--- _id: '11124' abstract: - lang: eng text: Ran GTPase plays important roles in nucleocytoplasmic transport in interphase [1, 2] and in both spindle formation and nuclear envelope (NE) assembly during mitosis [3, 4, 5]. The latter functions rely on the presence of high local concentrations of GTP-bound Ran near mitotic chromatin [3, 4, 5]. RanGTP localization has been proposed to result from the association of Ran's GDP/GTP exchange factor, RCC1, with chromatin [6, 7, 8, 9], but Ran is shown here to bind directly to chromatin in two modes, either dependent or independent of RCC1, and, where bound, to increase the affinity of chromatin for NE membranes. We propose that the Ran binding capacity of chromatin contributes to localized spindle and NE assembly. article_processing_charge: No article_type: letter_note author: - first_name: Daniel full_name: Bilbao-Cortés, Daniel last_name: Bilbao-Cortés - first_name: Martin W full_name: HETZER, Martin W id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed last_name: HETZER orcid: 0000-0002-2111-992X - first_name: Gernot full_name: Längst, Gernot last_name: Längst - first_name: Peter B. full_name: Becker, Peter B. last_name: Becker - first_name: Iain W. full_name: Mattaj, Iain W. last_name: Mattaj citation: ama: Bilbao-Cortés D, Hetzer M, Längst G, Becker PB, Mattaj IW. Ran binds to chromatin by two distinct mechanisms. Current Biology. 2002;12(13):1151-1156. doi:10.1016/s0960-9822(02)00927-2 apa: Bilbao-Cortés, D., Hetzer, M., Längst, G., Becker, P. B., & Mattaj, I. W. (2002). Ran binds to chromatin by two distinct mechanisms. Current Biology. Elsevier BV. https://doi.org/10.1016/s0960-9822(02)00927-2 chicago: Bilbao-Cortés, Daniel, Martin Hetzer, Gernot Längst, Peter B. Becker, and Iain W. Mattaj. “Ran Binds to Chromatin by Two Distinct Mechanisms.” Current Biology. Elsevier BV, 2002. https://doi.org/10.1016/s0960-9822(02)00927-2. ieee: D. Bilbao-Cortés, M. Hetzer, G. Längst, P. B. Becker, and I. W. Mattaj, “Ran binds to chromatin by two distinct mechanisms,” Current Biology, vol. 12, no. 13. Elsevier BV, pp. 1151–1156, 2002. ista: Bilbao-Cortés D, Hetzer M, Längst G, Becker PB, Mattaj IW. 2002. Ran binds to chromatin by two distinct mechanisms. Current Biology. 12(13), 1151–1156. mla: Bilbao-Cortés, Daniel, et al. “Ran Binds to Chromatin by Two Distinct Mechanisms.” Current Biology, vol. 12, no. 13, Elsevier BV, 2002, pp. 1151–56, doi:10.1016/s0960-9822(02)00927-2. short: D. Bilbao-Cortés, M. Hetzer, G. Längst, P.B. Becker, I.W. Mattaj, Current Biology 12 (2002) 1151–1156. date_created: 2022-04-07T07:57:31Z date_published: 2002-07-09T00:00:00Z date_updated: 2022-07-18T08:58:05Z day: '09' doi: 10.1016/s0960-9822(02)00927-2 extern: '1' external_id: pmid: - '12121625' intvolume: ' 12' issue: '13' keyword: - General Agricultural and Biological Sciences - General Biochemistry - Genetics and Molecular Biology language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.1016/S0960-9822(02)00927-2 month: '07' oa: 1 oa_version: Published Version page: 1151-1156 pmid: 1 publication: Current Biology publication_identifier: issn: - 0960-9822 publication_status: published publisher: Elsevier BV quality_controlled: '1' scopus_import: '1' status: public title: Ran binds to chromatin by two distinct mechanisms type: journal_article user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd volume: 12 year: '2002' ... --- _id: '11123' abstract: - lang: eng text: The small GTPase Ran is a key regulator of nucleocytoplasmic transport during interphase. The asymmetric distribution of the GTP-bound form of Ran across the nuclear envelope — that is, large quantities in the nucleus compared with small quantities in the cytoplasm — determines the directionality of many nuclear transport processes. Recent findings that Ran also functions in spindle formation and nuclear envelope assembly during mitosis suggest that Ran has a general role in chromatin-centred processes. Ran functions in these events as a signal for chromosome position. article_processing_charge: No article_type: original author: - first_name: Martin W full_name: HETZER, Martin W id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed last_name: HETZER orcid: 0000-0002-2111-992X - first_name: Oliver J. full_name: Gruss, Oliver J. last_name: Gruss - first_name: Iain W. full_name: Mattaj, Iain W. last_name: Mattaj citation: ama: Hetzer M, Gruss OJ, Mattaj IW. The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly. Nature Cell Biology. 2002;4(7):E177-E184. doi:10.1038/ncb0702-e177 apa: Hetzer, M., Gruss, O. J., & Mattaj, I. W. (2002). The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly. Nature Cell Biology. Springer Nature. https://doi.org/10.1038/ncb0702-e177 chicago: Hetzer, Martin, Oliver J. Gruss, and Iain W. Mattaj. “The Ran GTPase as a Marker of Chromosome Position in Spindle Formation and Nuclear Envelope Assembly.” Nature Cell Biology. Springer Nature, 2002. https://doi.org/10.1038/ncb0702-e177. ieee: M. Hetzer, O. J. Gruss, and I. W. Mattaj, “The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly,” Nature Cell Biology, vol. 4, no. 7. Springer Nature, pp. E177–E184, 2002. ista: Hetzer M, Gruss OJ, Mattaj IW. 2002. The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly. Nature Cell Biology. 4(7), E177–E184. mla: Hetzer, Martin, et al. “The Ran GTPase as a Marker of Chromosome Position in Spindle Formation and Nuclear Envelope Assembly.” Nature Cell Biology, vol. 4, no. 7, Springer Nature, 2002, pp. E177–84, doi:10.1038/ncb0702-e177. short: M. Hetzer, O.J. Gruss, I.W. Mattaj, Nature Cell Biology 4 (2002) E177–E184. date_created: 2022-04-07T07:57:19Z date_published: 2002-07-01T00:00:00Z date_updated: 2022-07-18T08:58:03Z day: '01' doi: 10.1038/ncb0702-e177 extern: '1' external_id: pmid: - '12105431' intvolume: ' 4' issue: '7' keyword: - Cell Biology language: - iso: eng month: '07' oa_version: None page: E177-E184 pmid: 1 publication: Nature Cell Biology publication_identifier: eissn: - 1476-4679 issn: - 1465-7392 publication_status: published publisher: Springer Nature quality_controlled: '1' scopus_import: '1' status: public title: The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly type: journal_article user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd volume: 4 year: '2002' ... --- _id: '12659' abstract: - lang: eng text: "For many years considerable efforts have been put into investigating and modelling hydrological processes of mountainous catchments. On the one hand, the complexity and intrinsically high variability of the involved processes as well as insufficient knowledge of the underlying physical mechanisms still induce large uncertainties in understanding observed phenomena and predicting the behaviour of the system. On the other hand, the demand for models that are able to simulate mountainous water resource systems is increasing because of the needs related to both water exploitation and water conservation, which clearly call for an integrated vision and modelling of these systems.\r\nAccordingly, this paper moves from a brief survey of the most significant achievements in mountain hydrology to discuss what could be future challenging issues related to the broader spectrum of questions, which hydrologic modelling of mountainous river systems may face in the next decades. Firstly, reference is made to existing methodologies for modelling alpine water systems, focussing on some specific aspects that provide a basis for the discussion of the weaknesses and perspectives of present simulation tools. The future is thus discussed, delineating some of the research challenges that may foster a comprehensive and integrated vision of water related issues in mountainous regions." article_processing_charge: No article_type: original author: - first_name: Paolo full_name: Burlando, Paolo last_name: Burlando - first_name: Francesca full_name: Pellicciotti, Francesca id: b28f055a-81ea-11ed-b70c-a9fe7f7b0e70 last_name: Pellicciotti - first_name: Ulrich full_name: Strasser, Ulrich last_name: Strasser citation: ama: Burlando P, Pellicciotti F, Strasser U. Modelling mountainous water systems between learning and speculating looking for challenges. Hydrology Research. 2002;33(1):47-74. doi:10.2166/nh.2002.0004 apa: Burlando, P., Pellicciotti, F., & Strasser, U. (2002). Modelling mountainous water systems between learning and speculating looking for challenges. Hydrology Research. IWA Publishing. https://doi.org/10.2166/nh.2002.0004 chicago: Burlando, Paolo, Francesca Pellicciotti, and Ulrich Strasser. “Modelling Mountainous Water Systems between Learning and Speculating Looking for Challenges.” Hydrology Research. IWA Publishing, 2002. https://doi.org/10.2166/nh.2002.0004. ieee: P. Burlando, F. Pellicciotti, and U. Strasser, “Modelling mountainous water systems between learning and speculating looking for challenges,” Hydrology Research, vol. 33, no. 1. IWA Publishing, pp. 47–74, 2002. ista: Burlando P, Pellicciotti F, Strasser U. 2002. Modelling mountainous water systems between learning and speculating looking for challenges. Hydrology Research. 33(1), 47–74. mla: Burlando, Paolo, et al. “Modelling Mountainous Water Systems between Learning and Speculating Looking for Challenges.” Hydrology Research, vol. 33, no. 1, IWA Publishing, 2002, pp. 47–74, doi:10.2166/nh.2002.0004. short: P. Burlando, F. Pellicciotti, U. Strasser, Hydrology Research 33 (2002) 47–74. date_created: 2023-02-20T08:19:02Z date_published: 2002-02-01T00:00:00Z date_updated: 2023-02-20T08:30:15Z day: '01' doi: 10.2166/nh.2002.0004 extern: '1' intvolume: ' 33' issue: '1' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.2166/nh.2002.0004 month: '02' oa: 1 oa_version: Published Version page: 47-74 publication: Hydrology Research publication_identifier: eissn: - 2224-7955 issn: - 0029-1277 publication_status: published publisher: IWA Publishing quality_controlled: '1' scopus_import: '1' status: public title: Modelling mountainous water systems between learning and speculating looking for challenges type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 33 year: '2002' ... --- _id: '1738' abstract: - lang: eng text: New dyes of the type Ru(II)(bdmpp)(bpy) [where bdmpp is 2,6-bis(3,5-dimethyl-N-pyrazoyl)pyridine and bpy is 2,2′-bipyridine-4,4′-dicarboxylic acid] are prepared and characterized by infra-red (IR), mass (MS) and electrospray mass spectroscopy (ES-MS) as well as 1H NMR (1D and 2D) spectroscopies. The compounds present broad and very high intensity MLCT absorption bands in the visible and can be chemically anchored on TiO2 films via ester-like linkage involving carboxylato groups. These complexes have been tested with success as potential molecular antennas in dye-sensitized solar cells. Both opaque and transparent nanocrystalline TiO2 thin film electrodes obtained by a doctor blade technique sensitized by these complexes were incorporated in a sandwich type regenerative photoelectrochemical solar cell containing 0.1M LiI +0.01M I2 in propylene carbonate as well as a platinized conductive glass counter electrode. The cell was characterized by Raman spectroscopy under anodic and cathodic bias. Two new vibration bands were observed in the lower frequency region. The first one at 112 cm-1 is due to tri-iodide formed on the photoactive electrode, and the second one at 167 cm-1 is a sign of the dye/iodide interaction and corresponds to a vibration in a chemically stable "DI" intermediate species. Under direct sunlight illumination (solar irradiance of 60 mW/cm2) by using a composite polymer solid state electrolyte, the cell ITO/TiO2/[Ru(II)(bdmpp)(bpy)(NCS)](PF6)/electrolyte/Pt-ITO produced a continuous photocurrent as high as 4.29mA/cm2, and gave IPCE values about half of the corresponding values obtained by the standard N3 dye under the same conditions. The photovoltage is about 600 mV and the overall energy conversion cell's efficiency is as high as 1.72%. author: - first_name: Polycarpos full_name: Falaras, Polycarpos last_name: Falaras - first_name: Katerina full_name: Chryssou, Katerina last_name: Chryssou - first_name: Thomas full_name: Stergiopoulos, Thomas last_name: Stergiopoulos - first_name: Ioannis full_name: Arabatzis, Ioannis M last_name: Arabatzis - first_name: Georgios full_name: Georgios Katsaros id: 38DB5788-F248-11E8-B48F-1D18A9856A87 last_name: Katsaros - first_name: Vincent full_name: Catalano, Vincent J last_name: Catalano - first_name: Raif full_name: Kurtaran, Raif last_name: Kurtaran - first_name: Anne full_name: Hugot-Le Goff, Anne last_name: Hugot Le Goff - first_name: Marie full_name: Bernard, Marie C last_name: Bernard citation: ama: 'Falaras P, Chryssou K, Stergiopoulos T, et al. Dye-sensitization of titanium dioxide thin films by Ru(II)-bpp-bpy complexes. In: Vol 4801. SPIE; 2002:125-135. doi:10.1117/12.452446' apa: Falaras, P., Chryssou, K., Stergiopoulos, T., Arabatzis, I., Katsaros, G., Catalano, V., … Bernard, M. (2002). Dye-sensitization of titanium dioxide thin films by Ru(II)-bpp-bpy complexes (Vol. 4801, pp. 125–135). Presented at the Organic Photovoltaics, SPIE. https://doi.org/10.1117/12.452446 chicago: Falaras, Polycarpos, Katerina Chryssou, Thomas Stergiopoulos, Ioannis Arabatzis, Georgios Katsaros, Vincent Catalano, Raif Kurtaran, Anne Hugot Le Goff, and Marie Bernard. “Dye-Sensitization of Titanium Dioxide Thin Films by Ru(II)-Bpp-Bpy Complexes,” 4801:125–35. SPIE, 2002. https://doi.org/10.1117/12.452446. ieee: P. Falaras et al., “Dye-sensitization of titanium dioxide thin films by Ru(II)-bpp-bpy complexes,” presented at the Organic Photovoltaics, 2002, vol. 4801, pp. 125–135. ista: Falaras P, Chryssou K, Stergiopoulos T, Arabatzis I, Katsaros G, Catalano V, Kurtaran R, Hugot Le Goff A, Bernard M. 2002. Dye-sensitization of titanium dioxide thin films by Ru(II)-bpp-bpy complexes. Organic Photovoltaics vol. 4801, 125–135. mla: Falaras, Polycarpos, et al. Dye-Sensitization of Titanium Dioxide Thin Films by Ru(II)-Bpp-Bpy Complexes. Vol. 4801, SPIE, 2002, pp. 125–35, doi:10.1117/12.452446. short: P. Falaras, K. Chryssou, T. Stergiopoulos, I. Arabatzis, G. Katsaros, V. Catalano, R. Kurtaran, A. Hugot Le Goff, M. Bernard, in:, SPIE, 2002, pp. 125–135. conference: name: Organic Photovoltaics date_created: 2018-12-11T11:53:45Z date_published: 2002-01-01T00:00:00Z date_updated: 2021-01-12T06:52:53Z day: '01' doi: 10.1117/12.452446 extern: 1 intvolume: ' 4801' month: '01' page: 125 - 135 publication_status: published publisher: SPIE publist_id: '5385' quality_controlled: 0 status: public title: Dye-sensitization of titanium dioxide thin films by Ru(II)-bpp-bpy complexes type: conference volume: 4801 year: '2002' ... --- _id: '1739' abstract: - lang: eng text: Poly(ethylene oxide)/titania polymer electrolyte based photoelectrochemical cells have been fabricated with Ru(dcbpy)2(NCS)2 complex as the sensitizer and nanoporous TiO2 films as photoanodes. The introduction of the titania filler into the poly(ethylene oxide) matrix reduces the crystallinity of the polymer and enhances the mobility of the 1-/13 - redox couple, resulting in outstanding overall conversion efficiency (4.2% under direct sunlight illumination) of the corresponding dye-sensitized nanocrystalline TiO2 solar cell, one of the best efficiencies reported to date for a solid-state device. acknowledgement: 'Financial support from NCSR “Demokritos” and GSRT-Greece is greatly acknowledged. ' author: - first_name: Thomas full_name: Stergiopoulos, Thomas last_name: Stergiopoulos - first_name: Iannis full_name: Arabatzis, Iannis M last_name: Arabatzis - first_name: Georgios full_name: Georgios Katsaros id: 38DB5788-F248-11E8-B48F-1D18A9856A87 last_name: Katsaros - first_name: Polycarpos full_name: Falaras, Polycarpos last_name: Falaras citation: ama: Stergiopoulos T, Arabatzis I, Katsaros G, Falaras P. Binary Polyethylene Oxide/Titania Solid-State Redox Electrolyte for Highly Efficient Nanocrystalline TiO2 Photoelectrochemical Cells. Nano Letters. 2002;2(11):1259-1261. doi:10.1021/nl025798u apa: Stergiopoulos, T., Arabatzis, I., Katsaros, G., & Falaras, P. (2002). Binary Polyethylene Oxide/Titania Solid-State Redox Electrolyte for Highly Efficient Nanocrystalline TiO2 Photoelectrochemical Cells. Nano Letters. American Chemical Society. https://doi.org/10.1021/nl025798u chicago: Stergiopoulos, Thomas, Iannis Arabatzis, Georgios Katsaros, and Polycarpos Falaras. “Binary Polyethylene Oxide/Titania Solid-State Redox Electrolyte for Highly Efficient Nanocrystalline TiO2 Photoelectrochemical Cells.” Nano Letters. American Chemical Society, 2002. https://doi.org/10.1021/nl025798u. ieee: T. Stergiopoulos, I. Arabatzis, G. Katsaros, and P. Falaras, “Binary Polyethylene Oxide/Titania Solid-State Redox Electrolyte for Highly Efficient Nanocrystalline TiO2 Photoelectrochemical Cells,” Nano Letters, vol. 2, no. 11. American Chemical Society, pp. 1259–1261, 2002. ista: Stergiopoulos T, Arabatzis I, Katsaros G, Falaras P. 2002. Binary Polyethylene Oxide/Titania Solid-State Redox Electrolyte for Highly Efficient Nanocrystalline TiO2 Photoelectrochemical Cells. Nano Letters. 2(11), 1259–1261. mla: Stergiopoulos, Thomas, et al. “Binary Polyethylene Oxide/Titania Solid-State Redox Electrolyte for Highly Efficient Nanocrystalline TiO2 Photoelectrochemical Cells.” Nano Letters, vol. 2, no. 11, American Chemical Society, 2002, pp. 1259–61, doi:10.1021/nl025798u. short: T. Stergiopoulos, I. Arabatzis, G. Katsaros, P. Falaras, Nano Letters 2 (2002) 1259–1261. date_created: 2018-12-11T11:53:45Z date_published: 2002-11-01T00:00:00Z date_updated: 2021-01-12T06:52:53Z day: '01' doi: 10.1021/nl025798u extern: 1 intvolume: ' 2' issue: '11' month: '11' page: 1259 - 1261 publication: Nano Letters publication_status: published publisher: American Chemical Society publist_id: '5386' quality_controlled: 0 status: public title: Binary Polyethylene Oxide/Titania Solid-State Redox Electrolyte for Highly Efficient Nanocrystalline TiO2 Photoelectrochemical Cells type: journal_article volume: 2 year: '2002' ... --- _id: '2339' alternative_title: - Contemporary Mathematics author: - first_name: Robert full_name: Robert Seiringer id: 4AFD0470-F248-11E8-B48F-1D18A9856A87 last_name: Seiringer orcid: 0000-0002-6781-0521 citation: ama: 'Seiringer R. Symmetry breaking in a model of a rotating Bose gas. In: Weder R, Exner P, Grébert B, eds. Vol 307. World Scientific Publishing; 2002:281-286. doi:10.1090/conm/307' apa: 'Seiringer, R. (2002). Symmetry breaking in a model of a rotating Bose gas. In R. Weder, P. Exner, & B. Grébert (Eds.) (Vol. 307, pp. 281–286). Presented at the QMath: Mathematical Results in Quantum Physics, World Scientific Publishing. https://doi.org/10.1090/conm/307' chicago: Seiringer, Robert. “Symmetry Breaking in a Model of a Rotating Bose Gas.” edited by Richardo Weder, Pavel Exner, and Benoit Grébert, 307:281–86. World Scientific Publishing, 2002. https://doi.org/10.1090/conm/307. ieee: 'R. Seiringer, “Symmetry breaking in a model of a rotating Bose gas,” presented at the QMath: Mathematical Results in Quantum Physics, 2002, vol. 307, pp. 281–286.' ista: 'Seiringer R. 2002. Symmetry breaking in a model of a rotating Bose gas. QMath: Mathematical Results in Quantum Physics, Contemporary Mathematics, vol. 307, 281–286.' mla: Seiringer, Robert. Symmetry Breaking in a Model of a Rotating Bose Gas. Edited by Richardo Weder et al., vol. 307, World Scientific Publishing, 2002, pp. 281–86, doi:10.1090/conm/307. short: R. Seiringer, in:, R. Weder, P. Exner, B. Grébert (Eds.), World Scientific Publishing, 2002, pp. 281–286. conference: name: 'QMath: Mathematical Results in Quantum Physics' date_created: 2018-12-11T11:57:05Z date_published: 2002-01-01T00:00:00Z date_updated: 2021-01-12T06:56:53Z day: '01' doi: 10.1090/conm/307 editor: - first_name: Richardo full_name: Weder, Richardo last_name: Weder - first_name: Pavel full_name: Exner, Pavel last_name: Exner - first_name: Benoit full_name: Grébert, Benoit last_name: Grébert extern: 1 intvolume: ' 307' month: '01' page: 281 - 286 publication_status: published publisher: World Scientific Publishing publist_id: '4587' quality_controlled: 0 status: public title: Symmetry breaking in a model of a rotating Bose gas type: conference volume: 307 year: '2002' ... --- _id: '2351' abstract: - lang: eng text: We study the Gross-Pitaevskii functional for a rotating two-dimensional Bose gas in a trap. We prove that there is a breaking of the rotational symmetry in the ground state; more precisely, for any value of the angular velocity and for large enough values of the interaction strength, the ground state of the functional is not an eigenfunction of the angular momentum. This has interesting consequences on the Bose gas with spin; in particular, the ground state energy depends non-trivially on the number of spin components, and the different components do not have the same wave function. For the special case of a harmonic trap potential, we give explicit upper and lower bounds on the critical coupling constant for symmetry breaking. author: - first_name: Robert full_name: Robert Seiringer id: 4AFD0470-F248-11E8-B48F-1D18A9856A87 last_name: Seiringer orcid: 0000-0002-6781-0521 citation: ama: Seiringer R. Gross-Pitaevskii theory of the rotating Bose gas. Communications in Mathematical Physics. 2002;229(3):491-509. doi:10.1007/s00220-002-0695-2 apa: Seiringer, R. (2002). Gross-Pitaevskii theory of the rotating Bose gas. Communications in Mathematical Physics. Springer. https://doi.org/10.1007/s00220-002-0695-2 chicago: Seiringer, Robert. “Gross-Pitaevskii Theory of the Rotating Bose Gas.” Communications in Mathematical Physics. Springer, 2002. https://doi.org/10.1007/s00220-002-0695-2. ieee: R. Seiringer, “Gross-Pitaevskii theory of the rotating Bose gas,” Communications in Mathematical Physics, vol. 229, no. 3. Springer, pp. 491–509, 2002. ista: Seiringer R. 2002. Gross-Pitaevskii theory of the rotating Bose gas. Communications in Mathematical Physics. 229(3), 491–509. mla: Seiringer, Robert. “Gross-Pitaevskii Theory of the Rotating Bose Gas.” Communications in Mathematical Physics, vol. 229, no. 3, Springer, 2002, pp. 491–509, doi:10.1007/s00220-002-0695-2. short: R. Seiringer, Communications in Mathematical Physics 229 (2002) 491–509. date_created: 2018-12-11T11:57:09Z date_published: 2002-09-01T00:00:00Z date_updated: 2021-01-12T06:56:57Z day: '01' doi: 10.1007/s00220-002-0695-2 extern: 1 intvolume: ' 229' issue: '3' main_file_link: - open_access: '1' url: http://arxiv.org/abs/math-ph/0110010 month: '09' oa: 1 page: 491 - 509 publication: Communications in Mathematical Physics publication_status: published publisher: Springer publist_id: '4575' quality_controlled: 0 status: public title: Gross-Pitaevskii theory of the rotating Bose gas type: journal_article volume: 229 year: '2002' ... --- _id: '2349' abstract: - lang: eng text: The Bose-Einstein condensation (BEC) of the ground state of bosonic atoms in a trap was discussed. The BEC was proved for bosons with two-body repulsive interaction potentials in the dilute limit, starting from the basic Schrodinger equation. The BEC was 100% into the state which minimized the Gross-Pitaevskii energy functional. The analysis also included rigorous proof of BEC in a physically realistic, continuum model. author: - first_name: Élliott full_name: Lieb, Élliott H last_name: Lieb - first_name: Robert full_name: Robert Seiringer id: 4AFD0470-F248-11E8-B48F-1D18A9856A87 last_name: Seiringer orcid: 0000-0002-6781-0521 citation: ama: Lieb É, Seiringer R. Proof of Bose-Einstein condensation for dilute trapped gases. Physical Review Letters. 2002;88(17):1704091-1704094. doi:10.1103/PhysRevLett.88.170409 apa: Lieb, É., & Seiringer, R. (2002). Proof of Bose-Einstein condensation for dilute trapped gases. Physical Review Letters. American Physical Society. https://doi.org/10.1103/PhysRevLett.88.170409 chicago: Lieb, Élliott, and Robert Seiringer. “Proof of Bose-Einstein Condensation for Dilute Trapped Gases.” Physical Review Letters. American Physical Society, 2002. https://doi.org/10.1103/PhysRevLett.88.170409. ieee: É. Lieb and R. Seiringer, “Proof of Bose-Einstein condensation for dilute trapped gases,” Physical Review Letters, vol. 88, no. 17. American Physical Society, pp. 1704091–1704094, 2002. ista: Lieb É, Seiringer R. 2002. Proof of Bose-Einstein condensation for dilute trapped gases. Physical Review Letters. 88(17), 1704091–1704094. mla: Lieb, Élliott, and Robert Seiringer. “Proof of Bose-Einstein Condensation for Dilute Trapped Gases.” Physical Review Letters, vol. 88, no. 17, American Physical Society, 2002, pp. 1704091–94, doi:10.1103/PhysRevLett.88.170409. short: É. Lieb, R. Seiringer, Physical Review Letters 88 (2002) 1704091–1704094. date_created: 2018-12-11T11:57:08Z date_published: 2002-04-29T00:00:00Z date_updated: 2021-01-12T06:56:56Z day: '29' doi: 10.1103/PhysRevLett.88.170409 extern: 1 intvolume: ' 88' issue: '17' main_file_link: - open_access: '1' url: http://arxiv.org/abs/math-ph/0112032 month: '04' oa: 1 page: 1704091 - 1704094 publication: Physical Review Letters publication_status: published publisher: American Physical Society publist_id: '4577' quality_controlled: 0 status: public title: Proof of Bose-Einstein condensation for dilute trapped gases type: journal_article volume: 88 year: '2002' ... --- _id: '2352' abstract: - lang: eng text: We present a generalization of the Fefferman-de la Llave decomposition of the Coulomb potential to quite arbitrary radial functions V on ℝn going to zero at infinity. This generalized decomposition can be used to extend previous results on N-body quantum systems with Coulomb interaction to a more general class of interactions. As an example of such an application, we derive the high density asymptotics of the ground state energy of jellium with Yukawa interaction in the thermodynamic limit, using a correlation estimate by Graf and Solovej. author: - first_name: Christian full_name: Hainzl, Christian last_name: Hainzl - first_name: Robert full_name: Robert Seiringer id: 4AFD0470-F248-11E8-B48F-1D18A9856A87 last_name: Seiringer orcid: 0000-0002-6781-0521 citation: ama: Hainzl C, Seiringer R. General decomposition of radial functions on ℝn and applications to N-body quantum systems. Letters in Mathematical Physics. 2002;61(1):75-84. doi:10.1023/A:1020204818938 apa: Hainzl, C., & Seiringer, R. (2002). General decomposition of radial functions on ℝn and applications to N-body quantum systems. Letters in Mathematical Physics. Springer. https://doi.org/10.1023/A:1020204818938 chicago: Hainzl, Christian, and Robert Seiringer. “General Decomposition of Radial Functions on ℝn and Applications to N-Body Quantum Systems.” Letters in Mathematical Physics. Springer, 2002. https://doi.org/10.1023/A:1020204818938. ieee: C. Hainzl and R. Seiringer, “General decomposition of radial functions on ℝn and applications to N-body quantum systems,” Letters in Mathematical Physics, vol. 61, no. 1. Springer, pp. 75–84, 2002. ista: Hainzl C, Seiringer R. 2002. General decomposition of radial functions on ℝn and applications to N-body quantum systems. Letters in Mathematical Physics. 61(1), 75–84. mla: Hainzl, Christian, and Robert Seiringer. “General Decomposition of Radial Functions on ℝn and Applications to N-Body Quantum Systems.” Letters in Mathematical Physics, vol. 61, no. 1, Springer, 2002, pp. 75–84, doi:10.1023/A:1020204818938. short: C. Hainzl, R. Seiringer, Letters in Mathematical Physics 61 (2002) 75–84. date_created: 2018-12-11T11:57:09Z date_published: 2002-07-01T00:00:00Z date_updated: 2021-01-12T06:56:58Z day: '01' doi: 10.1023/A:1020204818938 extern: 1 intvolume: ' 61' issue: '1' main_file_link: - open_access: '1' url: http://arxiv.org/abs/math-ph/0107011 month: '07' oa: 1 page: 75 - 84 publication: Letters in Mathematical Physics publication_status: published publisher: Springer publist_id: '4576' quality_controlled: 0 status: public title: General decomposition of radial functions on ℝn and applications to N-body quantum systems type: journal_article volume: 61 year: '2002' ... --- _id: '2617' abstract: - lang: eng text: Synapses exhibit different short-term plasticity patterns and this behaviour influences information processing in neuronal networks. We tested how the short-term plasticity of excitatory postsynaptic currents (EPSCs) depends on the postsynaptic cell type, identified by axonal arborizations and molecular markers in the hippocampal CA1 area. Three distinct types of short-term synaptic behaviour (facilitating, depressing and combined facilitating-depressing) were defined by fitting a dynamic neurotransmission model to the data. Approximately 75 % of the oriens-lacunosum-moleculare (O-LM) interneurones received facilitating EPSCs, but in three of 12 O-LM cells EPSCs also showed significant depression. Over 90 % of the O-LM cells were immunopositive for somatostatin and mGluR1α and all tested cells were decorated by strongly mGluR7a positive axon terminals. Responses in eight of 12 basket cells were described well with a model involving only depression, but the other cells displayed combined facilitating-depressing EPSCs. No apparent difference was found between the plasticity of EPSCs in cholecystokinin- or parvalbumin-containing basket cells. In oriens-bistratified cells (O-Bi), two of nine cells showed facilitating EPSCs, another two depressing, and the remaining five cells combined facilitating-depressing EPSCs. Seven of 10 cells tested for somatostatin were immunopositive, but mGluR1α was detectable only in two of 11 tested cells. Furthermore, most O-Bi cells projected to the CA3 area and the subiculum, as well as outside the hippocampal formation. Postsynaptic responses to action potentials recorded in vivo from a CA1 place cell were modelled, and revealed great differences between and within cell types. Our results demonstrate that the short-term plasticity of EPSCs is cell type dependent, but with significant heterogeneity within all three interneurone populations. author: - first_name: Attila full_name: Losonczy, Attila last_name: Losonczy - first_name: Limei full_name: Zhang, Limei last_name: Zhang - first_name: Ryuichi full_name: Ryuichi Shigemoto id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 - first_name: Péter full_name: Somogyi, Péter last_name: Somogyi - first_name: Zoltán full_name: Nusser, Zoltán last_name: Nusser citation: ama: Losonczy A, Zhang L, Shigemoto R, Somogyi P, Nusser Z. Cell type dependence and variability in the short-term plasticity of EPSCs in identified mouse hippocampal interneurones. Journal of Physiology. 2002;542(1):193-210. doi:10.1113/jphysiol.2002.020024 apa: Losonczy, A., Zhang, L., Shigemoto, R., Somogyi, P., & Nusser, Z. (2002). Cell type dependence and variability in the short-term plasticity of EPSCs in identified mouse hippocampal interneurones. Journal of Physiology. Wiley-Blackwell. https://doi.org/10.1113/jphysiol.2002.020024 chicago: Losonczy, Attila, Limei Zhang, Ryuichi Shigemoto, Péter Somogyi, and Zoltán Nusser. “Cell Type Dependence and Variability in the Short-Term Plasticity of EPSCs in Identified Mouse Hippocampal Interneurones.” Journal of Physiology. Wiley-Blackwell, 2002. https://doi.org/10.1113/jphysiol.2002.020024. ieee: A. Losonczy, L. Zhang, R. Shigemoto, P. Somogyi, and Z. Nusser, “Cell type dependence and variability in the short-term plasticity of EPSCs in identified mouse hippocampal interneurones,” Journal of Physiology, vol. 542, no. 1. Wiley-Blackwell, pp. 193–210, 2002. ista: Losonczy A, Zhang L, Shigemoto R, Somogyi P, Nusser Z. 2002. Cell type dependence and variability in the short-term plasticity of EPSCs in identified mouse hippocampal interneurones. Journal of Physiology. 542(1), 193–210. mla: Losonczy, Attila, et al. “Cell Type Dependence and Variability in the Short-Term Plasticity of EPSCs in Identified Mouse Hippocampal Interneurones.” Journal of Physiology, vol. 542, no. 1, Wiley-Blackwell, 2002, pp. 193–210, doi:10.1113/jphysiol.2002.020024. short: A. Losonczy, L. Zhang, R. Shigemoto, P. Somogyi, Z. Nusser, Journal of Physiology 542 (2002) 193–210. date_created: 2018-12-11T11:58:42Z date_published: 2002-07-01T00:00:00Z date_updated: 2021-01-12T06:58:36Z day: '01' doi: 10.1113/jphysiol.2002.020024 extern: 1 intvolume: ' 542' issue: '1' main_file_link: - open_access: '1' url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2290398/ month: '07' oa: 1 page: 193 - 210 publication: Journal of Physiology publication_status: published publisher: Wiley-Blackwell publist_id: '4281' quality_controlled: 0 status: public title: Cell type dependence and variability in the short-term plasticity of EPSCs in identified mouse hippocampal interneurones type: journal_article volume: 542 year: '2002' ... --- _id: '2708' alternative_title: - Contemporary Mathematics author: - first_name: László full_name: László Erdös id: 4DBD5372-F248-11E8-B48F-1D18A9856A87 last_name: Erdös orcid: 0000-0001-5366-9603 citation: ama: 'Erdös L. Two dimensional Pauli operator via scalar potential. In: Vol 307. World Scientific Publishing; 2002:129-133. doi:10.1090/conm/307' apa: 'Erdös, L. (2002). Two dimensional Pauli operator via scalar potential (Vol. 307, pp. 129–133). Presented at the QMath: Mathematical Results in Quantum Physics, World Scientific Publishing. https://doi.org/10.1090/conm/307' chicago: Erdös, László. “Two Dimensional Pauli Operator via Scalar Potential,” 307:129–33. World Scientific Publishing, 2002. https://doi.org/10.1090/conm/307. ieee: 'L. Erdös, “Two dimensional Pauli operator via scalar potential,” presented at the QMath: Mathematical Results in Quantum Physics, 2002, vol. 307, pp. 129–133.' ista: 'Erdös L. 2002. Two dimensional Pauli operator via scalar potential. QMath: Mathematical Results in Quantum Physics, Contemporary Mathematics, vol. 307, 129–133.' mla: Erdös, László. Two Dimensional Pauli Operator via Scalar Potential. Vol. 307, World Scientific Publishing, 2002, pp. 129–33, doi:10.1090/conm/307. short: L. Erdös, in:, World Scientific Publishing, 2002, pp. 129–133. conference: name: 'QMath: Mathematical Results in Quantum Physics' date_created: 2018-12-11T11:59:11Z date_published: 2002-01-01T00:00:00Z date_updated: 2021-01-12T06:59:11Z day: '01' doi: 10.1090/conm/307 extern: 1 intvolume: ' 307' month: '01' page: 129 - 133 publication_status: published publisher: World Scientific Publishing publist_id: '4188' quality_controlled: 0 status: public title: Two dimensional Pauli operator via scalar potential type: conference volume: 307 year: '2002' ... --- _id: '2991' abstract: - lang: eng text: Polar auxin transport controls multiple aspects of plant development including differential growth, embryo and root patterning and vascular tissue differentiation. Identification of proteins involved in this process and availability of new tools enabling `visualization' of auxin and auxin routes in planta largely contributed to the significant progress that has recently been made. New data support classical concepts, but several recent findings are likely to challenge our view on the mechanism of auxin transport. The aim of this review is to provide a comprehensive overview of the polar auxin transport field. It starts with classical models resulting from physiological studies, describes the genetic contributions and discusses the molecular basis of auxin influx and efflux. Finally, selected questions are presented in the context of developmental biology, integrating available data from different fields. author: - first_name: Jirí full_name: Friml, Jirí id: 4159519E-F248-11E8-B48F-1D18A9856A87 last_name: Friml orcid: 0000-0002-8302-7596 - first_name: Klaus full_name: Palme, Klaus last_name: Palme citation: ama: Friml J, Palme K. Polar auxin transport - Old questions and new concepts? Plant Molecular Biology. 2002;49(3-4):273-284. doi:10.1023/A:1015248926412 apa: Friml, J., & Palme, K. (2002). Polar auxin transport - Old questions and new concepts? Plant Molecular Biology. Springer. https://doi.org/10.1023/A:1015248926412 chicago: Friml, Jiří, and Klaus Palme. “Polar Auxin Transport - Old Questions and New Concepts?” Plant Molecular Biology. Springer, 2002. https://doi.org/10.1023/A:1015248926412. ieee: J. Friml and K. Palme, “Polar auxin transport - Old questions and new concepts?,” Plant Molecular Biology, vol. 49, no. 3–4. Springer, pp. 273–284, 2002. ista: Friml J, Palme K. 2002. Polar auxin transport - Old questions and new concepts? Plant Molecular Biology. 49(3–4), 273–284. mla: Friml, Jiří, and Klaus Palme. “Polar Auxin Transport - Old Questions and New Concepts?” Plant Molecular Biology, vol. 49, no. 3–4, Springer, 2002, pp. 273–84, doi:10.1023/A:1015248926412. short: J. Friml, K. Palme, Plant Molecular Biology 49 (2002) 273–284. date_created: 2018-12-11T12:00:44Z date_published: 2002-06-01T00:00:00Z date_updated: 2021-01-12T07:40:17Z day: '01' doi: 10.1023/A:1015248926412 extern: '1' intvolume: ' 49' issue: 3-4 language: - iso: eng month: '06' oa_version: None page: 273 - 284 publication: Plant Molecular Biology publication_status: published publisher: Springer publist_id: '3712' quality_controlled: '1' status: public title: Polar auxin transport - Old questions and new concepts? type: journal_article user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87 volume: 49 year: '2002' ... --- _id: '3508' abstract: - lang: eng text: A method of automatic conversion of a physical object into a three-dimensional digital model. The method acquires a set of measured data points on the surface of a physical model. From the measured data points, the method reconstructs a digital model of the physical object using a Delaunay complex of the points, a flow strcuture of the simplicies in the Delaunay complex and retracting the Delaunay complex into a digital model of the physical object using the flow structure. The method then outputs the digital model of the physical object. applicant: - Raindrop Geomagic, Inc. article_processing_charge: No author: - first_name: Herbert full_name: Edelsbrunner, Herbert id: 3FB178DA-F248-11E8-B48F-1D18A9856A87 last_name: Edelsbrunner orcid: 0000-0002-9823-6833 - first_name: Ping full_name: Fu, Ping last_name: Fu citation: ama: Edelsbrunner H, Fu P. Methods of generating three-dimensional digital models of objects by wrapping point cloud data points. 2002. apa: Edelsbrunner, H., & Fu, P. (2002). Methods of generating three-dimensional digital models of objects by wrapping point cloud data points. chicago: Edelsbrunner, Herbert, and Ping Fu. “Methods of Generating Three-Dimensional Digital Models of Objects by Wrapping Point Cloud Data Points,” 2002. ieee: H. Edelsbrunner and P. Fu, “Methods of generating three-dimensional digital models of objects by wrapping point cloud data points.” 2002. ista: Edelsbrunner H, Fu P. 2002. Methods of generating three-dimensional digital models of objects by wrapping point cloud data points. mla: Edelsbrunner, Herbert, and Ping Fu. Methods of Generating Three-Dimensional Digital Models of Objects by Wrapping Point Cloud Data Points. 2002. short: H. Edelsbrunner, P. Fu, (2002). date_created: 2018-12-11T12:03:42Z date_published: 2002-04-23T00:00:00Z date_updated: 2022-01-05T14:09:36Z day: '23' extern: '1' ipc: G16Z99/00 ; G06K9/28 ; G06T17/10 ; G06T17/20 ipn: US6377865B1 main_file_link: - open_access: '1' url: https://patents.google.com/patent/US6377865B1 month: '04' oa: 1 oa_version: Published Version publication_date: 2002-04-23 publist_id: '2879' status: public title: Methods of generating three-dimensional digital models of objects by wrapping point cloud data points type: patent user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9 year: '2002' ... --- _id: '3448' author: - first_name: Sanhita full_name: Mallick, Sanhita last_name: Mallick - first_name: Krishnendu full_name: Krishnendu Chatterjee id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87 last_name: Chatterjee orcid: 0000-0002-4561-241X - first_name: Arif full_name: Merchant, Arif N last_name: Merchant - first_name: Pallab full_name: Dasgupta, Pallab last_name: Dasgupta citation: ama: 'Mallick S, Chatterjee K, Merchant A, Dasgupta P. Implementation of shape grammar for plan analysis. In: Elsevier; 2002.' apa: 'Mallick, S., Chatterjee, K., Merchant, A., & Dasgupta, P. (2002). Implementation of shape grammar for plan analysis. Presented at the IT-Built: Information Technology For Built Environment, Elsevier.' chicago: Mallick, Sanhita, Krishnendu Chatterjee, Arif Merchant, and Pallab Dasgupta. “Implementation of Shape Grammar for Plan Analysis.” Elsevier, 2002. ieee: 'S. Mallick, K. Chatterjee, A. Merchant, and P. Dasgupta, “Implementation of shape grammar for plan analysis,” presented at the IT-Built: Information Technology For Built Environment, 2002.' ista: 'Mallick S, Chatterjee K, Merchant A, Dasgupta P. 2002. Implementation of shape grammar for plan analysis. IT-Built: Information Technology For Built Environment.' mla: Mallick, Sanhita, et al. Implementation of Shape Grammar for Plan Analysis. Elsevier, 2002. short: S. Mallick, K. Chatterjee, A. Merchant, P. Dasgupta, in:, Elsevier, 2002. conference: name: 'IT-Built: Information Technology For Built Environment' date_created: 2018-12-11T12:03:23Z date_published: 2002-01-15T00:00:00Z date_updated: 2021-01-12T07:43:31Z day: '15' extern: 1 month: '01' publication_status: published publisher: Elsevier publist_id: '2939' quality_controlled: 0 status: public title: Implementation of shape grammar for plan analysis type: conference year: '2002' ... --- _id: '4414' abstract: - lang: eng text: "This dissertation investigates game-theoretic approaches to the algorithmic analysis of concurrent, reactive systems. A concurrent system comprises a number of components working concurrently; a reactive system maintains an ongoing interaction with its environment. Traditional approaches to the formal analysis of concurrent reactive systems usually view the system as an unstructured state-transition graphs; instead, we view them as collections of interacting components, where each one is an open system which accepts inputs from the other components. The interactions among the components are naturally modeled as games.\r\n\r\nAdopting this game-theoretic view, we study three related problems pertaining to the verification and synthesis of systems. Firstly, we propose two novel game-theoretic techniques for the model-checking of concurrent reactive systems, and improve the performance of model-checking. The first technique discovers an error as soon as it cannot be prevented, which can be long before it actually occurs. This technique is based on the key observation that "unpreventability" is a local property to a module: an error is unpreventable in a module state if no environment can prevent it. The second technique attempts to decompose a model-checking proof into smaller proof obligations by constructing abstract modules automatically, using reachability and "unpreventability" information about the concrete modules. Three increasingly powerful proof decomposition rules are proposed and we show that in practice, the resulting abstract modules are often significantly smaller than the concrete modules and can drastically reduce the space and time requirements for verification. Both techniques fall into the category of compositional reasoning.\r\n\r\nSecondly, we investigate the composition and control of synchronous systems. An essential property of synchronous systems for compositional reasoning is non-blocking. In the composition of synchronous systems, however, due to circular causal dependency of input and output signals, non-blocking is not always guaranteed. Blocking compositions of systems can be ruled out semantically, by insisting on the existence of certain fixed points, or syntactically, by equipping systems with types, which make the dependencies between input and output signals transparent. We characterize various typing mechanisms in game-theoretic terms, and study their effects on the controller synthesis problem. We show that our typing systems are general enough to capture interesting real-life synchronous systems such as all delay-insensitive digital circuits. We then study their corresponding single-step control problems --a restricted form of controller synthesis problem whose solutions can be iterated in appropriate manners to solve all LTL controller synthesis problems. We also consider versions of the controller synthesis problem in which the type of the controller is given. We show that the solution of these fixed-type control problems requires the evaluation of partially ordered (Henkin) quantifiers on boolean formulas, and is therefore harder (nondeterministic exponential time) than more traditional control questions.\r\n\r\nThirdly, we study the synthesis of a class of open systems, namely, uninitialized state machines. The sequential synthesis problem, which is closely related to Church's solvability problem, asks, given a specification in the form of a binary relation between input and output streams, for the construction of a finite-state stream transducer that converts inputs to appropriate outputs. For efficiency reasons, practical sequential hardware is often designed to operate without prior initialization. Such hardware designs can be modeled by uninitialized state machines, which are required to satisfy their specification if started from any state. We solve the sequential synthesis problem for uninitialized systems, that is, we construct uninitialized finite-state stream transducers. We consider specifications given by LTL formulas, deterministic, nondeterministic, universal, and alternating Buechi automata. We solve this uninitialized synthesis problem by reducing it to the well-understood initialized synthesis problem. While our solution is straightforward, it leads, for some specification formalisms, to upper bounds that are exponentially worse than the complexity of the corresponding initialized problems. However, we prove lower bounds to show that our simple solutions are optimal for all considered specification formalisms. The lower bound proofs require nontrivial generic reductions." article_processing_charge: No author: - first_name: Freddy full_name: Mang, Freddy last_name: Mang citation: ama: Mang F. Games in open systems verification and synthesis. 2002:1-116. apa: Mang, F. (2002). Games in open systems verification and synthesis. University of California, Berkeley. chicago: Mang, Freddy. “Games in Open Systems Verification and Synthesis.” University of California, Berkeley, 2002. ieee: F. Mang, “Games in open systems verification and synthesis,” University of California, Berkeley, 2002. ista: Mang F. 2002. Games in open systems verification and synthesis. University of California, Berkeley. mla: Mang, Freddy. Games in Open Systems Verification and Synthesis. University of California, Berkeley, 2002, pp. 1–116. short: F. Mang, Games in Open Systems Verification and Synthesis, University of California, Berkeley, 2002. date_created: 2018-12-11T12:08:44Z date_published: 2002-05-01T00:00:00Z date_updated: 2021-01-12T07:56:48Z day: '01' extern: '1' language: - iso: eng month: '05' oa_version: None page: 1 - 116 publication_status: published publisher: University of California, Berkeley publist_id: '315' status: public supervisor: - first_name: Thomas A full_name: Henzinger, Thomas A id: 40876CD8-F248-11E8-B48F-1D18A9856A87 last_name: Henzinger orcid: 0000-0002-2985-7724 title: Games in open systems verification and synthesis type: dissertation user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 year: '2002' ... --- _id: '6158' abstract: - lang: eng text: Wild isolates of Caenorhabditis elegans can feed either alone or in groups1,2. This natural variation in behaviour is associated with a single residue difference in NPR-1, a predicted G-protein-coupled neuropeptide receptor related to Neuropeptide Y receptors2. Here we show that the NPR-1 isoform associated with solitary feeding acts in neurons exposed to the body fluid to inhibit social feeding. Furthermore, suppressing the activity of these neurons, called AQR, PQR and URX, using an activated K+ channel, inhibits social feeding. NPR-1 activity in AQR, PQR and URX neurons seems to suppress social feeding by antagonizing signalling through a cyclic GMP-gated ion channel encoded by tax-2 and tax-4. We show that mutations in tax-2 or tax-4 disrupt social feeding, and that tax-4 is required in several neurons for social feeding, including one or more of AQR, PQR and URX. The AQR, PQR and URX neurons are unusual in C. elegans because they are directly exposed to the pseudocoelomic body fluid3. Our data suggest a model in which these neurons integrate antagonistic signals to control the choice between social and solitary feeding behaviour. author: - first_name: Juliet C. full_name: Coates, Juliet C. last_name: Coates - first_name: Mario full_name: de Bono, Mario id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87 last_name: de Bono orcid: 0000-0001-8347-0443 citation: ama: Coates JC, de Bono M. Antagonistic pathways in neurons exposed to body fluid regulate social feeding in Caenorhabditis elegans. Nature. 