[{"date_updated":"2026-05-08T09:40:06Z","doi":"10.1073/pnas.1432836100","pmid":1,"external_id":{"pmid":["12815098"]},"scopus_import":"1","citation":{"apa":"Hallermann, S., Pawlu, C., Jonas, P. M., &#38; Heckmann, M. (2003). A large pool of releasable vesicles in a cortical glutamatergic synapse. <i>Proceedings of the National Acadamy of Science</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.1432836100\">https://doi.org/10.1073/pnas.1432836100</a>","short":"S. Hallermann, C. Pawlu, P.M. Jonas, M. Heckmann, Proceedings of the National Acadamy of Science 100 (2003) 8975–8980.","mla":"Hallermann, Stefan, et al. “A Large Pool of Releasable Vesicles in a Cortical Glutamatergic Synapse.” <i>Proceedings of the National Acadamy of Science</i>, vol. 100, no. 15, National Academy of Sciences, 2003, pp. 8975–80, doi:<a href=\"https://doi.org/10.1073/pnas.1432836100\">10.1073/pnas.1432836100</a>.","ieee":"S. Hallermann, C. Pawlu, P. M. Jonas, and M. Heckmann, “A large pool of releasable vesicles in a cortical glutamatergic synapse,” <i>Proceedings of the National Acadamy of Science</i>, vol. 100, no. 15. National Academy of Sciences, pp. 8975–8980, 2003.","ista":"Hallermann S, Pawlu C, Jonas PM, Heckmann M. 2003. A large pool of releasable vesicles in a cortical glutamatergic synapse. Proceedings of the National Acadamy of Science. 100(15), 8975–8980.","ama":"Hallermann S, Pawlu C, Jonas PM, Heckmann M. A large pool of releasable vesicles in a cortical glutamatergic synapse. <i>Proceedings of the National Acadamy of Science</i>. 2003;100(15):8975-8980. doi:<a href=\"https://doi.org/10.1073/pnas.1432836100\">10.1073/pnas.1432836100</a>","chicago":"Hallermann, Stefan, Christian Pawlu, Peter M Jonas, and Manfred Heckmann. “A Large Pool of Releasable Vesicles in a Cortical Glutamatergic Synapse.” <i>Proceedings of the National Acadamy of Science</i>. National Academy of Sciences, 2003. <a href=\"https://doi.org/10.1073/pnas.1432836100\">https://doi.org/10.1073/pnas.1432836100</a>."},"year":"2003","volume":100,"publisher":"National Academy of Sciences","title":"A large pool of releasable vesicles in a cortical glutamatergic synapse","page":"8975 - 8980","fulldoi":"https://doi.org/10.1073/pnas.1432836100","author":[{"last_name":"Hallermann","full_name":"Hallermann, Stefan","first_name":"Stefan"},{"last_name":"Pawlu","first_name":"Christian","full_name":"Pawlu, Christian"},{"id":"353C1B58-F248-11E8-B48F-1D18A9856A87","last_name":"Jonas","orcid":"0000-0001-5001-4804","first_name":"Peter M","full_name":"Jonas, Peter M"},{"last_name":"Heckmann","full_name":"Heckmann, Manfred","first_name":"Manfred"}],"publication":"Proceedings of the National Acadamy of Science","issue":"15","publication_identifier":{"issnl":["0027-8424"],"eissn":["1091-6490"]},"extern":"1","oa_version":"None","article_processing_charge":"No","publication_status":"published","abstract":[{"lang":"eng","text":"To probe exocytosis at a cortical glutamatergic synapse, we made capacitance measurements in whole-cell recorded hippocampal mossy fiber terminals. Evaluation of different methods by using a morphology-based equivalent electrical model revealed that quantitative capacitance measurements are possible in this presynaptic structure. Voltage pulses leading to presynaptic Ca2+ inflow evoked large capacitance signals that showed saturation with increasing pulse duration. The mean peak capacitance increase was 100 fF, corresponding to a pool of approximately 1,400 releasable vesicles. Thus hippocampal mossy fiber synapses have a vesicular &quot;maxipool.&quot; Large pool size and rapid vesicle recycling may underlie the uniquely large extent of activity-dependent plasticity in this synapse."