---
_id: '11123'
abstract:
- lang: eng
text: The small GTPase Ran is a key regulator of nucleocytoplasmic transport during
interphase. The asymmetric distribution of the GTP-bound form of Ran across the
nuclear envelope — that is, large quantities in the nucleus compared with small
quantities in the cytoplasm — determines the directionality of many nuclear transport
processes. Recent findings that Ran also functions in spindle formation and nuclear
envelope assembly during mitosis suggest that Ran has a general role in chromatin-centred
processes. Ran functions in these events as a signal for chromosome position.
article_processing_charge: No
article_type: original
author:
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
- first_name: Oliver J.
full_name: Gruss, Oliver J.
last_name: Gruss
- first_name: Iain W.
full_name: Mattaj, Iain W.
last_name: Mattaj
citation:
ama: Hetzer M, Gruss OJ, Mattaj IW. The Ran GTPase as a marker of chromosome position
in spindle formation and nuclear envelope assembly. Nature Cell Biology.
2002;4(7):E177-E184. doi:10.1038/ncb0702-e177
apa: Hetzer, M., Gruss, O. J., & Mattaj, I. W. (2002). The Ran GTPase as a marker
of chromosome position in spindle formation and nuclear envelope assembly. Nature
Cell Biology. Springer Nature. https://doi.org/10.1038/ncb0702-e177
chicago: Hetzer, Martin, Oliver J. Gruss, and Iain W. Mattaj. “The Ran GTPase as
a Marker of Chromosome Position in Spindle Formation and Nuclear Envelope Assembly.”
Nature Cell Biology. Springer Nature, 2002. https://doi.org/10.1038/ncb0702-e177.
ieee: M. Hetzer, O. J. Gruss, and I. W. Mattaj, “The Ran GTPase as a marker of chromosome
position in spindle formation and nuclear envelope assembly,” Nature Cell Biology,
vol. 4, no. 7. Springer Nature, pp. E177–E184, 2002.
ista: Hetzer M, Gruss OJ, Mattaj IW. 2002. The Ran GTPase as a marker of chromosome
position in spindle formation and nuclear envelope assembly. Nature Cell Biology.
4(7), E177–E184.
mla: Hetzer, Martin, et al. “The Ran GTPase as a Marker of Chromosome Position in
Spindle Formation and Nuclear Envelope Assembly.” Nature Cell Biology,
vol. 4, no. 7, Springer Nature, 2002, pp. E177–84, doi:10.1038/ncb0702-e177.
short: M. Hetzer, O.J. Gruss, I.W. Mattaj, Nature Cell Biology 4 (2002) E177–E184.
date_created: 2022-04-07T07:57:19Z
date_published: 2002-07-01T00:00:00Z
date_updated: 2022-07-18T08:58:03Z
day: '01'
doi: 10.1038/ncb0702-e177
extern: '1'
external_id:
pmid:
- '12105431'
intvolume: ' 4'
issue: '7'
keyword:
- Cell Biology
language:
- iso: eng
month: '07'
oa_version: None
page: E177-E184
pmid: 1
publication: Nature Cell Biology
publication_identifier:
eissn:
- 1476-4679
issn:
- 1465-7392
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: The Ran GTPase as a marker of chromosome position in spindle formation and
nuclear envelope assembly
type: journal_article
user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd
volume: 4
year: '2002'
...
---
_id: '11124'
abstract:
- lang: eng
text: Ran GTPase plays important roles in nucleocytoplasmic transport in interphase
[1, 2] and in both spindle formation and nuclear envelope (NE) assembly during
mitosis [3, 4, 5]. The latter functions rely on the presence of high local concentrations
of GTP-bound Ran near mitotic chromatin [3, 4, 5]. RanGTP localization has been
proposed to result from the association of Ran's GDP/GTP exchange factor, RCC1,
with chromatin [6, 7, 8, 9], but Ran is shown here to bind directly to chromatin
in two modes, either dependent or independent of RCC1, and, where bound, to increase
the affinity of chromatin for NE membranes. We propose that the Ran binding capacity
of chromatin contributes to localized spindle and NE assembly.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Daniel
full_name: Bilbao-Cortés, Daniel
last_name: Bilbao-Cortés
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
- first_name: Gernot
full_name: Längst, Gernot
last_name: Längst
- first_name: Peter B.
full_name: Becker, Peter B.
last_name: Becker
- first_name: Iain W.
full_name: Mattaj, Iain W.
last_name: Mattaj
citation:
ama: Bilbao-Cortés D, Hetzer M, Längst G, Becker PB, Mattaj IW. Ran binds to chromatin
by two distinct mechanisms. Current Biology. 2002;12(13):1151-1156. doi:10.1016/s0960-9822(02)00927-2
apa: Bilbao-Cortés, D., Hetzer, M., Längst, G., Becker, P. B., & Mattaj, I.
W. (2002). Ran binds to chromatin by two distinct mechanisms. Current Biology.
Elsevier BV. https://doi.org/10.1016/s0960-9822(02)00927-2
chicago: Bilbao-Cortés, Daniel, Martin Hetzer, Gernot Längst, Peter B. Becker, and
Iain W. Mattaj. “Ran Binds to Chromatin by Two Distinct Mechanisms.” Current
Biology. Elsevier BV, 2002. https://doi.org/10.1016/s0960-9822(02)00927-2.
ieee: D. Bilbao-Cortés, M. Hetzer, G. Längst, P. B. Becker, and I. W. Mattaj, “Ran
binds to chromatin by two distinct mechanisms,” Current Biology, vol. 12,
no. 13. Elsevier BV, pp. 1151–1156, 2002.
ista: Bilbao-Cortés D, Hetzer M, Längst G, Becker PB, Mattaj IW. 2002. Ran binds
to chromatin by two distinct mechanisms. Current Biology. 12(13), 1151–1156.
mla: Bilbao-Cortés, Daniel, et al. “Ran Binds to Chromatin by Two Distinct Mechanisms.”
Current Biology, vol. 12, no. 13, Elsevier BV, 2002, pp. 1151–56, doi:10.1016/s0960-9822(02)00927-2.
short: D. Bilbao-Cortés, M. Hetzer, G. Längst, P.B. Becker, I.W. Mattaj, Current
Biology 12 (2002) 1151–1156.
date_created: 2022-04-07T07:57:31Z
date_published: 2002-07-09T00:00:00Z
date_updated: 2022-07-18T08:58:05Z
day: '09'
doi: 10.1016/s0960-9822(02)00927-2
extern: '1'
external_id:
pmid:
- '12121625'
intvolume: ' 12'
issue: '13'
keyword:
- General Agricultural and Biological Sciences
- General Biochemistry
- Genetics and Molecular Biology
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/S0960-9822(02)00927-2
month: '07'
oa: 1
oa_version: Published Version
page: 1151-1156
pmid: 1
publication: Current Biology
publication_identifier:
issn:
- 0960-9822
publication_status: published
publisher: Elsevier BV
quality_controlled: '1'
scopus_import: '1'
status: public
title: Ran binds to chromatin by two distinct mechanisms
type: journal_article
user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd
volume: 12
year: '2002'
...
---
_id: '2338'
abstract:
- lang: eng
text: Now that the low temperature properties of quantum-mechanical many-body systems
(bosons) at low density, ρ, can be examined experimentally it is appropriate to
revisit some of the formulas deduced by many authors 4-5 decades ago. For systems
with repulsive (i.e. positive) interaction potentials the experimental low temperature
state and the ground state are effectively synonymous -- and this fact is used
in all modeling. In such cases, the leading term in the energy/particle is 2πℏ2aρ/m
where a is the scattering length of the two-body potential. Owing to the delicate
and peculiar nature of bosonic correlations (such as the strange N7/5 law for
charged bosons), four decades of research failed to establish this plausible formula
rigorously. The only previous lower bound for the energy was found by Dyson in
1957, but it was 14 times too small. The correct asymptotic formula has recently
been obtained by us and this work will be presented. The reason behind the mathematical
difficulties will be emphasized. A different formula, postulated as late as 1971
by Schick, holds in two-dimensions and this, too, will be shown to be correct.
With the aid of the methodology developed to prove the lower bound for the homogeneous
gas, two other problems have been successfully addressed. One is the proof by
us that the Gross-Pitaevskii equation correctly describes the ground state in
the `traps' actually used in the experiments. For this system it is also possible
to prove complete Bose condensation, as we have shown. Another topic is a proof
that Foldy's 1961 theory of a high density Bose gas of charged particles correctly
describes its ground state energy.
alternative_title:
- Current Developments in Mathematics
article_processing_charge: No
arxiv: 1
author:
- first_name: Élliott
full_name: Lieb, Élliott
last_name: Lieb
- first_name: Jan
full_name: Solovej, Jan
last_name: Solovej
- first_name: Robert
full_name: Seiringer, Robert
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
- first_name: Jakob
full_name: Yngvason, Jakob
last_name: Yngvason
citation:
ama: 'Lieb É, Solovej J, Seiringer R, Yngvason J. The ground state of the Bose gas.
In: Current Developments in Mathematics, 2001. International Press; 2002:131-178.
doi:10.48550/arXiv.math-ph/0204027'
apa: Lieb, É., Solovej, J., Seiringer, R., & Yngvason, J. (2002). The ground
state of the Bose gas. In Current Developments in Mathematics, 2001 (pp.
131–178). International Press. https://doi.org/10.48550/arXiv.math-ph/0204027
chicago: Lieb, Élliott, Jan Solovej, Robert Seiringer, and Jakob Yngvason. “The
Ground State of the Bose Gas.” In Current Developments in Mathematics, 2001,
131–78. International Press, 2002. https://doi.org/10.48550/arXiv.math-ph/0204027.
ieee: É. Lieb, J. Solovej, R. Seiringer, and J. Yngvason, “The ground state of the
Bose gas,” in Current Developments in Mathematics, 2001, International
Press, 2002, pp. 131–178.
ista: 'Lieb É, Solovej J, Seiringer R, Yngvason J. 2002.The ground state of the
Bose gas. In: Current Developments in Mathematics, 2001. Current Developments
in Mathematics, , 131–178.'
mla: Lieb, Élliott, et al. “The Ground State of the Bose Gas.” Current Developments
in Mathematics, 2001, International Press, 2002, pp. 131–78, doi:10.48550/arXiv.math-ph/0204027.
short: É. Lieb, J. Solovej, R. Seiringer, J. Yngvason, in:, Current Developments
in Mathematics, 2001, International Press, 2002, pp. 131–178.
date_created: 2018-12-11T11:57:04Z
date_published: 2002-01-01T00:00:00Z
date_updated: 2023-07-26T08:43:46Z
day: '01'
doi: 10.48550/arXiv.math-ph/0204027
extern: '1'
external_id:
arxiv:
- math-ph/0204027
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/math-ph/0204027
month: '01'
oa: 1
oa_version: Published Version
page: 131 - 178
publication: Current Developments in Mathematics, 2001
publication_identifier:
isbn:
- '9781571461018'
publication_status: published
publisher: International Press
publist_id: '4588'
status: public
title: The ground state of the Bose gas
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '2002'
...