2002;419(6910):925-929. doi:10.1038/nature01170 apa: Coates, J. C., & de Bono, M. (2002). Antagonistic pathways in neurons exposed to body fluid regulate social feeding in Caenorhabditis elegans. Nature. Springer Nature. https://doi.org/10.1038/nature01170 chicago: Coates, Juliet C., and Mario de Bono. “Antagonistic Pathways in Neurons Exposed to Body Fluid Regulate Social Feeding in Caenorhabditis Elegans.” Nature. Springer Nature, 2002. https://doi.org/10.1038/nature01170. ieee: J. C. Coates and M. de Bono, “Antagonistic pathways in neurons exposed to body fluid regulate social feeding in Caenorhabditis elegans,” Nature, vol. 419, no. 6910. Springer Nature, pp. 925–929, 2002. ista: Coates JC, de Bono M. 2002. Antagonistic pathways in neurons exposed to body fluid regulate social feeding in Caenorhabditis elegans. Nature. 419(6910), 925–929. mla: Coates, Juliet C., and Mario de Bono. “Antagonistic Pathways in Neurons Exposed to Body Fluid Regulate Social Feeding in Caenorhabditis Elegans.” Nature, vol. 419, no. 6910, Springer Nature, 2002, pp. 925–29, doi:10.1038/nature01170. short: J.C. Coates, M. de Bono, Nature 419 (2002) 925–929. date_created: 2019-03-21T10:09:20Z date_published: 2002-10-31T00:00:00Z date_updated: 2021-01-12T08:06:26Z day: '31' doi: 10.1038/nature01170 extern: '1' external_id: pmid: - '12410311' intvolume: ' 419' issue: '6910' language: - iso: eng month: '10' oa_version: None page: 925-929 pmid: 1 publication: Nature publication_identifier: issn: - 0028-0836 publication_status: published publisher: Springer Nature quality_controlled: '1' status: public title: Antagonistic pathways in neurons exposed to body fluid regulate social feeding in Caenorhabditis elegans type: journal_article user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87 volume: 419 year: '2002' ... --- _id: '6159' abstract: - lang: eng text: 'Natural Caenorhabditis elegans isolates exhibit either social or solitary feeding on bacteria. We show here that social feeding is induced by nociceptive neurons that detect adverse or stressful conditions. Ablation of the nociceptive neurons ASH and ADL transforms social animals into solitary feeders. Social feeding is probably due to the sensation of noxious chemicals by ASH and ADL neurons; it requires the genes ocr-2 and osm-9, which encode TRP-related transduction channels, and odr-4 and odr-8, which are required to localize sensory chemoreceptors to cilia. Other sensory neurons may suppress social feeding, as social feeding in ocr-2 and odr-4 mutants is restored by mutations in osm-3, a gene required for the development of 26 ciliated sensory neurons. Our data suggest a model for regulation of social feeding by opposing sensory inputs: aversive inputs to nociceptive neurons promote social feeding, whereas antagonistic inputs from neurons that express osm-3 inhibit aggregation.' author: - first_name: Mario full_name: de Bono, Mario id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87 last_name: de Bono orcid: 0000-0001-8347-0443 - first_name: David M. full_name: Tobin, David M. last_name: Tobin - first_name: M. Wayne full_name: Davis, M. Wayne last_name: Davis - first_name: Leon full_name: Avery, Leon last_name: Avery - first_name: Cornelia I. full_name: Bargmann, Cornelia I. last_name: Bargmann citation: ama: de Bono M, Tobin DM, Davis MW, Avery L, Bargmann CI. Social feeding in Caenorhabditis elegans is induced by neurons that detect aversive stimuli. Nature. 2002;419(6910):899-903. doi:10.1038/nature01169 apa: de Bono, M., Tobin, D. M., Davis, M. W., Avery, L., & Bargmann, C. I. (2002). Social feeding in Caenorhabditis elegans is induced by neurons that detect aversive stimuli. Nature. Springer Nature. https://doi.org/10.1038/nature01169 chicago: Bono, Mario de, David M. Tobin, M. Wayne Davis, Leon Avery, and Cornelia I. Bargmann. “Social Feeding in Caenorhabditis Elegans Is Induced by Neurons That Detect Aversive Stimuli.” Nature. Springer Nature, 2002. https://doi.org/10.1038/nature01169. ieee: M. de Bono, D. M. Tobin, M. W. Davis, L. Avery, and C. I. Bargmann, “Social feeding in Caenorhabditis elegans is induced by neurons that detect aversive stimuli,” Nature, vol. 419, no. 6910. Springer Nature, pp. 899–903, 2002. ista: de Bono M, Tobin DM, Davis MW, Avery L, Bargmann CI. 2002. Social feeding in Caenorhabditis elegans is induced by neurons that detect aversive stimuli. Nature. 419(6910), 899–903. mla: de Bono, Mario, et al. “Social Feeding in Caenorhabditis Elegans Is Induced by Neurons That Detect Aversive Stimuli.” Nature, vol. 419, no. 6910, Springer Nature, 2002, pp. 899–903, doi:10.1038/nature01169. short: M. de Bono, D.M. Tobin, M.W. Davis, L. Avery, C.I. Bargmann, Nature 419 (2002) 899–903. date_created: 2019-03-21T10:27:04Z date_published: 2002-10-31T00:00:00Z date_updated: 2021-01-12T08:06:27Z day: '31' doi: 10.1038/nature01169 extern: '1' external_id: pmid: - '12410303' intvolume: ' 419' issue: '6910' language: - iso: eng month: '10' oa_version: None page: 899-903 pmid: 1 publication: Nature publication_identifier: issn: - 0028-0836 publication_status: published publisher: Springer Nature quality_controlled: '1' status: public title: Social feeding in Caenorhabditis elegans is induced by neurons that detect aversive stimuli type: journal_article user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87 volume: 419 year: '2002' ... --- _id: '4631' abstract: - lang: eng text: We present a theory of timed interfaces, which is capable of specifying both the timing of the inputs a component expects from the environment, and the timing of the outputs it can produce. Two timed interfaces are compatible if there is a way to use them together such that their timing expectations are met. Our theory provides algorithms for checking the compatibility between two interfaces and for deriving the composite interface; the theory can thus be viewed as a type system for real-time interaction. Technically, a timed interface is encoded as a timed game between two players, representing the inputs and outputs of the component. The algorithms for compatibility checking and interface composition are thus derived from algorithms for solving timed games. acknowledgement: This research was supported in part by the NSF CAREER award CCR-0132780, the NSF grant CCR-9988172 the AFOSR MURI grant F49620-00-1-0327, the DARPA PCES grant F33615-00-C-1693, the MARCO GSRC grant 98-DT-660, and the ONR grant N00014-02-1-0671. alternative_title: - LNCS article_processing_charge: No author: - first_name: Luca full_name: De Alfaro, Luca last_name: De Alfaro - first_name: Thomas A full_name: Henzinger, Thomas A id: 40876CD8-F248-11E8-B48F-1D18A9856A87 last_name: Henzinger orcid: 0000−0002−2985−7724 - first_name: Mariëlle full_name: Stoelinga, Mariëlle last_name: Stoelinga citation: ama: 'De Alfaro L, Henzinger TA, Stoelinga M. Timed interfaces. In: Proceedings of the 2nd International Conference on Embedded Software. Vol 2491. ACM; 2002:108-122. doi:10.1007/3-540-45828-X_9' apa: 'De Alfaro, L., Henzinger, T. A., & Stoelinga, M. (2002). Timed interfaces. In Proceedings of the 2nd International Conference on Embedded Software (Vol. 2491, pp. 108–122). Grenoble, France: ACM. https://doi.org/10.1007/3-540-45828-X_9' chicago: De Alfaro, Luca, Thomas A Henzinger, and Mariëlle Stoelinga. “Timed Interfaces.” In Proceedings of the 2nd International Conference on Embedded Software, 2491:108–22. ACM, 2002. https://doi.org/10.1007/3-540-45828-X_9. ieee: L. De Alfaro, T. A. Henzinger, and M. Stoelinga, “Timed interfaces,” in Proceedings of the 2nd International Conference on Embedded Software, Grenoble, France, 2002, vol. 2491, pp. 108–122. ista: 'De Alfaro L, Henzinger TA, Stoelinga M. 2002. Timed interfaces. Proceedings of the 2nd International Conference on Embedded Software. EMSOFT: Embedded Software , LNCS, vol. 2491, 108–122.' mla: De Alfaro, Luca, et al. “Timed Interfaces.” Proceedings of the 2nd International Conference on Embedded Software, vol. 2491, ACM, 2002, pp. 108–22, doi:10.1007/3-540-45828-X_9. short: L. De Alfaro, T.A. Henzinger, M. Stoelinga, in:, Proceedings of the 2nd International Conference on Embedded Software, ACM, 2002, pp. 108–122. conference: end_date: 2002-10-09 location: Grenoble, France name: 'EMSOFT: Embedded Software ' start_date: 2002-10-07 date_created: 2018-12-11T12:09:51Z date_published: 2002-10-24T00:00:00Z date_updated: 2023-06-02T10:00:32Z day: '24' doi: 10.1007/3-540-45828-X_9 extern: '1' intvolume: ' 2491' language: - iso: eng month: '10' oa_version: None page: 108 - 122 publication: Proceedings of the 2nd International Conference on Embedded Software publication_identifier: isbn: - '9783540443070' publication_status: published publisher: ACM publist_id: '76' quality_controlled: '1' status: public title: Timed interfaces type: conference user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 2491 year: '2002' ... --- _id: '4562' abstract: - lang: eng text: We present interface models that describe both the input assumptions of a component, and its output behavior. By enabling us to check that the input assumptions of a component are met in a design, interface models provide a compatibility check for component-based design. When refining a design into an implementation, interface models require that the output behavior of a component satisfies the design specification only when the input assumptions of the specification are satisfied, yielding greater flexibility in the choice of implementations. Technically, our interface models are games between two players, Input and Output; the duality of the players accounts for the dual roles of inputs and outputs in composition and refinement. We present two interface models in detail, one for a simple synchronous form of interaction between components typical in hardware, and the other for more complex synchronous interactions on bidirectional connections. As an example, we specify the interface of a bidirectional bus, with the input assumption that at any time at most one component has write access to the bus. For these interface models, we present algorithms for compatibility and refinement checking, and we describe efficient symbolic implementations. acknowledgement: This research was supported in part by the AFOSR grant F49620-00-1-0327, the DARPA grant F33615-00-C-1693, the MARCO grant 98-DT-660, the NSF grant CCR-9988172, the SRC grant 99-TJ-683.003, and the NSF CAREER award CCR-0132780. alternative_title: - LNCS article_processing_charge: No author: - first_name: Arindam full_name: Chakrabarti, Arindam last_name: Chakrabarti - first_name: Luca full_name: De Alfaro, Luca last_name: De Alfaro - first_name: Thomas A full_name: Henzinger, Thomas A id: 40876CD8-F248-11E8-B48F-1D18A9856A87 last_name: Henzinger orcid: 0000−0002−2985−7724 - first_name: Freddy full_name: Mang, Freddy last_name: Mang citation: ama: 'Chakrabarti A, De Alfaro L, Henzinger TA, Mang F. Synchronous and bidirectional component interfaces. In: Proceedings of the 14th International Conference on Computer Aided Verification. Vol 2404. Springer; 2002:414-427. doi:10.1007/3-540-45657-0_34' apa: 'Chakrabarti, A., De Alfaro, L., Henzinger, T. A., & Mang, F. (2002). Synchronous and bidirectional component interfaces. In Proceedings of the 14th International Conference on Computer Aided Verification (Vol. 2404, pp. 414–427). Copenhagen, Denmark: Springer. https://doi.org/10.1007/3-540-45657-0_34' chicago: Chakrabarti, Arindam, Luca De Alfaro, Thomas A Henzinger, and Freddy Mang. “Synchronous and Bidirectional Component Interfaces.” In Proceedings of the 14th International Conference on Computer Aided Verification, 2404:414–27. Springer, 2002. https://doi.org/10.1007/3-540-45657-0_34. ieee: A. Chakrabarti, L. De Alfaro, T. A. Henzinger, and F. Mang, “Synchronous and bidirectional component interfaces,” in Proceedings of the 14th International Conference on Computer Aided Verification, Copenhagen, Denmark, 2002, vol. 2404, pp. 414–427. ista: 'Chakrabarti A, De Alfaro L, Henzinger TA, Mang F. 2002. Synchronous and bidirectional component interfaces. Proceedings of the 14th International Conference on Computer Aided Verification. CAV: Computer Aided Verification, LNCS, vol. 2404, 414–427.' mla: Chakrabarti, Arindam, et al. “Synchronous and Bidirectional Component Interfaces.” Proceedings of the 14th International Conference on Computer Aided Verification, vol. 2404, Springer, 2002, pp. 414–27, doi:10.1007/3-540-45657-0_34. short: A. Chakrabarti, L. De Alfaro, T.A. Henzinger, F. Mang, in:, Proceedings of the 14th International Conference on Computer Aided Verification, Springer, 2002, pp. 414–427. conference: end_date: 2002-07-31 location: Copenhagen, Denmark name: 'CAV: Computer Aided Verification' start_date: 2002-07-27 date_created: 2018-12-11T12:09:29Z date_published: 2002-06-19T00:00:00Z date_updated: 2023-06-02T12:01:22Z day: '19' doi: 10.1007/3-540-45657-0_34 extern: '1' intvolume: ' 2404' language: - iso: eng month: '06' oa_version: None page: 414 - 427 publication: Proceedings of the 14th International Conference on Computer Aided Verification publication_identifier: isbn: - '9783540439974' publication_status: published publisher: Springer publist_id: '146' quality_controlled: '1' scopus_import: '1' status: public title: Synchronous and bidirectional component interfaces type: conference user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 2404 year: '2002' ... --- _id: '4565' abstract: - lang: eng text: "In the literature, we find several formulations of the control\r\nproblem for timed and hybrid systems. We argue that formulations where\r\na controller can cause an action at any point in dense (rational or real)\r\ntime are problematic, by presenting an example where the controller\r\nmust act faster and faster, yet causes no Zeno effects (say, the control\r\nactions are at times 0, 1/2, 1, 1 1/4, 2, 2 1/8, 3, 3 1/16 ,...). Such a controller is,\r\nof course, not implementable in software. Such controllers are avoided by formulations where the controller can cause actions only at discrete (integer) points in time. While the resulting control problem is well- understood if the time unit, or “sampling rate” of the controller, is fixed a priori, we define a novel, stronger formulation: the discrete-time control problem with unknown sampling rate asks if a sampling controller exists for some sampling rate. We prove that this problem is undecidable even in the special case of timed automata." acknowledgement: "Partially supported by the FNRS, Belgium, under grant 1.5.096.01.\r\nPartially supported by the DARPA SEC grant F33615-C-98-3614, the AFOSR MURI grant F49620-00-1-0327, the NSF Theory grant CCR-9988172, and the MARCO GSRC grant 98-DT-660.\r\nPartially supported by a “Crédit aux chercheurs” from the Belgian National Fund for Scientific Research." alternative_title: - LNCS article_processing_charge: No author: - first_name: Franck full_name: Cassez, Franck last_name: Cassez - first_name: Thomas A full_name: Henzinger, Thomas A id: 40876CD8-F248-11E8-B48F-1D18A9856A87 last_name: Henzinger orcid: 0000−0002−2985−7724 - first_name: Jean full_name: Raskin, Jean last_name: Raskin citation: ama: 'Cassez F, Henzinger TA, Raskin J. A comparison of control problems for timed and hybrid systems. In: Proceedings of the 5th International Workshop on Hybrid Systems: Computation and Control. Vol 2289. Springer; 2002:134-148. doi:10.1007/3-540-45873-5_13' apa: 'Cassez, F., Henzinger, T. A., & Raskin, J. (2002). A comparison of control problems for timed and hybrid systems. In Proceedings of the 5th International Workshop on Hybrid Systems: Computation and Control (Vol. 2289, pp. 134–148). Stanford, CA, USA: Springer. https://doi.org/10.1007/3-540-45873-5_13' chicago: 'Cassez, Franck, Thomas A Henzinger, and Jean Raskin. “A Comparison of Control Problems for Timed and Hybrid Systems.” In Proceedings of the 5th International Workshop on Hybrid Systems: Computation and Control, 2289:134–48. Springer, 2002. https://doi.org/10.1007/3-540-45873-5_13.' ieee: 'F. Cassez, T. A. Henzinger, and J. Raskin, “A comparison of control problems for timed and hybrid systems,” in Proceedings of the 5th International Workshop on Hybrid Systems: Computation and Control, Stanford, CA, USA, 2002, vol. 2289, pp. 134–148.' ista: 'Cassez F, Henzinger TA, Raskin J. 2002. A comparison of control problems for timed and hybrid systems. Proceedings of the 5th International Workshop on Hybrid Systems: Computation and Control. HSCC: Hybrid Systems - Computation and Control, LNCS, vol. 2289, 134–148.' mla: 'Cassez, Franck, et al. “A Comparison of Control Problems for Timed and Hybrid Systems.” Proceedings of the 5th International Workshop on Hybrid Systems: Computation and Control, vol. 2289, Springer, 2002, pp. 134–48, doi:10.1007/3-540-45873-5_13.' short: 'F. Cassez, T.A. Henzinger, J. Raskin, in:, Proceedings of the 5th International Workshop on Hybrid Systems: Computation and Control, Springer, 2002, pp. 134–148.' conference: end_date: 2002-03-27 location: Stanford, CA, USA name: 'HSCC: Hybrid Systems - Computation and Control' start_date: 2002-03-25 date_created: 2018-12-11T12:09:30Z date_published: 2002-03-14T00:00:00Z date_updated: 2023-06-02T10:29:10Z day: '14' doi: 10.1007/3-540-45873-5_13 extern: '1' intvolume: ' 2289' language: - iso: eng month: '03' oa_version: None page: 134 - 148 publication: 'Proceedings of the 5th International Workshop on Hybrid Systems: Computation and Control' publication_identifier: isbn: - '9783540433217' publication_status: published publisher: Springer publist_id: '144' quality_controlled: '1' scopus_import: '1' status: public title: A comparison of control problems for timed and hybrid systems type: conference user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 2289 year: '2002' ... --- _id: '4595' abstract: - lang: eng text: 'Temporal logic comes in two varieties: linear-time temporal logic assumes implicit universal quantification over all paths that are generated by the execution of a system; branching-time temporal logic allows explicit existential and universal quantification over all paths. We introduce a third, more general variety of temporal logic: alternating-time temporal logic offers selective quantification over those paths that are possible outcomes of games, such as the game in which the system and the environment alternate moves. While linear-time and branching-time logics are natural specification languages for closed systems, alternating-time logics are natural specification languages for open systems. For example, by preceding the temporal operator "eventually" with a selective path quantifier, we can specify that in the game between the system and the environment, the system has a strategy to reach a certain state. The problems of receptiveness, realizability, and controllability can be formulated as model-checking problems for alternating-time formulas. Depending on whether or not we admit arbitrary nesting of selective path quantifiers and temporal operators, we obtain the two alternating-time temporal logics ATL and ATL*.ATL and ATL* are interpreted over concurrent game structures. Every state transition of a concurrent game structure results from a choice of moves, one for each player. The players represent individual components and the environment of an open system. Concurrent game structures can capture various forms of synchronous composition for open systems, and if augmented with fairness constraints, also asynchronous composition. Over structures without fairness constraints, the model-checking complexity of ATL is linear in the size of the game structure and length of the formula, and the symbolic model-checking algorithm for CTL extends with few modifications to ATL. Over structures with weak-fairness constraints, ATL model checking requires the solution of 1-pair Rabin games, and can be done in polynomial time. Over structures with strong-fairness constraints, ATL model checking requires the solution of games with Boolean combinations of Büchi conditions, and can be done in PSPACE. In the case of ATL*, the model-checking problem is closely related to the synthesis problem for linear-time formulas, and requires doubly exponential time.' acknowledgement: We thank Luca de Alfaro, Kousha Etessami, Salvatore La Torre, P. Madhusudan, Amir Pnueli, Moshe Vardi, Thomas Wilke, and Mihalis Yannakakis for helpful discussions. We also thank Freddy Mang for comments on a draft of this manuscript. article_processing_charge: No article_type: original author: - first_name: Rajeev full_name: Alur, Rajeev last_name: Alur - first_name: Thomas A full_name: Henzinger, Thomas A id: 40876CD8-F248-11E8-B48F-1D18A9856A87 last_name: Henzinger orcid: 0000−0002−2985−7724 - first_name: Orna full_name: Kupferman, Orna last_name: Kupferman citation: ama: Alur R, Henzinger TA, Kupferman O. Alternating-time temporal logic. Journal of the ACM. 2002;49(5):672-713. doi:10.1145/585265.585270 apa: Alur, R., Henzinger, T. A., & Kupferman, O. (2002). Alternating-time temporal logic. Journal of the ACM. ACM. https://doi.org/10.1145/585265.585270 chicago: Alur, Rajeev, Thomas A Henzinger, and Orna Kupferman. “Alternating-Time Temporal Logic.” Journal of the ACM. ACM, 2002. https://doi.org/10.1145/585265.585270. ieee: R. Alur, T. A. Henzinger, and O. Kupferman, “Alternating-time temporal logic,” Journal of the ACM, vol. 49, no. 5. ACM, pp. 672–713, 2002. ista: Alur R, Henzinger TA, Kupferman O. 2002. Alternating-time temporal logic. Journal of the ACM. 49(5), 672–713. mla: Alur, Rajeev, et al. “Alternating-Time Temporal Logic.” Journal of the ACM, vol. 49, no. 5, ACM, 2002, pp. 672–713, doi:10.1145/585265.585270. short: R. Alur, T.A. Henzinger, O. Kupferman, Journal of the ACM 49 (2002) 672–713. date_created: 2018-12-11T12:09:40Z date_published: 2002-09-01T00:00:00Z date_updated: 2023-06-02T10:07:22Z day: '01' doi: 10.1145/585265.585270 extern: '1' intvolume: ' 49' issue: '5' language: - iso: eng month: '09' oa_version: None page: 672 - 713 publication: Journal of the ACM publication_identifier: issn: - 0004-5411 publication_status: published publisher: ACM publist_id: '110' quality_controlled: '1' scopus_import: '1' status: public title: Alternating-time temporal logic type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 49 year: '2002' ... --- _id: '4471' abstract: - lang: eng text: The sequential synthesis problem, which is closely related to Church’s solvability problem, asks, given a specification in the form of a binary relation between input and output streams, for the construction of a finite-state stream transducer that converts inputs to appropriate outputs. For efficiency reasons, practical sequential hardware is often designed to operate without prior initialization. Such hardware designs can be modeled by uninitialized state machines, which are required to satisfy their specification if started from any state. In this paper we solve the sequential synthesis problem for uninitialized systems, that is, we construct uninitialized finite-state stream transducers. We consider specifications given by LTL formulas, deterministic, nondeterministic, universal, and alternating Büchi automata. We solve this uninitialized synthesis problem by reducing it to the well-understood initialized synthesis problem. While our solution is straightforward, it leads, for some specification formalisms, to upper bounds that are exponentially worse than the complexity of the corresponding initialized problems. However, we prove lower bounds to show that our simple solutions are optimal for all considered specification formalisms. We also study the problem of deciding whether a given specification is uninitialized, that is, if its uninitialized and initialized synthesis problems coincide. We show that this problem has, for each specification formalism, the same complexity as the equivalence problem. acknowledgement: This research was supported in part by the SRC contract 99-TJ-683.003, the DARPA contract NAG2-1214, and the NSF grant CCR-9988172. alternative_title: - LNCS article_processing_charge: No author: - first_name: Thomas A full_name: Henzinger, Thomas A id: 40876CD8-F248-11E8-B48F-1D18A9856A87 last_name: Henzinger orcid: 0000−0002−2985−7724 - first_name: Sriram full_name: Krishnan, Sriram last_name: Krishnan - first_name: Orna full_name: Kupferman, Orna last_name: Kupferman - first_name: Freddy full_name: Mang, Freddy last_name: Mang citation: ama: 'Henzinger TA, Krishnan S, Kupferman O, Mang F. Synthesis of uninitialized systems. In: Proceedings of the 29th International Colloquium on Automata, Languages and Programming. Vol 2380. Springer; 2002:644-656. doi:10.1007/3-540-45465-9_55' apa: 'Henzinger, T. A., Krishnan, S., Kupferman, O., & Mang, F. (2002). Synthesis of uninitialized systems. In Proceedings of the 29th International Colloquium on Automata, Languages and Programming (Vol. 2380, pp. 644–656). Malaga, Spain: Springer. https://doi.org/10.1007/3-540-45465-9_55' chicago: Henzinger, Thomas A, Sriram Krishnan, Orna Kupferman, and Freddy Mang. “Synthesis of Uninitialized Systems.” In Proceedings of the 29th International Colloquium on Automata, Languages and Programming, 2380:644–56. Springer, 2002. https://doi.org/10.1007/3-540-45465-9_55. ieee: T. A. Henzinger, S. Krishnan, O. Kupferman, and F. Mang, “Synthesis of uninitialized systems,” in Proceedings of the 29th International Colloquium on Automata, Languages and Programming, Malaga, Spain, 2002, vol. 2380, pp. 644–656. ista: 'Henzinger TA, Krishnan S, Kupferman O, Mang F. 2002. Synthesis of uninitialized systems. Proceedings of the 29th International Colloquium on Automata, Languages and Programming. ICALP: Automata, Languages and Programming, LNCS, vol. 2380, 644–656.' mla: Henzinger, Thomas A., et al. “Synthesis of Uninitialized Systems.” Proceedings of the 29th International Colloquium on Automata, Languages and Programming, vol. 2380, Springer, 2002, pp. 644–56, doi:10.1007/3-540-45465-9_55. short: T.A. Henzinger, S. Krishnan, O. Kupferman, F. Mang, in:, Proceedings of the 29th International Colloquium on Automata, Languages and Programming, Springer, 2002, pp. 644–656. conference: end_date: 2002-07-13 location: Malaga, Spain name: 'ICALP: Automata, Languages and Programming' start_date: 2002-07-08 date_created: 2018-12-11T12:09:01Z date_published: 2002-06-26T00:00:00Z date_updated: 2023-06-05T08:05:13Z day: '26' doi: 10.1007/3-540-45465-9_55 extern: '1' intvolume: ' 2380' language: - iso: eng month: '06' oa_version: None page: 644 - 656 publication: Proceedings of the 29th International Colloquium on Automata, Languages and Programming publication_identifier: isbn: - '9783540438649' publication_status: published publisher: Springer publist_id: '257' quality_controlled: '1' scopus_import: '1' status: public title: Synthesis of uninitialized systems type: conference user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 2380 year: '2002' ... --- _id: '4474' abstract: - lang: eng text: 'The simulation preorder for labeled transition systems is defined locally, and operationally, as a game that relates states with their immediate successor states. Simulation enjoys many appealing properties. First, simulation has a denotational characterization: system S simulates system I iff every computation tree embedded in the unrolling of I can be embedded also in the unrolling of S. Second, simulation has a logical characterization: S simulates I iff every universal branching-time formula satisfied by S is satisfied also by I. It follows that simulation is a suitable notion of implementation, and it is the coarsest abstraction of a system that preserves universal branching-time properties. Third, based on its local definition, simulation between finite-state systems can be checked in polynomial time. Finally, simulation implies trace containment, which cannot be defined locally and requires polynomial space for verification. Hence simulation is widely used both in manual and in automatic verification. Liveness assumptions about transition systems are typically modeled using fairness constraints. Existing notions of simulation for fair transition systems, however, are not local, and as a result, many appealing properties of the simulation preorder are lost. We propose a new view of fair simulation by extending the local definition of simulation to account for fairness: system View the MathML sourcefairly simulates system View the MathML source iff in the simulation game, there is a strategy that matches with each fair computation of View the MathML source a fair computation of View the MathML source. Our definition enjoys a denotational characterization and has a logical characterization: View the MathML source fairly simulates View the MathML source iff every fair computation tree (whose infinite paths are fair) embedded in the unrolling of View the MathML source can be embedded also in the unrolling of View the MathML source or, equivalently, iff every Fair-∀AFMC formula satisfied by View the MathML source is satisfied also by View the MathML source (∀AFMC is the universal fragment of the alternation-free μ-calculus). The locality of the definition leads us to a polynomial-time algorithm for checking fair simulation for finite-state systems with weak and strong fairness constraints. Finally, fair simulation implies fair trace containment and is therefore useful as an efficiently computable local criterion for proving linear-time abstraction hierarchies of fair systems.' acknowledgement: We thank Ramin Hojati, Doron Bustan, and the anonymous reviewers for their comments on this paper. article_processing_charge: No article_type: original author: - first_name: Thomas A full_name: Henzinger, Thomas A id: 40876CD8-F248-11E8-B48F-1D18A9856A87 last_name: Henzinger orcid: 0000−0002−2985−7724 - first_name: Orna full_name: Kupferman, Orna last_name: Kupferman - first_name: Sriram full_name: Rajamani, Sriram last_name: Rajamani citation: ama: Henzinger TA, Kupferman O, Rajamani S. Fair simulation. Information and Computation. 2002;173(1):64-81. doi:10.1006/inco.2001.3085 apa: Henzinger, T. A., Kupferman, O., & Rajamani, S. (2002). Fair simulation. Information and Computation. Elsevier. https://doi.org/10.1006/inco.2001.3085 chicago: Henzinger, Thomas A, Orna Kupferman, and Sriram Rajamani. “Fair Simulation.” Information and Computation. Elsevier, 2002. https://doi.org/10.1006/inco.2001.3085. ieee: T. A. Henzinger, O. Kupferman, and S. Rajamani, “Fair simulation,” Information and Computation, vol. 173, no. 1. Elsevier, pp. 64–81, 2002. ista: Henzinger TA, Kupferman O, Rajamani S. 2002. Fair simulation. Information and Computation. 173(1), 64–81. mla: Henzinger, Thomas A., et al. “Fair Simulation.” Information and Computation, vol. 173, no. 1, Elsevier, 2002, pp. 64–81, doi:10.1006/inco.2001.3085. short: T.A. Henzinger, O. Kupferman, S. Rajamani, Information and Computation 173 (2002) 64–81. date_created: 2018-12-11T12:09:02Z date_published: 2002-02-25T00:00:00Z date_updated: 2023-06-05T07:53:27Z day: '25' doi: 10.1006/inco.2001.3085 extern: '1' intvolume: ' 173' issue: '1' language: - iso: eng main_file_link: - open_access: '1' url: https://www.sciencedirect.com/science/article/pii/S0890540101930858?via%3Dihub month: '02' oa: 1 oa_version: Published Version page: 64 - 81 publication: Information and Computation publication_identifier: issn: - 0890-5401 publication_status: published publisher: Elsevier publist_id: '255' quality_controlled: '1' scopus_import: '1' status: public title: Fair simulation type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 173 year: '2002' ... --- _id: '4563' abstract: - lang: eng text: We present a formal methodology and tool for uncovering errors in the interaction of software modules. Our methodology consists of a suite of languages for defining software interfaces, and algorithms for checking interface compatibility. We focus on interfaces that explain the method-call dependencies between software modules. Such an interface makes assumptions about the environment in the form of call and availability constraints. A call constraint restricts the accessibility of local methods to certain external methods. An availability constraint restricts the accessibility of local methods to certain states of the module. For example, the interface for a file server with local methods open and read may assert that a file cannot be read without having been opened. Checking interface compatibility requires the solution of games, and in the presence of availability constraints, of pushdown games. Based on this methodology, we have implemented a tool that has uncovered incompatibilities in TinyOS, a small operating system for sensor nodes in adhoc networks. acknowledgement: This research was supported in part by the AFOSR grant F49620-00-1-0327, the DARPA grant F33615-00-C-1693, the MARCO grant 98-DT-660, the NSF grants CCR-9988172, CCR-0085949, CCR-0132780, the SRC grant 99-TJ-683, and the Polish KBN grant 7-T11C-027-20. alternative_title: - LNCS article_processing_charge: No author: - first_name: Arindam full_name: Chakrabarti, Arindam last_name: Chakrabarti - first_name: Luca full_name: De Alfaro, Luca last_name: De Alfaro - first_name: Thomas A full_name: Henzinger, Thomas A id: 40876CD8-F248-11E8-B48F-1D18A9856A87 last_name: Henzinger orcid: 0000−0002−2985−7724 - first_name: Marcin full_name: Jurdziński, Marcin last_name: Jurdziński - first_name: Freddy full_name: Mang, Freddy last_name: Mang citation: ama: 'Chakrabarti A, De Alfaro L, Henzinger TA, Jurdziński M, Mang F. Interface compatibility checking for software modules. In: Proceedings of the 14th International Conference on Computer Aided Verification. Vol 2404. Springer; 2002:428-441. doi:10.1007/3-540-45657-0_35' apa: 'Chakrabarti, A., De Alfaro, L., Henzinger, T. A., Jurdziński, M., & Mang, F. (2002). Interface compatibility checking for software modules. In Proceedings of the 14th International Conference on Computer Aided Verification (Vol. 2404, pp. 428–441). Copenhagen, Denmark: Springer. https://doi.org/10.1007/3-540-45657-0_35' chicago: Chakrabarti, Arindam, Luca De Alfaro, Thomas A Henzinger, Marcin Jurdziński, and Freddy Mang. “Interface Compatibility Checking for Software Modules.” In Proceedings of the 14th International Conference on Computer Aided Verification, 2404:428–41. Springer, 2002. https://doi.org/10.1007/3-540-45657-0_35. ieee: A. Chakrabarti, L. De Alfaro, T. A. Henzinger, M. Jurdziński, and F. Mang, “Interface compatibility checking for software modules,” in Proceedings of the 14th International Conference on Computer Aided Verification, Copenhagen, Denmark, 2002, vol. 2404, pp. 428–441. ista: 'Chakrabarti A, De Alfaro L, Henzinger TA, Jurdziński M, Mang F. 2002. Interface compatibility checking for software modules. Proceedings of the 14th International Conference on Computer Aided Verification. CAV: Computer Aided Verification, LNCS, vol. 2404, 428–441.' mla: Chakrabarti, Arindam, et al. “Interface Compatibility Checking for Software Modules.” Proceedings of the 14th International Conference on Computer Aided Verification, vol. 2404, Springer, 2002, pp. 428–41, doi:10.1007/3-540-45657-0_35. short: A. Chakrabarti, L. De Alfaro, T.A. Henzinger, M. Jurdziński, F. Mang, in:, Proceedings of the 14th International Conference on Computer Aided Verification, Springer, 2002, pp. 428–441. conference: end_date: 2002-07-31 location: Copenhagen, Denmark name: 'CAV: Computer Aided Verification' start_date: 2002-07-27 date_created: 2018-12-11T12:09:30Z date_published: 2002-06-19T00:00:00Z date_updated: 2023-06-05T07:38:10Z day: '19' doi: 10.1007/3-540-45657-0_35 extern: '1' intvolume: ' 2404' language: - iso: eng month: '06' oa_version: None page: 428 - 441 publication: Proceedings of the 14th International Conference on Computer Aided Verification publication_identifier: isbn: - ' 9783540439974' publication_status: published publisher: Springer publist_id: '147' quality_controlled: '1' scopus_import: '1' status: public title: Interface compatibility checking for software modules type: conference user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 2404 year: '2002' ... --- _id: '4472' abstract: - lang: eng text: 'We present a methodology and tool for verifying and certifying systems code. The verification is based on the lazy-abstraction paradigm for intertwining the following three logical steps: construct a predicate abstraction from the code, model check the abstraction, and automatically refine the abstraction based on counterexample analysis. The certification is based on the proof-carrying code paradigm. Lazy abstraction enables the automatic construction of small proof certificates. The methodology is implemented in Blast, the Berkeley Lazy Abstraction Software verification Tool. We describe our experience applying Blast to Linux and Windows device drivers. Given the C code for a driver and for a temporal-safety monitor, Blast automatically generates an easily checkable correctness certificate if the driver satisfies the specification, and an error trace otherwise.' acknowledgement: This work was supported in part by the NSF ITR grants CCR-0085949, CCR-0081588, the NSF Career grant CCR-9875171, the DARPA PCES grant F33615-00-C-1693, the MARCO GSRC grant 98-DT-660, the SRC contract 99-TJ-683, a Microsoft fellowship, and gifts from AT&T Research and Microsoft Research. alternative_title: - LNCS article_processing_charge: No author: - first_name: Thomas A full_name: Henzinger, Thomas A id: 40876CD8-F248-11E8-B48F-1D18A9856A87 last_name: Henzinger orcid: 0000−0002−2985−7724 - first_name: George full_name: Necula, George last_name: Necula - first_name: Ranjit full_name: Jhala, Ranjit last_name: Jhala - first_name: Grégoire full_name: Sutre, Grégoire last_name: Sutre - first_name: Ritankar full_name: Majumdar, Ritankar last_name: Majumdar - first_name: Westley full_name: Weimer, Westley last_name: Weimer citation: ama: 'Henzinger TA, Necula G, Jhala R, Sutre G, Majumdar R, Weimer W. Temporal safety proofs for systems code. In: Proceedings of the 14th International Conference on Computer Aided Verification. Vol 2404. Springer; 2002:526-538. doi:10.1007/3-540-45657-0_45' apa: 'Henzinger, T. A., Necula, G., Jhala, R., Sutre, G., Majumdar, R., & Weimer, W. (2002). Temporal safety proofs for systems code. In Proceedings of the 14th International Conference on Computer Aided Verification (Vol. 2404, pp. 526–538). Copenhagen, Denmark: Springer. https://doi.org/10.1007/3-540-45657-0_45' chicago: Henzinger, Thomas A, George Necula, Ranjit Jhala, Grégoire Sutre, Ritankar Majumdar, and Westley Weimer. “Temporal Safety Proofs for Systems Code.” In Proceedings of the 14th International Conference on Computer Aided Verification, 2404:526–38. Springer, 2002. https://doi.org/10.1007/3-540-45657-0_45. ieee: T. A. Henzinger, G. Necula, R. Jhala, G. Sutre, R. Majumdar, and W. Weimer, “Temporal safety proofs for systems code,” in Proceedings of the 14th International Conference on Computer Aided Verification, Copenhagen, Denmark, 2002, vol. 2404, pp. 526–538. ista: 'Henzinger TA, Necula G, Jhala R, Sutre G, Majumdar R, Weimer W. 2002. Temporal safety proofs for systems code. Proceedings of the 14th International Conference on Computer Aided Verification. CAV: Computer Aided Verification, LNCS, vol. 2404, 526–538.' mla: Henzinger, Thomas A., et al. “Temporal Safety Proofs for Systems Code.” Proceedings of the 14th International Conference on Computer Aided Verification, vol. 2404, Springer, 2002, pp. 526–38, doi:10.1007/3-540-45657-0_45. short: T.A. Henzinger, G. Necula, R. Jhala, G. Sutre, R. Majumdar, W. Weimer, in:, Proceedings of the 14th International Conference on Computer Aided Verification, Springer, 2002, pp. 526–538. conference: end_date: 2002-07-31 location: Copenhagen, Denmark name: 'CAV: Computer Aided Verification' start_date: 2002-07-27 date_created: 2018-12-11T12:09:01Z date_published: 2002-06-19T00:00:00Z date_updated: 2023-06-05T08:11:32Z day: '19' doi: 10.1007/3-540-45657-0_45 extern: '1' intvolume: ' 2404' language: - iso: eng month: '06' oa_version: None page: 526 - 538 publication: Proceedings of the 14th International Conference on Computer Aided Verification publication_identifier: isbn: - '9783540439974' publication_status: published publisher: Springer publist_id: '258' quality_controlled: '1' scopus_import: '1' status: public title: Temporal safety proofs for systems code type: conference user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 2404 year: '2002' ... --- _id: '4470' abstract: - lang: eng text: Giotto is a platform-independent language for specifying software for high-performance control applications. In this paper we present a new approach to the compilation of Giotto. Following this approach, the Giotto compiler generates code for a virtual machine, called the E machine, which can be ported to different platforms. The Giotto compiler also checks if the generated E code is time safe for a given platform, that is, if the platform offers sufficient performance to ensure that the E code is executed in a timely fashion that conforms with the Giotto semantics. Time-safety checking requires a schedulability analysis. We show that while for arbitrary E code, the analysis is exponential, for E code generated from typical Giotto programs, the analysis is polynomial. This supports our claim that Giotto identifies a useful fragment of embedded programs. acknowledgement: Supported in part by the DARPA SEC grant F33615-C-98-3614, MARCO GSRC grant 98-DT-660, AFOSR MURI grant F49620-00-1-0327, NSF grant CCR-9988172, and a Microsoft Research Fellowship. alternative_title: - LNCS article_processing_charge: No author: - first_name: Thomas A full_name: Henzinger, Thomas A id: 40876CD8-F248-11E8-B48F-1D18A9856A87 last_name: Henzinger orcid: 0000−0002−2985−7724 - first_name: Christoph full_name: Kirsch, Christoph last_name: Kirsch - first_name: Ritankar full_name: Majumdar, Ritankar last_name: Majumdar - first_name: Slobodan full_name: Matic, Slobodan last_name: Matic citation: ama: 'Henzinger TA, Kirsch C, Majumdar R, Matic S. Time-safety checking for embedded programs. In: Proceedings of the 2nd International Conference on Embedded Software. Vol 2491. ACM; 2002:76-92. doi:10.1007/3-540-45828-X_7' apa: 'Henzinger, T. A., Kirsch, C., Majumdar, R., & Matic, S. (2002). Time-safety checking for embedded programs. In Proceedings of the 2nd International Conference on Embedded Software (Vol. 2491, pp. 76–92). Grenoble, France: ACM. https://doi.org/10.1007/3-540-45828-X_7' chicago: Henzinger, Thomas A, Christoph Kirsch, Ritankar Majumdar, and Slobodan Matic. “Time-Safety Checking for Embedded Programs.” In Proceedings of the 2nd International Conference on Embedded Software, 2491:76–92. ACM, 2002. https://doi.org/10.1007/3-540-45828-X_7. ieee: T. A. Henzinger, C. Kirsch, R. Majumdar, and S. Matic, “Time-safety checking for embedded programs,” in Proceedings of the 2nd International Conference on Embedded Software, Grenoble, France, 2002, vol. 2491, pp. 76–92. ista: 'Henzinger TA, Kirsch C, Majumdar R, Matic S. 2002. Time-safety checking for embedded programs. Proceedings of the 2nd International Conference on Embedded Software. EMSOFT: Embedded Software , LNCS, vol. 2491, 76–92.' mla: Henzinger, Thomas A., et al. “Time-Safety Checking for Embedded Programs.” Proceedings of the 2nd International Conference on Embedded Software, vol. 2491, ACM, 2002, pp. 76–92, doi:10.1007/3-540-45828-X_7. short: T.A. Henzinger, C. Kirsch, R. Majumdar, S. Matic, in:, Proceedings of the 2nd International Conference on Embedded Software, ACM, 2002, pp. 76–92. conference: end_date: 2002-10-09 location: Grenoble, France name: 'EMSOFT: Embedded Software ' start_date: 2002-10-07 date_created: 2018-12-11T12:09:01Z date_published: 2002-09-25T00:00:00Z date_updated: 2023-06-05T08:50:59Z day: '25' doi: 10.1007/3-540-45828-X_7 extern: '1' intvolume: ' 2491' language: - iso: eng month: '09' oa_version: None page: 76 - 92 publication: Proceedings of the 2nd International Conference on Embedded Software publication_identifier: isbn: - '9783540443070' publication_status: published publisher: ACM publist_id: '259' quality_controlled: '1' scopus_import: '1' status: public title: Time-safety checking for embedded programs type: conference user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 2491 year: '2002' ... --- _id: '4444' abstract: - lang: eng text: The Embedded Machine is a virtual machine that mediates in real time the interaction between software processes and physical processes. It separates the compilation of embedded programs into two phases. The first, platform-independent compiler phase generates E code (code executed by the Embedded Machine), which supervises the timing ---not the scheduling--- of application tasks relative to external events, such as clock ticks and sensor interrupts. E~code is portable and exhibits, given an input behavior, predictable (i.e., deterministic) timing and output behavior. The second, platform-dependent compiler phase checks the time safety of the E code, that is, whether platform performance (determined by the hardware) and platform utilization (determined by the scheduler of the operating system) enable its timely execution. We have used the Embedded Machine to compile and execute high-performance control applications written in Giotto, such as the flight control system of an autonomous model helicopter. acknowledgement: This research was supported in part by the DARPA SEC grant F33615-C-98-3614, the MARCO GSRC grant 98-DT- 660, the AFOSR MURI grant F49620-00-1-0327, and the NSF ITR grant CCR-0085949. article_processing_charge: No author: - first_name: Thomas A full_name: Henzinger, Thomas A id: 40876CD8-F248-11E8-B48F-1D18A9856A87 last_name: Henzinger orcid: 0000−0002−2985−7724 - first_name: Christoph full_name: Kirsch, Christoph last_name: Kirsch citation: ama: 'Henzinger TA, Kirsch C. The embedded machine: predictable, portable real-time code. In: Proceedings of the ACM SIGPLAN 2002 Conference on Programming Language Design and Implementation. ACM; 2002:315-326. doi:10.1145/512529.512567' apa: 'Henzinger, T. A., & Kirsch, C. (2002). The embedded machine: predictable, portable real-time code. In Proceedings of the ACM SIGPLAN 2002 conference on Programming language design and implementation (pp. 315–326). Berlin, Germany: ACM. https://doi.org/10.1145/512529.512567' chicago: 'Henzinger, Thomas A, and