}],"status":"public","date_published":"2003-06-18T00:00:00Z","publist_id":"2405","language":[{"iso":"eng"}],"article_type":"original","type":"journal_article","_id":"3806","day":"18","quality_controlled":"1","OA_type":"closed access","month":"06","intvolume":"       100","date_created":"2018-12-11T12:05:16Z","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd"},{"publication_identifier":{"issnl":["0302-9743"],"eisbn":["9783540452201"],"isbn":["9783540408017"]},"title":"Simple stochastic parity games","page":"100 - 113","author":[{"id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","last_name":"Chatterjee","first_name":"Krishnendu","orcid":"0000-0002-4561-241X","full_name":"Chatterjee, Krishnendu"},{"full_name":"Jurdziński, Marcin","first_name":"Marcin","last_name":"Jurdziński"},{"last_name":"Henzinger","id":"40876CD8-F248-11E8-B48F-1D18A9856A87","full_name":"Henzinger, Thomas A","orcid":"0000−0002−2985−7724","first_name":"Thomas A"}],"conference":{"location":"Vienna, Austria","name":"CSL: Computer Science Logic","end_date":"2003-08-30","start_date":"2003-08-25"},"fulldoi":"https://doi.org/10.1007/978-3-540-45220-1_11","volume":2803,"publisher":"Springer nature","citation":{"mla":"Chatterjee, Krishnendu, et al. <i>Simple Stochastic Parity Games</i>. Vol. 2803, Springer nature, 2003, pp. 100–13, doi:<a href=\"https://doi.org/10.1007/978-3-540-45220-1_11\">10.1007/978-3-540-45220-1_11</a>.","apa":"Chatterjee, K., Jurdziński, M., &#38; Henzinger, T. A. (2003). Simple stochastic parity games (Vol. 2803, pp. 100–113). Presented at the CSL: Computer Science Logic, Vienna, Austria: Springer nature. <a href=\"https://doi.org/10.1007/978-3-540-45220-1_11\">https://doi.org/10.1007/978-3-540-45220-1_11</a>","short":"K. Chatterjee, M. Jurdziński, T.A. Henzinger, in:, Springer nature, 2003, pp. 100–113.","chicago":"Chatterjee, Krishnendu, Marcin Jurdziński, and Thomas A Henzinger. “Simple Stochastic Parity Games,” 2803:100–113. Springer nature, 2003. <a href=\"https://doi.org/10.1007/978-3-540-45220-1_11\">https://doi.org/10.1007/978-3-540-45220-1_11</a>.","ama":"Chatterjee K, Jurdziński M, Henzinger TA. Simple stochastic parity games. In: Vol 2803. Springer nature; 2003:100-113. doi:<a href=\"https://doi.org/10.1007/978-3-540-45220-1_11\">10.1007/978-3-540-45220-1_11</a>","ista":"Chatterjee K, Jurdziński M, Henzinger TA. 2003. Simple stochastic parity games. CSL: Computer Science Logic, Lecture Notes in Computer Science, vol. 2803, 100–113.","ieee":"K. Chatterjee, M. Jurdziński, and T. A. Henzinger, “Simple stochastic parity games,” presented at the CSL: Computer Science Logic, Vienna, Austria, 2003, vol. 2803, pp. 100–113."},"year":"2003","doi":"10.1007/978-3-540-45220-1_11","date_updated":"2026-05-06T09:31:49Z","OA_type":"closed access","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","date_created":"2018-12-11T12:05:46Z","month":"08","intvolume":"      2803","quality_controlled":"1","day":"18","_id":"3897","type":"conference","publist_id":"2259","language":[{"iso":"eng"}],"alternative_title":["Lecture Notes in Computer Science"],"oa_version":"None","extern":"1","status":"public","abstract":[{"text":"Many verification, planning, and control problems can be modeled as games played on state-transition graphs by one or two players whose conflicting goals are to form a path in the graph. The focus here is on simple stochastic parity games, that is, two-player games with turn-based probabilistic transitions and omega-regular objectives formalized as parity (Rabin chain) winning conditions. An efficient translation from simple stochastic