[{"publication_status":"published","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa_version":"None","_id":"11764","article_processing_charge":"No","date_updated":"2024-11-06T08:21:48Z","page":"314-332","doi":"10.1016/s0196-6774(03)00054-3","language":[{"iso":"eng"}],"author":[{"first_name":"Ashish","full_name":"Goel, Ashish","last_name":"Goel"},{"id":"540c9bbd-f2de-11ec-812d-d04a5be85630","first_name":"Monika H","full_name":"Henzinger, Monika H","last_name":"Henzinger","orcid":"0000-0002-5008-6530"},{"first_name":"Serge","full_name":"Plotkin, Serge","last_name":"Plotkin"},{"last_name":"Tardos","full_name":"Tardos, Eva","first_name":"Eva"}],"month":"09","title":"Scheduling data transfers in a network and the set scheduling problem","publication_identifier":{"issn":["0196-6774"]},"date_created":"2022-08-08T12:09:32Z","publication":"Journal of Algorithms","type":"journal_article","status":"public","citation":{"apa":"Goel, A., Henzinger, M., Plotkin, S., &#38; Tardos, E. (2003). Scheduling data transfers in a network and the set scheduling problem. <i>Journal of Algorithms</i>. Elsevier. <a href=\"https://doi.org/10.1016/s0196-6774(03)00054-3\">https://doi.org/10.1016/s0196-6774(03)00054-3</a>","mla":"Goel, Ashish, et al. “Scheduling Data Transfers in a Network and the Set Scheduling Problem.” <i>Journal of Algorithms</i>, vol. 48, no. 2, Elsevier, 2003, pp. 314–32, doi:<a href=\"https://doi.org/10.1016/s0196-6774(03)00054-3\">10.1016/s0196-6774(03)00054-3</a>.","ista":"Goel A, Henzinger M, Plotkin S, Tardos E. 2003. Scheduling data transfers in a network and the set scheduling problem. Journal of Algorithms. 48(2), 314–332.","ieee":"A. Goel, M. Henzinger, S. Plotkin, and E. Tardos, “Scheduling data transfers in a network and the set scheduling problem,” <i>Journal of Algorithms</i>, vol. 48, no. 2. Elsevier, pp. 314–332, 2003.","chicago":"Goel, Ashish, Monika Henzinger, Serge Plotkin, and Eva Tardos. “Scheduling Data Transfers in a Network and the Set Scheduling Problem.” <i>Journal of Algorithms</i>. Elsevier, 2003. <a href=\"https://doi.org/10.1016/s0196-6774(03)00054-3\">https://doi.org/10.1016/s0196-6774(03)00054-3</a>.","short":"A. Goel, M. Henzinger, S. Plotkin, E. Tardos, Journal of Algorithms 48 (2003) 314–332.","ama":"Goel A, Henzinger M, Plotkin S, Tardos E. Scheduling data transfers in a network and the set scheduling problem. <i>Journal of Algorithms</i>. 2003;48(2):314-332. doi:<a href=\"https://doi.org/10.1016/s0196-6774(03)00054-3\">10.1016/s0196-6774(03)00054-3</a>"},"publisher":"Elsevier","issue":"2","quality_controlled":"1","scopus_import":"1","year":"2003","volume":48,"date_published":"2003-09-01T00:00:00Z","intvolume":"        48","article_type":"original","extern":"1","day":"01","abstract":[{"text":"In this paper we consider the online ftp problem. The goal is to service a sequence of file transfer requests given bandwidth constraints of the underlying communication network. The main result of the paper is a technique that leads to algorithms that optimize several natural metrics, such as max-stretch, total flow time, max flow time, and total completion time. In particular, we show how to achieve optimum total flow time and optimum max-stretch if we increase the capacity of the underlying network by a logarithmic factor. We show that the resource augmentation is necessary by proving polynomial lower bounds on the max-stretch and total flow time for the case where online and offline algorithms are using same-capacity edges. Moreover, we also give polylogarithmic lower bounds on the resource augmentation factor necessary in order to keep the total flow time and max-stretch within a constant factor of optimum.","lang":"eng"}]},{"volume":66,"publisher":"Elsevier","citation":{"mla":"Henzinger, Monika, and Stefano Leonardi. “Scheduling Multicasts on Unit-Capacity Trees and Meshes.” <i>Journal of Computer and System Sciences</i>, vol. 66, no. 3, Elsevier, 2003, pp. 567–611, doi:<a href=\"https://doi.org/10.1016/s0022-0000(03)00043-6\">10.1016/s0022-0000(03)00043-6</a>.","apa":"Henzinger, M., &#38; Leonardi, S. (2003). Scheduling multicasts on unit-capacity trees and meshes. <i>Journal of Computer and System Sciences</i>. Elsevier. <a href=\"https://doi.org/10.1016/s0022-0000(03)00043-6\">https://doi.org/10.1016/s0022-0000(03)00043-6</a>","ista":"Henzinger M, Leonardi S. 2003. Scheduling multicasts on unit-capacity trees and meshes. Journal of Computer and System Sciences. 66(3), 567–611.","chicago":"Henzinger, Monika, and Stefano Leonardi. “Scheduling Multicasts on Unit-Capacity Trees and Meshes.” <i>Journal of Computer and System Sciences</i>. Elsevier, 2003. <a href=\"https://doi.org/10.1016/s0022-0000(03)00043-6\">https://doi.org/10.1016/s0022-0000(03)00043-6</a>.","ieee":"M. Henzinger and S. Leonardi, “Scheduling multicasts on unit-capacity trees and meshes,” <i>Journal of Computer and System Sciences</i>, vol. 66, no. 3. Elsevier, pp. 567–611, 2003.","ama":"Henzinger M, Leonardi S. Scheduling multicasts on unit-capacity trees and meshes. <i>Journal of Computer and System Sciences</i>. 2003;66(3):567-611. doi:<a href=\"https://doi.org/10.1016/s0022-0000(03)00043-6\">10.1016/s0022-0000(03)00043-6</a>","short":"M. Henzinger, S. Leonardi, Journal of Computer and System Sciences 66 (2003) 567–611."},"quality_controlled":"1","article_type":"original","intvolume":"        66","oa_version":"Published Version","publication_status":"published","page":"567-611","_id":"11766","article_processing_charge":"No","language":[{"iso":"eng"}],"author":[{"id":"540c9bbd-f2de-11ec-812d-d04a5be85630","first_name":"Monika H","full_name":"Henzinger, Monika H","last_name":"Henzinger","orcid":"0000-0002-5008-6530"},{"first_name":"Stefano","full_name":"Leonardi, Stefano","last_name":"Leonardi"}],"year":"2003","oa":1,"issue":"3","type":"journal_article","status":"public","scopus_import":"1","extern":"1","day":"01","abstract":[{"text":"This paper studies the multicast routing and admission control problem on unit-capacity tree and mesh topologies in the throughput model. The problem is a generalization of the edge-disjoint paths problem and is NP-hard both on trees and meshes. We study both the offline and the online version of the problem: In the offline setting, we give the first constant-factor approximation algorithm for trees, and an -factor approximation algorithm for meshes. In the online setting, we give the first polylogarithmic competitive online algorithm for tree and mesh topologies. No polylogarithmic-competitive algorithm is possible on general network topologies (Lower bounds for on-line graph problems with application to on-line circuits and optical routing, in: Proceedings of the 28th ACM Symposium on Theory of Computing, 1996, pp. 531–540) and there exists a polylogarithmic lower bound on the competitive ratio of any online algorithm on tree topologies (Making commitments in the face of uncertainity: how to pick a winner almost every time, in: Proceedings of the 28th Annual ACM Symposium on Theory of Computing, 1996, pp. 519–530). We prove the same lower bound for meshes.","lang":"eng"}],"main_file_link":[{"url":"https://doi.org/10.1016/S0022-0000(03)00043-6","open_access":"1"}],"date_published":"2003-05-01T00:00:00Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"issn":["0022-0000"]},"month":"05","title":"Scheduling multicasts on unit-capacity trees and meshes","publication":"Journal of Computer and System Sciences","date_created":"2022-08-08T12:24:35Z","date_updated":"2024-11-06T08:21:23Z","doi":"10.1016/s0022-0000(03)00043-6"},{"oa_version":"None","conference":{"location":"Budapest, Hungary","end_date":"2003-05-24","name":"WWW: International Conference on World Wide Web","start_date":"2003-05-20"},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_status":"published","publication":"Proceedings of the 12th international conference on World Wide Web","date_created":"2022-08-16T08:55:05Z","publication_identifier":{"isbn":["978-158113680-7"]},"month":"05","related_material":{"record":[{"id":"11904","status":"public","relation":"later_version"}]},"title":"Query-free news search","author":[{"orcid":"0000-0002-5008-6530","last_name":"Henzinger","full_name":"Henzinger, Monika H","first_name":"Monika H","id":"540c9bbd-f2de-11ec-812d-d04a5be85630"},{"last_name":"Chang","full_name":"Chang, Bay-Wei","first_name":"Bay-Wei"},{"first_name":"Brian","full_name":"Milch, Brian","last_name":"Milch"},{"full_name":"Brin, Sergey","last_name":"Brin","first_name":"Sergey"}],"language":[{"iso":"eng"}],"doi":"10.1145/775152.775154","date_updated":"2024-11-06T12:24:35Z","article_processing_charge":"No","_id":"11860","year":"2003","article_number":"1-10","quality_controlled":"1","scopus_import":"1","publisher":"Association for Computing Machinery","citation":{"apa":"Henzinger, M., Chang, B.-W., Milch, B., &#38; Brin, S. (2003). Query-free news search. In <i>Proceedings of the 12th international conference on World Wide Web</i>. Budapest, Hungary: Association for Computing Machinery. <a href=\"https://doi.org/10.1145/775152.775154\">https://doi.org/10.1145/775152.775154</a>","mla":"Henzinger, Monika, et al. “Query-Free News Search.” <i>Proceedings of the 12th International Conference on World Wide Web</i>, 1–10, Association for Computing Machinery, 2003, doi:<a href=\"https://doi.org/10.1145/775152.775154\">10.1145/775152.775154</a>.","ieee":"M. Henzinger, B.-W. Chang, B. Milch, and S. Brin, “Query-free news search,” in <i>Proceedings of the 12th international conference on World Wide Web</i>, Budapest, Hungary, 2003.","chicago":"Henzinger, Monika, Bay-Wei Chang, Brian Milch, and Sergey Brin. “Query-Free News Search.” In <i>Proceedings of the 12th International Conference on World Wide Web</i>. Association for Computing Machinery, 2003. <a href=\"https://doi.org/10.1145/775152.775154\">https://doi.org/10.1145/775152.775154</a>.","ista":"Henzinger M, Chang B-W, Milch B, Brin S. 2003. Query-free news search. Proceedings of the 12th international conference on World Wide Web. WWW: International Conference on World Wide Web, 1–10.","short":"M. Henzinger, B.