---
_id: '2339'
alternative_title:
- Contemporary Mathematics
author:
- first_name: Robert
full_name: Robert Seiringer
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
citation:
ama: 'Seiringer R. Symmetry breaking in a model of a rotating Bose gas. In: Weder
R, Exner P, Grébert B, eds. Vol 307. World Scientific Publishing; 2002:281-286.
doi:10.1090/conm/307'
apa: 'Seiringer, R. (2002). Symmetry breaking in a model of a rotating Bose gas.
In R. Weder, P. Exner, & B. Grébert (Eds.) (Vol. 307, pp. 281–286). Presented
at the QMath: Mathematical Results in Quantum Physics, World Scientific Publishing.
https://doi.org/10.1090/conm/307'
chicago: Seiringer, Robert. “Symmetry Breaking in a Model of a Rotating Bose Gas.”
edited by Richardo Weder, Pavel Exner, and Benoit Grébert, 307:281–86. World Scientific
Publishing, 2002. https://doi.org/10.1090/conm/307.
ieee: 'R. Seiringer, “Symmetry breaking in a model of a rotating Bose gas,” presented
at the QMath: Mathematical Results in Quantum Physics, 2002, vol. 307, pp. 281–286.'
ista: 'Seiringer R. 2002. Symmetry breaking in a model of a rotating Bose gas. QMath:
Mathematical Results in Quantum Physics, Contemporary Mathematics, vol. 307, 281–286.'
mla: Seiringer, Robert. Symmetry Breaking in a Model of a Rotating Bose Gas.
Edited by Richardo Weder et al., vol. 307, World Scientific Publishing, 2002,
pp. 281–86, doi:10.1090/conm/307.
short: R. Seiringer, in:, R. Weder, P. Exner, B. Grébert (Eds.), World Scientific
Publishing, 2002, pp. 281–286.
conference:
name: 'QMath: Mathematical Results in Quantum Physics'
date_created: 2018-12-11T11:57:05Z
date_published: 2002-01-01T00:00:00Z
date_updated: 2021-01-12T06:56:53Z
day: '01'
doi: 10.1090/conm/307
editor:
- first_name: Richardo
full_name: Weder, Richardo
last_name: Weder
- first_name: Pavel
full_name: Exner, Pavel
last_name: Exner
- first_name: Benoit
full_name: Grébert, Benoit
last_name: Grébert
extern: 1
intvolume: ' 307'
month: '01'
page: 281 - 286
publication_status: published
publisher: World Scientific Publishing
publist_id: '4587'
quality_controlled: 0
status: public
title: Symmetry breaking in a model of a rotating Bose gas
type: conference
volume: 307
year: '2002'
...
---
_id: '2349'
abstract:
- lang: eng
text: The Bose-Einstein condensation (BEC) of the ground state of bosonic atoms
in a trap was discussed. The BEC was proved for bosons with two-body repulsive
interaction potentials in the dilute limit, starting from the basic Schrodinger
equation. The BEC was 100% into the state which minimized the Gross-Pitaevskii
energy functional. The analysis also included rigorous proof of BEC in a physically
realistic, continuum model.
author:
- first_name: Élliott
full_name: Lieb, Élliott H
last_name: Lieb
- first_name: Robert
full_name: Robert Seiringer
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
citation:
ama: Lieb É, Seiringer R. Proof of Bose-Einstein condensation for dilute trapped
gases. Physical Review Letters. 2002;88(17):1704091-1704094. doi:10.1103/PhysRevLett.88.170409
apa: Lieb, É., & Seiringer, R. (2002). Proof of Bose-Einstein condensation for
dilute trapped gases. Physical Review Letters. American Physical Society.
https://doi.org/10.1103/PhysRevLett.88.170409
chicago: Lieb, Élliott, and Robert Seiringer. “Proof of Bose-Einstein Condensation
for Dilute Trapped Gases.” Physical Review Letters. American Physical Society,
2002. https://doi.org/10.1103/PhysRevLett.88.170409.
ieee: É. Lieb and R. Seiringer, “Proof of Bose-Einstein condensation for dilute
trapped gases,” Physical Review Letters, vol. 88, no. 17. American Physical
Society, pp. 1704091–1704094, 2002.
ista: Lieb É, Seiringer R. 2002. Proof of Bose-Einstein condensation for dilute
trapped gases. Physical Review Letters. 88(17), 1704091–1704094.
mla: Lieb, Élliott, and Robert Seiringer. “Proof of Bose-Einstein Condensation for
Dilute Trapped Gases.” Physical Review Letters, vol. 88, no. 17, American
Physical Society, 2002, pp. 1704091–94, doi:10.1103/PhysRevLett.88.170409.
short: É. Lieb, R. Seiringer, Physical Review Letters 88 (2002) 1704091–1704094.
date_created: 2018-12-11T11:57:08Z
date_published: 2002-04-29T00:00:00Z
date_updated: 2021-01-12T06:56:56Z
day: '29'
doi: 10.1103/PhysRevLett.88.170409
extern: 1
intvolume: ' 88'
issue: '17'
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/math-ph/0112032
month: '04'
oa: 1
page: 1704091 - 1704094
publication: Physical Review Letters
publication_status: published
publisher: American Physical Society
publist_id: '4577'
quality_controlled: 0
status: public
title: Proof of Bose-Einstein condensation for dilute trapped gases
type: journal_article
volume: 88
year: '2002'
...
---
_id: '2350'
abstract:
- lang: eng
text: Using the Pauli-Fierz model of non-relativistic quantum electrodynamics, we
calculate the binding energy of an electron in the field of a nucleus of charge
Z and in presence of the quantized radiation field. We consider the case of small
coupling constant α, but fixed Zα and ultraviolet cut-off Λ. We prove that after
renormalizing the mass the binding energy has, to leading order in α, a finite
limit as Λ goes to infinity; i.e., the cut-off can be removed. The expression
for the ground state energy shift thus obtained agrees with Bethe's formula for
small values of Zα, but shows a different behavior for bigger values.
acknowledgement: "We are grateful to Elliott Lieb for helpful discussions. C.H. was
supported by a Marie Curie Fellowship of the European Community programme “Improving
Human Research Potential and the Socioeconomic Knowledge Base” under contract number
HPMFCT-2000-00660 and by the Deutsche Forschungsgemeinschaft, and acknowledges kind
hospitality at Princeton University, where part of this work was done. R.S. was
supported by the Austrian Science Fund in the form of an Erwin Schrödinger Fellowship.\r\n"
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Christian
full_name: Hainzl, Christian
last_name: Hainzl
- first_name: Robert
full_name: Seiringer, Robert
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
citation:
ama: Hainzl C, Seiringer R. Mass renormalization and energy level shift in non-relativistic
QED. Advances in Theoretical and Mathematical Physics. 2002;6(5):847-871.
doi:10.4310/ATMP.2002.v6.n5.a3
apa: Hainzl, C., & Seiringer, R. (2002). Mass renormalization and energy level
shift in non-relativistic QED. Advances in Theoretical and Mathematical Physics.
International Press. https://doi.org/10.4310/ATMP.2002.v6.n5.a3
chicago: Hainzl, Christian, and Robert Seiringer. “Mass Renormalization and Energy
Level Shift in Non-Relativistic QED.” Advances in Theoretical and Mathematical
Physics. International Press, 2002. https://doi.org/10.4310/ATMP.2002.v6.n5.a3.
ieee: C. Hainzl and R. Seiringer, “Mass renormalization and energy level shift in
non-relativistic QED,” Advances in Theoretical and Mathematical Physics,
vol. 6, no. 5. International Press, pp. 847–871, 2002.
ista: Hainzl C, Seiringer R. 2002. Mass renormalization and energy level shift in
non-relativistic QED. Advances in Theoretical and Mathematical Physics. 6(5),
847–871.
mla: Hainzl, Christian, and Robert Seiringer. “Mass Renormalization and Energy Level
Shift in Non-Relativistic QED.” Advances in Theoretical and Mathematical Physics,
vol. 6, no. 5, International Press, 2002, pp. 847–71, doi:10.4310/ATMP.2002.v6.n5.a3.
short: C. Hainzl, R. Seiringer, Advances in Theoretical and Mathematical Physics
6 (2002) 847–871.
date_created: 2018-12-11T11:57:09Z
date_published: 2002-09-01T00:00:00Z
date_updated: 2023-07-26T08:29:28Z
day: '01'
doi: 10.4310/ATMP.2002.v6.n5.a3
extern: '1'
external_id:
arxiv:
- math-ph/0205044v3
intvolume: ' 6'
issue: '5'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/math-ph/0205044
month: '09'
oa: 1
oa_version: Published Version
page: 847 - 871
publication: Advances in Theoretical and Mathematical Physics
publication_identifier:
issn:
- 1095-0761
publication_status: published
publisher: International Press
publist_id: '4574'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mass renormalization and energy level shift in non-relativistic QED
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 6
year: '2002'
...