Christoph Kirsch. “The Embedded Machine: Predictable, Portable Real-Time Code.” In Proceedings of the ACM SIGPLAN 2002 Conference on Programming Language Design and Implementation, 315–26. ACM, 2002. https://doi.org/10.1145/512529.512567.' ieee: 'T. A. Henzinger and C. Kirsch, “The embedded machine: predictable, portable real-time code,” in Proceedings of the ACM SIGPLAN 2002 conference on Programming language design and implementation, Berlin, Germany, 2002, pp. 315–326.' ista: 'Henzinger TA, Kirsch C. 2002. The embedded machine: predictable, portable real-time code. Proceedings of the ACM SIGPLAN 2002 conference on Programming language design and implementation. PLDI: Programming Languages Design and Implementation, 315–326.' mla: 'Henzinger, Thomas A., and Christoph Kirsch. “The Embedded Machine: Predictable, Portable Real-Time Code.” Proceedings of the ACM SIGPLAN 2002 Conference on Programming Language Design and Implementation, ACM, 2002, pp. 315–26, doi:10.1145/512529.512567.' short: T.A. Henzinger, C. Kirsch, in:, Proceedings of the ACM SIGPLAN 2002 Conference on Programming Language Design and Implementation, ACM, 2002, pp. 315–326. conference: end_date: 2002-06-19 location: Berlin, Germany name: 'PLDI: Programming Languages Design and Implementation' start_date: 2002-06-17 date_created: 2018-12-11T12:08:53Z date_published: 2002-06-01T00:00:00Z date_updated: 2023-06-05T09:02:23Z day: '01' doi: 10.1145/512529.512567 extern: '1' language: - iso: eng month: '06' oa_version: None page: 315 - 326 publication: Proceedings of the ACM SIGPLAN 2002 conference on Programming language design and implementation publication_identifier: isbn: - '9781581134636' publication_status: published publisher: ACM publist_id: '284' quality_controlled: '1' scopus_import: '1' status: public title: 'The embedded machine: predictable, portable real-time code' type: conference user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 year: '2002' ... --- _id: '4476' abstract: - lang: eng text: 'One approach to model checking software is based on the abstract-check-refine paradigm: build an abstract model, then check the desired property, and if the check fails, refine the model and start over. We introduce the concept of lazy abstraction to integrate and optimize the three phases of the abstract-check-refine loop. Lazy abstraction continuously builds and refines a single abstract model on demand, driven by the model checker, so that different parts of the model may exhibit different degrees of precision, namely just enough to verify the desired property. We present an algorithm for model checking safety properties using lazy abstraction and describe an implementation of the algorithm applied to C programs. We also provide sufficient conditions for the termination of the method.' acknowledgement: "We thank Wes Weimer and Jeff Foster for many useful discussions. \r\n" article_processing_charge: No author: - first_name: Thomas A full_name: Henzinger, Thomas A id: 40876CD8-F248-11E8-B48F-1D18A9856A87 last_name: Henzinger orcid: 0000−0002−2985−7724 - first_name: Ranjit full_name: Jhala, Ranjit last_name: Jhala - first_name: Ritankar full_name: Majumdar, Ritankar last_name: Majumdar - first_name: Grégoire full_name: Sutre, Grégoire last_name: Sutre citation: ama: 'Henzinger TA, Jhala R, Majumdar R, Sutre G. Lazy abstraction. In: Proceedings of the 29th ACM SIGPLAN-SIGACT Symposium on Principles of Programming Languages. ACM; 2002:58-70. doi:10.1145/503272.503279' apa: 'Henzinger, T. A., Jhala, R., Majumdar, R., & Sutre, G. (2002). Lazy abstraction. In Proceedings of the 29th ACM SIGPLAN-SIGACT symposium on Principles of programming languages (pp. 58–70). Portland, OR, USA: ACM. https://doi.org/10.1145/503272.503279' chicago: Henzinger, Thomas A, Ranjit Jhala, Ritankar Majumdar, and Grégoire Sutre. “Lazy Abstraction.” In Proceedings of the 29th ACM SIGPLAN-SIGACT Symposium on Principles of Programming Languages, 58–70. ACM, 2002. https://doi.org/10.1145/503272.503279. ieee: T. A. Henzinger, R. Jhala, R. Majumdar, and G. Sutre, “Lazy abstraction,” in Proceedings of the 29th ACM SIGPLAN-SIGACT symposium on Principles of programming languages, Portland, OR, USA, 2002, pp. 58–70. ista: 'Henzinger TA, Jhala R, Majumdar R, Sutre G. 2002. Lazy abstraction. Proceedings of the 29th ACM SIGPLAN-SIGACT symposium on Principles of programming languages. POPL: Principles of Programming Languages, 58–70.' mla: Henzinger, Thomas A., et al. “Lazy Abstraction.” Proceedings of the 29th ACM SIGPLAN-SIGACT Symposium on Principles of Programming Languages, ACM, 2002, pp. 58–70, doi:10.1145/503272.503279. short: T.A. Henzinger, R. Jhala, R. Majumdar, G. Sutre, in:, Proceedings of the 29th ACM SIGPLAN-SIGACT Symposium on Principles of Programming Languages, ACM, 2002, pp. 58–70. conference: end_date: 2002-01-18 location: Portland, OR, USA name: 'POPL: Principles of Programming Languages' start_date: 2002-01-16 date_created: 2018-12-11T12:09:03Z date_published: 2002-01-01T00:00:00Z date_updated: 2023-06-05T07:45:53Z day: '01' doi: 10.1145/503272.503279 extern: '1' language: - iso: eng month: '01' oa_version: None page: 58 - 70 publication: Proceedings of the 29th ACM SIGPLAN-SIGACT symposium on Principles of programming languages publication_identifier: isbn: - '9781581134506' publication_status: published publisher: ACM publist_id: '254' quality_controlled: '1' scopus_import: '1' status: public title: Lazy abstraction type: conference user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 year: '2002' ... --- _id: '4473' abstract: - lang: eng text: 'The simulation preorder on state transition systems is widely accepted as a useful notion of refinement, both in its own right and as an efficiently checkable sufficient condition for trace containment. For composite systems, due to the exponential explosion of the state space, there is a need for decomposing a simulation check of the form P ≤s Q, denoting "P is simulated by Q," into simpler simulation checks on the components of P and Q. We present an assume-guarantee rule that enables such a decomposition. To the best of our knowledge, this is the first assume-guarantee rule that applies to a refinement relation different from trace containment. Our rule is circular, and its soundness proof requires induction on trace trees. The proof is constructive: given simulation relations that witness the simulation preorder between corresponding components of P and Q, we provide a procedure for constructing a witness relation for P ≤s Q. We also extend our assume-guarantee rule to account for fairness constraints on transition systems.' article_processing_charge: No article_type: original author: - first_name: Thomas A full_name: Henzinger, Thomas A id: 40876CD8-F248-11E8-B48F-1D18A9856A87 last_name: Henzinger orcid: 0000−0002−2985−7724 - first_name: Shaz full_name: Qadeer, Shaz last_name: Qadeer - first_name: Sriram full_name: Rajamani, Sriram last_name: Rajamani - first_name: Serdar full_name: Tasiran, Serdar last_name: Tasiran citation: ama: Henzinger TA, Qadeer S, Rajamani S, Tasiran S. An assume-guarantee rule for checking simulation. ACM Transactions on Programming Languages and Systems (TOPLAS). 2002;24(1):51-64. doi:10.1145/509705.509707 apa: Henzinger, T. A., Qadeer, S., Rajamani, S., & Tasiran, S. (2002). An assume-guarantee rule for checking simulation. ACM Transactions on Programming Languages and Systems (TOPLAS). ACM. https://doi.org/10.1145/509705.509707 chicago: Henzinger, Thomas A, Shaz Qadeer, Sriram Rajamani, and Serdar Tasiran. “An Assume-Guarantee Rule for Checking Simulation.” ACM Transactions on Programming Languages and Systems (TOPLAS). ACM, 2002. https://doi.org/10.1145/509705.509707. ieee: T. A. Henzinger, S. Qadeer, S. Rajamani, and S. Tasiran, “An assume-guarantee rule for checking simulation,” ACM Transactions on Programming Languages and Systems (TOPLAS), vol. 24, no. 1. ACM, pp. 51–64, 2002. ista: Henzinger TA, Qadeer S, Rajamani S, Tasiran S. 2002. An assume-guarantee rule for checking simulation. ACM Transactions on Programming Languages and Systems (TOPLAS). 24(1), 51–64. mla: Henzinger, Thomas A., et al. “An Assume-Guarantee Rule for Checking Simulation.” ACM Transactions on Programming Languages and Systems (TOPLAS), vol. 24, no. 1, ACM, 2002, pp. 51–64, doi:10.1145/509705.509707. short: T.A. Henzinger, S. Qadeer, S. Rajamani, S. Tasiran, ACM Transactions on Programming Languages and Systems (TOPLAS) 24 (2002) 51–64. date_created: 2018-12-11T12:09:02Z date_published: 2002-01-01T00:00:00Z date_updated: 2023-06-05T07:59:47Z day: '01' doi: 10.1145/509705.509707 extern: '1' intvolume: ' 24' issue: '1' language: - iso: eng month: '01' oa_version: None page: 51 - 64 publication: ACM Transactions on Programming Languages and Systems (TOPLAS) publication_identifier: issn: - 0164-0925 publication_status: published publisher: ACM publist_id: '256' quality_controlled: '1' scopus_import: '1' status: public title: An assume-guarantee rule for checking simulation type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 24 year: '2002' ... --- _id: '4423' abstract: - lang: eng text: Automation control systems typically incorporate legacy code and components that were originally designed to operate independently. Furthermore, they operate under stringent safety and timing constraints. Current design strategies deal with these requirements and characteristics with ad hoc approaches. In particular, when designing control laws, implementation constraints are often ignored or cursorily estimated. Indeed, costly redesigns are needed after a prototype of the control system is built due to missed timing constraints and subtle transient errors. In this paper, we use the concepts of platform-based design, and the Giotto programming language, to develop a methodology for the design of automation control systems that builds in modularity and correct-by-construction procedures. We illustrate our strategy by describing the (successful) application of the methodology to the design of a time-based control system for a rotorcraft Uninhabited Aerial Vehicle (UAV). acknowledgement: "Research supported in part by DARPA under contract no.F33615-98-C-3614, Software Enabled Control, administered by\r\nAFRL, Dayton OH." article_processing_charge: No author: - first_name: Benjamin full_name: Horowitz, Benjamin last_name: Horowitz - first_name: Judith full_name: Liebman, Judith last_name: Liebman - first_name: Cedric full_name: Ma, Cedric last_name: Ma - first_name: T John full_name: Koo, T John last_name: Koo - first_name: Thomas A full_name: Henzinger, Thomas A id: 40876CD8-F248-11E8-B48F-1D18A9856A87 last_name: Henzinger orcid: 0000−0002−2985−7724 - first_name: Alberto full_name: Sangiovanni Vincentelli, Alberto last_name: Sangiovanni Vincentelli - first_name: Shankar full_name: Sastry, Shankar last_name: Sastry citation: ama: 'Horowitz B, Liebman J, Ma C, et al. Embedded software design and system integration for rotorcraft UAV using platforms. In: Proceedings of the 15th Triennial World Congress of the International Federation of Automatic Control. Vol 15. Elsevier; 2002. doi:10.3182/20020721-6-ES-1901.01628' apa: 'Horowitz, B., Liebman, J., Ma, C., Koo, T. J., Henzinger, T. A., Sangiovanni Vincentelli, A., & Sastry, S. (2002). Embedded software design and system integration for rotorcraft UAV using platforms. In Proceedings of the 15th Triennial World Congress of the International Federation of Automatic Control (Vol. 15). Barcelona, Spain: Elsevier. https://doi.org/10.3182/20020721-6-ES-1901.01628' chicago: Horowitz, Benjamin, Judith Liebman, Cedric Ma, T John Koo, Thomas A Henzinger, Alberto Sangiovanni Vincentelli, and Shankar Sastry. “Embedded Software Design and System Integration for Rotorcraft UAV Using Platforms.” In Proceedings of the 15th Triennial World Congress of the International Federation of Automatic Control, Vol. 15. Elsevier, 2002. https://doi.org/10.3182/20020721-6-ES-1901.01628. ieee: B. Horowitz et al., “Embedded software design and system integration for rotorcraft UAV using platforms,” in Proceedings of the 15th Triennial World Congress of the International Federation of Automatic Control, Barcelona, Spain, 2002, vol. 15, no. 1. ista: 'Horowitz B, Liebman J, Ma C, Koo TJ, Henzinger TA, Sangiovanni Vincentelli A, Sastry S. 2002. Embedded software design and system integration for rotorcraft UAV using platforms. Proceedings of the 15th Triennial World Congress of the International Federation of Automatic Control. IFAC: World Congress on Automatic Control vol. 15.' mla: Horowitz, Benjamin, et al. “Embedded Software Design and System Integration for Rotorcraft UAV Using Platforms.” Proceedings of the 15th Triennial World Congress of the International Federation of Automatic Control, vol. 15, no. 1, Elsevier, 2002, doi:10.3182/20020721-6-ES-1901.01628. short: B. Horowitz, J. Liebman, C. Ma, T.J. Koo, T.A. Henzinger, A. Sangiovanni Vincentelli, S. Sastry, in:, Proceedings of the 15th Triennial World Congress of the International Federation of Automatic Control, Elsevier, 2002. conference: end_date: 2002-07-26 location: Barcelona, Spain name: 'IFAC: World Congress on Automatic Control' start_date: 2002-07-21 date_created: 2018-12-11T12:08:47Z date_published: 2002-07-01T00:00:00Z date_updated: 2023-06-05T09:55:10Z day: '01' doi: 10.3182/20020721-6-ES-1901.01628 extern: '1' intvolume: ' 15' issue: '1' language: - iso: eng month: '07' oa_version: None publication: Proceedings of the 15th Triennial World Congress of the International Federation of Automatic Control publication_identifier: issn: - 1474-6670 publication_status: published publisher: Elsevier publist_id: '306' quality_controlled: '1' scopus_import: '1' status: public title: Embedded software design and system integration for rotorcraft UAV using platforms type: conference user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 15 year: '2002' ... --- _id: '4421' abstract: - lang: eng text: We demonstrate the feasibility and benefits of Giotto-based control software development by reimplementing the autopilot system of an autonomously flying model helicopter. Giotto offers a clean separation between the platform-independent concerns of software functionality and I/O timing, and the platform-dependent concerns of software scheduling and execution. Functionality code such as code computing control laws can be generated automatically from Simulink models or, as in the case of this project, inherited from a legacy system. I/O timing code is generated automatically from Giotto models that specify real-time requirements such as task frequencies and actuator update rates. We extend Simulink to support the design of Giotto models, and from these models, the automatic generation of Giotto code that supervises the interaction of the functionality code with the physical environment. The Giotto compiler performs a schedulability analysis on the Giotto code, and generates timing code for the helicopter platform. The Giotto methodology guarantees the stringent hard real-time requirements of the autopilot system, and at the same time supports the automation of the software development process in a way that produces a transparent software architecture with predictable behavior and reusable components. acknowledgement: This research was supported in part by the DARPA SEC grant F33615-C-98-3614, the MARCO GSRC grant 98-DT-660, and the AFOSR MURI grant F49620-00-1-0327. alternative_title: - LNCS article_processing_charge: No author: - first_name: Christoph full_name: Kirsch, Christoph last_name: Kirsch - first_name: Marco full_name: Sanvido, Marco last_name: Sanvido - first_name: Thomas A full_name: Henzinger, Thomas A id: 40876CD8-F248-11E8-B48F-1D18A9856A87 last_name: Henzinger orcid: 0000−0002−2985−7724 - first_name: Wolfgang full_name: Pree, Wolfgang last_name: Pree citation: ama: 'Kirsch C, Sanvido M, Henzinger TA, Pree W. A Giotto-based helicopter control system. In: Proceedings of the 2nd International Conference on Embedded Software. Vol 2491. ACM; 2002:46-60. doi:10.1007/3-540-45828-X_5' apa: 'Kirsch, C., Sanvido, M., Henzinger, T. A., & Pree, W. (2002). A Giotto-based helicopter control system. In Proceedings of the 2nd International Conference on Embedded Software (Vol. 2491, pp. 46–60). Grenoble, France: ACM. https://doi.org/10.1007/3-540-45828-X_5' chicago: Kirsch, Christoph, Marco Sanvido, Thomas A Henzinger, and Wolfgang Pree. “A Giotto-Based Helicopter Control System.” In Proceedings of the 2nd International Conference on Embedded Software, 2491:46–60. ACM, 2002. https://doi.org/10.1007/3-540-45828-X_5. ieee: C. Kirsch, M. Sanvido, T. A. Henzinger, and W. Pree, “A Giotto-based helicopter control system,” in Proceedings of the 2nd International Conference on Embedded Software, Grenoble, France, 2002, vol. 2491, pp. 46–60. ista: 'Kirsch C, Sanvido M, Henzinger TA, Pree W. 2002. A Giotto-based helicopter control system. Proceedings of the 2nd International Conference on Embedded Software. EMSOFT: Embedded Software , LNCS, vol. 2491, 46–60.' mla: Kirsch, Christoph, et al. “A Giotto-Based Helicopter Control System.” Proceedings of the 2nd International Conference on Embedded Software, vol. 2491, ACM, 2002, pp. 46–60, doi:10.1007/3-540-45828-X_5. short: C. Kirsch, M. Sanvido, T.A. Henzinger, W. Pree, in:, Proceedings of the 2nd International Conference on Embedded Software, ACM, 2002, pp. 46–60. conference: end_date: 2002-10-09 location: Grenoble, France name: 'EMSOFT: Embedded Software ' start_date: 2002-10-07 date_created: 2018-12-11T12:08:46Z date_published: 2002-09-25T00:00:00Z date_updated: 2023-06-05T13:07:20Z day: '25' doi: 10.1007/3-540-45828-X_5 extern: '1' intvolume: ' 2491' language: - iso: eng month: '09' oa_version: None page: 46 - 60 publication: Proceedings of the 2nd International Conference on Embedded Software publication_identifier: isbn: - '9783540443070' publication_status: published publisher: ACM publist_id: '310' quality_controlled: '1' scopus_import: '1' status: public title: A Giotto-based helicopter control system type: conference user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 2491 year: '2002' ... --- _id: '4422' abstract: - lang: eng text: "Behavioral properties of open systems can be formalized as objectives in two-player games. Turn-based games model asynchronous interaction between the players (the system and its environment) by interleaving their moves. Concurrent games model synchronous interaction: the players always move simultaneously. Infinitary winning criteria are considered: Büchi, co-Büchi, and more general parity conditions. A generalization of determinacy for parity games to concurrent parity games demands probabilistic (mixed) strategies: either player 1 has a mixed strategy to win with probability 1 (almost-sure winning), or player 2 has a mixed strategy to win with positive probability.\r\nThis work provides efficient reductions of concurrent probabilistic Büchi and co-Büchi games to turn-based games with Büchi condition and parity winning condition with three priorities, respectively. From a theoretical point of view, the latter reduction shows that one can trade the probabilistic nature of almost-sure winning for a more general parity (fairness) condition. The reductions improve understanding of concurrent games and provide an alternative simple proof of determinacy of concurrent Büchi and co-Büchi games. From a practical point of view, the reductions turn solvers of turn-based games into solvers of concurrent probabilistic games. Thus improvements in the well-studied algorithms for the former carry over immediately to the latter. In particular, a recent improvement in the complexity of solving turn-based parity games yields an improvement in time complexity of solving concurrent probabilistic co-Büchi games from cubic to quadratic." acknowledgement: This research was supported in part by the Polish KBN grant 7-T11C-027-20, the AFOSR MURI grant F49620-00-1-0327, and the NSF Theory grant CCR-9988172. alternative_title: - LNCS article_processing_charge: No author: - first_name: Marcin full_name: Jurdziński, Marcin last_name: Jurdziński - first_name: Orna full_name: Kupferman, Orna last_name: Kupferman - first_name: Thomas A full_name: Henzinger, Thomas A id: 40876CD8-F248-11E8-B48F-1D18A9856A87 last_name: Henzinger orcid: 0000−0002−2985−7724 citation: ama: 'Jurdziński M, Kupferman O, Henzinger TA. Trading probability for fairness. In: Proceedings of the 16th International Workshop on Computer Science Logic. Vol 2471. Springer; 2002:292-305. doi:10.1007/3-540-45793-3_20' apa: 'Jurdziński, M., Kupferman, O., & Henzinger, T. A. (2002). Trading probability for fairness. In Proceedings of the 16th International Workshop on Computer Science Logic (Vol. 2471, pp. 292–305). Edinburgh, Scotland: Springer. https://doi.org/10.1007/3-540-45793-3_20' chicago: Jurdziński, Marcin, Orna Kupferman, and Thomas A Henzinger. “Trading Probability for Fairness.” In Proceedings of the 16th International Workshop on Computer Science Logic, 2471:292–305. Springer, 2002. https://doi.org/10.1007/3-540-45793-3_20. ieee: M. Jurdziński, O. Kupferman, and T. A. Henzinger, “Trading probability for fairness,” in Proceedings of the 16th International Workshop on Computer Science Logic, Edinburgh, Scotland, 2002, vol. 2471, pp. 292–305. ista: 'Jurdziński M, Kupferman O, Henzinger TA. 2002. Trading probability for fairness. Proceedings of the 16th International Workshop on Computer Science Logic. CSL: Computer Science Logic, LNCS, vol. 2471, 292–305.' mla: Jurdziński, Marcin, et al. “Trading Probability for Fairness.” Proceedings of the 16th International Workshop on Computer Science Logic, vol. 2471, Springer, 2002, pp. 292–305, doi:10.1007/3-540-45793-3_20. short: M. Jurdziński, O. Kupferman, T.A. Henzinger, in:, Proceedings of the 16th International Workshop on Computer Science Logic, Springer, 2002, pp. 292–305. conference: location: Edinburgh, Scotland name: 'CSL: Computer Science Logic' date_created: 2018-12-11T12:08:46Z date_published: 2002-09-09T00:00:00Z date_updated: 2023-06-05T10:02:54Z day: '09' doi: 10.1007/3-540-45793-3_20 extern: '1' intvolume: ' 2471' language: - iso: eng month: '09' oa_version: None page: 292 - 305 publication: Proceedings of the 16th International Workshop on Computer Science Logic publication_identifier: isbn: - '9783540442400' publication_status: published publisher: Springer publist_id: '308' quality_controlled: '1' scopus_import: '1' status: public title: Trading probability for fairness type: conference user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 2471 year: '2002' ... --- _id: '4413' abstract: - lang: eng text: 'An essential problem in component-based design is how to compose components designed in isolation. Several approaches have been proposed for specifying component interfaces that capture behavioral aspects such as interaction protocols, and for verifying interface compatibility. Likewise, several approaches have been developed for synthesizing converters between incompatible protocols. In this paper, we introduce the notion of adaptability as the property that two interfaces have when they can be made compatible by communicating through a converter that meets specified requirements. We show that verifying adaptability and synthesizing an appropriate converter are two faces of the same coin: adaptability can be formalized and solved using a game-theoretic framework, and then the converter can be synthesized as a strategy that always wins the game. Finally we show that this framework can be related to the rectification problem in trace theory.' acknowledgement: "The authors would like to thank Jerry Burch of the Cadence Berkeley Labs for many insightful discussions and suggestions.\r\n" article_processing_charge: No author: - first_name: Roberto full_name: Passerone, Roberto last_name: Passerone - first_name: Luca full_name: De Alfaro, Luca last_name: De Alfaro - first_name: Thomas A full_name: Henzinger, Thomas A id: 40876CD8-F248-11E8-B48F-1D18A9856A87 last_name: Henzinger orcid: 0000−0002−2985−7724 - first_name: Alberto full_name: Sangiovanni Vincentelli, Alberto last_name: Sangiovanni Vincentelli citation: ama: 'Passerone R, De Alfaro L, Henzinger TA, Sangiovanni Vincentelli A. Convertibility verification and converter synthesis: Two faces of the same coin. In: Proceedings of the 11th IEEE/ACM International Conference on Computer-Aided Design. IEEE; 2002:132-139. doi:10.1145/774572.774592' apa: 'Passerone, R., De Alfaro, L., Henzinger, T. A., & Sangiovanni Vincentelli, A. (2002). Convertibility verification and converter synthesis: Two faces of the same coin. In Proceedings of the 11th IEEE/ACM international conference on Computer-aided design (pp. 132–139). San Jose, CA, USA: IEEE. https://doi.org/10.1145/774572.774592' chicago: 'Passerone, Roberto, Luca De Alfaro, Thomas A Henzinger, and Alberto Sangiovanni Vincentelli. “Convertibility Verification and Converter Synthesis: Two Faces of the Same Coin.” In Proceedings of the 11th IEEE/ACM International Conference on Computer-Aided Design, 132–39. IEEE, 2002. https://doi.org/10.1145/774572.774592.' ieee: 'R. Passerone, L. De Alfaro, T. A. Henzinger, and A. Sangiovanni Vincentelli, “Convertibility verification and converter synthesis: Two faces of the same coin,” in Proceedings of the 11th IEEE/ACM international conference on Computer-aided design, San Jose, CA, USA, 2002, pp. 132–139.' ista: 'Passerone R, De Alfaro L, Henzinger TA, Sangiovanni Vincentelli A. 2002. Convertibility verification and converter synthesis: Two faces of the same coin. Proceedings of the 11th IEEE/ACM international conference on Computer-aided design. ICCAD: Computer-Aided Design, 132–139.' mla: 'Passerone, Roberto, et al. “Convertibility Verification and Converter Synthesis: Two Faces of the Same Coin.” Proceedings of the 11th IEEE/ACM International Conference on Computer-Aided Design, IEEE, 2002, pp. 132–39, doi:10.1145/774572.774592.' short: R. Passerone, L. De Alfaro, T.A. Henzinger, A. Sangiovanni Vincentelli, in:, Proceedings of the 11th IEEE/ACM International Conference on Computer-Aided Design, IEEE, 2002, pp. 132–139. conference: end_date: 2002-11-14 location: San Jose, CA, USA name: 'ICCAD: Computer-Aided Design' start_date: 2002-11-10 date_created: 2018-12-11T12:08:44Z date_published: 2002-11-01T00:00:00Z date_updated: 2023-06-05T14:21:46Z day: '01' doi: 10.1145/774572.774592 extern: '1' language: - iso: eng month: '11' oa_version: None page: 132 - 139 publication: Proceedings of the 11th IEEE/ACM international conference on Computer-aided design publication_identifier: isbn: - '9780780376076' publication_status: published publisher: IEEE publist_id: '318' quality_controlled: '1' scopus_import: '1' status: public title: 'Convertibility verification and converter synthesis: Two faces of the same coin' type: conference user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 year: '2002' ... --- _id: '4262' abstract: - lang: eng text: Natural populations are structured spatially into local populations and genetically into diverse ‘genetic backgrounds’ defined by different combinations of selected alleles. If selection maintains genetic backgrounds at constant frequency then neutral diversity is enhanced. By contrast, if background frequencies fluctuate then diversity is reduced. Provided that the population size of each background is large enough, these effects can be described by the structured coalescent process. Almost all the extant results based on the coalescent deal with a single selected locus. Yet we know that very large numbers of genes are under selection and that any substantial effects are likely to be due to the cumulative effects of many loci. Here, we set up a general framework for the extension of the coalescent to multilocus scenarios and we use it to study the simplest model, where strong balancing selection acting on a set of n loci maintains 2n backgrounds at constant frequencies and at linkage equilibrium. Analytical results show that the expected linked neutral diversity increases exponentially with the number of selected loci and can become extremely large. However, simulation results reveal that the structured coalescent approach breaks down when the number of backgrounds approaches the population size, because of stochastic fluctuations in background frequencies. A new method is needed to extend the structured coalescent to cases with large numbers of backgrounds. acknowledgement: "We thank B. Charlesworth, D. Charlesworth and F. Depaulis for valuable discussion and criticism. We are also\r\ngrateful to an anonymous reviewer, who pointed out an imprecision in the original manuscript. This work was\r\nsupported by the BBSRC." article_processing_charge: No article_type: original author: - first_name: Nicholas H full_name: Barton, Nicholas H id: 4880FE40-F248-11E8-B48F-1D18A9856A87 last_name: Barton orcid: 0000-0002-8548-5240 - first_name: Arcadio full_name: Navarro, Arcadio last_name: Navarro citation: ama: 'Barton NH, Navarro A. Extending the coalescent to multilocus systems: the case of balancing selection. Genetical Research. 2002;79(2):129-139. doi:10.1017/S0016672301005493' apa: 'Barton, N. H., & Navarro, A. (2002). Extending the coalescent to multilocus systems: the case of balancing selection. Genetical Research. Cambridge University Press. https://doi.org/10.1017/S0016672301005493' chicago: 'Barton, Nicholas H, and Arcadio Navarro. “Extending the Coalescent to Multilocus Systems: The Case of Balancing Selection.” Genetical Research. Cambridge University Press, 2002. https://doi.org/10.1017/S0016672301005493.' ieee: 'N. H. Barton and A. Navarro, “Extending the coalescent to multilocus systems: the case of balancing selection,” Genetical Research, vol. 79, no. 2. Cambridge University Press, pp. 129–139, 2002.' ista: 'Barton NH, Navarro A. 2002. Extending the coalescent to multilocus systems: the case of balancing selection. Genetical Research. 79(2), 129–139.' mla: 'Barton, Nicholas H., and Arcadio Navarro. “Extending the Coalescent to Multilocus Systems: The Case of Balancing Selection.” Genetical Research, vol. 79, no. 2, Cambridge University Press, 2002, pp. 129–39, doi:10.1017/S0016672301005493.' short: N.H. Barton, A. Navarro, Genetical Research 79 (2002) 129–139. date_created: 2018-12-11T12:07:55Z date_published: 2002-05-23T00:00:00Z date_updated: 2023-06-06T11:23:19Z day: '23' doi: 10.1017/S0016672301005493 extern: '1' external_id: pmid: - '12073551' intvolume: ' 79' issue: '2' language: - iso: eng month: '05' oa_version: None page: 129 - 139 pmid: 1 publication: Genetical Research publication_identifier: issn: - 0016-6723 publication_status: published publisher: Cambridge University Press publist_id: '1832' quality_controlled: '1' scopus_import: '1' status: public title: 'Extending the coalescent to multilocus systems: the case of balancing selection' type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 79 year: '2002' ... --- _id: '4260' abstract: - lang: eng text: 'We calculate the fixation probability of a beneficial allele that arises as the result of a unique mutation in an asexual population that is subject to recurrent deleterious mutation at rate U. Our analysis is an extension of previous works, which make a biologically restrictive assumption that selection against deleterious alleles is stronger than that on the beneficial allele of interest. We show that when selection against deleterious alleles is weak, beneficial alleles that confer a selective advantage that is small relative to U have greatly reduced probabilities of fixation. We discuss the consequences of this effect for the distribution of effects of alleles fixed during adaptation. We show that a selective sweep will increase the fixation probabilities of other beneficial mutations arising during some short interval afterward. We use the calculated fixation probabilities to estimate the expected rate of fitness improvement in an asexual population when beneficial alleles arise continually at some low rate proportional to U. We estimate the rate of mutation that is optimal in the sense that it maximizes this rate of fitness improvement. Again, this analysis relaxes the assumption made previously that selection against deleterious alleles is stronger than on beneficial alleles. ' acknowledgement: "We thank Brian Charlesworth, Arcadi Navarro, Allen Orr, Sally Otto, Mario Pineda-Krch, Rosie Redfield, Olivier Tenaillon, and two anonymous reviewers for discussions and/or helpful comments on the\r\nmanuscript. T.J. is supported by Wellcome Trust International Prize Travelling Research Fellowship no. 061530. N.B. is supported by the Biotechnology and Biological Sciences Research Council and by the Natural Environment Research Council." article_processing_charge: No article_type: original author: - first_name: Toby full_name: Johnson, Toby last_name: Johnson - first_name: Nicholas H full_name: Barton, Nicholas H id: 4880FE40-F248-11E8-B48F-1D18A9856A87 last_name: Barton orcid: 0000-0002-8548-5240 citation: ama: Johnson T, Barton NH. The effect of deleterious alleles on adaptation in asexual populations. Genetics. 2002;162(1):395-411. doi:10.1093/genetics/162.1.395 apa: Johnson, T., & Barton, N. H. (2002). The effect of deleterious alleles on adaptation in asexual populations. Genetics. Genetics Society of America. https://doi.org/10.1093/genetics/162.1.395 chicago: Johnson, Toby, and Nicholas H Barton. “The Effect of Deleterious Alleles on Adaptation in Asexual Populations.” Genetics. Genetics Society of America, 2002. https://doi.org/10.1093/genetics/162.1.395. ieee: T. Johnson and N. H. Barton, “The effect of deleterious alleles on adaptation in asexual populations,” Genetics, vol. 162, no. 1. Genetics Society of America, pp. 395–411, 2002. ista: Johnson T, Barton NH. 2002. The effect of deleterious alleles on adaptation in asexual populations. Genetics. 162(1), 395–411. mla: Johnson, Toby, and Nicholas H. Barton. “The Effect of Deleterious Alleles on Adaptation in Asexual Populations.” Genetics, vol. 162, no. 1, Genetics Society of America, 2002, pp. 395–411, doi:10.1093/genetics/162.1.395. short: T. Johnson, N.H. Barton, Genetics 162 (2002) 395–411. date_created: 2018-12-11T12:07:54Z date_published: 2002-09-01T00:00:00Z date_updated: 2023-06-06T11:45:48Z day: '01' doi: 10.1093/genetics/162.1.395 extern: '1' external_id: pmid: - '12242249' intvolume: ' 162' issue: '1' language: - iso: eng main_file_link: - open_access: '1' url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1462245/ month: '09' oa: 1 oa_version: None page: 395 - 411 pmid: 1 publication: Genetics publication_identifier: issn: - 0016-6731 publication_status: published publisher: Genetics Society of America publist_id: '1833' quality_controlled: '1' scopus_import: '1' status: public title: The effect of deleterious alleles on adaptation in asexual populations type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 162 year: '2002' ... --- _id: '4349' abstract: - lang: eng text: 'Bayesian inference is becoming a common statistical approach to phylogenetic estimation because, among other reasons, it allows for rapid analysis of large data sets with complex evolutionary models. Conveniently, Bayesian phylogenetic methods use currently available stochastic models of sequence evolution. However, as with other model-based approaches, the results of Bayesian inference are conditional on the assumed model of evolution: inadequate models (models that poorly fit the data) may result in erroneous inferences. In this article, I present a Bayesian phylogenetic method that evaluates the adequacy of evolutionary models using posterior predictive distributions. By evaluating a model''s posterior predictive performance, an adequate model can be selected for a Bayesian phylogenetic study. Although I present a single test statistic that assesses the overall (global) performance of a phylogenetic model, a variety of test statistics can be tailored to evaluate specific features (local performance) of evolutionary models to identify sources failure. The method presented here, unlike the likelihood-ratio test and parametric bootstrap, accounts for uncertainty in the phylogeny and model parameters.' acknowledgement: "This work was supported by grants from the NSF to John Huelsenbeck (MCB-0075404 and DEB0075406), to whom I am grateful for his support throughout this project. Also, I would like to express my deep thanks to Andrea Betancourt, John Huelsenbeck, Kelly Dyer, Rasmus Nielsen, and Frederick Ronquist for taking the time to read early versions of the\r\nmanuscript. Each and every one of them provided invaluable comments, that ultimately made the manuscript better. John Huelsenbeck, Bret Larget, Rasmus Nielsen, Ken Karol, and Andrea Betancourt patiently listened to me drone on about this project, and offered insightful comments that benefited this work, and for this they have my deepest gratitude. And finally, I would like to thank two anonymous reviewers who gave critical attention to the manuscript and provided valuable comments." article_processing_charge: No article_type: original author: - first_name: Jonathan P full_name: Bollback, Jonathan P id: 2C6FA9CC-F248-11E8-B48F-1D18A9856A87 last_name: Bollback orcid: 0000-0002-4624-4612 citation: ama: Bollback JP. Bayesian model adequacy and choice in phylogenetics. Molecular Biology and Evolution. 2002;19(7):1171-1180. doi:10.1093/oxfordjournals.molbev.a004175 apa: Bollback, J. P. (2002). Bayesian model adequacy and choice in phylogenetics. Molecular Biology and Evolution. Oxford University Press. https://doi.org/10.1093/oxfordjournals.molbev.a004175 chicago: Bollback, Jonathan P. “Bayesian Model Adequacy and Choice in Phylogenetics.” Molecular Biology and Evolution. Oxford University Press, 2002. https://doi.org/10.1093/oxfordjournals.molbev.a004175. ieee: J. P. Bollback, “Bayesian model adequacy and choice in phylogenetics,” Molecular Biology and Evolution, vol. 19, no. 7. Oxford University Press, pp. 1171–80, 2002. ista: Bollback JP. 2002. Bayesian model adequacy and choice in phylogenetics. Molecular Biology and Evolution. 19(7), 1171–80. mla: Bollback, Jonathan P. “Bayesian Model Adequacy and Choice in Phylogenetics.” Molecular Biology and Evolution, vol. 19, no. 7, Oxford University Press, 2002, pp. 1171–80, doi:10.1093/oxfordjournals.molbev.a004175. short: J.P. Bollback, Molecular Biology and Evolution 19 (2002) 1171–80. date_created: 2018-12-11T12:08:24Z date_published: 2002-03-25T00:00:00Z date_updated: 2023-06-06T09:18:18Z day: '25' doi: 10.1093/oxfordjournals.molbev.a004175 extern: '1' external_id: pmid: - '12082136 ' intvolume: ' 19' issue: '7' language: - iso: eng month: '03' oa_version: None page: 1171 - 80 pmid: 1 publication: Molecular Biology and Evolution publication_identifier: issn: - 0737-4038 publication_status: published publisher: Oxford University Press publist_id: '1112' quality_controlled: '1' scopus_import: '1' status: public title: Bayesian model adequacy and choice in phylogenetics type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 19 year: '2002' ... --- _id: '4263' abstract: - lang: eng text: 'We introduce a general recursion for the probability of identity in state of two individuals sampled from a population subject to mutation, migration, and random drift in a two-dimensional continuum. The recursion allows for the interactions induced by density-dependent regulation of the population, which are inevitable in a continuous population. We give explicit series expansions for large neighbourhood size and for low mutation rates respectively and investigate the accuracy of the classical Malécot formula for these general models. When neighbourhood size is small, this formula does not give the identity even over large scales. However, for large neighbourhood size, it is an accurate approximation which summarises the local population structure in terms of three quantities: the effective dispersal rate, σe; the effective population density, ρe; and a local scale, κ, at which local interactions become significant. The results are illustrated by simulations.' acknowledgement: This work was supported by grants from the EPSRC (GR/L10048 and an advanced fellowship for A.M.E.) and NERC (GR3/11635) and by the Darwin Trust of Edinburgh. We thank Anja Sturm for her assistance with the project and anonymous reviewers for helpful comments. This paper is dedicated to Charlotte, A.M.E.’s daughter born during the gestation of the manuscript. article_processing_charge: No article_type: original author: - first_name: Nicholas H full_name: Barton, Nicholas H id: 4880FE40-F248-11E8-B48F-1D18A9856A87 last_name: Barton orcid: 0000-0002-8548-5240 - first_name: Frantz full_name: Depaulis, Frantz last_name: Depaulis - first_name: Alison full_name: Etheridge, Alison last_name: Etheridge citation: ama: Barton NH, Depaulis F, Etheridge A. Neutral evolution in spatially continuous populations. Theoretical Population Biology. 2002;61(1):31-48. doi:10.1006/tpbi.2001.1557 apa: Barton, N. H., Depaulis, F., & Etheridge, A. (2002). Neutral evolution in spatially continuous populations. Theoretical Population Biology. Academic Press. https://doi.org/10.1006/tpbi.2001.1557 chicago: Barton, Nicholas H, Frantz Depaulis, and Alison Etheridge. “Neutral Evolution in Spatially Continuous Populations.” Theoretical Population Biology. Academic Press, 2002. https://doi.org/10.1006/tpbi.2001.1557. ieee: N. H. Barton, F. Depaulis, and A. Etheridge, “Neutral evolution in spatially continuous populations,” Theoretical Population Biology, vol. 61, no. 1. Academic Press, pp. 31–48, 2002. ista: Barton NH, Depaulis F, Etheridge A. 2002. Neutral evolution in spatially continuous populations. Theoretical Population Biology. 61(1), 31–48. mla: Barton, Nicholas H., et al. “Neutral Evolution in Spatially Continuous Populations.” Theoretical Population Biology, vol. 61, no. 1, Academic Press, 2002, pp. 31–48, doi:10.1006/tpbi.2001.1557. short: N.H. Barton, F. Depaulis, A. Etheridge, Theoretical Population Biology 61 (2002) 31–48. date_created: 2018-12-11T12:07:55Z date_published: 2002-02-01T00:00:00Z date_updated: 2023-06-06T09:57:49Z day: '01' doi: 10.1006/tpbi.2001.1557 extern: '1' external_id: pmid: - '11895381' intvolume: ' 61' issue: '1' language: - iso: eng month: '02' oa_version: None page: 31 - 48 pmid: 1 publication: Theoretical Population Biology publication_identifier: issn: - 0040-5809 publication_status: published publisher: Academic Press publist_id: '1830' quality_controlled: '1' scopus_import: '1' status: public title: Neutral evolution in spatially continuous populations type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 61 year: '2002' ... --- _id: '4261' abstract: - lang: eng text: Until recently, it was impracticable to identify the genes that are responsible for variation in continuous traits, or to directly observe the effects of their different alleles. Now, the abundance of genetic markers has made it possible to identify quantitative trait loci (QTL) — the regions of a chromosome or, ideally, individual sequence variants that are responsible for trait variation. What kind of QTL do we expect to find and what can our observations of QTL tell us about how organisms evolve? The key to understanding the evolutionary significance of QTL is to understand the nature of inherited variation, not in the immediate mechanistic sense of how genes influence phenotype, but, rather, to know what evolutionary forces maintain genetic variability. article_processing_charge: No article_type: original author: - first_name: Nicholas H full_name: Barton, Nicholas H id: 4880FE40-F248-11E8-B48F-1D18A9856A87 last_name: Barton orcid: 0000-0002-8548-5240 - first_name: Peter full_name: Keightley, Peter last_name: Keightley citation: ama: Barton NH, Keightley P. Understanding quantitative genetic variation. Nature Reviews Genetics. 2002;3:11-21. doi:10.1038/nrg700 apa: Barton, N. H., & Keightley, P. (2002). Understanding quantitative genetic variation. Nature Reviews Genetics. Nature Publishing Group. https://doi.org/10.1038/nrg700 chicago: Barton, Nicholas H, and Peter Keightley. “Understanding Quantitative Genetic Variation.” Nature Reviews Genetics. Nature Publishing Group, 2002. https://doi.org/10.1038/nrg700. ieee: N. H. Barton and P. Keightley, “Understanding quantitative genetic variation,” Nature Reviews Genetics, vol. 3. Nature Publishing Group, pp. 11–21, 2002. ista: Barton NH, Keightley P. 2002. Understanding quantitative genetic variation. Nature Reviews Genetics. 3, 11–21. mla: Barton, Nicholas H., and Peter Keightley. “Understanding Quantitative Genetic Variation.” Nature Reviews Genetics, vol. 3, Nature Publishing Group, 2002, pp. 11–21, doi:10.1038/nrg700. short: N.H. Barton, P. Keightley, Nature Reviews Genetics 3 (2002) 11–21. date_created: 2018-12-11T12:07:55Z date_published: 2002-01-01T00:00:00Z date_updated: 2023-06-06T10:07:00Z day: '01' doi: 10.1038/nrg700 extern: '1' external_id: pmid: - '11823787' intvolume: ' 3' language: - iso: eng month: '01' oa_version: None page: 11 - 21 pmid: 1 publication: Nature Reviews Genetics publication_identifier: issn: - 1471-0056 publication_status: published publisher: Nature Publishing Group publist_id: '1831' quality_controlled: '1' scopus_import: '1' status: public title: Understanding quantitative genetic variation type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 3 year: '2002' ... --- _id: '4347' abstract: - lang: eng text: 'Phylogenetic trees can be rooted by a number of criteria. Here, we introduce a Bayesian method for inferring the root of a phylogenetic tree by using one of several criteria: the outgroup, molecular clock, and nonreversible model of DNA substitution. We perform simulation analyses to examine the relative ability of these three criteria to correctly identify the root of the tree. The outgroup and molecular clock criteria were best able to identify the root of the tree, whereas the nonreversible model was able to identify the root only when the substitution process was highly nonreversible. We also examined the performance of the criteria for a tree of four species for which the topology and root position are well supported. Results of the analyses of these data are consistent with the simulation results.' article_processing_charge: No article_type: original author: - first_name: John full_name: Huelsenbeck, John last_name: Huelsenbeck - first_name: Jonathan P full_name: Bollback, Jonathan P id: 2C6FA9CC-F248-11E8-B48F-1D18A9856A87 last_name: Bollback orcid: 0000-0002-4624-4612 - first_name: Amy full_name: Levine, Amy last_name: Levine citation: ama: Huelsenbeck J, Bollback JP, Levine A. Inferring the root of a phylogenetic tree. Systematic Biology. 2002;51(1):32-43. doi:10.1080/106351502753475862 apa: Huelsenbeck, J., Bollback, J. P., & Levine, A. (2002). Inferring the root of a phylogenetic tree. Systematic Biology. Oxford University Press. https://doi.org/10.1080/106351502753475862 chicago: Huelsenbeck, John, Jonathan P Bollback, and Amy Levine. “Inferring the Root of a Phylogenetic Tree.” Systematic Biology. Oxford University Press, 2002. https://doi.org/10.1080/106351502753475862. ieee: J. Huelsenbeck, J. P. Bollback, and A. Levine, “Inferring the root of a phylogenetic tree,” Systematic Biology, vol. 51, no. 1. Oxford University Press, pp. 32–43, 2002. ista: Huelsenbeck J, Bollback JP, Levine A. 2002. Inferring the root of a phylogenetic tree. Systematic Biology. 