK3) receptor immunoreactivity in the rat gastrointestinal
tract
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 289
year: '1997'
...
---
_id: '2729'
abstract:
- lang: eng
text: We give the leading order semiclassical asymptotics for the sum of the negative
eigenvalues of the Pauli operator (in dimension two and three) with a strong non-homogeneous
magnetic field. As in [LSY-II] for homogeneous field, this result can be used
to prove that the magnetic Thomas-Fermi theory gives the leading order ground
state energy of large atoms. We develop a new localization scheme well suited
to the anisotropic character of the strong magnetic field. We also use the basic
Lieb-Thirring estimate obtained in our companion paper [ES-I].
acknowledgement: L. E. gratefully acknowledges financial support from the Forschungsinstitut
fur Mathematik, ETH, Zurich, where this work was started. He is also grateful for
the hospitality and support of Aarhus University during his visits. The authors
wish to thank the referee for the careful reading of the manuscript and the many
helpful remarks and suggestions.
article_processing_charge: No
article_type: original
author:
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
- first_name: Jan
full_name: Solovej, Jan
last_name: Solovej
citation:
ama: Erdös L, Solovej J. Semiclassical eigenvalue estimates for the Pauli operator
with strong non-homogeneous magnetic fields, II. Leading order asymptotic estimates.
Communications in Mathematical Physics. 1997;188(3):599-656. doi:10.1007/s002200050181
apa: Erdös, L., & Solovej, J. (1997). Semiclassical eigenvalue estimates for
the Pauli operator with strong non-homogeneous magnetic fields, II. Leading order
asymptotic estimates. Communications in Mathematical Physics. Springer.
https://doi.org/10.1007/s002200050181
chicago: Erdös, László, and Jan Solovej. “Semiclassical Eigenvalue Estimates for
the Pauli Operator with Strong Non-Homogeneous Magnetic Fields, II. Leading Order
Asymptotic Estimates.” Communications in Mathematical Physics. Springer,
1997. https://doi.org/10.1007/s002200050181.
ieee: L. Erdös and J. Solovej, “Semiclassical eigenvalue estimates for the Pauli
operator with strong non-homogeneous magnetic fields, II. Leading order asymptotic
estimates,” Communications in Mathematical Physics, vol. 188, no. 3. Springer,
pp. 599–656, 1997.
ista: Erdös L, Solovej J. 1997. Semiclassical eigenvalue estimates for the Pauli
operator with strong non-homogeneous magnetic fields, II. Leading order asymptotic
estimates. Communications in Mathematical Physics. 188(3), 599–656.
mla: Erdös, László, and Jan Solovej. “Semiclassical Eigenvalue Estimates for the
Pauli Operator with Strong Non-Homogeneous Magnetic Fields, II. Leading Order
Asymptotic Estimates.” Communications in Mathematical Physics, vol. 188,
no. 3, Springer, 1997, pp. 599–656, doi:10.1007/s002200050181.
short: L. Erdös, J. Solovej, Communications in Mathematical Physics 188 (1997) 599–656.
date_created: 2018-12-11T11:59:18Z
date_published: 1997-10-01T00:00:00Z
date_updated: 2022-08-22T09:25:09Z
day: '01'
doi: 10.1007/s002200050181
extern: '1'
intvolume: ' 188'
issue: '3'
language:
- iso: eng
month: '10'
oa_version: None
page: 599 - 656
publication: Communications in Mathematical Physics
publication_identifier:
issn:
- 0010-3616
publication_status: published
publisher: Springer
publist_id: '4164'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Semiclassical eigenvalue estimates for the Pauli operator with strong non-homogeneous
magnetic fields, II. Leading order asymptotic estimates
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 188
year: '1997'
...
---
_id: '2727'
abstract:
- lang: eng
text: Diamagnetism of the magnetic Schrödinger operator and paramagnetism of the
Pauli operator are rigorously proven for nonhomogeneous magnetic fields in the
large field, in the large temperature and in the semiclassical asymptotic regimes.
New counterexamples are presented which show that neither dia-nor paramagnetism
is true in a robust sense (without asymptotics). In particular, we demonstrate
that the recent diamagnetic comparison result by Loss and Thaller [M. Loss and
B. Thaller, Commun. Math. Phys. (submitted)] is essentially the best one can hope
for.
acknowledgement: This work was started in the stimulating environment and with the
financial support of the PCMI Summer School on Probability Theory ~IAS Princeton,
1996!. The author also expresses his gratitude to M. Loss and B. Thaller for explaining
their paper to him.
article_processing_charge: No
article_type: original
author:
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
citation:
ama: Erdös L. Dia- and paramagnetism for nonhomogeneous magnetic fields. Journal
of Mathematical Physics. 1997;38(3):1289-1317. doi:10.1063/1.531909
apa: Erdös, L. (1997). Dia- and paramagnetism for nonhomogeneous magnetic fields.
Journal of Mathematical Physics. American Institute of Physics. https://doi.org/10.1063/1.531909
chicago: Erdös, László. “Dia- and Paramagnetism for Nonhomogeneous Magnetic Fields.”
Journal of Mathematical Physics. American Institute of Physics, 1997. https://doi.org/10.1063/1.531909.
ieee: L. Erdös, “Dia- and paramagnetism for nonhomogeneous magnetic fields,” Journal
of Mathematical Physics, vol. 38, no. 3. American Institute of Physics, pp.
1289–1317, 1997.
ista: Erdös L. 1997. Dia- and paramagnetism for nonhomogeneous magnetic fields.
Journal of Mathematical Physics. 38(3), 1289–1317.
mla: Erdös, László. “Dia- and Paramagnetism for Nonhomogeneous Magnetic Fields.”
Journal of Mathematical Physics, vol. 38, no. 3, American Institute of
Physics, 1997, pp. 1289–317, doi:10.1063/1.531909.
short: L. Erdös, Journal of Mathematical Physics 38 (1997) 1289–1317.
date_created: 2018-12-11T11:59:17Z
date_published: 1997-03-01T00:00:00Z
date_updated: 2022-08-22T09:48:50Z
day: '01'
doi: 10.1063/1.531909
extern: '1'
intvolume: ' 38'
issue: '3'
language:
- iso: eng
month: '03'
oa_version: None
page: 1289 - 1317
publication: Journal of Mathematical Physics
publication_identifier:
issn:
- 0022-2488
publication_status: published
publisher: American Institute of Physics
publist_id: '4165'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Dia- and paramagnetism for nonhomogeneous magnetic fields
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 38
year: '1997'
...
---
_id: '3632'
abstract:
- lang: eng
text: An important but controversial class of hypotheses concerning the evolution
of female preferences for extreme male mating displays involves 'indirect selection.'
Even in the absence of direct fitness effects, preference for males with high
overall fitness can spread via a genetic correlation that develops between preference
alleles and high fitness genotypes. Here we develop a quantitative expression
for the force of indirect selection that (i) applies to any female mating behavior,
(ii) is relatively insensitive to the underlying genetics, and (iii) is based
on measurable quantities. In conjunction with the limited data now available,
it suggests that the evolutionary force generated by indirect selection on preferences
is weak in absolute terms. This finding raises the possibility that direct selection
on preference genes may often be more important than indirect selection, but more
data on the quantities identified by our model and on direct selection are needed
to decide the question.
acknowledgement: We thank J. J. Bull, M. J. Ryan, M. Wade, B. Walsh, G. C. Williams,
and an anonymous reviewer for discussions and suggestions. This research was supported
by National Science Foundation Grant DEB94 – 07969, Biotechnology and Biological
Sciences Research Council Grants GRyHy09928 and GRyJy76057, and a travel grant from
the Burroughs-Wellcome Fund.
article_processing_charge: No
article_type: original
author:
- first_name: Mark
full_name: Kirkpatrick, Mark
last_name: Kirkpatrick
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Kirkpatrick M, Barton NH. The strength of indirect selection on female mating
preferences. PNAS. 1997;94(4):1282-1286. doi:10.1073/pnas.94.4.1282
apa: Kirkpatrick, M., & Barton, N. H. (1997). The strength of indirect selection
on female mating preferences. PNAS. National Academy of Sciences. https://doi.org/10.1073/pnas.94.4.1282
chicago: Kirkpatrick, Mark, and Nicholas H Barton. “The Strength of Indirect Selection
on Female Mating Preferences.” PNAS. National Academy of Sciences, 1997.
https://doi.org/10.1073/pnas.94.4.1282.
ieee: M. Kirkpatrick and N. H. Barton, “The strength of indirect selection on female
mating preferences,” PNAS, vol. 94, no. 4. National Academy of Sciences,
pp. 1282–1286, 1997.
ista: Kirkpatrick M, Barton NH. 1997. The strength of indirect selection on female
mating preferences. PNAS. 94(4), 1282–1286.
mla: Kirkpatrick, Mark, and Nicholas H. Barton. “The Strength of Indirect Selection
on Female Mating Preferences.” PNAS, vol. 94, no. 4, National Academy of
Sciences, 1997, pp. 1282–86, doi:10.1073/pnas.94.4.1282.
short: M. Kirkpatrick, N.H. Barton, PNAS 94 (1997) 1282–1286.
date_created: 2018-12-11T12:04:21Z
date_published: 1997-02-18T00:00:00Z
date_updated: 2022-08-19T09:25:21Z
day: '18'
doi: 10.1073/pnas.94.4.1282
extern: '1'
external_id:
pmid:
- '9037044 '
intvolume: ' 94'
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://europepmc.org/article/med/9037044
month: '02'
oa: 1
oa_version: Published Version
page: 1282 - 1286
pmid: 1
publication: PNAS
publication_identifier:
issn:
- 0027-8424
publication_status: published
publisher: National Academy of Sciences
publist_id: '2751'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The strength of indirect selection on female mating preferences
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 94
year: '1997'
...
---
_id: '3633'
abstract:
- lang: eng
text: 'Gene flow from the center of a species'' range can stymie adaptation at the
periphery and prevent the range from expanding outward. We study this process
using simple models that track both demography and the evolution of a quantitative
trait in a population that is continuously distributed in space. Stabilizing selection
acts on the trait and favors an optimum phenotype that changes linearly across
the habitat. One of three outcomes is possible: the species will become extinct,
expand to fill all of the available habitat, or be confined to a limited range
in which it is significantly adapted to allow population growth. When the environment
changes rapidly in space, increased migration inhibits local adaptation and so
decreases the species'' total population size. Gene flow can cause enough maladaptation
that the peripheral half of a species'' range acts as an demographic sink. The
trait''s genetic variance has little effect on species persistence or the size
of the range when gene flow is sufficiently strong to keep population densities
far below the carrying capacity throughout the range, but it can increase the
range width and population size of an abundant species. Under some conditions,
a small parameter change can dramatically shift the balance between gene flow
and local adaptation, allowing a species with a limited range to suddenly expand
to fill all the available habitat.'
article_processing_charge: No
article_type: original
author:
- first_name: Mark
full_name: Kirkpatrick, Mark
last_name: Kirkpatrick
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Kirkpatrick M, Barton NH. Evolution of a species’ range. American Naturalist.
1997;150(1):1-23. doi:10.1086/286054
apa: Kirkpatrick, M., & Barton, N. H. (1997). Evolution of a species’ range.
American Naturalist. University of Chicago Press. https://doi.org/10.1086/286054
chicago: Kirkpatrick, Mark, and Nicholas H Barton. “Evolution of a Species’ Range.”
American Naturalist. University of Chicago Press, 1997. https://doi.org/10.1086/286054.
ieee: M. Kirkpatrick and N. H. Barton, “Evolution of a species’ range,” American
Naturalist, vol. 150, no. 1. University of Chicago Press, pp. 1–23, 1997.
ista: Kirkpatrick M, Barton NH. 1997. Evolution of a species’ range. American Naturalist.
150(1), 1–23.
mla: Kirkpatrick, Mark, and Nicholas H. Barton. “Evolution of a Species’ Range.”
American Naturalist, vol. 150, no. 1, University of Chicago Press, 1997,
pp. 1–23, doi:10.1086/286054.
short: M. Kirkpatrick, N.H. Barton, American Naturalist 150 (1997) 1–23.
date_created: 2018-12-11T12:04:21Z
date_published: 1997-07-01T00:00:00Z
date_updated: 2022-08-19T08:38:36Z
day: '01'
doi: 10.1086/286054
extern: '1'
external_id:
pmid:
- '18811273'
intvolume: ' 150'
issue: '1'
language:
- iso: eng
month: '07'
oa_version: None
page: 1 - 23
pmid: 1
publication: American Naturalist
publication_identifier:
issn:
- 0003-0147
publication_status: published
publisher: University of Chicago Press
publist_id: '2750'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Evolution of a species' range
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 150
year: '1997'
...
---
_id: '4022'
abstract:
- lang: eng
text: A halving hyperplane of a set S of n points in R(d) contains d affinely independent
points of S so that equally many of the points off the hyperplane lie in each
of the two half-spaces. We prove bounds on the number of halving hyperplanes under
the condition that the ratio of largest over smallest distance between any two
points is at most delta n(1/d), delta some constant. Such a set S is called dense.
In d = 2 dimensions the number of halving lines for a dense set can be as much
as Omega(n log n), and it cannot exceed O (n(5/4)/log* n). The upper bound improves
over the current best bound of O (n(3/2)/log* n) which holds more generally without
any density assumption. In d = 3 dimensions we show that O (n(7/3)) is an upper
bound on the number of halving planes for a dense set, The proof is based on a
metric argument that can be extended to d greater than or equal to 4 dimensions,
where it leads to O (n(d-2/d)) as an upper bound for the number of halving hyperplanes.
acknowledgement: Partially supported by the National Science Foundation, under Grant
ASC-9200301 and the Alan T. Waterman award, Grant CCR-9118874.
article_processing_charge: No
article_type: original
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Pavel
full_name: Valtr, Pavel
last_name: Valtr
- first_name: Emo
full_name: Welzl, Emo
last_name: Welzl
citation:
ama: Edelsbrunner H, Valtr P, Welzl E. Cutting dense point sets in half. Discrete
& Computational Geometry. 1997;17(3):243-255. doi:10.1007/PL00009291
apa: Edelsbrunner, H., Valtr, P., & Welzl, E. (1997). Cutting dense point sets
in half. Discrete & Computational Geometry. Springer. https://doi.org/10.1007/PL00009291
chicago: Edelsbrunner, Herbert, Pavel Valtr, and Emo Welzl. “Cutting Dense Point
Sets in Half.” Discrete & Computational Geometry. Springer, 1997. https://doi.org/10.1007/PL00009291.
ieee: H. Edelsbrunner, P. Valtr, and E. Welzl, “Cutting dense point sets in half,”
Discrete & Computational Geometry, vol. 17, no. 3. Springer, pp. 243–255,
1997.
ista: Edelsbrunner H, Valtr P, Welzl E. 1997. Cutting dense point sets in half.
Discrete & Computational Geometry. 17(3), 243–255.
mla: Edelsbrunner, Herbert, et al. “Cutting Dense Point Sets in Half.” Discrete
& Computational Geometry, vol. 17, no. 3, Springer, 1997, pp. 243–55,
doi:10.1007/PL00009291.
short: H. Edelsbrunner, P. Valtr, E. Welzl, Discrete & Computational Geometry
17 (1997) 243–255.
date_created: 2018-12-11T12:06:29Z
date_published: 1997-04-01T00:00:00Z
date_updated: 2022-08-18T14:08:38Z
day: '01'
doi: 10.1007/PL00009291
extern: '1'
intvolume: ' 17'
issue: '3'
language:
- iso: eng
month: '04'
oa_version: None
page: 243 - 255
publication: Discrete & Computational Geometry
publication_identifier:
issn:
- 0179-5376
publication_status: published
publisher: Springer
publist_id: '2103'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Cutting dense point sets in half
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 17
year: '1997'
...
---
_id: '4021'
abstract:
- lang: eng
text: A homeomorphism from R-2 to itself distorts metric quantities, such as distance
and area. We describe an algorithm that constructs homeomorphisms with prescribed
area distortion. Such homeomorphisms can be used to generate cartograms, which
are geographic maps purposely distorted so their area distributions reflects a
variable different from area, as for example population density. The algorithm
generates the homeomorphism through a sequence of local piecewise linear homeomorphic
changes. Sample results produced by the preliminary implementation of the method
are included.
acknowledgement: 'The authors thank Jack Snoeyink for bringing the cartogram problem
to their attention, and Michael McAllister for providing pointers to the literature
on cartograms. '
article_processing_charge: No
article_type: original
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Roman
full_name: Waupotitsch, Roman
last_name: Waupotitsch
citation:
ama: 'Edelsbrunner H, Waupotitsch R. A combinatorial approach to cartograms. Computational
Geometry: Theory and Applications. 1997;7(5-6):343-360. doi:10.1016/S0925-7721(96)00006-5'
apa: 'Edelsbrunner, H., & Waupotitsch, R. (1997). A combinatorial approach to
cartograms. Computational Geometry: Theory and Applications. Elsevier.
https://doi.org/10.1016/S0925-7721(96)00006-5'
chicago: 'Edelsbrunner, Herbert, and Roman Waupotitsch. “A Combinatorial Approach
to Cartograms.” Computational Geometry: Theory and Applications. Elsevier,
1997. https://doi.org/10.1016/S0925-7721(96)00006-5.'
ieee: 'H. Edelsbrunner and R. Waupotitsch, “A combinatorial approach to cartograms,”
Computational Geometry: Theory and Applications, vol. 7, no. 5–6. Elsevier,
pp. 343–360, 1997.'
ista: 'Edelsbrunner H, Waupotitsch R. 1997. A combinatorial approach to cartograms.
Computational Geometry: Theory and Applications. 7(5–6), 343–360.'
mla: 'Edelsbrunner, Herbert, and Roman Waupotitsch. “A Combinatorial Approach to
Cartograms.” Computational Geometry: Theory and Applications, vol. 7, no.
5–6, Elsevier, 1997, pp. 343–60, doi:10.1016/S0925-7721(96)00006-5.'
short: 'H. Edelsbrunner, R. Waupotitsch, Computational Geometry: Theory and Applications
7 (1997) 343–360.'
date_created: 2018-12-11T12:06:29Z
date_published: 1997-04-01T00:00:00Z
date_updated: 2022-08-19T08:12:03Z
day: '01'
doi: 10.1016/S0925-7721(96)00006-5
extern: '1'
intvolume: ' 7'
issue: 5-6
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/S0925772196000065
month: '04'
oa: 1
oa_version: Published Version
page: 343 - 360
popular_science: '1'
publication: 'Computational Geometry: Theory and Applications'
publication_identifier:
issn:
- 0925-7721
publication_status: published
publisher: Elsevier
publist_id: '2105'
status: public
title: A combinatorial approach to cartograms
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 7
year: '1997'
...