-W. Chang, B. Milch, S. Brin, in:, Proceedings of the 12th International Conference on World Wide Web, Association for Computing Machinery, 2003.","ama":"Henzinger M, Chang B-W, Milch B, Brin S. Query-free news search. In: <i>Proceedings of the 12th International Conference on World Wide Web</i>. Association for Computing Machinery; 2003. doi:<a href=\"https://doi.org/10.1145/775152.775154\">10.1145/775152.775154</a>"},"type":"conference","status":"public","abstract":[{"lang":"eng","text":"Many daily activities present information in the form of a stream of text, and often people can benefit from additional information on the topic discussed. TV broadcast news can be treated as one such stream of text; in this paper we discuss finding news articles on the web that are relevant to news currently being broadcast.We evaluated a variety of algorithms for this problem, looking at the impact of inverse document frequency, stemming, compounds, history, and query length on the relevance and coverage of news articles returned in real time during a broadcast. We also evaluated several postprocessing techniques for improving the precision, including reranking using additional terms, reranking by document similarity, and filtering on document similarity. For the best algorithm, 84%-91% of the articles found were relevant, with at least 64% of the articles being on the exact topic of the broadcast. In addition, a relevant article was found for at least 70% of the topics."}],"extern":"1","day":"01","date_published":"2003-05-01T00:00:00Z"},{"doi":"10.1145/290941.290972","author":[{"full_name":"Bharat, Krishna","last_name":"Bharat","first_name":"Krishna"},{"full_name":"Henzinger, Monika H","orcid":"0000-0002-5008-6530","last_name":"Henzinger","id":"540c9bbd-f2de-11ec-812d-d04a5be85630","first_name":"Monika H"}],"language":[{"iso":"eng"}],"_id":"11897","article_processing_charge":"No","date_updated":"2024-11-06T12:23:38Z","page":"104–111","date_created":"2022-08-17T08:56:18Z","publication":"21st annual international ACM SIGIR conference on Research and development in information retrieval","publication_identifier":{"issn":["01635840"],"isbn":["978-1-58113-015-7"]},"month":"08","title":"Improved algorithms for topic distillation in a hyperlinked environment","publication_status":"published","oa_version":"None","conference":{"name":"SIGIR: International Conference on Research and Development in Information Retrieval","start_date":"1998-08-24","location":"Melbourne, Australia","end_date":"1998-08-28"},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_published":"2003-08-01T00:00:00Z","abstract":[{"lang":"eng","text":"This paper addresses the problem of topic distillation on the World Wide Web, namely, given a typical user query to find quality documents related to the query topic. Connectivity analysis has been shown to be useful in identifying high quality pages within a topic specific graph of hyperlinked documents. The essence of our approach is to augment a previous connectivity analysis based algorithm with content analysis. We identify three problems with the existing approach and devise algorithms to tackle them. The results of a user evaluation are reported that show an improvement of precision at 10\r\ndocuments by at least 45% over pure connectivity analysis. "}],"day":"01","extern":"1","scopus_import":"1","quality_controlled":"1","citation":{"apa":"Bharat, K., &#38; Henzinger, M. (2003). Improved algorithms for topic distillation in a hyperlinked environment. In <i>21st annual international ACM SIGIR conference on Research and development in information retrieval</i> (pp. 104–111). Melbourne, Australia: Association for Computing Machinery. <a href=\"https://doi.org/10.1145/290941.290972\">https://doi.org/10.1145/290941.290972</a>","mla":"Bharat, Krishna, and Monika Henzinger. “Improved Algorithms for Topic Distillation in a Hyperlinked Environment.” <i>21st Annual International ACM SIGIR Conference on Research and Development in Information Retrieval</i>, Association for Computing Machinery, 2003, pp. 104–111, doi:<a href=\"https://doi.org/10.1145/290941.290972\">10.1145/290941.290972</a>.","ama":"Bharat K, Henzinger M. Improved algorithms for topic distillation in a hyperlinked environment. In: <i>21st Annual International ACM SIGIR Conference on Research and Development in Information Retrieval</i>. Association for Computing Machinery; 2003:104–111. doi:<a href=\"https://doi.org/10.1145/290941.290972\">10.1145/290941.290972</a>","short":"K. Bharat, M. Henzinger, in:, 21st Annual International ACM SIGIR Conference on Research and Development in Information Retrieval, Association for Computing Machinery, 2003, pp. 104–111.","ista":"Bharat K, Henzinger M. 2003. Improved algorithms for topic distillation in a hyperlinked environment. 21st annual international ACM SIGIR conference on Research and development in information retrieval. SIGIR: International Conference on Research and Development in Information Retrieval, 104–111.","ieee":"K. Bharat and M. Henzinger, “Improved algorithms for topic distillation in a hyperlinked environment,” in <i>21st annual international ACM SIGIR conference on Research and development in information retrieval</i>, Melbourne, Australia, 2003, pp. 104–111.","chicago":"Bharat, Krishna, and Monika Henzinger. “Improved Algorithms for Topic Distillation in a Hyperlinked Environment.” In <i>21st Annual International ACM SIGIR Conference on Research and Development in Information Retrieval</i>, 104–111. Association for Computing Machinery, 2003. <a href=\"https://doi.org/10.1145/290941.290972\">https://doi.org/10.1145/290941.290972</a>."},"status":"public","type":"conference","publisher":"Association for Computing Machinery","year":"2003"},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa_version":"Published Version","conference":{"start_date":"2003-08-09","name":"IJCAI: International Joint Conference on Artificial Intelligence","end_date":"2003-08-15","location":"Acapulco, Mexico"},"publication_status":"published","title":"Challenges in web search engines","publication_identifier":{"issn":["1045-0823"]},"month":"08","date_created":"2022-08-18T06:40:02Z","publication":"18th International Joint Conference on Artificial Intelligence","_id":"11909","article_processing_charge":"No","date_updated":"2024-11-06T08:13:06Z","page":"1573-1579","language":[{"iso":"eng"}],"author":[{"full_name":"Henzinger, Monika H","orcid":"0000-0002-5008-6530","last_name":"Henzinger","first_name":"Monika H","id":"540c9bbd-f2de-11ec-812d-d04a5be85630"},{"full_name":"Motwani, Rajeev","last_name":"Motwani","first_name":"Rajeev"},{"first_name":"Craig","last_name":"Silverstein","full_name":"Silverstein, Craig"}],"year":"2003","oa":1,"type":"conference","citation":{"ama":"Henzinger M, Motwani R, Silverstein C. Challenges in web search engines. In: <i>18th International Joint Conference on Artificial Intelligence</i>. Association for Computing Machinery; 2003:1573-1579.","short":"M. Henzinger, R. Motwani, C. Silverstein, in:, 18th International Joint Conference on Artificial Intelligence, Association for Computing Machinery, 2003, pp. 1573–1579.","ista":"Henzinger M, Motwani R, Silverstein C. 2003. Challenges in web search engines. 18th International Joint Conference on Artificial Intelligence. IJCAI: International Joint Conference on Artificial Intelligence, 1573–1579.","ieee":"M. Henzinger, R. Motwani, and C. Silverstein, “Challenges in web search engines,” in <i>18th International Joint Conference on Artificial Intelligence</i>, Acapulco, Mexico, 2003, pp. 1573–1579.","chicago":"Henzinger, Monika, Rajeev Motwani, and Craig Silverstein. “Challenges in Web Search Engines.” In <i>18th International Joint Conference on Artificial Intelligence</i>, 1573–79. Association for Computing Machinery, 2003.","mla":"Henzinger, Monika, et al. “Challenges in Web Search Engines.” <i>18th International Joint Conference on Artificial Intelligence</i>, Association for Computing Machinery, 2003, pp. 1573–79.","apa":"Henzinger, M., Motwani, R., &#38; Silverstein, C. (2003). Challenges in web search engines. In <i>18th International Joint Conference on Artificial Intelligence</i> (pp. 1573–1579). Acapulco, Mexico: Association for Computing Machinery."},"status":"public","publisher":"Association for Computing Machinery","scopus_import":"1","quality_controlled":"1","extern":"1","day":"01","abstract":[{"lang":"eng","text":"This article presents a high-level discussion of some problems that are unique to web search engines. The goal is to raise awareness and stimulate research in these areas."}],"date_published":"2003-08-01T00:00:00Z","main_file_link":[{"url":"https://www.ijcai.org/Proceedings/03/Papers/278.pdf","open_access":"1"}]},{"date_published":"2003-03-01T00:00:00Z","intvolume":"        53","abstract":[{"text":"Patients with Hodgkin's disease can develop paraneoplastic cerebellar ataxia because of the generation of autoantibodies against mGluR1 (mGluR1-Abs). Yet, the pathophysiological mechanisms underlying their motor coordination deficits remain to be elucidated. Here, we show that application of IgG purified from the patients' serum to cerebellar slices of mice acutely reduces the basal activity of Purkinje cells, whereas application to the flocculus of mice in vivo evokes acute disturbances in the performance of their compensatory eye movements. In addition, the mGluR1-Abs block induction of long-term depression in cultured mouse Purkinje cells, whereas the cerebellar motor learning behavior of the patients is affected in that they show impaired adaptation of their saccadic eye movements. Finally, postmortem analysis of the cerebellum of a paraneoplastic cerebellar ataxia patient showed that the number of Purkinje cells was significantly reduced by approximately two thirds compared with three controls. We conclude that autoantibodies against mGluR1 can cause cerebellar motor coordination deficits caused by a combination of rapid effects on both acute and plastic responses of Purkinje cells and chronic degenerative effects.","lang":"eng"}],"day":"01","extern":1,"quality_controlled":0,"citation":{"apa":"Coesmans, M., Sillevis Smitt, P., Linden, D., Shigemoto, R., Hirano, T., Yamakawa, Y., … De Zeeuw, C. (2003). Mechanisms underlying cerebellar motor deficits due to mGluR1-autoantibodies. <i>Annals of Neurology</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1002/ana.10451\">https://doi.org/10.1002/ana.10451</a>","mla":"Coesmans, Michiel, et al. “Mechanisms Underlying Cerebellar Motor Deficits Due to MGluR1-Autoantibodies.” <i>Annals of Neurology</i>, vol. 53, no. 3, Wiley-Blackwell, 2003, pp. 325–36, doi:<a href=\"https://doi.org/10.1002/ana.10451\">10.1002/ana.10451</a>.","ieee":"M. Coesmans <i>et al.