parity games to nonstochastic parity games is given. As many algorithms are known for solving the latter, the translation yields efficient algorithms for computing the states of a simple stochastic parity game from which a player can win with probability 1. An important special case of simple stochastic parity games are the Markov decision processes with Buchi objectives. For this special case a first provably subquadratic algorithm is given for computing the states from which the single player has a strategy to achieve a Buchi objective with probability 1. For game graphs with m edges the algorithm works in time O(mrootm). Interestingly, a similar technique sheds light on the question of the computational complexity of solving simple Buchi games and yields the first provably subquadratic algorithm, with a running time of O(n(2)/log n) for game graphs with n vertices and O(n) edges.","lang":"eng"}],"publication_status":"published","date_published":"2003-08-18T00:00:00Z","article_processing_charge":"No"},{"page":"109 - 126","title":"Stack size analysis for interrupt-driven programs","conference":{"location":"San Diego, CA, United States","end_date":"2003-06-13","name":"FCRC: Federated Computing Research Conference","start_date":"2003-06-11"},"fulldoi":"https://doi.org/10.1007/3-540-44898-5_7","author":[{"id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","last_name":"Chatterjee","first_name":"Krishnendu","orcid":"0000-0002-4561-241X","full_name":"Chatterjee, Krishnendu"},{"last_name":"Ma","first_name":"Di","full_name":"Ma, Di"},{"last_name":"Majumdar","full_name":"Majumdar, Ritankar","first_name":"Ritankar"},{"full_name":"Zhao, Tian","first_name":"Tian","last_name":"Zhao"},{"last_name":"Henzinger","id":"40876CD8-F248-11E8-B48F-1D18A9856A87","full_name":"Henzinger, Thomas A","first_name":"Thomas A","orcid":"0000−0002−2985−7724"},{"first_name":"Jens","full_name":"Palsberg, Jens","last_name":"Palsberg"}],"publication":"10th International Static Analysis Symposium","publication_identifier":{"isbn":["9783540403258"],"eisbn":["9783540448983"]},"date_updated":"2026-05-06T09:39:35Z","doi":"10.1007/3-540-44898-5_7","year":"2003","citation":{"mla":"Chatterjee, Krishnendu, et al. “Stack Size Analysis for Interrupt-Driven Programs.” <i>10th International Static Analysis Symposium</i>, vol. 2694, Springer nature, 2003, pp. 109–26, doi:<a href=\"https://doi.org/10.1007/3-540-44898-5_7\">10.1007/3-540-44898-5_7</a>.","short":"K. Chatterjee, D. Ma, R. Majumdar, T. Zhao, T.A. Henzinger, J. Palsberg, in:, 10th International Static Analysis Symposium, Springer nature, 2003, pp. 109–126.","apa":"Chatterjee, K., Ma, D., Majumdar, R., Zhao, T., Henzinger, T. A., &#38; Palsberg, J. (2003). Stack size analysis for interrupt-driven programs. In <i>10th International Static Analysis Symposium</i> (Vol. 2694, pp. 109–126). San Diego, CA, United States: Springer nature. <a href=\"https://doi.org/10.1007/3-540-44898-5_7\">https://doi.org/10.1007/3-540-44898-5_7</a>","ieee":"K. Chatterjee, D. Ma, R. Majumdar, T. Zhao, T. A. Henzinger, and J. Palsberg, “Stack size analysis for interrupt-driven programs,” in <i>10th International Static Analysis Symposium</i>, San Diego, CA, United States, 2003, vol. 2694, pp. 109–126.","chicago":"Chatterjee, Krishnendu, Di Ma, Ritankar Majumdar, Tian Zhao, Thomas A Henzinger, and Jens Palsberg. “Stack Size Analysis for Interrupt-Driven Programs.” In <i>10th International Static Analysis Symposium</i>, 2694:109–26. Springer nature, 2003. <a href=\"https://doi.org/10.1007/3-540-44898-5_7\">https://doi.org/10.1007/3-540-44898-5_7</a>.","ama":"Chatterjee K, Ma D, Majumdar R, Zhao T, Henzinger TA, Palsberg J. Stack size analysis for interrupt-driven programs. In: <i>10th International Static Analysis Symposium</i>. Vol 2694. Springer nature; 2003:109-126. doi:<a href=\"https://doi.org/10.1007/3-540-44898-5_7\">10.1007/3-540-44898-5_7</a>","ista":"Chatterjee K, Ma D, Majumdar R, Zhao T, Henzinger TA, Palsberg J. 2003. Stack size analysis for interrupt-driven programs. 