---
_id: '2351'
abstract:
- lang: eng
text: We study the Gross-Pitaevskii functional for a rotating two-dimensional Bose
gas in a trap. We prove that there is a breaking of the rotational symmetry in
the ground state; more precisely, for any value of the angular velocity and for
large enough values of the interaction strength, the ground state of the functional
is not an eigenfunction of the angular momentum. This has interesting consequences
on the Bose gas with spin; in particular, the ground state energy depends non-trivially
on the number of spin components, and the different components do not have the
same wave function. For the special case of a harmonic trap potential, we give
explicit upper and lower bounds on the critical coupling constant for symmetry
breaking.
author:
- first_name: Robert
full_name: Robert Seiringer
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
citation:
ama: Seiringer R. Gross-Pitaevskii theory of the rotating Bose gas. Communications
in Mathematical Physics. 2002;229(3):491-509. doi:10.1007/s00220-002-0695-2
apa: Seiringer, R. (2002). Gross-Pitaevskii theory of the rotating Bose gas. Communications
in Mathematical Physics. Springer. https://doi.org/10.1007/s00220-002-0695-2
chicago: Seiringer, Robert. “Gross-Pitaevskii Theory of the Rotating Bose Gas.”
Communications in Mathematical Physics. Springer, 2002. https://doi.org/10.1007/s00220-002-0695-2.
ieee: R. Seiringer, “Gross-Pitaevskii theory of the rotating Bose gas,” Communications
in Mathematical Physics, vol. 229, no. 3. Springer, pp. 491–509, 2002.
ista: Seiringer R. 2002. Gross-Pitaevskii theory of the rotating Bose gas. Communications
in Mathematical Physics. 229(3), 491–509.
mla: Seiringer, Robert. “Gross-Pitaevskii Theory of the Rotating Bose Gas.” Communications
in Mathematical Physics, vol. 229, no. 3, Springer, 2002, pp. 491–509, doi:10.1007/s00220-002-0695-2.
short: R. Seiringer, Communications in Mathematical Physics 229 (2002) 491–509.
date_created: 2018-12-11T11:57:09Z
date_published: 2002-09-01T00:00:00Z
date_updated: 2021-01-12T06:56:57Z
day: '01'
doi: 10.1007/s00220-002-0695-2
extern: 1
intvolume: ' 229'
issue: '3'
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/math-ph/0110010
month: '09'
oa: 1
page: 491 - 509
publication: Communications in Mathematical Physics
publication_status: published
publisher: Springer
publist_id: '4575'
quality_controlled: 0
status: public
title: Gross-Pitaevskii theory of the rotating Bose gas
type: journal_article
volume: 229
year: '2002'
...
---
_id: '2352'
abstract:
- lang: eng
text: We present a generalization of the Fefferman-de la Llave decomposition of
the Coulomb potential to quite arbitrary radial functions V on ℝn going to zero
at infinity. This generalized decomposition can be used to extend previous results
on N-body quantum systems with Coulomb interaction to a more general class of
interactions. As an example of such an application, we derive the high density
asymptotics of the ground state energy of jellium with Yukawa interaction in the
thermodynamic limit, using a correlation estimate by Graf and Solovej.
author:
- first_name: Christian
full_name: Hainzl, Christian
last_name: Hainzl
- first_name: Robert
full_name: Robert Seiringer
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
citation:
ama: Hainzl C, Seiringer R. General decomposition of radial functions on ℝn and
applications to N-body quantum systems. Letters in Mathematical Physics.
2002;61(1):75-84. doi:10.1023/A:1020204818938
apa: Hainzl, C., & Seiringer, R. (2002). General decomposition of radial functions
on ℝn and applications to N-body quantum systems. Letters in Mathematical Physics.
Springer. https://doi.org/10.1023/A:1020204818938
chicago: Hainzl, Christian, and Robert Seiringer. “General Decomposition of Radial
Functions on ℝn and Applications to N-Body Quantum Systems.” Letters in Mathematical
Physics. Springer, 2002. https://doi.org/10.1023/A:1020204818938.
ieee: C. Hainzl and R. Seiringer, “General decomposition of radial functions on
ℝn and applications to N-body quantum systems,” Letters in Mathematical Physics,
vol. 61, no. 1. Springer, pp. 75–84, 2002.
ista: Hainzl C, Seiringer R. 2002. General decomposition of radial functions on
ℝn and applications to N-body quantum systems. Letters in Mathematical Physics.
61(1), 75–84.
mla: Hainzl, Christian, and Robert Seiringer. “General Decomposition of Radial Functions
on ℝn and Applications to N-Body Quantum Systems.” Letters in Mathematical
Physics, vol. 61, no. 1, Springer, 2002, pp. 75–84, doi:10.1023/A:1020204818938.
short: C. Hainzl, R. Seiringer, Letters in Mathematical Physics 61 (2002) 75–84.
date_created: 2018-12-11T11:57:09Z
date_published: 2002-07-01T00:00:00Z
date_updated: 2021-01-12T06:56:58Z
day: '01'
doi: 10.1023/A:1020204818938
extern: 1
intvolume: ' 61'
issue: '1'
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/math-ph/0107011
month: '07'
oa: 1
page: 75 - 84
publication: Letters in Mathematical Physics
publication_status: published
publisher: Springer
publist_id: '4576'
quality_controlled: 0
status: public
title: General decomposition of radial functions on ℝn and applications to N-body
quantum systems
type: journal_article
volume: 61
year: '2002'
...
---
_id: '2353'
abstract:
- lang: eng
text: A commonly used theoretical definition of superfluidity in the ground state
of a Bose gas is based on the response of the system to an imposed velocity field
or, equivalently, to twisted boundary conditions in a box. We are able to carry
out this program in the case of a dilute interacting Bose gas in a trap, and we
prove that a gas with repulsive interactions is 100% superfluid in the dilute
limit in which the Gross-Pitaevskii equation is exact. This is the first example
in an experimentally realistic continuum model in which superfluidity is rigorously
verified.
acknowledgement: E.H.L. was partially supported by the U.S. National Science Foundation,
Grant No. PHY 98-20650. R.S. was supported by the Austrian Science Fund in the from
of an Erwin Schrödinger fellowship.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Élliott
full_name: Lieb, Élliott
last_name: Lieb
- first_name: Robert
full_name: Seiringer, Robert
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
- first_name: Jakob
full_name: Yngvason, Jakob
last_name: Yngvason
citation:
ama: Lieb É, Seiringer R, Yngvason J. Superfluidity in dilute trapped Bose gases.
Physical Review B - Condensed Matter and Materials Physics. 2002;66(13).
doi:10.1103/PhysRevB.66.134529
apa: Lieb, É., Seiringer, R., & Yngvason, J. (2002). Superfluidity in dilute
trapped Bose gases. Physical Review B - Condensed Matter and Materials Physics.
American Physical Society. https://doi.org/10.1103/PhysRevB.66.134529
chicago: Lieb, Élliott, Robert Seiringer, and Jakob Yngvason. “Superfluidity in
Dilute Trapped Bose Gases.” Physical Review B - Condensed Matter and Materials
Physics. American Physical Society, 2002. https://doi.org/10.1103/PhysRevB.66.134529.
ieee: É. Lieb, R. Seiringer, and J. Yngvason, “Superfluidity in dilute trapped Bose
gases,” Physical Review B - Condensed Matter and Materials Physics, vol.
66, no. 13. American Physical Society, 2002.
ista: Lieb É, Seiringer R, Yngvason J. 2002. Superfluidity in dilute trapped Bose
gases. Physical Review B - Condensed Matter and Materials Physics. 66(13).
mla: Lieb, Élliott, et al. “Superfluidity in Dilute Trapped Bose Gases.” Physical
Review B - Condensed Matter and Materials Physics, vol. 66, no. 13, American
Physical Society, 2002, doi:10.1103/PhysRevB.66.134529.
short: É. Lieb, R. Seiringer, J. Yngvason, Physical Review B - Condensed Matter
and Materials Physics 66 (2002).
date_created: 2018-12-11T11:57:10Z
date_published: 2002-10-01T00:00:00Z
date_updated: 2023-07-25T12:05:47Z
day: '01'
doi: 10.1103/PhysRevB.66.134529
extern: '1'
external_id:
arxiv:
- cond-mat/0205570
intvolume: ' 66'
issue: '13'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/cond-mat/0205570
month: '10'
oa: 1
oa_version: None
publication: Physical Review B - Condensed Matter and Materials Physics
publication_identifier:
issn:
- 0163-1829
publication_status: published
publisher: American Physical Society
publist_id: '4573'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Superfluidity in dilute trapped Bose gases
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 66
year: '2002'
...
---
_id: '2420'
abstract:
- lang: eng
text: 'A corner cut in dimension d is a finite subset of N0d that can be separated
from its complement in N0d by an affine hyperplane disjoint from N0d. Corner cuts
were first investigated by Onn and Sturmfels [Adv. Appl. Math. 23 (1999) 29-48],
their original motivation stemmed from computational commutative algebra. Let
us write (Nd0k)cut for the set of corner cuts of cardinality k; in the computational
geometer''s terminology, these are the k-sets of N0d. Among other things, Onn
and Sturmfels give an upper bound of O(k2d(d-1)/(d+1)) for the size of (Nd0k)cut
when the dimension is fixed. In two dimensions, it is known (see [Corteel et al.,
Adv. Appl. Math. 23 (1) (1999) 49-53]) that #(Nd0k)cut = Θ(k log k). We will see
that in general, for any fixed dimension d, the order of magnitude of #(Nd0k)cut
is between kd-1 log k and (k log k)d-1. (It has been communicated to me that the
same bounds have been found independently by G. Rémond.) In fact, the elements
of (Nd0k)cut correspond to the vertices of a certain polytope, and what our proof
shows is that the above upper bound holds for the total number of flags of that
polytope.'
acknowledgement: "I first learned about corner cuts in a seminar talk in which Artur
Andrzejak\r\npresented the results from [6]. My work was initiated by that presentation
and\r\nby the discussions that followed it. I also thank Komei Fukuda, Ingo Schurr,
and\r\nEmo Welzl for helpful comments and discussions."
article_processing_charge: No
article_type: original
author:
- first_name: Uli
full_name: Wagner, Uli
id: 36690CA2-F248-11E8-B48F-1D18A9856A87
last_name: Wagner
orcid: 0000-0002-1494-0568
citation:
ama: Wagner U. On the number of corner cuts. Advances in Applied Mathematics.
2002;29(2):152-161. doi:10.1016/S0196-8858(02)00014-3
apa: Wagner, U. (2002). On the number of corner cuts. Advances in Applied Mathematics.
ACM. https://doi.org/10.1016/S0196-8858(02)00014-3
chicago: Wagner, Uli. “On the Number of Corner Cuts.” Advances in Applied Mathematics.