</i>, “Mechanisms underlying cerebellar motor deficits due to mGluR1-autoantibodies,” <i>Annals of Neurology</i>, vol. 53, no. 3. Wiley-Blackwell, pp. 325–336, 2003.","chicago":"Coesmans, Michiel, Peter Sillevis Smitt, David Linden, Ryuichi Shigemoto, Tomoo Hirano, Yoshinori Yamakawa, Adriaan Van Alphen, et al. “Mechanisms Underlying Cerebellar Motor Deficits Due to MGluR1-Autoantibodies.” <i>Annals of Neurology</i>. Wiley-Blackwell, 2003. <a href=\"https://doi.org/10.1002/ana.10451\">https://doi.org/10.1002/ana.10451</a>.","ista":"Coesmans M, Sillevis Smitt P, Linden D, Shigemoto R, Hirano T, Yamakawa Y, Van Alphen A, Luo C, Van Der Geest J, Kros J, Gaillard C, Frens M, De Zeeuw C. 2003. Mechanisms underlying cerebellar motor deficits due to mGluR1-autoantibodies. Annals of Neurology. 53(3), 325–336.","ama":"Coesmans M, Sillevis Smitt P, Linden D, et al. Mechanisms underlying cerebellar motor deficits due to mGluR1-autoantibodies. <i>Annals of Neurology</i>. 2003;53(3):325-336. doi:<a href=\"https://doi.org/10.1002/ana.10451\">10.1002/ana.10451</a>","short":"M. Coesmans, P. Sillevis Smitt, D. Linden, R. Shigemoto, T. Hirano, Y. Yamakawa, A. Van Alphen, C. Luo, J. Van Der Geest, J. Kros, C. Gaillard, M. Frens, C. De Zeeuw, Annals of Neurology 53 (2003) 325–336."},"type":"journal_article","status":"public","publisher":"Wiley-Blackwell","issue":"3","volume":53,"year":"2003","doi":"10.1002/ana.10451","author":[{"first_name":"Michiel","last_name":"Coesmans","full_name":"Coesmans, Michiel P"},{"last_name":"Sillevis Smitt","full_name":"Sillevis-Smitt, Peter A","first_name":"Peter"},{"first_name":"David","full_name":"Linden, David J","last_name":"Linden"},{"full_name":"Ryuichi Shigemoto","orcid":"0000-0001-8761-9444","last_name":"Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi"},{"first_name":"Tomoo","last_name":"Hirano","full_name":"Hirano, Tomoo"},{"first_name":"Yoshinori","full_name":"Yamakawa, Yoshinori","last_name":"Yamakawa"},{"first_name":"Adriaan","last_name":"Van Alphen","full_name":"Van Alphen, Adriaan M"},{"first_name":"Chongde","last_name":"Luo","full_name":"Luo, Chongde"},{"first_name":"Jos","last_name":"Van Der Geest","full_name":"Van Der Geest, Jos N"},{"first_name":"Johan","last_name":"Kros","full_name":"Kros, Johan M"},{"full_name":"Gaillard, Carlo A","last_name":"Gaillard","first_name":"Carlo"},{"full_name":"Frens, Maarten A","last_name":"Frens","first_name":"Maarten"},{"full_name":"De Zeeuw, Chris I","last_name":"De Zeeuw","first_name":"Chris"}],"_id":"2623","date_updated":"2021-01-12T06:58:39Z","page":"325 - 336","date_created":"2018-12-11T11:58:44Z","publication":"Annals of Neurology","title":"Mechanisms underlying cerebellar motor deficits due to mGluR1-autoantibodies","month":"03","publication_status":"published","publist_id":"4274"},{"abstract":[{"lang":"eng","text":"Metabotropic glutamate receptor 1 (mGluR1) plays a crucial role in synaptic plasticity and motor learning in the cerebellum. We have studied activity-dependent changes in mGluR1 function in mouse cultured Purkinje neurons. Depolarizing stimulation potentiated Ca2+ and current responses to an mGluR1 agonist for several hours in the cultured Purkinje neurons. It also blocked internalization of mGluR1 and increased the number of mGluR1s on the cell membrane. We found that depolarization simultaneously increased transcription of Homer1a in Purkinje neurons. Homer1a inhibited internalization and increased cell-surface expression of mGluR1 when coexpressed in human embryonic kidney (HEK)-293 cells. Depolarization-induced Homer1a expression in Purkinje neurons was blocked by a mitogen-activated protein kinase (MAPK) inhibitor. Changes in internalization and mGluR1-mediated Ca2+ response were also blocked by inhibition of MAPK activity, suggesting that localization and activity of mGluR1 were regulated in the same signalling pathway as Homer1a expression. It is thus suggested that depolarization of the Purkinje neuron leads to the increment in mGluR1 responsiveness through MAPK activity and induction of Homer1a expression, which increases active mGluR1 on the cell surface by blocking internalization of mGluR1."}],"day":"01","extern":1,"date_published":"2003-03-01T00:00:00Z","intvolume":"        17","volume":17,"year":"2003","quality_controlled":0,"status":"public","citation":{"ista":"Minami I, Kengaku M, Smitt S, Shigemoto R, Hirano T. 2003. Long-term potentiation of mGluR1 activity by depolarization-induced Homer1a in mouse cerebellar Purkinje neurons. European Journal of Neuroscience. 17(5), 1023–1032.","chicago":"Minami, Itsunari, Mineko Kengaku, Sillevis Smitt, Ryuichi Shigemoto, and Tomoo Hirano. “Long-Term Potentiation of MGluR1 Activity by Depolarization-Induced Homer1a in Mouse Cerebellar Purkinje Neurons.” <i>European Journal of Neuroscience</i>. Wiley-Blackwell, 2003. <a href=\"https://doi.org/10.1046/j.1460-9568.2003.02499.x\">https://doi.org/10.1046/j.1460-9568.2003.02499.x</a>.","ieee":"I. Minami, M. Kengaku, S. Smitt, R. Shigemoto, and T. Hirano, “Long-term potentiation of mGluR1 activity by depolarization-induced Homer1a in mouse cerebellar Purkinje neurons,” <i>European Journal of Neuroscience</i>, vol. 17, no. 5. Wiley-Blackwell, pp. 1023–1032, 2003.","short":"I. Minami, M. Kengaku, S. Smitt, R. Shigemoto, T. Hirano, European Journal of Neuroscience 17 (2003) 1023–1032.","ama":"Minami I, Kengaku M, Smitt S, Shigemoto R, Hirano T. Long-term potentiation of mGluR1 activity by depolarization-induced Homer1a in mouse cerebellar Purkinje neurons. <i>European Journal of Neuroscience</i>. 2003;17(5):1023-1032. doi:<a href=\"https://doi.org/10.1046/j.1460-9568.2003.02499.x\">10.1046/j.1460-9568.2003.02499.x</a>","apa":"Minami, I., Kengaku, M., Smitt, S., Shigemoto, R., &#38; Hirano, T. (2003). Long-term potentiation of mGluR1 activity by depolarization-induced Homer1a in mouse cerebellar Purkinje neurons. <i>European Journal of Neuroscience</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1046/j.1460-9568.2003.02499.x\">https://doi.org/10.1046/j.1460-9568.2003.02499.x</a>","mla":"Minami, Itsunari, et al. “Long-Term Potentiation of MGluR1 Activity by Depolarization-Induced Homer1a in Mouse Cerebellar Purkinje Neurons.” <i>European Journal of Neuroscience</i>, vol. 17, no. 5, Wiley-Blackwell, 2003, pp. 1023–32, doi:<a href=\"https://doi.org/10.1046/j.1460-9568.2003.02499.x\">10.1046/j.1460-9568.2003.02499.x</a>."},"type":"journal_article","issue":"5","publisher":"Wiley-Blackwell","date_created":"2018-12-11T11:58:44Z","publication":"European Journal of Neuroscience","month":"03","title":"Long-term potentiation of mGluR1 activity by depolarization-induced Homer1a in mouse cerebellar Purkinje neurons","doi":"10.1046/j.1460-9568.2003.02499.x","author":[{"last_name":"Minami","full_name":"Minami, Itsunari","first_name":"Itsunari"},{"first_name":"Mineko","full_name":"Kengaku, Mineko","last_name":"Kengaku"},{"first_name":"Sillevis","last_name":"Smitt","full_name":"Smitt, Sillevis P"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","orcid":"0000-0001-8761-9444","last_name":"Shigemoto","full_name":"Ryuichi Shigemoto"},{"first_name":"Tomoo","full_name":"Hirano, Tomoo","last_name":"Hirano"}],"_id":"2625","page":"1023 - 1032","date_updated":"2021-01-12T06:58:39Z","publist_id":"4273","publication_status":"published"},{"publisher":"Lippincott, Williams & Wilkins","issue":"7","status":"public","type":"journal_article","citation":{"chicago":"Kaneda, Katsuyuki, Michiko Imanishi, Atsushi Nambu, Ryuichi Shigemoto, and Masahiko Takada. “Differential Expression Patterns of MGluR1α in Monkey Nigral Dopamine Neurons.” <i>Neuroreport</i>. Lippincott, Williams &#38; Wilkins, 2003. <a href=\"https://doi.org/10.1097/01.wnr.0000074344.81633.e4\">https://doi.org/10.1097/01.wnr.0000074344.81633.e4</a>.","ieee":"K. Kaneda, M. Imanishi, A. Nambu, R. Shigemoto, and M. Takada, “Differential expression patterns of mGluR1α in monkey nigral dopamine neurons,” <i>Neuroreport</i>, vol. 14, no. 7. Lippincott, Williams &#38; Wilkins, pp. 947–950, 2003.","ista":"Kaneda K, Imanishi M, Nambu A, Shigemoto R, Takada M. 2003. Differential expression patterns of mGluR1α in monkey nigral dopamine neurons. Neuroreport. 14(7), 947–950.","ama":"Kaneda K, Imanishi M, Nambu A, Shigemoto R, Takada M. Differential expression patterns of mGluR1α in monkey nigral dopamine neurons. <i>Neuroreport</i>. 2003;14(7):947-950. doi:<a href=\"https://doi.org/10.1097/01.wnr.0000074344.81633.e4\">10.1097/01.wnr.0000074344.81633.e4</a>","short":"K. Kaneda, M. Imanishi, A. Nambu, R. Shigemoto, M. Takada, Neuroreport 14 (2003) 947–950.","mla":"Kaneda, Katsuyuki, et al. “Differential Expression Patterns of MGluR1α in Monkey Nigral Dopamine Neurons.” <i>Neuroreport</i>, vol. 14, no. 7, Lippincott, Williams &#38; Wilkins, 2003, pp. 947–50, doi:<a href=\"https://doi.org/10.1097/01.wnr.0000074344.81633.e4\">10.1097/01.wnr.0000074344.81633.e4</a>.","apa":"Kaneda, K., Imanishi, M., Nambu, A., Shigemoto, R., &#38; Takada, M. (2003). Differential expression patterns of mGluR1α in monkey nigral dopamine neurons. <i>Neuroreport</i>. Lippincott, Williams &#38; Wilkins. <a href=\"https://doi.org/10.1097/01.wnr.0000074344.81633.e4\">https://doi.org/10.1097/01.wnr.0000074344.81633.e4</a>"},"quality_controlled":0,"year":"2003","volume":14,"intvolume":"        14","date_published":"2003-05-01T00:00:00Z","day":"01","extern":1,"abstract":[{"text":"The expression pattern of metabotropic glutamate receptor Iα (mGluR1α) was immunohistochemically investigated in substantia nigra dopaminergic neurons of the macaque monkey. In normal monkeys, mGluR1α immunoreactivity was weakly observed in the dorsal tier of the substantia nigra pars compacta (SNc-d) where calbindin-D28k-containing dopaminergic neurons invulnerable to parkinsonian degeneration are specifically located. On the other hand, mGluR1α was strongly expressed in the ventral tier of the substantia nigra pars cornpacta (SNc-v). In monkeys treated with the parkinsonism-inducing drug, I-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), mGluR1α expression was decreased in dopaminergic neurons in the SNc-v that were spared its toxic action. These results suggest that mGluR1α expression may be involved at least partly in the vulnerability of dopaminergic neurons to parkinsonian insults.","lang":"eng"}],"publication_status":"published","publist_id":"4272","date_updated":"2021-01-12T06:58:40Z","page":"947 - 950","_id":"2626","author":[{"first_name":"Katsuyuki","last_name":"Kaneda","full_name":"Kaneda, Katsuyuki"},{"last_name":"Imanishi","full_name":"Imanishi, Michiko","first_name":"Michiko"},{"first_name":"Atsushi","full_name":"Nambu, Atsushi","last_name":"Nambu"},{"first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Ryuichi Shigemoto","orcid":"0000-0001-8761-9444","last_name":"Shigemoto"},{"first_name":"Masahiko","last_name":"Takada","full_name":"Takada, Masahiko"}],"doi":"10.1097/01.wnr.0000074344.81633.e4","month":"05","title":"Differential expression patterns of mGluR1α in monkey nigral dopamine neurons","publication":"Neuroreport","date_created":"2018-12-11T11:58:45Z"},{"volume":300,"year":"2003","quality_controlled":0,"issue":"5621","publisher":"American Association for the Advancement of Science","citation":{"apa":"Kawakami, R., Shinohara, Y., Kato, Y., Sugiyama, H., Shigemoto, R., &#38; Ito, I. (2003). Asymmetrical allocation of NMDA receptor ε2 subunits in hippocampal circuitry. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1082609\">https://doi.org/10.1126/science.1082609</a>","mla":"Kawakami, Ryosuke, et al. “Asymmetrical Allocation of NMDA Receptor Ε2 Subunits in Hippocampal Circuitry.” <i>Science</i>, vol. 300, no. 5621, American Association for the Advancement of Science, 2003, pp. 990–94, doi:<a href=\"https://doi.org/10.1126/science.1082609\">10.1126/science.1082609</a>.","ieee":"R. Kawakami, Y. Shinohara, Y. Kato, H. Sugiyama, R. Shigemoto, and I. Ito, “Asymmetrical allocation of NMDA receptor ε2 subunits in hippocampal circuitry,” <i>Science</i>, vol. 300, no. 5621. American Association for the Advancement of Science, pp. 990–994, 2003.","chicago":"Kawakami, Ryosuke, Yoshiaki Shinohara, Yuichiro Kato, Hiroyuki Sugiyama, Ryuichi Shigemoto, and Isao Ito. “Asymmetrical Allocation of NMDA Receptor Ε2 Subunits in Hippocampal Circuitry.” <i>Science</i>. American Association for the Advancement of Science, 2003. <a href=\"https://doi.org/10.1126/science.1082609\">https://doi.org/10.1126/science.1082609</a>.","ista":"Kawakami R, Shinohara Y, Kato Y, Sugiyama H, Shigemoto R, Ito I. 2003. Asymmetrical allocation of NMDA receptor ε2 subunits in hippocampal circuitry. Science. 300(5621), 990–994.","short":"R. Kawakami, Y. Shinohara, Y. Kato, H. Sugiyama, R. Shigemoto, I. Ito, Science 300 (2003) 990–994.","ama":"Kawakami R, Shinohara Y, Kato Y, Sugiyama H, Shigemoto R, Ito I. Asymmetrical allocation of NMDA receptor ε2 subunits in hippocampal circuitry. <i>Science</i>. 2003;300(5621):990-994. doi:<a href=\"https://doi.org/10.1126/science.1082609\">10.1126/science.1082609</a>"},"type":"journal_article","status":"public","abstract":[{"lang":"eng","text":"Despite its implications for higher order functions of the brain, little is currently known about the molecular basis of left-right asymmetry of the brain. Here we report that synaptic distribution of N-methyl-D-aspartate (NMDA) receptor GluRε2 (NR2B) subunits in the adult mouse hippocampus is asymmetrical between the left and right and between the apical and basal dendrites of single neurons. These asymmetrical allocations of ε2 subunits differentiate the properties of NMDA receptors and synaptic plasticity between the left and right hippocampus. These results provide a molecular basis for the structural and functional asymmetry of the mature brain."}],"day":"09","extern":1,"intvolume":"       300","date_published":"2003-05-09T00:00:00Z","publist_id":"4271","publication_status":"published","publication":"Science","date_created":"2018-12-11T11:58:45Z","month":"05","title":"Asymmetrical allocation of NMDA receptor ε2 subunits in hippocampal circuitry","author":[{"last_name":"Kawakami","full_name":"Kawakami, Ryosuke","first_name":"Ryosuke"},{"full_name":"Shinohara, Yoshiaki","last_name":"Shinohara","first_name":"Yoshiaki"},{"first_name":"Yuichiro","full_name":"Kato, Yuichiro","last_name":"Kato"},{"first_name":"Hiroyuki","full_name":"Sugiyama, Hiroyuki","last_name":"Sugiyama"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","full_name":"Ryuichi Shigemoto","last_name":"Shigemoto","orcid":"0000-0001-8761-9444"},{"first_name":"Isao","last_name":"Ito","full_name":"Ito, Isao"}],"doi":"10.1126/science.1082609","date_updated":"2021-01-12T06:58:40Z","page":"990 - 994","_id":"2627"},{"citation":{"short":"A. Momiyama, R. Silver, M. Häusser, T. Notomi, Y. Wu, R. Shigemoto, S. Cull Candy, Journal of Physiology 549 (2003) 75–92.","ama":"Momiyama A, Silver R, Häusser M, et al. The density of AMPA receptors activated by a transmitter quantum at the climbing fibre - Purkinje cell synapse in immature rats. <i>Journal of Physiology</i>. 2003;549(1):75-92. doi:<a href=\"https://doi.org/10.1113/jphysiol.2002.033472\">10.1113/jphysiol.2002.033472</a>","ista":"Momiyama A, Silver R, Häusser M, Notomi T, Wu Y, Shigemoto R, Cull Candy S. 2003. The density of AMPA receptors activated by a transmitter quantum at the climbing fibre - Purkinje cell synapse in immature rats. Journal of Physiology. 549(1), 75–92.","ieee":"A. Momiyama <i>et al.</i>, “The density of AMPA receptors activated by a transmitter quantum at the climbing fibre - Purkinje cell synapse in immature rats,” <i>Journal of Physiology</i>, vol. 549, no. 1. Wiley-Blackwell, pp. 75–92, 2003.","chicago":"Momiyama, Akiko, Rachel Silver, Michael Häusser, Takuya Notomi, Yue Wu, Ryuichi Shigemoto, and Stuart Cull Candy. “The Density of AMPA Receptors Activated by a Transmitter Quantum at the Climbing Fibre - Purkinje Cell Synapse in Immature Rats.” <i>Journal of Physiology</i>. Wiley-Blackwell, 2003. <a href=\"https://doi.org/10.1113/jphysiol.2002.033472\">https://doi.org/10.1113/jphysiol.2002.033472</a>.","apa":"Momiyama, A., Silver, R., Häusser, M., Notomi, T., Wu, Y., Shigemoto, R., &#38; Cull Candy, S. (2003). The density of AMPA receptors activated by a transmitter quantum at the climbing fibre - Purkinje cell synapse in immature rats. <i>Journal of Physiology</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1113/jphysiol.2002.033472\">https://doi.org/10.1113/jphysiol.2002.033472</a>","mla":"Momiyama, Akiko, et al. “The Density of AMPA Receptors Activated by a Transmitter Quantum at the Climbing Fibre - Purkinje Cell Synapse in Immature Rats.” <i>Journal of Physiology</i>, vol. 549, no. 1, Wiley-Blackwell, 2003, pp. 75–92, doi:<a href=\"https://doi.org/10.1113/jphysiol.2002.033472\">10.1113/jphysiol.2002.033472</a>."},"type":"journal_article","status":"public","issue":"1","publisher":"Wiley-Blackwell","quality_controlled":0,"year":"2003","volume":549,"date_published":"2003-05-15T00:00:00Z","intvolume":"       549","day":"15","extern":1,"abstract":[{"lang":"eng","text":"We aimed to estimate the number of AMPA receptors (AMPARs) bound by the quantal transmitter packet, their single-channel conductance and their density in the postsynaptic membrane at cerebellar Purkinje cell synapses. The synaptic and extrasynaptic AMPARs were examined in Purkinje cells in 2- to 4-day-old rats, when they receive synaptic inputs solely from climbing fibres (CFs). Evoked CF EPSCs and whole-cell AMPA currents displayed roughly linear current-voltage relationships, consistent with the presence of GluR2 subunits in synaptic and extrasynaptic AMPARs. The mean quantal size, estimated from the miniature EPSCs (MEPSCs), was ∼300 pS. Peak-scaled non-stationary fluctuation analysis of spontaneous EPSCs and MEPSCs gave a weighted-mean synaptic channel conductance of ∼5 pS (∼7 pS when corrected for filtering). By applying non-stationary fluctuation analysis to extrasynaptic currents activated by brief glutamate pulses (5 mM), we also obtained a small single-channel conductance estimate for extrasynaptic AMPARs (∼11 pS). This approach allowed us to obtain a maximum open probability (Po,max) value for the extrasynaptic receptors (Po,max = 0.72). Directly resolved extrasynaptic channel openings in the continued presence of glutamate exhibited clear multiple-conductance levels. The mean area of the postsynaptic density (PSD) of these synapses was 0.074 μm2, measured by reconstructing electron-microscopic (EM) serial sections. Postembedding immunogold labelling by anti-GluR2/3 antibody revealed that AMPARs are localised in PSDs. From these data and by simulating error factors, we estimate that at least 66 AMPARs are bound by a quantal transmitter packet at CF-Purkinje cell synapses, and the receptors are packed at a minimum density of ∼900 μm-2 in the postsynaptic membrane."}],"publication_status":"published","publist_id":"4270","_id":"2628","date_updated":"2021-01-12T06:58:40Z","page":"75 - 92","doi":"10.1113/jphysiol.2002.033472","author":[{"first_name":"Akiko","full_name":"Momiyama, Akiko","last_name":"Momiyama"},{"last_name":"Silver","full_name":"Silver, Rachel A","first_name":"Rachel"},{"first_name":"Michael","last_name":"Häusser","full_name":"Häusser, Michael A"},{"first_name":"Takuya","full_name":"Notomi, Takuya","last_name":"Notomi"},{"full_name":"Wu, Yue","last_name":"Wu","first_name":"Yue"},{"last_name":"Shigemoto","orcid":"0000-0001-8761-9444","full_name":"Ryuichi Shigemoto","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Stuart","full_name":"Cull-Candy, Stuart G","last_name":"Cull Candy"}],"title":"The density of AMPA receptors activated by a transmitter quantum at the climbing fibre - Purkinje cell synapse in immature rats","month":"05","date_created":"2018-12-11T11:58:45Z","publication":"Journal of Physiology"},{"date_created":"2018-12-11T11:58:46Z","publication":"European Journal of Neuroscience","month":"06","title":"High level of mGluR7 in the presynaptic active zones of select populations of GABAergic terminals innervating interneurons in the rat hippocampus","doi":"10.1046/j.1460-9568.2003.02697.x","author":[{"first_name":"Péter","full_name":"Somogyi, Péter","last_name":"Somogyi"},{"full_name":"Dalezios, Yannis","last_name":"Dalezios","first_name":"Yannis"},{"first_name":"Rafael","full_name":"Luján, Rafael","last_name":"Luján"},{"last_name":"Roberts","full_name":"Roberts, John D","first_name":"John"},{"full_name":"Watanabe, Masahiko","last_name":"Watanabe","first_name":"Masahiko"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","last_name":"Shigemoto","orcid":"0000-0001-8761-9444","full_name":"Ryuichi Shigemoto"}],"_id":"2629","date_updated":"2021-01-12T06:58:41Z","page":"2503 - 2520","publist_id":"4269","publication_status":"published","abstract":[{"lang":"eng","text":"The release of neurotransmitters is modulated by presynaptic metabotropic glutamate receptors (mGluRs), which show a highly selective expression and subcellular location in glutamatergic terminals in the hippocampus. Using immunocytochemistry, we investigated whether one of the receptors, mGluR7, whose level of expression is governed by the postsynaptic target, was present in GABAergic terminals and whether such terminals targeted particular cells. A total of 165 interneuron dendritic profiles receiving 466 synapses (82% mGluR7a-positive) were analysed. The presynaptic active zones of most GAD-(77%) or GABA-positive (94%) synaptic boutons on interneurons innervated by mGluR7a-enriched glutamatergic terminals (mGluR7a-decorated) were immunopositive for mGluR7a. GABAergic terminals on pyramidal cells and most other interneurons in str. oriens were mGluR7a-immunonegative. The mGluR7a-decorated cells were mostly somatostatin- and mGluR1α-immunopositive neurons in str. oriens and the alveus. Their GABAergic input mainly originated from VIP-positive terminals, 90% of which expressed high levels of mGluR7a in the presynaptic active zone. Parvalbumin-positive synaptic terminals were rare on mGluR7a-decorated cells, but on these neurons 73% of them were mGluR7a-immunopositive. Some type II synapses innervating interneurons were immunopositive for mGluR7b, as were some type I synapses. Because not all target cells of VIP-positive neurons are known it has not been possible to determine whether mGluR7 is expressed in a target-cell-specific manner in the terminals of single GABAergic cells. The activation of mGluR7 may decrease GABA release to mGluR7-decorated cells at times of high pyramidal cell activity, which elevates extracellular glutamate levels. Alternatively, the presynaptic receptor may be activated by as yet unidentified endogenous ligands released by the GABAergic terminals or the postsynaptic dendrites."