10th International Static Analysis Symposium. FCRC: Federated Computing Research Conference, Lecture Notes in Computer Science, vol. 2694, 109–126."},"volume":2694,"publisher":"Springer nature","_id":"3898","day":"13","type":"conference","quality_controlled":"1","OA_type":"closed access","intvolume":"      2694","month":"05","date_created":"2018-12-11T12:05:46Z","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","extern":"1","oa_version":"None","article_processing_charge":"No","date_published":"2003-05-13T00:00:00Z","abstract":[{"lang":"eng","text":"We study the problem of determining stack boundedness and the exact maximum stack size for three classes of interrupt-driven programs. Interrupt-driven programs axe used in many real-time applications that require responsive interrupt handling. In order to ensure responsiveness, programmers often enable interrupt processing in the body of lower-priority interrupt handlers. In such programs a programming error can allow interrupt handlers to be interrupted in cyclic fashion to lead to an unbounded stack, causing the system to crash. For a restricted class of interrupt-driven programs, we show that there is a polynomial-time procedure to check stack boundedness, while determining the exact maximum stack size is PSPACE-complete. For a larger class of programs, the two problems are both PSPACE-complete, and for the largest class of programs we consider, the two problems are PSPACE-hard and can be solved in exponential time."}],"publication_status":"published","status":"public","language":[{"iso":"eng"}],"publist_id":"2260","alternative_title":["Lecture Notes in Computer Science"]},{"month":"01","intvolume":"        12","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2018-12-11T12:05:53Z","OA_type":"closed access","issue":"15","author":[{"full_name":"Cremer, Sylvia","first_name":"Sylvia","orcid":"0000-0002-2193-3868","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","last_name":"Cremer"},{"last_name":"Heinze","full_name":"Heinze, Jürgen","first_name":"Jürgen"}],"publication":"Blick in die Wissenschaft","day":"01","_id":"3917","type":"journal_article","title":"Zwischen Hochzeitsflug und Brudermord: reproduktive Taktiken bei Ameisenmännchen","page":"32 - 36","year":"2003","citation":{"apa":"Cremer, S., &#38; Heinze, J. (2003). Zwischen Hochzeitsflug und Brudermord: reproduktive Taktiken bei Ameisenmännchen. <i>Blick in Die Wissenschaft</i>. Schnell und Steiner.","short":"S. Cremer, J. Heinze, Blick in Die Wissenschaft 12 (2003) 32–36.","mla":"Cremer, Sylvia, and Jürgen Heinze. “Zwischen Hochzeitsflug Und Brudermord: Reproduktive Taktiken Bei Ameisenmännchen.” <i>Blick in Die Wissenschaft</i>, vol. 12, no. 15, Schnell und Steiner, 2003, pp. 32–36.","ista":"Cremer S, Heinze J. 2003. Zwischen Hochzeitsflug und Brudermord: reproduktive Taktiken bei Ameisenmännchen. Blick in die Wissenschaft. 12(15), 32–36.","ama":"Cremer S, Heinze J. Zwischen Hochzeitsflug und Brudermord: reproduktive Taktiken bei Ameisenmännchen. <i>Blick in die Wissenschaft</i>. 2003;12(15):32-36.","chicago":"Cremer, Sylvia, and Jürgen Heinze. “Zwischen Hochzeitsflug Und Brudermord: Reproduktive Taktiken Bei Ameisenmännchen.” <i>Blick in Die Wissenschaft</i>. Schnell und Steiner, 2003.","ieee":"S. Cremer and J. Heinze, “Zwischen Hochzeitsflug und Brudermord: reproduktive Taktiken bei Ameisenmännchen,” <i>Blick in die Wissenschaft</i>, vol. 12, no. 15. Schnell und Steiner, pp. 32–36, 2003."