ACM, 2002. https://doi.org/10.1016/S0196-8858(02)00014-3.
ieee: U. Wagner, “On the number of corner cuts,” Advances in Applied Mathematics,
vol. 29, no. 2. ACM, pp. 152–161, 2002.
ista: Wagner U. 2002. On the number of corner cuts. Advances in Applied Mathematics.
29(2), 152–161.
mla: Wagner, Uli. “On the Number of Corner Cuts.” Advances in Applied Mathematics,
vol. 29, no. 2, ACM, 2002, pp. 152–61, doi:10.1016/S0196-8858(02)00014-3.
short: U. Wagner, Advances in Applied Mathematics 29 (2002) 152–161.
date_created: 2018-12-11T11:57:33Z
date_published: 2002-08-01T00:00:00Z
date_updated: 2023-07-25T11:55:42Z
day: '01'
doi: 10.1016/S0196-8858(02)00014-3
extern: '1'
intvolume: ' 29'
issue: '2'
language:
- iso: eng
month: '08'
oa_version: None
page: 152 - 161
publication: Advances in Applied Mathematics
publication_identifier:
issn:
- 0196-8858
publication_status: published
publisher: ACM
publist_id: '4505'
quality_controlled: '1'
scopus_import: '1'
status: public
title: On the number of corner cuts
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 29
year: '2002'
...
---
_id: '2421'
abstract:
- lang: eng
text: Intersection graphs of disks and of line segments, respectively, have been
well studied, because of both, practical applications and theoretically interesting
properties of these graphs. Despite partial results, the complexity status of
the Clique problem for these two graph classes is still open. Here, we consider
the Clique problem for intersection graphs of ellipses which in a sense, interpolate
between disc and ellipses, and show that it is APX-hard in that case. Moreover,
this holds even if for all ellipses, the ratio of the larger over the smaller
radius is some prescribed number. To our knowledge, this is the first hardness
result for the Clique problem in intersection graphs of objects with finite description
complexity. We also describe a simple approximation algorithm for the case of
ellipses for which the ratio of radii is bounded.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Christoph
full_name: Ambühl, Christoph
last_name: Ambühl
- first_name: Uli
full_name: Wagner, Uli
id: 36690CA2-F248-11E8-B48F-1D18A9856A87
last_name: Wagner
orcid: 0000-0002-1494-0568
citation:
ama: 'Ambühl C, Wagner U. On the Clique problem in intersection graphs of ellipses.
In: Proceedings of the 13th International Symposium on Algorithms and Computation.
Vol 2518. Springer; 2002:489-500. doi:10.1007/3-540-36136-7_43'
apa: 'Ambühl, C., & Wagner, U. (2002). On the Clique problem in intersection
graphs of ellipses. In Proceedings of the 13th International Symposium on Algorithms
and Computation (Vol. 2518, pp. 489–500). Vancouver, Canada: Springer. https://doi.org/10.1007/3-540-36136-7_43'
chicago: Ambühl, Christoph, and Uli Wagner. “On the Clique Problem in Intersection
Graphs of Ellipses.” In Proceedings of the 13th International Symposium on
Algorithms and Computation, 2518:489–500. Springer, 2002. https://doi.org/10.1007/3-540-36136-7_43.
ieee: C. Ambühl and U. Wagner, “On the Clique problem in intersection graphs of
ellipses,” in Proceedings of the 13th International Symposium on Algorithms
and Computation, Vancouver, Canada, 2002, vol. 2518, pp. 489–500.
ista: 'Ambühl C, Wagner U. 2002. On the Clique problem in intersection graphs of
ellipses. Proceedings of the 13th International Symposium on Algorithms and Computation.
ISAAC: International Symposium on Algorithms and Computation, LNCS, vol. 2518,
489–500.'
mla: Ambühl, Christoph, and Uli Wagner. “On the Clique Problem in Intersection Graphs
of Ellipses.” Proceedings of the 13th International Symposium on Algorithms
and Computation, vol. 2518, Springer, 2002, pp. 489–500, doi:10.1007/3-540-36136-7_43.
short: C. Ambühl, U. Wagner, in:, Proceedings of the 13th International Symposium
on Algorithms and Computation, Springer, 2002, pp. 489–500.
conference:
end_date: 2002-11-23
location: Vancouver, Canada
name: 'ISAAC: International Symposium on Algorithms and Computation'
start_date: 2002-11-21
date_created: 2018-12-11T11:57:34Z
date_published: 2002-01-01T00:00:00Z
date_updated: 2023-07-25T11:48:36Z
day: '01'
doi: 10.1007/3-540-36136-7_43
extern: '1'
intvolume: ' 2518'
language:
- iso: eng
month: '01'
oa_version: None
page: 489 - 500
publication: Proceedings of the 13th International Symposium on Algorithms and Computation
publication_identifier:
isbn:
- '9783540001423'
publication_status: published
publisher: Springer
publist_id: '4504'
quality_controlled: '1'
scopus_import: '1'
status: public
title: On the Clique problem in intersection graphs of ellipses
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 2518
year: '2002'
...
---
_id: '2613'
abstract:
- lang: eng
text: In this investigation, we report identification and characterization of a
95 kDa postsynaptic density protein (PSD-95)/discs-large/ ZO-1 (PDZ) domain-containing
protein termed tamalin, also recently named GRP1-associated scaffold protein (GRASP),
that interacts with group 1 metabotropic glutamate receptors (mGluRs). The yeast
two-hybrid system and in vitro pull-down assays indicated that the PDZ domain-containing,
amino-terminal half of tamalin directly binds to the class I PDZ-binding motif
of group 1 mGluRs. The C-terminal half of tamalin also bound to cytohesins, the
members of guanine nucleotide exchange factors (GEFs) specific for the ADP-ribosylation
factor (ARF) family of small GTP-binding proteins. Tamalin mRNA is expressed predominantly
in the telencephalic region and highly overlaps with the expression of group 1
mGluR mRNAs. Both tamalin and cytohesin-2 were enriched and codistributed with
mGluR1a in postsynaptic membrane fractions. Importantly, recombinant and native
mGluR1a/tamalin/cytohesin-2 complexes were coimmunoprecipitated from transfected
COS-7 cells and rat brain tissue, respectively. Transfection of tamalin and mutant
tamalin lacking a cytohesin-binding domain caused an increase and decrease in
cell-surface expression of mGluR1a in COS-7 cells, respectively. Furthermore,
adenovirus-mediated expression of tamalin and dominant-negative tamalin facilitated
and reduced the neuritic distribution of endogenous mGluR5 in cultured hippocampal
neurons, respectively. The results indicate that tamalin plays a key role in the
association of group 1 mGluRs with the ARF-specific GEF proteins and contributes
to intracellular trafficking and the macromolecular organization of group 1 mGluRs
at synapses.
acknowledgement: This work was supported in part by research grants from the Ministry
of Education, Science and Culture of Japan. We thank Bert Vogelstein for providing
adenoviral recombination vectors and Haruhiko Bito for a gift of the enolase promoter
and technical advice. We are grateful to Atsushi Nishimune and Satoshi Kaneko for
technical advice and Kumlesh K. Dev for careful reading of this manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Jun
full_name: Kitano, Jun
last_name: Kitano
- first_name: Kouji
full_name: Kimura, Kouji
last_name: Kimura
- first_name: Yoshimitsu
full_name: Yamazaki, Yoshimitsu
last_name: Yamazaki
- first_name: Takeshi
full_name: Soda, Takeshi
last_name: Soda
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Yoshiaki
full_name: Nakajima, Yoshiaki
last_name: Nakajima
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
citation:
ama: Kitano J, Kimura K, Yamazaki Y, et al. Tamalin, a PDZ domain-containing protein,
links a protein complex formation of group 1 metabotropic glutamate receptors
and the guanine nucleotide exchange factor cytohesins. Journal of Neuroscience.
2002;22(4):1280-1289. doi:10.1523/JNEUROSCI.22-04-01280.2002
apa: Kitano, J., Kimura, K., Yamazaki, Y., Soda, T., Shigemoto, R., Nakajima, Y.,
& Nakanishi, S. (2002). Tamalin, a PDZ domain-containing protein, links a
protein complex formation of group 1 metabotropic glutamate receptors and the
guanine nucleotide exchange factor cytohesins. Journal of Neuroscience.
Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.22-04-01280.2002
chicago: Kitano, Jun, Kouji Kimura, Yoshimitsu Yamazaki, Takeshi Soda, Ryuichi Shigemoto,
Yoshiaki Nakajima, and Shigetada Nakanishi. “Tamalin, a PDZ Domain-Containing
Protein, Links a Protein Complex Formation of Group 1 Metabotropic Glutamate Receptors
and the Guanine Nucleotide Exchange Factor Cytohesins.” Journal of Neuroscience.
Society for Neuroscience, 2002. https://doi.org/10.1523/JNEUROSCI.22-04-01280.2002.
ieee: J. Kitano et al., “Tamalin, a PDZ domain-containing protein, links
a protein complex formation of group 1 metabotropic glutamate receptors and the
guanine nucleotide exchange factor cytohesins,” Journal of Neuroscience,
vol. 22, no. 4. Society for Neuroscience, pp. 1280–1289, 2002.
ista: Kitano J, Kimura K, Yamazaki Y, Soda T, Shigemoto R, Nakajima Y, Nakanishi
S. 2002. Tamalin, a PDZ domain-containing protein, links a protein complex formation
of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange
factor cytohesins. Journal of Neuroscience. 22(4), 1280–1289.
mla: Kitano, Jun, et al. “Tamalin, a PDZ Domain-Containing Protein, Links a Protein
Complex Formation of Group 1 Metabotropic Glutamate Receptors and the Guanine
Nucleotide Exchange Factor Cytohesins.” Journal of Neuroscience, vol. 22,
no. 4, Society for Neuroscience, 2002, pp. 1280–89, doi:10.1523/JNEUROSCI.22-04-01280.2002.
short: J. Kitano, K. Kimura, Y. Yamazaki, T. Soda, R. Shigemoto, Y. Nakajima, S.