---
_id: '4023'
abstract:
- lang: eng
text: Let B be a finite pseudodisk collection in the plane. By the principle of
inclusion-exclusion, the area or any other measure of the union is [GRAPHICS]
We show the existence of a two-dimensional abstract simplicial complex, X subset
of or equal to 2(B), so the above relation holds even if X is substituted for
2(B). In addition, X can be embedded in R(2) SO its underlying space is homotopy
equivalent to int Boolean OR B, and the frontier of X is isomorphic to the nerve
of the set of boundary contributions.
acknowledgement: Supported by the National Science Foundation, under Grant ASC-9200301
and the Alan T. Waterman Award CCR-9118874.
article_processing_charge: No
article_type: original
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Edgar
full_name: Ramos, Edgar
last_name: Ramos
citation:
ama: Edelsbrunner H, Ramos E. Inclusion-exclusion complexes for pseudodisk collections.
Discrete & Computational Geometry. 1997;17(3):287-306. doi:10.1007/PL00009295
apa: Edelsbrunner, H., & Ramos, E. (1997). Inclusion-exclusion complexes for
pseudodisk collections. Discrete & Computational Geometry. Springer.
https://doi.org/10.1007/PL00009295
chicago: Edelsbrunner, Herbert, and Edgar Ramos. “Inclusion-Exclusion Complexes
for Pseudodisk Collections.” Discrete & Computational Geometry. Springer,
1997. https://doi.org/10.1007/PL00009295.
ieee: H. Edelsbrunner and E. Ramos, “Inclusion-exclusion complexes for pseudodisk
collections,” Discrete & Computational Geometry, vol. 17, no. 3. Springer,
pp. 287–306, 1997.
ista: Edelsbrunner H, Ramos E. 1997. Inclusion-exclusion complexes for pseudodisk
collections. Discrete & Computational Geometry. 17(3), 287–306.
mla: Edelsbrunner, Herbert, and Edgar Ramos. “Inclusion-Exclusion Complexes for
Pseudodisk Collections.” Discrete & Computational Geometry, vol. 17,
no. 3, Springer, 1997, pp. 287–306, doi:10.1007/PL00009295.
short: H. Edelsbrunner, E. Ramos, Discrete & Computational Geometry 17 (1997)
287–306.
date_created: 2018-12-11T12:06:30Z
date_published: 1997-04-01T00:00:00Z
date_updated: 2022-08-18T14:39:39Z
day: '01'
doi: 10.1007/PL00009295
extern: '1'
intvolume: ' 17'
issue: '3'
language:
- iso: eng
month: '04'
oa_version: None
page: 287 - 306
publication: Discrete & Computational Geometry
publication_identifier:
issn:
- 0179-5376
publication_status: published
publisher: Springer
publist_id: '2104'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Inclusion-exclusion complexes for pseudodisk collections
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 17
year: '1997'
...
---
_id: '4287'
abstract:
- lang: eng
text: 'We evaluate Sewall Wright''s three-phase "shifting balance" theory of evolution,
examining both the theoretical issues and the relevant data from nature and the
laboratory. We conclude that while phases I and II of Wright''s theory (the movement
of populations from one "adaptive peak" to another via drift and selection) can
occur under some conditions, genetic drift is often unnecessary for movement between
peaks. Phase III of the shifting balance, in which adaptations spread from particular
populations to the entire species, faces two major theoretical obstacles: (1)
unlike adaptations favored by simple directional selection, adaptations whose
fixation requires some genetic drift are often prevented from spreading by barriers
to gene flow; and (2) it is difficult to assemble complex adaptations whose constituent
parts arise via peak shifts in different demes. Our review of the data from nature
shows that although there is some evidence for individual phases of the shifting
balance process, there are few empirical observations explained better by Wright''s
three-phase mechanism than by simple mass selection. Similarly, artificial selection
experiments fail to show that selection in subdivided populations produces greater
response than does mass selection in large populations. The complexity of the
shifting balance process and the difficulty of establishing that adaptive valleys
have been crossed by genetic drift make it impossible to test Wright''s claim
that adaptations commonly originate by this process. In view of these problems,
it seems unreasonable to consider the shifting balance process as an important
explanation for the evolution of adaptations. '
acknowledgement: 'We thank the following people for discussion and comments on themanuscript:
S.Barrett,J. Bull, B.Charlesworth, D.Charlesworth, P. DeVries, S.Gavrilets, J. H.Gillespie,
R.K.Grosberg, W.G. Hill, A. A.Hoffmann, M.Kirkpatrick, C.H.Langley, R. C.Lewontin,
J.B. Mallet, M. Noor, L.Nunney, H. A. Orr, T. Prout, M.Slatkin, J.Spofford, W.Stephan,
J. B. Walsh, P. Ward, K. Weber, J. Willis, and M.Zwick. We are especially grateful
to D.J. Futuyma and D.Schemskefor their exhaustive criticism of the manuscript.
Needless to say, not all of these reviewers agree with our ideas. This work was
supported by National Institutes of Health grant GM50355 to JAC, National Science
Foundation grant DEB9527808 to MT, and grants from the Darwin Trust of Edinburgh
and the Biotechnology and Biological Sciences Research Council (GRJI76057,GRIHI09928)
to NHB.'
article_processing_charge: No
article_type: original
author:
- first_name: Jerry
full_name: Coyne, Jerry
last_name: Coyne
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Michael
full_name: Turelli, Michael
last_name: Turelli
citation:
ama: 'Coyne J, Barton NH, Turelli M. Perspective: A critique of Sewall Wright’s
shifting balance theory of evolutionight’s shifting balance theory of evolution.
Evolution; International Journal of Organic Evolution. 1997;51(3):643-671.
doi:10.1111/j.1558-5646.1997.tb03650.x'
apa: 'Coyne, J., Barton, N. H., & Turelli, M. (1997). Perspective: A critique
of Sewall Wright’s shifting balance theory of evolutionight’s shifting balance
theory of evolution. Evolution; International Journal of Organic Evolution.
Wiley-Blackwell. https://doi.org/10.1111/j.1558-5646.1997.tb03650.x'
chicago: 'Coyne, Jerry, Nicholas H Barton, and Michael Turelli. “Perspective: A
Critique of Sewall Wright’s Shifting Balance Theory of Evolutionight’s Shifting
Balance Theory of Evolution.” Evolution; International Journal of Organic Evolution.
Wiley-Blackwell, 1997. https://doi.org/10.1111/j.1558-5646.1997.tb03650.x.'
ieee: 'J. Coyne, N. H. Barton, and M. Turelli, “Perspective: A critique of Sewall
Wright’s shifting balance theory of evolutionight’s shifting balance theory of
evolution,” Evolution; International Journal of Organic Evolution, vol.
51, no. 3. Wiley-Blackwell, pp. 643–671, 1997.'
ista: 'Coyne J, Barton NH, Turelli M. 1997. Perspective: A critique of Sewall Wright’s
shifting balance theory of evolutionight’s shifting balance theory of evolution.
Evolution; International Journal of Organic Evolution. 51(3), 643–671.'
mla: 'Coyne, Jerry, et al. “Perspective: A Critique of Sewall Wright’s Shifting
Balance Theory of Evolutionight’s Shifting Balance Theory of Evolution.” Evolution;
International Journal of Organic Evolution, vol. 51, no. 3, Wiley-Blackwell,
1997, pp. 643–71, doi:10.1111/j.1558-5646.1997.tb03650.x.'
short: J. Coyne, N.H. Barton, M. Turelli, Evolution; International Journal of Organic
Evolution 51 (1997) 643–671.
date_created: 2018-12-11T12:08:03Z
date_published: 1997-06-01T00:00:00Z
date_updated: 2022-08-18T09:48:43Z
day: '01'
doi: 10.1111/j.1558-5646.1997.tb03650.x
extern: '1'
external_id:
pmid:
- '28568586'
intvolume: ' 51'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1558-5646.1997.tb03650.x
month: '06'
oa: 1
oa_version: Published Version
page: 643 - 671
pmid: 1
publication: Evolution; International Journal of Organic Evolution
publication_identifier:
issn:
- 0014-3820
publication_status: published
publisher: Wiley-Blackwell
publist_id: '1791'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Perspective: A critique of Sewall Wright''s shifting balance theory of evolutionight''s
shifting balance theory of evolution'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 51
year: '1997'
...
---
_id: '4286'
abstract:
- lang: eng
text: A local barrier to gene flow will delay the spread of an advantageous allele.
Exact calculations for the deterministic case show that an allele that is favorable
when rare is delayed very little even by a strong barrier; its spread is allowed
by a time proportional to log((B/σ)√2S)/S, where B is the barrier strength, σ
the dispersal range, and fitnesses are 1:1 + S:1 + 2S. However, when there is
selection against heterozytes, such that the allele cannot increase from low frequency,
a barrier can cause a much greater delay. If gene flow is reduced below a critical
value, spread is entirely prevented. Stochastic simulations show that with additive
selection, random drift slows down the spread of the allele, below the deterministic
speed of σ√2S. The delay to the advance of an advantageous allele caused by a
strong barrier can be substantially increased by random drift and increases with
B/(2Sρσ2) in a one-dimensional habitat of density ρ. However, with selection against
heterozygotes, drift can facilitate the spread and can free an allele that would
otherwise be trapped indefinitely by a strong barrier. We discuss the implications
of these results for the evolution of chromosome rearrangements.
acknowledgement: We are specially grateful to H. C. HAUFFE for allowing us to present
her unpublished data. B. NURNBERGER, J. B. SEARLE, H. C. HAUFFE, S. BAIRD, L. KRUUK
and two anonymous referees gave constructive comments on the manuscript. The work
was supported by the European Union (Human Capital and Mobility Contract No. RB4050PL922765.
article_processing_charge: No
article_type: original
author:
- first_name: Jaroslav
full_name: Piálek, Jaroslav
last_name: Piálek
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: 'Piálek J, Barton NH. The spread of an advantageous allele across a barrier:
the effects of random drift and selection against heterozygotes. Genetics.
1997;145(2):493-504. doi:10.1093/genetics/145.2.493'
apa: 'Piálek, J., & Barton, N. H. (1997). The spread of an advantageous allele
across a barrier: the effects of random drift and selection against heterozygotes.
Genetics. Genetics Society of America. https://doi.org/10.1093/genetics/145.2.493'
chicago: 'Piálek, Jaroslav, and Nicholas H Barton. “The Spread of an Advantageous
Allele across a Barrier: The Effects of Random Drift and Selection against Heterozygotes.”
Genetics. Genetics Society of America, 1997. https://doi.org/10.1093/genetics/145.2.493.'
ieee: 'J. Piálek and N. H. Barton, “The spread of an advantageous allele across
a barrier: the effects of random drift and selection against heterozygotes,” Genetics,
vol. 145, no. 2. Genetics Society of America, pp. 493–504, 1997.'
ista: 'Piálek J, Barton NH. 1997. The spread of an advantageous allele across a
barrier: the effects of random drift and selection against heterozygotes. Genetics.
145(2), 493–504.'
mla: 'Piálek, Jaroslav, and Nicholas H. Barton. “The Spread of an Advantageous Allele
across a Barrier: The Effects of Random Drift and Selection against Heterozygotes.”
Genetics, vol. 145, no. 2, Genetics Society of America, 1997, pp. 493–504,
doi:10.1093/genetics/145.2.493.'
short: J. Piálek, N.H. Barton, Genetics 145 (1997) 493–504.
date_created: 2018-12-11T12:08:03Z
date_published: 1997-02-01T00:00:00Z
date_updated: 2022-08-18T12:34:37Z
day: '01'
doi: 10.1093/genetics/145.2.493
extern: '1'
external_id:
pmid:
- '9071602'
intvolume: ' 145'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://academic.oup.com/genetics/article/145/2/493/6018085
month: '02'
oa: 1
oa_version: Published Version
page: 493 - 504
pmid: 1
publication: Genetics
publication_identifier:
issn:
- 0016-6731
publication_status: published
publisher: Genetics Society of America
publist_id: '1797'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'The spread of an advantageous allele across a barrier: the effects of random
drift and selection against heterozygotes'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 145
year: '1997'
...
---
_id: '4288'
abstract:
- lang: eng
text: We measured the heterozygous effects on net fitness of a sample of 12 wild-type
third chromosomes in D. melanogaster. Effects on fitness were assessed by competing
the wild-type chromosomes against balancer chromosomes, to prevent the production
of recombinants. The measurements were carried out in the population cage environment
in which the life history had been evolving, in an undisturbed population with
overlapping generations, and replicated measurements were made on each chromosome
to control for confounding effects such as mutation accumulation. We found significant
variation among the wild type chromosomes in their additive genetic effect on
net fitness. The system provides an opportunity to obtain an accurate estimate
of the distribution of heterozygous effects on net fitness, the contribution of
different fitness components including male mating success, and the role of intra-chromosomal
epistasis in fitness variation.
acknowledgement: We thank John Sved for helpful discussions in the planningstages
of the project, Brian Charlesworth, Alexei Kondrashov, Trudy Mackay and Steve Stearns
for commentson the manuscript, SERC, BBSRC, the Darwin Trust andthe Royal Society
for Financial support, and Ms N. Goorneyfor technical assistance
article_processing_charge: No
article_type: original
author:
- first_name: Kevin
full_name: Fowler, Kevin
last_name: Fowler
- first_name: Colin
full_name: Semple, Colin
last_name: Semple
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Linda
full_name: Partridge, Linda
last_name: Partridge
citation:
ama: Fowler K, Semple C, Barton NH, Partridge L. Genetic variation for total fitness
in Drosophila melanogaster. Proceedings of the Royal Society of London Series
B Biological Sciences. 1997;264(1379):191-199. doi:10.1098/rspb.1997.0027
apa: Fowler, K., Semple, C., Barton, N. H., & Partridge, L. (1997). Genetic
variation for total fitness in Drosophila melanogaster. Proceedings of the
Royal Society of London Series B Biological Sciences. The Royal Society. https://doi.org/10.1098/rspb.1997.0027
chicago: Fowler, Kevin, Colin Semple, Nicholas H Barton, and Linda Partridge. “Genetic
Variation for Total Fitness in Drosophila Melanogaster.” Proceedings of the
Royal Society of London Series B Biological Sciences. The Royal Society, 1997.
https://doi.org/10.1098/rspb.1997.0027.
ieee: K. Fowler, C. Semple, N. H. Barton, and L. Partridge, “Genetic variation for
total fitness in Drosophila melanogaster,” Proceedings of the Royal Society
of London Series B Biological Sciences, vol. 264, no. 1379. The Royal Society,
pp. 191–199, 1997.
ista: Fowler K, Semple C, Barton NH, Partridge L. 1997. Genetic variation for total
fitness in Drosophila melanogaster. Proceedings of the Royal Society of London
Series B Biological Sciences. 264(1379), 191–199.
mla: Fowler, Kevin, et al. “Genetic Variation for Total Fitness in Drosophila Melanogaster.”
Proceedings of the Royal Society of London Series B Biological Sciences,
vol. 264, no. 1379, The Royal Society, 1997, pp. 191–99, doi:10.1098/rspb.1997.0027.
short: K. Fowler, C. Semple, N.H. Barton, L. Partridge, Proceedings of the Royal
Society of London Series B Biological Sciences 264 (1997) 191–199.
date_created: 2018-12-11T12:08:03Z
date_published: 1997-02-22T00:00:00Z
date_updated: 2022-08-18T11:31:58Z
day: '22'
doi: 10.1098/rspb.1997.0027
extern: '1'
external_id:
pmid:
- '9061969'
intvolume: ' 264'
issue: '1379'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1688253/
month: '02'
oa: 1
oa_version: Published Version
page: 191 - 199
pmid: 1
publication: Proceedings of the Royal Society of London Series B Biological Sciences
publication_identifier:
issn:
- 0962-8452
publication_status: published
publisher: The Royal Society
publist_id: '1792'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Genetic variation for total fitness in Drosophila melanogaster
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 264
year: '1997'
...
---
_id: '4293'
abstract:
- lang: eng
text: Natural populations differ from the simplest models in ways which can significantly
affect their evolution. Real populations are rarely all of the same size; the
rates of migration into and out of populations vary in space and time; some populations
go extinct, and new ones are established, while all populations fluctuate in size.
Furthermore, the genetic properties of real species are not like those assumed
in simple models. Alleles are exposed to a wide variety of selection mutation
rarely creates novel genotypes with each mutation event, generations overlap,
and environments vary from place to place. Evolution in a metapopulation can be
substantially different from the predictions of single-population models and,
indeed, very different from the simplest models of subdivided species.
article_processing_charge: No
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Michael
full_name: Whitlock, Michael
last_name: Whitlock
citation:
ama: 'Barton NH, Whitlock M. The evolution of metapopulations. In: Hanski I, Gilpin
ME, eds. Metapopulation Biology. Academic Press; 1997:183-210. doi:10.1016/B978-012323445-2/50012-2'
apa: Barton, N. H., & Whitlock, M. (1997). The evolution of metapopulations.
In I. Hanski & M. E. Gilpin (Eds.), Metapopulation Biology (pp. 183–210).
Academic Press. https://doi.org/10.1016/B978-012323445-2/50012-2
chicago: Barton, Nicholas H, and Michael Whitlock. “The Evolution of Metapopulations.”
In Metapopulation Biology, edited by Illka Hanski and Michael E. Gilpin,
183–210. Academic Press, 1997. https://doi.org/10.1016/B978-012323445-2/50012-2.
ieee: N. H. Barton and M. Whitlock, “The evolution of metapopulations,” in Metapopulation
Biology, I. Hanski and M. E. Gilpin, Eds. Academic Press, 1997, pp. 183–210.
ista: 'Barton NH, Whitlock M. 1997.The evolution of metapopulations. In: Metapopulation
Biology. , 183–210.'
mla: Barton, Nicholas H., and Michael Whitlock. “The Evolution of Metapopulations.”