51(1), 32–43. mla: Huelsenbeck, John, et al. “Inferring the Root of a Phylogenetic Tree.” Systematic Biology, vol. 51, no. 1, Oxford University Press, 2002, pp. 32–43, doi:10.1080/106351502753475862. short: J. Huelsenbeck, J.P. Bollback, A. Levine, Systematic Biology 51 (2002) 32–43. date_created: 2018-12-11T12:08:23Z date_published: 2002-02-01T00:00:00Z date_updated: 2023-06-06T09:53:27Z day: '01' doi: 10.1080/106351502753475862 extern: '1' external_id: pmid: - '11943091' intvolume: ' 51' issue: '1' language: - iso: eng month: '02' oa_version: None page: 32 - 43 pmid: 1 publication: Systematic Biology publication_identifier: issn: - 0039-7989 publication_status: published publisher: Oxford University Press publist_id: '1113' quality_controlled: '1' scopus_import: '1' status: public title: Inferring the root of a phylogenetic tree type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 51 year: '2002' ... --- _id: '4407' abstract: - lang: eng text: 'This paper presents a complete axiomatization of two decidable propositional real-time linear temporal logics: Event Clock Logic (EventClockTL) and Metric Interval Temporal Logic with past (MetricIntervalTL). The completeness proof consists of an effective proof building procedure for EventClockTL. From this result we obtain a complete axiomatization of MetricIntervalTL by providing axioms translating MetricIntervalTL formulae into EventClockTL formulae, the two logics being equally expressive. Our proof is structured to yield axiomatizations also for interesting fragments of these logics, such as the linear temporal logic of the real numbers (TLR).' article_processing_charge: No article_type: original author: - first_name: Jean full_name: Raskin, Jean last_name: Raskin - first_name: Pierre full_name: Schobbens, Pierre last_name: Schobbens - first_name: Thomas A full_name: Henzinger, Thomas A id: 40876CD8-F248-11E8-B48F-1D18A9856A87 last_name: Henzinger orcid: 0000−0002−2985−7724 citation: ama: Raskin J, Schobbens P, Henzinger TA. Axioms for real-time logics. Theoretical Computer Science. 2002;274(1-2):151-182. doi:10.1016/S0304-3975(00)00308-X apa: Raskin, J., Schobbens, P., & Henzinger, T. A. (2002). Axioms for real-time logics. Theoretical Computer Science. Elsevier. https://doi.org/10.1016/S0304-3975(00)00308-X chicago: Raskin, Jean, Pierre Schobbens, and Thomas A Henzinger. “Axioms for Real-Time Logics.” Theoretical Computer Science. Elsevier, 2002. https://doi.org/10.1016/S0304-3975(00)00308-X. ieee: J. Raskin, P. Schobbens, and T. A. Henzinger, “Axioms for real-time logics,” Theoretical Computer Science, vol. 274, no. 1–2. Elsevier, pp. 151–182, 2002. ista: Raskin J, Schobbens P, Henzinger TA. 2002. Axioms for real-time logics. Theoretical Computer Science. 274(1–2), 151–182. mla: Raskin, Jean, et al. “Axioms for Real-Time Logics.” Theoretical Computer Science, vol. 274, no. 1–2, Elsevier, 2002, pp. 151–82, doi:10.1016/S0304-3975(00)00308-X. short: J. Raskin, P. Schobbens, T.A. Henzinger, Theoretical Computer Science 274 (2002) 151–182. date_created: 2018-12-11T12:08:42Z date_published: 2002-03-01T00:00:00Z date_updated: 2023-06-06T09:10:56Z day: '01' doi: 10.1016/S0304-3975(00)00308-X extern: '1' intvolume: ' 274' issue: 1-2 language: - iso: eng month: '03' oa_version: None page: 151 - 182 publication: Theoretical Computer Science publication_identifier: issn: - 0304-3975 publication_status: published publisher: Elsevier publist_id: '324' quality_controlled: '1' scopus_import: '1' status: public title: Axioms for real-time logics type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 274 year: '2002' ... --- _id: '4258' abstract: - lang: eng text: We studied the effect of multilocus balancing selection on neutral nucleotide variability at linked sites by simulating a model where diallelic polymorphisms are maintained at an arbitrary number of selected loci by means of symmetric overdominance. Different combinations of alleles define different genetic backgrounds that subdivide the population and strongly affect variability. Several multilocus fitness regimes with different degrees of epistasis and gametic disequilibrium are allowed. Analytical results based on a multilocus extension of the structured coalescent predict that the expected linked neutral diversity increases exponentially with the number of selected loci and can become extremely large. Our simulation results show that although variability increases with the number of genetic backgrounds that are maintained in the population, it is reduced by random fluctuations in the frequencies of those backgrounds and does not reach high levels even in very large populations. We also show that previous results on balancing selection in single-locus systems do not extend to the multilocus scenario in a straightforward way. Different patterns of linkage disequilibrium and of the frequency spectrum of neutral mutations are expected under different degrees of epistasis. Interestingly, the power to detect balancing selection using deviations from a neutral distribution of allele frequencies seems to be diminished under the fitness regime that leads to the largest increase of variability over the neutral case. This and other results are discussed in the light of data from the Mhc. acknowledgement: We thank P. Andolfatto, P. Awadalla, B. Charlesworth, D. Charles- Guillaudeux, T., M. Janer, G. K. S. Wong, T. Spies and D. E. Geraghty, F. Depaulis, S. Otto, J. Rozas, and three anonymous reviewers for valuable discussion and criticism. A.N. is grateful to F. Depaulis, whose comments were particularly helpful (and extremely funny), and to D. Charlesworth, whose ideas made this work readable. This work was supported by Biotechnology and Biological Sciences Research Council/Engineering and Physical Sciences Research Council. article_processing_charge: No article_type: original author: - first_name: Arcadio full_name: Navarro, Arcadio last_name: Navarro - first_name: Nicholas H full_name: Barton, Nicholas H id: 4880FE40-F248-11E8-B48F-1D18A9856A87 last_name: Barton orcid: 0000-0002-8548-5240 citation: ama: Navarro A, Barton NH. The effects of multilocus balancing selection on neutral variability. Genetics. 2002;161(2):849-863. doi:10.1093/genetics/161.2.849 apa: Navarro, A., & Barton, N. H. (2002). The effects of multilocus balancing selection on neutral variability. Genetics. Genetics Society of America. https://doi.org/10.1093/genetics/161.2.849 chicago: Navarro, Arcadio, and Nicholas H Barton. “The Effects of Multilocus Balancing Selection on Neutral Variability.” Genetics. Genetics Society of America, 2002. https://doi.org/10.1093/genetics/161.2.849. ieee: A. Navarro and N. H. Barton, “The effects of multilocus balancing selection on neutral variability,” Genetics, vol. 161, no. 2. Genetics Society of America, pp. 849–863, 2002. ista: Navarro A, Barton NH. 2002. The effects of multilocus balancing selection on neutral variability. Genetics. 161(2), 849–863. mla: Navarro, Arcadio, and Nicholas H. Barton. “The Effects of Multilocus Balancing Selection on Neutral Variability.” Genetics, vol. 161, no. 2, Genetics Society of America, 2002, pp. 849–63, doi:10.1093/genetics/161.2.849. short: A. Navarro, N.H. Barton, Genetics 161 (2002) 849–863. date_created: 2018-12-11T12:07:53Z date_published: 2002-06-01T00:00:00Z date_updated: 2023-06-06T12:02:32Z day: '01' doi: 10.1093/genetics/161.2.849 extern: '1' external_id: pmid: - '12072479' intvolume: ' 161' issue: '2' language: - iso: eng main_file_link: - open_access: '1' url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1462137/ month: '06' oa: 1 oa_version: Published Version page: 849 - 863 pmid: 1 publication: Genetics publication_identifier: issn: - 0016-6731 publication_status: published publisher: Genetics Society of America publist_id: '1835' quality_controlled: '1' scopus_import: '1' status: public title: The effects of multilocus balancing selection on neutral variability type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 161 year: '2002' ... --- _id: '4259' abstract: - lang: eng text: 'We extend current multilocus models to describe the effects of migration, recombination, selection, and nonrandom mating on sets of genes in diploids with varied modes of inheritance, allowing us to consider the patterns of nuclear and cytonuclear associations (disequilibria) under various models of migration. We show the relationship between the multilocus notation recently presented by Kirkpatrick, Johnson, and Barton (developed from previous work by Barton and Turelli) and the cytonuclear parameterization of Asmussen, Arnold, and Avise and extend this notation to describe associations between cytoplasmic elements and multiple nuclear genes. Under models with sexual symmetry, both nuclear-nuclear and cytonuclear disequilibria are equivalent. They differ, however, in cases involving some type of sexual asymmetry, which is then reflected in the asymmetric inheritance of cytoplasmic markers. An example given is the case of different migration rates in males and females; simulations using 2, 3, 4, or 5 unlinked autosomal markers with a maternally inherited cytoplasmic marker illustrate how nuclear-nuclear and cytonuclear associations can be used to separately estimate female and male migration rates. The general framework developed here allows us to investigate conditions where associations between loci with different modes of inheritance are not equivalent and to use this nonequivalence to test for deviations from simple models of admixture. ' acknowledgement: The authors thank Toby Johnson for his helpful comments on this manuscript. This work was supported by a National Science Foundation NATO postdoctoral fellowship and National Science Foundation grants DEB-9813335 and DEB-0108242 to M.E.O.; N.H.B. gratefully acknowledges the support of the Darwin Trust of Edinburgh and the National Environmental Research Council. article_processing_charge: No article_type: original author: - first_name: Maria full_name: Orive, Maria last_name: Orive - first_name: Nicholas H full_name: Barton, Nicholas H id: 4880FE40-F248-11E8-B48F-1D18A9856A87 last_name: Barton orcid: 0000-0002-8548-5240 citation: ama: Orive M, Barton NH. Associations between cytoplasmic and nuclear loci in hybridizing populations. Genetics. 2002;162(3):1469-1485. doi:10.1093/genetics/162.3.1469 apa: Orive, M., & Barton, N. H. (2002). Associations between cytoplasmic and nuclear loci in hybridizing populations. Genetics. Genetics Society of America. https://doi.org/10.1093/genetics/162.3.1469 chicago: Orive, Maria, and Nicholas H Barton. “Associations between Cytoplasmic and Nuclear Loci in Hybridizing Populations.” Genetics. Genetics Society of America, 2002. https://doi.org/10.1093/genetics/162.3.1469. ieee: M. Orive and N. H. Barton, “Associations between cytoplasmic and nuclear loci in hybridizing populations,” Genetics, vol. 162, no. 3. Genetics Society of America, pp. 1469–1485, 2002. ista: Orive M, Barton NH. 2002. Associations between cytoplasmic and nuclear loci in hybridizing populations. Genetics. 162(3), 1469–1485. mla: Orive, Maria, and Nicholas H. Barton. “Associations between Cytoplasmic and Nuclear Loci in Hybridizing Populations.” Genetics, vol. 162, no. 3, Genetics Society of America, 2002, pp. 1469–85, doi:10.1093/genetics/162.3.1469. short: M. Orive, N.H. Barton, Genetics 162 (2002) 1469–1485. date_created: 2018-12-11T12:07:54Z date_published: 2002-11-01T00:00:00Z date_updated: 2023-06-06T12:19:54Z day: '01' doi: 10.1093/genetics/162.3.1469 extern: '1' external_id: pmid: - '12454089' intvolume: ' 162' issue: '3' language: - iso: eng main_file_link: - open_access: '1' url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1462324/ month: '11' oa: 1 oa_version: Published Version page: 1469 - 1485 pmid: 1 publication: Genetics publication_identifier: issn: - 0016-6731 publication_status: published publisher: Genetics Society of America publist_id: '1836' quality_controlled: '1' scopus_import: '1' status: public title: Associations between cytoplasmic and nuclear loci in hybridizing populations type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 162 year: '2002' ... --- _id: '4209' abstract: - lang: eng text: We have identified widerborst (wdb), a B' regulatory subunit of PP2A, as a conserved component of planar cell polarization mechanisms in both Drosophila and in zebrafish. In Drosophila, wdb acts at two steps during planar polarization of wing epithelial cells. It is required to organize tissue polarity proteins into proximal and distal cortical domains, thus determining wing hair orientation. It is also needed to generate the polarized membrane outgrowth that becomes the wing hair. Widerborst activates the catalytic subunit of PP2A and localizes to the distal side of a planar microtubule web that lies at the level of apical cell junctions. This suggests that polarized PP2A activation along the planar microtubule web is important for planar polarization. In zebrafish, two wdb homologs are required for convergent extension during gastrulation, supporting the conjecture that Drosophila planar cell polarization and vertebrate gastrulation movements are regulated by similar mechanisms. acknowledgement: We gratefully acknowledge Bianca Habermann for assistance with bioinformatics, Jens Rietdorf and Arshad Desai for help with deconvolution, and Tadashi Uemura and Rick Fehon for providing antibodies. Arshad Desai, Christian Dahmann, Tony Hyman and Elly Tanaka provided helpful comments on the manuscript. Part of this work was performed at the EMBL in Heidelberg. article_processing_charge: No article_type: original author: - first_name: Michael full_name: Hannus, Michael last_name: Hannus - first_name: Fabian full_name: Feiguin, Fabian last_name: Feiguin - first_name: Carl-Philipp J full_name: Heisenberg, Carl-Philipp J id: 39427864-F248-11E8-B48F-1D18A9856A87 last_name: Heisenberg orcid: 0000-0002-0912-4566 - first_name: Suzanne full_name: Eaton, Suzanne last_name: Eaton citation: ama: Hannus M, Feiguin F, Heisenberg C-PJ, Eaton S. Planar cell polarization requires Widerborst, a B′ regulatory subunit of protein phosphatase 2A. Development. 2002;129(14):3493-3503. doi:10.1242/dev.129.14.3493 apa: Hannus, M., Feiguin, F., Heisenberg, C.-P. J., & Eaton, S. (2002). Planar cell polarization requires Widerborst, a B′ regulatory subunit of protein phosphatase 2A. Development. Company of Biologists. https://doi.org/10.1242/dev.129.14.3493 chicago: Hannus, Michael, Fabian Feiguin, Carl-Philipp J Heisenberg, and Suzanne Eaton. “Planar Cell Polarization Requires Widerborst, a B′ Regulatory Subunit of Protein Phosphatase 2A.” Development. Company of Biologists, 2002. https://doi.org/10.1242/dev.129.14.3493. ieee: M. Hannus, F. Feiguin, C.-P. J. Heisenberg, and S. Eaton, “Planar cell polarization requires Widerborst, a B′ regulatory subunit of protein phosphatase 2A,” Development, vol. 129, no. 14. Company of Biologists, pp. 3493–3503, 2002. ista: Hannus M, Feiguin F, Heisenberg C-PJ, Eaton S. 2002. Planar cell polarization requires Widerborst, a B′ regulatory subunit of protein phosphatase 2A. Development. 129(14), 3493–3503. mla: Hannus, Michael, et al. “Planar Cell Polarization Requires Widerborst, a B′ Regulatory Subunit of Protein Phosphatase 2A.” Development, vol. 129, no. 14, Company of Biologists, 2002, pp. 3493–503, doi:10.1242/dev.129.14.3493. short: M. Hannus, F. Feiguin, C.-P.J. Heisenberg, S. Eaton, Development 129 (2002) 3493–3503. date_created: 2018-12-11T12:07:36Z date_published: 2002-07-15T00:00:00Z date_updated: 2023-06-06T14:07:49Z day: '15' doi: 10.1242/dev.129.14.3493 extern: '1' external_id: pmid: - '12091318' intvolume: ' 129' issue: '14' language: - iso: eng month: '07' oa_version: None page: 3493 - 3503 pmid: 1 publication: Development publication_identifier: issn: - 0950-1991 publication_status: published publisher: Company of Biologists publist_id: '1909' quality_controlled: '1' scopus_import: '1' status: public title: Planar cell polarization requires Widerborst, a B′ regulatory subunit of protein phosphatase 2A type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 129 year: '2002' ... --- _id: '4207' abstract: - lang: eng text: Vertebrate homologues of the Strabismus/van Gogh (stbm/vang) gene have been implicated in patterning and morphogenesis during gastrulation. Recent work shows that stbm/vang is mutated in zebrafish trilobite mutants and that stbm/vang is required for morphogenesis but not patterning during zebrafish gastrulation. article_processing_charge: No article_type: original author: - first_name: Carl-Philipp J full_name: Heisenberg, Carl-Philipp J id: 39427864-F248-11E8-B48F-1D18A9856A87 last_name: Heisenberg orcid: 0000-0002-0912-4566 citation: ama: 'Heisenberg C-PJ. Wnt signalling: Refocusing on Strabismus. Current Biology. 2002;12(19):R657-R659. doi:10.1016/S0960-9822(02)01160-0' apa: 'Heisenberg, C.-P. J. (2002). Wnt signalling: Refocusing on Strabismus. Current Biology. Cell Press. https://doi.org/10.1016/S0960-9822(02)01160-0' chicago: 'Heisenberg, Carl-Philipp J. “Wnt Signalling: Refocusing on Strabismus.” Current Biology. Cell Press, 2002. https://doi.org/10.1016/S0960-9822(02)01160-0.' ieee: 'C.-P. J. Heisenberg, “Wnt signalling: Refocusing on Strabismus,” Current Biology, vol. 12, no. 19. Cell Press, pp. R657–R659, 2002.' ista: 'Heisenberg C-PJ. 2002. Wnt signalling: Refocusing on Strabismus. Current Biology. 12(19), R657–R659.' mla: 'Heisenberg, Carl-Philipp J. “Wnt Signalling: Refocusing on Strabismus.” Current Biology, vol. 12, no. 19, Cell Press, 2002, pp. R657–59, doi:10.1016/S0960-9822(02)01160-0.' short: C.-P.J. Heisenberg, Current Biology 12 (2002) R657–R659. date_created: 2018-12-11T12:07:35Z date_published: 2002-10-01T00:00:00Z date_updated: 2023-06-06T15:09:53Z day: '01' doi: 10.1016/S0960-9822(02)01160-0 extern: '1' external_id: pmid: - '12361585' intvolume: ' 12' issue: '19' language: - iso: eng month: '10' oa_version: None page: R657 - R659 pmid: 1 publication: Current Biology publication_identifier: issn: - 0960-9822 publication_status: published publisher: Cell Press publist_id: '1912' quality_controlled: '1' scopus_import: '1' status: public title: 'Wnt signalling: Refocusing on Strabismus' type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 12 year: '2002' ... --- _id: '4194' abstract: - lang: eng text: Cells at the anterior boundary of the neural plate (ANB) can induce telencephalic gene expression when transplanted to more posterior regions. Here, we identify a secreted Frizzled-related Wnt antagonist, Tic, that is expressed in ANB cells and can cell nonautonomously promote telencephalic gene expression in a concentration-dependent manner. Moreover, abrogation of Tlc function compromises telencephalic development. We also identify Wnt8b as a locally acting modulator of regional fate in the anterior neural plate and a likely target for antagonism by Tic. Finally, we show that tlc expression is regulated by signals that establish early antero-posterior and dorso-ventral ectodermal pattern. From these studies, we propose that local antagonism of Wnt activity within the anterior ectoderm is required to establish the telencephalon. acknowledgement: We thank many of our colleagues, especially Randy Moon, for providing reagents used in this study. This study was supported by the Wellcome Trust, MRC, and BBSRC to S.W.W. and C.H. S.W.W. is a Wellcome Trust Senior Research Fellow. article_processing_charge: No article_type: original author: - first_name: Corinne full_name: Houart, Corinne last_name: Houart - first_name: Luca full_name: Caneparo, Luca last_name: Caneparo - first_name: Carl-Philipp J full_name: Heisenberg, Carl-Philipp J id: 39427864-F248-11E8-B48F-1D18A9856A87 last_name: Heisenberg orcid: 0000-0002-0912-4566 - first_name: K Anukampa full_name: Barth, K Anukampa last_name: Barth - first_name: Masaya full_name: Take Uchi, Masaya last_name: Take Uchi - first_name: Stephen full_name: Wilson, Stephen last_name: Wilson citation: ama: Houart C, Caneparo L, Heisenberg C-PJ, Barth KA, Take Uchi M, Wilson S. Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling. Neuron. 2002;35(2):255-265. doi:10.1016/S0896-6273(02)00751-1 apa: Houart, C., Caneparo, L., Heisenberg, C.-P. J., Barth, K. A., Take Uchi, M., & Wilson, S. (2002). Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling. Neuron. Elsevier. https://doi.org/10.1016/S0896-6273(02)00751-1 chicago: Houart, Corinne, Luca Caneparo, Carl-Philipp J Heisenberg, K Anukampa Barth, Masaya Take Uchi, and Stephen Wilson. “Establishment of the Telencephalon during Gastrulation by Local Antagonism of Wnt Signaling.” Neuron. Elsevier, 2002. https://doi.org/10.1016/S0896-6273(02)00751-1. ieee: C. Houart, L. Caneparo, C.-P. J. Heisenberg, K. A. Barth, M. Take Uchi, and S. Wilson, “Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling,” Neuron, vol. 35, no. 2. Elsevier, pp. 255–265, 2002. ista: Houart C, Caneparo L, Heisenberg C-PJ, Barth KA, Take Uchi M, Wilson S. 2002. Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling. Neuron. 35(2), 255–265. mla: Houart, Corinne, et al. “Establishment of the Telencephalon during Gastrulation by Local Antagonism of Wnt Signaling.” Neuron, vol. 35, no. 2, Elsevier, 2002, pp. 255–65, doi:10.1016/S0896-6273(02)00751-1. short: C. Houart, L. Caneparo, C.-P.J. Heisenberg, K.A. Barth, M. Take Uchi, S. Wilson, Neuron 35 (2002) 255–265. date_created: 2018-12-11T12:07:30Z date_published: 2002-07-18T00:00:00Z date_updated: 2023-06-07T09:43:19Z day: '18' doi: 10.1016/S0896-6273(02)00751-1 extern: '1' external_id: pmid: - '12160744' intvolume: ' 35' issue: '2' language: - iso: eng month: '07' oa_version: None page: 255 - 265 pmid: 1 publication: Neuron publication_identifier: issn: - 0896-6273 publication_status: published publisher: Elsevier publist_id: '1925' quality_controlled: '1' scopus_import: '1' status: public title: Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 35 year: '2002' ... --- _id: '4148' abstract: - lang: eng text: Members of the Wnt family have been implicated in a variety of developmental processes including axis formation, Patterning of the central nervous system and tissue morphogenesis. Recent studies have shown that a Wnt signalling pathway similar to that involved in the establishment of planar cell polarity in Drosophila regulates convergent extension movements during zebrafish and Xenopus gastrulation. This finding provides a good starting point to dissect the complex cell biology and genetic regulation of vertebrate gastrulation movements. acknowledgement: We would like to thank Steve Wilson for encouraging us to write this article and for critical comments on this manuscript, and Lila Solnica-Krezel for communicating results prior to publication. MT is supported by an MRC Career Development Award, MLC by a Wellcome Trust Fellowship and CPH by an Emmy–Noether–Fellowship from the DFG. article_processing_charge: No article_type: original author: - first_name: Masazumi full_name: Tada, Masazumi last_name: Tada - first_name: Miguel full_name: Concha, Miguel last_name: Concha - first_name: Carl-Philipp J full_name: Heisenberg, Carl-Philipp J id: 39427864-F248-11E8-B48F-1D18A9856A87 last_name: Heisenberg orcid: 0000-0002-0912-4566 citation: ama: Tada M, Concha M, Heisenberg C-PJ. Non-canonical Wnt signalling and regulation of gastrulation movements. Seminars in Cell & Developmental Biology. 2002;13(3):251-260. doi:10.1016/S1084-9521(02)00052-6 apa: Tada, M., Concha, M., & Heisenberg, C.-P. J. (2002). Non-canonical Wnt signalling and regulation of gastrulation movements. Seminars in Cell & Developmental Biology. Academic Press. https://doi.org/10.1016/S1084-9521(02)00052-6 chicago: Tada, Masazumi, Miguel Concha, and Carl-Philipp J Heisenberg. “Non-Canonical Wnt Signalling and Regulation of Gastrulation Movements.” Seminars in Cell & Developmental Biology. Academic Press, 2002. https://doi.org/10.1016/S1084-9521(02)00052-6. ieee: M. Tada, M. Concha, and C.-P. J. Heisenberg, “Non-canonical Wnt signalling and regulation of gastrulation movements,” Seminars in Cell & Developmental Biology, vol. 13, no. 3. Academic Press, pp. 251–260, 2002. ista: Tada M, Concha M, Heisenberg C-PJ. 2002. Non-canonical Wnt signalling and regulation of gastrulation movements. Seminars in Cell & Developmental Biology. 13(3), 251–260. mla: Tada, Masazumi, et al. “Non-Canonical Wnt Signalling and Regulation of Gastrulation Movements.” Seminars in Cell & Developmental Biology, vol. 13, no. 3, Academic Press, 2002, pp. 251–60, doi:10.1016/S1084-9521(02)00052-6. short: M. Tada, M. Concha, C.-P.J. Heisenberg, Seminars in Cell & Developmental Biology 13 (2002) 251–260. date_created: 2018-12-11T12:07:13Z date_published: 2002-06-01T00:00:00Z date_updated: 2023-06-07T09:50:14Z day: '01' doi: 10.1016/S1084-9521(02)00052-6 extern: '1' external_id: pmid: - '12137734' intvolume: ' 13' issue: '3' language: - iso: eng month: '06' oa_version: None page: 251 - 260 pmid: 1 publication: Seminars in Cell & Developmental Biology publication_identifier: issn: - 1084-9521 publication_status: published publisher: Academic Press publist_id: '1973' quality_controlled: '1' scopus_import: '1' status: public title: Non-canonical Wnt signalling and regulation of gastrulation movements type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 13 year: '2002' ... --- _id: '4196' abstract: - lang: eng text: During vertebrate gastrulation, large cellular rearrangements lead to the formation of the three germ layers, ectoderm, mesoderm and endoderm. Zebrafish offer many genetic and experimental advantages for studying vertebrate gastrulation movements. For instance, several mutants, including silberblick, knypek and trilobite, exhibit defects in morphogenesis during gastrulation. The identification of the genes mutated in these lines together with the analysis of the mutant phenotypes has provided new insights into the molecular and cellular mechanisms that underlie vertebrate gastrulation movements. acknowledgement: We would like to thank Miguel Concha, Will Norton, Tim Geach, Suzanne Eaton, Kimbo Kotovic, Jenny Geiger and Steve Wilson for critical comments on this manuscript, and Lila Solnica-Krezel for providing results prior to publication. C.-P.H. is supported by an Emmy-Noether-Fellowship from the DFG and M.T. by an MRC Career Development Award. article_processing_charge: No article_type: original author: - first_name: Carl-Philipp J full_name: Heisenberg, Carl-Philipp J id: 39427864-F248-11E8-B48F-1D18A9856A87 last_name: Heisenberg orcid: 0000-0002-0912-4566 - first_name: Masazumi full_name: Tada, Masazumi last_name: Tada citation: ama: 'Heisenberg C-PJ, Tada M. Zebrafish gastrulation movements: bridging cell and developmental biology. Seminars in Cell & Developmental Biology. 2002;13(6):471-479. doi:10.1016/S1084952102001003' apa: 'Heisenberg, C.-P. J., & Tada, M. (2002). Zebrafish gastrulation movements: bridging cell and developmental biology. Seminars in Cell & Developmental Biology. Academic Press. https://doi.org/10.1016/S1084952102001003' chicago: 'Heisenberg, Carl-Philipp J, and Masazumi Tada. “Zebrafish Gastrulation Movements: Bridging Cell and Developmental Biology.” Seminars in Cell & Developmental Biology. Academic Press, 2002. https://doi.org/10.1016/S1084952102001003.' ieee: 'C.-P. J. Heisenberg and M. Tada, “Zebrafish gastrulation movements: bridging cell and developmental biology,” Seminars in Cell & Developmental Biology, vol. 13, no. 6. Academic Press, pp. 471–479, 2002.' ista: 'Heisenberg C-PJ, Tada M. 2002. Zebrafish gastrulation movements: bridging cell and developmental biology. Seminars in Cell & Developmental Biology. 13(6), 471–479.' mla: 'Heisenberg, Carl-Philipp J., and Masazumi Tada. “Zebrafish Gastrulation Movements: Bridging Cell and Developmental Biology.” Seminars in Cell & Developmental Biology, vol. 13, no. 6, Academic Press, 2002, pp. 471–79, doi:10.1016/S1084952102001003.' short: C.-P.J. Heisenberg, M. Tada, Seminars in Cell & Developmental Biology 13 (2002) 471–479. date_created: 2018-12-11T12:07:31Z date_published: 2002-12-01T00:00:00Z date_updated: 2023-06-07T09:28:48Z day: '01' doi: 10.1016/S1084952102001003 extern: '1' external_id: pmid: - '12468250' intvolume: ' 13' issue: '6' language: - iso: eng month: '12' oa_version: None page: 471 - 479 pmid: 1 publication: Seminars in Cell & Developmental Biology publication_identifier: issn: - 1084-9521 publication_status: published publisher: Academic Press publist_id: '1920' quality_controlled: '1' scopus_import: '1' status: public title: 'Zebrafish gastrulation movements: bridging cell and developmental biology' type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 13 year: '2002' ... --- _id: '4199' abstract: - lang: eng text: Recent studies on vertebrate homologues of the van gogh/strabismus (vang/stbm) gene, a key player in planar cell polarity signalling in Drosophila, show that vang/stbm is involved in patterning and morphogenesis during vertebrate gastrulation where it modulates two distinct Wnt signals. article_processing_charge: No article_type: original author: - first_name: Carl-Philipp J full_name: Heisenberg, Carl-Philipp J id: 39427864-F248-11E8-B48F-1D18A9856A87 last_name: Heisenberg orcid: 0000-0002-0912-4566 - first_name: Masazumi full_name: Tada, Masazumi last_name: Tada citation: ama: 'Heisenberg C-PJ, Tada M. Wnt signalling: A moving picture emerges from van gogh. Current Biology. 2002;12(4):R126-R128. doi:10.1016/S0960-9822(02)00704-2' apa: 'Heisenberg, C.-P. J., & Tada, M. (2002). Wnt signalling: A moving picture emerges from van gogh. Current Biology. Cell Press. https://doi.org/10.1016/S0960-9822(02)00704-2' chicago: 'Heisenberg, Carl-Philipp J, and Masazumi Tada. “Wnt Signalling: A Moving Picture Emerges from van Gogh.” Current Biology. Cell Press, 2002. https://doi.org/10.1016/S0960-9822(02)00704-2.' ieee: 'C.-P. J. Heisenberg and M. Tada, “Wnt signalling: A moving picture emerges from van gogh,” Current Biology, vol. 12, no. 4. Cell Press, pp. R126–R128, 2002.' ista: 'Heisenberg C-PJ, Tada M. 2002. Wnt signalling: A moving picture emerges from van gogh. Current Biology. 12(4), R126–R128.' mla: 'Heisenberg, Carl-Philipp J., and Masazumi Tada. “Wnt Signalling: A Moving Picture Emerges from van Gogh.” Current Biology, vol. 12, no. 4, Cell Press, 2002, pp. R126–28, doi:10.1016/S0960-9822(02)00704-2.' short: C.-P.J. Heisenberg, M. Tada, Current Biology 12 (2002) R126–R128. date_created: 2018-12-11T12:07:32Z date_published: 2002-02-19T00:00:00Z date_updated: 2023-06-07T08:54:35Z day: '19' doi: 10.1016/S0960-9822(02)00704-2 extern: '1' external_id: pmid: - '11864583' intvolume: ' 12' issue: '4' language: - iso: eng month: '02' oa_version: None page: R126 - R128 pmid: 1 publication: Current Biology publication_identifier: issn: - 0960-9822 publication_status: published publisher: Cell Press publist_id: '1919' quality_controlled: '1' scopus_import: '1' status: public title: 'Wnt signalling: A moving picture emerges from van gogh' type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 12 year: '2002' ... --- _id: '4139' abstract: - lang: eng text: Pilot studies in England by Stopka and Macdonald revealed that allogrooming in the Old World wood mouse, Apodemus sylvaticus, is a commodity that males can trade for reproductive benefits with females. This study, which used a combination of field study and observations in experimental enclosures, revealed that specific experimental conditions such as group-size and sex-ratio manipulations have a significant effect on the pattern of allogrooming exchanged between individuals. Furthermore, females from the Czech population were more likely to associate with each other as revealed by the clustering of activity centers of females (i.e., as opposed to almost exclusive ranges in English populations), and also by the higher intensity of allogrooming exchanged between females (i.e., virtually lacking in the previous experiment with English mice). Therefore, geographic variation and specific social conditions seem to be important driving factors for allogrooming behavior. Together with changes in overall grooming patterns, allogrooming between males and females remained invariably asymmetrical over all four experimental groups (i.e., two conditions for each sex) in that males provided more allogrooming to females than they received from them. article_processing_charge: No article_type: original author: - first_name: Jitka full_name: Polechova, Jitka id: 3BBFB084-F248-11E8-B48F-1D18A9856A87 last_name: Polechova orcid: 0000-0003-0951-3112 - first_name: P. full_name: Stopka, P. last_name: Stopka citation: ama: Polechova J, Stopka P. Geometry of social relationships in the Old World wood mouse, Apodemus sylvaticus. Canadian Journal of Zoology. 2002;80(8):1383-1388. doi:10.1139/z02-128 apa: Polechova, J., & Stopka, P. (2002). Geometry of social relationships in the Old World wood mouse, Apodemus sylvaticus. Canadian Journal of Zoology. NRC Research Press. https://doi.org/10.1139/z02-128 chicago: Polechova, Jitka, and P. Stopka. “Geometry of Social Relationships in the Old World Wood Mouse, Apodemus Sylvaticus.” Canadian Journal of Zoology. NRC Research Press, 2002. https://doi.org/10.1139/z02-128. ieee: J. Polechova and P. Stopka, “Geometry of social relationships in the Old World wood mouse, Apodemus sylvaticus,” Canadian Journal of Zoology, vol. 80, no. 8. NRC Research Press, pp. 1383–1388, 2002. ista: Polechova J, Stopka P. 2002. Geometry of social relationships in the Old World wood mouse, Apodemus sylvaticus. Canadian Journal of Zoology. 80(8), 1383–1388. mla: Polechova, Jitka, and P. Stopka. “Geometry of Social Relationships in the Old World Wood Mouse, Apodemus Sylvaticus.” Canadian Journal of Zoology, vol. 80, no. 8, NRC Research Press, 2002, pp. 1383–88, doi:10.1139/z02-128. short: J. Polechova, P. Stopka, Canadian Journal of Zoology 80 (2002) 1383–1388. date_created: 2018-12-11T12:07:10Z date_published: 2002-01-01T00:00:00Z date_updated: 2023-06-07T12:53:35Z day: '01' doi: 10.1139/z02-128 extern: '1' intvolume: ' 80' issue: '8' language: - iso: eng month: '01' oa_version: None page: 1383 - 1388 publication: Canadian Journal of Zoology publication_identifier: issn: - 0008-4301 publication_status: published publisher: NRC Research Press publist_id: '1981' quality_controlled: '1' scopus_import: '1' status: public title: Geometry of social relationships in the Old World wood mouse, Apodemus sylvaticus type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 80 year: '2002' ... --- _id: '4003' abstract: - lang: eng text: The writhing number measures the global geometry of a closed space curve or knot. We show that this measure is related to the average winding number of its Gauss map. Using this relationship, we give an algorithm for computing the writhing number for a polygonal knot with n edges in time roughly proportional to n(1.6). We also implement a different, simple algorithm and provide experimental evidence for its practical efficiency. acknowledgement: NSF under grants CCR-00-86013 and EIA-9972879, NSF under grant CCR-97-12088. article_processing_charge: No author: - first_name: Pankaj full_name: Agarwal, Pankaj last_name: Agarwal - first_name: Herbert full_name: Edelsbrunner, Herbert id: 3FB178DA-F248-11E8-B48F-1D18A9856A87 last_name: Edelsbrunner orcid: 0000-0002-9823-6833 - first_name: Yusu full_name: Wang, Yusu last_name: Wang citation: ama: 'Agarwal P, Edelsbrunner H, Wang Y. Computing the writhing number of a polygonal knot. In: Proceedings of the 13th Annual ACM-SIAM Symposium on Discrete Algorithms. SIAM; 2002:791-799.' apa: 'Agarwal, P., Edelsbrunner, H., & Wang, Y. (2002). Computing the writhing number of a polygonal knot. In Proceedings of the 13th annual ACM-SIAM symposium on Discrete algorithms (pp. 791–799). San Francisco, CA, USA: SIAM.' chicago: Agarwal, Pankaj, Herbert Edelsbrunner, and Yusu Wang. “Computing the Writhing Number of a Polygonal Knot.” In Proceedings of the 13th Annual ACM-SIAM Symposium on Discrete Algorithms, 791–99. SIAM, 2002. ieee: P. Agarwal, H. Edelsbrunner, and Y. Wang, “Computing the writhing number of a polygonal knot,” in Proceedings of the 13th annual ACM-SIAM symposium on Discrete algorithms, San Francisco, CA, USA, 2002, pp. 791–799. ista: 'Agarwal P, Edelsbrunner H, Wang Y. 2002. Computing the writhing number of a polygonal knot. Proceedings of the 13th annual ACM-SIAM symposium on Discrete algorithms. SODA: Symposium on Discrete Algorithms, 791–799.' mla: Agarwal, Pankaj, et al. “Computing the Writhing Number of a Polygonal Knot.” Proceedings of the 13th Annual ACM-SIAM Symposium on Discrete Algorithms, SIAM, 2002, pp. 791–99. short: P. Agarwal, H. Edelsbrunner, Y. Wang, in:, Proceedings of the 13th Annual ACM-SIAM Symposium on Discrete Algorithms, SIAM, 2002, pp. 791–799. conference: end_date: 2002-01-08 location: San Francisco, CA, USA name: 'SODA: Symposium on Discrete Algorithms' start_date: 2002-01-06 date_created: 2018-12-11T12:06:23Z date_published: 2002-01-01T00:00:00Z date_updated: 2023-06-07T13:50:04Z day: '01' extern: '1' language: - iso: eng main_file_link: - url: https://dl.acm.org/doi/10.5555/545381.545485 month: '01' oa_version: None page: 791 - 799 publication: Proceedings of the 13th annual ACM-SIAM symposium on Discrete algorithms publication_identifier: isbn: - '9780898715132' publication_status: published publisher: SIAM publist_id: '2125' quality_controlled: '1' scopus_import: '1' status: public title: Computing the writhing number of a polygonal knot type: conference user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 year: '2002' ... --- _id: '3995' abstract: - lang: eng text: This article is a survey of research areas in which motion plays a pivotal role. The aim of the article is to review current approaches to modeling motion together with related data structures and algorithms, and to summarize the challenges that lie ahead in producing a more unified theory of motion representation that would be useful across several disciplines. acknowledgement: "This article is based on the report of the Workshop on Algorithmic Issues in Modeling Motion, sponsored\r\nby an NSF grant CCR-00-83-033 and an Army Research Office grant DAAD 19-00-1-0478, held on August 6\r\nand 7, 2000 at Duke University, Durham, NC." article_processing_charge: No article_type: original author: - first_name: Pankaj full_name: Agarwal, Pankaj last_name: Agarwal - first_name: Leonidas full_name: Guibas, Leonidas last_name: Guibas - first_name: Herbert full_name: Edelsbrunner, Herbert id: 3FB178DA-F248-11E8-B48F-1D18A9856A87 last_name: Edelsbrunner orcid: 0000-0002-9823-6833 - first_name: Jeff full_name: Erickson, Jeff last_name: Erickson - first_name: Michael full_name: Isard, Michael last_name: Isard - first_name: Sariel full_name: Har Peled, Sariel last_name: Har Peled - first_name: John full_name: Hershberger, John last_name: Hershberger - first_name: Christian full_name: Jensen, Christian last_name: Jensen - first_name: Lydia full_name: Kavraki, Lydia last_name: Kavraki - first_name: Patrice full_name: Koehl, Patrice last_name: Koehl - first_name: Ming full_name: Lin, Ming last_name: Lin - first_name: Dinesh full_name: Manocha, Dinesh last_name: Manocha - first_name: Dimitris full_name: Metaxas, Dimitris last_name: Metaxas - first_name: Brian full_name: Mirtich, Brian last_name: Mirtich - first_name: David full_name: Mount, David last_name: Mount - first_name: Sankara full_name: Muthukrishnan, Sankara last_name: Muthukrishnan - first_name: Dinesh full_name: Pai, Dinesh last_name: Pai - first_name: Elisha full_name: Sacks, Elisha last_name: Sacks - first_name: Jack full_name: Snoeyink, Jack last_name: Snoeyink - first_name: Subhash full_name: Suri, Subhash last_name: Suri - first_name: Ouri full_name: Wolefson, Ouri last_name: Wolefson citation: ama: Agarwal P, Guibas L, Edelsbrunner H, et al. Algorithmic issues in modeling motion. ACM Computing Surveys. 2002;34(4):550-572. doi:10.1145/592642.592647 apa: Agarwal, P., Guibas, L., Edelsbrunner, H., Erickson, J., Isard, M., Har Peled, S., … Wolefson, O. (2002). Algorithmic issues in modeling motion. ACM Computing Surveys. ACM. https://doi.org/10.1145/592642.592647 chicago: Agarwal, Pankaj, Leonidas Guibas, Herbert Edelsbrunner, Jeff Erickson, Michael Isard, Sariel Har Peled, John Hershberger, et al. “Algorithmic Issues in Modeling Motion.” ACM Computing Surveys. ACM, 2002. https://doi.org/10.1145/592642.592647. ieee: P. Agarwal et al., “Algorithmic issues in modeling motion,” ACM Computing Surveys, vol. 34, no. 4. ACM, pp. 550–572, 2002. ista: Agarwal P, Guibas L, Edelsbrunner H, Erickson J, Isard M, Har Peled S, Hershberger J, Jensen C, Kavraki L, Koehl P, Lin M, Manocha D, Metaxas D, Mirtich B, Mount D, Muthukrishnan S, Pai D, Sacks E, Snoeyink J, Suri S, Wolefson O. 2002. Algorithmic issues in modeling motion. ACM Computing Surveys. 34(4), 550–572. mla: Agarwal, Pankaj, et al. “Algorithmic Issues in Modeling Motion.” ACM Computing Surveys, vol. 34, no. 4, ACM, 2002, pp. 550–72, doi:10.1145/592642.592647. short: P. Agarwal, L. Guibas, H. Edelsbrunner, J. Erickson, M. Isard, S. Har Peled, J. Hershberger, C. Jensen, L. Kavraki, P. Koehl, M. Lin, D. Manocha, D. Metaxas, B. Mirtich, D. Mount, S. Muthukrishnan, D. Pai, E. Sacks, J. Snoeyink, S. Suri, O. Wolefson, ACM Computing Surveys 34 (2002) 550–572. date_created: 2018-12-11T12:06:20Z date_published: 2002-12-01T00:00:00Z date_updated: 2023-06-13T11:34:25Z day: '01' doi: 10.1145/592642.592647 extern: '1' intvolume: ' 34' issue: '4' language: - iso: eng month: '12' oa_version: None page: 550 - 572 publication: ACM Computing Surveys publication_identifier: issn: - 0360-0300 publication_status: published publisher: ACM publist_id: '2129' quality_controlled: '1' scopus_import: '1' status: public title: Algorithmic issues in modeling motion type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 34 year: '2002' ... --- _id: '4000' abstract: - lang: eng text: We present fast implementations of a hybrid algorithm for reporting box and cube intersections. Our algorithm initially takes a divide-and-conquer approach and switches to simpler algorithms for low numbers of boxes. We use our implementations as engines to solve problems about geometric primitives. We look at two such problems in the category of quality analysis of surface triangulations. acknowledgement: Center for Simulation of Advanced Rockets funded by the U.S. Department of Energy under Subcontract B341494, NSF under grant CCR-96-19542 and ARO under grant DAAG55-98-1-0177. article_processing_charge: No article_type: original author: - first_name: Afra full_name: Zomorodian, Afra last_name: Zomorodian - first_name: Herbert full_name: Edelsbrunner, Herbert id: 3FB178DA-F248-11E8-B48F-1D18A9856A87 last_name: Edelsbrunner orcid: 0000-0002-9823-6833 citation: ama: Zomorodian A, Edelsbrunner H. Fast software for box intersections. International Journal of Computational Geometry and Applications. 2002;12(1-2):143-172. doi:10.1142/S0218195902000785 apa: Zomorodian, A., & Edelsbrunner, H. (2002). Fast software for box intersections. International Journal of Computational Geometry and Applications. World Scientific Publishing. https://doi.org/10.1142/S0218195902000785 chicago: Zomorodian, Afra, and Herbert Edelsbrunner. “Fast Software for Box Intersections.” International Journal of Computational Geometry and Applications. World Scientific Publishing, 2002. https://doi.org/10.1142/S0218195902000785. ieee: A. Zomorodian and H. Edelsbrunner, “Fast software for box intersections,” International Journal of Computational Geometry and Applications, vol. 12, no. 1–2. World Scientific Publishing, pp. 143–172, 2002. ista: Zomorodian A, Edelsbrunner H. 2002. Fast software for box intersections. International Journal of Computational Geometry and Applications. 12(1–2), 143–172. mla: Zomorodian, Afra, and Herbert Edelsbrunner. “Fast Software for Box Intersections.” International Journal of Computational Geometry and Applications, vol. 12, no. 1–2, World Scientific Publishing, 2002, pp. 143–72, doi:10.1142/S0218195902000785. short: A. Zomorodian, H. Edelsbrunner, International Journal of Computational Geometry and Applications 12 (2002) 143–172. date_created: 2018-12-11T12:06:22Z date_published: 2002-01-01T00:00:00Z date_updated: 2023-06-13T11:20:09Z day: '01' doi: 10.1142/S0218195902000785 extern: '1' intvolume: ' 12' issue: 1-2 language: - iso: eng month: '01' oa_version: None page: 143 - 172 publication: International Journal of Computational Geometry and Applications publication_identifier: issn: - 0218-1959 publication_status: published publisher: World Scientific Publishing publist_id: '2128' quality_controlled: '1' scopus_import: '1' status: public title: Fast software for box intersections type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 12 year: '2002' ... --- _id: '3998' abstract: - lang: eng text: We present results on a two-step improvement of mesh quality in three-dimensional Delaunay triangulations. The first step refines the triangulation by inserting sinks and eliminates tetrahedra with large circumradius over shortest edge length ratio. The second step assigns weights to the vertices to eliminate slivers. Our experimental findings provide evidence for the practical effectiveness of sliver exudation. acknowledgement: NSF under grants CCR-97-12088 and DMS 98-73945, NSF under grands EIA-9972879 and CCR-00-86013 and by ARO under grant DAAG55-98-1- 0177. article_processing_charge: No article_type: original author: - first_name: Herbert full_name: Edelsbrunner, Herbert id: 3FB178DA-F248-11E8-B48F-1D18A9856A87 last_name: Edelsbrunner orcid: 0000-0002-9823-6833 - first_name: Damrong full_name: Guoy, Damrong last_name: Guoy citation: ama: Edelsbrunner H, Guoy D. An experimental study of sliver exudation. Engineering with Computers. 2002;18(3):229-240. doi:10.1007/s003660200020 apa: Edelsbrunner, H., & Guoy, D. (2002). An experimental study of sliver exudation. Engineering with Computers. Springer. https://doi.org/10.1007/s003660200020 chicago: Edelsbrunner, Herbert, and Damrong Guoy. “An Experimental Study of Sliver Exudation.” Engineering with Computers. Springer, 2002. https://doi.org/10.1007/s003660200020. ieee: H. Edelsbrunner and D. Guoy, “An experimental study of sliver exudation,” Engineering with Computers, vol. 18, no. 3. Springer, pp. 229–240, 2002. ista: Edelsbrunner H, Guoy D. 2002. An experimental study of sliver exudation. Engineering with Computers. 