Nakanishi, Journal of Neuroscience 22 (2002) 1280–1289.
date_created: 2018-12-11T11:58:40Z
date_published: 2002-02-15T00:00:00Z
date_updated: 2023-07-25T11:34:46Z
day: '15'
doi: 10.1523/JNEUROSCI.22-04-01280.2002
extern: '1'
external_id:
pmid:
- '11850456'
intvolume: ' 22'
issue: '4'
language:
- iso: eng
month: '02'
oa_version: None
page: 1280 - 1289
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '4285'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Tamalin, a PDZ domain-containing protein, links a protein complex formation
of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange
factor cytohesins
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 22
year: '2002'
...
---
_id: '2614'
abstract:
- lang: eng
text: Metabotropic glutamate receptors (mGluRs) from group III reduce glutamate
release. Because these receptors reduce cAMP levels, we explored whether this
signaling pathway contributes to release inhibition caused by mGluRs with low
affinity for L-2-amino-4-phosphonobutyrate (L-AP4). In biochemical experiments
with the population of cerebrocortical nerve terminals we find that L-AP4 (1 mM)
inhibited the Ca2+dependent-evoked release of glutamate by 25%. This inhibitory
effect was largely prevented by the pertussis toxin but was insensitive to inhibitors
of protein kinase C bisindolylmaleimide and protein kinase A H-89. Furthermore,
this inhibition was associated with reduction in N-type Ca2+ channel activity
in the absence of any detectable change in cAMP levels. In the presence of forskolin,
however, L-AP4 decreased the levels of cAMP. The activation of this additional
signaling pathway was very efficient in counteracting the facilitation of glutamate
release induced either by forskolin or the β-adrenergic receptor agonist isoproterenol.
Imaging experiments to measure Ca2+ dynamics in single nerve terminals showed
that L-AP4 strongly reduced the Ca2+ response in 28% of the nerve terminals. Moreover,
immunochemical experiments showed that 25-35% of the nerve terminals that were
immunopositive to synaptophysin were also immunoreactive to the low affinity L-AP4-sensitive
mGluR7. Then, mGluR7 mediates the inhibition of glutamate release caused by 1
mM L-AP4, primarily by a strong inhibition of Ca2+ channels, although high cAMP
uncovers the receptor ability to decrease cAMP.
acknowledgement: We thank Dr. Enrique Castro from Las Palmas University for critical
reading of the manuscript and M. Sefton for editorial assistance.
article_processing_charge: No
article_type: original
author:
- first_name: Carmelo
full_name: Millán, Carmelo
last_name: Millán
- first_name: Rafael
full_name: Luján, Rafael
last_name: Luján
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: José
full_name: Sánchez Prieto, José
last_name: Sánchez Prieto
citation:
ama: Millán C, Luján R, Shigemoto R, Sánchez Prieto J. The inhibition of glutamate
release by metabotropic glutamate receptor 7 affects both [Ca2+]c and cAMP. Evidence
for a strong reduction of Ca2+ entry in single nerve terminals. Journal of
Biological Chemistry. 2002;277(16):14092-14101. doi:10.1074/jbc.M109044200
apa: Millán, C., Luján, R., Shigemoto, R., & Sánchez Prieto, J. (2002). The
inhibition of glutamate release by metabotropic glutamate receptor 7 affects both
[Ca2+]c and cAMP. Evidence for a strong reduction of Ca2+ entry in single nerve
terminals. Journal of Biological Chemistry. American Society for Biochemistry
and Molecular Biology. https://doi.org/10.1074/jbc.M109044200
chicago: Millán, Carmelo, Rafael Luján, Ryuichi Shigemoto, and José Sánchez Prieto.
“The Inhibition of Glutamate Release by Metabotropic Glutamate Receptor 7 Affects
Both [Ca2+]c and CAMP. Evidence for a Strong Reduction of Ca2+ Entry in Single
Nerve Terminals.” Journal of Biological Chemistry. American Society for
Biochemistry and Molecular Biology, 2002. https://doi.org/10.1074/jbc.M109044200.
ieee: C. Millán, R. Luján, R. Shigemoto, and J. Sánchez Prieto, “The inhibition
of glutamate release by metabotropic glutamate receptor 7 affects both [Ca2+]c
and cAMP. Evidence for a strong reduction of Ca2+ entry in single nerve terminals,”
Journal of Biological Chemistry, vol. 277, no. 16. American Society for
Biochemistry and Molecular Biology, pp. 14092–14101, 2002.
ista: Millán C, Luján R, Shigemoto R, Sánchez Prieto J. 2002. The inhibition of
glutamate release by metabotropic glutamate receptor 7 affects both [Ca2+]c and
cAMP. Evidence for a strong reduction of Ca2+ entry in single nerve terminals.
Journal of Biological Chemistry. 277(16), 14092–14101.
mla: Millán, Carmelo, et al. “The Inhibition of Glutamate Release by Metabotropic
Glutamate Receptor 7 Affects Both [Ca2+]c and CAMP. Evidence for a Strong Reduction
of Ca2+ Entry in Single Nerve Terminals.” Journal of Biological Chemistry,
vol. 277, no. 16, American Society for Biochemistry and Molecular Biology, 2002,
pp. 14092–101, doi:10.1074/jbc.M109044200.
short: C. Millán, R. Luján, R. Shigemoto, J. Sánchez Prieto, Journal of Biological
Chemistry 277 (2002) 14092–14101.
date_created: 2018-12-11T11:58:41Z
date_published: 2002-04-19T00:00:00Z
date_updated: 2023-07-25T10:16:44Z
day: '19'
ddc:
- '570'
doi: 10.1074/jbc.M109044200
extern: '1'
external_id:
pmid:
- '11825890'
file:
- access_level: open_access
checksum: 0290fcbbd9153ec654185b0c856f214c
content_type: application/pdf
creator: alisjak
date_created: 2023-07-25T10:13:16Z
date_updated: 2023-07-25T10:13:16Z
file_id: '13309'
file_name: 2002_JBC_Millan.pdf
file_size: 2105520
relation: main_file
success: 1
file_date_updated: 2023-07-25T10:13:16Z
has_accepted_license: '1'
intvolume: ' 277'
issue: '16'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: 14092 - 14101
pmid: 1
publication: Journal of Biological Chemistry
publication_identifier:
issn:
- 0021-9258
publication_status: published
publisher: American Society for Biochemistry and Molecular Biology
publist_id: '4284'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The inhibition of glutamate release by metabotropic glutamate receptor 7 affects
both [Ca2+]c and cAMP. Evidence for a strong reduction of Ca2+ entry in single nerve
terminals
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 277
year: '2002'
...
---
_id: '2615'
abstract:
- lang: eng
text: Taste-mGluR4, cloned from taste tissues, is a truncated variant of brain-expressed
mGluR4a (brain-mGluR4), and is known to be a candidate for the receptor involved
in the umami taste sense. Although the expression patterns of taste- and brain-mGluR4
mRNAs have been demonstrated, no mention has so far been made of the expression
of these two mGluR4 proteins in taste tissues. The present study examined the
expression of taste-mGluR4 and brain-mGluR4 proteins in rat taste tissues by using
a specific antibody for mGluR4a which shared a C-terminus of both taste- and brain-mGluR4,
for immunoblot analysis and immunohistochemistry. Immunoblot analysis showed that
both brain-mGluR4 and taste-mGluR4 were expressed in the taste tissues. Taste-mGluR4
was not detected in the cerebellum. The immunoreactive band for brain-mGluR4 protein
was much stronger than that for taste-mGluR4 protein. In the cryosections of fungiform,
foliate and circumvallate papillae, the antibody against taste-mGluR4 exhibited
intense labeling of the taste pores and taste hairs in all the taste buds of gustatory
papillae examined; the immunoreaction to the antibody against brain-mGluR4 was
more intense at the same sites of the taste buds. The portions of the taste bud
cells below the taste pore and surrounding keratinocytes did not show any immunoreactivities.
The results of the present study strongly suggest that, in addition to taste-mGluR4,
brain-mGluR4 may function even more importantly than the former as a receptor
for glutamate, i.e. the umami taste sensation.
article_processing_charge: No
article_type: original
author:
- first_name: Takashi
full_name: Toyono, Takashi
last_name: Toyono
- first_name: Yuji
full_name: Seta, Yuji
last_name: Seta
- first_name: Shinji
full_name: Sataoka, Shinji
last_name: Sataoka
- first_name: Harumi
full_name: Harada, Harumi
id: 2E55CDF2-F248-11E8-B48F-1D18A9856A87
last_name: Harada
orcid: 0000-0001-7429-7896
- first_name: Takahiko
full_name: Morotomi, Takahiko
last_name: Morotomi
- first_name: Shintaro
full_name: Kawano, Shintaro
last_name: Kawano
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Kuniaki
full_name: Toyoshima, Kuniaki
last_name: Toyoshima
citation:
ama: Toyono T, Seta Y, Sataoka S, et al. Expression of the metabotropic glutamate
receptor, mGluR4a, in the taste hairs of taste buds in rat gustatory papillae.
Archives of Histology and Cytology. 2002;65(1):91-96. doi:10.1679/aohc.65.91
apa: Toyono, T., Seta, Y., Sataoka, S., Harada, H., Morotomi, T., Kawano, S., …
Toyoshima, K. (2002). Expression of the metabotropic glutamate receptor, mGluR4a,
in the taste hairs of taste buds in rat gustatory papillae. Archives of Histology
and Cytology. Japan Society of Histological Documentation. https://doi.org/10.1679/aohc.65.91
chicago: Toyono, Takashi, Yuji Seta, Shinji Sataoka, Harumi Harada, Takahiko Morotomi,
Shintaro Kawano, Ryuichi Shigemoto, and Kuniaki Toyoshima. “Expression of the
Metabotropic Glutamate Receptor, MGluR4a, in the Taste Hairs of Taste Buds in
Rat Gustatory Papillae.” Archives of Histology and Cytology. Japan Society
of Histological Documentation, 2002. https://doi.org/10.1679/aohc.65.91.
ieee: T. Toyono et al., “Expression of the metabotropic glutamate receptor,
mGluR4a, in the taste hairs of taste buds in rat gustatory papillae,” Archives
of Histology and Cytology, vol. 65, no. 1. Japan Society of Histological Documentation,
pp. 91–96, 2002.
ista: Toyono T, Seta Y, Sataoka S, Harada H, Morotomi T, Kawano S, Shigemoto R,
Toyoshima K. 2002. Expression of the metabotropic glutamate receptor, mGluR4a,
in the taste hairs of taste buds in rat gustatory papillae. Archives of Histology
and Cytology. 65(1), 91–96.
mla: Toyono, Takashi, et al. “Expression of the Metabotropic Glutamate Receptor,
MGluR4a, in the Taste Hairs of Taste Buds in Rat Gustatory Papillae.” Archives
of Histology and Cytology, vol. 65, no. 1, Japan Society of Histological Documentation,
2002, pp. 91–96, doi:10.1679/aohc.65.91.
short: T. Toyono, Y. Seta, S. Sataoka, H. Harada, T. Morotomi, S. Kawano, R. Shigemoto,
K. Toyoshima, Archives of Histology and Cytology 65 (2002) 91–96.
date_created: 2018-12-11T11:58:41Z
date_published: 2002-01-01T00:00:00Z
date_updated: 2023-07-25T10:00:15Z
day: '01'
doi: 10.1679/aohc.65.91
extern: '1'
external_id:
pmid:
- '12002614'
intvolume: ' 65'
issue: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 91 - 96
pmid: 1
publication: Archives of Histology and Cytology
publication_identifier:
issn:
- 0914-9465
publication_status: published
publisher: Japan Society of Histological Documentation
publist_id: '4283'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Expression of the metabotropic glutamate receptor, mGluR4a, in the taste hairs
of taste buds in rat gustatory papillae
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 65
year: '2002'
...