Metapopulation Biology, edited by Illka Hanski and Michael E. Gilpin, Academic
Press, 1997, pp. 183–210, doi:10.1016/B978-012323445-2/50012-2.
short: N.H. Barton, M. Whitlock, in:, I. Hanski, M.E. Gilpin (Eds.), Metapopulation
Biology, Academic Press, 1997, pp. 183–210.
date_created: 2018-12-11T12:08:05Z
date_published: 1997-03-12T00:00:00Z
date_updated: 2022-08-17T12:47:42Z
day: '12'
doi: 10.1016/B978-012323445-2/50012-2
editor:
- first_name: Illka
full_name: Hanski, Illka
last_name: Hanski
- first_name: Michael E.
full_name: Gilpin, Michael E.
last_name: Gilpin
extern: '1'
language:
- iso: eng
month: '03'
oa_version: None
page: 183 - 210
publication: Metapopulation Biology
publication_identifier:
isbn:
- '9780123234452'
publication_status: published
publisher: Academic Press
publist_id: '1782'
quality_controlled: '1'
status: public
title: The evolution of metapopulations
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '1997'
...
---
_id: '4289'
abstract:
- lang: eng
text: A worldwide survey of polymorphic molecular markers shows that the human population
is genetically homogeneous, in close agreement with evidence from quite different
genes and traits.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: 'Barton NH. Population genetics: A new apportionment of human diversity. Current
Biology. 1997;7(12):757-758. doi:10.1016/S0960-9822(06)00397-6'
apa: 'Barton, N. H. (1997). Population genetics: A new apportionment of human diversity.
Current Biology. Cell Press. https://doi.org/10.1016/S0960-9822(06)00397-6'
chicago: 'Barton, Nicholas H. “Population Genetics: A New Apportionment of Human
Diversity.” Current Biology. Cell Press, 1997. https://doi.org/10.1016/S0960-9822(06)00397-6.'
ieee: 'N. H. Barton, “Population genetics: A new apportionment of human diversity,”
Current Biology, vol. 7, no. 12. Cell Press, pp. 757–758, 1997.'
ista: 'Barton NH. 1997. Population genetics: A new apportionment of human diversity.
Current Biology. 7(12), 757–758.'
mla: 'Barton, Nicholas H. “Population Genetics: A New Apportionment of Human Diversity.”
Current Biology, vol. 7, no. 12, Cell Press, 1997, pp. 757–58, doi:10.1016/S0960-9822(06)00397-6.'
short: N.H. Barton, Current Biology 7 (1997) 757–758.
date_created: 2018-12-11T12:08:04Z
date_published: 1997-12-01T00:00:00Z
date_updated: 2022-08-17T13:07:08Z
day: '01'
doi: 10.1016/S0960-9822(06)00397-6
extern: '1'
intvolume: ' 7'
issue: '12'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/S0960982206003976?via%3Dihub
month: '12'
oa: 1
oa_version: Published Version
page: 757 - 758
publication: Current Biology
publication_identifier:
issn:
- 0960-9822
publication_status: published
publisher: Cell Press
publist_id: '1788'
quality_controlled: '1'
status: public
title: 'Population genetics: A new apportionment of human diversity'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 7
year: '1997'
...
---
_id: '4291'
article_processing_charge: No
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: 'Barton NH. The ecological detective: Confronting models with data. Genetical
Research. 1997;70(2):180-181.'
apa: 'Barton, N. H. (1997). The ecological detective: Confronting models with data.
Genetical Research. Cambridge University Press.'
chicago: 'Barton, Nicholas H. “The Ecological Detective: Confronting Models with
Data.” Genetical Research. Cambridge University Press, 1997.'
ieee: 'N. H. Barton, “The ecological detective: Confronting models with data,” Genetical
Research, vol. 70, no. 2. Cambridge University Press, pp. 180–181, 1997.'
ista: 'Barton NH. 1997. The ecological detective: Confronting models with data.
Genetical Research. 70(2), 180–181.'
mla: 'Barton, Nicholas H. “The Ecological Detective: Confronting Models with Data.”
Genetical Research, vol. 70, no. 2, Cambridge University Press, 1997, pp.
180–81.'
short: N.H. Barton, Genetical Research 70 (1997) 180–181.
date_created: 2018-12-11T12:08:04Z
date_published: 1997-10-01T00:00:00Z
date_updated: 2022-08-18T09:36:25Z
day: '01'
extern: '1'
intvolume: ' 70'
issue: '2'
language:
- iso: eng
main_file_link:
- url: https://www.cambridge.org/core/journals/genetics-research/article/ecological-detective-confronting-models-with-data-by-ray-hilborn-and-marc-mangel-princeton-university-press-1997-315xvii-pages-price-3000-cloth-1695-paper-isbn-0-691-03496-6-0-691-03497-4-pbk/AA6FCD668DFFAEF537C2674ECCFC8966
month: '10'
oa_version: None
page: 180 - 181
publication: Genetical Research
publication_identifier:
issn:
- 0016-6723
publication_status: published
publisher: Cambridge University Press
publist_id: '1790'
quality_controlled: '1'
status: public
title: 'The ecological detective: Confronting models with data'
type: review
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 70
year: '1997'
...
---
_id: '4290'
article_processing_charge: No
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Barton NH. Natural hybridization and evolution. Genetical Research.
1997;70(2):178-180.
apa: Barton, N. H. (1997). Natural hybridization and evolution. Genetical Research.
Cambridge University Press.
chicago: Barton, Nicholas H. “Natural Hybridization and Evolution.” Genetical
Research. Cambridge University Press, 1997.
ieee: N. H. Barton, “Natural hybridization and evolution,” Genetical Research,
vol. 70, no. 2. Cambridge University Press, pp. 178–180, 1997.
ista: Barton NH. 1997. Natural hybridization and evolution. Genetical Research.
70(2), 178–180.
mla: Barton, Nicholas H. “Natural Hybridization and Evolution.” Genetical Research,
vol. 70, no. 2, Cambridge University Press, 1997, pp. 178–80.
short: N.H. Barton, Genetical Research 70 (1997) 178–180.
date_created: 2018-12-11T12:08:04Z
date_published: 1997-10-01T00:00:00Z
date_updated: 2022-08-17T14:10:20Z
day: '01'
extern: '1'
intvolume: ' 70'
issue: '2'
language:
- iso: eng
month: '10'
oa_version: None
page: 178 - 180
publication: Genetical Research
publication_identifier:
issn:
- 0016-6723
publication_status: published
publisher: Cambridge University Press
publist_id: '1789'
status: public
title: Natural hybridization and evolution
type: review
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 70
year: '1997'
...
---
_id: '3483'
abstract:
- lang: eng
text: 'The main excitatory pathway of the hippocampal formation is controlled by
a network of morphologically distinct populations of GABAergic interneurons. Here
we describe a novel type of GABAergic interneuron located in the outer molecular
layer (OML) of the rat dentate gyrus with a long- range forward projection from
the dentate gyrus to the subiculum across the hippocampal fissure, OML interneurons
were recorded in hippocampal slices by using the whole-cell patch-clamp configuration.
During recording, cells were filled with biocytin for subsequent light and electron
microscopic analysis. Neurons projecting to the subiculum were distributed throughout
the entire OML. They had round or ovoid somata and a multipolar dendritic morphology.
Two axonal domains could be distinguished: an extensive, tangential distribution
within the OML and a long-range vertical and tangential projection to layer 1
and stratum pyramidale of the subiculum. Symmetric synaptic contacts were established
by these interneurons on dendritic shafts in the OML and subiculum. OML interneurons
were characterized physiologically by short action potential duration and marked
afterhyperpolarization that followed the spike. On sustained current injection,
they generated high- frequency (up to 130 Hz, 34°C) trains of action potentials
with only little adaptation. In situ hybridization and single-call RT-PCR analysis
for GAD67 mRNA confirmed the GABAergic nature of OML interneurons. GABAergic interneurons
in the OML projecting to the subiculum connect the input and output regions of
the hippocampus. Hence, they could mediate long-range feed- forward inhibition
and may participate in an oscillating cross-regional interneuron network that
may synchronize the activity of spatially distributed principal neurons in the
dentate gyrus and the subiculum.'
acknowledgement: This work was supported by the Deutsche Forschungsgemeinschaft (SFB
505/A3 and Leibniz program to M.F., SFB 505/C5 to P.J., and DFG 432/3 to H.M.) We
thank Drs. H. Scharfman, M. Häusser, and I. Vida for critically reading an earlier
version of this manuscript. We are also grateful to B. Joch, S. Nestel, M. Winter,
and U. Amtmann for excellent technical assistance.
article_processing_charge: No
article_type: original
author:
- first_name: Katya
full_name: Ceranik, Katya
last_name: Ceranik
- first_name: Roland
full_name: Bender, Roland
last_name: Bender
- first_name: Jörg
full_name: Geiger, Jörg
last_name: Geiger
- first_name: Hannah
full_name: Monyer, Hannah
last_name: Monyer
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Michael
full_name: Frotscher, Michael
last_name: Frotscher
- first_name: Joachim
full_name: Lubke, Joachim
last_name: Lubke
citation:
ama: Ceranik K, Bender R, Geiger J, et al. A novel type of GABAergic interneuron
connecting the input and the output regions of the hippocampus. Journal of
Neuroscience. 1997;17(14):5380-5394. doi:10.1523/JNEUROSCI.17-14-05380.1997
apa: Ceranik, K., Bender, R., Geiger, J., Monyer, H., Jonas, P. M., Frotscher, M.,
& Lubke, J. (1997). A novel type of GABAergic interneuron connecting the input
and the output regions of the hippocampus. Journal of Neuroscience. Society
for Neuroscience. https://doi.org/10.1523/JNEUROSCI.17-14-05380.1997
chicago: Ceranik, Katya, Roland Bender, Jörg Geiger, Hannah Monyer, Peter M Jonas,
Michael Frotscher, and Joachim Lubke. “A Novel Type of GABAergic Interneuron Connecting
the Input and the Output Regions of the Hippocampus.” Journal of Neuroscience.
Society for Neuroscience, 1997. https://doi.org/10.1523/JNEUROSCI.17-14-05380.1997.
ieee: K. Ceranik et al., “A novel type of GABAergic interneuron connecting
the input and the output regions of the hippocampus.,” Journal of Neuroscience,
vol. 17, no. 14. Society for Neuroscience, pp. 5380–5394, 1997.
ista: Ceranik K, Bender R, Geiger J, Monyer H, Jonas PM, Frotscher M, Lubke J. 1997.
A novel type of GABAergic interneuron connecting the input and the output regions
of the hippocampus. Journal of Neuroscience. 17(14), 5380–5394.
mla: Ceranik, Katya, et al. “A Novel Type of GABAergic Interneuron Connecting the
Input and the Output Regions of the Hippocampus.” Journal of Neuroscience,
vol. 17, no. 14, Society for Neuroscience, 1997, pp. 5380–94, doi:10.1523/JNEUROSCI.17-14-05380.1997.
short: K. Ceranik, R. Bender, J. Geiger, H. Monyer, P.M. Jonas, M. Frotscher, J.
Lubke, Journal of Neuroscience 17 (1997) 5380–5394.
date_created: 2018-12-11T12:03:34Z
date_published: 1997-07-15T00:00:00Z
date_updated: 2022-08-22T08:18:54Z
day: '15'
doi: 10.1523/JNEUROSCI.17-14-05380.1997
extern: '1'
external_id:
pmid:
- '9204922'
intvolume: ' 17'
issue: '14'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6793821/
month: '07'
oa: 1
oa_version: Published Version
page: 5380 - 5394
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2904'
quality_controlled: '1'
scopus_import: '1'
status: public
title: A novel type of GABAergic interneuron connecting the input and the output regions
of the hippocampus.
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 17
year: '1997'
...
---
_id: '3485'
abstract:
- lang: eng
text: 1. GABAergic interneurones differ from glutamatergic principal neurones in
their ability to discharge high-frequency trains of action potentials without
adaptation. To examine whether Na+ channel gating contributed to these differences,
Na+ currents were recorded in nucleated patches from interneurones (dentate gyrus
basket cells, BCs) and principal neurones (CA1 pyramidal cells, PCs) of rat hippocampal
slices. 2. The voltage dependence of Na+ channel activation in BCs and PCs was
similar. The slope factors of the activation curves, fitted with Boltzmann functions
raised to the third power, were 11.5 and 11.8 mV, and the mid-point potentials
were -25.1 and -23.9 mV, respectively. 3. Whereas the time course of Na+ channel
activation (-30 to +40 mV) was similar, the deactivation kinetics (-100 to -40
mV) were faster in BCs than in PCs (tail current decay time constants, 0.13 and
0.20 ms, respectively, at -40 mV). 4. Na+ channels in BCs and PCs differed in
the voltage dependence of inactivation. The slope factors of the steady-state
inactivation curves fitted with Boltzmann functions were 6.7 and 10.7 mV, and
the mid-point potentials were -58.3 and -62.9 mV, respectively. 5. The onset of
Na+ channel inactivation at -55 mV was slower in BC's than in PCs; the inactivation
time constants were 18.6 and 9.3 ms, respectively. At more positive potentials
the differences in inactivation onset were smaller. 6. The time course of recovery
of Na+ channels from inactivation induced by a 30 ms pulse was fast and mono-exponential
(τ = 2.0 ms at -120 mV) in BCs, whereas it was slower and biexponential in PCs
(τ1 = 2.0 ms and τ2 = 133 ms; amplitude contribution of the slow component, 15%).
7. We conclude that Na+ channels of BCs and PCs differ in gating properties that
contribute to the characteristic action potential patterns of the two types of
neurones.
acknowledgement: We thank Drs J. Bischofberger and J. R. P. Geiger for critically
reading the manuscript, Mrs B. Plessow-Freudenberg and K. Zipfel for technical assistance,
and Mrs B. Hillers for typing. This work was supported by the German Israeli Foundation
grant I 0352–073.01/94 to P. J.
article_processing_charge: No
article_type: original
author:
- first_name: Marco
full_name: Martina, Marco
last_name: Martina
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Martina M, Jonas PM. Functional differences in Na+ channel gating between fast-spiking
interneurones and principal neurones in rat hippocampus. Journal of Physiology.
1997;505(3):593-603. doi:10.1111/j.1469-7793.1997.593ba.x
apa: Martina, M., & Jonas, P. M. (1997). Functional differences in Na+ channel
gating between fast-spiking interneurones and principal neurones in rat hippocampus.
Journal of Physiology. Wiley-Blackwell. https://doi.org/10.1111/j.1469-7793.1997.593ba.x
chicago: Martina, Marco, and Peter M Jonas. “Functional Differences in Na+ Channel
Gating between Fast-Spiking Interneurones and Principal Neurones in Rat Hippocampus.”
Journal of Physiology. Wiley-Blackwell, 1997. https://doi.org/10.1111/j.1469-7793.1997.593ba.x.
ieee: M. Martina and P. M. Jonas, “Functional differences in Na+ channel gating
between fast-spiking interneurones and principal neurones in rat hippocampus,”
Journal of Physiology, vol. 505, no. 3. Wiley-Blackwell, pp. 593–603, 1997.
ista: Martina M, Jonas PM. 1997. Functional differences in Na+ channel gating between
fast-spiking interneurones and principal neurones in rat hippocampus. Journal
of Physiology. 505(3), 593–603.
mla: Martina, Marco, and Peter M. Jonas. “Functional Differences in Na+ Channel
Gating between Fast-Spiking Interneurones and Principal Neurones in Rat Hippocampus.”
Journal of Physiology, vol. 505, no. 3, Wiley-Blackwell, 1997, pp. 593–603,
doi:10.1111/j.1469-7793.1997.593ba.x.
short: M. Martina, P.M. Jonas, Journal of Physiology 505 (1997) 593–603.
date_created: 2018-12-11T12:03:34Z
date_published: 1997-12-15T00:00:00Z
date_updated: 2022-08-22T08:25:26Z
day: '15'
doi: 10.1111/j.1469-7793.1997.593ba.x
extern: '1'
external_id:
pmid:
- '9457638'
intvolume: ' 505'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1160038/
month: '12'
oa: 1
oa_version: Published Version
page: 593 - 603
pmid: 1
publication: Journal of Physiology
publication_identifier:
issn:
- 0022-3751
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2902'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Functional differences in Na+ channel gating between fast-spiking interneurones
and principal neurones in rat hippocampus
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 505
year: '1997'
...
---
_id: '3482'
abstract:
- lang: eng
text: AMPA- and NMDA-type glutamate receptors (AMPARs and NMDARs) mediate excitatory
synoptic transmission in the basal ganglia and may contribute to excitotoxic injury.
We investigated the functional properties of AMPARs and NMDARs expressed by six
main types of basal ganglia neurons in acute rat brain slices (principal neurons
and cholinergic interneurons of striatum, GABAergic and dopaminergic neurons of
substantia nigra, globus pallidus neurons, and subthalamic nucleus neurons) using
fast application of glutamate to nucleated and outside-out membrane patches, AMPARs
in different types of basal ganglia neurons were functionally distinct. Those
expressed in striatal principal neurons exhibited the slowest gating (desensitization
time constant τ = 11.5 msec, 1 mM glutamate, 22°C), whereas those in striatal
cholinergic interneurons showed the fastest gating (desensitization time constant
τ = 3.6 msec). The lowest Ca2+ permeability of AMPARs was observed in nigral dopaminergic
neurons (P(CA)/P(NA) = 0.10), whereas the highest Ca2+ permeability was found
in subthalamic nucleus neurons (P(Ca)/P(Na) = 1.17). NMDARs of different types
of basal ganglia neurons were less variable in their functional properties; those
expressed in nigral dopaminergic neurons exhibited the slowest gating (deactivation
time constant of predominant fast component τ1 150 msec, 100 μM glutamate), and
those of globus pallidus neurons showed the fastest gating (τ1 = 67 msec). The
Mg2+ block of NMDARs was similar; the average chord conductance ratio g(+60mv)/g(+40mV)
was 0.18-0.22 in 100 μM external Mg2+. Hence, AMPARs expressed in different types
of basal ganglia neurons are markedly diverse, whereas NMDARs are less variable
in functional properties that are relevant for excitatory synoptic transmission
and neuronal vulnerability.
acknowledgement: "This work was supported by Deutsche Forschungsgemeinschaft Grant
BE1859 to T.B. and SFB505/C5 to P.J. We thank Mrs. B. Plessow-Freudenberg for help
with the immunocytochemistry, Dr. M. Ha¨usser for advice concerning the \r\n reparation
of midbrain slices, and Drs. J. Bischofberger, G. B. Landwehrmeyer, and M. Martina
for critically reading this manuscript."
article_processing_charge: No
article_type: original
author:
- first_name: Thomas
full_name: Götz, Thomas
last_name: Götz
- first_name: Udo
full_name: Kraushaar, Udo
last_name: Kraushaar
- first_name: Jörg
full_name: Geiger, Jörg
last_name: Geiger
- first_name: Joachim
full_name: Lubke, Joachim
last_name: Lubke
- first_name: Thomas
full_name: Berger, Thomas
last_name: Berger
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Götz T, Kraushaar U, Geiger J, Lubke J, Berger T, Jonas PM. Functional properties
of AMPA and NMDA receptors expressed in identified types of basal ganglia neurons.