18(3), 229–240. mla: Edelsbrunner, Herbert, and Damrong Guoy. “An Experimental Study of Sliver Exudation.” Engineering with Computers, vol. 18, no. 3, Springer, 2002, pp. 229–40, doi:10.1007/s003660200020. short: H. Edelsbrunner, D. Guoy, Engineering with Computers 18 (2002) 229–240. date_created: 2018-12-11T12:06:21Z date_published: 2002-10-01T00:00:00Z date_updated: 2023-06-13T11:14:44Z day: '01' doi: 10.1007/s003660200020 extern: '1' intvolume: ' 18' issue: '3' language: - iso: eng month: '10' oa_version: None page: 229 - 240 publication: Engineering with Computers publication_identifier: issn: - 0177-0667 publication_status: published publisher: Springer publist_id: '2126' quality_controlled: '1' scopus_import: '1' status: public title: An experimental study of sliver exudation type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 18 year: '2002' ... --- _id: '3802' abstract: - lang: eng text: The presynaptic Ca2+ signal is a key determinant of transmitter release at chemical synapses. In cortical synaptic terminals, however, little is known about the kinetic properties of the presynaptic Ca2+ channels. To investigate the timing and magnitude of the presynaptic Ca2+ inflow, we performed whole-cell patch-clamp recordings from mossy fiber boutons (MFBs) in rat hippocampus. MFBs showed large high-voltage-activated Ca(2+) currents, with a maximal amplitude of approximately 100 pA at a membrane potential of 0 mV. Both activation and deactivation were fast, with time constants in the submillisecond range at a temperature of approximately 23 degrees C. An MFB action potential (AP) applied as a voltage-clamp command evoked a transient Ca2+ current with an average amplitude of approximately 170 pA and a half-duration of 580 microsec. A prepulse to +40 mV had only minimal effects on the AP-evoked Ca2+ current, indicating that presynaptic APs open the voltage-gated Ca2+ channels very effectively. On the basis of the experimental data, we developed a kinetic model with four closed states and one open state, linked by voltage-dependent rate constants. Simulations of the Ca2+ current could reproduce the experimental data, including the large amplitude and rapid time course of the current evoked by MFB APs. Furthermore, the simulations indicate that the shape of the presynaptic AP and the gating kinetics of the Ca2+ channels are tuned to produce a maximal Ca2+ influx during a minimal period of time. The precise timing and high efficacy of Ca2+ channel activation at this cortical glutamatergic synapse may be important for synchronous transmitter release and temporal information processing. acknowledgement: J.B. was supported by grants from the Deutsche Forschungsgemeinschaft (Bi 642/1-2 and SFB 505/C9). We thank Dr. U. Kraushaar, Dr. S. Hefft, and C. Schmidt-Hieber for critically reading this manuscript, F. Heyde for secretarial help, and A. Blomenkamp and K. Winterhalter for technical assistance. article_processing_charge: No article_type: original author: - first_name: Josef full_name: Bischofberger, Josef last_name: Bischofberger - first_name: Jörg full_name: Geiger, Jörg last_name: Geiger - first_name: Peter M full_name: Jonas, Peter M id: 353C1B58-F248-11E8-B48F-1D18A9856A87 last_name: Jonas orcid: 0000-0001-5001-4804 citation: ama: Bischofberger J, Geiger J, Jonas PM. Timing and efficacy of Ca(2+) channel activation in hippocampal mossy fiber boutons. Journal of Neuroscience. 2002;22(24):10593-10602. doi:10.1523/JNEUROSCI.22-24-10593.2002 apa: Bischofberger, J., Geiger, J., & Jonas, P. M. (2002). Timing and efficacy of Ca(2+) channel activation in hippocampal mossy fiber boutons. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.22-24-10593.2002 chicago: Bischofberger, Josef, Jörg Geiger, and Peter M Jonas. “Timing and Efficacy of Ca(2+) Channel Activation in Hippocampal Mossy Fiber Boutons.” Journal of Neuroscience. Society for Neuroscience, 2002. https://doi.org/10.1523/JNEUROSCI.22-24-10593.2002. ieee: J. Bischofberger, J. Geiger, and P. M. Jonas, “Timing and efficacy of Ca(2+) channel activation in hippocampal mossy fiber boutons,” Journal of Neuroscience, vol. 22, no. 24. Society for Neuroscience, pp. 10593–10602, 2002. ista: Bischofberger J, Geiger J, Jonas PM. 2002. Timing and efficacy of Ca(2+) channel activation in hippocampal mossy fiber boutons. Journal of Neuroscience. 22(24), 10593–10602. mla: Bischofberger, Josef, et al. “Timing and Efficacy of Ca(2+) Channel Activation in Hippocampal Mossy Fiber Boutons.” Journal of Neuroscience, vol. 22, no. 24, Society for Neuroscience, 2002, pp. 10593–602, doi:10.1523/JNEUROSCI.22-24-10593.2002. short: J. Bischofberger, J. Geiger, P.M. Jonas, Journal of Neuroscience 22 (2002) 10593–10602. date_created: 2018-12-11T12:05:15Z date_published: 2002-12-01T00:00:00Z date_updated: 2023-06-13T13:19:45Z day: '01' doi: 10.1523/JNEUROSCI.22-24-10593.2002 extern: '1' external_id: pmid: - '12486151' intvolume: ' 22' issue: '24' language: - iso: eng main_file_link: - open_access: '1' url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6758411/ month: '12' oa: 1 oa_version: Published Version page: 10593 - 10602 pmid: 1 publication: Journal of Neuroscience publication_identifier: issn: - 0270-6474 publication_status: published publisher: Society for Neuroscience publist_id: '2407' quality_controlled: '1' scopus_import: '1' status: public title: Timing and efficacy of Ca(2+) channel activation in hippocampal mossy fiber boutons type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 22 year: '2002' ... --- _id: '3919' abstract: - lang: eng text: Hamilton's concept of local mate competition (LMC) is the standard model to explain female-biased sex ratios in solitary Hymenoptera. In social Hymenoptera, however, LMC has remained controversial, mainly because manipulation of sex allocation by workers in response to relatedness asymmetries is an additional powerful mechanism of female bias. Furthermore, the predominant mating systems in the social insects are thought to make LMC unlikely. Nevertheless, several species exist in which dispersal of males is limited and mating occurs in the nest. Some of these species, such as the ant Cardiocondyla obscurior, have evolved dimorphic males, with one morph being specialized for dispersal and the other for fighting with nest-mate males over access to females. Such life history, combining sociality and alternative reproductive tactics in males, provides a unique opportunity to test the power of LMC as a selective force leading to female-biased sex ratios in social Hymenoptera. We show that, in concordance with LMC predictions, an experimental increase in queen number leads to a shift in sex allocation in favour of non-dispersing males, but does not influence the proportion of disperser males. Furthermore, we can assign this change in sex allocation at the colony level to the queens and rule out worker manipulation. acknowledgement: 'We thank A. F. G. Bourke, J. J. Boomsma, S. Foitzik, M. Sixt,C. Anderson and C. Schubart for improving the manuscript, and E. Sixt for ant illustrations (figure 2). This study was funded by the DFG (Deutsche Forschungsgemeinschaft: He1623/7-2).' article_processing_charge: No article_type: original author: - first_name: Sylvia full_name: Cremer, Sylvia id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87 last_name: Cremer orcid: 0000-0002-2193-3868 - first_name: Jürgen full_name: Heinze, Jürgen last_name: Heinze citation: ama: 'Cremer S, Heinze J. Adaptive production of fighter males: queens of the ant Cardiocondyla adjust the sex ratio under local mate competition. Proceedings of the Royal Society of London Series B Biological Sciences. 2002;269(1489):417-422. doi:10.1098/rspb.2001.1892' apa: 'Cremer, S., & Heinze, J. (2002). Adaptive production of fighter males: queens of the ant Cardiocondyla adjust the sex ratio under local mate competition. Proceedings of the Royal Society of London Series B Biological Sciences. Royal Society, The. https://doi.org/10.1098/rspb.2001.1892' chicago: 'Cremer, Sylvia, and Jürgen Heinze. “Adaptive Production of Fighter Males: Queens of the Ant Cardiocondyla Adjust the Sex Ratio under Local Mate Competition.” Proceedings of the Royal Society of London Series B Biological Sciences. Royal Society, The, 2002. https://doi.org/10.1098/rspb.2001.1892.' ieee: 'S. Cremer and J. Heinze, “Adaptive production of fighter males: queens of the ant Cardiocondyla adjust the sex ratio under local mate competition,” Proceedings of the Royal Society of London Series B Biological Sciences, vol. 269, no. 1489. Royal Society, The, pp. 417–422, 2002.' ista: 'Cremer S, Heinze J. 2002. Adaptive production of fighter males: queens of the ant Cardiocondyla adjust the sex ratio under local mate competition. Proceedings of the Royal Society of London Series B Biological Sciences. 269(1489), 417–422.' mla: 'Cremer, Sylvia, and Jürgen Heinze. “Adaptive Production of Fighter Males: Queens of the Ant Cardiocondyla Adjust the Sex Ratio under Local Mate Competition.” Proceedings of the Royal Society of London Series B Biological Sciences, vol. 269, no. 1489, Royal Society, The, 2002, pp. 417–22, doi:10.1098/rspb.2001.1892.' short: S. Cremer, J. Heinze, Proceedings of the Royal Society of London Series B Biological Sciences 269 (2002) 417–422. date_created: 2018-12-11T12:05:53Z date_published: 2002-02-22T00:00:00Z date_updated: 2023-06-13T11:52:17Z day: '22' doi: 10.1098/rspb.2001.1892 extern: '1' external_id: pmid: - '11886631' intvolume: ' 269' issue: '1489' language: - iso: eng main_file_link: - open_access: '1' url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1690910/ month: '02' oa: 1 oa_version: None page: 417 - 422 pmid: 1 publication: Proceedings of the Royal Society of London Series B Biological Sciences publication_identifier: issn: - 0962-8452 publication_status: published publisher: Royal Society, The publist_id: '2231' quality_controlled: '1' scopus_import: '1' status: public title: 'Adaptive production of fighter males: queens of the ant Cardiocondyla adjust the sex ratio under local mate competition' type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 269 year: '2002' ... --- _id: '3924' abstract: - lang: eng text: 'Males of the ant Cardiocondyla show a dispersal dimorphism of a winged and wingless morph. The loss of flight has lead to morphological reductions in the wingless (ergatoid) males and also affected body size, eye size and pigmentation. As ergatoid males mate exclusively inside the maternal nest, they underlie increased male-male competition and therefore have also evolved additional changes in behaviour and physiology: in contrast to winged males, ergatoid males are highly aggressive towards each other and their spermatogenesis is prolonged compared to all other hymenopteran males. In addition to these two male morphs, we found males with an intermediate appearance. These "intermorphic" males provide a transitional stage between normal males in most investigated morphological and physiological parameters. As they are produced extremely rarely and only in colonies that switch between pure ergatoid to mixed male production, we argue that they likely represent a developmental mistake. Parallels between the determination of male morphs and female castes (queen-worker dimorphism and worker polymorphism) might help to understand how the large potential of phenotypic plasticity in both sexes of social insects is realised during development.' acknowledgement: We would like to thank S. Karpeles for histological analysis of the winged males and S. Buchhauser for help with the photographs. This study was funded by the DFG (grant He1623/12–1). article_processing_charge: No article_type: original author: - first_name: Sylvia full_name: Cremer, Sylvia id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87 last_name: Cremer orcid: 0000-0002-2193-3868 - first_name: Birgit full_name: Lautenschläger, Birgit last_name: Lautenschläger - first_name: Jürgen full_name: Heinze, Jürgen last_name: Heinze citation: ama: Cremer S, Lautenschläger B, Heinze J. A transitional stage between the ergatoid and winged male morph in the ant Cardiocondyla obscurior. Insectes Sociaux. 2002;49(3):221-228. doi:10.1007/s00040-002-8305-z apa: Cremer, S., Lautenschläger, B., & Heinze, J. (2002). A transitional stage between the ergatoid and winged male morph in the ant Cardiocondyla obscurior. Insectes Sociaux. Springer. https://doi.org/10.1007/s00040-002-8305-z chicago: Cremer, Sylvia, Birgit Lautenschläger, and Jürgen Heinze. “A Transitional Stage between the Ergatoid and Winged Male Morph in the Ant Cardiocondyla Obscurior.” Insectes Sociaux. Springer, 2002. https://doi.org/10.1007/s00040-002-8305-z. ieee: S. Cremer, B. Lautenschläger, and J. Heinze, “A transitional stage between the ergatoid and winged male morph in the ant Cardiocondyla obscurior,” Insectes Sociaux, vol. 49, no. 3. Springer, pp. 221–228, 2002. ista: Cremer S, Lautenschläger B, Heinze J. 2002. A transitional stage between the ergatoid and winged male morph in the ant Cardiocondyla obscurior. Insectes Sociaux. 49(3), 221–228. mla: Cremer, Sylvia, et al. “A Transitional Stage between the Ergatoid and Winged Male Morph in the Ant Cardiocondyla Obscurior.” Insectes Sociaux, vol. 49, no. 3, Springer, 2002, pp. 221–28, doi:10.1007/s00040-002-8305-z. short: S. Cremer, B. Lautenschläger, J. Heinze, Insectes Sociaux 49 (2002) 221–228. date_created: 2018-12-11T12:05:55Z date_published: 2002-04-05T00:00:00Z date_updated: 2023-06-13T11:44:08Z day: '05' doi: 10.1007/s00040-002-8305-z extern: '1' intvolume: ' 49' issue: '3' language: - iso: eng month: '04' oa_version: None page: 221 - 228 publication: Insectes Sociaux publication_identifier: issn: - 0020-1812 publication_status: published publisher: Springer publist_id: '2229' quality_controlled: '1' scopus_import: '1' status: public title: A transitional stage between the ergatoid and winged male morph in the ant Cardiocondyla obscurior type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 49 year: '2002' ... --- _id: '3925' abstract: - lang: eng text: Males of the tropical ant Cardiocondyla obscurior are either wingless and aggressive or winged and docile, and both compete for access to virgin queens in the nest1, 2. Although the fighter males (ergatoids) attack and kill other ergatoids, they tolerate and even attempt to mate with their winged rivals. Here we show that the winged males avoid the aggression of wingless males by mimicking the chemical bouquet of virgin queens, but that their mating success is not reduced as a result. This example of female mimicry by vigorous males is surprising, as in other species it is typically used as a protective strategy by weaker males, and may explain the coexistence and equal mating success of two male morphs. article_processing_charge: No article_type: original author: - first_name: Sylvia full_name: Cremer, Sylvia id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87 last_name: Cremer orcid: 0000-0002-2193-3868 - first_name: Matthew full_name: Sledge, Matthew last_name: Sledge - first_name: Jürgen full_name: Heinze, Jürgen last_name: Heinze citation: ama: 'Cremer S, Sledge M, Heinze J. Chemical mimicry: Male ants disguised by the queen’s bouquet. Nature. 2002;419:897-897. doi:10.1038/419897a' apa: 'Cremer, S., Sledge, M., & Heinze, J. (2002). Chemical mimicry: Male ants disguised by the queen’s bouquet. Nature. Nature Publishing Group. https://doi.org/10.1038/419897a' chicago: 'Cremer, Sylvia, Matthew Sledge, and Jürgen Heinze. “Chemical Mimicry: Male Ants Disguised by the Queen’s Bouquet.” Nature. Nature Publishing Group, 2002. https://doi.org/10.1038/419897a.' ieee: 'S. Cremer, M. Sledge, and J. Heinze, “Chemical mimicry: Male ants disguised by the queen’s bouquet,” Nature, vol. 419. Nature Publishing Group, pp. 897–897, 2002.' ista: 'Cremer S, Sledge M, Heinze J. 2002. Chemical mimicry: Male ants disguised by the queen’s bouquet. Nature. 419, 897–897.' mla: 'Cremer, Sylvia, et al. “Chemical Mimicry: Male Ants Disguised by the Queen’s Bouquet.” Nature, vol. 419, Nature Publishing Group, 2002, pp. 897–897, doi:10.1038/419897a.' short: S. Cremer, M. Sledge, J. Heinze, Nature 419 (2002) 897–897. date_created: 2018-12-11T12:05:55Z date_published: 2002-10-31T00:00:00Z date_updated: 2023-06-13T11:47:19Z day: '31' doi: 10.1038/419897a extern: '1' external_id: pmid: - '12410300' intvolume: ' 419' language: - iso: eng month: '10' oa_version: None page: 897 - 897 pmid: 1 publication: Nature publication_identifier: issn: - 0028-0836 publication_status: published publisher: Nature Publishing Group publist_id: '2230' quality_controlled: '1' scopus_import: '1' status: public title: 'Chemical mimicry: Male ants disguised by the queen''s bouquet' type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 419 year: '2002' ... --- _id: '3996' abstract: - lang: eng text: We formalize a notion of topological simplification within the framework of a filtration, which is the history of a growing complex. We classify a topological change that happens during growth as either a feature or noise depending on its lifetime or persistence within the filtration. We give fast algorithms for computing persistence and experimental evidence for their speed and utility. acknowledgement: "We thank Jeff Erickson and John Harer for helpful discussions during early stages of this\r\npaper. We also thank Daniel Huson for the zeolite dataset Z, Thomas LaBean for the DNA\r\ndataset D, and the Stanford Graphics Lab for the Buddha dataset S. To generate the bone\r\ndataset B, we sampled an iso-surface generated by Dominique Attali. The volume data\r\nTopological Persistence and Simplification 533 was provided by Francoise Peyrin from CNRS CREATIS in Lyon and was issued from ¸ Synchrotron Radiation Microtomography from the ID19 beamline at ESRF in Grenoble.\r\nWe generated Fig. 17 using the Protein Explorer [6]." article_processing_charge: No article_type: original author: - first_name: Herbert full_name: Edelsbrunner, Herbert id: 3FB178DA-F248-11E8-B48F-1D18A9856A87 last_name: Edelsbrunner orcid: 0000-0002-9823-6833 - first_name: David full_name: Letscher, David last_name: Letscher - first_name: Afra full_name: Zomorodian, Afra last_name: Zomorodian citation: ama: Edelsbrunner H, Letscher D, Zomorodian A. Topological persistence and simplification. Discrete & Computational Geometry. 2002;28(4):511-533. doi:10.1007/s00454-002-2885-2 apa: Edelsbrunner, H., Letscher, D., & Zomorodian, A. (2002). Topological persistence and simplification. Discrete & Computational Geometry. Springer. https://doi.org/10.1007/s00454-002-2885-2 chicago: Edelsbrunner, Herbert, David Letscher, and Afra Zomorodian. “Topological Persistence and Simplification.” Discrete & Computational Geometry. Springer, 2002. https://doi.org/10.1007/s00454-002-2885-2. ieee: H. Edelsbrunner, D. Letscher, and A. Zomorodian, “Topological persistence and simplification,” Discrete & Computational Geometry, vol. 28, no. 4. Springer, pp. 511–533, 2002. ista: Edelsbrunner H, Letscher D, Zomorodian A. 2002. Topological persistence and simplification. Discrete & Computational Geometry. 28(4), 511–533. mla: Edelsbrunner, Herbert, et al. “Topological Persistence and Simplification.” Discrete & Computational Geometry, vol. 28, no. 4, Springer, 2002, pp. 511–33, doi:10.1007/s00454-002-2885-2. short: H. Edelsbrunner, D. Letscher, A. Zomorodian, Discrete & Computational Geometry 28 (2002) 511–533. date_created: 2018-12-11T12:06:20Z date_published: 2002-12-01T00:00:00Z date_updated: 2023-06-13T11:41:19Z day: '01' doi: 10.1007/s00454-002-2885-2 extern: '1' intvolume: ' 28' issue: '4' language: - iso: eng month: '12' oa_version: None page: 511 - 533 publication: Discrete & Computational Geometry publication_identifier: issn: - 0179-5376 publication_status: published publisher: Springer publist_id: '2130' quality_controlled: '1' scopus_import: '1' status: public title: Topological persistence and simplification type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 28 year: '2002' ... --- _id: '3920' abstract: - lang: eng text: A particular Solid Injector needle, suitable for GC-MS analyses of small specimens, is described together with its application in a study on ants. acknowledgement: "We thank Giancarlo Bucelli and Gloriano Moneti (Centro Interdipartimentale\r\ndi Spettrometria di Massa, Università di Firenze) for their help. Funding was\r\nprovided by the MURST “60%” and Italian CNR “40%” funds, as well as through\r\nthe research network “Social evolution” of the Universities of Aarhus, Firenze,\r\nKeele, Sheffield, Uppsala, Würzburg and the ETH of Zürich financed by the\r\nEuropean commission via the Training and Mobility of Researchers (TMR)\r\nprogramme. " article_processing_charge: No article_type: original author: - first_name: Stefano full_name: Turillazzi, Stefano last_name: Turillazzi - first_name: Matthew full_name: Sledge, Matthew last_name: Sledge - first_name: Sylvia full_name: Cremer, Sylvia id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87 last_name: Cremer orcid: 0000-0002-2193-3868 - first_name: Jürgen full_name: Heinze, Jürgen last_name: Heinze citation: ama: Turillazzi S, Sledge M, Cremer S, Heinze J. A method for analysing small-size specimens in GC-MS. Insect Social Life. 2002;4:169-175. apa: Turillazzi, S., Sledge, M., Cremer, S., & Heinze, J. (2002). A method for analysing small-size specimens in GC-MS. Insect Social Life. Elsevier. chicago: Turillazzi, Stefano, Matthew Sledge, Sylvia Cremer, and Jürgen Heinze. “A Method for Analysing Small-Size Specimens in GC-MS.” Insect Social Life. Elsevier, 2002. ieee: S. Turillazzi, M. Sledge, S. Cremer, and J. Heinze, “A method for analysing small-size specimens in GC-MS,” Insect Social Life, vol. 4. Elsevier, pp. 169–175, 2002. ista: Turillazzi S, Sledge M, Cremer S, Heinze J. 2002. A method for analysing small-size specimens in GC-MS. Insect Social Life. 4, 169–175. mla: Turillazzi, Stefano, et al. “A Method for Analysing Small-Size Specimens in GC-MS.” Insect Social Life, vol. 4, Elsevier, 2002, pp. 169–75. short: S. Turillazzi, M. Sledge, S. Cremer, J. Heinze, Insect Social Life 4 (2002) 169–175. date_created: 2018-12-11T12:05:54Z date_published: 2002-01-01T00:00:00Z date_updated: 2023-06-13T12:57:06Z day: '01' extern: '1' intvolume: ' 4' language: - iso: eng month: '01' oa_version: None page: 169 - 175 publication: Insect Social Life publication_status: published publisher: Elsevier publist_id: '2232' quality_controlled: '1' status: public title: A method for analysing small-size specimens in GC-MS type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 4 year: '2002' ... --- _id: '3800' abstract: - lang: eng text: Networks of GABAergic interneurons are of critical importance for the generation of gamma frequency oscillations in the brain. To examine the underlying synaptic mechanisms, we made paired recordings from "basket cells" (BCs) in different subfields of hippocampal slices, using transgenic mice that express enhanced green fluorescent protein (EGFP) under the control of the parvalbumin promoter. Unitary inhibitory postsynaptic currents (IPSCs) showed large amplitude and fast time course with mean amplitude-weighted decay time constants of 2.5, 1.2, and 1.8 ms in the dentate gyrus, and the cornu ammonis area 3 (CA3) and 1 (CA1), respectively (33-34 degrees C). The decay of unitary IPSCs at BC-BC synapses was significantly faster than that at BC-principal cell synapses, indicating target cell-specific differences in IPSC kinetics. In addition, electrical coupling was found in a subset of BC-BC pairs. To examine whether an interneuron network with fast inhibitory synapses can act as a gamma frequency oscillator, we developed an interneuron network model based on experimentally determined properties. In comparison to previous interneuron network models, our model was able to generate oscillatory activity with higher coherence over a broad range of frequencies (20-110 Hz). In this model, high coherence and flexibility in frequency control emerge from the combination of synaptic properties, network structure, and electrical coupling. acknowledgement: We thank Drs. J. Bischofberger, M. Heckmann, and R. Traub for critically reading the manuscript. This work was supported by Deutsche Forschungsgemeinschaft Grants SFB 505/C5 (to P.J.) and SFB 505/C6 (to M.F. and P.J.), Human Frontiers Science Program Organization Grant RG0017/1998-B (to P.J.), and grants from the Alexander-von-Humboldt Foundation (to P.J. and M.F.), the Schilling Foundation (to H.M.), and Novartis (to H.M.). article_processing_charge: No article_type: original author: - first_name: Marlene full_name: Bartos, Marlene last_name: Bartos - first_name: Imre full_name: Vida, Imre last_name: Vida - first_name: Michael full_name: Frotscher, Michael last_name: Frotscher - first_name: Axel full_name: Meyer, Axel last_name: Meyer - first_name: Hannah full_name: Monyer, Hannah last_name: Monyer - first_name: Jörg full_name: Geiger, Jörg last_name: Geiger - first_name: Peter M full_name: Jonas, Peter M id: 353C1B58-F248-11E8-B48F-1D18A9856A87 last_name: Jonas orcid: 0000-0001-5001-4804 citation: ama: Bartos M, Vida I, Frotscher M, et al. Fast synaptic inhibition promotes synchronized gamma oscillations in hippocampal interneuron networks. PNAS. 2002;99(20):13222-13227. doi:10.1073/pnas.192233099 apa: Bartos, M., Vida, I., Frotscher, M., Meyer, A., Monyer, H., Geiger, J., & Jonas, P. M. (2002). Fast synaptic inhibition promotes synchronized gamma oscillations in hippocampal interneuron networks. PNAS. National Academy of Sciences. https://doi.org/10.1073/pnas.192233099 chicago: Bartos, Marlene, Imre Vida, Michael Frotscher, Axel Meyer, Hannah Monyer, Jörg Geiger, and Peter M Jonas. “Fast Synaptic Inhibition Promotes Synchronized Gamma Oscillations in Hippocampal Interneuron Networks.” PNAS. National Academy of Sciences, 2002. https://doi.org/10.1073/pnas.192233099. ieee: M. Bartos et al., “Fast synaptic inhibition promotes synchronized gamma oscillations in hippocampal interneuron networks,” PNAS, vol. 99, no. 20. National Academy of Sciences, pp. 13222–13227, 2002. ista: Bartos M, Vida I, Frotscher M, Meyer A, Monyer H, Geiger J, Jonas PM. 2002. Fast synaptic inhibition promotes synchronized gamma oscillations in hippocampal interneuron networks. PNAS. 99(20), 13222–13227. mla: Bartos, Marlene, et al. “Fast Synaptic Inhibition Promotes Synchronized Gamma Oscillations in Hippocampal Interneuron Networks.” PNAS, vol. 99, no. 20, National Academy of Sciences, 2002, pp. 13222–27, doi:10.1073/pnas.192233099. short: M. Bartos, I. Vida, M. Frotscher, A. Meyer, H. Monyer, J. Geiger, P.M. Jonas, PNAS 99 (2002) 13222–13227. date_created: 2018-12-11T12:05:14Z date_published: 2002-09-16T00:00:00Z date_updated: 2023-07-10T13:35:18Z day: '16' doi: 10.1073/pnas.192233099 extern: '1' external_id: pmid: - '12235359' intvolume: ' 99' issue: '20' language: - iso: eng main_file_link: - open_access: '1' url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC130614/ month: '09' oa: 1 oa_version: Published Version page: 13222 - 13227 pmid: 1 publication: PNAS publication_identifier: issn: - 0027-8424 publication_status: published publisher: National Academy of Sciences publist_id: '2409' quality_controlled: '1' scopus_import: '1' status: public title: Fast synaptic inhibition promotes synchronized gamma oscillations in hippocampal interneuron networks type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 99 year: '2002' ... --- _id: '3803' abstract: - lang: eng text: Mossy fiber (MF) synapses are key stations for flow of information through the hippocampal formation. A major component of the output of the MF system is directed towards inhibitory interneurons. Recent studies have revealed that the functional properties of MF-interneuron synapses differ substantially from those of MF-CA3 pyramidal neuron synapses. Mossy-fiber-interneuron synapses in the stratum lucidum represent a continuum of functional subtypes, in which the subunit composition of postsynaptic AMPA receptors and NMDA receptors appears to be regulated in a coordinated manner. article_processing_charge: No article_type: letter_note author: - first_name: Josef full_name: Bischofberger, Josef last_name: Bischofberger - first_name: Peter M full_name: Jonas, Peter M id: 353C1B58-F248-11E8-B48F-1D18A9856A87 last_name: Jonas orcid: 0000-0001-5001-4804 citation: ama: 'Bischofberger J, Jonas PM. TwoB or not twoB: differential transmission at glutamatergic mossy fiber-interneuron synapses in the hippocampus. Trends in Neurosciences. 2002;25(12):600-603. doi:10.1016/S0166-2236(02)02259-2' apa: 'Bischofberger, J., & Jonas, P. M. (2002). TwoB or not twoB: differential transmission at glutamatergic mossy fiber-interneuron synapses in the hippocampus. Trends in Neurosciences. Elsevier. https://doi.org/10.1016/S0166-2236(02)02259-2' chicago: 'Bischofberger, Josef, and Peter M Jonas. “TwoB or Not TwoB: Differential Transmission at Glutamatergic Mossy Fiber-Interneuron Synapses in the Hippocampus.” Trends in Neurosciences. Elsevier, 2002. https://doi.org/10.1016/S0166-2236(02)02259-2.' ieee: 'J. Bischofberger and P. M. Jonas, “TwoB or not twoB: differential transmission at glutamatergic mossy fiber-interneuron synapses in the hippocampus,” Trends in Neurosciences, vol. 25, no. 12. Elsevier, pp. 600–603, 2002.' ista: 'Bischofberger J, Jonas PM. 2002. TwoB or not twoB: differential transmission at glutamatergic mossy fiber-interneuron synapses in the hippocampus. Trends in Neurosciences. 25(12), 600–603.' mla: 'Bischofberger, Josef, and Peter M. Jonas. “TwoB or Not TwoB: Differential Transmission at Glutamatergic Mossy Fiber-Interneuron Synapses in the Hippocampus.” Trends in Neurosciences, vol. 25, no. 12, Elsevier, 2002, pp. 600–03, doi:10.1016/S0166-2236(02)02259-2.' short: J. Bischofberger, P.M. Jonas, Trends in Neurosciences 25 (2002) 600–603. date_created: 2018-12-11T12:05:15Z date_published: 2002-12-01T00:00:00Z date_updated: 2023-07-10T13:22:24Z day: '01' doi: 10.1016/S0166-2236(02)02259-2 extern: '1' external_id: pmid: - '12446120' intvolume: ' 25' issue: '12' language: - iso: eng month: '12' oa_version: None page: 600 - 603 pmid: 1 publication: Trends in Neurosciences publication_identifier: issn: - 0166-2236 publication_status: published publisher: Elsevier publist_id: '2408' quality_controlled: '1' status: public title: 'TwoB or not twoB: differential transmission at glutamatergic mossy fiber-interneuron synapses in the hippocampus' type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 25 year: '2002' ... --- _id: '3801' abstract: - lang: eng text: 'To examine possible interactions between fast depression and modulation of inhibitory synaptic transmission in the hippocampus, we recorded from pairs of synaptically connected basket cells (BCs) and granule cells (GCs) in the dentate gyrus of rat brain slices at 34 degrees C. Multiple-pulse depression (MPD) was examined in trains of 5 or 10 inhibitory postsynaptic currents (IPSCs) evoked at frequencies of 10-100 Hz under several conditions that inhibit transmitter release: block of voltage-dependent Ca2+ channels by Cd2+ (10 microM), activation of gamma-amino-butyric acid type B receptors (GABA(B)Rs) by baclofen (10 microM) and activation of muscarinic acetylcholine receptors (mAchRs) by carbachol (2 microM). All manipulations led to a substantial inhibition of synaptic transmission, reducing the amplitude of the first IPSC in the train (IPSC1) by 72%, 61% and 29%, respectively. However, MPD was largely preserved under these conditions (0.34 in control versus 0.31, 0.50 and 0.47 in the respective conditions at 50 Hz). Similarly, a theta burst stimulation (TBS) protocol reduced IPSC1 by 54%, but left MPD unchanged (0.40 in control and 0.39 during TBS). Analysis of both fractions of transmission failures and coefficients of variation (CV) of IPSC peak amplitudes suggested that MPD had a presynaptic expression site, independent of release probability. In conclusion, different types of presynaptic modulation of inhibitory synaptic transmission converge on a reduction of synaptic strength, while short-term dynamics are largely unchanged.' acknowledgement: We thank Drs M. Bartos, J. Bischofberger, M. Heckmann and I. Vida for critically reading the manuscript, Dr K. Götz for providing information about pharmacological properties of inhibitory hippocampal synapses, and A. Blomenkamp and K. Winterhalter for technical assistance. This work was supported by Deutsche Forschungsgemeinschaft grants to P.J. (Jo-248/2-2,SFB 505/C5) and the Alexander-von-Humboldt foundation. article_processing_charge: No article_type: original author: - first_name: Stefan full_name: Hefft, Stefan last_name: Hefft - first_name: Udo full_name: Kraushaar, Udo last_name: Kraushaar - first_name: Jörg full_name: Geiger, Jörg last_name: Geiger - first_name: Peter M full_name: Jonas, Peter M id: 353C1B58-F248-11E8-B48F-1D18A9856A87 last_name: Jonas orcid: 0000-0001-5001-4804 citation: ama: Hefft S, Kraushaar U, Geiger J, Jonas PM. Presynaptic short-term depression is maintained during regulation of transmitter release at a GABAergic synapse in rat hippocampus. Journal of Physiology. 2002;539(Pt 1):201-208. doi:10.1113/jphysiol.2001.013455 apa: Hefft, S., Kraushaar, U., Geiger, J., & Jonas, P. M. (2002). Presynaptic short-term depression is maintained during regulation of transmitter release at a GABAergic synapse in rat hippocampus. Journal of Physiology. Wiley-Blackwell. https://doi.org/10.1113/jphysiol.2001.013455 chicago: Hefft, Stefan, Udo Kraushaar, Jörg Geiger, and Peter M Jonas. “Presynaptic Short-Term Depression Is Maintained during Regulation of Transmitter Release at a GABAergic Synapse in Rat Hippocampus.” Journal of Physiology. Wiley-Blackwell, 2002. https://doi.org/10.1113/jphysiol.2001.013455. ieee: S. Hefft, U. Kraushaar, J. Geiger, and P. M. Jonas, “Presynaptic short-term depression is maintained during regulation of transmitter release at a GABAergic synapse in rat hippocampus,” Journal of Physiology, vol. 539, no. Pt 1. Wiley-Blackwell, pp. 201–8, 2002. ista: Hefft S, Kraushaar U, Geiger J, Jonas PM. 2002. Presynaptic short-term depression is maintained during regulation of transmitter release at a GABAergic synapse in rat hippocampus. Journal of Physiology. 539(Pt 1), 201–8. mla: Hefft, Stefan, et al. “Presynaptic Short-Term Depression Is Maintained during Regulation of Transmitter Release at a GABAergic Synapse in Rat Hippocampus.” Journal of Physiology, vol. 539, no. Pt 1, Wiley-Blackwell, 2002, pp. 201–08, doi:10.1113/jphysiol.2001.013455. short: S. Hefft, U. Kraushaar, J. Geiger, P.M. Jonas, Journal of Physiology 539 (2002) 201–8. date_created: 2018-12-11T12:05:15Z date_published: 2002-02-01T00:00:00Z date_updated: 2023-07-11T10:01:12Z day: '01' doi: 10.1113/jphysiol.2001.013455 extern: '1' external_id: pmid: - '11850513' intvolume: ' 539' issue: Pt 1 language: - iso: eng main_file_link: - open_access: '1' url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2290140/ month: '02' oa: 1 oa_version: Published Version page: 201 - 8 pmid: 1 publication: Journal of Physiology publication_identifier: issn: - 0022-3751 publication_status: published publisher: Wiley-Blackwell publist_id: '2410' quality_controlled: '1' scopus_import: '1' status: public title: Presynaptic short-term depression is maintained during regulation of transmitter release at a GABAergic synapse in rat hippocampus type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 539 year: '2002' ... --- _id: '3799' abstract: - lang: eng text: 'GABAergic interneurones are diverse in their morphological and functional properties. Perisomatic inhibitory cells show fast spiking during sustained current injection, whereas dendritic inhibitory cells fire action potentials with lower frequency. We examined functional and molecular properties of K(+) channels in interneurones with horizontal dendrites in stratum oriens-alveus (OA) of the hippocampal CA1 region, which mainly comprise somatostatin-positive dendritic inhibitory cells. Voltage-gated K(+) currents in nucleated patches isolated from OA interneurones consisted of three major components: a fast delayed rectifier K(+) current component that was highly sensitive to external 4-aminopyridine (4-AP) and tetraethylammonium (TEA) (half-maximal inhibitory concentrations < 0.1 mM for both blockers), a slow delayed rectifier K(+) current component that was sensitive to high concentrations of TEA, but insensitive to 4-AP, and a rapidly inactivating A-type K(+) current component that was blocked by high concentrations of 4-AP, but resistant to TEA. The relative contributions of these components to the macroscopic K(+) current were estimated as 57 +/- 5, 25 +/- 6, and 19 +/- 2 %, respectively. Dendrotoxin, a selective blocker of Kv1 channels had only minimal effects on K(+) currents in nucleated patches. Coapplication of the membrane-permeant cAMP analogue 8-(4-chlorophenylthio)-adenosine 3'':5''-cyclic monophosphate (cpt-cAMP) and the phosphodiesterase blocker isobutyl-methylxanthine (IBMX) resulted in a selective inhibition of the fast delayed rectifier K(+) current component. This inhibition was absent in the presence of the protein kinase A (PKA) inhibitor H-89, implying the involvement of PKA-mediated phosphorylation. Single-cell reverse transcription-polymerase chain reaction (RT-PCR) analysis revealed a high abundance of Kv3.2 mRNA in OA interneurones, whereas the expression level of Kv3.1 mRNA was markedly lower. Similarly, RT-PCR analysis showed a high abundance of Kv4.3 mRNA, whereas Kv4.2 mRNA was undetectable. This suggests that the fast delayed rectifier K(+) current and the A-type K(+) current component are mediated predominantly by homomeric Kv3.2 and Kv4.3 channels. Selective modulation of Kv3.2 channels in OA interneurones by cAMP is likely to be an important factor regulating the activity of dendritic inhibitory cells in principal neurone-interneurone microcircuits.' acknowledgement: We thank Drs J. Bischofberger, M. Heckmann, and I. Vida for critically reading the manuscript, and A. Blomenkamp and K. Winterhalter for technical assistance. This work was supported by a scholarship from the Deutscher Akademischer Austansch dienst to C.-C. L., a Deutsche Forschungsgemeinschaft grant to P. J. (SFB 505/C5), and the Alexander-von-Humboldt foundation. article_processing_charge: No article_type: original author: - first_name: Cheng full_name: Lien, Cheng last_name: Lien - first_name: Marco full_name: Martina, Marco last_name: Martina - first_name: Jobst full_name: Schultz, Jobst last_name: Schultz - first_name: Heimo full_name: Ehmke, Heimo last_name: Ehmke - first_name: Peter M full_name: Jonas, Peter M id: 353C1B58-F248-11E8-B48F-1D18A9856A87 last_name: Jonas orcid: 0000-0001-5001-4804 citation: ama: Lien C, Martina M, Schultz J, Ehmke H, Jonas PM. Gating, modulation and subunit composition of voltage-gated K(+) channels in dendritic inhibitory interneurones of rat hippocampus. Journal of Physiology. 2002;538(Pt 2):405-419. doi:10.1113/jphysiol.2001.013066 apa: Lien, C., Martina, M., Schultz, J., Ehmke, H., & Jonas, P. M. (2002). Gating, modulation and subunit composition of voltage-gated K(+) channels in dendritic inhibitory interneurones of rat hippocampus. Journal of Physiology. Wiley-Blackwell. https://doi.org/10.1113/jphysiol.2001.013066 chicago: Lien, Cheng, Marco Martina, Jobst Schultz, Heimo Ehmke, and Peter M Jonas. “Gating, Modulation and Subunit Composition of Voltage-Gated K(+) Channels in Dendritic Inhibitory Interneurones of Rat Hippocampus.” Journal of Physiology. Wiley-Blackwell, 2002. https://doi.org/10.1113/jphysiol.2001.013066. ieee: C. Lien, M. Martina, J. Schultz, H. Ehmke, and P. M. Jonas, “Gating, modulation and subunit composition of voltage-gated K(+) channels in dendritic inhibitory interneurones of rat hippocampus,” Journal of Physiology, vol. 538, no. Pt 2. Wiley-Blackwell, pp. 405–419, 2002. ista: Lien C, Martina M, Schultz J, Ehmke H, Jonas PM. 2002. Gating, modulation and subunit composition of voltage-gated K(+) channels in dendritic inhibitory interneurones of rat hippocampus. Journal of Physiology. 538(Pt 2), 405–419. mla: Lien, Cheng, et al. “Gating, Modulation and Subunit Composition of Voltage-Gated K(+) Channels in Dendritic Inhibitory Interneurones of Rat Hippocampus.” Journal of Physiology, vol. 538, no. Pt 2, Wiley-Blackwell, 2002, pp. 405–19, doi:10.1113/jphysiol.2001.013066. short: C. Lien, M. Martina, J. Schultz, H. Ehmke, P.M. Jonas, Journal of Physiology 538 (2002) 405–419. date_created: 2018-12-11T12:05:14Z date_published: 2002-01-01T00:00:00Z date_updated: 2023-07-11T12:32:26Z day: '01' doi: 10.1113/jphysiol.2001.013066 extern: '1' external_id: pmid: - '11790809' intvolume: ' 538' issue: Pt 2 language: - iso: eng main_file_link: - open_access: '1' url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2290075/ month: '01' oa: 1 oa_version: Published Version page: 405 - 419 pmid: 1 publication: Journal of Physiology publication_identifier: issn: - 0022-3751 publication_status: published publisher: Wiley-Blackwell publist_id: '2411' quality_controlled: '1' status: public title: Gating, modulation and subunit composition of voltage-gated K(+) channels in dendritic inhibitory interneurones of rat hippocampus type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 538 year: '2002' ... --- _id: '3621' abstract: - lang: eng text: In 1991, Barton and Turelli developed recursions to describe the evolution of multilocus systems under arbitrary forms of selection. This article generalizes their approach to allow for arbitrary modes of inheritance, including diploidy, polyploidy, sex linkage, cytoplasmic inheritance, and genomic imprinting. The framework is also extended to allow for other deterministic evolutionary forces, including migration and mutation. Exact recursions that fully describe the state of the population are presented; these are implemented in a computer algebra package (available on the Web at http://helios.bto.ed.ac.uk/evolgen). Despite the generality of our framework, it can describe evolutionary dynamics exactly by just two equations. These recursions can be further simplified using a "quasi-linkage equilibrium" (QLE) approximation. We illustrate the methods by finding the effect of natural selection, sexual selection, mutation, and migration on the genetic composition of a population. article_processing_charge: No article_type: original author: - first_name: Mark full_name: Kirkpatrick, Mark last_name: Kirkpatrick - first_name: Toby full_name: Johnson, Toby last_name: Johnson - first_name: Nicholas H full_name: Barton, Nicholas H id: 4880FE40-F248-11E8-B48F-1D18A9856A87 last_name: Barton orcid: 0000-0002-8548-5240 citation: ama: Kirkpatrick M, Johnson T, Barton NH. General models of multilocus evolution. Genetics. 2002;161(4):1727-1750. doi:10.1093/genetics/161.4.1727 apa: Kirkpatrick, M., Johnson, T., & Barton, N. H. (2002). General models of multilocus evolution. Genetics. Genetics Society of America. https://doi.org/10.1093/genetics/161.4.1727 chicago: Kirkpatrick, Mark, Toby Johnson, and Nicholas H Barton. “General Models of Multilocus Evolution.” Genetics. Genetics Society of America, 2002. https://doi.org/10.1093/genetics/161.4.1727. ieee: M. Kirkpatrick, T. Johnson, and N. H. Barton, “General models of multilocus evolution,” Genetics, vol. 161, no. 4. Genetics Society of America, pp. 1727–1750, 2002. ista: Kirkpatrick M, Johnson T, Barton NH. 2002. General models of multilocus evolution. Genetics. 161(4), 1727–1750. mla: Kirkpatrick, Mark, et al. “General Models of Multilocus Evolution.” Genetics, vol. 161, no. 4, Genetics Society of America, 2002, pp. 1727–50, doi:10.1093/genetics/161.4.1727. short: M. Kirkpatrick, T. Johnson, N.H. Barton, Genetics 161 (2002) 1727–1750. date_created: 2018-12-11T12:04:17Z date_published: 2002-08-01T00:00:00Z date_updated: 2023-07-11T13:20:26Z day: '01' doi: 10.1093/genetics/161.4.1727 extern: '1' external_id: pmid: - '12196414' intvolume: ' 161' issue: '4' language: - iso: eng main_file_link: - open_access: '1' url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1462196/ month: '08' oa: 1 oa_version: Published Version page: 1727 - 1750 pmid: 1 publication: Genetics publication_identifier: issn: - 0016-6731 publication_status: published publisher: Genetics Society of America publist_id: '2762' quality_controlled: '1' scopus_import: '1' status: public title: General models of multilocus evolution type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 161 year: '2002' ... --- _id: '3757' abstract: - lang: eng text: A central problem in biology is determining how genes interact as parts of functional networks. Creation and analysis of synthetic networks, composed of well-characterized genetic elements, provide a framework for theoretical modeling. Here, with the use of a combinatorial method, a library of networks with varying connectivity was generated in Escherichia coli. These networks were composed of genes encoding the transcriptional regulators Lacl, TetR, and lambda Cl, as well as the corresponding promoters. They displayed phenotypic behaviors resembling binary logical circuits, with two chemical “inputs” and a fluorescent protein “output.” Within this simple system, diverse computational functions arose through changes in network connectivity. Combinatorial synthesis provides an alternative approach for studying biological networks, as well as an efficient method for producing diverse phenotypes in vivo. article_processing_charge: No article_type: original author: - first_name: Calin C full_name: Guet, Calin C id: 47F8433E-F248-11E8-B48F-1D18A9856A87 last_name: Guet orcid: 0000-0001-6220-2052 - first_name: Michael full_name: Elowitz, Michael last_name: Elowitz - first_name: Weihong full_name: Hsing, Weihong last_name: Hsing - first_name: Stanislas full_name: Leibler, Stanislas last_name: Leibler citation: ama: Guet CC, Elowitz M, Hsing W, Leibler S. Combinatorial synthesis of genetic networks. Science. 2002;296(5572):1466-1470. doi:10.1126/science.1067407 apa: Guet, C. C., Elowitz, M., Hsing, W., & Leibler, S. (2002). Combinatorial synthesis of genetic networks. Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.1067407 chicago: Guet, Calin C, Michael Elowitz, Weihong Hsing, and Stanislas Leibler. “Combinatorial Synthesis of Genetic Networks.” Science. American Association for the Advancement of Science, 2002. https://doi.org/10.1126/science.1067407. ieee: C. C. Guet, M. Elowitz, W. Hsing, and S. Leibler, “Combinatorial synthesis of genetic networks,” Science, vol. 296, no. 5572. American Association for the Advancement of Science, pp. 1466–1470, 2002. ista: Guet CC, Elowitz M, Hsing W, Leibler S. 2002. Combinatorial synthesis of genetic networks. Science. 296(5572), 1466–1470. mla: Guet, Calin C., et al. “Combinatorial Synthesis of Genetic Networks.” Science, vol. 296, no. 5572, American Association for the Advancement of Science, 2002, pp. 1466–70, doi:10.1126/science.1067407. short: C.C. Guet, M. Elowitz, W. Hsing, S. Leibler, Science 296 (2002) 1466–1470. date_created: 2018-12-11T12:05:00Z date_published: 2002-05-24T00:00:00Z date_updated: 2023-07-11T12:48:53Z day: '24' doi: 10.1126/science.1067407 extern: '1' external_id: pmid: - '12029133' intvolume: ' 296' issue: '5572' language: - iso: eng month: '05' oa_version: None page: 1466 - 1470 pmid: 1 publication: Science publication_identifier: issn: - 0036-8075 publication_status: published publisher: American Association for the Advancement of Science publist_id: '2471' quality_controlled: '1' scopus_import: '1' status: public title: Combinatorial synthesis of genetic networks type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 296 year: '2002' ... --- _id: '3497' abstract: - lang: eng text: The use of advanced patch-clamp recording techniques in brain slices, such as simultaneous recording from multiple neurons and recording from dendrites or presynaptic terminals, demands slices of the highest quality. In this context the mechanics of the tissue slicer are an important factor. Ideally, a tissue slicer should generate large-amplitude and high-frequency movements of the cutting blade in a horizontal axis, with minimal vibrations in the vertical axis. We developed a vibroslicer that fulfils these in part conflicting requirements. The oscillator is a permanent-magnet-coil-leaf-spring system. Using an auto-resonant mechano-electrical feedback circuit, large horizontal oscillations (up to 3 mm peak-to-peak) with high frequency (,90 Hz) are generated. To minimize vertical vibrations, an adjustment mechanism was employed that allowed alignment of the cutting edge of the blade with the major axis of the oscillation. A vibroprobe device was used to monitor vertical vibrations during adjustment. The system is based on the shading of the light path between a light-emitting diode (LED) and a photodiode. Vibroprobe monitoring revealed that the vibroslicer, after appropriate adjustment, generated vertical vibrations of <1 µm, significantly less than many commercial tissue slicers. Light- and electron-microscopic analysis of surface layers of slices cut with the vibroslicer showed that cellular elements, dendritic processes and presynaptic terminals are well preserved under these conditions, as required for patch-clamp recording from these structures. acknowledgement: "We thank Dr. M. Frotscher for reading the manuscript, and H. Kressner, R. Laufersweiler, and A. Bühler for help with the construction of several prototypes of vibroslicer and vibroprobe. We also thank A. Blomenkamp, K. Winterhalter, B. Joch, and A. Schneider for technical assistance. This work was supported by grants of the Deutsche Forschungsgemeinschaft\r\n(SFB 505/C5, C6) and the Human Frontiers Science Program Organization (RG0017/1998-B)." article_processing_charge: No article_type: original author: - first_name: Jörg full_name: Geiger, Jörg last_name: Geiger - first_name: Joseph full_name: Bischofberger, Joseph last_name: Bischofberger - first_name: Imre full_name: Vida, Imre last_name: Vida - first_name: Ulrich full_name: Fröbe, Ulrich last_name: Fröbe - first_name: S full_name: Pfitzinger, S last_name: Pfitzinger - first_name: H. full_name: Weber, H. last_name: Weber - first_name: Klaus full_name: Haverkampf, Klaus last_name: Haverkampf - first_name: Peter M full_name: Jonas, Peter M id: 353C1B58-F248-11E8-B48F-1D18A9856A87 last_name: Jonas orcid: 0000-0001-5001-4804 citation: ama: 'Geiger J, Bischofberger J, Vida I, et al. Patch-clamp recording in brain slices with improved slicer technology. Pflugers Archiv : European Journal of Physiology. 