},"publisher":"Schnell und Steiner","volume":12,"publist_id":"2235","language":[{"iso":"eng"}],"article_processing_charge":"No","abstract":[{"text":"Male dimorphism is not genetically determined, but is induced by environmental conditions particularly decreasing temperature and density.","lang":"eng"}],"status":"public","publication_status":"published","date_published":"2003-01-01T00:00:00Z","extern":"1","date_updated":"2026-05-11T10:01:45Z","oa_version":"None"},{"doi":"10.1093/beheco/14.1.54","date_updated":"2026-05-18T09:11:04Z","year":"2003","citation":{"apa":"Anderson, C., Cremer, S., &#38; Heinze, J. (2003). Live and let die: Why fighter males of the ant Cardiocondyla kill each other but tolerate their winged rivals. <i>Behavioral Ecology</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/beheco/14.1.54\">https://doi.org/10.1093/beheco/14.1.54</a>","short":"C. Anderson, S. Cremer, J. Heinze, Behavioral Ecology 14 (2003) 54–62.","mla":"Anderson, Carl, et al. “Live and Let Die: Why Fighter Males of the Ant Cardiocondyla Kill Each Other but Tolerate Their Winged Rivals.” <i>Behavioral Ecology</i>, vol. 14, no. 1, Oxford University Press, 2003, pp. 54–62, doi:<a href=\"https://doi.org/10.1093/beheco/14.1.54\">10.1093/beheco/14.1.54</a>.","ama":"Anderson C, Cremer S, Heinze J. Live and let die: Why fighter males of the ant Cardiocondyla kill each other but tolerate their winged rivals. <i>Behavioral Ecology</i>. 2003;14(1):54-62. doi:<a href=\"https://doi.org/10.1093/beheco/14.1.54\">10.1093/beheco/14.1.54</a>","ista":"Anderson C, Cremer S, Heinze J. 2003. Live and let die: Why fighter males of the ant Cardiocondyla kill each other but tolerate their winged rivals. Behavioral Ecology. 14(1), 54–62.","chicago":"Anderson, Carl, Sylvia Cremer, and Jürgen Heinze. “Live and Let Die: Why Fighter Males of the Ant Cardiocondyla Kill Each Other but Tolerate Their Winged Rivals.” <i>Behavioral Ecology</i>. Oxford University Press, 2003. <a href=\"https://doi.org/10.1093/beheco/14.1.54\">https://doi.org/10.1093/beheco/14.1.54</a>.","ieee":"C. Anderson, S. Cremer, and J. Heinze, “Live and let die: Why fighter males of the ant Cardiocondyla kill each other but tolerate their winged rivals,” <i>Behavioral Ecology</i>, vol. 14, no. 1. Oxford University Press, pp. 54–62, 2003."},"publisher":"Oxford University Press","volume":14,"fulldoi":"https://doi.org/10.1093/beheco/14.1.54","publication":"Behavioral Ecology","author":[{"last_name":"Anderson","first_name":"Carl","full_name":"Anderson, Carl"},{"first_name":"Sylvia","orcid":"0000-0002-2193-3868","full_name":"Cremer, Sylvia","last_name":"Cremer","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Heinze","full_name":"Heinze, Jürgen","first_name":"Jürgen"}],"page":"54 - 62","title":"Live and let die: Why fighter males of the ant Cardiocondyla kill each other but tolerate their winged rivals","issue":"1","article_processing_charge":"No","date_published":"2003-01-01T00:00:00Z","publication_status":"published","status":"public","abstract":[{"lang":"eng","text":"Unlike most social insects, many Cardiocondyla ant species have two male morphs: wingless (ergatoid) males, who remain in the natal nest, and winged males who disperse but, strangely, before leaving may also mate within the nest. Whereas ergatoid males are highly intolerant of each other and fight among themselves, they tend to tolerate their winged counterparts. This is despite the fact that these winged