Journal of Neuroscience. 1997;17(1):204-215. doi:10.1523/JNEUROSCI.17-01-00204.1997
apa: Götz, T., Kraushaar, U., Geiger, J., Lubke, J., Berger, T., & Jonas, P.
M. (1997). Functional properties of AMPA and NMDA receptors expressed in identified
types of basal ganglia neurons. Journal of Neuroscience. Society for Neuroscience.
https://doi.org/10.1523/JNEUROSCI.17-01-00204.1997
chicago: Götz, Thomas, Udo Kraushaar, Jörg Geiger, Joachim Lubke, Thomas Berger,
and Peter M Jonas. “Functional Properties of AMPA and NMDA Receptors Expressed
in Identified Types of Basal Ganglia Neurons.” Journal of Neuroscience.
Society for Neuroscience, 1997. https://doi.org/10.1523/JNEUROSCI.17-01-00204.1997.
ieee: T. Götz, U. Kraushaar, J. Geiger, J. Lubke, T. Berger, and P. M. Jonas, “Functional
properties of AMPA and NMDA receptors expressed in identified types of basal ganglia
neurons,” Journal of Neuroscience, vol. 17, no. 1. Society for Neuroscience,
pp. 204–215, 1997.
ista: Götz T, Kraushaar U, Geiger J, Lubke J, Berger T, Jonas PM. 1997. Functional
properties of AMPA and NMDA receptors expressed in identified types of basal ganglia
neurons. Journal of Neuroscience. 17(1), 204–215.
mla: Götz, Thomas, et al. “Functional Properties of AMPA and NMDA Receptors Expressed
in Identified Types of Basal Ganglia Neurons.” Journal of Neuroscience,
vol. 17, no. 1, Society for Neuroscience, 1997, pp. 204–15, doi:10.1523/JNEUROSCI.17-01-00204.1997.
short: T. Götz, U. Kraushaar, J. Geiger, J. Lubke, T. Berger, P.M. Jonas, Journal
of Neuroscience 17 (1997) 204–215.
date_created: 2018-12-11T12:03:34Z
date_published: 1997-01-01T00:00:00Z
date_updated: 2022-08-22T08:48:45Z
day: '01'
doi: 10.1523/JNEUROSCI.17-01-00204.1997
extern: '1'
external_id:
pmid:
- '8987749'
intvolume: ' 17'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6793708/
month: '01'
oa: 1
oa_version: Published Version
page: 204 - 215
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2905'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Functional properties of AMPA and NMDA receptors expressed in identified types
of basal ganglia neurons
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 17
year: '1997'
...
---
_id: '3486'
abstract:
- lang: eng
text: 1. Dendritic patch-clamp recordings were obtained from mitral cells in rat
olfactory bulb slices, up to 350 μm from the soma. Simultaneous dendritic and
somatic whole-cell recordings indicated that action potentials (APs) evoked by
somatic or dendritic current injection were initiated near the soma. Both the
large amplitude (100.7 ± 1.1 mV) and the short duration (1.38 ± 0.07 ms) of the
AP were maintained as the AP propagated back into the primary mitral cell dendrites.
2. Outside-out patches isolated from mitral cell dendrites contained voltage-gated
Na+ channels (peak conductance density, 90 pS μm-2 at -10 mV). When an AP was
used as a somatic voltage-clamp command in the presence of 1 μM tetrodotoxin (TTX),
the amplitude of the dendritic potential was attenuated to 48 ± 14 mV. This shows
that dendritic Na+ channels support the active back-propagation of APs. 3. Dendritic
patches contained voltage-gated K+ channels with high density (conductance density,
513 pS μm-2 at 30 mV. Dendritic K+ currents were reduced to 35% by 1 mM external
tetraethylammonium chloride (TEACl). When an AP was used as a somatic voltage
clamp command in the presence of TEACl, the dendritic potential was markedly prolonged.
This indicates that dendritic K+ channels mediate the fast repolarization of dendritic
APs. 4. We conclude that voltage gated Na+ and K+ channels support dendritic APs
with large amplitudes and short durations that may trigger fast transmitter release
at dendrodendritic synapses in the olfactory bulb.
acknowledgement: We thank Drs J. R. P. Geiger, M. Martina, and D. Schild for critically
reading the manuscript, and Mrs B. Plessow-Freudenberg for technical assistance.
This work was supported by DFG grant BI 642/1-1 and German Israeli Foundation grant
I 0352-073.01/94.
article_processing_charge: No
article_type: original
author:
- first_name: Joseph
full_name: Bischofberger, Joseph
last_name: Bischofberger
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Bischofberger J, Jonas PM. Action potential propagation into the presynaptic
dendrites of rat mitral cells. Journal of Physiology. 1997;504(Pt 2):359-365.
doi:10.1111/j.1469-7793.1997.359be.x
apa: Bischofberger, J., & Jonas, P. M. (1997). Action potential propagation
into the presynaptic dendrites of rat mitral cells. Journal of Physiology.
Wiley-Blackwell. https://doi.org/10.1111/j.1469-7793.1997.359be.x
chicago: Bischofberger, Joseph, and Peter M Jonas. “Action Potential Propagation
into the Presynaptic Dendrites of Rat Mitral Cells.” Journal of Physiology.
Wiley-Blackwell, 1997. https://doi.org/10.1111/j.1469-7793.1997.359be.x.
ieee: J. Bischofberger and P. M. Jonas, “Action potential propagation into the presynaptic
dendrites of rat mitral cells,” Journal of Physiology, vol. 504, no. Pt
2. Wiley-Blackwell, pp. 359–365, 1997.
ista: Bischofberger J, Jonas PM. 1997. Action potential propagation into the presynaptic
dendrites of rat mitral cells. Journal of Physiology. 504(Pt 2), 359–365.
mla: Bischofberger, Joseph, and Peter M. Jonas. “Action Potential Propagation into
the Presynaptic Dendrites of Rat Mitral Cells.” Journal of Physiology,
vol. 504, no. Pt 2, Wiley-Blackwell, 1997, pp. 359–65, doi:10.1111/j.1469-7793.1997.359be.x.
short: J. Bischofberger, P.M. Jonas, Journal of Physiology 504 (1997) 359–365.
date_created: 2018-12-11T12:03:35Z
date_published: 1997-10-15T00:00:00Z
date_updated: 2022-08-19T12:02:21Z
day: '15'
doi: 10.1111/j.1469-7793.1997.359be.x
extern: '1'
external_id:
pmid:
- '9365910'
intvolume: ' 504'
issue: Pt 2
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1159916/
month: '10'
oa: 1
oa_version: Published Version
page: 359 - 365
pmid: 1
publication: Journal of Physiology
publication_identifier:
issn:
- 0022-3751
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2901'
quality_controlled: '1'
status: public
title: Action potential propagation into the presynaptic dendrites of rat mitral cells
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 504
year: '1997'
...
---
_id: '3484'
abstract:
- lang: eng
text: Glutamatergic transmission at a principal neuroninterneuron synapse was investigated
by dual whole-cell patch-clamp recording in rat hippocampal slices combined with
morphological analysis. Evoked EPSPs with rapid time course (half duration ≃ 4
ms; 34°C) were generated at multiple synaptic contacts established on the interneuron
dendrites close to the soma. The underlying postsynaptic conductance change showed
a submillisecond rise and decay, due to the precise timing of glutamate release
and the rapid deactivation of the postsynaptic AMPA receptors. Simulations based
on a compartmental model of the interneuron indicated that the rapid postsynaptic
conductance change determines the shape and the somatodendritic integration of
EPSPs, thus enabling interneurons to detect synchronous principal neuron activity.
acknowledgement: We thank Drs. J. Bischofberger, M. Ha¨usser, and I. Vida for critically
T.F. reading the manuscript; S. Nestel, B. Joch, M. Winter, B. Freudenberg, and
K. Zipfel for excellent technical assistance; and B. Hillers Hestrin, S. for typing.
Supported by the DFG (SFB 505/C5 to P. J. and Leibniz program to M. F.)
article_processing_charge: No
article_type: original
author:
- first_name: Jörg
full_name: Geiger, Jörg
last_name: Geiger
- first_name: Joachim
full_name: Lubke, Joachim
last_name: Lubke
- first_name: Arnd
full_name: Roth, Arnd
last_name: Roth
- first_name: Michael
full_name: Frotscher, Michael
last_name: Frotscher
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Geiger J, Lubke J, Roth A, Frotscher M, Jonas PM. Submillisecond AMPA receptor-mediated
signaling at a principal neuron-interneuron synapse. Neuron. 1997;18(6):1009-1023.
doi:10.1016/S0896-6273(00)80339-6
apa: Geiger, J., Lubke, J., Roth, A., Frotscher, M., & Jonas, P. M. (1997).
Submillisecond AMPA receptor-mediated signaling at a principal neuron-interneuron
synapse. Neuron. Elsevier. https://doi.org/10.1016/S0896-6273(00)80339-6
chicago: Geiger, Jörg, Joachim Lubke, Arnd Roth, Michael Frotscher, and Peter M
Jonas. “Submillisecond AMPA Receptor-Mediated Signaling at a Principal Neuron-Interneuron
Synapse.” Neuron. Elsevier, 1997. https://doi.org/10.1016/S0896-6273(00)80339-6.
ieee: J. Geiger, J. Lubke, A. Roth, M. Frotscher, and P. M. Jonas, “Submillisecond
AMPA receptor-mediated signaling at a principal neuron-interneuron synapse,” Neuron,
vol. 18, no. 6. Elsevier, pp. 1009–1023, 1997.
ista: Geiger J, Lubke J, Roth A, Frotscher M, Jonas PM. 1997. Submillisecond AMPA
receptor-mediated signaling at a principal neuron-interneuron synapse. Neuron.
18(6), 1009–1023.
mla: Geiger, Jörg, et al. “Submillisecond AMPA Receptor-Mediated Signaling at a
Principal Neuron-Interneuron Synapse.” Neuron, vol. 18, no. 6, Elsevier,
1997, pp. 1009–23, doi:10.1016/S0896-6273(00)80339-6.
short: J. Geiger, J. Lubke, A. Roth, M. Frotscher, P.M. Jonas, Neuron 18 (1997)
1009–1023.
date_created: 2018-12-11T12:03:34Z
date_published: 1997-06-01T00:00:00Z
date_updated: 2022-08-22T08:41:54Z
day: '01'
doi: 10.1016/S0896-6273(00)80339-6
extern: '1'
external_id:
pmid:
- '9208867 '
intvolume: ' 18'
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/S0896627300803396?via%3Dihub
month: '06'
oa: 1
oa_version: None
page: 1009 - 1023
pmid: 1
publication: Neuron
publication_identifier:
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
publist_id: '2903'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Submillisecond AMPA receptor-mediated signaling at a principal neuron-interneuron
synapse
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 18
year: '1997'
...
---
_id: '3541'
abstract:
- lang: eng
text: 'The contribution of the various hippocampal regions to the maintenance of
epileptic activity, induced by stimulation of the perforant path or commissural
system, was examined in the awake rat. Combination of multiple-site recordings
with silicon probes, current source density analysis and unit recordings allowed
for a high spatial resolution of the field events. Following perforant path stimulation,
seizures began in the dentate gyrus, followed by events in the CA3-CA1 regions.
After commissural stimulation, rhythmic bursts in the CA3-CA1 circuitry preceded
the activation of the dentate gyrus. Correlation of events in the different subregions
indicated that the sustained rhythmic afterdischarge (2-6 Hz) could not be explained
by a cycle-by-cycle excitation of principal cell populations in the hippocampal-entorhinal
loop. The primary afterdischarge always terminated in the CA1 region, followed
by the dentate gyrus, CA3 region and the entorhinal cortex. The duration and pattern
of the hippocampal afterdischarge was essentially unaffected by removal of the
entorhinal cortex. The emergence of large population spike bursts coincided with
a decreased discharge of interneurons in both CAI and hilar regions. The majority
of hilar interneurons displayed a strong amplitude decrement prior to the onset
of population spike phase of the afterdischarge. These findings suggest that (i)
afterdischarges can independently arise in the CA3-CA1 and entorhinal-dentate
gyrus circuitries, (ii) reverberation of excitation in the hippocampal-entorhinal
loop is not critical for the maintenance of afterdischarges and (iii) decreased
activity of the interneuronal network may release population bursting of principal
cells. '
acknowledgement: We thank K. Wise and J. Hetke for providing us the silicon probes,
J. J. Chrobak, S. L-W. Leung, G. G. Somjen and R. D. Traub for their comments on
the manuscript. This work was supported by NINDS (NS34994; 1P41RR09754; NS33310)
and the Whitehall Foundation. M. Penttonen was a visiting scholar at Rutgers University,
supported by the Finnish Academy of Sciences and the A. I. Virtanen Institute.
article_processing_charge: No
article_type: original
author:
- first_name: Anatol
full_name: Bragin, Anatol
last_name: Bragin
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Markku
full_name: Penttonen, Markku
last_name: Penttonen
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: 'Bragin A, Csicsvari JL, Penttonen M, Buzsáki G. Epileptic afterdischarge in
the hippocampal-entorhinal system: Current source density and unit studies. Neuroscience.
1997;76(4):1187-1203. doi:10.1016/S0306-4522(96)00446-0'
apa: 'Bragin, A., Csicsvari, J. L., Penttonen, M., & Buzsáki, G. (1997). Epileptic
afterdischarge in the hippocampal-entorhinal system: Current source density and
unit studies. Neuroscience. Elsevier. https://doi.org/10.1016/S0306-4522(96)00446-0'
chicago: 'Bragin, Anatol, Jozsef L Csicsvari, Markku Penttonen, and György Buzsáki.
“Epileptic Afterdischarge in the Hippocampal-Entorhinal System: Current Source
Density and Unit Studies.” Neuroscience. Elsevier, 1997. https://doi.org/10.1016/S0306-4522(96)00446-0.'
ieee: 'A. Bragin, J. L. Csicsvari, M. Penttonen, and G. Buzsáki, “Epileptic afterdischarge
in the hippocampal-entorhinal system: Current source density and unit studies,”
Neuroscience, vol. 76, no. 4. Elsevier, pp. 1187–1203, 1997.'
ista: 'Bragin A, Csicsvari JL, Penttonen M, Buzsáki G. 1997. Epileptic afterdischarge
in the hippocampal-entorhinal system: Current source density and unit studies.
Neuroscience. 76(4), 1187–1203.'
mla: 'Bragin, Anatol, et al. “Epileptic Afterdischarge in the Hippocampal-Entorhinal
System: Current Source Density and Unit Studies.” Neuroscience, vol. 76,
no. 4, Elsevier, 1997, pp. 1187–203, doi:10.1016/S0306-4522(96)00446-0.'
short: A. Bragin, J.L. Csicsvari, M. Penttonen, G. Buzsáki, Neuroscience 76 (1997)
1187–1203.
date_created: 2018-12-11T12:03:52Z
date_published: 1997-01-15T00:00:00Z
date_updated: 2022-08-19T11:53:06Z
day: '15'
doi: 10.1016/S0306-4522(96)00446-0
extern: '1'
external_id:
pmid:
- '9027878'
intvolume: ' 76'
issue: '4'
language:
- iso: eng
month: '01'
oa_version: None
page: 1187 - 1203
pmid: 1
publication: Neuroscience
publication_identifier:
issn:
- 0306-4522
publication_status: published
publisher: Elsevier
publist_id: '2844'
quality_controlled: '1'
status: public
title: 'Epileptic afterdischarge in the hippocampal-entorhinal system: Current source
density and unit studies'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 76
year: '1997'
...
---
_id: '3630'
abstract:
- lang: eng
text: This paper derives the long-term effective size, Ne, for a general model of
population subdivision, allowing for differential deme fitness, variable emigration
and immigration rates, extinction, colonization, and correlations across generations
in these processes. We show that various long-term measures of Ne are equivalent.
The effective size of a metapopulation can be expressed in a variety of ways.
At a demographic equilibrium, Ne can be derived from the demography by combining
information about the ultimate contribution of each deme to the future genetic
make-up of the population and Wright's FST's. The effective size is given by Ne
= 1/(1 + var (upsilon) ((1 - FST)/Nin), where n is the number of demes, theta
i is the eventual contribution of individuals in deme i to the whole population
(scaled such that sigma theta i = n), and < > denotes an average weighted
by theta i. This formula is applied to a catastrophic extinction model (where
sites are either empty or at carrying capacity) and to a metapopulation model
with explicit dynamics, where extinction is caused by demographic stochasticity
and by chaos. Contrary to the expectation from the standard island model, the
usual effect of population subdivision is to decrease the effective size relative
to a panmictic population living on the same resource.
acknowledgement: This paper has benefited greatly from the kind efforts oF ARMANDO
CABALLERO, PETER KEIGHTLEY, BEATE NÜRNBERCER and SALLY OTTO in reading and discussing
the manuscript. We also thank MONTY SLATKIN and three anonymous reviewers for their
helpful comments. One of these reviewers in particular greatly improved this paper.
The work reported here was supported by a grant from the Science and Engineering
Research Council (U.R) and the Darwin Trust of Edinburgh, as well as by the Natural
Sciences and Engineering Research Council (Canada).
article_processing_charge: No
article_type: original
author:
- first_name: Michael
full_name: Whitlock, Michael
last_name: Whitlock
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Whitlock M, Barton NH. The effective size of a subdivided population. Genetics.
1997;146(1):427-441. doi:10.1093/genetics/146.1.427
apa: Whitlock, M., & Barton, N. H. (1997). The effective size of a subdivided
population. Genetics. Genetics Society of America. https://doi.org/10.1093/genetics/146.1.427
chicago: Whitlock, Michael, and Nicholas H Barton. “The Effective Size of a Subdivided
Population.” Genetics. Genetics Society of America, 1997. https://doi.org/10.1093/genetics/146.1.427.
ieee: M. Whitlock and N. H. Barton, “The effective size of a subdivided population,”
Genetics, vol. 146, no. 1. Genetics Society of America, pp. 427–441, 1997.
ista: Whitlock M, Barton NH. 1997. The effective size of a subdivided population.