---
_id: '2616'
abstract:
- lang: eng
text: Neurons in the rat cerebral cortex are enriched in group I metabotropic glutamate
receptor (mGluR) subtypes and respond to their activation during development.
To understand better the mechanisms by which mGluR1 and mGluR5 mediate these effects,
the goal of this study was to elucidate the expression pattern and to determine
the cellular and the precise subcellular localization of these two receptor subtypes
in the rat neocortex and hippocampus during late prenatal and postnatal development.
At the light microscopic level, mGluR1 α and mGluR5 were first detected in the
cerebral cortex with different expression levels at embryonic day E18. Thus, mGluR5
had a moderate expression, whereas mGluR1 α was detected as a diffuse and weak
labeling. mGluR5 was localized in some Cajal-Retzius cells as well as in other
cell types, such as pioneer neurons of the marginal zone. During postnatal development,
the distribution of the receptors dramatically changed. From P0 to around P10,
mGluR1α was localized in identified, transient Cajal-Retzius cells of neocortex
and hippocampus, until these cells disappear. In addition, a population of interneurons
localized the receptor from the second/third postnatal week. In contrast, mGluR5
was localized mainly in pyramidal cells and in some interneurons, with a neuropilar
staining throughout the cerebral cortex. At the electron microscopic level, the
immunoreactivity for both group I mGluR subtypes was expressed postsynaptically.
Using immunogold methods, mGluR1α and mGluR5 immunoreactivities were found throughout
postnatal development at the edge of postsynaptic specialization of asymmetrical
synapses. These results show that the two group I mGluRs have a differential expression
pattern in neocortex and hippocampus that may suggest roles for the receptors
in the early processing of cortical information and in the control of cortical
developmental events.
acknowledgement: The authors are grateful to Dr Ole Paulsen and Professor Kay Davies
for their comments on the manuscript. We also would like to thank Dr Zoltan Molnar
for his support and Mrs Lucy Jones, Ms Courtney Voelker and Mr David Dongworth for
the English revision of the manuscript. This work was supported by grants from the
European Community (QLG3-CT-1999-00192 to R.L.) and the Spanish Ministerio de Ciencia
y Tecnología (PB97-0582-CO2-01 to A.F.).
article_processing_charge: No
article_type: original
author:
- first_name: Guillermina
full_name: López Bendito, Guillermina
last_name: López Bendito
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Alfonso
full_name: Fairén, Alfonso
last_name: Fairén
- first_name: Rafael
full_name: Luján, Rafael
last_name: Luján
citation:
ama: López Bendito G, Shigemoto R, Fairén A, Luján R. Differential distribution
of group I metabotropic glutamate receptors during rat cortical development. Cerebral
Cortex. 2002;12(6):625-638. doi:10.1093/cercor/12.6.625
apa: López Bendito, G., Shigemoto, R., Fairén, A., & Luján, R. (2002). Differential
distribution of group I metabotropic glutamate receptors during rat cortical development.
Cerebral Cortex. Oxford University Press. https://doi.org/10.1093/cercor/12.6.625
chicago: López Bendito, Guillermina, Ryuichi Shigemoto, Alfonso Fairén, and Rafael
Luján. “Differential Distribution of Group I Metabotropic Glutamate Receptors
during Rat Cortical Development.” Cerebral Cortex. Oxford University Press,
2002. https://doi.org/10.1093/cercor/12.6.625.
ieee: G. López Bendito, R. Shigemoto, A. Fairén, and R. Luján, “Differential distribution
of group I metabotropic glutamate receptors during rat cortical development,”
Cerebral Cortex, vol. 12, no. 6. Oxford University Press, pp. 625–638,
2002.
ista: López Bendito G, Shigemoto R, Fairén A, Luján R. 2002. Differential distribution
of group I metabotropic glutamate receptors during rat cortical development. Cerebral
Cortex. 12(6), 625–638.
mla: López Bendito, Guillermina, et al. “Differential Distribution of Group I Metabotropic
Glutamate Receptors during Rat Cortical Development.” Cerebral Cortex,
vol. 12, no. 6, Oxford University Press, 2002, pp. 625–38, doi:10.1093/cercor/12.6.625.
short: G. López Bendito, R. Shigemoto, A. Fairén, R. Luján, Cerebral Cortex 12 (2002)
625–638.
date_created: 2018-12-11T11:58:41Z
date_published: 2002-06-01T00:00:00Z
date_updated: 2023-07-25T09:54:10Z
day: '01'
doi: 10.1093/cercor/12.6.625
extern: '1'
external_id:
pmid:
- '12003862'
intvolume: ' 12'
issue: '6'
language:
- iso: eng
month: '06'
oa_version: None
page: 625 - 638
pmid: 1
publication: Cerebral Cortex
publication_identifier:
issn:
- 1047-3211
publication_status: published
publisher: Oxford University Press
publist_id: '4282'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Differential distribution of group I metabotropic glutamate receptors during
rat cortical development
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 12
year: '2002'
...
---
_id: '2617'
abstract:
- lang: eng
text: Synapses exhibit different short-term plasticity patterns and this behaviour
influences information processing in neuronal networks. We tested how the short-term
plasticity of excitatory postsynaptic currents (EPSCs) depends on the postsynaptic
cell type, identified by axonal arborizations and molecular markers in the hippocampal
CA1 area. Three distinct types of short-term synaptic behaviour (facilitating,
depressing and combined facilitating-depressing) were defined by fitting a dynamic
neurotransmission model to the data. Approximately 75 % of the oriens-lacunosum-moleculare
(O-LM) interneurones received facilitating EPSCs, but in three of 12 O-LM cells
EPSCs also showed significant depression. Over 90 % of the O-LM cells were immunopositive
for somatostatin and mGluR1α and all tested cells were decorated by strongly mGluR7a
positive axon terminals. Responses in eight of 12 basket cells were described
well with a model involving only depression, but the other cells displayed combined
facilitating-depressing EPSCs. No apparent difference was found between the plasticity
of EPSCs in cholecystokinin- or parvalbumin-containing basket cells. In oriens-bistratified
cells (O-Bi), two of nine cells showed facilitating EPSCs, another two depressing,
and the remaining five cells combined facilitating-depressing EPSCs. Seven of
10 cells tested for somatostatin were immunopositive, but mGluR1α was detectable
only in two of 11 tested cells. Furthermore, most O-Bi cells projected to the
CA3 area and the subiculum, as well as outside the hippocampal formation. Postsynaptic
responses to action potentials recorded in vivo from a CA1 place cell were modelled,
and revealed great differences between and within cell types. Our results demonstrate
that the short-term plasticity of EPSCs is cell type dependent, but with significant
heterogeneity within all three interneurone populations.
author:
- first_name: Attila
full_name: Losonczy, Attila
last_name: Losonczy
- first_name: Limei
full_name: Zhang, Limei
last_name: Zhang
- first_name: Ryuichi
full_name: Ryuichi Shigemoto
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Péter
full_name: Somogyi, Péter
last_name: Somogyi
- first_name: Zoltán
full_name: Nusser, Zoltán
last_name: Nusser
citation:
ama: Losonczy A, Zhang L, Shigemoto R, Somogyi P, Nusser Z. Cell type dependence
and variability in the short-term plasticity of EPSCs in identified mouse hippocampal
interneurones. Journal of Physiology. 2002;542(1):193-210. doi:10.1113/jphysiol.2002.020024
apa: Losonczy, A., Zhang, L., Shigemoto, R., Somogyi, P., & Nusser, Z. (2002).
Cell type dependence and variability in the short-term plasticity of EPSCs in
identified mouse hippocampal interneurones. Journal of Physiology. Wiley-Blackwell.
https://doi.org/10.1113/jphysiol.2002.020024
chicago: Losonczy, Attila, Limei Zhang, Ryuichi Shigemoto, Péter Somogyi, and Zoltán
Nusser. “Cell Type Dependence and Variability in the Short-Term Plasticity of
EPSCs in Identified Mouse Hippocampal Interneurones.” Journal of Physiology.
Wiley-Blackwell, 2002. https://doi.org/10.1113/jphysiol.2002.020024.
ieee: A. Losonczy, L. Zhang, R. Shigemoto, P. Somogyi, and Z. Nusser, “Cell type
dependence and variability in the short-term plasticity of EPSCs in identified
mouse hippocampal interneurones,” Journal of Physiology, vol. 542, no.