males, like ergatoid males, represent mating competition. Why should ergatoid males tolerate their winged rivals? We developed a mathematical model to address this question. Our model focuses on a number of factors likely toinfluence whether ergatoid males are tolerant of winged males: ergatoid male–winged male relatedness, number of virgin queens, number of winged males, and the number of ejaculates a winged male has (winged males are sperm limited, whereas ergatoid males have lifelong spermatogenesis). Surprisingly, we found that increasing the number of virgin queens favors a kill strategy, whereas an increase in the other factors favors a let-live strategy; these predictions appear true for C. obscurior and for a number of other Cardiocondyla species. Two further aspects, unequal insemination success and multiple mating in queens, were also incorporated into the model and predictions made about their effects on toleration of winged males. The model is applicable more generally in species that have dimorphic males, such as some other ants, bees, and fig wasps."}],"extern":"1","oa_version":"None","language":[{"iso":"eng"}],"article_type":"original","publist_id":"2233","_id":"3921","day":"01","type":"journal_article","quality_controlled":"1","intvolume":"        14","month":"01","date_created":"2018-12-11T12:05:54Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","OA_type":"closed access"},{"issue":"3","fulldoi":"https://doi.org/10.1016/S0960-9822(03)00012-5","author":[{"orcid":"0000-0002-2193-3868","first_name":"Sylvia","full_name":"Cremer, Sylvia","last_name":"Cremer","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Heinze","first_name":"Jürgen","full_name":"Heinze, Jürgen"}],"publication":"Current Biology","page":"219 - 223","title":"Stress grows wings: Environmental induction of winged dispersal males in Cardiocondyla ants","year":"2003","citation":{"mla":"Cremer, Sylvia, and Jürgen Heinze. “Stress Grows Wings: Environmental Induction of Winged Dispersal Males in Cardiocondyla Ants.” <i>Current Biology</i>, vol. 13, no. 3, Elsevier, 2003, pp. 219–23, doi:<a href=\"https://doi.org/10.1016/S0960-9822(03)00012-5\">10.1016/S0960-9822(03)00012-5</a>.","apa":"Cremer, S., &#38; Heinze, J. (2003). Stress grows wings: Environmental induction of winged dispersal males in Cardiocondyla ants. <i>Current Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/S0960-9822(03)00012-5\">https://doi.org/10.1016/S0960-9822(03)00012-5</a>","short":"S. Cremer, J. Heinze, Current Biology 13 (2003) 219–223.","chicago":"Cremer, Sylvia, and Jürgen Heinze. “Stress Grows Wings: Environmental Induction of Winged Dispersal Males in Cardiocondyla Ants.” <i>Current Biology</i>. Elsevier, 2003. <a href=\"https://doi.org/10.1016/S0960-9822(03)00012-5\">https://doi.org/10.1016/S0960-9822(03)00012-5</a>.","ista":"Cremer S, Heinze J. 2003. Stress grows wings: Environmental induction of winged dispersal males in Cardiocondyla ants. Current Biology. 13(3), 219–223.","ama":"Cremer S, Heinze J. Stress grows wings: Environmental induction of winged dispersal males in Cardiocondyla ants. <i>Current Biology</i>. 2003;13(3):219-223. doi:<a href=\"https://doi.org/10.1016/S0960-9822(03)00012-5\">10.1016/S0960-9822(03)00012-5</a>","ieee":"S. Cremer and J. Heinze, “Stress grows wings: Environmental induction of winged dispersal males in Cardiocondyla ants,” <i>Current Biology</i>, vol. 13, no. 3. Elsevier, pp. 219–223, 2003."