}],"extern":1,"day":"01","date_published":"2003-06-01T00:00:00Z","intvolume":"        17","volume":17,"year":"2003","quality_controlled":0,"citation":{"ista":"Somogyi P, Dalezios Y, Luján R, Roberts J, Watanabe M, Shigemoto R. 2003. High level of mGluR7 in the presynaptic active zones of select populations of GABAergic terminals innervating interneurons in the rat hippocampus. European Journal of Neuroscience. 17(12), 2503–2520.","chicago":"Somogyi, Péter, Yannis Dalezios, Rafael Luján, John Roberts, Masahiko Watanabe, and Ryuichi Shigemoto. “High Level of MGluR7 in the Presynaptic Active Zones of Select Populations of GABAergic Terminals Innervating Interneurons in the Rat Hippocampus.” <i>European Journal of Neuroscience</i>. Wiley-Blackwell, 2003. <a href=\"https://doi.org/10.1046/j.1460-9568.2003.02697.x\">https://doi.org/10.1046/j.1460-9568.2003.02697.x</a>.","ieee":"P. Somogyi, Y. Dalezios, R. Luján, J. Roberts, M. Watanabe, and R. Shigemoto, “High level of mGluR7 in the presynaptic active zones of select populations of GABAergic terminals innervating interneurons in the rat hippocampus,” <i>European Journal of Neuroscience</i>, vol. 17, no. 12. Wiley-Blackwell, pp. 2503–2520, 2003.","ama":"Somogyi P, Dalezios Y, Luján R, Roberts J, Watanabe M, Shigemoto R. High level of mGluR7 in the presynaptic active zones of select populations of GABAergic terminals innervating interneurons in the rat hippocampus. <i>European Journal of Neuroscience</i>. 2003;17(12):2503-2520. doi:<a href=\"https://doi.org/10.1046/j.1460-9568.2003.02697.x\">10.1046/j.1460-9568.2003.02697.x</a>","short":"P. Somogyi, Y. Dalezios, R. Luján, J. Roberts, M. Watanabe, R. Shigemoto, European Journal of Neuroscience 17 (2003) 2503–2520.","apa":"Somogyi, P., Dalezios, Y., Luján, R., Roberts, J., Watanabe, M., &#38; Shigemoto, R. (2003). High level of mGluR7 in the presynaptic active zones of select populations of GABAergic terminals innervating interneurons in the rat hippocampus. <i>European Journal of Neuroscience</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1046/j.1460-9568.2003.02697.x\">https://doi.org/10.1046/j.1460-9568.2003.02697.x</a>","mla":"Somogyi, Péter, et al. “High Level of MGluR7 in the Presynaptic Active Zones of Select Populations of GABAergic Terminals Innervating Interneurons in the Rat Hippocampus.” <i>European Journal of Neuroscience</i>, vol. 17, no. 12, Wiley-Blackwell, 2003, pp. 2503–20, doi:<a href=\"https://doi.org/10.1046/j.1460-9568.2003.02697.x\">10.1046/j.1460-9568.2003.02697.x</a>."},"status":"public","type":"journal_article","publisher":"Wiley-Blackwell","issue":"12"},{"publication_status":"published","publist_id":"4267","_id":"2630","date_updated":"2021-01-12T06:58:41Z","page":"29 - 35","doi":"10.1007/s00441-003-0740-2","author":[{"first_name":"Takashi","last_name":"Toyono","full_name":"Toyono, Takashi"},{"last_name":"Seta","full_name":"Seta, Yuji","first_name":"Yuji"},{"last_name":"Kataoka","full_name":"Kataoka, Shinji","first_name":"Shinji"},{"full_name":"Kawano, Shintaro","last_name":"Kawano","first_name":"Shintaro"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","full_name":"Ryuichi Shigemoto","last_name":"Shigemoto","orcid":"0000-0001-8761-9444"},{"full_name":"Toyoshima, Kuniaki","last_name":"Toyoshima","first_name":"Kuniaki"}],"title":"Expression of metabotropic glutamate receptor group I in rat gustatory papillae","month":"07","date_created":"2018-12-11T11:58:46Z","publication":"Cell and Tissue Research","type":"journal_article","status":"public","citation":{"short":"T. Toyono, Y. Seta, S. Kataoka, S. Kawano, R. Shigemoto, K. Toyoshima, Cell and Tissue Research 313 (2003) 29–35.","ama":"Toyono T, Seta Y, Kataoka S, Kawano S, Shigemoto R, Toyoshima K. Expression of metabotropic glutamate receptor group I in rat gustatory papillae. <i>Cell and Tissue Research</i>. 2003;313(1):29-35. doi:<a href=\"https://doi.org/10.1007/s00441-003-0740-2\">10.1007/s00441-003-0740-2</a>","ista":"Toyono T, Seta Y, Kataoka S, Kawano S, Shigemoto R, Toyoshima K. 2003. Expression of metabotropic glutamate receptor group I in rat gustatory papillae. Cell and Tissue Research. 313(1), 29–35.","ieee":"T. Toyono, Y. Seta, S. Kataoka, S. Kawano, R. Shigemoto, and K. Toyoshima, “Expression of metabotropic glutamate receptor group I in rat gustatory papillae,” <i>Cell and Tissue Research</i>, vol. 313, no. 1. Springer, pp. 29–35, 2003.","chicago":"Toyono, Takashi, Yuji Seta, Shinji Kataoka, Shintaro Kawano, Ryuichi Shigemoto, and Kuniaki Toyoshima. “Expression of Metabotropic Glutamate Receptor Group I in Rat Gustatory Papillae.” <i>Cell and Tissue Research</i>. Springer, 2003. <a href=\"https://doi.org/10.1007/s00441-003-0740-2\">https://doi.org/10.1007/s00441-003-0740-2</a>.","apa":"Toyono, T., Seta, Y., Kataoka, S., Kawano, S., Shigemoto, R., &#38; Toyoshima, K. (2003). Expression of metabotropic glutamate receptor group I in rat gustatory papillae. <i>Cell and Tissue Research</i>. Springer. <a href=\"https://doi.org/10.1007/s00441-003-0740-2\">https://doi.org/10.1007/s00441-003-0740-2</a>","mla":"Toyono, Takashi, et al. “Expression of Metabotropic Glutamate Receptor Group I in Rat Gustatory Papillae.” <i>Cell and Tissue Research</i>, vol. 313, no. 1, Springer, 2003, pp. 29–35, doi:<a href=\"https://doi.org/10.1007/s00441-003-0740-2\">10.1007/s00441-003-0740-2</a>."},"publisher":"Springer","issue":"1","quality_controlled":0,"year":"2003","volume":313,"date_published":"2003-07-01T00:00:00Z","intvolume":"       313","extern":1,"day":"01","abstract":[{"text":"Taste-metabotropic glutamate receptor 4 (taste-mGluR4) and the heteromers of T1R1 and T1R3 are candidate receptors involved in the sense of umami (monosodium glutamate) taste. Although the expression of group III mGluRs (taste-mGluR4) has been demonstrated in taste tissues, no mention has been made of the expression of group I mGluRs (mGluR1 and mGluR5) in taste tissues. We examined the expression of mGluR1 and mGluR5 in rat gustatory tissues by using reverse transcription-polymerase chain reaction (RT-PCR), in situ hybridization, immunohistochemistry and immunoelectron microscopy. RT-PCR assay showed that mGluR1α and mGluR1β mRNAs were expressed in circumvallate papillae, but mGluR5 mRNA was not expressed. The positive signals of mGluR1 mRNA were detected only in circumvallate taste buds by in situ hybridization analysis. In cryosections of fungiform, foliate and circumvallate papillae, the antibody against mGluRla gave intense labeling on the taste hairs in all taste pores examined. In the developing taste buds, the positive signals of mGluR1α in taste hairs gradually increased with the increase in number of taste bud cells. These results show that, in addition to taste-mGluR4 and the heteromer of T1R1 and T1R3, mGluR1α may function as a receptor for glutamate (umami) taste sensation.","lang":"eng"}]},{"title":"Subtype-specific coupling with ADP-ribosyl cyclase of metabotropic glutamate receptors in retina, cervical superior ganglion and NG108-15 cells","month":"06","publication":"Journal of Neurochemistry","date_created":"2018-12-11T11:58:46Z","page":"1148 - 1158","date_updated":"2021-01-12T06:58:42Z","_id":"2631","author":[{"full_name":"Higashida, Haruhiro","last_name":"Higashida","first_name":"Haruhiro"},{"full_name":"Zhang, Jia-Sheng","last_name":"Zhang","first_name":"Jia"},{"last_name":"Mochida","full_name":"Mochida, Sumiko","first_name":"Sumiko"},{"first_name":"Xiao","full_name":"Chen, Xiao-Liang","last_name":"Chen"},{"first_name":"Yeonsook","last_name":"Shin","full_name":"Shin, Yeonsook"},{"first_name":"Mami","full_name":"Noda, Mami","last_name":"Noda"},{"first_name":"Kazi","full_name":"Hossain, Kazi Z","last_name":"Hossain"},{"first_name":"Naoto","full_name":"Hoshi, Naoto","last_name":"Hoshi"},{"first_name":"Minako","full_name":"Hashii, Minako","last_name":"Hashii"},{"last_name":"Shigemoto","orcid":"0000-0001-8761-9444","full_name":"Ryuichi Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi"},{"first_name":"Shigetada","last_name":"Nakanishi","full_name":"Nakanishi, Shigetada"},{"full_name":"Fukuda, Yutaka","last_name":"Fukuda","first_name":"Yutaka"},{"last_name":"Yokoyama","full_name":"Yokoyama, Shigeru","first_name":"Shigeru"}],"doi":"10.1046/j.1471-4159.2003.01751.x","publist_id":"4268","publication_status":"published","day":"01","extern":1,"abstract":[{"lang":"eng","text":"Cyclic ADP-ribose (cADP-ribose) is a putative second messenger or modulator. However, the role of cADP-ribose in the downstream signals of the metabotropic glutamate receptors (mGluRs) is unclear. Here, we show that glutamate stimulates ADP-ribosyl cyclase activity in rat or mouse crude membranes of retina via group III mGluRs or in superior cervical ganglion via group I mGluRs. The retina of mGluR6-deficient mice showed no increase in the ADP-ribosyl cyclase level in response to glutamate. GTP enhanced the initial rate of basal and glutamate-stimulated cyclase activity. GTP-γ-S also stimulated basal activity. To determine whether the coupling mode of mGluRs to ADP-ribosyl cyclase is a feature common to individual cloned mGluRs, we expressed each mGluR subtype in NG108-15 neuroblastoma x glioma hybrid cells. The glutamate-induced stimulation of the cyclase occurs preferentially in NG108-15 cells over-expressing mGluRs1, 3, 5, and 6. Cells expressing mGluR2 or mGluRs4 and 7 exhibit inhibition or no coupling, respectively. Glutamate-induced activation or inhibition of the cyclase activity was eliminated after pre-treatment with cholera or pertussis toxin, respectively. Thus, the subtype-specific coupling of mGluRs to ADP-ribosyl cyclase via G proteins suggests that some glutamate-evoked neuronal functions are mediated by cADP-ribose."