Genetics. 146(1), 427–441.
mla: Whitlock, Michael, and Nicholas H. Barton. “The Effective Size of a Subdivided
Population.” Genetics, vol. 146, no. 1, Genetics Society of America, 1997,
pp. 427–41, doi:10.1093/genetics/146.1.427.
short: M. Whitlock, N.H. Barton, Genetics 146 (1997) 427–441.
date_created: 2018-12-11T12:04:20Z
date_published: 1997-05-01T00:00:00Z
date_updated: 2022-08-19T10:01:10Z
day: '01'
doi: 10.1093/genetics/146.1.427
extern: '1'
external_id:
pmid:
- '9136031 '
intvolume: ' 146'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://academic.oup.com/genetics/article/146/1/427/6053913
month: '05'
oa: 1
oa_version: Published Version
page: 427 - 441
pmid: 1
publication: Genetics
publication_identifier:
issn:
- 0016-6731
publication_status: published
publisher: Genetics Society of America
publist_id: '2753'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The effective size of a subdivided population
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 146
year: '1997'
...
---
_id: '3631'
abstract:
- lang: eng
text: In spatially heterogeneous environments, natural selection for maintenance
of adaptation to habitats that contribute little to the population's reproduction
is weak. In this paper we model a mechanism that can result in loss of fitness
in such marginal habitats, and thus lead to specialisation on the main habitat.
It involves accumulation of mutations that are deleterious in the marginal habitat
but neutral or nearly so in the main habitat (mutations deleterious in the main
habitat and neutral in the marginal habitat have a negligible influence). If the
contribution of the marginal habitat to total reproduction in the absence of the
mutations is less than a threshold value, selection is too weak to counter accumulation
of such mutations. A positive feedback then results in loss of fitness in the
marginal habitat. This mechanism does not require antagonistic pleiotropy in adaptation
to different habitats, although antagonistic pleiotropy facilitates the mutational
collapse of fitness in the marginal habitat. We suggest that deleterious mutations
with habitat-specific expression may play a role in the evolution of ecological
specialisation and promote evolutionary conservatism of ecological niches.
article_processing_charge: No
article_type: original
author:
- first_name: Tadeusz
full_name: Kawecki, Tadeusz
last_name: Kawecki
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: James
full_name: Fry, James
last_name: Fry
citation:
ama: Kawecki T, Barton NH, Fry J. Mutational collapse of fitness in marginal habitats
and the evolution of ecological specialisation. Journal of Evolutionary Biology.
1997;10(3):407-430. doi:10.1046/j.1420-9101.1997.10030407.x
apa: Kawecki, T., Barton, N. H., & Fry, J. (1997). Mutational collapse of fitness
in marginal habitats and the evolution of ecological specialisation. Journal
of Evolutionary Biology. Wiley-Blackwell. https://doi.org/10.1046/j.1420-9101.1997.10030407.x
chicago: Kawecki, Tadeusz, Nicholas H Barton, and James Fry. “Mutational Collapse
of Fitness in Marginal Habitats and the Evolution of Ecological Specialisation.”
Journal of Evolutionary Biology. Wiley-Blackwell, 1997. https://doi.org/10.1046/j.1420-9101.1997.10030407.x.
ieee: T. Kawecki, N. H. Barton, and J. Fry, “Mutational collapse of fitness in marginal
habitats and the evolution of ecological specialisation,” Journal of Evolutionary
Biology, vol. 10, no. 3. Wiley-Blackwell, pp. 407–430, 1997.
ista: Kawecki T, Barton NH, Fry J. 1997. Mutational collapse of fitness in marginal
habitats and the evolution of ecological specialisation. Journal of Evolutionary
Biology. 10(3), 407–430.
mla: Kawecki, Tadeusz, et al. “Mutational Collapse of Fitness in Marginal Habitats
and the Evolution of Ecological Specialisation.” Journal of Evolutionary Biology,
vol. 10, no. 3, Wiley-Blackwell, 1997, pp. 407–30, doi:10.1046/j.1420-9101.1997.10030407.x.
short: T. Kawecki, N.H. Barton, J. Fry, Journal of Evolutionary Biology 10 (1997)
407–430.
date_created: 2018-12-11T12:04:20Z
date_published: 1997-05-01T00:00:00Z
date_updated: 2022-08-19T09:46:51Z
day: '01'
doi: 10.1046/j.1420-9101.1997.10030407.x
extern: '1'
intvolume: ' 10'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1420-9101.1997.10030407.x
month: '05'
oa: 1
oa_version: Published Version
page: 407 - 430
publication: Journal of Evolutionary Biology
publication_identifier:
issn:
- 1010-061X
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2752'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mutational collapse of fitness in marginal habitats and the evolution of ecological
specialisation
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 10
year: '1997'
...
---
_id: '4018'
abstract:
- lang: eng
text: Given a subspace X subset of or equal to R-d and a finite set S subset of
or equal to R-d, we introduce the Delaunay complex, D-X, restricted by X. Its
simplices are spanned by subsets T subset of or equal to S for which the common
intersection of Voronoi cells meets X in a non-empty set. By the nerve theorem,
boolean OR D-X and X are homotopy equivalent if all such sets are contractible.
This paper proves a sufficient condition for boolean OR D-X and X be homeomorphic.
acknowledgement: Partially supported by the National Science Foundation, under grant
ASC-200301 and the Alan T. Waterman award, grant CCR-9118874.
article_processing_charge: No
article_type: original
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Nimish
full_name: Shah, Nimish
last_name: Shah
citation:
ama: Edelsbrunner H, Shah N. Triangulating topological spaces. International
Journal of Computational Geometry & Applications. 1997;7(4):365-378. doi:10.1142/S0218195997000223
apa: Edelsbrunner, H., & Shah, N. (1997). Triangulating topological spaces.
International Journal of Computational Geometry & Applications. World
Scientific Publishing. https://doi.org/10.1142/S0218195997000223
chicago: Edelsbrunner, Herbert, and Nimish Shah. “Triangulating Topological Spaces.”
International Journal of Computational Geometry & Applications. World
Scientific Publishing, 1997. https://doi.org/10.1142/S0218195997000223.
ieee: H. Edelsbrunner and N. Shah, “Triangulating topological spaces,” International
Journal of Computational Geometry & Applications, vol. 7, no. 4. World
Scientific Publishing, pp. 365–378, 1997.
ista: Edelsbrunner H, Shah N. 1997. Triangulating topological spaces. International
Journal of Computational Geometry & Applications. 7(4), 365–378.
mla: Edelsbrunner, Herbert, and Nimish Shah. “Triangulating Topological Spaces.”
International Journal of Computational Geometry & Applications, vol.
7, no. 4, World Scientific Publishing, 1997, pp. 365–78, doi:10.1142/S0218195997000223.
short: H. Edelsbrunner, N. Shah, International Journal of Computational Geometry
& Applications 7 (1997) 365–378.
date_created: 2018-12-11T12:06:28Z
date_published: 1997-01-01T00:00:00Z
date_updated: 2022-08-19T08:32:23Z
day: '01'
doi: 10.1142/S0218195997000223
extern: '1'
intvolume: ' 7'
issue: '4'
language:
- iso: eng
month: '01'
oa_version: None
page: 365 - 378
publication: International Journal of Computational Geometry & Applications
publication_identifier:
issn:
- 0925-7721
publication_status: published
publisher: World Scientific Publishing
publist_id: '2106'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Triangulating topological spaces
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 7
year: '1997'
...
---
_id: '4174'
abstract:
- lang: eng
text: The epiphysial region of the dorsal diencephalon is the first site at which
neurogenesis occurs in the roof of the zebrafish forebrain. We show that the homeobox
containing gene floating head (flh) is required for neurogenesis to proceed in
the epiphysis. In flh(-) embryos, the first few epiphysial neurons are generated,
but beyond the 18 somite stage, neuronal production ceases. In contrast, in masterblind(-)
(mbl(-)) embryos, epiphysial neurons are generated throughout the dorsal forebrain.
We show that mbl is required to prevent the expression of flh in dorsal forebrain
cells rostral to the epiphysis. Furthermore, epiphysial neurons are not ectopically
induced in mbl(-)/flh(-) embryos, demonstrating that the epiphysial phenotype
of mbl(-) embryos is mediated by ectopic Flh activity. We propose a role for Flh
in linking the signaling pathways that regulate regional patterning to the signaling
pathways that regulate neurogenesis.
acknowledgement: 'We thank Igor DaMd. Tom Jessell, David Kimelman. Vladimir Koah,
Karen Larison. Ingvild Mikkola, Laurie Molday. and Eric Weinberg for probes and
antibod-ies: Alex Schist and Juliet Williams for help with the TUNEL tech-nique;
Dominic Delaney for analysis of the fih neural plate: Brian Gashing and Geraldine
Millard for fish care; Christian Nusslein Volhard for her support: and Corinne Houart.
Nigel Holder, and other members of the DBRC for comments on the manuscript. Electron
microscopy of the developing epiphysis cited in this study was carried out with
the help of Celeste Malinoski. funded by a grant (EY-00168)awarded to Stephen S.
Easter. This study was supported by grants from Welcome Trust to S. W. and Human
Frontier Science Program to I. M. S.W. is a Wellcome Trust Senior Research Fellow. '
article_processing_charge: No
article_type: original
author:
- first_name: Ichiro
full_name: Masai, Ichiro
last_name: Masai
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: K Anukampa
full_name: Barth, K Anukampa
last_name: Barth
- first_name: Rachel
full_name: Macdonald, Rachel
last_name: Macdonald
- first_name: Sylwia
full_name: Adamek, Sylwia
last_name: Adamek
- first_name: Stephen
full_name: Wilson, Stephen
last_name: Wilson
citation:
ama: Masai I, Heisenberg C-PJ, Barth KA, Macdonald R, Adamek S, Wilson S. Floating
head and masterblind regulate neuronal patterning in the roof of the forebrain.
Neuron. 1997;18(1):43-57. doi:10.1016/S0896-6273(01)80045-3
apa: Masai, I., Heisenberg, C.-P. J., Barth, K. A., Macdonald, R., Adamek, S., &
Wilson, S. (1997). Floating head and masterblind regulate neuronal patterning
in the roof of the forebrain. Neuron. Elsevier. https://doi.org/10.1016/S0896-6273(01)80045-3
chicago: Masai, Ichiro, Carl-Philipp J Heisenberg, K Anukampa Barth, Rachel Macdonald,
Sylwia Adamek, and Stephen Wilson. “Floating Head and Masterblind Regulate Neuronal
Patterning in the Roof of the Forebrain.” Neuron. Elsevier, 1997. https://doi.org/10.1016/S0896-6273(01)80045-3.
ieee: I. Masai, C.-P. J. Heisenberg, K. A. Barth, R. Macdonald, S. Adamek, and S.
Wilson, “Floating head and masterblind regulate neuronal patterning in the roof
of the forebrain,” Neuron, vol. 18, no. 1. Elsevier, pp. 43–57, 1997.
ista: Masai I, Heisenberg C-PJ, Barth KA, Macdonald R, Adamek S, Wilson S. 1997.
Floating head and masterblind regulate neuronal patterning in the roof of the
forebrain. Neuron. 18(1), 43–57.
mla: Masai, Ichiro, et al. “Floating Head and Masterblind Regulate Neuronal Patterning
in the Roof of the Forebrain.” Neuron, vol. 18, no. 1, Elsevier, 1997,
pp. 43–57, doi:10.1016/S0896-6273(01)80045-3.
short: I. Masai, C.-P.J. Heisenberg, K.A. Barth, R. Macdonald, S. Adamek, S. Wilson,
Neuron 18 (1997) 43–57.
date_created: 2018-12-11T12:07:24Z
date_published: 1997-01-01T00:00:00Z
date_updated: 2022-08-18T14:02:49Z
day: '01'
doi: 10.1016/S0896-6273(01)80045-3
extern: '1'
external_id:
pmid:
- '9010204'
intvolume: ' 18'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/S0896627301800453?via%3Dihub
month: '01'
oa: 1
oa_version: Published Version
page: 43 - 57
pmid: 1
publication: Neuron
publication_identifier:
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
publist_id: '1946'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Floating head and masterblind regulate neuronal patterning in the roof of the
forebrain
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 18
year: '1997'
...
---
_id: '4201'
abstract:
- lang: eng
text: In zebrafish, as in other vertebrates, an initially singular eye held within
the neural plate has to split during morphogenesis to allow the development of
two separated eyes. It has been suggested that anterior progression of midline
tissue within the neural plate is involved in the bilateralization of the eye
held. Mutations in the recently identified silberblick (slb) gene cause an incomplete
separation of the eyes. During gastrulation and early somitogenesis, the ventral
midline of the central nervous system (CNS) together with the underlying axial
mesendoderm is shortened and broadened in slb embryos. While in wild-type embryos
the ventral CNS midline extends to the anterior limit of the neural plate at the
end of gastrulation, there is a gap between the anterior tip of the ventral CNS
midline and the anterior edge of the neural plate in slb. To investigate the cause
for the shortening of the ventral CNS midline in slb we determined the fate of
labeled ventral CNS midline cells in wild-type and slb embryos at different stages
of development. In slb, anterior migration of ventral CNS midline cells is impaired,
which indicates that migration of these cells is needed for elongation of the
ventral CNS midline. The anterior shortening of the ventral CNS midline in slb
leads to medial instead of bilateral induction of optic stalks followed by a partial
fusion of the eyes at later developmental stages. The analysis of the sIb phenotype
indicates that anterior migration of midline cells within the neural plate is
required for proper induction and subsequent bilateralization of an initially
singular eye field. These findings may therefore provide a starting point in elucidating
the role of neural plate morphogenesis in positioning of the eyes. (C) 1997 Academic
Press.
acknowledgement: 'We thank C. Thisse and Q. Xu for the kind gift of hggl and rtk2
cDNA, respectively. We are grateful to S. Wilson and R. Warga for many valuable
comments on earlier versions of this manuscript. We also thank R. Geisler, D. Gilmour,
M. Granato, I Odenthal, F. Pellegri, S. Schulte-Merker, and F. v. Eeden for critical
reading of the manuscript. '
article_processing_charge: No
article_type: original
author:
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Heisenberg C-PJ, Nüsslein Volhard C. The function of silberblick in the positioning
of the eye anlage in the zebrafish embryo. Developmental Biology. 1997;184(1):85-94.
doi:10.1006/dbio.1997.8511
apa: Heisenberg, C.-P. J., & Nüsslein Volhard, C. (1997). The function of silberblick
in the positioning of the eye anlage in the zebrafish embryo. Developmental
Biology. Elsevier. https://doi.org/10.1006/dbio.1997.8511
chicago: Heisenberg, Carl-Philipp J, and Christiane Nüsslein Volhard. “The Function
of Silberblick in the Positioning of the Eye Anlage in the Zebrafish Embryo.”
Developmental Biology. Elsevier, 1997. https://doi.org/10.1006/dbio.1997.8511.
ieee: C.-P. J. Heisenberg and C. Nüsslein Volhard, “The function of silberblick
in the positioning of the eye anlage in the zebrafish embryo,” Developmental
Biology, vol. 184, no. 1. Elsevier, pp. 85–94, 1997.
ista: Heisenberg C-PJ, Nüsslein Volhard C. 1997. The function of silberblick in
the positioning of the eye anlage in the zebrafish embryo. Developmental Biology.
184(1), 85–94.
mla: Heisenberg, Carl-Philipp J., and Christiane Nüsslein Volhard. “The Function
of Silberblick in the Positioning of the Eye Anlage in the Zebrafish Embryo.”
Developmental Biology, vol. 184, no. 1, Elsevier, 1997, pp. 85–94, doi:10.1006/dbio.1997.8511.
short: C.-P.J. Heisenberg, C. Nüsslein Volhard, Developmental Biology 184 (1997)
85–94.
date_created: 2018-12-11T12:07:33Z
date_published: 1997-04-01T00:00:00Z
date_updated: 2022-08-18T13:54:19Z
day: '01'
doi: 10.1006/dbio.1997.8511
extern: '1'
external_id:
pmid:
- '9142986 '
intvolume: ' 184'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/S0012160697985110?via%3Dihub
month: '04'
oa: 1
oa_version: Published Version
page: 85 - 94
pmid: 1
publication: Developmental Biology
publication_identifier:
eissn:
- 0012-1606
publication_status: published
publisher: Elsevier
publist_id: '1917'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The function of silberblick in the positioning of the eye anlage in the zebrafish
embryo
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 184
year: '1997'
...
---
_id: '4285'
abstract:
- lang: eng
text: One of the oldest hypotheses for the advantage of recombination is that recombination
allo rvs beneficial mutations that arise in different individuals to be placed
together on the same chromosome. Unless recombination occurs, one of the beneficial
alleles is doomed to extinction, slowing the rate at which adaptive mutations
are incorporated within a population. We model the effects of a modifier of recombination
on the fixation probability of beneficial mutations when beneficial alleles are
segregating at other loci. We find that modifier alleles that increase recombination
do increase the fixation probability of beneficial mutants and subsequently hitchhike
along as the mutants rise in frequency. The strength of selection favoring a modifier
that increases recombination is proportional to lambda(2)S delta r/r when linkage
is tight and lambda(2)S(3) delta r/N when linkage is loose, where lambda is the
beneficial mutation rate per genome per generation throughout a population of
size N, S is the average mutant effect, r is the average recombination rate, and
delta ris the amount that recombination is modified. We conclude that selection
for recombination will be substantial only if there is tight linkage within the
genome or if many loci are subject to directional selection as during periods
of rapid evolutionary change.
article_processing_charge: No
article_type: original
author:
- first_name: Sarah
full_name: Otto, Sarah
last_name: Otto
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: 'Otto S, Barton NH. The evolution of recombination: Removing the limits to
natural selection. Genetics. 1997;147(2):879-906. doi:10.1093/genetics/147.2.879'
apa: 'Otto, S., & Barton, N. H. (1997). The evolution of recombination: Removing
the limits to natural selection. Genetics. Genetics Society of America.
https://doi.org/10.1093/genetics/147.2.879'
chicago: 'Otto, Sarah, and Nicholas H Barton. “The Evolution of Recombination: Removing
the Limits to Natural Selection.” Genetics. Genetics Society of America,
1997. https://doi.org/10.1093/genetics/147.2.879.'
ieee: 'S. Otto and N. H. Barton, “The evolution of recombination: Removing the limits
to natural selection,” Genetics, vol. 147, no. 2. Genetics Society of America,
pp. 879–906, 1997.'
ista: 'Otto S, Barton NH. 1997. The evolution of recombination: Removing the limits
to natural selection. Genetics. 147(2), 879–906.'
mla: 'Otto, Sarah, and Nicholas H. Barton. “The Evolution of Recombination: Removing
the Limits to Natural Selection.” Genetics, vol. 147, no. 2, Genetics Society
of America, 1997, pp. 879–906, doi:10.1093/genetics/147.2.879.'
short: S. Otto, N.H. Barton, Genetics 147 (1997) 879–906.
date_created: 2018-12-11T12:08:02Z
date_published: 1997-10-01T00:00:00Z
date_updated: 2022-08-18T11:36:10Z
day: '01'
doi: 10.1093/genetics/147.2.879
extern: '1'
external_id:
pmid:
- '9335621'
intvolume: ' 147'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://academic.oup.com/genetics/article/147/2/879/6054161
month: '10'
oa: 1
oa_version: Published Version
page: 879 - 906
pmid: 1
publication: Genetics
publication_identifier:
issn:
- 0016-6731
publication_status: published
publisher: Genetics Society of America
publist_id: '1796'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'The evolution of recombination: Removing the limits to natural selection'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 147
year: '1997'
...