2002;443(3):491-501. doi:10.1007/s00424-001-0735-3' apa: 'Geiger, J., Bischofberger, J., Vida, I., Fröbe, U., Pfitzinger, S., Weber, H., … Jonas, P. M. (2002). Patch-clamp recording in brain slices with improved slicer technology. Pflugers Archiv : European Journal of Physiology. Springer. https://doi.org/10.1007/s00424-001-0735-3' chicago: 'Geiger, Jörg, Joseph Bischofberger, Imre Vida, Ulrich Fröbe, S Pfitzinger, H. Weber, Klaus Haverkampf, and Peter M Jonas. “Patch-Clamp Recording in Brain Slices with Improved Slicer Technology.” Pflugers Archiv : European Journal of Physiology. Springer, 2002. https://doi.org/10.1007/s00424-001-0735-3.' ieee: 'J. Geiger et al., “Patch-clamp recording in brain slices with improved slicer technology,” Pflugers Archiv : European Journal of Physiology, vol. 443, no. 3. Springer, pp. 491–501, 2002.' ista: 'Geiger J, Bischofberger J, Vida I, Fröbe U, Pfitzinger S, Weber H, Haverkampf K, Jonas PM. 2002. Patch-clamp recording in brain slices with improved slicer technology. Pflugers Archiv : European Journal of Physiology. 443(3), 491–501.' mla: 'Geiger, Jörg, et al. “Patch-Clamp Recording in Brain Slices with Improved Slicer Technology.” Pflugers Archiv : European Journal of Physiology, vol. 443, no. 3, Springer, 2002, pp. 491–501, doi:10.1007/s00424-001-0735-3.' short: 'J. Geiger, J. Bischofberger, I. Vida, U. Fröbe, S. Pfitzinger, H. Weber, K. Haverkampf, P.M. Jonas, Pflugers Archiv : European Journal of Physiology 443 (2002) 491–501.' date_created: 2018-12-11T12:03:38Z date_published: 2002-01-01T00:00:00Z date_updated: 2023-07-17T07:36:37Z day: '01' doi: 10.1007/s00424-001-0735-3 extern: '1' external_id: pmid: - '11810221' intvolume: ' 443' issue: '3' language: - iso: eng month: '01' oa_version: None page: 491 - 501 pmid: 1 publication: 'Pflugers Archiv : European Journal of Physiology' publication_identifier: issn: - 0031-6768 publication_status: published publisher: Springer publist_id: '2890' quality_controlled: '1' scopus_import: '1' status: public title: Patch-clamp recording in brain slices with improved slicer technology type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 443 year: '2002' ... --- _id: '3533' abstract: - lang: eng text: 'Information in neuronal networks is thought to be represented by the rate of discharge and the temporal relationship between the discharging neurons. The discharge frequency of neurons is affected by their afferents and intrinsic properties, and shows great individual variability. The temporal coordination of neurons is greatly facilitated by network oscillations. In the hippocampus, population synchrony fluctuates during theta and gamma oscillations (10-100 ms scale) and can increase almost 10-fold during sharp wave bursts. Despite these large changes in excitability in the sub-second scale, longer-term (minute-scale) firing rates of individual neurons are relatively constant in an unchanging environment. As a result, mean hippocampal output remains stable over time. To understand the mechanisms responsible for this homeostasis, we address the following issues: (i) Can firing rates of single cells be modified? (ii) Once modified, what mechanism(s) can maintain the changes? We show that firing rates of hippocampal pyramidal cells can be altered in a novel environment and by Hebbian pairing of physiological input patterns with postsynaptic burst discharge. We also illustrate a competition between single spikes and the occurrence of spike bursts. Since spike-inducing (suprathreshold) inputs decrease the ability of strong (''teaching'') inputs to induce a burst discharge, we propose that the single spike versus burst competition presents a homeostatic regulatory mechanism to maintain synaptic strength and, consequently, firing rate in pyramidal cells.' article_processing_charge: No article_type: original author: - first_name: György full_name: Buzsáki, György last_name: Buzsáki - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 - first_name: George full_name: Dragoi, George last_name: Dragoi - first_name: Kenneth full_name: Harris, Kenneth last_name: Harris - first_name: D. full_name: Henze, D. last_name: Henze - first_name: Hajima full_name: Hirase, Hajima last_name: Hirase citation: ama: Buzsáki G, Csicsvari JL, Dragoi G, Harris K, Henze D, Hirase H. Homeostatic maintenance of neuronal excitability by burst discharges in vivo. Cerebral Cortex. 2002;12(9):893-899. doi:10.1093/cercor/12.9.893 apa: Buzsáki, G., Csicsvari, J. L., Dragoi, G., Harris, K., Henze, D., & Hirase, H. (2002). Homeostatic maintenance of neuronal excitability by burst discharges in vivo. Cerebral Cortex. Oxford University Press. https://doi.org/10.1093/cercor/12.9.893 chicago: Buzsáki, György, Jozsef L Csicsvari, George Dragoi, Kenneth Harris, D. Henze, and Hajima Hirase. “Homeostatic Maintenance of Neuronal Excitability by Burst Discharges in Vivo.” Cerebral Cortex. Oxford University Press, 2002. https://doi.org/10.1093/cercor/12.9.893. ieee: G. Buzsáki, J. L. Csicsvari, G. Dragoi, K. Harris, D. Henze, and H. Hirase, “Homeostatic maintenance of neuronal excitability by burst discharges in vivo,” Cerebral Cortex, vol. 12, no. 9. Oxford University Press, pp. 893–899, 2002. ista: Buzsáki G, Csicsvari JL, Dragoi G, Harris K, Henze D, Hirase H. 2002. Homeostatic maintenance of neuronal excitability by burst discharges in vivo. Cerebral Cortex. 12(9), 893–899. mla: Buzsáki, György, et al. “Homeostatic Maintenance of Neuronal Excitability by Burst Discharges in Vivo.” Cerebral Cortex, vol. 12, no. 9, Oxford University Press, 2002, pp. 893–99, doi:10.1093/cercor/12.9.893. short: G. Buzsáki, J.L. Csicsvari, G. Dragoi, K. Harris, D. Henze, H. Hirase, Cerebral Cortex 12 (2002) 893–899. date_created: 2018-12-11T12:03:50Z date_published: 2002-09-01T00:00:00Z date_updated: 2023-07-17T07:27:12Z day: '01' doi: 10.1093/cercor/12.9.893 extern: '1' external_id: pmid: - '12183388' intvolume: ' 12' issue: '9' language: - iso: eng month: '09' oa_version: None page: 893 - 899 pmid: 1 publication: Cerebral Cortex publication_identifier: issn: - 1047-3211 publication_status: published publisher: Oxford University Press publist_id: '2851' quality_controlled: '1' scopus_import: '1' status: public title: Homeostatic maintenance of neuronal excitability by burst discharges in vivo type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 12 year: '2002' ... --- _id: '3424' abstract: - lang: eng text: "We give a brief overview of the current understanding of the explosion mechanism of core collapse supernovae. Our main focus is the impact of rotation on the explosion. Recent observations of the polarization of the light emitted by supernova explosions indicate that there are large deviations from spherical symmetry in the very heart of the explosion the origin of which is unknown. We use the new approach of a three dimensional test particle based simulation to simulate the infall phase of a supernova event. The underlying microphysics is simplified to make this computationally possible. A systematic study of the influence of rotation mainly during the infall phase of the collapse of a typical iron core is performed. Indications for significant deviations from spherical symmetry are found in our very rapidly rotating models. © 2002 American Institute of Physics\r\n" alternative_title: - Exotic Clustering, American Institute of Physics Conference Proceedings article_processing_charge: No author: - first_name: Mark Tobias full_name: Bollenbach, Mark Tobias id: 3E6DB97A-F248-11E8-B48F-1D18A9856A87 last_name: Bollenbach orcid: 0000-0003-4398-476X - first_name: Wolfgang full_name: Bauer, Wolfgang last_name: Bauer citation: ama: 'Bollenbach MT, Bauer W. 3d supernovae collapse calculations. In: Vol 644. American Institute of Physics; 2002:219-232. doi:10.1063/1.1523196 ' apa: 'Bollenbach, M. T., & Bauer, W. (2002). 3d supernovae collapse calculations (Vol. 644, pp. 219–232). Presented at the CRIS: Catania Relativistic Ion Studies , Catania, Italy: American Institute of Physics. https://doi.org/10.1063/1.1523196 ' chicago: Bollenbach, Mark Tobias, and Wolfgang Bauer. “3d Supernovae Collapse Calculations,” 644:219–32. American Institute of Physics, 2002. https://doi.org/10.1063/1.1523196 . ieee: 'M. T. Bollenbach and W. Bauer, “3d supernovae collapse calculations,” presented at the CRIS: Catania Relativistic Ion Studies , Catania, Italy, 2002, vol. 644, pp. 219–232.' ista: 'Bollenbach MT, Bauer W. 2002. 3d supernovae collapse calculations. CRIS: Catania Relativistic Ion Studies , Exotic Clustering, American Institute of Physics Conference Proceedings, vol. 644, 219–232.' mla: Bollenbach, Mark Tobias, and Wolfgang Bauer. 3d Supernovae Collapse Calculations. Vol. 644, American Institute of Physics, 2002, pp. 219–32, doi:10.1063/1.1523196 . short: M.T. Bollenbach, W. Bauer, in:, American Institute of Physics, 2002, pp. 219–232. conference: end_date: 2002-06-14 location: Catania, Italy name: 'CRIS: Catania Relativistic Ion Studies ' start_date: 2002-06-10 date_created: 2018-12-11T12:03:15Z date_published: 2002-11-26T00:00:00Z date_updated: 2023-07-17T11:05:27Z day: '26' doi: '10.1063/1.1523196 ' extern: '1' intvolume: ' 644' language: - iso: eng month: '11' oa_version: None page: 219 - 232 publication_identifier: isbn: - '9781510832008' publication_status: published publisher: American Institute of Physics publist_id: '2977' quality_controlled: '1' status: public title: 3d supernovae collapse calculations type: conference user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 644 year: '2002' ... --- _id: '2988' abstract: - lang: eng text: Coordination of cell and tissue polarity commonly involves directional signaling [1]. In the Arabidopsis root epidermis, cell polarity is revealed by basal, root tip-oriented, hair outgrowth from hair-forming cells (trichoblasts) [2]. The plant hormone auxin displays polar movements [1, 3] and accumulates at maximum concentration in the root tip [4, 5]. The application of polar auxin transport inhibitors [3] evokes changes in trichoblast polarity only at high concentrations and after long-term application [2, 4]. Thus, it remains open whether components of the auxin transport machinery mediate establishment of trichoblast polarity. Here we report that the presumptive auxin influx carrier AUX1 [6, 7] contributes to apical-basal hair cell polarity. AUX1 function is required for polarity changes induced by exogenous application of the auxin 2,4-D, a preferential influx carrier substrate. Similar to aux1 mutants, the vesicle trafficking inhibitor brefeldin A (BFA) interferes with polar hair initiation, and AUX1 function is required for BFA-mediated polarity changes. Consistently, BFA inhibits membrane trafficking of AUX1, trichoblast hyperpolarization induced by 2,4-D, and alters the distal auxin maximum. Our results identify AUX1 as one component of a novel BFA-sensitive auxin transport pathway polarizing cells toward a hormone maximum. article_processing_charge: No article_type: original author: - first_name: Markus full_name: Grebe, Markus last_name: Grebe - first_name: Jirí full_name: Friml, Jirí id: 4159519E-F248-11E8-B48F-1D18A9856A87 last_name: Friml orcid: 0000-0002-8302-7596 - first_name: Ranjan full_name: Swarup, Ranjan last_name: Swarup - first_name: Karin full_name: Ljung, Karin last_name: Ljung - first_name: Göran full_name: Sandberg, Göran last_name: Sandberg - first_name: Maarten full_name: Terlou, Maarten last_name: Terlou - first_name: Klaus full_name: Palme, Klaus last_name: Palme - first_name: Malcolm full_name: Bennett, Malcolm last_name: Bennett - first_name: Ben full_name: Scheres, Ben last_name: Scheres citation: ama: Grebe M, Friml J, Swarup R, et al. Cell polarity signaling in Arabidopsis involves a BFA sensitive auxin influx pathway. Current Biology. 2002;12(4):329-334. doi:10.1016/S0960-9822(02)00654-1 apa: Grebe, M., Friml, J., Swarup, R., Ljung, K., Sandberg, G., Terlou, M., … Scheres, B. (2002). Cell polarity signaling in Arabidopsis involves a BFA sensitive auxin influx pathway. Current Biology. Cell Press. https://doi.org/10.1016/S0960-9822(02)00654-1 chicago: Grebe, Markus, Jiří Friml, Ranjan Swarup, Karin Ljung, Göran Sandberg, Maarten Terlou, Klaus Palme, Malcolm Bennett, and Ben Scheres. “Cell Polarity Signaling in Arabidopsis Involves a BFA Sensitive Auxin Influx Pathway.” Current Biology. Cell Press, 2002. https://doi.org/10.1016/S0960-9822(02)00654-1. ieee: M. Grebe et al., “Cell polarity signaling in Arabidopsis involves a BFA sensitive auxin influx pathway,” Current Biology, vol. 12, no. 4. Cell Press, pp. 329–334, 2002. ista: Grebe M, Friml J, Swarup R, Ljung K, Sandberg G, Terlou M, Palme K, Bennett M, Scheres B. 2002. Cell polarity signaling in Arabidopsis involves a BFA sensitive auxin influx pathway. Current Biology. 12(4), 329–334. mla: Grebe, Markus, et al. “Cell Polarity Signaling in Arabidopsis Involves a BFA Sensitive Auxin Influx Pathway.” Current Biology, vol. 12, no. 4, Cell Press, 2002, pp. 329–34, doi:10.1016/S0960-9822(02)00654-1. short: M. Grebe, J. Friml, R. Swarup, K. Ljung, G. Sandberg, M. Terlou, K. Palme, M. Bennett, B. Scheres, Current Biology 12 (2002) 329–334. date_created: 2018-12-11T12:00:43Z date_published: 2002-02-19T00:00:00Z date_updated: 2023-07-17T12:15:28Z day: '19' doi: 10.1016/S0960-9822(02)00654-1 extern: '1' external_id: pmid: - '11864575' intvolume: ' 12' issue: '4' language: - iso: eng month: '02' oa_version: None page: 329 - 334 pmid: 1 publication: Current Biology publication_identifier: issn: - 0960-9822 publication_status: published publisher: Cell Press publist_id: '3714' quality_controlled: '1' scopus_import: '1' status: public title: Cell polarity signaling in Arabidopsis involves a BFA sensitive auxin influx pathway type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 12 year: '2002' ... --- _id: '3421' abstract: - lang: eng text: Single molecule experiments provide insight into the individuality of biological macromolecules, their unique function, reaction pathways, trajectories and molecular interactions. The exceptional signal-to-noise ratio of the atomic force microscope allows individual proteins to be imaged under physiologically relevant conditions at a lateral resolution of 0.5–1 nm and a vertical resolution of 0.1–0.2 nm. Recently, it has become possible to observe single molecule events using this technique. This capability is reviewed on various water-soluble and membrane proteins. Examples of the observation of function, variability, and assembly of single proteins are discussed. Statistical analysis is important to extend conclusions derived from single molecule experiments to protein species. Such approaches allow the classification of protein conformations and movements. Recent developments of probe microscopy techniques allow simultaneous measurement of multiple signals on individual macromolecules, and greatly extend the range of experiments possible for probing biological systems at the molecular level. Biologists exploring molecular mechanisms will benefit from a burgeoning of scanning probe microscopes and of their future combination with molecular biological experiments. article_processing_charge: No article_type: review author: - first_name: Daniel full_name: Mueller, Daniel last_name: Mueller - first_name: Harald L full_name: Janovjak, Harald L id: 33BA6C30-F248-11E8-B48F-1D18A9856A87 last_name: Janovjak orcid: 0000-0002-8023-9315 - first_name: Tiina full_name: Lehto, Tiina last_name: Lehto - first_name: Lars full_name: Kuerschner, Lars last_name: Kuerschner - first_name: Kurt full_name: Anderson, Kurt last_name: Anderson citation: ama: Mueller D, Janovjak HL, Lehto T, Kuerschner L, Anderson K. Observing structure, function and assembly of single proteins by AFM. Progress in Biophysics and Molecular Biology. 2002;79(1-3):1-43. doi:10.1016/S0079-6107(02)00009-3 apa: Mueller, D., Janovjak, H. L., Lehto, T., Kuerschner, L., & Anderson, K. (2002). Observing structure, function and assembly of single proteins by AFM. Progress in Biophysics and Molecular Biology. Elsevier. https://doi.org/10.1016/S0079-6107(02)00009-3 chicago: Mueller, Daniel, Harald L Janovjak, Tiina Lehto, Lars Kuerschner, and Kurt Anderson. “Observing Structure, Function and Assembly of Single Proteins by AFM.” Progress in Biophysics and Molecular Biology. Elsevier, 2002. https://doi.org/10.1016/S0079-6107(02)00009-3. ieee: D. Mueller, H. L. Janovjak, T. Lehto, L. Kuerschner, and K. Anderson, “Observing structure, function and assembly of single proteins by AFM,” Progress in Biophysics and Molecular Biology, vol. 79, no. 1–3. Elsevier, pp. 1–43, 2002. ista: Mueller D, Janovjak HL, Lehto T, Kuerschner L, Anderson K. 2002. Observing structure, function and assembly of single proteins by AFM. Progress in Biophysics and Molecular Biology. 79(1–3), 1–43. mla: Mueller, Daniel, et al. “Observing Structure, Function and Assembly of Single Proteins by AFM.” Progress in Biophysics and Molecular Biology, vol. 79, no. 1–3, Elsevier, 2002, pp. 1–43, doi:10.1016/S0079-6107(02)00009-3. short: D. Mueller, H.L. Janovjak, T. Lehto, L. Kuerschner, K. Anderson, Progress in Biophysics and Molecular Biology 79 (2002) 1–43. date_created: 2018-12-11T12:03:14Z date_published: 2002-05-01T00:00:00Z date_updated: 2023-07-17T11:36:32Z day: '01' doi: 10.1016/S0079-6107(02)00009-3 extern: '1' external_id: pmid: - '12225775' intvolume: ' 79' issue: 1-3 language: - iso: eng month: '05' oa_version: None page: 1 - 43 pmid: 1 publication: Progress in Biophysics and Molecular Biology publication_identifier: issn: - 0079-6107 publication_status: published publisher: Elsevier publist_id: '2980' quality_controlled: '1' scopus_import: '1' status: public title: Observing structure, function and assembly of single proteins by AFM type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 79 year: '2002' ... --- _id: '2989' abstract: - lang: eng text: In contrast to animals, little is known about pattern formation in plants. Physiological and genetic data suggest the involvement of the phytohormone auxin in this process. Here, we characterize a novel member of the PIN family of putative auxin efflux carriers, Arabidopsis PIN4, that is localized in developing and mature root meristems. Atpin4 mutants are defective in establishment and maintenance of endogenous auxin gradients, fail to canalize externally applied auxin, and display various patterning defects in both embryonic and seedling roots. We propose a role for AtPIN4 in generating a sink for auxin below the quiescent center of the root meristem that is essential for auxin distribution and patterning. acknowledgement: We thank Petra Tänzler, Michaela Lehnen, and Thomas Steinmann for technical help. We acknowledge the Arabidopsis Biological Resource Center (Columbus, OH) and Thomas Altman for providing material. We also gratefully acknowledge the ADIS service group for DNA sequencing and ZIGIA (Center for Functional Genomics in Arabidopsis) for the En lines. We are grateful to our colleagues, particularly Leo Gälweiler, Niko Geldner, Matthias Godde, and Kathrin Schrick for critical reading of the manuscript. This work was supported by a fellowship of the Deutscher Akademischer Austauschdienset (J.F.), the Deutsche Forschungsgemeinschaft (Schwerpunktprogramm Phytohormone), the European Communities Biotechnology Programs, the Fonds der Chemischen Industrie, and the INCO-Copernicus Program. article_processing_charge: No article_type: original author: - first_name: Jirí full_name: Friml, Jirí id: 4159519E-F248-11E8-B48F-1D18A9856A87 last_name: Friml orcid: 0000-0002-8302-7596 - first_name: Eva full_name: Benková, Eva id: 38F4F166-F248-11E8-B48F-1D18A9856A87 last_name: Benková orcid: 0000-0002-8510-9739 - first_name: Ikram full_name: Blilou, Ikram last_name: Blilou - first_name: Justyna full_name: Wiśniewska, Justyna last_name: Wiśniewska - first_name: Thorsten full_name: Hamann, Thorsten last_name: Hamann - first_name: Karin full_name: Ljung, Karin last_name: Ljung - first_name: Scott full_name: Woody, Scott last_name: Woody - first_name: Göran full_name: Sandberg, Göran last_name: Sandberg - first_name: Ben full_name: Scheres, Ben last_name: Scheres - first_name: Gerd full_name: Jürgens, Gerd last_name: Jürgens - first_name: Klaus full_name: Palme, Klaus last_name: Palme citation: ama: Friml J, Benková E, Blilou I, et al. AtPIN4 mediates sink-driven auxin gradients and root patterning in Arabidopsis. Cell. 2002;108(5):661-673. doi:10.1016/S0092-8674(02)00656-6 apa: Friml, J., Benková, E., Blilou, I., Wiśniewska, J., Hamann, T., Ljung, K., … Palme, K. (2002). AtPIN4 mediates sink-driven auxin gradients and root patterning in Arabidopsis. Cell. Cell Press. https://doi.org/10.1016/S0092-8674(02)00656-6 chicago: Friml, Jiří, Eva Benková, Ikram Blilou, Justyna Wiśniewska, Thorsten Hamann, Karin Ljung, Scott Woody, et al. “AtPIN4 Mediates Sink-Driven Auxin Gradients and Root Patterning in Arabidopsis.” Cell. Cell Press, 2002. https://doi.org/10.1016/S0092-8674(02)00656-6. ieee: J. Friml et al., “AtPIN4 mediates sink-driven auxin gradients and root patterning in Arabidopsis,” Cell, vol. 108, no. 5. Cell Press, pp. 661–673, 2002. ista: Friml J, Benková E, Blilou I, Wiśniewska J, Hamann T, Ljung K, Woody S, Sandberg G, Scheres B, Jürgens G, Palme K. 2002. AtPIN4 mediates sink-driven auxin gradients and root patterning in Arabidopsis. Cell. 108(5), 661–673. mla: Friml, Jiří, et al. “AtPIN4 Mediates Sink-Driven Auxin Gradients and Root Patterning in Arabidopsis.” Cell, vol. 108, no. 5, Cell Press, 2002, pp. 661–73, doi:10.1016/S0092-8674(02)00656-6. short: J. Friml, E. Benková, I. Blilou, J. Wiśniewska, T. Hamann, K. Ljung, S. Woody, G. Sandberg, B. Scheres, G. Jürgens, K. Palme, Cell 108 (2002) 661–673. date_created: 2018-12-11T12:00:43Z date_published: 2002-03-08T00:00:00Z date_updated: 2023-07-17T11:57:40Z day: '08' doi: 10.1016/S0092-8674(02)00656-6 extern: '1' external_id: pmid: - '11893337' intvolume: ' 108' issue: '5' language: - iso: eng month: '03' oa_version: None page: 661 - 673 pmid: 1 publication: Cell publication_identifier: issn: - 0092-8674 publication_status: published publisher: Cell Press publist_id: '3713' quality_controlled: '1' scopus_import: '1' status: public title: AtPIN4 mediates sink-driven auxin gradients and root patterning in Arabidopsis type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 108 year: '2002' ... --- _id: '3422' abstract: - lang: eng text: Quantitative real-time PCR represents a highly sensitive and powerful technique for the quantitation of nucleic acids. It has a tremendous potential for the high-throughput analysis of gene expression in research and routine diagnostics. However, the major hurdle is not the practical performance of the experiments themselves but rather the efficient evaluation and the mathematical and statistical analysis of the enormous amount of data gained by this technology, as these functions are not included in the software provided by the manufacturers of the detection systems. In this work, we focus on the mathematical evaluation and analysis of the data generated by quantitative real-time PCR, the calculation of the final results, the propagation of experimental variation of the measured values to the final results, and the statistical analysis. We developed a Microsoft Excel-based software application coded in Visual Basic for Applications, called Q-Gene, which addresses these points. Q-Gene manages and expedites the planning, performance, and evaluation of quantitative real-time PCR experiments, as well as the mathematical and statistical analysis, storage, and graphical presentation of the data. The Q-Gene software application is a tool to cope with complex quantitative real-time PCR experiments at a high-throughput scale and considerably expedites and rationalizes the experimental setup, data analysis, and data management while ensuring highest reproducibility. article_processing_charge: No article_type: original author: - first_name: Patrick full_name: Müller, Patrick last_name: Müller - first_name: Harald L full_name: Janovjak, Harald L id: 33BA6C30-F248-11E8-B48F-1D18A9856A87 last_name: Janovjak orcid: 0000-0002-8023-9315 - first_name: Andre full_name: Miserez, Andre last_name: Miserez - first_name: Zuzana full_name: Dobbie, Zuzana last_name: Dobbie citation: ama: Müller P, Janovjak HL, Miserez A, Dobbie Z. Processing of gene expression data generated by quantitative real-time RT-PCR. Biotechniques. 2002;32(6):1372-1379. apa: Müller, P., Janovjak, H. L., Miserez, A., & Dobbie, Z. (2002). Processing of gene expression data generated by quantitative real-time RT-PCR. Biotechniques. Informa Healthcare. chicago: Müller, Patrick, Harald L Janovjak, Andre Miserez, and Zuzana Dobbie. “Processing of Gene Expression Data Generated by Quantitative Real-Time RT-PCR.” Biotechniques. Informa Healthcare, 2002. ieee: P. Müller, H. L. Janovjak, A. Miserez, and Z. Dobbie, “Processing of gene expression data generated by quantitative real-time RT-PCR,” Biotechniques, vol. 32, no. 6. Informa Healthcare, pp. 1372–1379, 2002. ista: Müller P, Janovjak HL, Miserez A, Dobbie Z. 2002. Processing of gene expression data generated by quantitative real-time RT-PCR. Biotechniques. 32(6), 1372–1379. mla: Müller, Patrick, et al. “Processing of Gene Expression Data Generated by Quantitative Real-Time RT-PCR.” Biotechniques, vol. 32, no. 6, Informa Healthcare, 2002, pp. 1372–79. short: P. Müller, H.L. Janovjak, A. Miserez, Z. Dobbie, Biotechniques 32 (2002) 1372–1379. date_created: 2018-12-11T12:03:15Z date_published: 2002-06-01T00:00:00Z date_updated: 2023-07-17T11:29:06Z day: '01' extern: '1' external_id: pmid: - '12074169' intvolume: ' 32' issue: '6' language: - iso: eng month: '06' oa_version: None page: 1372 - 1379 pmid: 1 publication: Biotechniques publication_identifier: issn: - 0736-6205 publication_status: published publisher: Informa Healthcare publist_id: '2979' quality_controlled: '1' scopus_import: '1' status: public title: Processing of gene expression data generated by quantitative real-time RT-PCR type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 32 year: '2002' ... --- _id: '3140' abstract: - lang: eng text: The maturation of synaptic structures depends on inductive interactions between axons and their prospective targets. One example of such an interaction is the influence of proprioceptive sensory axons on the differentiation of muscle spindles. We have monitored the expression of three transcription factors, Egr3, Pea3, and Erm, that delineate early muscle spindle development in an assay of muscle spindle-inducing signals. We provide genetic evidence that Neuregulin1 (Nrg1) is required for proprioceptive afferent-evoked induction of muscle spindle differentiation in the mouse. Ig-Nrg1 isoforms are preferentially expressed by proprioceptive sensory neurons and are sufficient to induce muscle spindle differentiation in vivo, whereas CRD-Nrg1 isoforms are broadly expressed in sensory and motor neurons but are not required for muscle spindle induction. acknowledgement: We thank L. Role for generously providing the CRD-Nrg1 mutant allele for these studies, L. Parada and D. Anderson for sharing the TrkC and Ngn1 mouse strains, W. Tourtellotte for providing Egr3 mutant mice, E. Avetisova for expert technical assistance, X. Yang for experimental help in the initial phase of these studies, A. Garratt for advice with ErbB antibodies, and L. Role and G. Fischbach for helpful discussions. The CRD-Nrg1 mutant allele was generated in the lab of Dr. Lorna Role, with the support of NIH grant NS29071. S.A. and S.H. were supported by a grant from the Swiss National Science Foundation and the Kanton of Basel-Stadt. S.J.B. was supported by grants from the NINDS. N.A.S. was supported by a Howard Hughes Medical Institute Postdoctoral Fellowship for Physicians and a Career Development Award from the NINDS. T.M.J. was supported by grants from NINDS and is an Investigator of the Howard Hughes Medical Institute. article_processing_charge: No article_type: original author: - first_name: Simon full_name: Hippenmeyer, Simon id: 37B36620-F248-11E8-B48F-1D18A9856A87 last_name: Hippenmeyer orcid: 0000-0003-2279-1061 - first_name: Neil full_name: Shneider, Neil last_name: Shneider - first_name: Carmen full_name: Birchmeier, Carmen last_name: Birchmeier - first_name: Steven full_name: Burden, Steven last_name: Burden - first_name: Thomas full_name: Jessell, Thomas last_name: Jessell - first_name: Silvia full_name: Arber, Silvia last_name: Arber citation: ama: Hippenmeyer S, Shneider N, Birchmeier C, Burden S, Jessell T, Arber S. A role for Neuregulin1 signaling in muscle spindle differentiation. Neuron. 2002;36(6):1035-1049. doi:10.1016/S0896-6273(02)01101-7 apa: Hippenmeyer, S., Shneider, N., Birchmeier, C., Burden, S., Jessell, T., & Arber, S. (2002). A role for Neuregulin1 signaling in muscle spindle differentiation. Neuron. Elsevier. https://doi.org/10.1016/S0896-6273(02)01101-7 chicago: Hippenmeyer, Simon, Neil Shneider, Carmen Birchmeier, Steven Burden, Thomas Jessell, and Silvia Arber. “A Role for Neuregulin1 Signaling in Muscle Spindle Differentiation.” Neuron. Elsevier, 2002. https://doi.org/10.1016/S0896-6273(02)01101-7. ieee: S. Hippenmeyer, N. Shneider, C. Birchmeier, S. Burden, T. Jessell, and S. Arber, “A role for Neuregulin1 signaling in muscle spindle differentiation,” Neuron, vol. 36, no. 6. Elsevier, pp. 1035–1049, 2002. ista: Hippenmeyer S, Shneider N, Birchmeier C, Burden S, Jessell T, Arber S. 2002. A role for Neuregulin1 signaling in muscle spindle differentiation. Neuron. 36(6), 1035–1049. mla: Hippenmeyer, Simon, et al. “A Role for Neuregulin1 Signaling in Muscle Spindle Differentiation.” Neuron, vol. 36, no. 6, Elsevier, 2002, pp. 1035–49, doi:10.1016/S0896-6273(02)01101-7. short: S. Hippenmeyer, N. Shneider, C. Birchmeier, S. Burden, T. Jessell, S. Arber, Neuron 36 (2002) 1035–1049. date_created: 2018-12-11T12:01:37Z date_published: 2002-12-19T00:00:00Z date_updated: 2023-07-17T11:46:43Z day: '19' doi: 10.1016/S0896-6273(02)01101-7 extern: '1' external_id: pmid: - '12495620' intvolume: ' 36' issue: '6' language: - iso: eng month: '12' oa_version: None page: 1035 - 1049 pmid: 1 publication: Neuron publication_identifier: issn: - 0896-6273 publication_status: published publisher: Elsevier publist_id: '3558' quality_controlled: '1' scopus_import: '1' status: public title: A role for Neuregulin1 signaling in muscle spindle differentiation type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 36 year: '2002' ... --- _id: '3423' article_processing_charge: No author: - first_name: Wolfgang full_name: Bauer, Wolfgang last_name: Bauer - first_name: Mark Tobias full_name: Bollenbach, Mark Tobias id: 3E6DB97A-F248-11E8-B48F-1D18A9856A87 last_name: Bollenbach orcid: 0000-0003-4398-476X - first_name: Marko full_name: Kleine Berkenbusch, Marko last_name: Kleine Berkenbusch - first_name: Holger full_name: Harreis, Holger last_name: Harreis citation: ama: 'Bauer W, Bollenbach MT, Kleine Berkenbusch M, Harreis H. The percolation interpretation of the nuclear fragmentation phase transition. In: Proceedings of the 18th Winter Workshop on Nuclear Dynamics. EP Systema; 2002:111-118.' apa: 'Bauer, W., Bollenbach, M. T., Kleine Berkenbusch, M., & Harreis, H. (2002). The percolation interpretation of the nuclear fragmentation phase transition. In Proceedings of the 18th Winter Workshop on Nuclear Dynamics (pp. 111–118). Nassau, Bahamas: EP Systema.' chicago: Bauer, Wolfgang, Mark Tobias Bollenbach, Marko Kleine Berkenbusch, and Holger Harreis. “The Percolation Interpretation of the Nuclear Fragmentation Phase Transition.” In Proceedings of the 18th Winter Workshop on Nuclear Dynamics, 111–18. EP Systema, 2002. ieee: W. Bauer, M. T. Bollenbach, M. Kleine Berkenbusch, and H. Harreis, “The percolation interpretation of the nuclear fragmentation phase transition,” in Proceedings of the 18th Winter Workshop on Nuclear Dynamics, Nassau, Bahamas, 2002, pp. 111–118. ista: Bauer W, Bollenbach MT, Kleine Berkenbusch M, Harreis H. 2002. The percolation interpretation of the nuclear fragmentation phase transition. Proceedings of the 18th Winter Workshop on Nuclear Dynamics. Winter Workshop on Nuclear Dynamics, 111–118. mla: Bauer, Wolfgang, et al. “The Percolation Interpretation of the Nuclear Fragmentation Phase Transition.” Proceedings of the 18th Winter Workshop on Nuclear Dynamics, EP Systema, 2002, pp. 111–18. short: W. Bauer, M.T. Bollenbach, M. Kleine Berkenbusch, H. Harreis, in:, Proceedings of the 18th Winter Workshop on Nuclear Dynamics, EP Systema, 2002, pp. 111–118. conference: end_date: 2002-01-22 location: Nassau, Bahamas name: Winter Workshop on Nuclear Dynamics start_date: 2002-01-20 date_created: 2018-12-11T12:03:15Z date_published: 2002-01-01T00:00:00Z date_updated: 2023-07-17T11:15:14Z day: '01' extern: '1' language: - iso: eng month: '01' oa_version: None page: 111 - 118 publication: Proceedings of the 18th Winter Workshop on Nuclear Dynamics publication_status: published publisher: EP Systema publist_id: '2978' status: public title: The percolation interpretation of the nuclear fragmentation phase transition type: conference user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 year: '2002' ... --- _id: '2986' abstract: - lang: eng text: Long-standing models propose that plant growth responses to light or gravity are mediated by asymmetric distribution of the phytohormone auxin. Physiological studies implicated a specific transport system that relocates auxin laterally, thereby effecting differential growth; however, neither the molecular components of this system nor the cellular mechanism of auxin redistribution on light or gravity perception have been identified. Here, we show that auxin accumulates asymmetrically during differential growth in an efflux-dependent manner. Mutations in the Arabidopsis gene PIN3, a regulator of auxin efflux, alter differential growth. PIN3 is expressed in gravity-sensing tissues, with PIN3 protein accumulating predominantly at the lateral cell surface. PIN3 localizes to the plasma membrane and to vesicles that cycle in an actin-dependent manner. In the root columella, PIN3 is positioned symmetrically at the plasma membrane but rapidly relocalizes laterally on gravity stimulation. Our data indicate that PIN3 is a component of the lateral auxin transport system regulating tropic growth. In addition, actin-dependent relocalization of PIN3 in response to gravity provides a mechanism for redirecting auxin flux to trigger asymmetric growth. acknowledgement: We thank G. Jürgens for enabling J.F. to accomplish part of this work in his laboratory; P. Tänzler and M. Sauer for technical assistance; H. Vahlenkamp for technical assistance in immunocytochemistry; M. Estelle for providing material and suggestions; T. Altman for BAC filter sets; the ADIS (Automated DNA Isolation and Sequencing) service group for DNA sequencing; ZIGIA (Center for Functional Genomics in Arabidopsis) for the En lines; and N. Geldner, T. Hamann, G. Jürgens, K. Schrick and C. Schwechheimer for comments and critical reading of the manuscript. This work was supported by a fellowship of the DAAD (J.F.), the DFG (Schwerpunktprogramm Phytohormone), the Fonds der chemischen Industrie, the European Communities Biotechnology Programs, the INCO-Copernicus Program and the European Space Agency MAP-Biotechnology Programme article_processing_charge: No article_type: original author: - first_name: Jirí full_name: Friml, Jirí id: 4159519E-F248-11E8-B48F-1D18A9856A87 last_name: Friml orcid: 0000-0002-8302-7596 - first_name: Justyna full_name: Wiśniewska, Justyna last_name: Wiśniewska - first_name: Eva full_name: Benková, Eva id: 38F4F166-F248-11E8-B48F-1D18A9856A87 last_name: Benková orcid: 0000-0002-8510-9739 - first_name: Kurt full_name: Mendgen, Kurt last_name: Mendgen - first_name: Klaus full_name: Palme, Klaus last_name: Palme citation: ama: Friml J, Wiśniewska J, Benková E, Mendgen K, Palme K. Lateral relocation of auxin efflux regulator PIN3 mediates tropism in Arabidopsis. Nature. 2002;415(6873):806-809. doi:10.1038/415806a apa: Friml, J., Wiśniewska, J., Benková, E., Mendgen, K., & Palme, K. (2002). Lateral relocation of auxin efflux regulator PIN3 mediates tropism in Arabidopsis. Nature. Nature Publishing Group. https://doi.org/10.1038/415806a chicago: Friml, Jiří, Justyna Wiśniewska, Eva Benková, Kurt Mendgen, and Klaus Palme. “Lateral Relocation of Auxin Efflux Regulator PIN3 Mediates Tropism in Arabidopsis.” Nature. Nature Publishing Group, 2002. https://doi.org/10.1038/415806a. ieee: J. Friml, J. Wiśniewska, E. Benková, K. Mendgen, and K. Palme, “Lateral relocation of auxin efflux regulator PIN3 mediates tropism in Arabidopsis,” Nature, vol. 415, no. 6873. Nature Publishing Group, pp. 806–809, 2002. ista: Friml J, Wiśniewska J, Benková E, Mendgen K, Palme K. 2002. Lateral relocation of auxin efflux regulator PIN3 mediates tropism in Arabidopsis. Nature. 415(6873), 806–809. mla: Friml, Jiří, et al. “Lateral Relocation of Auxin Efflux Regulator PIN3 Mediates Tropism in Arabidopsis.” Nature, vol. 415, no. 6873, Nature Publishing Group, 2002, pp. 806–09, doi:10.1038/415806a. short: J. Friml, J. Wiśniewska, E. Benková, K. Mendgen, K. Palme, Nature 415 (2002) 806–809. date_created: 2018-12-11T12:00:42Z date_published: 2002-02-14T00:00:00Z date_updated: 2023-07-18T07:30:27Z day: '14' doi: 10.1038/415806a extern: '1' external_id: pmid: - '11845211 ' intvolume: ' 415' issue: '6873' language: - iso: eng month: '02' oa_version: None page: 806 - 809 pmid: 1 publication: Nature publication_identifier: issn: - 0028-0836 publication_status: published publisher: Nature Publishing Group publist_id: '3715' quality_controlled: '1' scopus_import: '1' status: public title: Lateral relocation of auxin efflux regulator PIN3 mediates tropism in Arabidopsis type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 415 year: '2002' ... --- _id: '2987' abstract: - lang: eng text: The hydra mutants of Arabidopsis are characterized by a pleiotropic phenotype that shows defective embryonic and seedling cell patterning, morphogenesis, and root growth. We demonstrate that the HYDRA1 gene encodes a Δ8-Δ7 sterol isomerase, whereas HYDRA2 encodes a sterol C14 reductase, previously identified as the FACKEL gene product. Seedlings mutant for each gene are similarly defective in the concentrations of the three major Arabidopsis sterols. Promoter::reporter gene analysis showed misexpression of the auxin-regulated DR5 and ACS1 promoters and of the epidermal cell file-specific GL2 promoter in the mutants. The mutants exhibit enhanced responses to auxin. The phenotypes can be rescued partially by inhibition of auxin and ethylene signaling but not by exogenous sterols or brassinosteroids. We propose a model in which correct sterol profiles are required for regulated auxin and ethylene signaling through effects on membrane function. acknowledgement: We thank Dr. Ken Feldmann for providing prospective hyd alleles, Dr. Jane Murfett for providing DR5::GUS seed, Dr. D. Van Der Straeten for providing ACS1::GUS seed, Dr. John Schiefelbein for providing GL2::GFP seed, and Dr. Ottoline Leyser for axr1-12 and axr3-1 seed. etr1 and fk seed was obtained from the Nottingham Arabidopsis Stock Centre. This work was supported by a Biotechnology and Biological Science Research Council research studentship to M.S., a Durham University studentship to M.P., and Biotechnology and Biological Science Research Council Grant 12/P02330 to J.T. article_processing_charge: No article_type: original author: - first_name: Martin full_name: Souter, Martin last_name: Souter - first_name: Jennifer full_name: Topping, Jennifer last_name: Topping - first_name: Margaret full_name: Pullen, Margaret last_name: Pullen - first_name: Jirí full_name: Friml, Jirí id: 4159519E-F248-11E8-B48F-1D18A9856A87 last_name: Friml orcid: 0000-0002-8302-7596 - first_name: Klaus full_name: Palme, Klaus last_name: Palme - first_name: Rachel full_name: Hackett, Rachel last_name: Hackett - first_name: Don full_name: Grierson, Don last_name: Grierson - first_name: Keith full_name: Lindsey, Keith last_name: Lindsey citation: ama: Souter M, Topping J, Pullen M, et al. Hydra mutants of Arabidopsis are defective in sterol profiles and auxin and ethylene signaling. Plant Cell. 2002;14(5):1017-1031. doi:10.1105/tpc.001248 apa: Souter, M., Topping, J., Pullen, M., Friml, J., Palme, K., Hackett, R., … Lindsey, K. (2002). Hydra mutants of Arabidopsis are defective in sterol profiles and auxin and ethylene signaling. Plant Cell. American Society of Plant Biologists. https://doi.org/10.1105/tpc.001248 chicago: Souter, Martin, Jennifer Topping, Margaret Pullen, Jiří Friml, Klaus Palme, Rachel Hackett, Don Grierson, and Keith Lindsey. “Hydra Mutants of Arabidopsis Are Defective in Sterol Profiles and Auxin and Ethylene Signaling.” Plant Cell. American Society of Plant Biologists, 2002. https://doi.org/10.1105/tpc.001248. ieee: M. Souter et al., “Hydra mutants of Arabidopsis are defective in sterol profiles and auxin and ethylene signaling,” Plant Cell, vol. 14, no. 5. American Society of Plant Biologists, pp. 1017–1031, 2002. ista: Souter M, Topping J, Pullen M, Friml J, Palme K, Hackett R, Grierson D, Lindsey K. 2002. Hydra mutants of Arabidopsis are defective in sterol profiles and auxin and ethylene signaling. Plant Cell. 14(5), 1017–1031. mla: Souter, Martin, et al. “Hydra Mutants of Arabidopsis Are Defective in Sterol Profiles and Auxin and Ethylene Signaling.” Plant Cell, vol. 14, no. 5, American Society of Plant Biologists, 2002, pp. 1017–31, doi:10.1105/tpc.001248. short: M. Souter, J. Topping, M. Pullen, J. Friml, K. Palme, R. Hackett, D. Grierson, K. Lindsey, Plant Cell 14 (2002) 1017–1031. date_created: 2018-12-11T12:00:42Z date_published: 2002-05-01T00:00:00Z date_updated: 2023-07-18T07:34:32Z day: '01' doi: 10.1105/tpc.001248 extern: '1' external_id: pmid: - '12034894' intvolume: ' 14' issue: '5' language: - iso: eng main_file_link: - open_access: '1' url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC150604/ month: '05' oa: 1 oa_version: None page: 1017 - 1031 pmid: 1 publication: Plant Cell publication_identifier: issn: - 1040-4651 publication_status: published publisher: American Society of Plant Biologists publist_id: '3716' quality_controlled: '1' scopus_import: '1' status: public title: Hydra mutants of Arabidopsis are defective in sterol profiles and auxin and ethylene signaling type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 14 year: '2002' ... --- _id: '2866' abstract: - lang: eng text: 'Developmental responses to the plant hormone auxin are thought to be mediated by interacting pairs from two protein families: short-lived inhibitory IAA proteins and ARF transcription factors binding to auxin-response elements. Monopteros mutants lacking activating ARF5 and the auxin-insensitive mutant bodenlos fail to initiate the root meristem during early embryogenesis. Here we show that the bodenlos phenotype results from an amino-acid exchange in the conserved degradation domain of IAA12. BODENLOS and MONOPTEROS interact in the yeast two-hybrid assay and the two genes are coexpressed in early embryogenesis, suggesting that BODENLOS inhibits MONOPTEROS action in root meristem initiation.' acknowledgement: "We thank C. Maulbetsch for isolating BDL cDNA clones; T. Berleth and J. Friml for providing clones for in situ probes; K. Harter for making available the parsley protoplast system; and J. Friml, N. Geldner, M. Griffith, C. Schwechheimer, D. Weigel, and D. Weijers for helpful comments and critical reading of the manuscript. This work was supported by Sonderforschungsbereich 446 “Mechanismen des Zellverhaltens bei Eukaryoten.”\r\n\r\nThe publication costs of this article were defrayed in part by payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 USC section 1734 solely to indicate this fact." article_processing_charge: No article_type: original author: - first_name: Thorsten full_name: Hamann, Thorsten last_name: Hamann - first_name: Eva full_name: Benková, Eva id: 38F4F166-F248-11E8-B48F-1D18A9856A87 last_name: Benková orcid: 0000-0002-8510-9739 - first_name: Isabel full_name: Bäurle, Isabel last_name: Bäurle - first_name: Marika full_name: Kientz, Marika last_name: Kientz - first_name: Gerd full_name: Jürgens, Gerd last_name: Jürgens citation: ama: Hamann T, Benková E, Bäurle I, Kientz M, Jürgens G. The Arabidopsis BODENLOS gene encodes an auxin response protein inhibiting MONOPTEROS-mediated embryo patterning. Genes and Development. 2002;16(13):1610-1615. doi:10.1101/gad.229402 apa: Hamann, T., Benková, E., Bäurle, I., Kientz, M., & Jürgens, G. (2002). The Arabidopsis BODENLOS gene encodes an auxin response protein inhibiting MONOPTEROS-mediated embryo patterning. Genes and Development. Cold Spring Harbor Laboratory Press. https://doi.org/10.1101/gad.229402 chicago: Hamann, Thorsten, Eva Benková, Isabel Bäurle, Marika Kientz, and Gerd Jürgens. “The Arabidopsis BODENLOS Gene Encodes an Auxin Response Protein Inhibiting MONOPTEROS-Mediated Embryo Patterning.” Genes and Development. Cold Spring Harbor Laboratory Press, 2002. https://doi.org/10.1101/gad.229402. ieee: T. Hamann, E. Benková, I. Bäurle, M. Kientz, and G. Jürgens, “The Arabidopsis BODENLOS gene encodes an auxin response protein inhibiting MONOPTEROS-mediated embryo patterning,” Genes and Development, vol. 16, no. 13. Cold Spring Harbor Laboratory Press, pp. 1610–1615, 2002. ista: Hamann T, Benková E, Bäurle I, Kientz M, Jürgens G. 2002. The Arabidopsis BODENLOS gene encodes an auxin response protein inhibiting MONOPTEROS-mediated embryo patterning. Genes and Development. 