}],"intvolume":"        85","date_published":"2003-06-01T00:00:00Z","year":"2003","volume":85,"issue":"5","publisher":"Wiley-Blackwell","citation":{"short":"H. Higashida, J. Zhang, S. Mochida, X. Chen, Y. Shin, M. Noda, K. Hossain, N. Hoshi, M. Hashii, R. Shigemoto, S. Nakanishi, Y. Fukuda, S. Yokoyama, Journal of Neurochemistry 85 (2003) 1148–1158.","ama":"Higashida H, Zhang J, Mochida S, et al. Subtype-specific coupling with ADP-ribosyl cyclase of metabotropic glutamate receptors in retina, cervical superior ganglion and NG108-15 cells. <i>Journal of Neurochemistry</i>. 2003;85(5):1148-1158. doi:<a href=\"https://doi.org/10.1046/j.1471-4159.2003.01751.x\">10.1046/j.1471-4159.2003.01751.x</a>","ista":"Higashida H, Zhang J, Mochida S, Chen X, Shin Y, Noda M, Hossain K, Hoshi N, Hashii M, Shigemoto R, Nakanishi S, Fukuda Y, Yokoyama S. 2003. Subtype-specific coupling with ADP-ribosyl cyclase of metabotropic glutamate receptors in retina, cervical superior ganglion and NG108-15 cells. Journal of Neurochemistry. 85(5), 1148–1158.","chicago":"Higashida, Haruhiro, Jia Zhang, Sumiko Mochida, Xiao Chen, Yeonsook Shin, Mami Noda, Kazi Hossain, et al. “Subtype-Specific Coupling with ADP-Ribosyl Cyclase of Metabotropic Glutamate Receptors in Retina, Cervical Superior Ganglion and NG108-15 Cells.” <i>Journal of Neurochemistry</i>. Wiley-Blackwell, 2003. <a href=\"https://doi.org/10.1046/j.1471-4159.2003.01751.x\">https://doi.org/10.1046/j.1471-4159.2003.01751.x</a>.","ieee":"H. Higashida <i>et al.</i>, “Subtype-specific coupling with ADP-ribosyl cyclase of metabotropic glutamate receptors in retina, cervical superior ganglion and NG108-15 cells,” <i>Journal of Neurochemistry</i>, vol. 85, no. 5. Wiley-Blackwell, pp. 1148–1158, 2003.","apa":"Higashida, H., Zhang, J., Mochida, S., Chen, X., Shin, Y., Noda, M., … Yokoyama, S. (2003). Subtype-specific coupling with ADP-ribosyl cyclase of metabotropic glutamate receptors in retina, cervical superior ganglion and NG108-15 cells. <i>Journal of Neurochemistry</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1046/j.1471-4159.2003.01751.x\">https://doi.org/10.1046/j.1471-4159.2003.01751.x</a>","mla":"Higashida, Haruhiro, et al. “Subtype-Specific Coupling with ADP-Ribosyl Cyclase of Metabotropic Glutamate Receptors in Retina, Cervical Superior Ganglion and NG108-15 Cells.” <i>Journal of Neurochemistry</i>, vol. 85, no. 5, Wiley-Blackwell, 2003, pp. 1148–58, doi:<a href=\"https://doi.org/10.1046/j.1471-4159.2003.01751.x\">10.1046/j.1471-4159.2003.01751.x</a>."},"type":"journal_article","status":"public","quality_controlled":0},{"publist_id":"4266","publication_status":"published","month":"07","title":"Cell type-dependent expression of HCN1 in the main olfactory bulb","date_created":"2018-12-11T11:58:47Z","publication":"European Journal of Neuroscience","_id":"2632","page":"344 - 354","date_updated":"2021-01-12T06:58:42Z","doi":"10.1046/j.1460-9568.2003.02756.x","author":[{"full_name":"Holderith, Noémi B","last_name":"Holderith","first_name":"Noémi"},{"last_name":"Shigemoto","orcid":"0000-0001-8761-9444","full_name":"Ryuichi Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi"},{"first_name":"Zoltán","last_name":"Nusser","full_name":"Nusser, Zoltán"}],"year":"2003","volume":18,"citation":{"ama":"Holderith N, Shigemoto R, Nusser Z. Cell type-dependent expression of HCN1 in the main olfactory bulb. <i>European Journal of Neuroscience</i>. 2003;18(2):344-354. doi:<a href=\"https://doi.org/10.1046/j.1460-9568.2003.02756.x\">10.1046/j.1460-9568.2003.02756.x</a>","short":"N. Holderith, R. Shigemoto, Z. Nusser, European Journal of Neuroscience 18 (2003) 344–354.","ieee":"N. Holderith, R. Shigemoto, and Z. Nusser, “Cell type-dependent expression of HCN1 in the main olfactory bulb,” <i>European Journal of Neuroscience</i>, vol. 18, no. 2. Wiley-Blackwell, pp. 344–354, 2003.","chicago":"Holderith, Noémi, Ryuichi Shigemoto, and Zoltán Nusser. “Cell Type-Dependent Expression of HCN1 in the Main Olfactory Bulb.” <i>European Journal of Neuroscience</i>. Wiley-Blackwell, 2003. <a href=\"https://doi.org/10.1046/j.1460-9568.2003.02756.x\">https://doi.org/10.1046/j.1460-9568.2003.02756.x</a>.","ista":"Holderith N, Shigemoto R, Nusser Z. 2003. Cell type-dependent expression of HCN1 in the main olfactory bulb. European Journal of Neuroscience. 18(2), 344–354.","apa":"Holderith, N., Shigemoto, R., &#38; Nusser, Z. (2003). Cell type-dependent expression of HCN1 in the main olfactory bulb. <i>European Journal of Neuroscience</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1046/j.1460-9568.2003.02756.x\">https://doi.org/10.1046/j.1460-9568.2003.02756.x</a>","mla":"Holderith, Noémi, et al. “Cell Type-Dependent Expression of HCN1 in the Main Olfactory Bulb.” <i>European Journal of Neuroscience</i>, vol. 18, no. 2, Wiley-Blackwell, 2003, pp. 344–54, doi:<a href=\"https://doi.org/10.1046/j.1460-9568.2003.02756.x\">10.1046/j.1460-9568.2003.02756.x</a>."},"type":"journal_article","status":"public","issue":"2","publisher":"Wiley-Blackwell","quality_controlled":0,"extern":1,"day":"01","abstract":[{"lang":"eng","text":"In many brain regions, hyperpolarization-activated cationic currents (Ih) are involved in the generation of rhythmic activities, but the role of Ih in olfactory oscillations remains unclear. Knowledge of the cellular and subcellular distributions of hyperpolarization-activated and cyclic nucleotide-gated channel (HCN) subunits is necessary for understanding the role of Ih in olfactory network activities. Using light microscopic immunocytochemistry, we demonstrate strong HCN1 labelling of the glomerular layer and moderate staining of granule cell, internal and external plexiform layers of the rat main olfactory bulb. In the glomerular layer, among many unlabelled neurons, two distinct subpopulations of juxtaglomerular cells are labelled. Approximately 10% of the juxtaglomerular cells strongly express HCN1. These small diameter cells are immunoreactive for GABA and comprise a subpopulation of periglomerular cells. An additional subset of juxtaglomerular cells (≈ 1%) expresses low levels of HCN1. They are large in diameter, GABA immunonegative but immunopositive for vesicular glutamate transporter 2, characterizing them as external tufted cells. Quantitative immunogold localization revealed that the somatic plasma membranes of periglomerular cells contain approximately four times more HCN1 labelling than those of external tufted cells. Unlike in cortical pyramidal cells, immunogold density for HCN1 does not significantly differ in somatic and dendritic plasma membranes of external tufted cells, indicating that post-synaptic potentials arriving at proximal and distal dendrites are modulated by the same density of I h. Our results demonstrate a cell type-dependent expression of HCN1 in the olfactory bulb and predict a differential contribution of distinct juxtaglomerular cell types to network oscillations."}],"date_published":"2003-07-01T00:00:00Z","intvolume":"        18"},{"volume":278,"year":"2003","quality_controlled":0,"citation":{"mla":"Millán, Carmelo, et al. “Co-Expression of Metabotropic Glutamate Receptor 7 and N-Type Ca2+ Channels in Single Cerebrocortical Nerve Terminals of Adult Rats.” <i>Journal of Biological Chemistry</i>, vol. 278, no. 26, American Society for Biochemistry and Molecular Biology, 2003, pp. 23955–62, doi:<a href=\"https://doi.org/10.1074/jbc.M211471200\">10.1074/jbc.M211471200</a>.","apa":"Millán, C., Castro, E., Torres, M., Shigemoto, R., &#38; Sánchez Prieto, J. (2003). Co-expression of metabotropic glutamate receptor 7 and N-type Ca2+ channels in single cerebrocortical nerve terminals of adult rats. <i>Journal of Biological Chemistry</i>. American Society for Biochemistry and Molecular Biology. <a href=\"https://doi.org/10.1074/jbc.M211471200\">https://doi.org/10.1074/jbc.M211471200</a>","short":"C. Millán, E. Castro, M. Torres, R. Shigemoto, J. Sánchez Prieto, Journal of Biological Chemistry 278 (2003) 23955–23962.","ama":"Millán C, Castro E, Torres M, Shigemoto R, Sánchez Prieto J. Co-expression of metabotropic glutamate receptor 7 and N-type Ca2+ channels in single cerebrocortical nerve terminals of adult rats. <i>Journal of Biological Chemistry</i>. 2003;278(26):23955-23962. doi:<a href=\"https://doi.org/10.1074/jbc.M211471200\">10.1074/jbc.M211471200</a>","ista":"Millán C, Castro E, Torres M, Shigemoto R, Sánchez Prieto J. 2003. Co-expression of metabotropic glutamate receptor 7 and N-type Ca2+ channels in single cerebrocortical nerve terminals of adult rats. Journal of Biological Chemistry. 278(26), 23955–23962.","ieee":"C. Millán, E. Castro, M. Torres, R. Shigemoto, and J. Sánchez Prieto, “Co-expression of metabotropic glutamate receptor 7 and N-type Ca2+ channels in single cerebrocortical nerve terminals of adult rats,” <i>Journal of Biological Chemistry</i>, vol. 278, no. 26. American Society for Biochemistry and Molecular Biology, pp. 23955–23962, 2003.","chicago":"Millán, Carmelo, Enrique Castro, Magdalena Torres, Ryuichi Shigemoto, and José Sánchez Prieto. “Co-Expression of Metabotropic Glutamate Receptor 7 and N-Type Ca2+ Channels in Single Cerebrocortical Nerve Terminals of Adult Rats.” <i>Journal of Biological Chemistry</i>. American Society for Biochemistry and Molecular Biology, 2003. <a href=\"https://doi.org/10.1074/jbc.M211471200\">https://doi.org/10.1074/jbc.M211471200</a>."