---
_id: '4284'
abstract:
- lang: eng
text: The evolutionary processes responsible for adaptation and speciation on islands
differ in several ways from those on the mainland. Most attention has been given
to the random genetic drift that arises when a population is founded from just
a few colonizing genomes. Theoretical obstacles to ‘founder effect speciation’
are discussed, together with recent proposals for avoiding them. It is argued
that although certain kinds of epistasis can facilitate the evolution of strong
reproductive isolation, this favours divergence by selection as much as by random
drift.
article_processing_charge: No
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: 'Barton NH. Natural selection and random genetic drift as causes of evolution
on islands. In: Evolution on Islands. Oxford University Press; 1997:102-123.
doi:10.1098/rstb.1996.0073'
apa: Barton, N. H. (1997). Natural selection and random genetic drift as causes
of evolution on islands. In Evolution on islands (pp. 102–123). Oxford
University Press. https://doi.org/10.1098/rstb.1996.0073
chicago: Barton, Nicholas H. “Natural Selection and Random Genetic Drift as Causes
of Evolution on Islands.” In Evolution on Islands, 102–23. Oxford University
Press, 1997. https://doi.org/10.1098/rstb.1996.0073.
ieee: N. H. Barton, “Natural selection and random genetic drift as causes of evolution
on islands,” in Evolution on islands, Oxford University Press, 1997, pp.
102–123.
ista: 'Barton NH. 1997.Natural selection and random genetic drift as causes of evolution
on islands. In: Evolution on islands. , 102–123.'
mla: Barton, Nicholas H. “Natural Selection and Random Genetic Drift as Causes of
Evolution on Islands.” Evolution on Islands, Oxford University Press, 1997,
pp. 102–23, doi:10.1098/rstb.1996.0073.
short: N.H. Barton, in:, Evolution on Islands, Oxford University Press, 1997, pp.
102–123.
date_created: 2018-12-11T12:08:02Z
date_published: 1997-11-27T00:00:00Z
date_updated: 2022-08-18T13:04:36Z
day: '27'
doi: 10.1098/rstb.1996.0073
extern: '1'
external_id:
pmid:
- '8693020'
language:
- iso: eng
month: '11'
oa_version: None
page: 102 - 123
pmid: 1
publication: Evolution on islands
publication_identifier:
isbn:
- '9780198501718'
publication_status: published
publisher: Oxford University Press
publist_id: '1800'
quality_controlled: '1'
status: public
title: Natural selection and random genetic drift as causes of evolution on islands
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '1997'
...
---
_id: '4438'
abstract:
- lang: eng
text: "In temporal-logic model checking, we verify the correctness of a program
with respect to a desired behavior by checking whether a structure that models
the program satisfies a temporal-logic formula that specifies the behavior. The
model-checking problem for the branching-time temporal logic CTL can be solved
in linear running time, and model-checking tools for CTL are used successfully
in industrial applications. The development of programs that must meet rigid real-time
constraints has brought with it a need for real-time temporal logics that enable
quantitative reference to time. Early research on real-time temporal logics uses
the discrete domain of the integers to model time. Present research on real-time
temporal logics focuses on continuous time and uses the dense domain of the reals
to model time. There, model checking becomes significantly more complicated. For
example, the model-checking problem for TCTL, a continuous-time extension of the
logic CTL, is PSPACE-complete.\r\nIn this paper we suggest a reduction from TCTL
model checking to CTL model checking. The contribution of such a reduction is
twofold. Theoretically, while it has long been known that model-checking methods
for untimed temporal logics can be extended quite easily to handle discrete time,
it was not clear whether and how untimed methods can handle the reset quantifier
of TCTL, which resets a realvalued clock. Practically, our reduction enables anyone
who has a tool for CTL model checking to use it for TCTL model checking. The TCTL
model-checking algorithm that follows from our reduction is in PSPACE, matching
the known bound for this problem. In addition, it enjoys the wide distribution
of CTL model-checking tools and the extensive and fruitful research efforts and
heuristics that have been put into these tools."
acknowledgement: This research was supported in part by the ONR YIP award N00014-95-1-0520,
by the NSF CAREER award CCR-9501708, by the NSF grant CCR-9504469, by the AFOSR
contract F49620-93-1-0056, by the ARO MURI grant DAAH-04-96-1-0341, by the ARPA
grant NAG2-892, and by the SRC contract 95-DC-324.036.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Orna
full_name: Kupferman, Orna
last_name: Kupferman
citation:
ama: 'Henzinger TA, Kupferman O. From quantity to quality. In: Proceedings of
the 5th International Workshop on Hybrid and Real-Time Systems. Vol 1201.
Springer; 1997:48-62. doi:10.1007/BFb0014712'
apa: 'Henzinger, T. A., & Kupferman, O. (1997). From quantity to quality. In
Proceedings of the 5th International Workshop on Hybrid and Real-Time Systems
(Vol. 1201, pp. 48–62). Grenoble, France: Springer. https://doi.org/10.1007/BFb0014712'
chicago: Henzinger, Thomas A, and Orna Kupferman. “From Quantity to Quality.” In
Proceedings of the 5th International Workshop on Hybrid and Real-Time Systems,
1201:48–62. Springer, 1997. https://doi.org/10.1007/BFb0014712.
ieee: T. A. Henzinger and O. Kupferman, “From quantity to quality,” in Proceedings
of the 5th International Workshop on Hybrid and Real-Time Systems, Grenoble,
France, 1997, vol. 1201, pp. 48–62.
ista: 'Henzinger TA, Kupferman O. 1997. From quantity to quality. Proceedings of
the 5th International Workshop on Hybrid and Real-Time Systems. HART: Hybrid and
Real-Time Systems, LNCS, vol. 1201, 48–62.'
mla: Henzinger, Thomas A., and Orna Kupferman. “From Quantity to Quality.” Proceedings
of the 5th International Workshop on Hybrid and Real-Time Systems, vol. 1201,
Springer, 1997, pp. 48–62, doi:10.1007/BFb0014712.
short: T.A. Henzinger, O. Kupferman, in:, Proceedings of the 5th International Workshop
on Hybrid and Real-Time Systems, Springer, 1997, pp. 48–62.
conference:
end_date: 1997-03-28
location: Grenoble, France
name: 'HART: Hybrid and Real-Time Systems'
start_date: 1997-03-26
date_created: 2018-12-11T12:08:51Z
date_published: 1997-01-01T00:00:00Z
date_updated: 2022-08-17T12:29:48Z
day: '01'
doi: 10.1007/BFb0014712
extern: '1'
intvolume: ' 1201'
language:
- iso: eng
month: '01'
oa_version: None
page: 48 - 62
publication: Proceedings of the 5th International Workshop on Hybrid and Real-Time
Systems
publication_identifier:
isbn:
- '9783540626008'
publication_status: published
publisher: Springer
publist_id: '291'
quality_controlled: '1'
scopus_import: '1'
status: public
title: From quantity to quality
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1201
year: '1997'
...
---
_id: '4441'
abstract:
- lang: eng
text: Rectangular hybrid automata model digital control programs of analog plant
environments. We study rectangular hybrid automata where the plant state evolves
continuously in real-numbered time, and the controller samples the plant state
and changes the control state discretely, only at the integer points in time.
We prove that rectangular hybrid automata have finite bisimilarity quotients when
all control transitions happen at integer times, even if the constraints on the
derivatives of the variables vary between control states. This is sharply in contrast
with the conventional model where control transitions may happen at any real time,
and already the reachability problem is undecidable. Based on the finite bisimilarity
quotients, we give an exponential algorithm for the symbolic sampling-controller
synthesis of rectangular automata. We show our algorithm to be optimal by proving
the problem to be EXPTIME-hard. We also show that rectangular automata form a
maximal class of systems for which the sampling-controller synthesis problem can
be solved algorithmically.
acknowledgement: This research was supported in part by the ONR YIP award N00014-95-1-0520,
by the NSF CAREER award CCR-9501708, by the NSF grant CCR-9504469, by the AFOSR
contract F49620-93-1-0056, by the ARO MURI contract DAAH-04-96-1-0341, by the ARO
contract DAAL03-91-C-0027 through the MSI at Cornell University, by the ARPA grant
NAG2-892, and by the SRC contract 95-DC-324.036.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Peter
full_name: Kopke, Peter
last_name: Kopke
citation:
ama: 'Henzinger TA, Kopke P. Discrete-time control for rectangular hybrid automata.
In: Proceedings of the 24th International Colloquium on Automata, Languages
and Programming. Vol 1256. Springer; 1997:582-593. doi:10.1007/3-540-63165-8_213'
apa: 'Henzinger, T. A., & Kopke, P. (1997). Discrete-time control for rectangular
hybrid automata. In Proceedings of the 24th International Colloquium on Automata,
Languages and Programming (Vol. 1256, pp. 582–593). Bologna, Italy: Springer.
https://doi.org/10.1007/3-540-63165-8_213'
chicago: Henzinger, Thomas A, and Peter Kopke. “Discrete-Time Control for Rectangular
Hybrid Automata.” In Proceedings of the 24th International Colloquium on Automata,
Languages and Programming, 1256:582–93. Springer, 1997. https://doi.org/10.1007/3-540-63165-8_213.
ieee: T. A. Henzinger and P. Kopke, “Discrete-time control for rectangular hybrid
automata,” in Proceedings of the 24th International Colloquium on Automata,
Languages and Programming, Bologna, Italy, 1997, vol. 1256, pp. 582–593.
ista: 'Henzinger TA, Kopke P. 1997. Discrete-time control for rectangular hybrid
automata. Proceedings of the 24th International Colloquium on Automata, Languages
and Programming. ICALP: Automata, Languages and Programming, LNCS, vol. 1256,
582–593.'
mla: Henzinger, Thomas A., and Peter Kopke. “Discrete-Time Control for Rectangular
Hybrid Automata.” Proceedings of the 24th International Colloquium on Automata,
Languages and Programming, vol. 1256, Springer, 1997, pp. 582–93, doi:10.1007/3-540-63165-8_213.
short: T.A. Henzinger, P. Kopke, in:, Proceedings of the 24th International Colloquium
on Automata, Languages and Programming, Springer, 1997, pp. 582–593.
conference:
end_date: 1997-07-11
location: Bologna, Italy
name: 'ICALP: Automata, Languages and Programming'
start_date: 1997-07-07
date_created: 2018-12-11T12:08:52Z
date_published: 1997-01-01T00:00:00Z
date_updated: 2022-08-17T12:04:15Z
day: '01'
doi: 10.1007/3-540-63165-8_213
extern: '1'
intvolume: ' 1256'
language:
- iso: eng
month: '01'
oa_version: None
page: 582 - 593
publication: Proceedings of the 24th International Colloquium on Automata, Languages
and Programming
publication_identifier:
isbn:
- '9783540631651'
publication_status: published
publisher: Springer
publist_id: '289'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Discrete-time control for rectangular hybrid automata
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1256
year: '1997'
...
---
_id: '4496'
abstract:
- lang: eng
text: 'The simulation preorder for labeled transition systems is defined locally
as a game that relates states with their immediate successor states. Liveness
assumptions about transition systems are typically modeled using fairness constraints.
Existing notions of simulation for fair transition systems, however, are not local,
and as a result, many appealing properties of the simulation preorder are lost.
We extend the local definition of simulation to account for fairness: system S
fairly simulates system I iff in the simulation game, there is a strategy that
matches with each fair computation of I a fair computation of S. Our definition
enjoys a fully abstract semantics and has a logical characterization: S fairly
simulates I iff every fair computation tree embedded in the unrolling of I can
be embedded also in the unrolling of S or, equivalently, iff every Fair-AFMC formula
satisfied by I is satisfied also by S (AFMC is the universal fragment of the alternation-free
-calculus). The locality of the definition leads us to a polynomial-time algorithm
for checking fair simulation for finite-state systems with weak and strong fairness
constraints. Finally, fair simulation implies fair trace-containment, and is therefore
useful as an efficientlycomputable local criterion for proving linear-time abstraction
hierarchies.'
acknowledgement: This research was supported in part by the ONR YIP award N00014-95-1-0520,
by the NSF CAREER award CCR-9501708, by the NSF grant CCR-9504469, by the AFOSR
contract F49620-93-1-0056, by the ARO MURI grant DAAH-04-96-1-0341, by the ARPA
grant NAG2-892, and by the SRC contract 95-DC-324.036.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Orna
full_name: Kupferman, Orna
last_name: Kupferman
- first_name: Sriram
full_name: Rajamani, Sriram
last_name: Rajamani
citation:
ama: 'Henzinger TA, Kupferman O, Rajamani S. Fair simulation. In: Proceedings
of the 8th International Conference on Concurrency Theory. Vol 1243. Springer;
1997:273-287. doi:10.1007/3-540-63141-0_19'
apa: 'Henzinger, T. A., Kupferman, O., & Rajamani, S. (1997). Fair simulation.
In Proceedings of the 8th International Conference on Concurrency Theory
(Vol. 1243, pp. 273–287). Warsaw, Poland: Springer. https://doi.org/10.1007/3-540-63141-0_19'
chicago: Henzinger, Thomas A, Orna Kupferman, and Sriram Rajamani. “Fair Simulation.”
In Proceedings of the 8th International Conference on Concurrency Theory,
1243:273–87. Springer, 1997. https://doi.org/10.1007/3-540-63141-0_19.
ieee: T. A. Henzinger, O. Kupferman, and S. Rajamani, “Fair simulation,” in Proceedings
of the 8th International Conference on Concurrency Theory, Warsaw, Poland,
1997, vol. 1243, pp. 273–287.
ista: 'Henzinger TA, Kupferman O, Rajamani S. 1997. Fair simulation. Proceedings
of the 8th International Conference on Concurrency Theory. CONCUR: Concurrency
Theory, LNCS, vol. 1243, 273–287.'
mla: Henzinger, Thomas A., et al. “Fair Simulation.” Proceedings of the 8th International
Conference on Concurrency Theory, vol. 1243, Springer, 1997, pp. 273–87, doi:10.1007/3-540-63141-0_19.
short: T.A. Henzinger, O. Kupferman, S. Rajamani, in:, Proceedings of the 8th International
Conference on Concurrency Theory, Springer, 1997, pp. 273–287.
conference:
end_date: 1997-07-04
location: Warsaw, Poland
name: 'CONCUR: Concurrency Theory'
start_date: 1997-07-01
date_created: 2018-12-11T12:09:09Z
date_published: 1997-01-01T00:00:00Z
date_updated: 2022-08-17T09:09:13Z
day: '01'
doi: 10.1007/3-540-63141-0_19
extern: '1'
intvolume: ' 1243'
language:
- iso: eng
month: '01'
oa_version: None
page: 273 - 287
publication: Proceedings of the 8th International Conference on Concurrency Theory
publication_identifier:
isbn:
- '9783540631415'
publication_status: published
publisher: Springer
publist_id: '234'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Fair simulation
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1243
year: '1997'
...
---
_id: '4494'
abstract:
- lang: eng
text: A hybrid system consists of a collection of digital programs that interact
with each other and with an analog environment. Examples of hybrid systems include
medical equipment, manufacturing controllers, automotive controllers, and robots.
The formal analysis of the mixed digital-analog nature of these systems requires
a model that incorporates the discrete behavior of computer programs with the
continuous behavior of environment variables, such as temperature and pressure.
Hybrid automata capture both types of behavior by combining finite automata with
differential inclusions (i.e. differential inequalities). HyTech is a symbolic
model checker for linear hybrid automata, an expressive, yet automatically analyzable,
subclass of hybrid automata. A key feature of HyTech is its ability to perform
parametric analysis, i.e. to determine the values of design parameters for which
a linear hybrid automaton satisfies a temporal requirement.
acknowledgement: This research was supported in part by the ONR YIP award N00014-95-1-0520,
by the NSF CAREER award CCR-9501708, by the NSF grant CCR-9504469, by the AFOSR
contract F49620-93-1-0056, by the ARO MURI grant DAAH-04-96-1-0341, by the ARPA
grant NAG2-892, and by the SRC contract 95-DC-324.036.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Pei
full_name: Ho, Pei
last_name: Ho
- first_name: Howard
full_name: Wong Toi, Howard
last_name: Wong Toi
citation:
ama: 'Henzinger TA, Ho P, Wong Toi H. HyTech: A model checker for hybrid systems.
In: Vol 1254. Springer; 1997:460-463. doi:10.1007/3-540-63166-6_48'
apa: 'Henzinger, T. A., Ho, P., & Wong Toi, H. (1997). HyTech: A model checker
for hybrid systems (Vol. 1254, pp. 460–463). Presented at the CAV: Computer Aided
Verification, Haifa, Israel: Springer. https://doi.org/10.1007/3-540-63166-6_48'
chicago: 'Henzinger, Thomas A, Pei Ho, and Howard Wong Toi. “HyTech: A Model Checker
for Hybrid Systems,” 1254:460–63. Springer, 1997. https://doi.org/10.1007/3-540-63166-6_48.'
ieee: 'T. A. Henzinger, P. Ho, and H. Wong Toi, “HyTech: A model checker for hybrid
systems,” presented at the CAV: Computer Aided Verification, Haifa, Israel, 1997,
vol. 1254, pp. 460–463.'
ista: 'Henzinger TA, Ho P, Wong Toi H. 1997. HyTech: A model checker for hybrid
systems. CAV: Computer Aided Verification, LNCS, vol. 1254, 460–463.'
mla: 'Henzinger, Thomas A., et al. HyTech: A Model Checker for Hybrid Systems.