16(13), 1610–1615. mla: Hamann, Thorsten, et al. “The Arabidopsis BODENLOS Gene Encodes an Auxin Response Protein Inhibiting MONOPTEROS-Mediated Embryo Patterning.” Genes and Development, vol. 16, no. 13, Cold Spring Harbor Laboratory Press, 2002, pp. 1610–15, doi:10.1101/gad.229402. short: T. Hamann, E. Benková, I. Bäurle, M. Kientz, G. Jürgens, Genes and Development 16 (2002) 1610–1615. date_created: 2018-12-11T12:00:01Z date_published: 2002-07-01T00:00:00Z date_updated: 2023-07-18T08:26:58Z day: '01' doi: 10.1101/gad.229402 extern: '1' external_id: pmid: - '12101120' intvolume: ' 16' issue: '13' language: - iso: eng main_file_link: - open_access: '1' url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC186366/ month: '07' oa: 1 oa_version: Published Version page: 1610 - 1615 pmid: 1 publication: Genes and Development publication_identifier: issn: - 0890-9369 publication_status: published publisher: Cold Spring Harbor Laboratory Press publist_id: '3921' quality_controlled: '1' scopus_import: '1' status: public title: The Arabidopsis BODENLOS gene encodes an auxin response protein inhibiting MONOPTEROS-mediated embryo patterning type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 16 year: '2002' ... --- _id: '2927' abstract: - lang: eng text: 'In the last few years, several new algorithms based on graph cuts have been developed to solve energy minimization problems in computer vision. Each of these techniques constructs a graph such that the minimum cut on the graph also minimizes the energy. Yet because these graph constructions are complex and highly specific to a particular energy function, graph cuts have seen limited application to date. In this paper we characterize the energy functions that can be minimized by graph cuts. Our results are restricted to energy functions with binary variables. However, our work generalizes many previous constructions, and is easily applicable to vision problems that involve large numbers of labels, such as stereo, motion, image restoration and scene reconstruction. We present three main results: a necessary condition for any energy function that can be minimized by graph cuts; a sufficient condition for energy functions that can be written as a sum of functions of up to three variables at a time; and a general-purpose construction to minimize such an energy function. Researchers who are considering the use of graph cuts to optimize a particular energy function can use our results to determine if this is possible, and then follow our construction to create the appropriate graph.' acknowledgement: We thank Olga Veksler and Yuri Boykov for their careful reading of this paper, and for valuable comments which greatly improved itsreadibility. We also thank Ian Jermyn for helping us clarify the paper’s motivation. This research was supported by NSF grants IIS-9900115 and CCR-0113371, and by a grant from Microsoft Research. article_processing_charge: No author: - first_name: Vladimir full_name: Kolmogorov, Vladimir id: 3D50B0BA-F248-11E8-B48F-1D18A9856A87 last_name: Kolmogorov - first_name: Ramin full_name: Zabih, Ramin last_name: Zabih citation: ama: 'Kolmogorov V, Zabih R. Multi-camera scene reconstruction via graph cuts. In: Proceedings of the 7th European Conference on Computer Vision. Springer; 2002:65-81. doi:10.1007/3-540-47977-5_5' apa: 'Kolmogorov, V., & Zabih, R. (2002). Multi-camera scene reconstruction via graph cuts. In Proceedings of the 7th European Conference on Computer Vision (pp. 65–81). Copenhagen, Denmark: Springer. https://doi.org/10.1007/3-540-47977-5_5' chicago: Kolmogorov, Vladimir, and Ramin Zabih. “Multi-Camera Scene Reconstruction via Graph Cuts.” In Proceedings of the 7th European Conference on Computer Vision, 65–81. Springer, 2002. https://doi.org/10.1007/3-540-47977-5_5. ieee: V. Kolmogorov and R. Zabih, “Multi-camera scene reconstruction via graph cuts,” in Proceedings of the 7th European Conference on Computer Vision, Copenhagen, Denmark, 2002, pp. 65–81. ista: 'Kolmogorov V, Zabih R. 2002. Multi-camera scene reconstruction via graph cuts. Proceedings of the 7th European Conference on Computer Vision. ECCV: European Conference on Computer Vision, 65–81.' mla: Kolmogorov, Vladimir, and Ramin Zabih. “Multi-Camera Scene Reconstruction via Graph Cuts.” Proceedings of the 7th European Conference on Computer Vision, Springer, 2002, pp. 65–81, doi:10.1007/3-540-47977-5_5. short: V. Kolmogorov, R. Zabih, in:, Proceedings of the 7th European Conference on Computer Vision, Springer, 2002, pp. 65–81. conference: end_date: 2002-05-31 location: Copenhagen, Denmark name: 'ECCV: European Conference on Computer Vision' start_date: 2002-05-28 date_created: 2018-12-11T12:00:23Z date_published: 2002-01-01T00:00:00Z date_updated: 2023-07-18T08:20:02Z day: '01' doi: 10.1007/3-540-47977-5_5 extern: '1' language: - iso: eng month: '01' oa_version: None page: 65 - 81 publication: Proceedings of the 7th European Conference on Computer Vision publication_identifier: isbn: - '9783540437468' publication_status: published publisher: Springer publist_id: '3810' quality_controlled: '1' scopus_import: '1' status: public title: Multi-camera scene reconstruction via graph cuts type: conference user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 year: '2002' ... --- _id: '2739' abstract: - lang: eng text: We define the two dimensional Pauli operator and identify its core for magnetic fields that are regular Borel measures. The magnetic field is generated by a scalar potential hence we bypass the usual A L 2loc condition on the vector potential, which does not allow to consider such singular fields. We extend the Aharonov-Casher theorem for magnetic fields that are measures with finite total variation and we present a counterexample in case of infinite total variation. One of the key technical tools is a weighted L 2 estimate on a singular integral operator. acknowledgement: "This work started during the first author’s visit at the Erwin Schrödinger Institute, Vienna.\r\nValuable discussions with T. Hoffmann-Ostenhof and M. Loss are gratefully acknowledged. The authors thank\r\nthe referee for careful reading and comments" article_processing_charge: No article_type: original author: - first_name: László full_name: Erdös, László id: 4DBD5372-F248-11E8-B48F-1D18A9856A87 last_name: Erdös orcid: 0000-0001-5366-9603 - first_name: Vitali full_name: Vougalter, Vitali last_name: Vougalter citation: ama: Erdös L, Vougalter V. Pauli operator and Aharonov–Casher theorem¶ for measure valued magnetic fields. Communications in Mathematical Physics. 2002;225(2):399-421. doi:10.1007/s002200100585 apa: Erdös, L., & Vougalter, V. (2002). Pauli operator and Aharonov–Casher theorem¶ for measure valued magnetic fields. Communications in Mathematical Physics. Springer. https://doi.org/10.1007/s002200100585 chicago: Erdös, László, and Vitali Vougalter. “Pauli Operator and Aharonov–Casher Theorem¶ for Measure Valued Magnetic Fields.” Communications in Mathematical Physics. Springer, 2002. https://doi.org/10.1007/s002200100585. ieee: L. Erdös and V. Vougalter, “Pauli operator and Aharonov–Casher theorem¶ for measure valued magnetic fields,” Communications in Mathematical Physics, vol. 225, no. 2. Springer, pp. 399–421, 2002. ista: Erdös L, Vougalter V. 2002. Pauli operator and Aharonov–Casher theorem¶ for measure valued magnetic fields. Communications in Mathematical Physics. 225(2), 399–421. mla: Erdös, László, and Vitali Vougalter. “Pauli Operator and Aharonov–Casher Theorem¶ for Measure Valued Magnetic Fields.” Communications in Mathematical Physics, vol. 225, no. 2, Springer, 2002, pp. 399–421, doi:10.1007/s002200100585. short: L. Erdös, V. Vougalter, Communications in Mathematical Physics 225 (2002) 399–421. date_created: 2018-12-11T11:59:21Z date_published: 2002-02-01T00:00:00Z date_updated: 2023-07-18T08:57:54Z day: '01' doi: 10.1007/s002200100585 extern: '1' external_id: arxiv: - math-ph/0109015v1 intvolume: ' 225' issue: '2' language: - iso: eng month: '02' oa_version: None page: 399 - 421 publication: Communications in Mathematical Physics publication_identifier: issn: - 0010-3616 publication_status: published publisher: Springer publist_id: '4153' quality_controlled: '1' scopus_import: '1' status: public title: Pauli operator and Aharonov–Casher theorem¶ for measure valued magnetic fields type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 225 year: '2002' ... --- _id: '2738' abstract: - lang: eng text: We consider the long time evolution of a quantum particle weakly interacting with a phonon field. We show that in the weak coupling limit the Wigner distribution of the electron density matrix converges to the solution of the linear Boltzmann equation globally in time. The collision kernel is identified as the sum of an emission and an absorption term that depend on the equilibrium distribution of the free phonon modes. acknowledgement: "This work initially was a joint project with H.-T. Yau and several ideas\r\npresented here have been developed in collaboration with him. I would like\r\nto thank him for the invaluable discussions and encouragement through\r\nthe entire work. Part of this project was completed during several visits at\r\nthe Erwin Schrödinger Institute, Vienna, and at the Center of Theoretical\r\nStudies, Hsinchu, Taiwan. The author is grateful for the hospitality and\r\nfinancial support. This work was partially supported by NSF Grant DMS9970323." article_processing_charge: No article_type: original author: - first_name: László full_name: Erdös, László id: 4DBD5372-F248-11E8-B48F-1D18A9856A87 last_name: Erdös orcid: 0000-0001-5366-9603 citation: ama: Erdös L. Linear Boltzmann equation as the long time dynamics of an electron weakly coupled to a phonon field. Journal of Statistical Physics. 2002;107(5-6):1043-1127. doi:10.1023/A:1015157624384 apa: Erdös, L. (2002). Linear Boltzmann equation as the long time dynamics of an electron weakly coupled to a phonon field. Journal of Statistical Physics. Springer. https://doi.org/10.1023/A:1015157624384 chicago: Erdös, László. “Linear Boltzmann Equation as the Long Time Dynamics of an Electron Weakly Coupled to a Phonon Field.” Journal of Statistical Physics. Springer, 2002. https://doi.org/10.1023/A:1015157624384. ieee: L. Erdös, “Linear Boltzmann equation as the long time dynamics of an electron weakly coupled to a phonon field,” Journal of Statistical Physics, vol. 107, no. 5–6. Springer, pp. 1043–1127, 2002. ista: Erdös L. 2002. Linear Boltzmann equation as the long time dynamics of an electron weakly coupled to a phonon field. Journal of Statistical Physics. 107(5–6), 1043–1127. mla: Erdös, László. “Linear Boltzmann Equation as the Long Time Dynamics of an Electron Weakly Coupled to a Phonon Field.” Journal of Statistical Physics, vol. 107, no. 5–6, Springer, 2002, pp. 1043–127, doi:10.1023/A:1015157624384. short: L. Erdös, Journal of Statistical Physics 107 (2002) 1043–1127. date_created: 2018-12-11T11:59:20Z date_published: 2002-06-01T00:00:00Z date_updated: 2023-07-18T09:08:45Z day: '01' doi: 10.1023/A:1015157624384 extern: '1' external_id: arxiv: - math-ph/0108025 intvolume: ' 107' issue: 5-6 language: - iso: eng month: '06' oa_version: Submitted Version page: 1043 - 1127 publication: Journal of Statistical Physics publication_identifier: issn: - 0022-4715 publication_status: published publisher: Springer publist_id: '4154' quality_controlled: '1' scopus_import: '1' status: public title: Linear Boltzmann equation as the long time dynamics of an electron weakly coupled to a phonon field type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 107 year: '2002' ... --- _id: '2740' abstract: - lang: eng text: We show that the lowest eigenvalue of the magnetic Schrödinger operator on a line bundle over a compact Riemann surface M is bounded by the L1-norm of the magnetic field B. This implies a similar bound on the multiplicity of the ground state. An example shows that this degeneracy can indeed be comparable with ∫M |B| even in case of the trivial bundle. article_processing_charge: No article_type: original author: - first_name: László full_name: Erdös, László id: 4DBD5372-F248-11E8-B48F-1D18A9856A87 last_name: Erdös orcid: 0000-0001-5366-9603 citation: ama: Erdös L. Spectral shift and multiplicity of the first eigenvalue of the magnetic Schrödinger operator in two dimensions. Annales de l’Institut Fourier. 2002;52(6):1833-1874. doi:10.5802/aif.1936 apa: Erdös, L. (2002). Spectral shift and multiplicity of the first eigenvalue of the magnetic Schrödinger operator in two dimensions. Annales de l’Institut Fourier. Association des Annales de l’Institut Fourier. https://doi.org/10.5802/aif.1936 chicago: Erdös, László. “Spectral Shift and Multiplicity of the First Eigenvalue of the Magnetic Schrödinger Operator in Two Dimensions.” Annales de l’Institut Fourier. Association des Annales de l’Institut Fourier, 2002. https://doi.org/10.5802/aif.1936. ieee: L. Erdös, “Spectral shift and multiplicity of the first eigenvalue of the magnetic Schrödinger operator in two dimensions,” Annales de l’Institut Fourier, vol. 52, no. 6. Association des Annales de l’Institut Fourier, pp. 1833–1874, 2002. ista: Erdös L. 2002. Spectral shift and multiplicity of the first eigenvalue of the magnetic Schrödinger operator in two dimensions. Annales de l’Institut Fourier. 52(6), 1833–1874. mla: Erdös, László. “Spectral Shift and Multiplicity of the First Eigenvalue of the Magnetic Schrödinger Operator in Two Dimensions.” Annales de l’Institut Fourier, vol. 52, no. 6, Association des Annales de l’Institut Fourier, 2002, pp. 1833–74, doi:10.5802/aif.1936. short: L. Erdös, Annales de l’Institut Fourier 52 (2002) 1833–1874. date_created: 2018-12-11T11:59:21Z date_published: 2002-01-01T00:00:00Z date_updated: 2023-07-18T08:38:34Z day: '01' doi: 10.5802/aif.1936 extern: '1' intvolume: ' 52' issue: '6' language: - iso: eng month: '01' oa_version: None page: 1833-1874 publication: Annales de l'Institut Fourier publication_identifier: issn: - 0373-0956 publication_status: published publisher: Association des Annales de l'Institut Fourier publist_id: '4152' quality_controlled: '1' scopus_import: '1' status: public title: Spectral shift and multiplicity of the first eigenvalue of the magnetic Schrödinger operator in two dimensions type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 52 year: '2002' ... --- _id: '2737' abstract: - lang: eng text: We derive the time-dependent Schrödinger–Poisson equation as the weak coupling limit of the N-body linear Schrödinger equation with Coulomb potential. acknowledgement: "The authors thank the ESI in Vienna and the Austrian START project “Nonlinear Schrödinger\r\nand quantum Boltzmann equations” of N.J.M. for hospitality and support. Also, F.G. was supported by the Institut\r\nUniversitaire de France and N.J.M. by the bilateral Austrian-French “AMADEUS” programme. H.-T.Y. and L.E. were\r\nsupported by NSF Grants DMS-0072098 and DMS-9970323, respectively" article_processing_charge: No article_type: original author: - first_name: Claude full_name: Bardos, Claude last_name: Bardos - first_name: László full_name: Erdös, László id: 4DBD5372-F248-11E8-B48F-1D18A9856A87 last_name: Erdös orcid: 0000-0001-5366-9603 - first_name: François full_name: Golse, François last_name: Golse - first_name: Norbert full_name: Mauser, Norbert last_name: Mauser - first_name: Horng full_name: Yau, Horng last_name: Yau citation: ama: Bardos C, Erdös L, Golse F, Mauser N, Yau H. Derivation of the Schrödinger-Poisson equation from the quantum N-body problem. Comptes Rendus Mathematique. 2002;334(6):515-520. doi:10.1016/S1631-073X(02)02253-7 apa: Bardos, C., Erdös, L., Golse, F., Mauser, N., & Yau, H. (2002). Derivation of the Schrödinger-Poisson equation from the quantum N-body problem. Comptes Rendus Mathematique. Elsevier. https://doi.org/10.1016/S1631-073X(02)02253-7 chicago: Bardos, Claude, László Erdös, François Golse, Norbert Mauser, and Horng Yau. “Derivation of the Schrödinger-Poisson Equation from the Quantum N-Body Problem.” Comptes Rendus Mathematique. Elsevier, 2002. https://doi.org/10.1016/S1631-073X(02)02253-7. ieee: C. Bardos, L. Erdös, F. Golse, N. Mauser, and H. Yau, “Derivation of the Schrödinger-Poisson equation from the quantum N-body problem,” Comptes Rendus Mathematique, vol. 334, no. 6. Elsevier, pp. 515–520, 2002. ista: Bardos C, Erdös L, Golse F, Mauser N, Yau H. 2002. Derivation of the Schrödinger-Poisson equation from the quantum N-body problem. Comptes Rendus Mathematique. 334(6), 515–520. mla: Bardos, Claude, et al. “Derivation of the Schrödinger-Poisson Equation from the Quantum N-Body Problem.” Comptes Rendus Mathematique, vol. 334, no. 6, Elsevier, 2002, pp. 515–20, doi:10.1016/S1631-073X(02)02253-7. short: C. Bardos, L. Erdös, F. Golse, N. Mauser, H. Yau, Comptes Rendus Mathematique 334 (2002) 515–520. date_created: 2018-12-11T11:59:20Z date_published: 2002-03-30T00:00:00Z date_updated: 2023-07-18T09:24:24Z day: '30' doi: 10.1016/S1631-073X(02)02253-7 extern: '1' intvolume: ' 334' issue: '6' language: - iso: eng month: '03' oa_version: None page: 515 - 520 publication: Comptes Rendus Mathematique publication_identifier: issn: - 1631-073X publication_status: published publisher: Elsevier publist_id: '4155' quality_controlled: '1' scopus_import: '1' status: public title: Derivation of the Schrödinger-Poisson equation from the quantum N-body problem type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 334 year: '2002' ... --- _id: '2624' abstract: - lang: eng text: Metabotropic γ-aminobutyric acid receptors (GABABRs) are involved in modulation of synaptic transmission and activity of cerebellar and thalamic neurons. We used subtype-specific antibodies in pre- and postembedding immunohistochemistry combined with three-dimensional reconstruction of labelled profiles and quantification of immunoparticles to reveal the subcellular distribution of pre- and postsynaptic GABABR1a/b and GABABR2 in the rat cerebellum and ventrobasal thalamus. GABABR1a/b and R2 were extensively colocalized in most brain regions including the cerebellum and thalamus. In the cerebellum, immunoreactivity for both subtypes was prevalent in the molecular layer. The most intense immunoreactivity was found in Purkinje cell spines with a high density of immunoparticles at extrasynaptic sites peaking at around 240 nm from glutamatergic synapses between spines and parallel fibre varicosities. This is in contrast to dendrites at sites around GABAergic synapses where sparse and random distribution was found for both subtypes. In addition, more than one-tenth of the synaptic membrane specialization of spine-parallel fibre synapses were labelled at pre- or postsynaptic sites. Weak immunolabelling for both subtypes was also seen in parallel fibres but only rarely in GABAergic axons. In the ventrobasal thalamus, immunolabelling for both receptor subtypes was intense over the dendritic field of thalamocortical cells. Electron microscopy demonstrated an extrasynaptic localization of GABABR1a/b and R2 exclusively in postsynaptic elements. Quantitative analysis further revealed the density of GABABR1a/b around GABAergic synapses was higher than glutamatergic synapses on thalamocortical cell dendrites. The distinct localization of GABABRs relative to synaptic sites in the cerebellum and ventrobasal thalamus suggests that GABABRs differentially regulate activity of different neuronal populations. acknowledgement: This work was supported by research grants from the Ministry of Education, Science, Sports and Culture of Japan, and the Japan Society for the Promotion of Science (P96319). We thank Drs L. Zaborszky and R. Luján for their comments on the manuscript, Dr M. Watanabe for kindly supplying us with GluRδ2 and AMPA GluR1 antibodies, Dr R.E. Edwards for rabbit BNPI antibody, and J. Hatakeyama and S. Doi for technical assistance. article_processing_charge: No article_type: original author: - first_name: Ákos full_name: Kulik, Ákos last_name: Kulik - first_name: Kazuhiko full_name: Nakadate, Kazuhiko last_name: Nakadate - first_name: Gábor full_name: Nyíri, Gábor last_name: Nyíri - first_name: Takuya full_name: Notomi, Takuya last_name: Notomi - first_name: Barbara full_name: Malitschek, Barbara last_name: Malitschek - first_name: Bernhard full_name: Bettler, Bernhard last_name: Bettler - first_name: Ryuichi full_name: Shigemoto, Ryuichi id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 citation: ama: Kulik Á, Nakadate K, Nyíri G, et al. Distinct localization of GABAB receptors relative to synaptic sites in the rat cerebellum and ventrobasal thalamus. European Journal of Neuroscience. 2002;15(2):291-307. doi:10.1046/j.0953-816x.2001.01855.x apa: Kulik, Á., Nakadate, K., Nyíri, G., Notomi, T., Malitschek, B., Bettler, B., & Shigemoto, R. (2002). Distinct localization of GABAB receptors relative to synaptic sites in the rat cerebellum and ventrobasal thalamus. European Journal of Neuroscience. Wiley-Blackwell. https://doi.org/10.1046/j.0953-816x.2001.01855.x chicago: Kulik, Ákos, Kazuhiko Nakadate, Gábor Nyíri, Takuya Notomi, Barbara Malitschek, Bernhard Bettler, and Ryuichi Shigemoto. “Distinct Localization of GABAB Receptors Relative to Synaptic Sites in the Rat Cerebellum and Ventrobasal Thalamus.” European Journal of Neuroscience. Wiley-Blackwell, 2002. https://doi.org/10.1046/j.0953-816x.2001.01855.x. ieee: Á. Kulik et al., “Distinct localization of GABAB receptors relative to synaptic sites in the rat cerebellum and ventrobasal thalamus,” European Journal of Neuroscience, vol. 15, no. 2. Wiley-Blackwell, pp. 291–307, 2002. ista: Kulik Á, Nakadate K, Nyíri G, Notomi T, Malitschek B, Bettler B, Shigemoto R. 2002. Distinct localization of GABAB receptors relative to synaptic sites in the rat cerebellum and ventrobasal thalamus. European Journal of Neuroscience. 15(2), 291–307. mla: Kulik, Ákos, et al. “Distinct Localization of GABAB Receptors Relative to Synaptic Sites in the Rat Cerebellum and Ventrobasal Thalamus.” European Journal of Neuroscience, vol. 15, no. 2, Wiley-Blackwell, 2002, pp. 291–307, doi:10.1046/j.0953-816x.2001.01855.x. short: Á. Kulik, K. Nakadate, G. Nyíri, T. Notomi, B. Malitschek, B. Bettler, R. Shigemoto, European Journal of Neuroscience 15 (2002) 291–307. date_created: 2018-12-11T11:58:44Z date_published: 2002-01-01T00:00:00Z date_updated: 2023-07-18T13:08:40Z day: '01' doi: 10.1046/j.0953-816x.2001.01855.x extern: '1' external_id: pmid: - '11849296' intvolume: ' 15' issue: '2' language: - iso: eng month: '01' oa_version: None page: 291 - 307 pmid: 1 publication: European Journal of Neuroscience publication_identifier: issn: - 0953-816X publication_status: published publisher: Wiley-Blackwell publist_id: '4275' quality_controlled: '1' scopus_import: '1' status: public title: Distinct localization of GABAB receptors relative to synaptic sites in the rat cerebellum and ventrobasal thalamus type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 15 year: '2002' ... --- _id: '2694' abstract: - lang: eng text: We outline the status of rigorous derivations of certain classical evolution equations as limits of Schrödinger dynamics. We explain two recent results jointly with H.T. Yau in more details. The first one is the derivation of the linear Boltzmann equation as the long time limit of the one-body Schrödinger equation with a random potential. The second one is the mean field limit of high density bosons with Coulomb interaction that leads to the nonlinear Hartree equation. alternative_title: - LNP article_processing_charge: No author: - first_name: László full_name: Erdös, László id: 4DBD5372-F248-11E8-B48F-1D18A9856A87 last_name: Erdös orcid: 0000-0001-5366-9603 citation: ama: 'Erdös L. Scaling limits of Schrödinger quantum mechanics. In: Dynamics of Dissipation. Lecture Notes in Physics. Springer; 2002:487-506. doi:10.1007/3-540-46122-1_19' apa: Erdös, L. (2002). Scaling limits of Schrödinger quantum mechanics. In Dynamics of Dissipation (pp. 487–506). Springer. https://doi.org/10.1007/3-540-46122-1_19 chicago: Erdös, László. “Scaling Limits of Schrödinger Quantum Mechanics.” In Dynamics of Dissipation, 487–506. Lecture Notes in Physics. Springer, 2002. https://doi.org/10.1007/3-540-46122-1_19. ieee: L. Erdös, “Scaling limits of Schrödinger quantum mechanics,” in Dynamics of Dissipation, Springer, 2002, pp. 487–506. ista: 'Erdös L. 2002.Scaling limits of Schrödinger quantum mechanics. In: Dynamics of Dissipation. LNP, , 487–506.' mla: Erdös, László. “Scaling Limits of Schrödinger Quantum Mechanics.” Dynamics of Dissipation, Springer, 2002, pp. 487–506, doi:10.1007/3-540-46122-1_19. short: L. Erdös, in:, Dynamics of Dissipation, Springer, 2002, pp. 487–506. conference: name: '38th Winter School of Theoretical Physics : Dynamical Semigroups: Dissipation, Chaos, Quanta' date_created: 2018-12-11T11:59:06Z date_published: 2002-01-01T00:00:00Z date_updated: 2023-07-18T10:23:18Z day: '01' doi: 10.1007/3-540-46122-1_19 extern: '1' language: - iso: eng month: '01' oa_version: None page: 487 - 506 publication: Dynamics of Dissipation publication_identifier: isbn: - '9783540441113' publication_status: published publisher: Springer publist_id: '4203' quality_controlled: '1' series_title: Lecture Notes in Physics status: public title: Scaling limits of Schrödinger quantum mechanics type: book_chapter user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 year: '2002' ... --- _id: '2622' abstract: - lang: eng text: To understand the possible contribution of metabotropic γ-aminobutyric acid receptors (GABABR) in cortical development, we investigated the expression pattern and the cellular and subcellular localization of the GABABR1 and GABABR2 subtypes in the rat neocortex from embryonic day 14 (E14) to adulthood. At the light microscopic level, both GABABR1 and GABABR2 were detected as early as E14. During prenatal development, both subtypes were expressed highly in the cortical plate. Using double immunofluorescence, GABABR1 colocalized with GABABR2 in neurons of the marginal zone and subplate, indicating that these proteins are coexpressed and could be forming functional GABABRs during prenatal development in vivo. In contrast, only GABABR1 but not GABABR2 was detected in the tangentially migratory cells in the lower intermediate zone. During postnatal development, immunoreactivity for GABABR1 and GABABR2 was distributed mainly in pyramidal cells. Discrete GABABR1-immunopositive cell bodies of interneurons were present throughout the neocortex. In addition, GABABR1 but not GABABR2 was found in identified Cajal-Retzius cells in layer I. At the electron microscopic level, immunoreactivity for GABABR1 and GABABR2 was found in dendritic spines and dendritic shafts at extrasynaptic and perisynaptic sites throughout postnatal development. We further demonstrated the presynaptic localization of GABABR1 and GABABR2, as well as the association of the receptors with asymmetrical synaptic junctions. These results indicate potentially important roles for the GABABRs in the regulation of migratory processes during corticogenesis and in the modulation of synaptic transmission during early development of cortical circuitry. acknowledgement: The authors are grateful to Dr Marco Sassoe-Pogneto for his comments on a previous version of the manuscript. We also would like to thank to Ms. Courtney Voelker for the English revision and comments of the manuscript. This work was made possible by grants from the European Community (QLG3-CT-1999–00192, R.L) and the Spanish Ministry of Science and Technology (PB97-0582-CO2-01, A.F). article_processing_charge: No article_type: original author: - first_name: Guillermina full_name: López Bendito, Guillermina last_name: López Bendito - first_name: Ryuichi full_name: Shigemoto, Ryuichi id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 - first_name: Ákos full_name: Kulik, Ákos last_name: Kulik - first_name: Ole full_name: Paulsen, Ole last_name: Paulsen - first_name: Alfonso full_name: Fairén, Alfonso last_name: Fairén - first_name: Rafael full_name: Luján, Rafael last_name: Luján citation: ama: López Bendito G, Shigemoto R, Kulik Á, Paulsen O, Fairén A, Luján R. Expression and distribution of metabotropic GABA receptor subtypes GABABR1 and GABABR2 during rat neocortical development. European Journal of Neuroscience. 2002;15(11):1766-1778. doi:10.1046/j.1460-9568.2002.02032.x apa: López Bendito, G., Shigemoto, R., Kulik, Á., Paulsen, O., Fairén, A., & Luján, R. (2002). Expression and distribution of metabotropic GABA receptor subtypes GABABR1 and GABABR2 during rat neocortical development. European Journal of Neuroscience. Wiley-Blackwell. https://doi.org/10.1046/j.1460-9568.2002.02032.x chicago: López Bendito, Guillermina, Ryuichi Shigemoto, Ákos Kulik, Ole Paulsen, Alfonso Fairén, and Rafael Luján. “Expression and Distribution of Metabotropic GABA Receptor Subtypes GABABR1 and GABABR2 during Rat Neocortical Development.” European Journal of Neuroscience. Wiley-Blackwell, 2002. https://doi.org/10.1046/j.1460-9568.2002.02032.x. ieee: G. López Bendito, R. Shigemoto, Á. Kulik, O. Paulsen, A. Fairén, and R. Luján, “Expression and distribution of metabotropic GABA receptor subtypes GABABR1 and GABABR2 during rat neocortical development,” European Journal of Neuroscience, vol. 15, no. 11. Wiley-Blackwell, pp. 1766–1778, 2002. ista: López Bendito G, Shigemoto R, Kulik Á, Paulsen O, Fairén A, Luján R. 2002. Expression and distribution of metabotropic GABA receptor subtypes GABABR1 and GABABR2 during rat neocortical development. European Journal of Neuroscience. 15(11), 1766–1778. mla: López Bendito, Guillermina, et al. “Expression and Distribution of Metabotropic GABA Receptor Subtypes GABABR1 and GABABR2 during Rat Neocortical Development.” European Journal of Neuroscience, vol. 15, no. 11, Wiley-Blackwell, 2002, pp. 1766–78, doi:10.1046/j.1460-9568.2002.02032.x. short: G. López Bendito, R. Shigemoto, Á. Kulik, O. Paulsen, A. Fairén, R. Luján, European Journal of Neuroscience 15 (2002) 1766–1778. date_created: 2018-12-11T11:58:43Z date_published: 2002-06-01T00:00:00Z date_updated: 2023-07-19T07:30:39Z day: '01' doi: 10.1046/j.1460-9568.2002.02032.x extern: '1' external_id: pmid: - '12081656' intvolume: ' 15' issue: '11' language: - iso: eng month: '06' oa_version: None page: 1766 - 1778 pmid: 1 publication: European Journal of Neuroscience publication_identifier: issn: - 0953-816X publication_status: published publisher: Wiley-Blackwell publist_id: '4276' quality_controlled: '1' scopus_import: '1' status: public title: Expression and distribution of metabotropic GABA receptor subtypes GABABR1 and GABABR2 during rat neocortical development type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 15 year: '2002' ... --- _id: '2621' abstract: - lang: eng text: The release properties of glutamatergic nerve terminals are influenced by a number of factors, including the subtype of voltage-dependent calcium channel and the presence of presynaptic autoreceptors. Group III metabotropic glutamate receptors (mGluRs) mediate feedback inhibition of glutamate release by inhibiting Ca2+ channel activity. By imaging Ca2+ in preparations of cerebrocortical nerve terminals, we show that voltage-dependent Ca2+ channels are distributed in a heterogeneous manner in individual nerve terminals. Presynaptic terminals contained only N-type (47.5%; conotoxin GVIA-sensitive), P/Q-type (3.9%; agatoxin IVA-sensitive), or both N- and P/Q-type (42.6%) Ca2+ channels, although the remainder of the terminals (6.1%) were insensitive to these two toxins. In this preparation, two mGluRs with high and low affinity for L(+)-2-amino-4-phosphonobutyrate were identified by immunocytochemistry as mGluR4 and mGluR7, respectively. These receptors were responsible for 22.2 and 24.1% reduction of glutamate release, and they reduced the Ca2+ response in 24.4 and 30.3% of the nerve terminals, respectively. Interestingly, mGluR4 was largely (73.7%) located in nerve terminals expressing both N- and P/Q-type Ca2+ channels, whereas mGluR7 was predominantly (69.9%) located in N-type Ca2+ channel-expressing terminals. This specific coexpression of different group III mGluRs and Ca2+ channels may endow synaptic terminals with distinct release properties and reveals the existence of a high degree of presynaptic heterogeneity. acknowledgement: We thank M. Sefton for editorial assistance. article_processing_charge: No article_type: original author: - first_name: Carmelo full_name: Millán, Carmelo last_name: Millán - first_name: Rafael full_name: Luján, Rafael last_name: Luján - first_name: Ryuichi full_name: Shigemoto, Ryuichi id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 - first_name: José full_name: Sánchez Prieto, José last_name: Sánchez Prieto citation: ama: Millán C, Luján R, Shigemoto R, Sánchez Prieto J. Subtype-specific expression of Group III metabotropic glutamate receptors and Ca2+ channels in single nerve terminals. Journal of Biological Chemistry. 2002;277(49):47796-47803. doi:10.1074/jbc.M207531200 apa: Millán, C., Luján, R., Shigemoto, R., & Sánchez Prieto, J. (2002). Subtype-specific expression of Group III metabotropic glutamate receptors and Ca2+ channels in single nerve terminals. Journal of Biological Chemistry. American Society for Biochemistry and Molecular Biology. https://doi.org/10.1074/jbc.M207531200 chicago: Millán, Carmelo, Rafael Luján, Ryuichi Shigemoto, and José Sánchez Prieto. “Subtype-Specific Expression of Group III Metabotropic Glutamate Receptors and Ca2+ Channels in Single Nerve Terminals.” Journal of Biological Chemistry. American Society for Biochemistry and Molecular Biology, 2002. https://doi.org/10.1074/jbc.M207531200. ieee: C. Millán, R. Luján, R. Shigemoto, and J. Sánchez Prieto, “Subtype-specific expression of Group III metabotropic glutamate receptors and Ca2+ channels in single nerve terminals,” Journal of Biological Chemistry, vol. 277, no. 49. American Society for Biochemistry and Molecular Biology, pp. 47796–47803, 2002. ista: Millán C, Luján R, Shigemoto R, Sánchez Prieto J. 2002. Subtype-specific expression of Group III metabotropic glutamate receptors and Ca2+ channels in single nerve terminals. Journal of Biological Chemistry. 277(49), 47796–47803. mla: Millán, Carmelo, et al. “Subtype-Specific Expression of Group III Metabotropic Glutamate Receptors and Ca2+ Channels in Single Nerve Terminals.” Journal of Biological Chemistry, vol. 277, no. 49, American Society for Biochemistry and Molecular Biology, 2002, pp. 47796–803, doi:10.1074/jbc.M207531200. short: C. Millán, R. Luján, R. Shigemoto, J. Sánchez Prieto, Journal of Biological Chemistry 277 (2002) 47796–47803. date_created: 2018-12-11T11:58:43Z date_published: 2002-12-02T00:00:00Z date_updated: 2023-07-19T07:49:19Z day: '02' doi: 10.1074/jbc.M207531200 extern: '1' external_id: pmid: - '12376542' intvolume: ' 277' issue: '49' language: - iso: eng month: '12' oa_version: Published Version page: 47796 - 47803 pmid: 1 publication: Journal of Biological Chemistry publication_identifier: issn: - 0021-9258 publication_status: published publisher: American Society for Biochemistry and Molecular Biology publist_id: '4277' quality_controlled: '1' scopus_import: '1' status: public title: Subtype-specific expression of Group III metabotropic glutamate receptors and Ca2+ channels in single nerve terminals type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 277 year: '2002' ... --- _id: '2620' abstract: - lang: eng text: An ion channel's function depends largely on its location and density on neurons. Here we used high-resolution immunolocalization to determine the subcellular distribution of the hyperpolarization-activated and cyclic-nucleotide-gated channel subunit 1 (HCN1) in rat brain. Light microscopy revealed graded HCN1 immunoreactivity in apical dendrites of hippocampal, subicular and neocortical layer-5 pyramidal cells. Quantitative comparison of immunogold densities showed a 60-fold increase from somatic to distal apical dendritic membranes. Distal dendritic shafts had 16 times more HCN1 labeling than proximal dendrites of similar diameters. At the same distance from the soma, the density of HCN1 was significantly higher in dendritic shafts than in spines. Our results reveal the complex cell surface distribution of voltage-gated ion-channels, and predict its role in increasing the computational power of single neurons via subcellular domain and input-specific mechanisms. acknowledgement: Z.N. received grants from the Hungarian Science Foundation (T032309), the Howard Hughes Medical Institute, the James S. McDonnell Foundation, the Wellcome Trust and the Boehringer Ingelheim Fund. Z.N. and R.S. received grants from CREST—Japan Science and Technology Corporation. G.T. is funded by the Wellcome Trust. article_processing_charge: No article_type: original author: - first_name: Andrea full_name: Lörincz, Andrea last_name: Lörincz - first_name: Takuya full_name: Notomi, Takuya last_name: Notomi - first_name: Gábor full_name: Tamás, Gábor last_name: Tamás - first_name: Ryuichi full_name: Shigemoto, Ryuichi id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 - first_name: Zoltán full_name: Nusser, Zoltán last_name: Nusser citation: ama: Lörincz A, Notomi T, Tamás G, Shigemoto R, Nusser Z. Polarized and compartment-dependent distribution of HCN1 in pyramidal cell dendrites. Nature Neuroscience. 2002;5(11):1185-1193. doi:10.1038/nn962 apa: Lörincz, A., Notomi, T., Tamás, G., Shigemoto, R., & Nusser, Z. (2002). Polarized and compartment-dependent distribution of HCN1 in pyramidal cell dendrites. Nature Neuroscience. Nature Publishing Group. https://doi.org/10.1038/nn962 chicago: Lörincz, Andrea, Takuya Notomi, Gábor Tamás, Ryuichi Shigemoto, and Zoltán Nusser. “Polarized and Compartment-Dependent Distribution of HCN1 in Pyramidal Cell Dendrites.” Nature Neuroscience. Nature Publishing Group, 2002. https://doi.org/10.1038/nn962. ieee: A. Lörincz, T. Notomi, G. Tamás, R. Shigemoto, and Z. Nusser, “Polarized and compartment-dependent distribution of HCN1 in pyramidal cell dendrites,” Nature Neuroscience, vol. 5, no. 11. Nature Publishing Group, pp. 1185–1193, 2002. ista: Lörincz A, Notomi T, Tamás G, Shigemoto R, Nusser Z. 2002. Polarized and compartment-dependent distribution of HCN1 in pyramidal cell dendrites. Nature Neuroscience. 5(11), 1185–1193. mla: Lörincz, Andrea, et al. “Polarized and Compartment-Dependent Distribution of HCN1 in Pyramidal Cell Dendrites.” Nature Neuroscience, vol. 5, no. 11, Nature Publishing Group, 2002, pp. 1185–93, doi:10.1038/nn962. short: A. Lörincz, T. Notomi, G. Tamás, R. Shigemoto, Z. Nusser, Nature Neuroscience 5 (2002) 1185–1193. date_created: 2018-12-11T11:58:43Z date_published: 2002-11-01T00:00:00Z date_updated: 2023-07-25T09:02:48Z day: '01' doi: 10.1038/nn962 extern: '1' external_id: pmid: - '12389030' intvolume: ' 5' issue: '11' language: - iso: eng month: '11' oa_version: None page: 1185 - 1193 pmid: 1 publication: Nature Neuroscience publication_identifier: issn: - 1097-6256 publication_status: published publisher: Nature Publishing Group publist_id: '4278' quality_controlled: '1' scopus_import: '1' status: public title: Polarized and compartment-dependent distribution of HCN1 in pyramidal cell dendrites type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 5 year: '2002' ... --- _id: '2614' abstract: - lang: eng text: Metabotropic glutamate receptors (mGluRs) from group III reduce glutamate release. Because these receptors reduce cAMP levels, we explored whether this signaling pathway contributes to release inhibition caused by mGluRs with low affinity for L-2-amino-4-phosphonobutyrate (L-AP4). In biochemical experiments with the population of cerebrocortical nerve terminals we find that L-AP4 (1 mM) inhibited the Ca2+dependent-evoked release of glutamate by 25%. This inhibitory effect was largely prevented by the pertussis toxin but was insensitive to inhibitors of protein kinase C bisindolylmaleimide and protein kinase A H-89. Furthermore, this inhibition was associated with reduction in N-type Ca2+ channel activity in the absence of any detectable change in cAMP levels. In the presence of forskolin, however, L-AP4 decreased the levels of cAMP. The activation of this additional signaling pathway was very efficient in counteracting the facilitation of glutamate release induced either by forskolin or the β-adrenergic receptor agonist isoproterenol. Imaging experiments to measure Ca2+ dynamics in single nerve terminals showed that L-AP4 strongly reduced the Ca2+ response in 28% of the nerve terminals. Moreover, immunochemical experiments showed that 25-35% of the nerve terminals that were immunopositive to synaptophysin were also immunoreactive to the low affinity L-AP4-sensitive mGluR7. Then, mGluR7 mediates the inhibition of glutamate release caused by 1 mM L-AP4, primarily by a strong inhibition of Ca2+ channels, although high cAMP uncovers the receptor ability to decrease cAMP. acknowledgement: We thank Dr. Enrique Castro from Las Palmas University for critical reading of the manuscript and M. Sefton for editorial assistance. article_processing_charge: No article_type: original author: - first_name: Carmelo full_name: Millán, Carmelo last_name: Millán - first_name: Rafael full_name: Luján, Rafael last_name: Luján - first_name: Ryuichi full_name: Shigemoto, Ryuichi id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 - first_name: José full_name: Sánchez Prieto, José last_name: Sánchez Prieto citation: ama: Millán C, Luján R, Shigemoto R, Sánchez Prieto J. The inhibition of glutamate release by metabotropic glutamate receptor 7 affects both [Ca2+]c and cAMP. Evidence for a strong reduction of Ca2+ entry in single nerve terminals. Journal of Biological Chemistry. 2002;277(16):14092-14101. doi:10.1074/jbc.M109044200 apa: Millán, C., Luján, R., Shigemoto, R., & Sánchez Prieto, J. (2002). The inhibition of glutamate release by metabotropic glutamate receptor 7 affects both [Ca2+]c and cAMP. Evidence for a strong reduction of Ca2+ entry in single nerve terminals. Journal of Biological Chemistry. American Society for Biochemistry and Molecular Biology. https://doi.org/10.1074/jbc.M109044200 chicago: Millán, Carmelo, Rafael Luján, Ryuichi Shigemoto, and José Sánchez Prieto. “The Inhibition of Glutamate Release by Metabotropic Glutamate Receptor 7 Affects Both [Ca2+]c and CAMP. Evidence for a Strong Reduction of Ca2+ Entry in Single Nerve Terminals.” Journal of Biological Chemistry. American Society for Biochemistry and Molecular Biology, 2002. https://doi.org/10.1074/jbc.M109044200. ieee: C. Millán, R. Luján, R. Shigemoto, and J. Sánchez Prieto, “The inhibition of glutamate release by metabotropic glutamate receptor 7 affects both [Ca2+]c and cAMP. Evidence for a strong reduction of Ca2+ entry in single nerve terminals,” Journal of Biological Chemistry, vol. 277, no. 16. American Society for Biochemistry and Molecular Biology, pp. 14092–14101, 2002. ista: Millán C, Luján R, Shigemoto R, Sánchez Prieto J. 2002. The inhibition of glutamate release by metabotropic glutamate receptor 7 affects both [Ca2+]c and cAMP. Evidence for a strong reduction of Ca2+ entry in single nerve terminals. Journal of Biological Chemistry. 277(16), 14092–14101. mla: Millán, Carmelo, et al. “The Inhibition of Glutamate Release by Metabotropic Glutamate Receptor 7 Affects Both [Ca2+]c and CAMP. Evidence for a Strong Reduction of Ca2+ Entry in Single Nerve Terminals.” Journal of Biological Chemistry, vol. 277, no. 16, American Society for Biochemistry and Molecular Biology, 2002, pp. 14092–101, doi:10.1074/jbc.M109044200. short: C. Millán, R. Luján, R. Shigemoto, J. Sánchez Prieto, Journal of Biological Chemistry 277 (2002) 14092–14101. date_created: 2018-12-11T11:58:41Z date_published: 2002-04-19T00:00:00Z date_updated: 2023-07-25T10:16:44Z day: '19' ddc: - '570' doi: 10.1074/jbc.M109044200 extern: '1' external_id: pmid: - '11825890' file: - access_level: open_access checksum: 0290fcbbd9153ec654185b0c856f214c content_type: application/pdf creator: alisjak date_created: 2023-07-25T10:13:16Z date_updated: 2023-07-25T10:13:16Z file_id: '13309' file_name: 2002_JBC_Millan.pdf file_size: 2105520 relation: main_file success: 1 file_date_updated: 2023-07-25T10:13:16Z has_accepted_license: '1' intvolume: ' 277' issue: '16' language: - iso: eng month: '04' oa: 1 oa_version: Published Version page: 14092 - 14101 pmid: 1 publication: Journal of Biological Chemistry publication_identifier: issn: - 0021-9258 publication_status: published publisher: American Society for Biochemistry and Molecular Biology publist_id: '4284' quality_controlled: '1' scopus_import: '1' status: public title: The inhibition of glutamate release by metabotropic glutamate receptor 7 affects both [Ca2+]c and cAMP. Evidence for a strong reduction of Ca2+ entry in single nerve terminals tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 277 year: '2002' ... --- _id: '2613' abstract: - lang: eng text: In this investigation, we report identification and characterization of a 95 kDa postsynaptic density protein (PSD-95)/discs-large/ ZO-1 (PDZ) domain-containing protein termed tamalin, also recently named GRP1-associated scaffold protein (GRASP), that interacts with group 1 metabotropic glutamate receptors (mGluRs). The yeast two-hybrid system and in vitro pull-down assays indicated that the PDZ domain-containing, amino-terminal half of tamalin directly binds to the class I PDZ-binding motif of group 1 mGluRs. The C-terminal half of tamalin also bound to cytohesins, the members of guanine nucleotide exchange factors (GEFs) specific for the ADP-ribosylation factor (ARF) family of small GTP-binding proteins. Tamalin mRNA is expressed predominantly in the telencephalic region and highly overlaps with the expression of group 1 mGluR mRNAs. Both tamalin and cytohesin-2 were enriched and codistributed with mGluR1a in postsynaptic membrane fractions. Importantly, recombinant and native mGluR1a/tamalin/cytohesin-2 complexes were coimmunoprecipitated from transfected COS-7 cells and rat brain tissue, respectively. Transfection of tamalin and mutant tamalin lacking a cytohesin-binding domain caused an increase and decrease in cell-surface expression of mGluR1a in COS-7 cells, respectively. Furthermore, adenovirus-mediated expression of tamalin and dominant-negative tamalin facilitated and reduced the neuritic distribution of endogenous mGluR5 in cultured hippocampal neurons, respectively. The results indicate that tamalin plays a key role in the association of group 1 mGluRs with the ARF-specific GEF proteins and contributes to intracellular trafficking and the macromolecular organization of group 1 mGluRs at synapses. acknowledgement: This work was supported in part by research grants from the Ministry of Education, Science and Culture of Japan. We thank Bert Vogelstein for providing adenoviral recombination vectors and Haruhiko Bito for a gift of the enolase promoter and technical advice. We are grateful to Atsushi Nishimune and Satoshi Kaneko for technical advice and Kumlesh K. Dev for careful reading of this manuscript. article_processing_charge: No article_type: original author: - first_name: Jun full_name: Kitano, Jun last_name: Kitano - first_name: Kouji full_name: Kimura, Kouji last_name: Kimura - first_name: Yoshimitsu full_name: Yamazaki, Yoshimitsu last_name: Yamazaki - first_name: Takeshi full_name: Soda, Takeshi last_name: Soda - first_name: Ryuichi full_name: Shigemoto, Ryuichi id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 - first_name: Yoshiaki full_name: Nakajima, Yoshiaki last_name: Nakajima - first_name: Shigetada full_name: Nakanishi, Shigetada last_name: Nakanishi citation: ama: Kitano J, Kimura K, Yamazaki Y, et al. Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins. Journal of Neuroscience. 2002;22(4):1280-1289. doi:10.1523/JNEUROSCI.22-04-01280.2002 apa: Kitano, J., Kimura, K., Yamazaki, Y., Soda, T., Shigemoto, R., Nakajima, Y., & Nakanishi, S. (2002). Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.22-04-01280.2002 chicago: Kitano, Jun, Kouji Kimura, Yoshimitsu Yamazaki, Takeshi Soda, Ryuichi Shigemoto, Yoshiaki Nakajima, and Shigetada Nakanishi. “Tamalin, a PDZ Domain-Containing Protein, Links a Protein Complex Formation of Group 1 Metabotropic Glutamate Receptors and the Guanine Nucleotide Exchange Factor Cytohesins.” Journal of Neuroscience. Society for Neuroscience, 2002. https://doi.org/10.1523/JNEUROSCI.22-04-01280.2002. ieee: J. Kitano et al., “Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins,” Journal of Neuroscience, vol. 22, no. 4. Society for Neuroscience, pp. 1280–1289, 2002. ista: Kitano J, Kimura K, Yamazaki Y, Soda T, Shigemoto R, Nakajima Y, Nakanishi S. 2002. Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins. Journal of Neuroscience. 22(4), 1280–1289. mla: Kitano, Jun, et al. “Tamalin, a PDZ Domain-Containing Protein, Links a Protein Complex Formation of Group 1 Metabotropic Glutamate Receptors and the Guanine Nucleotide Exchange Factor Cytohesins.” Journal of Neuroscience, vol. 22, no. 4, Society for Neuroscience, 2002, pp. 1280–89, doi:10.1523/JNEUROSCI.22-04-01280.2002. short: J. Kitano, K. Kimura, Y. Yamazaki, T. Soda, R. Shigemoto, Y. Nakajima, S. Nakanishi, Journal of Neuroscience 22 (2002) 1280–1289. date_created: 2018-12-11T11:58:40Z date_published: 2002-02-15T00:00:00Z date_updated: 2023-07-25T11:34:46Z day: '15' doi: 10.1523/JNEUROSCI.22-04-01280.2002 extern: '1' external_id: pmid: - '11850456' intvolume: ' 22' issue: '4' language: - iso: eng month: '02' oa_version: None page: 1280 - 1289 pmid: 1 publication: Journal of Neuroscience publication_identifier: issn: - 0270-6474 publication_status: published publisher: Society for Neuroscience publist_id: '4285' quality_controlled: '1' scopus_import: '1' status: public title: Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 22 year: '2002' ... --- _id: '2616' abstract: - lang: eng text: Neurons in the rat cerebral cortex are enriched in group I metabotropic glutamate receptor (mGluR) subtypes and respond to their activation during development. To understand better the mechanisms by which mGluR1 and mGluR5 mediate these effects, the goal of this study was to elucidate the expression pattern and to determine the cellular and the precise subcellular localization of these two receptor subtypes in the rat neocortex and hippocampus during late prenatal and postnatal development. At the light microscopic level, mGluR1 α and mGluR5 were first detected in the cerebral cortex with different expression levels at embryonic day E18. Thus, mGluR5 had a moderate expression, whereas mGluR1 α was detected as a diffuse and weak labeling. mGluR5 was localized in some Cajal-Retzius cells as well as in other cell types, such as pioneer neurons of the marginal zone. During postnatal development, the distribution of the receptors dramatically changed. From P0 to around P10, mGluR1α was localized in identified, transient Cajal-Retzius cells of neocortex and hippocampus, until these cells disappear. In addition, a population of interneurons localized the receptor from the second/third postnatal week. In contrast, mGluR5 was localized mainly in pyramidal cells and in some interneurons, with a neuropilar staining throughout the cerebral cortex. At the electron microscopic level, the immunoreactivity for both group I mGluR subtypes was expressed postsynaptically. Using immunogold methods, mGluR1α and mGluR5 immunoreactivities were found throughout postnatal development at the edge of postsynaptic specialization of asymmetrical synapses. These results show that the two group I mGluRs have a differential expression pattern in neocortex and hippocampus that may suggest roles for the receptors in the early processing of cortical information and in the control of cortical developmental events. acknowledgement: The authors are grateful to Dr Ole Paulsen and Professor Kay Davies for their comments on the manuscript. We also would like to thank Dr Zoltan Molnar for his support and Mrs Lucy Jones, Ms Courtney Voelker and Mr David Dongworth for the English revision of the manuscript. This work was supported by grants from the European Community (QLG3-CT-1999-00192 to R.L.) and the Spanish Ministerio de Ciencia y Tecnología (PB97-0582-CO2-01 to A.F.). article_processing_charge: No article_type: original author: - first_name: Guillermina full_name: López Bendito, Guillermina last_name: López Bendito - first_name: Ryuichi full_name: Shigemoto, Ryuichi id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 - first_name: Alfonso full_name: Fairén, Alfonso last_name: Fairén - first_name: Rafael full_name: Luján, Rafael last_name: Luján citation: ama: López Bendito G, Shigemoto R, Fairén A, Luján R. Differential distribution of group I metabotropic glutamate receptors during rat cortical development. Cerebral Cortex. 2002;12(6):625-638. doi:10.1093/cercor/12.6.625 apa: López Bendito, G., Shigemoto, R., Fairén, A., & Luján, R. (2002). Differential distribution of group I metabotropic glutamate receptors during rat cortical development. Cerebral Cortex. Oxford University Press. https://doi.org/10.1093/cercor/12.6.625 chicago: López Bendito, Guillermina, Ryuichi Shigemoto, Alfonso Fairén, and Rafael Luján. “Differential Distribution of Group I Metabotropic Glutamate Receptors during Rat Cortical Development.” Cerebral Cortex. Oxford University Press, 2002. https://doi.org/10.1093/cercor/12.6.625. ieee: G. López Bendito, R. Shigemoto, A. Fairén, and R. Luján, “Differential distribution of group I metabotropic glutamate receptors during rat cortical development,” Cerebral Cortex, vol. 12, no. 6. Oxford University Press, pp. 625–638, 2002. ista: López Bendito G, Shigemoto R, Fairén A, Luján R. 2002. Differential distribution of group I metabotropic glutamate receptors during rat cortical development. Cerebral Cortex. 12(6), 625–638. mla: López Bendito, Guillermina, et al. “Differential Distribution of Group I Metabotropic Glutamate Receptors during Rat Cortical Development.” Cerebral Cortex, vol. 12, no. 6, Oxford University Press, 2002, pp. 625–38, doi:10.1093/cercor/12.6.625. short: G. López Bendito, R. Shigemoto, A. Fairén, R. Luján, Cerebral Cortex 12 (2002) 625–638. date_created: 2018-12-11T11:58:41Z date_published: 2002-06-01T00:00:00Z date_updated: 2023-07-25T09:54:10Z day: '01' doi: 10.1093/cercor/12.6.625 extern: '1' external_id: pmid: - '12003862' intvolume: ' 12' issue: '6' language: - iso: eng month: '06' oa_version: None page: 625 - 638 pmid: 1 publication: Cerebral Cortex publication_identifier: issn: - 1047-3211 publication_status: published publisher: Oxford University Press publist_id: '4282' quality_controlled: '1' scopus_import: '1' status: public title: Differential distribution of group I metabotropic glutamate receptors during rat cortical development type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 12 year: '2002' ... --- _id: '2619' abstract: - lang: eng text: The release of glutamate and GABA is modulated by presynaptic metabotropic glutamate receptors (mGluRs). We used immunocytochemical methods to define the location of the group III receptor mGluR7a in glutamatergic and GABAergic terminals innervating GABAergic interneurons and pyramidal cells. Immunoreactivity for mGluR7a was localized in the presynaptic active zone of both identified GABAergic and presumed glutamatergic terminals. Terminals innervating dendritic spines showed a variable level of receptor immunoreactivity, ranging from immunonegative to strongly immunopositive. The frequency of strongly mGluR7a positive terminals innervating the soma and dendrites of mGluR1α/somatostatin-expressing interneurons was very high relative to other neurons. On dendrites that received mGluR7a-enriched glutamatergic innervation, at least 80% of GABAergic terminals were immunopositive for mGluR7a. On such dendrites virtually all (95%) vasoactive intestinal polypeptide (VIP) positive (GABAergic) terminals were enriched in mGluR7a. The targets of VIP/mGluR7a-expressing terminals were mainly (88%) mGluR1α-expressing interneurons, which were mostly somatostatin immunopositive. Parvalbumin positive terminals were immunonegative for mGluR7a. Some parvalbumin immunoreactive dendrites received strongly mGluR7a positive terminals. The subcellular location, as well as the cell type and synapse-specific distribution of mGluR7a in isocortical neuronal circuits, is homologous to its distribution in the hippocampus. The specific location of mGluR7a in the presynaptic active zone of both glutamatergic and GABAergic synapses may be related to the proximity of calcium channels and the vesicle fusion machinery. The enrichment of mGluR7a in the main GABAergic, as well as in the glutamatergic, innervation of mGluR1α/somatostatin-expressing interneurons suggests that their activation is under unique regulation by extracellular glutamate. acknowledgement: We thank Dr C. Paspalas for an initial contribution to the immunocytochemistry. We are grateful for the generous gifts of antibodies from Dr A. Buchan (anti-somatostatin, Department of Physiology, University of British Columbia, Canada), Dr M. Watanabe (anti-mGluR1α, Department of Anatomy, Hokkaido University School of Medicine, Sapporo) and Dr K. Tanaka (anti-GAD, Niigata University, Faculty of Medicine, Department of Neurology). We thank Dr F. Ferraguti for helpful suggestions during the project and for his comments on a previous version of the manuscript. We also thank Philip Cobden, Paul Jays and Laszlo Marton for assistance. Y.D. was supported by a Wellcome Trust Advanced Training Fellowship. article_processing_charge: No article_type: original author: - first_name: Yannis full_name: Dalezios, Yannis last_name: Dalezios - first_name: Rafael full_name: Luján, Rafael last_name: Luján - first_name: Ryuichi full_name: Shigemoto, Ryuichi id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 - first_name: John full_name: Roberts, John last_name: Roberts - first_name: Péter full_name: Somogyi, Péter last_name: Somogyi citation: ama: Dalezios Y, Luján R, Shigemoto R, Roberts J, Somogyi P. Enrichment of mGluR7a in the Presynaptic active zones of GABAergic and Non-GABAergic terminals on interneurons in the rat somatosensory cortex. Cerebral Cortex. 2002;12(9):961-974. doi:10.1093/cercor/12.9.961 apa: Dalezios, Y., Luján, R., Shigemoto, R., Roberts, J., & Somogyi, P. (2002). Enrichment of mGluR7a in the Presynaptic active zones of GABAergic and Non-GABAergic terminals on interneurons in the rat somatosensory cortex. Cerebral Cortex. Oxford University Press. https://doi.org/10.1093/cercor/12.9.961 chicago: Dalezios, Yannis, Rafael Luján, Ryuichi Shigemoto, John Roberts, and Péter Somogyi. “Enrichment of MGluR7a in the Presynaptic Active Zones of GABAergic and Non-GABAergic Terminals on Interneurons in the Rat Somatosensory Cortex.” Cerebral Cortex. Oxford University Press, 2002. https://doi.org/10.1093/cercor/12.9.961. ieee: Y. Dalezios, R. Luján, R. Shigemoto, J. Roberts, and P. Somogyi, “Enrichment of mGluR7a in the Presynaptic active zones of GABAergic and Non-GABAergic terminals on interneurons in the rat somatosensory cortex,” Cerebral Cortex, vol. 12, no. 9. Oxford University Press, pp. 961–974, 2002. ista: Dalezios Y, Luján R, Shigemoto R, Roberts J, Somogyi P. 2002. Enrichment of mGluR7a in the Presynaptic active zones of GABAergic and Non-GABAergic terminals on interneurons in the rat somatosensory cortex. Cerebral Cortex. 12(9), 961–974. mla: Dalezios, Yannis, et al. “Enrichment of MGluR7a in the Presynaptic Active Zones of GABAergic and Non-GABAergic Terminals on Interneurons in the Rat Somatosensory Cortex.” Cerebral Cortex, vol. 12, no. 9, Oxford University Press, 2002, pp. 961–74, doi:10.1093/cercor/12.9.961. short: Y. Dalezios, R. Luján, R. Shigemoto, J. Roberts, P. Somogyi, Cerebral Cortex 12 (2002) 961–974. date_created: 2018-12-11T11:58:42Z date_published: 2002-09-01T00:00:00Z date_updated: 2023-07-25T09:40:49Z day: '01' doi: 10.1093/cercor/12.9.961 extern: '1' external_id: pmid: - '12183395' intvolume: ' 12' issue: '9' language: - iso: eng month: '09' oa_version: None page: 961 - 974 pmid: 1 publication: Cerebral Cortex publication_identifier: issn: - 1047-3211 publication_status: published publisher: Oxford University Press publist_id: '4280' quality_controlled: '1' scopus_import: '1' status: public title: Enrichment of mGluR7a in the Presynaptic active zones of GABAergic and Non-GABAergic terminals on interneurons in the rat somatosensory cortex type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 12 year: '2002' ... --- _id: '2615' abstract: - lang: eng text: Taste-mGluR4, cloned from taste tissues, is a truncated variant of brain-expressed mGluR4a (brain-mGluR4), and is known to be a candidate for the receptor involved in the umami taste sense. Although the expression patterns of taste- and brain-mGluR4 mRNAs have been demonstrated, no mention has so far been made of the expression of these two mGluR4 proteins in taste tissues. The present study examined the expression of taste-mGluR4 and brain-mGluR4 proteins in rat taste tissues by using a specific antibody for mGluR4a which shared a C-terminus of both taste- and brain-mGluR4, for immunoblot analysis and immunohistochemistry. Immunoblot analysis showed that both brain-mGluR4 and taste-mGluR4 were expressed in the taste tissues. Taste-mGluR4 was not detected in the cerebellum. The immunoreactive band for brain-mGluR4 protein was much stronger than that for taste-mGluR4 protein. In the cryosections of fungiform, foliate and circumvallate papillae, the antibody against taste-mGluR4 exhibited intense labeling of the taste pores and taste hairs in all the taste buds of gustatory papillae examined; the immunoreaction to the antibody against brain-mGluR4 was more intense at the same sites of the taste buds. The portions of the taste bud cells below the taste pore and surrounding keratinocytes did not show any immunoreactivities. The results of the present study strongly suggest that, in addition to taste-mGluR4, brain-mGluR4 may function even more importantly than the former as a receptor for glutamate, i.e. the umami taste sensation. article_processing_charge: No article_type: original author: - first_name: Takashi full_name: Toyono, Takashi last_name: Toyono - first_name: Yuji full_name: Seta, Yuji last_name: Seta - first_name: Shinji full_name: Sataoka, Shinji last_name: Sataoka - first_name: Harumi full_name: Harada, Harumi id: 2E55CDF2-F248-11E8-B48F-1D18A9856A87 last_name: Harada orcid: 0000-0001-7429-7896 - first_name: Takahiko full_name: Morotomi, Takahiko last_name: Morotomi - first_name: Shintaro full_name: Kawano, Shintaro last_name: Kawano - first_name: Ryuichi full_name: Shigemoto, Ryuichi id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 - first_name: Kuniaki full_name: Toyoshima, Kuniaki last_name: Toyoshima citation: ama: Toyono T, Seta Y, Sataoka S, et al. Expression of the metabotropic glutamate receptor, mGluR4a, in the taste hairs of taste buds in rat gustatory papillae. Archives of Histology and Cytology. 2002;65(1):91-96. doi:10.1679/aohc.65.91 apa: Toyono, T., Seta, Y., Sataoka, S., Harada, H., Morotomi, T., Kawano, S., … Toyoshima, K. (2002). Expression of the metabotropic glutamate receptor, mGluR4a, in the taste hairs of taste buds in rat gustatory papillae. Archives of Histology and Cytology. Japan Society of Histological Documentation. https://doi.org/10.1679/aohc.65.91 chicago: Toyono, Takashi, Yuji Seta, Shinji Sataoka, Harumi Harada, Takahiko Morotomi, Shintaro Kawano, Ryuichi Shigemoto, and Kuniaki Toyoshima. “Expression of the Metabotropic Glutamate Receptor, MGluR4a, in the Taste Hairs of Taste Buds in Rat Gustatory Papillae.” Archives of Histology and Cytology. Japan Society of Histological Documentation, 2002. https://doi.org/10.1679/aohc.65.91. ieee: T. Toyono et al., “Expression of the metabotropic glutamate receptor, mGluR4a, in the taste hairs of taste buds in rat gustatory papillae,” Archives of Histology and Cytology, vol. 65, no. 1. Japan Society of Histological Documentation, pp. 91–96, 2002. ista: Toyono T, Seta Y, Sataoka S, Harada H, Morotomi T, Kawano S, Shigemoto R, Toyoshima K. 2002. Expression of the metabotropic glutamate receptor, mGluR4a, in the taste hairs of taste buds in rat gustatory papillae. Archives of Histology and Cytology. 65(1), 91–96. mla: Toyono, Takashi, et al. “Expression of the Metabotropic Glutamate Receptor, MGluR4a, in the Taste Hairs of Taste Buds in Rat Gustatory Papillae.” Archives of Histology and Cytology, vol. 65, no. 1, Japan Society of Histological Documentation, 2002, pp. 91–96, doi:10.1679/aohc.65.91. short: T. Toyono, Y. Seta, S. Sataoka, H. Harada, T. Morotomi, S. Kawano, R. Shigemoto, K. Toyoshima, Archives of Histology and Cytology 65 (2002) 91–96. date_created: 2018-12-11T11:58:41Z date_published: 2002-01-01T00:00:00Z date_updated: 2023-07-25T10:00:15Z day: '01' doi: 10.1679/aohc.65.91 extern: '1' external_id: pmid: - '12002614' intvolume: ' 65' issue: '1' language: - iso: eng month: '01' oa_version: None page: 91 - 96 pmid: 1 publication: Archives of Histology and Cytology publication_identifier: issn: - 0914-9465 publication_status: published publisher: Japan Society of Histological Documentation publist_id: '4283' quality_controlled: '1' scopus_import: '1' status: public title: Expression of the metabotropic glutamate receptor, mGluR4a, in the taste hairs of taste buds in rat gustatory papillae type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 65 year: '2002' ... --- _id: '2618' abstract: - lang: eng text: The unipolar brush cell (UBC) is a type of glutamatergic interneuron in the granular layer of the cerebellum. The UBC brush and a single mossy fiber (MF) terminal contact each other within a cerebellar glomerulus, forming a giant synapse. Many UBCs receive input from extrinsic MFs, whereas others are innervated by intrinsic mossy terminals formed by the axons of other UBCs. In all mammalian species so far examined, the vestibulocerebellum is enriched of UBCs that are strongly immunoreactive for the calcium binding protein calretinin (CR) in both the somatodendritic and axonal compartment. UBCs have postsynaptic ionotropic glutamate receptors and extrasynaptic metabotropic glutamate receptors that immunocytochemically highlight their somatodendritic compartment and brush, respectively. In this study on the mouse cerebellum, we present evidence that immunoreactivities to CR and mGluR1α define two distinct UBC subsets with partly overlapping distributions in lobule X (the nodulus). In sections double-labeled for CR and mGluR1α, the patterns of distributions of CR+/mGluR1α- UBCs and CR-/mGluR1α+ UBCs differed along the mediolateral and dorsoventral axes of the folium. Moreover, mGluR1α+ UBCs outnumbered CR+ UBCs. Both UBC subsets were mGluR2/3, GluR2/3, and NMDAR1 immunoreactive. The different distribution patterns of the two UBC subsets within lobule X suggest that expression of CR or mGluR1α by UBCs may be afferent-specific and related to the terminal fields of different vestibular MF afferents. article_processing_charge: No article_type: original author: - first_name: Maria full_name: Nunzi, Maria last_name: Nunzi - first_name: Ryuichi full_name: Shigemoto, Ryuichi id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 - first_name: Enrico full_name: Mugnaini, Enrico last_name: Mugnaini citation: ama: Nunzi M, Shigemoto R, Mugnaini E. Differential expression of calretinin and metabotropic glutamate receptor mGluR1α defines subsets of unipolar brush cells in mouse cerebellum. Journal of Comparative Neurology. 2002;451(2):189-199. doi:10.1002/cne.10344 apa: Nunzi, M., Shigemoto, R., & Mugnaini, E. (2002). Differential expression of calretinin and metabotropic glutamate receptor mGluR1α defines subsets of unipolar brush cells in mouse cerebellum. Journal of Comparative Neurology. Wiley-Blackwell. https://doi.org/10.1002/cne.10344 chicago: Nunzi, Maria, Ryuichi Shigemoto, and Enrico Mugnaini. “Differential Expression of Calretinin and Metabotropic Glutamate Receptor MGluR1α Defines Subsets of Unipolar Brush Cells in Mouse Cerebellum.” Journal of Comparative Neurology. Wiley-Blackwell, 2002. https://doi.org/10.1002/cne.10344. ieee: M. Nunzi, R. Shigemoto, and E. Mugnaini, “Differential expression of calretinin and metabotropic glutamate receptor mGluR1α defines subsets of unipolar brush cells in mouse cerebellum,” Journal of Comparative Neurology, vol. 451, no. 2. Wiley-Blackwell, pp. 189–199, 2002. ista: Nunzi M, Shigemoto R, Mugnaini E. 2002. Differential expression of calretinin and metabotropic glutamate receptor mGluR1α defines subsets of unipolar brush cells in mouse cerebellum. Journal of Comparative Neurology. 451(2), 189–199. mla: Nunzi, Maria, et al. “Differential Expression of Calretinin and Metabotropic Glutamate Receptor MGluR1α Defines Subsets of Unipolar Brush Cells in Mouse Cerebellum.” Journal of Comparative Neurology, vol. 451, no. 2, Wiley-Blackwell, 2002, pp. 189–99, doi:10.1002/cne.10344. short: M. Nunzi, R. Shigemoto, E. Mugnaini, Journal of Comparative Neurology 451 (2002) 189–199. date_created: 2018-12-11T11:58:42Z date_published: 2002-09-16T00:00:00Z date_updated: 2023-07-25T09:09:48Z day: '16' doi: 10.1002/cne.10344 extern: '1' external_id: pmid: - '12209836' intvolume: ' 451' issue: '2' language: - iso: eng month: '09' oa_version: None page: 189 - 199 pmid: 1 publication: Journal of Comparative Neurology publication_identifier: issn: - 0021-9967 publication_status: published publisher: Wiley-Blackwell publist_id: '4279' quality_controlled: '1' scopus_import: '1' status: public title: Differential expression of calretinin and metabotropic glutamate receptor mGluR1α defines subsets of unipolar brush cells in mouse cerebellum type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 451 year: '2002' ... --- _id: '2421' abstract: - lang: eng text: Intersection graphs of disks and of line segments, respectively, have been well studied, because of both, practical applications and theoretically interesting properties of these graphs. Despite partial results, the complexity status of the Clique problem for these two graph classes is still open. Here, we consider the Clique problem for intersection graphs of ellipses which in a sense, interpolate between disc and ellipses, and show that it is APX-hard in that case. Moreover, this holds even if for all ellipses, the ratio of the larger over the smaller radius is some prescribed number. To our knowledge, this is the first hardness result for the Clique problem in intersection graphs of objects with finite description complexity. We also describe a simple approximation algorithm for the case of ellipses for which the ratio of radii is bounded. alternative_title: - LNCS article_processing_charge: No author: - first_name: Christoph full_name: Ambühl, Christoph last_name: Ambühl - first_name: Uli full_name: Wagner, Uli id: 36690CA2-F248-11E8-B48F-1D18A9856A87 last_name: Wagner orcid: 0000-0002-1494-0568 citation: ama: 'Ambühl C, Wagner U. On the Clique problem in intersection graphs of ellipses. In: Proceedings of the 13th International Symposium on Algorithms and Computation. Vol 2518. Springer; 2002:489-500. doi:10.1007/3-540-36136-7_43' apa: 'Ambühl, C., & Wagner, U. (2002). On the Clique problem in intersection graphs of ellipses. In Proceedings of the 13th International Symposium on Algorithms and Computation (Vol. 2518, pp. 489–500). Vancouver, Canada: Springer. https://doi.org/10.1007/3-540-36136-7_43' chicago: Ambühl, Christoph, and Uli Wagner. “On the Clique Problem in Intersection Graphs of Ellipses.” In Proceedings of the 13th International Symposium on Algorithms and Computation, 2518:489–500. Springer, 2002. https://doi.org/10.1007/3-540-36136-7_43. ieee: C. Ambühl and U. Wagner, “On the Clique problem in intersection graphs of ellipses,” in Proceedings of the 13th International Symposium on Algorithms and Computation, Vancouver, Canada, 2002, vol. 2518, pp. 489–500. ista: 'Ambühl C, Wagner U. 2002. On the Clique problem in intersection graphs of ellipses. Proceedings of the 13th International Symposium on Algorithms and Computation. ISAAC: International Symposium on Algorithms and Computation, LNCS, vol. 2518, 489–500.' mla: Ambühl, Christoph, and Uli Wagner. “On the Clique Problem in Intersection Graphs of Ellipses.” Proceedings of the 13th International Symposium on Algorithms and Computation, vol. 2518, Springer, 2002, pp. 489–500, doi:10.1007/3-540-36136-7_43. short: C. Ambühl, U. Wagner, in:, Proceedings of the 13th International Symposium on Algorithms and Computation, Springer, 2002, pp. 489–500. conference: end_date: 2002-11-23 location: Vancouver, Canada name: 'ISAAC: International Symposium on Algorithms and Computation' start_date: 2002-11-21 date_created: 2018-12-11T11:57:34Z date_published: 2002-01-01T00:00:00Z date_updated: 2023-07-25T11:48:36Z day: '01' doi: 10.1007/3-540-36136-7_43 extern: '1' intvolume: ' 2518' language: - iso: eng month: '01' oa_version: None page: 489 - 500 publication: Proceedings of the 13th International Symposium on Algorithms and Computation publication_identifier: isbn: - '9783540001423' publication_status: published publisher: Springer publist_id: '4504' quality_controlled: '1' scopus_import: '1' status: public title: On the Clique problem in intersection graphs of ellipses type: conference user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 2518 year: '2002' ... --- _id: '2353' abstract: - lang: eng text: A commonly used theoretical definition of superfluidity in the ground state of a Bose gas is based on the response of the system to an imposed velocity field or, equivalently, to twisted boundary conditions in a box. We are able to carry out this program in the case of a dilute interacting Bose gas in a trap, and we prove that a gas with repulsive interactions is 100% superfluid in the dilute limit in which the Gross-Pitaevskii equation is exact. This is the first example in an experimentally realistic continuum model in which superfluidity is rigorously verified. acknowledgement: E.H.L. was partially supported by the U.S. National Science Foundation, Grant No. PHY 98-20650. R.S. was supported by the Austrian Science Fund in the from of an Erwin Schrödinger fellowship. article_processing_charge: No article_type: original author: - first_name: Élliott full_name: Lieb, Élliott last_name: Lieb - first_name: Robert full_name: Seiringer, Robert id: 4AFD0470-F248-11E8-B48F-1D18A9856A87 last_name: Seiringer orcid: 0000-0002-6781-0521 - first_name: Jakob full_name: Yngvason, Jakob last_name: Yngvason citation: ama: Lieb É, Seiringer R, Yngvason J. Superfluidity in dilute trapped Bose gases. Physical Review B - Condensed Matter and Materials Physics. 2002;66(13). doi:10.1103/PhysRevB.66.134529 apa: Lieb, É., Seiringer, R., & Yngvason, J. (2002). Superfluidity in dilute trapped Bose gases. Physical Review B - Condensed Matter and Materials Physics. American Physical Society. https://doi.org/10.1103/PhysRevB.66.134529 chicago: Lieb, Élliott, Robert Seiringer, and Jakob Yngvason. “Superfluidity in Dilute Trapped Bose Gases.” Physical Review B - Condensed Matter and Materials Physics. American Physical Society, 2002. https://doi.org/10.1103/PhysRevB.66.134529. ieee: É. Lieb, R. Seiringer, and J. Yngvason, “Superfluidity in dilute trapped Bose gases,” Physical Review B - Condensed Matter and Materials Physics, vol. 66, no. 13. American Physical Society, 2002. ista: Lieb É, Seiringer R, Yngvason J. 2002. Superfluidity in dilute trapped Bose gases. Physical Review B - Condensed Matter and Materials Physics. 66(13). mla: Lieb, Élliott, et al. “Superfluidity in Dilute Trapped Bose Gases.” Physical Review B - Condensed Matter and Materials Physics, vol. 66, no. 13, American Physical Society, 2002, doi:10.1103/PhysRevB.66.134529. short: É. Lieb, R. Seiringer, J. Yngvason, Physical Review B - Condensed Matter and Materials Physics 66 (2002). date_created: 2018-12-11T11:57:10Z date_published: 2002-10-01T00:00:00Z date_updated: 2023-07-25T12:05:47Z day: '01' doi: 10.1103/PhysRevB.66.134529 extern: '1' external_id: arxiv: - cond-mat/0205570 intvolume: ' 66' issue: '13' language: - iso: eng main_file_link: - open_access: '1' url: http://arxiv.org/abs/cond-mat/0205570 month: '10' oa: 1 oa_version: None publication: Physical Review B - Condensed Matter and Materials Physics publication_identifier: issn: - 0163-1829 publication_status: published publisher: American Physical Society publist_id: '4573' quality_controlled: '1' scopus_import: '1' status: public title: Superfluidity in dilute trapped Bose gases type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 66 year: '2002' ... --- _id: '2420' abstract: - lang: eng text: 'A corner cut in dimension d is a finite subset of N0d that can be separated from its complement in N0d by an affine hyperplane disjoint from N0d. Corner cuts were first investigated by Onn and Sturmfels [Adv. Appl. Math. 23 (1999) 29-48], their original motivation stemmed from computational commutative algebra. Let us write (Nd0k)cut for the set of corner cuts of cardinality k; in the computational geometer''s terminology, these are the k-sets of N0d. Among other things, Onn and Sturmfels give an upper bound of O(k2d(d-1)/(d+1)) for the size of (Nd0k)cut when the dimension is fixed. In two dimensions, it is known (see [Corteel et al., Adv. Appl. Math. 23 (1) (1999) 49-53]) that #(Nd0k)cut = Θ(k log k). We will see that in general, for any fixed dimension d, the order of magnitude of #(Nd0k)cut is between kd-1 log k and (k log k)d-1. (It has been communicated to me that the same bounds have been found independently by G. Rémond.) In fact, the elements of (Nd0k)cut correspond to the vertices of a certain polytope, and what our proof shows is that the above upper bound holds for the total number of flags of that polytope.' acknowledgement: "I first learned about corner cuts in a seminar talk in which Artur Andrzejak\r\npresented the results from [6]. My work was initiated by that presentation and\r\nby the discussions that followed it. I also thank Komei Fukuda, Ingo Schurr, and\r\nEmo Welzl for helpful comments and discussions." article_processing_charge: No article_type: original author: - first_name: Uli full_name: Wagner, Uli id: 36690CA2-F248-11E8-B48F-1D18A9856A87 last_name: Wagner orcid: 0000-0002-1494-0568 citation: ama: Wagner U. On the number of corner cuts. Advances in Applied Mathematics. 2002;29(2):152-161. doi:10.1016/S0196-8858(02)00014-3 apa: Wagner, U. (2002). On the number of corner cuts. Advances in Applied Mathematics. ACM. https://doi.org/10.1016/S0196-8858(02)00014-3 chicago: Wagner, Uli. “On the Number of Corner Cuts.” Advances in Applied Mathematics. ACM, 2002. https://doi.org/10.1016/S0196-8858(02)00014-3. ieee: U. Wagner, “On the number of corner cuts,” Advances in Applied Mathematics, vol. 29, no. 2. ACM, pp. 152–161, 2002. ista: Wagner U. 2002. On the number of corner cuts. Advances in Applied Mathematics. 29(2), 152–161. mla: Wagner, Uli. “On the Number of Corner Cuts.” Advances in Applied Mathematics, vol. 29, no. 2, ACM, 2002, pp. 152–61, doi:10.1016/S0196-8858(02)00014-3. short: U. Wagner, Advances in Applied Mathematics 29 (2002) 152–161. date_created: 2018-12-11T11:57:33Z date_published: 2002-08-01T00:00:00Z date_updated: 2023-07-25T11:55:42Z day: '01' doi: 10.1016/S0196-8858(02)00014-3 extern: '1' intvolume: ' 29' issue: '2' language: - iso: eng month: '08' oa_version: None page: 152 - 161 publication: Advances in Applied Mathematics publication_identifier: issn: - 0196-8858 publication_status: published publisher: ACM publist_id: '4505' quality_controlled: '1' scopus_import: '1' status: public title: On the number of corner cuts type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 29 year: '2002' ... --- _id: '2338' abstract: - lang: eng text: Now that the low temperature properties of quantum-mechanical many-body systems (bosons) at low density, ρ, can be examined experimentally it is appropriate to revisit some of the formulas deduced by many authors 4-5 decades ago. For systems with repulsive (i.e. positive) interaction potentials the experimental low temperature state and the ground state are effectively synonymous -- and this fact is used in all modeling. In such cases, the leading term in the energy/particle is 2πℏ2aρ/m where a is the scattering length of the two-body potential. Owing to the delicate and peculiar nature of bosonic correlations (such as the strange N7/5 law for charged bosons), four decades of research failed to establish this plausible formula rigorously. The only previous lower bound for the energy was found by Dyson in 1957, but it was 14 times too small. The correct asymptotic formula has recently been obtained by us and this work will be presented. The reason behind the mathematical difficulties will be emphasized. A different formula, postulated as late as 1971 by Schick, holds in two-dimensions and this, too, will be shown to be correct. With the aid of the methodology developed to prove the lower bound for the homogeneous gas, two other problems have been successfully addressed. One is the proof by us that the Gross-Pitaevskii equation correctly describes the ground state in the `traps' actually used in the experiments. For this system it is also possible to prove complete Bose condensation, as we have shown. Another topic is a proof that Foldy's 1961 theory of a high density Bose gas of charged particles correctly describes its ground state energy. alternative_title: - Current Developments in Mathematics article_processing_charge: No author: - first_name: Élliott full_name: Lieb, Élliott last_name: Lieb - first_name: Jan full_name: Solovej, Jan last_name: Solovej - first_name: Robert full_name: Seiringer, Robert id: 4AFD0470-F248-11E8-B48F-1D18A9856A87 last_name: Seiringer orcid: 0000-0002-6781-0521 - first_name: Jakob full_name: Yngvason, Jakob last_name: Yngvason citation: ama: 'Lieb É, Solovej J, Seiringer R, Yngvason J. The ground state of the Bose gas. In: Current Developments in Mathematics, 2001. International Press; 2002:131-178. doi:10.48550/arXiv.math-ph/0204027' apa: Lieb, É., Solovej, J., Seiringer, R., & Yngvason, J. (2002). The ground state of the Bose gas. In Current Developments in Mathematics, 2001 (pp. 131–178). International Press. https://doi.org/10.48550/arXiv.math-ph/0204027 chicago: Lieb, Élliott, Jan Solovej, Robert Seiringer, and Jakob Yngvason. “The Ground State of the Bose Gas.” In Current Developments in Mathematics, 2001, 131–78. International Press, 2002. https://doi.org/10.48550/arXiv.math-ph/0204027. ieee: É. Lieb, J. Solovej, R. Seiringer, and J. Yngvason, “The ground state of the Bose gas,” in Current Developments in Mathematics, 2001, International Press, 2002, pp. 131–178. ista: 'Lieb É, Solovej J, Seiringer R, Yngvason J. 2002.The ground state of the Bose gas. In: Current Developments in Mathematics, 2001. Current Developments in Mathematics, , 131–178.' mla: Lieb, Élliott, et al. “The Ground State of the Bose Gas.” Current Developments in Mathematics, 2001, International Press, 2002, pp. 131–78, doi:10.48550/arXiv.math-ph/0204027. short: É. Lieb, J. Solovej, R. Seiringer, J. Yngvason, in:, Current Developments in Mathematics, 2001, International Press, 2002, pp. 131–178. date_created: 2018-12-11T11:57:04Z date_published: 2002-01-01T00:00:00Z date_updated: 2023-07-26T08:43:46Z day: '01' doi: 10.48550/arXiv.math-ph/0204027 extern: '1' external_id: arxiv: - math-ph/0204027 language: - iso: eng main_file_link: - open_access: '1' url: http://arxiv.org/abs/math-ph/0204027 month: '01' oa: 1 oa_version: Published Version page: 131 - 178 publication: Current Developments in Mathematics, 2001 publication_identifier: isbn: - '9781571461018' publication_status: published publisher: International Press publist_id: '4588' status: public title: The ground state of the Bose gas type: book_chapter user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 year: '2002' ... --- _id: '1737' abstract: - lang: eng text: A new solvent-free composite polymer electrolyte consisting of high-molecular mass polyethylene oxide (PEO) filled with titanium oxide and containing LiI and I2 was developed. The introduction of the inorganic filler (TiO2 Degussa P25) into the polymer matrix produces dramatic morphological changes to the host polymer structure. Upon addition of the inorganic oxide, the surface roughness increases, with respect to the original polymer and in parallel, the fractal dimension decreases. Both the thermograms and the atomic force microscope (AFM) pictures confirm the amorphicity of the composite electrolyte. The polymer sub-units are held together in a parallel orientation, forming straight long chains of about 500 nm in width, along which TiO2 spherical particles of about 20-25 nm in diameter are distributed. The polymer chains separated by the titania particles are arranged in a three-dimensional, mechanically stable network, that creates free space and voids into which the iodide/triodide anions can easily migrate. All solid-state dye-sensitized solar cells fabricated using this composite electrolyte present high efficiencies (typical maximum incident photon to current efficiency (IPCE) as high as 40% at 520 nm and overall conversion efficiency (η) of 0.96% (Voc = 0.67 V, Jsc = 2.050 mA/cm2, FF = 39%) under direct solar irradiation. Further improvement of the photovoltaic performance is expected by optimization of the electrolyte parameters and of the cell assembly. acknowledgement: Financial support from NCSR “Demokritos” (Dimoerevna 598 project), Empeirikeion Foundation and General Secretariat for Research and Technology of Greece (EPET II, Greece–France and Greece–Czech Republic bilateral collaboration projects) is also greatly acknowledged. G. Katsaros thanks the Greek State Scholarships Foundation (IKY) for fellowship allowance article_processing_charge: No author: - first_name: Georgios full_name: Katsaros, Georgios id: 38DB5788-F248-11E8-B48F-1D18A9856A87 last_name: Katsaros - first_name: Thomas full_name: Stergiopoulos, Thomas last_name: Stergiopoulos - first_name: Iannis full_name: Arabatzis, Iannis last_name: Arabatzis - first_name: Kyriaki full_name: Papadokostaki, Kyriaki last_name: Papadokostaki - first_name: Polycarpos full_name: Falaras, Polycarpos last_name: Falaras citation: ama: 'Katsaros G, Stergiopoulos T, Arabatzis I, Papadokostaki K, Falaras P. A solvent-free composite polymer/inorganic oxide electrolyte for high efficiency solid-state dye-sensitized solar cells. Journal of Photochemistry and Photobiology A: Chemistry. 2002;149(1-3):191-198. doi:10.1016/S1010-6030(02)00027-8' apa: 'Katsaros, G., Stergiopoulos, T., Arabatzis, I., Papadokostaki, K., & Falaras, P. (2002). A solvent-free composite polymer/inorganic oxide electrolyte for high efficiency solid-state dye-sensitized solar cells. Journal of Photochemistry and Photobiology A: Chemistry. Elsevier. https://doi.org/10.1016/S1010-6030(02)00027-8' chicago: 'Katsaros, Georgios, Thomas Stergiopoulos, Iannis Arabatzis, Kyriaki Papadokostaki, and Polycarpos Falaras. “A Solvent-Free Composite Polymer/Inorganic Oxide Electrolyte for High Efficiency Solid-State Dye-Sensitized Solar Cells.” Journal of Photochemistry and Photobiology A: Chemistry. Elsevier, 2002. https://doi.org/10.1016/S1010-6030(02)00027-8.' ieee: 'G. Katsaros, T. Stergiopoulos, I. Arabatzis, K. Papadokostaki, and P. Falaras, “A solvent-free composite polymer/inorganic oxide electrolyte for high efficiency solid-state dye-sensitized solar cells,” Journal of Photochemistry and Photobiology A: Chemistry, vol. 149, no. 1–3. Elsevier, pp. 191–198, 2002.' ista: 'Katsaros G, Stergiopoulos T, Arabatzis I, Papadokostaki K, Falaras P. 2002. A solvent-free composite polymer/inorganic oxide electrolyte for high efficiency solid-state dye-sensitized solar cells. Journal of Photochemistry and Photobiology A: Chemistry. 149(1–3), 191–198.' mla: 'Katsaros, Georgios, et al. “A Solvent-Free Composite Polymer/Inorganic Oxide Electrolyte for High Efficiency Solid-State Dye-Sensitized Solar Cells.” Journal of Photochemistry and Photobiology A: Chemistry, vol. 149, no. 1–3, Elsevier, 2002, pp. 191–98, doi:10.1016/S1010-6030(02)00027-8.' short: 'G. Katsaros, T. Stergiopoulos, I. Arabatzis, K. Papadokostaki, P. Falaras, Journal of Photochemistry and Photobiology A: Chemistry 149 (2002) 191–198.' date_created: 2018-12-11T11:53:44Z date_published: 2002-06-28T00:00:00Z date_updated: 2023-07-26T08:56:55Z day: '28' doi: 10.1016/S1010-6030(02)00027-8 extern: '1' intvolume: ' 149' issue: 1-3 language: - iso: eng month: '06' oa_version: None page: 191 - 198 publication: 'Journal of Photochemistry and Photobiology A: Chemistry' publication_identifier: issn: - 1010-6030 publication_status: published publisher: Elsevier publist_id: '5387' status: public title: A solvent-free composite polymer/inorganic oxide electrolyte for high efficiency solid-state dye-sensitized solar cells type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 149 year: '2002' ... --- _id: '2350' abstract: - lang: eng text: Using the Pauli-Fierz model of non-relativistic quantum electrodynamics, we calculate the binding energy of an electron in the field of a nucleus of charge Z and in presence of the quantized radiation field. We consider the case of small coupling constant α, but fixed Zα and ultraviolet cut-off Λ. We prove that after renormalizing the mass the binding energy has, to leading order in α, a finite limit as Λ goes to infinity; i.e., the cut-off can be removed. The expression for the ground state energy shift thus obtained agrees with Bethe's formula for small values of Zα, but shows a different behavior for bigger values. acknowledgement: "We are grateful to Elliott Lieb for helpful discussions. C.H. was supported by a Marie Curie Fellowship of the European Community programme “Improving Human Research Potential and the Socioeconomic Knowledge Base” under contract number HPMFCT-2000-00660 and by the Deutsche Forschungsgemeinschaft, and acknowledges kind hospitality at Princeton University, where part of this work was done. R.S. was supported by the Austrian Science Fund in the form of an Erwin Schrödinger Fellowship.\r\n" article_processing_charge: No article_type: original author: - first_name: Christian full_name: Hainzl, Christian last_name: Hainzl - first_name: Robert full_name: Seiringer, Robert id: 4AFD0470-F248-11E8-B48F-1D18A9856A87 last_name: Seiringer orcid: 0000-0002-6781-0521 citation: ama: Hainzl C, Seiringer R. Mass renormalization and energy level shift in non-relativistic QED. Advances in Theoretical and Mathematical Physics. 2002;6(5):847-871. doi:10.4310/ATMP.2002.v6.n5.a3 apa: Hainzl, C., & Seiringer, R. (2002). Mass renormalization and energy level shift in non-relativistic QED. Advances in Theoretical and Mathematical Physics. International Press. https://doi.org/10.4310/ATMP.2002.v6.n5.a3 chicago: Hainzl, Christian, and Robert Seiringer. “Mass Renormalization and Energy Level Shift in Non-Relativistic QED.” Advances in Theoretical and Mathematical Physics. International Press, 2002. https://doi.org/10.4310/ATMP.2002.v6.n5.a3. ieee: C. Hainzl and R. Seiringer, “Mass renormalization and energy level shift in non-relativistic QED,” Advances in Theoretical and Mathematical Physics, vol. 6, no. 5. International Press, pp. 847–871, 2002. ista: Hainzl C, Seiringer R. 2002. Mass renormalization and energy level shift in non-relativistic QED. Advances in Theoretical and Mathematical Physics. 6(5), 847–871. mla: Hainzl, Christian, and Robert Seiringer. “Mass Renormalization and Energy Level Shift in Non-Relativistic QED.” Advances in Theoretical and Mathematical Physics, vol. 6, no. 5, International Press, 2002, pp. 847–71, doi:10.4310/ATMP.2002.v6.n5.a3. short: C. Hainzl, R. Seiringer, Advances in Theoretical and Mathematical Physics 6 (2002) 847–871. date_created: 2018-12-11T11:57:09Z date_published: 2002-09-01T00:00:00Z date_updated: 2023-07-26T08:29:28Z day: '01' doi: 10.4310/ATMP.2002.v6.n5.a3 extern: '1' external_id: arxiv: - math-ph/0205044v3 intvolume: ' 6' issue: '5' language: - iso: eng main_file_link: - open_access: '1' url: http://arxiv.org/abs/math-ph/0205044 month: '09' oa: 1 oa_version: Published Version page: 847 - 871 publication: Advances in Theoretical and Mathematical Physics publication_identifier: issn: - 1095-0761 publication_status: published publisher: International Press publist_id: '4574' quality_controlled: '1' scopus_import: '1' status: public title: Mass renormalization and energy level shift in non-relativistic QED type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 6 year: '2002' ... --- _id: '885' abstract: - lang: eng text: We study fitness landscape in the space of protein sequences by relating sets of human pathogenic missense mutations in 32 proteins to amino acid substitutions that occurred in the course of evolution of these proteins. On average, ≈10% of deviations of a nonhuman protein from its human ortholog are compensated pathogenic deviations (CPDs), i.e., are caused by an amino acid substitution that, at this site, would be pathogenic to humans. Normal functioning of a CPD-containing protein must be caused by other, compensatory deviations of the nonhuman species from humans. Together, a CPD and the corresponding compensatory deviation form a Dobzhansky-Muller incompatibility that can be visualized as the corner on a fitness ridge. Thus, proteins evolve along fitness ridges which contain only ≈10 steps between sucessive corners. The fraction of CPDs among all deviations of a protein from its human ortholog does not increase with the evolutionary distance between the proteins, indicating that subtitutions that carry evolving proteins around these corners occur in rapid succession, driven by positive selection. Data on fitness of interspecies hybrids suggest that the compensatory change that makes a CPD fit usually occurs within the same protein. Data on protein structures and on cooccurrence of amino acids at different sites of multiple orthologous proteins often make it possible to provisionally identify the substitution that compensates a partiCUlar CPD. article_processing_charge: No article_type: original author: - first_name: Alexey full_name: Kondrashov, Alexey last_name: Kondrashov - first_name: Shamil full_name: Sunyaev, Shamil last_name: Sunyaev - first_name: Fyodor full_name: Kondrashov, Fyodor id: 44FDEF62-F248-11E8-B48F-1D18A9856A87 last_name: Kondrashov orcid: 0000-0001-8243-4694 citation: ama: Kondrashov A, Sunyaev S, Kondrashov F. Dobzhansky-Muller incompatibilities in protein evolution. PNAS. 2002;99(23):14878-14883. doi:10.1073/pnas.232565499 apa: Kondrashov, A., Sunyaev, S., & Kondrashov, F. (2002). Dobzhansky-Muller incompatibilities in protein evolution. PNAS. National Academy of Sciences. https://doi.org/10.1073/pnas.232565499 chicago: Kondrashov, Alexey, Shamil Sunyaev, and Fyodor Kondrashov. “Dobzhansky-Muller Incompatibilities in Protein Evolution.” PNAS. National Academy of Sciences, 2002. https://doi.org/10.1073/pnas.232565499. ieee: A. Kondrashov, S. Sunyaev, and F. Kondrashov, “Dobzhansky-Muller incompatibilities in protein evolution,” PNAS, vol. 99, no. 23. National Academy of Sciences, pp. 14878–14883, 2002. ista: Kondrashov A, Sunyaev S, Kondrashov F. 2002. Dobzhansky-Muller incompatibilities in protein evolution. PNAS. 99(23), 14878–14883. mla: Kondrashov, Alexey, et al. “Dobzhansky-Muller Incompatibilities in Protein Evolution.” PNAS, vol. 99, no. 23, National Academy of Sciences, 2002, pp. 14878–83, doi:10.1073/pnas.232565499. short: A. Kondrashov, S. Sunyaev, F. Kondrashov, PNAS 99 (2002) 14878–14883. date_created: 2018-12-11T11:49:01Z date_published: 2002-11-12T00:00:00Z date_updated: 2023-07-26T09:48:37Z day: '12' doi: 10.1073/pnas.232565499 extern: '1' external_id: pmid: - '12403824' intvolume: ' 99' issue: '23' language: - iso: eng main_file_link: - open_access: '1' url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC137512/ month: '11' oa: 1 oa_version: Published Version page: 14878 - 14883 pmid: 1 publication: PNAS publication_identifier: issn: - 0027-8424 publication_status: published publisher: National Academy of Sciences publist_id: '6763' quality_controlled: '1' scopus_import: '1' status: public title: Dobzhansky-Muller incompatibilities in protein evolution type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 99 year: '2002' ...