},"status":"public","type":"journal_article","publisher":"American Society for Biochemistry and Molecular Biology","issue":"26","abstract":[{"text":"The modulation of calcium channels by metabotropic glutamate receptors (mGluRs) is a key event in the fine-tuning of neurotransmitter release. Here we report that, in cerebrocortical nerve terminals of adult rats, the inhibition of glutamate release is mediated by mGluR7. In this preparation, the major component of glutamate release is supported by P/Q-type Ca2+ channels (72.7%). However, mGluR7 selectively reduced the release component that is associated with N-type Ca2+ channels (29.9%). Inhibition of P/Q channels by mGluR7 is not masked by the higher efficiency of these channels in driving glutamate release when compared with N-type channels. Thus, activation of mGluR7 failed to reduce the release associated with P/Q channels when the extracellular calcium concentration, ([Ca2+]o), was reduced from 1.3 to 0.5 mM. Through Ca2+ imaging, we show that Ca2+ channels are distributed in a heterogeneous manner in individual nerve terminals. Indeed, in this preparation, nerve terminals were observed that contain N-type (31.1%; conotoxin GVIA-sensitive) or P/Q-type (64.3%; agatoxin IVA-sensitive) channels or that were insensitive to these two toxins (4.6%). Interestingly, the great majority of the responses to L-AP4 (95.4%) were observed in nerve terminals containing N-type channels. This specific co-localization of mGluR7 and N-type Ca2+-channels could explain the failure of the receptor to inhibit the P/Q channel-associated release component and also reveal the existence of specific targeting mechanisms to localize the two proteins in the same nerve terminal subset.","lang":"eng"}],"extern":1,"day":"27","date_published":"2003-07-27T00:00:00Z","intvolume":"       278","publist_id":"4265","publication_status":"published","date_created":"2018-12-11T11:58:47Z","publication":"Journal of Biological Chemistry","month":"07","title":"Co-expression of metabotropic glutamate receptor 7 and N-type Ca2+ channels in single cerebrocortical nerve terminals of adult rats","doi":"10.1074/jbc.M211471200","author":[{"last_name":"Millán","full_name":"Millán, Carmelo","first_name":"Carmelo"},{"full_name":"Castro, Enrique G","last_name":"Castro","first_name":"Enrique"},{"first_name":"Magdalena","last_name":"Torres","full_name":"Torres, Magdalena"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","orcid":"0000-0001-8761-9444","last_name":"Shigemoto","full_name":"Ryuichi Shigemoto"},{"first_name":"José","full_name":"Sánchez-Prieto, José","last_name":"Sánchez Prieto"}],"_id":"2633","date_updated":"2021-01-12T06:58:42Z","page":"23955 - 23962"},{"publist_id":"4264","publication_status":"published","month":"09","title":"Blockade of GABAB receptors alters the tangential migration of cortical neurons","publication":"Cerebral Cortex","date_created":"2018-12-11T11:58:47Z","date_updated":"2021-01-12T06:58:43Z","page":"932 - 942","_id":"2634","author":[{"full_name":"López-Bendito, Guillermina","last_name":"López Bendito","first_name":"Guillermina"},{"first_name":"Rafael","full_name":"Luján, Rafael","last_name":"Luján"},{"full_name":"Ryuichi Shigemoto","last_name":"Shigemoto","orcid":"0000-0001-8761-9444","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi"},{"last_name":"Ganter","full_name":"Ganter, Paul","first_name":"Paul"},{"last_name":"Paulsen","full_name":"Paulsen, Ole","first_name":"Ole"},{"first_name":"Zoltán","last_name":"Molnár","full_name":"Molnár, Zoltán"}],"doi":"10.1093/cercor/13.9.932","year":"2003","volume":13,"issue":"9","publisher":"Oxford University Press","status":"public","citation":{"ama":"López Bendito G, Luján R, Shigemoto R, Ganter P, Paulsen O, Molnár Z. Blockade of GABAB receptors alters the tangential migration of cortical neurons. <i>Cerebral Cortex</i>. 2003;13(9):932-942. doi:<a href=\"https://doi.org/10.1093/cercor/13.9.932\">10.1093/cercor/13.9.932</a>","short":"G. López Bendito, R. Luján, R. Shigemoto, P. Ganter, O. Paulsen, Z. Molnár, Cerebral Cortex 13 (2003) 932–942.","ista":"López Bendito G, Luján R, Shigemoto R, Ganter P, Paulsen O, Molnár Z. 2003. Blockade of GABAB receptors alters the tangential migration of cortical neurons. Cerebral Cortex. 13(9), 932–942.","chicago":"López Bendito, Guillermina, Rafael Luján, Ryuichi Shigemoto, Paul Ganter, Ole Paulsen, and Zoltán Molnár. “Blockade of GABAB Receptors Alters the Tangential Migration of Cortical Neurons.” <i>Cerebral Cortex</i>. Oxford University Press, 2003. <a href=\"https://doi.org/10.1093/cercor/13.9.932\">https://doi.org/10.1093/cercor/13.9.932</a>.","ieee":"G. López Bendito, R. Luján, R. Shigemoto, P. Ganter, O. Paulsen, and Z. Molnár, “Blockade of GABAB receptors alters the tangential migration of cortical neurons,” <i>Cerebral Cortex</i>, vol. 13, no. 9. Oxford University Press, pp. 932–942, 2003.","apa":"López Bendito, G., Luján, R., Shigemoto, R., Ganter, P., Paulsen, O., &#38; Molnár, Z. (2003). Blockade of GABAB receptors alters the tangential migration of cortical neurons. <i>Cerebral Cortex</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/cercor/13.9.932\">https://doi.org/10.1093/cercor/13.9.932</a>","mla":"López Bendito, Guillermina, et al. “Blockade of GABAB Receptors Alters the Tangential Migration of Cortical Neurons.” <i>Cerebral Cortex</i>, vol. 13, no. 9, Oxford University Press, 2003, pp. 932–42, doi:<a href=\"https://doi.org/10.1093/cercor/13.9.932\">10.1093/cercor/13.9.932</a>."},"type":"journal_article","quality_controlled":0,"extern":1,"day":"01","abstract":[{"lang":"eng","text":"To better understand the role of neurotransmitter receptors in neuronal differentiation and maturation a detailed knowledge of their identity, location and function in the plasma membrane of specific neuronal populations during development is required. Combining pre-embedding immunocytochemistry with cell tracking in embryonic brain slice cultures we show that virtually all neurons (∼98%) migrating through the lower intermediate zone (LIZ) on their way from the medial ganglionic eminence to the cerebral cortex, express GABA BR1. Blockade of GABABRs with a specific antagonist, CGP52432, resulted in a concentration-dependent accumulation of these tangentially migrating neurons in the ventricular/subventricular zones (VZ/SVZ) of the cortex and fewer cells were observed in the cortical plate/marginal zone (CP/MZ) and LIZ. Moreover, they had significantly shorter leading processes compared with similar migrating cells in control slices. Electrophysiological recording in LIZ and CP cells revealed no direct effect of either CGP52432 or the GABABR agonist, baclofen, on resting membrane properties suggesting that the effect of CGP52432 on migration might be mediated through a metabotropic action or the regulation of release of factors controlling migration. These results suggest that GABABRs have an important modulatory role in the migration of cortical interneurons."}],"intvolume":"        13","date_published":"2003-09-01T00:00:00Z"},{"date_published":"2003-12-03T00:00:00Z","intvolume":"        23","abstract":[{"lang":"eng","text":"Metabotropic GABAB receptors mediate slow inhibitory effects presynaptically and postsynaptically. Using preembedding immunohistochemical methods combined with quantitative analysis of GABAB receptor subunit immunoreactivity, this study provides a detailed description of the cellular and subcellular localization of GABAB1a/b and GABA B2 in the rat hippocampus. At the light microscopic level, an overlapping distribution of GABAB1a/b and GABAB2 was revealed in the dendritic layers of the hippocampus. In addition, expression of the GABAB1a/b subunit was found in somata of CA1 pyramidal cells and of a subset of GABAergic interneurons. At the electron microscopic level, immunoreactivity for both subunits was observed on presynaptic and, more abundantly, on postsynaptic elements. Presynaptically, subunits were mainly detected in the extrasynaptic membrane and occasionally over the presynaptic membrane specialization of putative glutamatergic and, to a lesser extent, GABAergic axon terminals. Postsynaptically, the majority of GABAB receptor subunits were localized to the extrasynaptic plasma membrane of spines and dendritic shafts of principal cells and shafts of interneuron dendrites. Quantitative analysis revealed enrichment of GABAB1a/b around putative glutamatergic synapses on spines and an even distribution on dendritic shafts of pyramidal cells contacted by GABAergic boutons. The association of GABAB receptors with glutamatergic synapses at both presynaptic and postsynaptic sides indicates their intimate involvement in the modulation of glutamatergic neurotransmission. The dominant extrasynaptic localization of GABAB receptor subunits suggests that their activation is dependent on spillover of GABA requiring simultaneous activity of populations of GABAergic cells as it occurs during population oscillations or epileptic seizures."}],"extern":1,"day":"03","quality_controlled":0,"status":"public","type":"journal_article","citation":{"mla":"Kulik, Ákos, et al. “Subcellular Localization of Metabotropic GABAB Receptor Subunits GABAB1a/b and GABAB2 in the Rat Hippocampus.” <i>Journal of Neuroscience</i>, vol. 23, no. 35, Society for Neuroscience, 2003, pp. 11026–35.","apa":"Kulik, Á., Vida, I., Luján, R., Haas, C., López Bendito, G., Shigemoto, R., &#38; Frotscher, M. (2003). Subcellular Localization of Metabotropic GABAB Receptor Subunits GABAB1a/b and GABAB2 in the Rat Hippocampus. <i>Journal of Neuroscience</i>. Society for Neuroscience.","ista":"Kulik Á, Vida I, Luján R, Haas C, López Bendito G, Shigemoto R, Frotscher M. 2003. Subcellular Localization of Metabotropic GABAB Receptor Subunits GABAB1a/b and GABAB2 in the Rat Hippocampus. Journal of Neuroscience. 23(35), 11026–11035.","chicago":"Kulik, Ákos, Imre Vida, Rafael Luján, Carola Haas, Guillermina López Bendito, Ryuichi Shigemoto, and Michael Frotscher. “Subcellular Localization of Metabotropic GABAB Receptor Subunits GABAB1a/b and GABAB2 in the Rat Hippocampus.” <i>Journal of Neuroscience</i>. Society for Neuroscience, 2003.","ieee":"Á. Kulik <i>et al.</i>, “Subcellular Localization of Metabotropic GABAB Receptor Subunits GABAB1a/b and GABAB2 in the Rat Hippocampus,” <i>Journal of Neuroscience</i>, vol. 23, no. 35. Society for Neuroscience, pp. 11026–11035, 2003.","short":"Á. Kulik, I. Vida, R. Luján, C. Haas, G. López Bendito, R. Shigemoto, M. Frotscher, Journal of Neuroscience 23 (2003) 11026–11035.","ama":"Kulik Á, Vida I, Luján R, et al. Subcellular Localization of Metabotropic GABAB Receptor Subunits GABAB1a/b and GABAB2 in the Rat Hippocampus. <i>Journal of Neuroscience</i>. 2003;23(35):11026-11035."