1. Wiley-Blackwell, pp. 193–210, 2002.
ista: Losonczy A, Zhang L, Shigemoto R, Somogyi P, Nusser Z. 2002. Cell type dependence
and variability in the short-term plasticity of EPSCs in identified mouse hippocampal
interneurones. Journal of Physiology. 542(1), 193–210.
mla: Losonczy, Attila, et al. “Cell Type Dependence and Variability in the Short-Term
Plasticity of EPSCs in Identified Mouse Hippocampal Interneurones.” Journal
of Physiology, vol. 542, no. 1, Wiley-Blackwell, 2002, pp. 193–210, doi:10.1113/jphysiol.2002.020024.
short: A. Losonczy, L. Zhang, R. Shigemoto, P. Somogyi, Z. Nusser, Journal of Physiology
542 (2002) 193–210.
date_created: 2018-12-11T11:58:42Z
date_published: 2002-07-01T00:00:00Z
date_updated: 2021-01-12T06:58:36Z
day: '01'
doi: 10.1113/jphysiol.2002.020024
extern: 1
intvolume: ' 542'
issue: '1'
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2290398/
month: '07'
oa: 1
page: 193 - 210
publication: Journal of Physiology
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4281'
quality_controlled: 0
status: public
title: Cell type dependence and variability in the short-term plasticity of EPSCs
in identified mouse hippocampal interneurones
type: journal_article
volume: 542
year: '2002'
...
---
_id: '2618'
abstract:
- lang: eng
text: The unipolar brush cell (UBC) is a type of glutamatergic interneuron in the
granular layer of the cerebellum. The UBC brush and a single mossy fiber (MF)
terminal contact each other within a cerebellar glomerulus, forming a giant synapse.
Many UBCs receive input from extrinsic MFs, whereas others are innervated by intrinsic
mossy terminals formed by the axons of other UBCs. In all mammalian species so
far examined, the vestibulocerebellum is enriched of UBCs that are strongly immunoreactive
for the calcium binding protein calretinin (CR) in both the somatodendritic and
axonal compartment. UBCs have postsynaptic ionotropic glutamate receptors and
extrasynaptic metabotropic glutamate receptors that immunocytochemically highlight
their somatodendritic compartment and brush, respectively. In this study on the
mouse cerebellum, we present evidence that immunoreactivities to CR and mGluR1α
define two distinct UBC subsets with partly overlapping distributions in lobule
X (the nodulus). In sections double-labeled for CR and mGluR1α, the patterns of
distributions of CR+/mGluR1α- UBCs and CR-/mGluR1α+ UBCs differed along the mediolateral
and dorsoventral axes of the folium. Moreover, mGluR1α+ UBCs outnumbered CR+ UBCs.
Both UBC subsets were mGluR2/3, GluR2/3, and NMDAR1 immunoreactive. The different
distribution patterns of the two UBC subsets within lobule X suggest that expression
of CR or mGluR1α by UBCs may be afferent-specific and related to the terminal
fields of different vestibular MF afferents.
article_processing_charge: No
article_type: original
author:
- first_name: Maria
full_name: Nunzi, Maria
last_name: Nunzi
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Enrico
full_name: Mugnaini, Enrico
last_name: Mugnaini
citation:
ama: Nunzi M, Shigemoto R, Mugnaini E. Differential expression of calretinin and
metabotropic glutamate receptor mGluR1α defines subsets of unipolar brush cells
in mouse cerebellum. Journal of Comparative Neurology. 2002;451(2):189-199.
doi:10.1002/cne.10344
apa: Nunzi, M., Shigemoto, R., & Mugnaini, E. (2002). Differential expression
of calretinin and metabotropic glutamate receptor mGluR1α defines subsets of unipolar
brush cells in mouse cerebellum. Journal of Comparative Neurology. Wiley-Blackwell.
https://doi.org/10.1002/cne.10344
chicago: Nunzi, Maria, Ryuichi Shigemoto, and Enrico Mugnaini. “Differential Expression
of Calretinin and Metabotropic Glutamate Receptor MGluR1α Defines Subsets of Unipolar
Brush Cells in Mouse Cerebellum.” Journal of Comparative Neurology. Wiley-Blackwell,
2002. https://doi.org/10.1002/cne.10344.
ieee: M. Nunzi, R. Shigemoto, and E. Mugnaini, “Differential expression of calretinin
and metabotropic glutamate receptor mGluR1α defines subsets of unipolar brush
cells in mouse cerebellum,” Journal of Comparative Neurology, vol. 451,
no. 2. Wiley-Blackwell, pp. 189–199, 2002.
ista: Nunzi M, Shigemoto R, Mugnaini E. 2002. Differential expression of calretinin
and metabotropic glutamate receptor mGluR1α defines subsets of unipolar brush
cells in mouse cerebellum. Journal of Comparative Neurology. 451(2), 189–199.
mla: Nunzi, Maria, et al. “Differential Expression of Calretinin and Metabotropic
Glutamate Receptor MGluR1α Defines Subsets of Unipolar Brush Cells in Mouse Cerebellum.”
Journal of Comparative Neurology, vol. 451, no. 2, Wiley-Blackwell, 2002,
pp. 189–99, doi:10.1002/cne.10344.
short: M. Nunzi, R. Shigemoto, E. Mugnaini, Journal of Comparative Neurology 451
(2002) 189–199.
date_created: 2018-12-11T11:58:42Z
date_published: 2002-09-16T00:00:00Z
date_updated: 2023-07-25T09:09:48Z
day: '16'
doi: 10.1002/cne.10344
extern: '1'
external_id:
pmid:
- '12209836'
intvolume: ' 451'
issue: '2'
language:
- iso: eng
month: '09'
oa_version: None
page: 189 - 199
pmid: 1
publication: Journal of Comparative Neurology
publication_identifier:
issn:
- 0021-9967
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4279'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Differential expression of calretinin and metabotropic glutamate receptor mGluR1α
defines subsets of unipolar brush cells in mouse cerebellum
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 451
year: '2002'
...
---
_id: '2619'
abstract:
- lang: eng
text: The release of glutamate and GABA is modulated by presynaptic metabotropic
glutamate receptors (mGluRs). We used immunocytochemical methods to define the
location of the group III receptor mGluR7a in glutamatergic and GABAergic terminals
innervating GABAergic interneurons and pyramidal cells. Immunoreactivity for mGluR7a
was localized in the presynaptic active zone of both identified GABAergic and
presumed glutamatergic terminals. Terminals innervating dendritic spines showed
a variable level of receptor immunoreactivity, ranging from immunonegative to
strongly immunopositive. The frequency of strongly mGluR7a positive terminals
innervating the soma and dendrites of mGluR1α/somatostatin-expressing interneurons
was very high relative to other neurons. On dendrites that received mGluR7a-enriched
glutamatergic innervation, at least 80% of GABAergic terminals were immunopositive
for mGluR7a. On such dendrites virtually all (95%) vasoactive intestinal polypeptide
(VIP) positive (GABAergic) terminals were enriched in mGluR7a. The targets of
VIP/mGluR7a-expressing terminals were mainly (88%) mGluR1α-expressing interneurons,
which were mostly somatostatin immunopositive. Parvalbumin positive terminals
were immunonegative for mGluR7a. Some parvalbumin immunoreactive dendrites received
strongly mGluR7a positive terminals. The subcellular location, as well as the
cell type and synapse-specific distribution of mGluR7a in isocortical neuronal
circuits, is homologous to its distribution in the hippocampus. The specific location
of mGluR7a in the presynaptic active zone of both glutamatergic and GABAergic
synapses may be related to the proximity of calcium channels and the vesicle fusion
machinery. The enrichment of mGluR7a in the main GABAergic, as well as in the
glutamatergic, innervation of mGluR1α/somatostatin-expressing interneurons suggests
that their activation is under unique regulation by extracellular glutamate.
acknowledgement: We thank Dr C. Paspalas for an initial contribution to the immunocytochemistry.
We are grateful for the generous gifts of antibodies from Dr A. Buchan (anti-somatostatin,
Department of Physiology, University of British Columbia, Canada), Dr M. Watanabe
(anti-mGluR1α, Department of Anatomy, Hokkaido University School of Medicine, Sapporo)
and Dr K. Tanaka (anti-GAD, Niigata University, Faculty of Medicine, Department
of Neurology). We thank Dr F. Ferraguti for helpful suggestions during the project
and for his comments on a previous version of the manuscript. We also thank Philip
Cobden, Paul Jays and Laszlo Marton for assistance. Y.D. was supported by a Wellcome
Trust Advanced Training Fellowship.
article_processing_charge: No
article_type: original
author:
- first_name: Yannis
full_name: Dalezios, Yannis
last_name: Dalezios
- first_name: Rafael
full_name: Luján, Rafael
last_name: Luján
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: John
full_name: Roberts, John
last_name: Roberts
- first_name: Péter
full_name: Somogyi, Péter
last_name: Somogyi
citation:
ama: Dalezios Y, Luján R, Shigemoto R, Roberts J, Somogyi P. Enrichment of mGluR7a
in the Presynaptic active zones of GABAergic and Non-GABAergic terminals on interneurons
in the rat somatosensory cortex. Cerebral Cortex. 2002;12(9):961-974. doi:10.1093/cercor/12.9.961
apa: Dalezios, Y., Luján, R., Shigemoto, R., Roberts, J., & Somogyi, P. (2002).
Enrichment of mGluR7a in the Presynaptic active zones of GABAergic and Non-GABAergic
terminals on interneurons in the rat somatosensory cortex. Cerebral Cortex.
Oxford University Press. https://doi.org/10.1093/cercor/12.9.961
chicago: Dalezios, Yannis, Rafael Luján, Ryuichi Shigemoto, John Roberts, and Péter
Somogyi. “Enrichment of MGluR7a in the Presynaptic Active Zones of GABAergic and
Non-GABAergic Terminals on Interneurons in the Rat Somatosensory Cortex.” Cerebral
Cortex. Oxford University Press, 2002. https://doi.org/10.1093/cercor/12.9.961.
ieee: Y. Dalezios, R. Luján, R. Shigemoto, J. Roberts, and P. Somogyi, “Enrichment
of mGluR7a in the Presynaptic active zones of GABAergic and Non-GABAergic terminals
on interneurons in the rat somatosensory cortex,” Cerebral Cortex, vol.