Vol. 1254, Springer, 1997, pp. 460–63, doi:10.1007/3-540-63166-6_48.'
short: T.A. Henzinger, P. Ho, H. Wong Toi, in:, Springer, 1997, pp. 460–463.
conference:
end_date: 1997-06-25
location: Haifa, Israel
name: 'CAV: Computer Aided Verification'
start_date: 1997-06-22
date_created: 2018-12-11T12:09:08Z
date_published: 1997-01-01T00:00:00Z
date_updated: 2022-08-17T11:06:13Z
day: '01'
doi: 10.1007/3-540-63166-6_48
extern: '1'
intvolume: ' 1254'
language:
- iso: eng
month: '01'
oa_version: None
page: 460 - 463
publication_identifier:
isbn:
- '9783540631668'
publication_status: published
publisher: Springer
publist_id: '235'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'HyTech: A model checker for hybrid systems'
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1254
year: '1997'
...
---
_id: '4493'
abstract:
- lang: eng
text: A hybrid system is a dynamical system whose behavior exhibits both discrete
and continuous change. A hybrid automaton is a mathematical model for hybrid systems,
which combines, in a single formalism, automaton transitions for capturing discrete
change with differential equations for capturing continuous change. HyTech is
a symbolic model checker for linear hybrid automata, a subclass of hybrid automata
that can be analyzed automatically by computing with polyhedral state sets. A
key feature of HyTech is its ability to perform parametric analysis, i.e., to
determine the values of design parameters for which a linear hybrid automaton
satisfies a temporal-logic requirement.
acknowledgement: This research was supported in part by the ONR YIP award N00014-95-1-0520,
the NSF CAREER award CCR-501708, NSF grant CCR-9504469, AFOSR contract F49620-93-1-0056,
ARO MURI grant DAAH-04-96-1-0341, ARPA grant AG2-892, and SRC contract 95-DC-324.036.
article_processing_charge: No
article_type: original
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Pei
full_name: Ho, Pei
last_name: Ho
- first_name: Howard
full_name: Wong Toi, Howard
last_name: Wong Toi
citation:
ama: 'Henzinger TA, Ho P, Wong Toi H. HyTech: A model checker for hybrid systems.
Software Tools For Technology Transfer. 1997;1(1-2):110-122. doi:10.1007/s100090050008'
apa: 'Henzinger, T. A., Ho, P., & Wong Toi, H. (1997). HyTech: A model checker
for hybrid systems. Software Tools For Technology Transfer. Springer. https://doi.org/10.1007/s100090050008'
chicago: 'Henzinger, Thomas A, Pei Ho, and Howard Wong Toi. “HyTech: A Model Checker
for Hybrid Systems.” Software Tools For Technology Transfer. Springer,
1997. https://doi.org/10.1007/s100090050008.'
ieee: 'T. A. Henzinger, P. Ho, and H. Wong Toi, “HyTech: A model checker for hybrid
systems,” Software Tools For Technology Transfer, vol. 1, no. 1–2. Springer,
pp. 110–122, 1997.'
ista: 'Henzinger TA, Ho P, Wong Toi H. 1997. HyTech: A model checker for hybrid
systems. Software Tools For Technology Transfer. 1(1–2), 110–122.'
mla: 'Henzinger, Thomas A., et al. “HyTech: A Model Checker for Hybrid Systems.”
Software Tools For Technology Transfer, vol. 1, no. 1–2, Springer, 1997,
pp. 110–22, doi:10.1007/s100090050008.'
short: T.A. Henzinger, P. Ho, H. Wong Toi, Software Tools For Technology Transfer
1 (1997) 110–122.
date_created: 2018-12-11T12:09:08Z
date_published: 1997-01-01T00:00:00Z
date_updated: 2022-08-17T11:14:15Z
day: '01'
doi: 10.1007/s100090050008
extern: '1'
intvolume: ' 1'
issue: 1-2
language:
- iso: eng
month: '01'
oa_version: None
page: 110 - 122
publication: Software Tools For Technology Transfer
publication_identifier:
issn:
- 1433-2779
publication_status: published
publisher: Springer
publist_id: '236'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'HyTech: A model checker for hybrid systems'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1
year: '1997'
...
---
_id: '4520'
abstract:
- lang: eng
text: 'We define robust timed automata, which are timed automata that accept all
trajectories robustly: if a robust timed automaton accepts a trajectory, then
it must accept neighboring trajectories also; and if a robust timed automaton
rejects a trajectory, then it must reject neighboring trajectories also. We show
that the emptiness problem for robust timed automata is still decidable, by modifying
the region construction for timed automata. We then show that, like timed automata,
robust timed automata cannot be determinized. This result is somewhat unexpected,
given that in temporal logic, the removal of realtime equality constraints is
known to lead to a decidable theory that is closed under all boolean operations.'
acknowledgement: The first and third author were supported in part by grants from
ARPA and ONR. The second author was supported in part by the ONR YIP award N00014-95-1-0520,
by the NSF CAREER award CCR-9501708, by the NSF grant CCR-9504469, by the AFOSR
contract F49620-93-1-0056, by the ARO MURI grant DAAH-04-96-1-0341, by the ARPA
grant NAG2-892, and by the SRC contract 95-DC-324.036. The third author was also
supported by the NSF.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Vineet
full_name: Gupta, Vineet
last_name: Gupta
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Radha
full_name: Jagadeesan, Radha
last_name: Jagadeesan
citation:
ama: 'Gupta V, Henzinger TA, Jagadeesan R. Robust timed automata. In: Proceedings
of the 5th International Workshop on Hybrid and Real-Time Systems. Vol 1201.
Springer; 1997:331-345. doi:10.1007/BFb0014736'
apa: 'Gupta, V., Henzinger, T. A., & Jagadeesan, R. (1997). Robust timed automata.
In Proceedings of the 5th International Workshop on Hybrid and Real-Time Systems
(Vol. 1201, pp. 331–345). Grenoble, France: Springer. https://doi.org/10.1007/BFb0014736'
chicago: Gupta, Vineet, Thomas A Henzinger, and Radha Jagadeesan. “Robust Timed
Automata.” In Proceedings of the 5th International Workshop on Hybrid and Real-Time
Systems, 1201:331–45. Springer, 1997. https://doi.org/10.1007/BFb0014736.
ieee: V. Gupta, T. A. Henzinger, and R. Jagadeesan, “Robust timed automata,” in
Proceedings of the 5th International Workshop on Hybrid and Real-Time Systems,
Grenoble, France, 1997, vol. 1201, pp. 331–345.
ista: 'Gupta V, Henzinger TA, Jagadeesan R. 1997. Robust timed automata. Proceedings
of the 5th International Workshop on Hybrid and Real-Time Systems. HART: Hybrid
and Real-Time Systems, LNCS, vol. 1201, 331–345.'
mla: Gupta, Vineet, et al. “Robust Timed Automata.” Proceedings of the 5th International
Workshop on Hybrid and Real-Time Systems, vol. 1201, Springer, 1997, pp. 331–45,
doi:10.1007/BFb0014736.
short: V. Gupta, T.A. Henzinger, R. Jagadeesan, in:, Proceedings of the 5th International
Workshop on Hybrid and Real-Time Systems, Springer, 1997, pp. 331–345.
conference:
end_date: 1997-03-28
location: Grenoble, France
name: 'HART: Hybrid and Real-Time Systems'
start_date: 1997-03-26
date_created: 2018-12-11T12:09:17Z
date_published: 1997-01-01T00:00:00Z
date_updated: 2022-08-17T09:04:39Z
day: '01'
doi: 10.1007/BFb0014736
extern: '1'
intvolume: ' 1201'
language:
- iso: eng
month: '01'
oa_version: None
page: 331 - 345
publication: Proceedings of the 5th International Workshop on Hybrid and Real-Time
Systems
publication_identifier:
isbn:
- '9783540626008'
publication_status: published
publisher: Springer
publist_id: '207'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Robust timed automata
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1201
year: '1997'
...
---
_id: '4583'
abstract:
- lang: eng
text: In a trace-based world, the modular specification, verification, and control
of live systems require each module to be receptive; that is, each module must
be able to meet its liveness assumptions no matter how the other modules behave.
In a real-time world, liveness is automatically present in the form of diverging
time. The receptiveness condition, then, translates to the requirement that a
module must be able to let time diverge no matter how the environment behaves.
We study the receptiveness condition for real-time systems by extending the model
of reactive modules to timed and hybrid modules. We define the receptiveness of
such a module as the existence of a winning strategy in a game of the module against
its environment. By solving the game on region graphs, we present an (optimal)
Exptime algorithm for checking the receptiveness of prepositional timed modules.
By giving a fixpoint characterization of the game, we present a symbolic procedure
for checking the receptiveness of linear hybrid modules. Finally, we present an
assume-guarantee principle for reasoning about timed and hybrid modules, and a
method for synthesizing receptive controllers of timed and hybrid modules.
acknowledgement: This research was supported in part by the ONR YIP award N00014-95-1-0520,
by the NSF CAREER award CCR-9501708, by the NSF grant CCR-9504469, by the AFOSR
contract F49620-93-1-0056, by the ARO MURI grant DAAH-04-96-1-0341, by the ARPA
grant NAG2-892, and by the SRC contract 95-DC-324.036.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Rajeev
full_name: Alur, Rajeev
last_name: Alur
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
citation:
ama: 'Alur R, Henzinger TA. Modularity for timed and hybrid systems. In: 8th
International Conference on Concurrency Theory. Vol 1243. Schloss Dagstuhl
- Leibniz-Zentrum für Informatik; 1997:74-88. doi:10.1007/3-540-63141-0_6'
apa: 'Alur, R., & Henzinger, T. A. (1997). Modularity for timed and hybrid systems.
In 8th International Conference on Concurrency Theory (Vol. 1243, pp. 74–88).
Warsaw, Poland: Schloss Dagstuhl - Leibniz-Zentrum für Informatik. https://doi.org/10.1007/3-540-63141-0_6'
chicago: Alur, Rajeev, and Thomas A Henzinger. “Modularity for Timed and Hybrid
Systems.” In 8th International Conference on Concurrency Theory, 1243:74–88.
Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 1997. https://doi.org/10.1007/3-540-63141-0_6.
ieee: R. Alur and T. A. Henzinger, “Modularity for timed and hybrid systems,” in
8th International Conference on Concurrency Theory, Warsaw, Poland, 1997,
vol. 1243, pp. 74–88.
ista: 'Alur R, Henzinger TA. 1997. Modularity for timed and hybrid systems. 8th
International Conference on Concurrency Theory. CONCUR: Concurrency Theory, LNCS,
vol. 1243, 74–88.'
mla: Alur, Rajeev, and Thomas A. Henzinger. “Modularity for Timed and Hybrid Systems.”
8th International Conference on Concurrency Theory, vol. 1243, Schloss
Dagstuhl - Leibniz-Zentrum für Informatik, 1997, pp. 74–88, doi:10.1007/3-540-63141-0_6.
short: R. Alur, T.A. Henzinger, in:, 8th International Conference on Concurrency
Theory, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 1997, pp. 74–88.
conference:
end_date: 1997-07-04
location: Warsaw, Poland
name: 'CONCUR: Concurrency Theory'
start_date: 1997-07-01
date_created: 2018-12-11T12:09:36Z
date_published: 1997-01-01T00:00:00Z
date_updated: 2022-08-17T08:47:55Z
day: '01'
doi: 10.1007/3-540-63141-0_6
extern: '1'
intvolume: ' 1243'
language:
- iso: eng
month: '01'
oa_version: None
page: 74 - 88
publication: 8th International Conference on Concurrency Theory
publication_identifier:
isbn:
- '9783540691884'
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
publist_id: '124'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Modularity for timed and hybrid systems
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1243
year: '1997'
...
---
_id: '4584'
abstract:
- lang: eng
text: This paper introduces, gently but rigorously, the clock approach to real-time
programming. We present with mathematical precision, assuming no prerequisites
other than familiarity with logical and programming notations, the concepts that
are necessary for understanding, writing, and executing clock programs. In keeping
with an expository style, all references are clustered in bibliographic remarks
at the end of each section. The first appendix presents proof rules for verifying
temporal properties of clock programs. The second appendix points to selected
literature on formal methods and tools for programming with clocks. In particular,
the timed automaton, which is a finite-state machine equipped with clocks, has
become a standard paradigm for real-time model checking; it underlies the tools
HyTech, Kronos, and Uppaal, which are discussed elsewhere in this volume.
acknowledgement: The authors thank Rance Cleaveland, Limor Fix, David Karr, Peter
Kopke, Fred Schneider, and Bernhard Steffen for helpful comments.
article_processing_charge: No
article_type: original
author:
- first_name: Rajeev
full_name: Alur, Rajeev
last_name: Alur
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
citation:
ama: Alur R, Henzinger TA. Real-time system = discrete system + clock variables.
Software Tools For Technology Transfer. 1997;1(1-2):86-109. doi:10.1007/s100090050007
apa: Alur, R., & Henzinger, T. A. (1997). Real-time system = discrete system
+ clock variables. Software Tools For Technology Transfer. Springer. https://doi.org/10.1007/s100090050007
chicago: Alur, Rajeev, and Thomas A Henzinger. “Real-Time System = Discrete System
+ Clock Variables.” Software Tools For Technology Transfer. Springer, 1997.
https://doi.org/10.1007/s100090050007.
ieee: R. Alur and T. A. Henzinger, “Real-time system = discrete system + clock variables,”
Software Tools For Technology Transfer, vol. 1, no. 1–2. Springer, pp.
86–109, 1997.
ista: Alur R, Henzinger TA. 1997. Real-time system = discrete system + clock variables.
Software Tools For Technology Transfer. 1(1–2), 86–109.
mla: Alur, Rajeev, and Thomas A. Henzinger. “Real-Time System = Discrete System
+ Clock Variables.” Software Tools For Technology Transfer, vol. 1, no.
1–2, Springer, 1997, pp. 86–109, doi:10.1007/s100090050007.
short: R. Alur, T.A. Henzinger, Software Tools For Technology Transfer 1 (1997)
86–109.
date_created: 2018-12-11T12:09:36Z
date_published: 1997-01-01T00:00:00Z
date_updated: 2022-08-17T08:27:20Z
day: '01'
doi: 10.1007/s100090050007
extern: '1'
intvolume: ' 1'
issue: 1-2
language:
- iso: eng
month: '01'
oa_version: None
page: 86 - 109
publication: Software Tools For Technology Transfer
publication_identifier:
issn:
- 1433-2779
publication_status: published
publisher: Springer
publist_id: '123'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Real-time system = discrete system + clock variables
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1
year: '1997'
...
---
_id: '4608'
abstract:
- lang: eng
text: 'State space explosion is a fundamental obstacle in formal verification of
designs and protocols. Several techniques for combating this problem have emerged
in the past few years, among which two are significant: partial-order reductions
and symbolic state space search. In asynchronous systems, interleavings of independent
concurrent events are equivalent, and only a representative interleaving needs
to be explored to verify local properties. Partial-order methods exploit this
redundancy and visit only a subset of the reachable states. Symbolic techniques,
on the other hand, capture the transition relation of a system and the set of
reachable states as boolean functions. In many cases, these functions can be represented
compactly using binary decision diagrams (BDDs). Traditionally, the two techniques
have been practiced by two different schools—partial-order methods with enumerative
depth-first search for the analysis of asynchronous network protocols, and symbolic
breadth-first search for the analysis of synchronous hardware designs. We combine
both approaches and develop a method for using partial-order reduction techniques
in symbolic BDD-based invariant checking. We present theoretical results to prove
the correctness of the method, and experimental results to demonstrate its efficacy.'
acknowledgement: This research was supported in part by the ONR YIP award N00014-95-1-0520,
by the NSF CAREER award CCR-9501708, by the NSF grant CCR-9504469, by the AFOSR
contract F49620-93-1-0056, by the ARO MURI grant DAAH-04-96-1-0341, by the ARPA
grant NAG2-892, and by the Semiconductor Research Corporation contracts DC-324.036
and DC-324.005.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Rajeev
full_name: Alur, Rajeev
last_name: Alur
- first_name: Robert
full_name: Brayton, Robert
last_name: Brayton
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Shaz
full_name: Qadeer, Shaz
last_name: Qadeer
- first_name: Sriram
full_name: Rajamani, Sriram
last_name: Rajamani
citation:
ama: 'Alur R, Brayton R, Henzinger TA, Qadeer S, Rajamani S. Partial-order reduction
in symbolic state-space exploration. In: 9th International Conference on Computer
Aided Verification. Vol 1254. Springer; 1997:340-351. doi:10.1007/3-540-63166-6_34'
apa: 'Alur, R., Brayton, R., Henzinger, T. A., Qadeer, S., & Rajamani, S. (1997).
Partial-order reduction in symbolic state-space exploration. In 9th International
Conference on Computer Aided Verification (Vol. 1254, pp. 340–351). Haifa,
Israel: Springer. https://doi.org/10.1007/3-540-63166-6_34'
chicago: Alur, Rajeev, Robert Brayton, Thomas A Henzinger, Shaz Qadeer, and Sriram
Rajamani. “Partial-Order Reduction in Symbolic State-Space Exploration.” In 9th
International Conference on Computer Aided Verification, 1254:340–51. Springer,
1997. https://doi.org/10.1007/3-540-63166-6_34.
ieee: R. Alur, R. Brayton, T. A. Henzinger, S. Qadeer, and S. Rajamani, “Partial-order
reduction in symbolic state-space exploration,” in 9th International Conference
on Computer Aided Verification, Haifa, Israel, 1997, vol. 1254, pp. 340–351.
ista: 'Alur R, Brayton R, Henzinger TA, Qadeer S, Rajamani S. 1997. Partial-order
reduction in symbolic state-space exploration. 9th International Conference on
Computer Aided Verification. CAV: Computer Aided Verification, LNCS, vol. 1254,
340–351.'
mla: Alur, Rajeev, et al. “Partial-Order Reduction in Symbolic State-Space Exploration.”