},"issue":"35","publisher":"Society for Neuroscience","volume":23,"year":"2003","author":[{"first_name":"Ákos","full_name":"Kulik, Ákos","last_name":"Kulik"},{"last_name":"Vida","full_name":"Vida, Imre","first_name":"Imre"},{"last_name":"Luján","full_name":"Luján, Rafael","first_name":"Rafael"},{"first_name":"Carola","full_name":"Haas, Carola A","last_name":"Haas"},{"first_name":"Guillermina","last_name":"López Bendito","full_name":"López-Bendito, Guillermina"},{"full_name":"Ryuichi Shigemoto","orcid":"0000-0001-8761-9444","last_name":"Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi"},{"full_name":"Frotscher, Michael","last_name":"Frotscher","first_name":"Michael"}],"_id":"2635","page":"11026 - 11035","date_updated":"2021-01-12T06:58:43Z","date_created":"2018-12-11T11:58:47Z","publication":"Journal of Neuroscience","title":"Subcellular Localization of Metabotropic GABAB Receptor Subunits GABAB1a/b and GABAB2 in the Rat Hippocampus","month":"12","publication_status":"published","publist_id":"4263"},{"day":"19","extern":1,"abstract":[{"lang":"eng","text":"While the cholinergic depletion in Alzheimer's disease (AD) has been known for some time, a definitive involvement of other neurotransmitter systems has been somewhat more elusive. Our study demonstrates a clear involvement of both glutamatergic and, to a lesser extent, GABAergic neurons in an early onset transgenic mouse model of AD-like amyloid pathology. Immunohistochemical staining and subsequent quantification has revealed a statistically significant increased density of glutamatergic and GABAergic presynaptic boutons in both the plaque free and plaque adjacent cortical neuropile areas of transgenic mice as compared to non-transgenic controls. Furthermore, amyloid plaque size was shown to have a statistically significant effect on the relative area occupied by dystrophic glutamatergic neurites in the peri-plaque neuropile. These findings support our hypothesis that the amyloid pathology progresses in a time and neurotransmitter specific manner, first in the cholinergic system which appears to be most vulnerable, followed by the glutamatergic presynaptic boutons and finally the somewhat more resilient GABAergic terminals."}],"date_published":"2003-12-19T00:00:00Z","intvolume":"       353","year":"2003","volume":353,"citation":{"mla":"Bell, Karen, et al. “Structural Involvement of the Glutamatergic Presynaptic Boutons in a Transgenic Mouse Model Expressing Early Onset Amyloid Pathology.” <i>Neuroscience Letters</i>, vol. 353, no. 2, Elsevier, 2003, pp. 143–47, doi:<a href=\"https://doi.org/10.1016/j.neulet.2003.09.027\">10.1016/j.neulet.2003.09.027</a>.","apa":"Bell, K., De Kort, G. J., Steggerda, S., Shigemoto, R., Ribeiro Da Silva, A., &#38; Cuello, A. (2003). Structural involvement of the glutamatergic presynaptic boutons in a transgenic mouse model expressing early onset amyloid pathology. <i>Neuroscience Letters</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.neulet.2003.09.027\">https://doi.org/10.1016/j.neulet.2003.09.027</a>","short":"K. Bell, G.J. De Kort, S. Steggerda, R. Shigemoto, A. Ribeiro Da Silva, A. Cuello, Neuroscience Letters 353 (2003) 143–147.","ama":"Bell K, De Kort GJ, Steggerda S, Shigemoto R, Ribeiro Da Silva A, Cuello A. Structural involvement of the glutamatergic presynaptic boutons in a transgenic mouse model expressing early onset amyloid pathology. <i>Neuroscience Letters</i>. 2003;353(2):143-147. doi:<a href=\"https://doi.org/10.1016/j.neulet.2003.09.027\">10.1016/j.neulet.2003.09.027</a>","chicago":"Bell, Karen, G J De Kort, S Steggerda, Ryuichi Shigemoto, Alfredo Ribeiro Da Silva, and Augusto Cuello. “Structural Involvement of the Glutamatergic Presynaptic Boutons in a Transgenic Mouse Model Expressing Early Onset Amyloid Pathology.” <i>Neuroscience Letters</i>. Elsevier, 2003. <a href=\"https://doi.org/10.1016/j.neulet.2003.09.027\">https://doi.org/10.1016/j.neulet.2003.09.027</a>.","ieee":"K. Bell, G. J. De Kort, S. Steggerda, R. Shigemoto, A. Ribeiro Da Silva, and A. Cuello, “Structural involvement of the glutamatergic presynaptic boutons in a transgenic mouse model expressing early onset amyloid pathology,” <i>Neuroscience Letters</i>, vol. 353, no. 2. Elsevier, pp. 143–147, 2003.","ista":"Bell K, De Kort GJ, Steggerda S, Shigemoto R, Ribeiro Da Silva A, Cuello A. 2003. Structural involvement of the glutamatergic presynaptic boutons in a transgenic mouse model expressing early onset amyloid pathology. Neuroscience Letters. 353(2), 143–147."},"type":"journal_article","status":"public","issue":"2","publisher":"Elsevier","quality_controlled":0,"title":"Structural involvement of the glutamatergic presynaptic boutons in a transgenic mouse model expressing early onset amyloid pathology","month":"12","date_created":"2018-12-11T11:58:48Z","publication":"Neuroscience Letters","_id":"2637","page":"143 - 147","date_updated":"2021-01-12T06:58:44Z","doi":"10.1016/j.neulet.2003.09.027","author":[{"full_name":"Bell, Karen F","last_name":"Bell","first_name":"Karen"},{"last_name":"De Kort","full_name":"De Kort, G J","first_name":"G J"},{"first_name":"S","full_name":"Steggerda, S","last_name":"Steggerda"},{"last_name":"Shigemoto","orcid":"0000-0001-8761-9444","full_name":"Ryuichi Shigemoto","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Alfredo","last_name":"Ribeiro Da Silva","full_name":"Ribeiro-da-Silva, Alfredo"},{"last_name":"Cuello","full_name":"Cuello, Augusto C","first_name":"Augusto"}],"publist_id":"4262","publication_status":"published"},{"date_published":"2003-05-13T00:00:00Z","intvolume":"       482","extern":1,"day":"13","abstract":[{"lang":"eng","text":"We report the results of an experimental study of magnetohydrodynamic damping of sidewall convection in a rectangular enclosure filled with gallium. In particular we investigate the suppression of convection when a steady magnetic field is applied separately in each of the three principal directions of the flow. The strongest damping of the steady flow is found for a vertical magnetic field, which is in agreement with theory. However, we observe that the application of a field transverse to the flow provides greater damping than a longitudinal one, which seems to contradict available theory. We provide a possible resolution of this apparent dichotomy in terms of the length scale of the experiment."}],"status":"public","citation":{"mla":"Hof, Björn, et al. “Magnetohydrodynamic Damping of Convective Flows in Molten Gallium.” <i>Journal of Fluid Mechanics</i>, vol. 482, Cambridge University Press, 2003, pp. 163–79, doi:<a href=\"https://doi.org/10.1017/S0022112003004014\">10.1017/S0022112003004014</a>.","apa":"Hof, B., Juel, A., &#38; Mullin, T. (2003). Magnetohydrodynamic damping of convective flows in molten gallium. <i>Journal of Fluid Mechanics</i>. Cambridge University Press. <a href=\"https://doi.org/10.1017/S0022112003004014\">https://doi.org/10.1017/S0022112003004014</a>","ista":"Hof B, Juel A, Mullin T. 2003. Magnetohydrodynamic damping of convective flows in molten gallium. Journal of Fluid Mechanics. 482, 163–179.","chicago":"Hof, Björn, Anne Juel, and Tom Mullin. “Magnetohydrodynamic Damping of Convective Flows in Molten Gallium.” <i>Journal of Fluid Mechanics</i>. Cambridge University Press, 2003. <a href=\"https://doi.org/10.1017/S0022112003004014\">https://doi.org/10.1017/S0022112003004014</a>.","ieee":"B. Hof, A. Juel, and T. Mullin, “Magnetohydrodynamic damping of convective flows in molten gallium,” <i>Journal of Fluid Mechanics</i>, vol. 482. Cambridge University Press, pp. 163–179, 2003.","short":"B. Hof, A. Juel, T. Mullin, Journal of Fluid Mechanics 482 (2003) 163–179.","ama":"Hof B, Juel A, Mullin T. Magnetohydrodynamic damping of convective flows in molten gallium. <i>Journal of Fluid Mechanics</i>. 2003;482:163-179. doi:<a href=\"https://doi.org/10.1017/S0022112003004014\">10.1017/S0022112003004014</a>"},"type":"journal_article","publisher":"Cambridge University Press","quality_controlled":0,"year":"2003","volume":482,"_id":"2784","page":"163 - 179","date_updated":"2021-01-12T06:59:42Z","doi":"10.1017/S0022112003004014","author":[{"id":"3A374330-F248-11E8-B48F-1D18A9856A87","first_name":"Björn","full_name":"Björn Hof","last_name":"Hof","orcid":"0000-0003-2057-2754"},{"first_name":"Anne","full_name":"Juel, Anne","last_name":"Juel"},{"first_name":"Tom","full_name":"Mullin, Tom P","last_name":"Mullin"}],"month":"05","title":"Magnetohydrodynamic damping of convective flows in molten gallium","date_created":"2018-12-11T11:59:35Z","publication":"Journal of Fluid Mechanics","publication_status":"published","publist_id":"4105"},{"date_published":"2003-12-12T00:00:00Z","intvolume":"        91","extern":1,"day":"12","abstract":[{"lang":"eng","text":"Experimental evidence for the scaling of the finite amplitude of perturbation theory required to promote transition in Poiseuille flow was found. The exponent is -1 and was uncovered using considerable care in the design and execution of the experiment. Interestingly, this exponent was also found in experiments on transition in boundary layers."}],"status":"public","citation":{"ista":"Hof B, Juel A, Mullin T. 2003. Scaling of the turbulence transition threshold in a pipe. Physical Review Letters. 91(24), 244502/1-244502/4.","ieee":"B. Hof, A. Juel, and T. Mullin, “Scaling of the turbulence transition threshold in a pipe,” <i>Physical Review Letters</i>, vol. 91, no. 24. American Physical Society, p. 244502/1-244502/4, 2003.","chicago":"Hof, Björn, Anne Juel, and Tom Mullin. “Scaling of the Turbulence Transition Threshold in a Pipe.” <i>Physical Review Letters</i>. American Physical Society, 2003. <a href=\"https://doi.org/10.1103/PhysRevLett.91.244502\">https://doi.org/10.1103/PhysRevLett.91.244502</a>.","short":"B. Hof, A. Juel, T. Mullin, Physical Review Letters 91 (2003) 244502/1-244502/4.","ama":"Hof B, Juel A, Mullin T. Scaling of the turbulence transition threshold in a pipe. <i>Physical Review Letters</i>. 2003;91(24):244502/1-244502/4. doi:<a href=\"https://doi.org/10.1103/PhysRevLett.91.244502\">10.1103/PhysRevLett.91.244502</a>","mla":"Hof, Björn, et al. “Scaling of the Turbulence Transition Threshold in a Pipe.” <i>Physical Review Letters</i>, vol. 91, no. 24, American Physical Society, 2003, p. 244502/1-244502/4, doi:<a href=\"https://doi.org/10.1103/PhysRevLett.91.244502\">10.1103/PhysRevLett.91.244502</a>.","apa":"Hof, B., Juel, A., &#38; Mullin, T. (2003). Scaling of the turbulence transition threshold in a pipe. <i>Physical Review Letters</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevLett.91.244502\">https://doi.org/10.1103/PhysRevLett.91.244502</a>"},"type":"journal_article","issue":"24","publisher":"American Physical Society","quality_controlled":0,"year":"2003","volume":91,"_id":"2785","date_updated":"2021-01-12T06:59:42Z","page":"244502/1 - 244502/4","doi":"10.1103/PhysRevLett.91.244502","author":[{"first_name":"Björn","id":"3A374330-F248-11E8-B48F-1D18A9856A87","last_name":"Hof","orcid":"0000-0003-2057-2754","full_name":"Björn Hof"},{"first_name":"Anne","full_name":"Juel, Anne","last_name":"Juel"},{"first_name":"Tom","last_name":"Mullin","full_name":"Mullin, Tom P"}],"title":"Scaling of the turbulence transition threshold in a pipe","month":"12","date_created":"2018-12-11T11:59:35Z","publication":"Physical Review Letters","publication_status":"published","publist_id":"4104"}]