12, no. 9. Oxford University Press, pp. 961–974, 2002.
ista: Dalezios Y, Luján R, Shigemoto R, Roberts J, Somogyi P. 2002. Enrichment of
mGluR7a in the Presynaptic active zones of GABAergic and Non-GABAergic terminals
on interneurons in the rat somatosensory cortex. Cerebral Cortex. 12(9), 961–974.
mla: Dalezios, Yannis, et al. “Enrichment of MGluR7a in the Presynaptic Active Zones
of GABAergic and Non-GABAergic Terminals on Interneurons in the Rat Somatosensory
Cortex.” Cerebral Cortex, vol. 12, no. 9, Oxford University Press, 2002,
pp. 961–74, doi:10.1093/cercor/12.9.961.
short: Y. Dalezios, R. Luján, R. Shigemoto, J. Roberts, P. Somogyi, Cerebral Cortex
12 (2002) 961–974.
date_created: 2018-12-11T11:58:42Z
date_published: 2002-09-01T00:00:00Z
date_updated: 2023-07-25T09:40:49Z
day: '01'
doi: 10.1093/cercor/12.9.961
extern: '1'
external_id:
pmid:
- '12183395'
intvolume: ' 12'
issue: '9'
language:
- iso: eng
month: '09'
oa_version: None
page: 961 - 974
pmid: 1
publication: Cerebral Cortex
publication_identifier:
issn:
- 1047-3211
publication_status: published
publisher: Oxford University Press
publist_id: '4280'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Enrichment of mGluR7a in the Presynaptic active zones of GABAergic and Non-GABAergic
terminals on interneurons in the rat somatosensory cortex
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 12
year: '2002'
...
---
_id: '2620'
abstract:
- lang: eng
text: An ion channel's function depends largely on its location and density on neurons.
Here we used high-resolution immunolocalization to determine the subcellular distribution
of the hyperpolarization-activated and cyclic-nucleotide-gated channel subunit
1 (HCN1) in rat brain. Light microscopy revealed graded HCN1 immunoreactivity
in apical dendrites of hippocampal, subicular and neocortical layer-5 pyramidal
cells. Quantitative comparison of immunogold densities showed a 60-fold increase
from somatic to distal apical dendritic membranes. Distal dendritic shafts had
16 times more HCN1 labeling than proximal dendrites of similar diameters. At the
same distance from the soma, the density of HCN1 was significantly higher in dendritic
shafts than in spines. Our results reveal the complex cell surface distribution
of voltage-gated ion-channels, and predict its role in increasing the computational
power of single neurons via subcellular domain and input-specific mechanisms.
acknowledgement: Z.N. received grants from the Hungarian Science Foundation (T032309),
the Howard Hughes Medical Institute, the James S. McDonnell Foundation, the Wellcome
Trust and the Boehringer Ingelheim Fund. Z.N. and R.S. received grants from CREST—Japan
Science and Technology Corporation. G.T. is funded by the Wellcome Trust.
article_processing_charge: No
article_type: original
author:
- first_name: Andrea
full_name: Lörincz, Andrea
last_name: Lörincz
- first_name: Takuya
full_name: Notomi, Takuya
last_name: Notomi
- first_name: Gábor
full_name: Tamás, Gábor
last_name: Tamás
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Zoltán
full_name: Nusser, Zoltán
last_name: Nusser
citation:
ama: Lörincz A, Notomi T, Tamás G, Shigemoto R, Nusser Z. Polarized and compartment-dependent
distribution of HCN1 in pyramidal cell dendrites. Nature Neuroscience.
2002;5(11):1185-1193. doi:10.1038/nn962
apa: Lörincz, A., Notomi, T., Tamás, G., Shigemoto, R., & Nusser, Z. (2002).
Polarized and compartment-dependent distribution of HCN1 in pyramidal cell dendrites.
Nature Neuroscience. Nature Publishing Group. https://doi.org/10.1038/nn962
chicago: Lörincz, Andrea, Takuya Notomi, Gábor Tamás, Ryuichi Shigemoto, and Zoltán
Nusser. “Polarized and Compartment-Dependent Distribution of HCN1 in Pyramidal
Cell Dendrites.” Nature Neuroscience. Nature Publishing Group, 2002. https://doi.org/10.1038/nn962.
ieee: A. Lörincz, T. Notomi, G. Tamás, R. Shigemoto, and Z. Nusser, “Polarized and
compartment-dependent distribution of HCN1 in pyramidal cell dendrites,” Nature
Neuroscience, vol. 5, no. 11. Nature Publishing Group, pp. 1185–1193, 2002.
ista: Lörincz A, Notomi T, Tamás G, Shigemoto R, Nusser Z. 2002. Polarized and compartment-dependent
distribution of HCN1 in pyramidal cell dendrites. Nature Neuroscience. 5(11),
1185–1193.
mla: Lörincz, Andrea, et al. “Polarized and Compartment-Dependent Distribution of
HCN1 in Pyramidal Cell Dendrites.” Nature Neuroscience, vol. 5, no. 11,
Nature Publishing Group, 2002, pp. 1185–93, doi:10.1038/nn962.
short: A. Lörincz, T. Notomi, G. Tamás, R. Shigemoto, Z. Nusser, Nature Neuroscience
5 (2002) 1185–1193.
date_created: 2018-12-11T11:58:43Z
date_published: 2002-11-01T00:00:00Z
date_updated: 2023-07-25T09:02:48Z
day: '01'
doi: 10.1038/nn962
extern: '1'
external_id:
pmid:
- '12389030'
intvolume: ' 5'
issue: '11'
language:
- iso: eng
month: '11'
oa_version: None
page: 1185 - 1193
pmid: 1
publication: Nature Neuroscience
publication_identifier:
issn:
- 1097-6256
publication_status: published
publisher: Nature Publishing Group
publist_id: '4278'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Polarized and compartment-dependent distribution of HCN1 in pyramidal cell
dendrites
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 5
year: '2002'
...
---
_id: '2621'
abstract:
- lang: eng
text: The release properties of glutamatergic nerve terminals are influenced by
a number of factors, including the subtype of voltage-dependent calcium channel
and the presence of presynaptic autoreceptors. Group III metabotropic glutamate
receptors (mGluRs) mediate feedback inhibition of glutamate release by inhibiting
Ca2+ channel activity. By imaging Ca2+ in preparations of cerebrocortical nerve
terminals, we show that voltage-dependent Ca2+ channels are distributed in a heterogeneous
manner in individual nerve terminals. Presynaptic terminals contained only N-type
(47.5%; conotoxin GVIA-sensitive), P/Q-type (3.9%; agatoxin IVA-sensitive), or
both N- and P/Q-type (42.6%) Ca2+ channels, although the remainder of the terminals
(6.1%) were insensitive to these two toxins. In this preparation, two mGluRs with
high and low affinity for L(+)-2-amino-4-phosphonobutyrate were identified by
immunocytochemistry as mGluR4 and mGluR7, respectively. These receptors were responsible
for 22.2 and 24.1% reduction of glutamate release, and they reduced the Ca2+ response
in 24.4 and 30.3% of the nerve terminals, respectively. Interestingly, mGluR4
was largely (73.7%) located in nerve terminals expressing both N- and P/Q-type
Ca2+ channels, whereas mGluR7 was predominantly (69.9%) located in N-type Ca2+
channel-expressing terminals. This specific coexpression of different group III
mGluRs and Ca2+ channels may endow synaptic terminals with distinct release properties
and reveals the existence of a high degree of presynaptic heterogeneity.
acknowledgement: We thank M. Sefton for editorial assistance.
article_processing_charge: No
article_type: original
author:
- first_name: Carmelo
full_name: Millán, Carmelo
last_name: Millán
- first_name: Rafael
full_name: Luján, Rafael
last_name: Luján
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: José
full_name: Sánchez Prieto, José
last_name: Sánchez Prieto
citation:
ama: Millán C, Luján R, Shigemoto R, Sánchez Prieto J. Subtype-specific expression
of Group III metabotropic glutamate receptors and Ca2+ channels in single nerve
terminals. Journal of Biological Chemistry. 2002;277(49):47796-47803. doi:10.1074/jbc.M207531200
apa: Millán, C., Luján, R., Shigemoto, R., & Sánchez Prieto, J. (2002). Subtype-specific
expression of Group III metabotropic glutamate receptors and Ca2+ channels in
single nerve terminals. Journal of Biological Chemistry. American Society
for Biochemistry and Molecular Biology. https://doi.org/10.1074/jbc.M207531200
chicago: Millán, Carmelo, Rafael Luján, Ryuichi Shigemoto, and José Sánchez Prieto.
“Subtype-Specific Expression of Group III Metabotropic Glutamate Receptors and
Ca2+ Channels in Single Nerve Terminals.” Journal of Biological Chemistry.
American Society for Biochemistry and Molecular Biology, 2002. https://doi.org/10.1074/jbc.M207531200.
ieee: C. Millán, R. Luján, R. Shigemoto, and J. Sánchez Prieto, “Subtype-specific
expression of Group III metabotropic glutamate receptors and Ca2+ channels in
single nerve terminals,” Journal of Biological Chemistry, vol. 277, no.
49. American Society for Biochemistry and Molecular Biology, pp. 47796–47803,
2002.
ista: Millán C, Luján R, Shigemoto R, Sánchez Prieto J. 2002. Subtype-specific expression
of Group III metabotropic glutamate receptors and Ca2+ channels in single nerve
terminals. Journal of Biological Chemistry. 277(49), 47796–47803.
mla: Millán, Carmelo, et al. “Subtype-Specific Expression of Group III Metabotropic
Glutamate Receptors and Ca2+ Channels in Single Nerve Terminals.” Journal of
Biological Chemistry, vol. 277, no. 49, American Society for Biochemistry
and Molecular Biology, 2002, pp. 47796–803, doi:10.1074/jbc.M207531200.
short: C. Millán, R. Luján, R. Shigemoto, J. Sánchez Prieto, Journal of Biological
Chemistry 277 (2002) 47796–47803.
date_created: 2018-12-11T11:58:43Z
date_published: 2002-12-02T00:00:00Z
date_updated: 2023-07-19T07:49:19Z
day: '02'
doi: 10.1074/jbc.M207531200
extern: '1'
external_id:
pmid:
- '12376542'
intvolume: ' 277'
issue: '49'
language:
- iso: eng
month: '12'
oa_version: Published Version
page: 47796 - 47803
pmid: 1
publication: Journal of Biological Chemistry
publication_identifier:
issn:
- 0021-9258
publication_status: published
publisher: American Society for Biochemistry and Molecular Biology
publist_id: '4277'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Subtype-specific expression of Group III metabotropic glutamate receptors and
Ca2+ channels in single nerve terminals
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 277
year: '2002'
...