9th International Conference on Computer Aided Verification, vol. 1254,
Springer, 1997, pp. 340–51, doi:10.1007/3-540-63166-6_34.
short: R. Alur, R. Brayton, T.A. Henzinger, S. Qadeer, S. Rajamani, in:, 9th International
Conference on Computer Aided Verification, Springer, 1997, pp. 340–351.
conference:
end_date: 1997-06-25
location: Haifa, Israel
name: 'CAV: Computer Aided Verification'
start_date: 1997-06-22
date_created: 2018-12-11T12:09:44Z
date_published: 1997-01-01T00:00:00Z
date_updated: 2022-08-16T14:09:54Z
day: '01'
doi: 10.1007/3-540-63166-6_34
extern: '1'
intvolume: ' 1254'
language:
- iso: eng
month: '01'
oa_version: None
page: 340 - 351
publication: 9th International Conference on Computer Aided Verification
publication_identifier:
isbn:
- '9783540631668'
publication_status: published
publisher: Springer
publist_id: '99'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Partial-order reduction in symbolic state-space exploration
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1254
year: '1997'
...
---
_id: '4609'
abstract:
- lang: eng
text: 'Temporal logic comes in two varieties: linear-time temporal logic assumes
implicit universal quantification over all paths that are generated by system
moves; branching-time temporal logic allows explicit existential and universal
quantification over all paths. We introduce a third, more general variety of temporal
logic: alternating-time temporal logic offers selective quantification over those
paths that are possible outcomes of games, such as the game in which the system
and the environment alternate moves. While linear-time and branching-time logics
are natural specification languages for closed systems, alternating-time logics
are natural specification languages for open systems. For example, by preceding
the temporal operator “eventually” with a selective path quantifier, we can specify
that in the game between the system and the environment, the system has a strategy
to reach a certain state. Also the problems of receptiveness, realizability, and
controllability can be formulated as model-checking problems for alternating-time
formulas'
acknowledgement: We thank Luca de Alfaro, Kousha Etessami, Salvatore La Torre, P.
Madhusudan, Amir Pnueli, Moshe Vardi, Thomas Wilke, and Mihalis Yannakakis for helpful
discussions. We also thank Freddy Mang for comments on a draft of this manuscript.
article_processing_charge: No
author:
- first_name: Rajeev
full_name: Alur, Rajeev
last_name: Alur
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Orna
full_name: Kupferman, Orna
last_name: Kupferman
citation:
ama: 'Alur R, Henzinger TA, Kupferman O. Alternating-time temporal logic. In: Proceedings
of the 38th Annual Symposium on Foundations of Computer Science. Association
for Computing Machinery (ACM); 1997:100-109. doi:10.1145/585265.585270'
apa: 'Alur, R., Henzinger, T. A., & Kupferman, O. (1997). Alternating-time temporal
logic. In Proceedings of the 38th Annual Symposium on Foundations of Computer
Science (pp. 100–109). Washington, DC, United States: Association for Computing
Machinery (ACM). https://doi.org/10.1145/585265.585270'
chicago: Alur, Rajeev, Thomas A Henzinger, and Orna Kupferman. “Alternating-Time
Temporal Logic.” In Proceedings of the 38th Annual Symposium on Foundations
of Computer Science, 100–109. Association for Computing Machinery (ACM), 1997.
https://doi.org/10.1145/585265.585270.
ieee: R. Alur, T. A. Henzinger, and O. Kupferman, “Alternating-time temporal logic,”
in Proceedings of the 38th Annual Symposium on Foundations of Computer Science,
Washington, DC, United States, 1997, pp. 100–109.
ista: 'Alur R, Henzinger TA, Kupferman O. 1997. Alternating-time temporal logic.
Proceedings of the 38th Annual Symposium on Foundations of Computer Science. FOCS:
Foundations of Computer Science, 100–109.'
mla: Alur, Rajeev, et al. “Alternating-Time Temporal Logic.” Proceedings of the
38th Annual Symposium on Foundations of Computer Science, Association for
Computing Machinery (ACM), 1997, pp. 100–09, doi:10.1145/585265.585270.
short: R. Alur, T.A. Henzinger, O. Kupferman, in:, Proceedings of the 38th Annual
Symposium on Foundations of Computer Science, Association for Computing Machinery
(ACM), 1997, pp. 100–109.
conference:
end_date: 1997-10-22
location: Washington, DC, United States
name: 'FOCS: Foundations of Computer Science'
start_date: 1997-10-19
date_created: 2018-12-11T12:09:44Z
date_published: 1997-01-01T00:00:00Z
date_updated: 2022-09-05T07:32:05Z
day: '01'
doi: 10.1145/585265.585270
extern: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 100 - 109
publication: Proceedings of the 38th Annual Symposium on Foundations of Computer Science
publication_identifier:
issn:
- 0004-5411
publication_status: published
publisher: Association for Computing Machinery (ACM)
publist_id: '100'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Alternating-time temporal logic
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '1997'
...
---
_id: '4607'
abstract:
- lang: eng
text: We present a verification algorithm for duration properties of real-time systems.
While simple real-time properties constrain the total elapsed time between events,
duration properties constrain the accumulated satisfaction time of state predicates.
We formalize the concept of durations by introducing duration measures for timed
automata. A duration measure assigns to each finite run of a timed automaton a
real number —the duration of the run— which may be the accumulated satisfaction
time of a state predicate along the run. Given a timed automaton with a duration
measure, an initial and a final state, and an arithmetic constraint, the duration-bounded
reachability problem asks if there is a run of the automaton from the initial
state to the final state such that the duration of the run satisfies the constraint.
Our main result is an (optimal) PSPACE decision procedure for the duration-bounded
reachability problem.
acknowledgement: "A preliminary version of this paper appeared in the Proceedings
of the Fifth International Conference on Computer-Aided Verification (CAV 93), Springer-Verlag
LNCS 818, pp. 181–193, 1993. We thank Sergio Yovine for a careful reading of the
manuscript. This reaserch was partially supported by the BRA ESPRIT project REACT,
by the ONR YIP\r\naward N00014-95-1-0520, by the NSF CAREER award CCR-9501708, by
the NSF grants CCR-9200794 and CCR-9504469, by the AFOSR contract F49620-93-1-0056,
and by the ARPA grant NAG2-892."
article_processing_charge: No
article_type: original
author:
- first_name: Rajeev
full_name: Alur, Rajeev
last_name: Alur
- first_name: Costas
full_name: Courcoubetis, Costas
last_name: Courcoubetis
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
citation:
ama: Alur R, Courcoubetis C, Henzinger TA. Computing accumulated delays in real-time
systems. Formal Methods in System Design. 1997;11(2):137-156. doi:10.1023/A:1008626013578
apa: Alur, R., Courcoubetis, C., & Henzinger, T. A. (1997). Computing accumulated
delays in real-time systems. Formal Methods in System Design. Springer.
https://doi.org/10.1023/A:1008626013578
chicago: Alur, Rajeev, Costas Courcoubetis, and Thomas A Henzinger. “Computing Accumulated
Delays in Real-Time Systems.” Formal Methods in System Design. Springer,
1997. https://doi.org/10.1023/A:1008626013578.
ieee: R. Alur, C. Courcoubetis, and T. A. Henzinger, “Computing accumulated delays
in real-time systems,” Formal Methods in System Design, vol. 11, no. 2.
Springer, pp. 137–156, 1997.
ista: Alur R, Courcoubetis C, Henzinger TA. 1997. Computing accumulated delays in
real-time systems. Formal Methods in System Design. 11(2), 137–156.
mla: Alur, Rajeev, et al. “Computing Accumulated Delays in Real-Time Systems.” Formal
Methods in System Design, vol. 11, no. 2, Springer, 1997, pp. 137–56, doi:10.1023/A:1008626013578.
short: R. Alur, C. Courcoubetis, T.A. Henzinger, Formal Methods in System Design
11 (1997) 137–156.
date_created: 2018-12-11T12:09:43Z
date_published: 1997-01-01T00:00:00Z
date_updated: 2022-08-16T13:43:41Z
day: '01'
doi: 10.1023/A:1008626013578
extern: '1'
intvolume: ' 11'
issue: '2'
language:
- iso: eng
month: '01'
oa_version: None
page: 137 - 156
publication: Formal Methods in System Design
publication_identifier:
issn:
- 0925-9856
publication_status: published
publisher: Springer
publist_id: '98'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Computing accumulated delays in real-time systems
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 11
year: '1997'
...
---
_id: '4605'
abstract:
- lang: eng
text: A hybrid system is a dynamical system whose behavior exhibits both discrete
and continuous change. A hybrid automaton is a mathematical model for hybrid systems,
which combines, in a single formalism, automaton transitions for capturing discrete
change with differential equations for capturing continuous change. In this survey,
we demonstrate symbolic algorithms for the verification of and controller synthesis
for linear hybrid automata, a subclass of hybrid automata that can be analyzed
automatically
article_processing_charge: No
author:
- first_name: Rajeev
full_name: Alur, Rajeev
last_name: Alur
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Howard
full_name: Wong Toi, Howard
last_name: Wong Toi
citation:
ama: 'Alur R, Henzinger TA, Wong Toi H. Symbolic analysis of hybrid systems. In:
Proceedings of the 36th IEEE Conference on Decision and Control. IEEE;
1997:702-707. doi:10.1109/CDC.1997.650717
'
apa: 'Alur, R., Henzinger, T. A., & Wong Toi, H. (1997). Symbolic analysis of
hybrid systems. In Proceedings of the 36th IEEE Conference on Decision and
Control (pp. 702–707). San Diego, CA, USA: IEEE. https://doi.org/10.1109/CDC.1997.650717 '
chicago: Alur, Rajeev, Thomas A Henzinger, and Howard Wong Toi. “Symbolic Analysis
of Hybrid Systems.” In Proceedings of the 36th IEEE Conference on Decision
and Control, 702–7. IEEE, 1997. https://doi.org/10.1109/CDC.1997.650717 .
ieee: R. Alur, T. A. Henzinger, and H. Wong Toi, “Symbolic analysis of hybrid systems,”
in Proceedings of the 36th IEEE Conference on Decision and Control, San
Diego, CA, USA, 1997, pp. 702–707.
ista: 'Alur R, Henzinger TA, Wong Toi H. 1997. Symbolic analysis of hybrid systems.
Proceedings of the 36th IEEE Conference on Decision and Control. CDC: Decision
and Control, 702–707.'
mla: Alur, Rajeev, et al. “Symbolic Analysis of Hybrid Systems.” Proceedings
of the 36th IEEE Conference on Decision and Control, IEEE, 1997, pp. 702–07,
doi:10.1109/CDC.1997.650717
.
short: R. Alur, T.A. Henzinger, H. Wong Toi, in:, Proceedings of the 36th IEEE Conference
on Decision and Control, IEEE, 1997, pp. 702–707.
conference:
end_date: 1997-12-12
location: San Diego, CA, USA
name: 'CDC: Decision and Control'
start_date: 1997-12-12
date_created: 2018-12-11T12:09:43Z
date_published: 1997-12-01T00:00:00Z
date_updated: 2022-08-17T08:08:36Z
day: '01'
doi: '10.1109/CDC.1997.650717 '
extern: '1'
language:
- iso: eng
month: '12'
oa_version: None
page: 702 - 707
publication: Proceedings of the 36th IEEE Conference on Decision and Control
publication_identifier:
isbn:
- '0780341872'
publication_status: published
publisher: IEEE
publist_id: '101'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Symbolic analysis of hybrid systems
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '1997'
...
---
_id: '8528'
abstract:
- lang: eng
text: "In the present paper, we give a definition of prevalent (\"metrically prevalent\"
) sets in nonlinear function\r\nspaces. A subset of a Euclidean space is said
to be metrically prevalent if its complement has measure zero.\r\nThere is no
natural way to generalize the definition of a set of measure zero in a finite-dimensional
space\r\nto the infinite-dimensional case [6]. Therefore, it is necessary to give
a special definition of a metrically\r\nprevalent set (set of full measure) in
an infinite-dimensional space. There are various ways to do so. We\r\nsuggest
one of the possible ways to define the class of metrically prevalent sets in the
space of smooth maps\r\nof one smooth manifold into another. It is shown in this
paper that the class of metrically prevalent sets\r\nhas natural properties; in
particular, the intersection of finitely many metrically prevalent sets is metrically\r\nprevalent.
The main result of the paper is a prevalent version of Thorn's transversality
theorem.\r\nIt is common practice in singularity theory and the theory of dynamical
systems to say that a property\r\nholds for \"almost every\" map (or flow) if
it holds for a residual set, i.e., a set that contains a countable\r\nintersection
of open dense sets in the corresponding function space. However, even in finite-dimensional\r\nspaces
such a set can have arbitrarily small (say, zero) Lebesgue measure. We prove that
Thorn's transversality theorem holds for an essentially \"thicker\" set than a
residual set. It seems reasonable to revise from\r\nthe prevalent point of view
the classical results of singularity theory and theory of dynamical systems,\r\nincluding
the multijet transversality theorem, Mather's stability theorem, Kupka-Smale's
theorem for dynamical systems, etc. We shall do this elsewhere. The notion of
prevalence in linear Banach spaces was\r\nintroduced and investigated in [8].
One of the possible ways to define a class of prevalent sets in the space\r\nof
smooth maps of manifolds, which essentially differs from that presented in this
paper, is given in [7].\r\nDefinitions of typicalness based on the Lebesgue measure
in a finite-dimensional space were suggested\r\nby Kolmogorov [10] and Arnold
[11]. These definitions were cited and discussed in [9]. Here we only point\r\nout
that the finite-dimensional analog of Arnold's definition allows prevalent sets
to have arbitrarily small\r\nmeasure, whereas the prevalent sets in the sense
of the finite-dimensional analog of the definition given in\r\nthe present paper
are necessarily of full measure. Our definition is a modification of that due
to Arnold.\r\nI wish to thank Yu. S. Illyashenko for constant attention to this
work and useful discussions and\r\nR. I. Bogdanov for help in the preparation
of this paper. "
article_processing_charge: No
article_type: original
author:
- first_name: Vadim
full_name: Kaloshin, Vadim
id: FE553552-CDE8-11E9-B324-C0EBE5697425
last_name: Kaloshin
orcid: 0000-0002-6051-2628
citation:
ama: Kaloshin V. Prevalence in the space of finitely smooth maps. Functional
Analysis and Its Applications. 1997;31(2):95-99. doi:10.1007/bf02466014
apa: Kaloshin, V. (1997). Prevalence in the space of finitely smooth maps. Functional
Analysis and Its Applications. Springer Nature. https://doi.org/10.1007/bf02466014
chicago: Kaloshin, Vadim. “Prevalence in the Space of Finitely Smooth Maps.” Functional
Analysis and Its Applications. Springer Nature, 1997. https://doi.org/10.1007/bf02466014.
ieee: V. Kaloshin, “Prevalence in the space of finitely smooth maps,” Functional
Analysis and Its Applications, vol. 31, no. 2. Springer Nature, pp. 95–99,
1997.
ista: Kaloshin V. 1997. Prevalence in the space of finitely smooth maps. Functional
Analysis and Its Applications. 31(2), 95–99.
mla: Kaloshin, Vadim. “Prevalence in the Space of Finitely Smooth Maps.” Functional
Analysis and Its Applications, vol. 31, no. 2, Springer Nature, 1997, pp.
95–99, doi:10.1007/bf02466014.
short: V. Kaloshin, Functional Analysis and Its Applications 31 (1997) 95–99.
date_created: 2020-09-18T10:50:54Z
date_published: 1997-03-30T00:00:00Z
date_updated: 2021-01-12T08:19:54Z
day: '30'
doi: 10.1007/bf02466014
extern: '1'
intvolume: ' 31'
issue: '2'
keyword:
- Applied Mathematics
- Analysis
language:
- iso: eng
month: '03'
oa_version: None
page: 95-99
publication: Functional Analysis and Its Applications
publication_identifier:
issn:
- 0016-2663
- 1573-8485
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Prevalence in the space of finitely smooth maps
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 31
year: '1997'
...
---
_id: '8527'
abstract:
- lang: eng
text: We introduce a new potential-theoretic definition of the dimension spectrum of
a probability measure for q > 1 and explain its relation to prior definitions.
We apply this definition to prove that if and is a Borel probability measure
with compact support in , then under almost every linear transformation from to
, the q-dimension of the image of is ; in particular, the q-dimension of is
preserved provided . We also present results on the preservation of information
dimension and pointwise dimension. Finally, for and q > 2 we give examples for
which is not preserved by any linear transformation into . All results for typical
linear transformations are also proved for typical (in the sense of prevalence)
continuously differentiable functions.
article_processing_charge: No
article_type: original
author:
- first_name: Brian R
full_name: Hunt, Brian R
last_name: Hunt
- first_name: Vadim
full_name: Kaloshin, Vadim
id: FE553552-CDE8-11E9-B324-C0EBE5697425
last_name: Kaloshin
orcid: 0000-0002-6051-2628
citation:
ama: Hunt BR, Kaloshin V. How projections affect the dimension spectrum of fractal
measures. Nonlinearity. 1997;10(5):1031-1046. doi:10.1088/0951-7715/10/5/002
apa: Hunt, B. R., & Kaloshin, V. (1997). How projections affect the dimension
spectrum of fractal measures. Nonlinearity. IOP Publishing. https://doi.org/10.1088/0951-7715/10/5/002
chicago: Hunt, Brian R, and Vadim Kaloshin. “How Projections Affect the Dimension
Spectrum of Fractal Measures.” Nonlinearity. IOP Publishing, 1997. https://doi.org/10.1088/0951-7715/10/5/002.
ieee: B. R. Hunt and V. Kaloshin, “How projections affect the dimension spectrum
of fractal measures,” Nonlinearity, vol. 10, no. 5. IOP Publishing, pp.
1031–1046, 1997.
ista: Hunt BR, Kaloshin V. 1997. How projections affect the dimension spectrum of
fractal measures. Nonlinearity. 10(5), 1031–1046.
mla: Hunt, Brian R., and Vadim Kaloshin. “How Projections Affect the Dimension Spectrum
of Fractal Measures.” Nonlinearity, vol. 10, no. 5, IOP Publishing, 1997,
pp. 1031–46, doi:10.1088/0951-7715/10/5/002.
short: B.R. Hunt, V. Kaloshin, Nonlinearity 10 (1997) 1031–1046.
date_created: 2020-09-18T10:50:41Z
date_published: 1997-06-19T00:00:00Z
date_updated: 2021-01-12T08:19:53Z
day: '19'
doi: 10.1088/0951-7715/10/5/002
extern: '1'
intvolume: ' 10'
issue: '5'
keyword:
- Mathematical Physics
- General Physics and Astronomy
- Applied Mathematics
- Statistical and Nonlinear Physics
language:
- iso: eng
month: '06'
oa_version: None
page: 1031-1046
publication: Nonlinearity
publication_identifier:
issn:
- 0951-7715
- 1361-6544
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
status: public
title: How projections affect the dimension spectrum of fractal measures
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 10
year: '1997'
...