},"publisher":"Elsevier","volume":13,"OA_place":"publisher","external_id":{"pmid":["12573217"]},"pmid":1,"doi":"10.1016/S0960-9822(03)00012-5","date_updated":"2026-05-18T09:07:29Z","intvolume":"        13","main_file_link":[{"url":"https://doi.org/10.1016/S0960-9822(03)00012-5","open_access":"1"}],"month":"02","date_created":"2018-12-11T12:05:54Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","OA_type":"free access","oa":1,"_id":"3922","type":"journal_article","day":"04","quality_controlled":"1","language":[{"iso":"eng"}],"article_type":"original","publist_id":"2234","article_processing_charge":"No","date_published":"2003-02-04T00:00:00Z","abstract":[{"lang":"eng","text":"Dispersal is advantageous, but, at the same time, it implies high costs and risks. Due to these counteracting selection pressures, many species evolved dispersal polymorphisms, which, in ants, are typically restricted to the female sex (queens). Male polymorphism is presently only known from a few genera, such as Cardiocondyla, in which winged dispersing males coexist with wingless fighter males that mate exclusively inside their maternal nests. We studied the developmental mechanisms underlying these alternative male morphs and found that, first, male dimorphism is not genetically determined, but is induced by environmental conditions (decreasing temperature and density). Second, male morph is not yet fixed at the egg stage, but it differentiates during larval development. This flexible developmental pattern of male morphs allows Cardiocondyla ant colonies to react quickly to changes in their environment. Under good conditions, they invest exclusively in philopatric wingless males. But, when environmental conditions turn bad, colonies start to produce winged dispersal males, even though these males require a many times higher investment by the colony than their much smaller wingless counterparts. Cardiocondyla ants share this potential of optimal resource allocation with other colonial animals and some seed dimorphic plants."}],"status":"public","publication_status":"published","extern":"1","oa_version":"Published Version"},{"volume":2598,"publisher":"Springer","year":"2003","citation":{"chicago":"Cheng, Ho, and Herbert Edelsbrunner. “Area and Perimeter Derivatives of a Union of Disks.” In <i>Computer Science in Perspective: Essays Dedicated to Thomas Ottmann</i>, 2598:88–97. Springer, 2003. <a href=\"https://doi.org/10.1007/3-540-36477-3_7\">https://doi.org/10.1007/3-540-36477-3_7</a>.","ista":"Cheng H, Edelsbrunner H. 2003.Area and perimeter derivatives of a union of disks. In: Computer Science in Perspective: Essays Dedicated to Thomas Ottmann. LNCS, vol. 2598, 88–97.","ama":"Cheng H, Edelsbrunner H. Area and perimeter derivatives of a union of disks. In: <i>Computer Science in Perspective: Essays Dedicated to Thomas Ottmann</i>. Vol 2598. Springer; 2003:88-97. doi:<a href=\"https://doi.org/10.1007/3-540-36477-3_7\">10.1007/3-540-36477-3_7</a>","ieee":"H. Cheng and H. Edelsbrunner, “Area and perimeter derivatives of a union of disks,” in <i>Computer Science in Perspective: Essays Dedicated to Thomas Ottmann</i>, vol. 2598, Springer, 2003, pp. 88–97.","mla":"Cheng, Ho, and Herbert Edelsbrunner. “Area and Perimeter Derivatives of a Union of Disks.” <i>Computer Science in Perspective: Essays Dedicated to Thomas Ottmann</i>, vol. 2598, Springer, 2003, pp. 88–97, doi:<a href=\"https://doi.org/10.1007/3-540-36477-3_7\">10.1007/3-540-36477-3_7</a>.","short":"H. Cheng, H. Edelsbrunner, in:, Computer Science in Perspective: Essays Dedicated to Thomas Ottmann, Springer, 2003, pp. 88–97.","apa":"Cheng, H., &#38; Edelsbrunner, H. (2003). Area and perimeter derivatives of a union of disks. In <i>Computer Science in Perspective: Essays Dedicated to Thomas Ottmann</i> (Vol. 2598, pp. 88–97). Springer. <a href=\"https://doi.org/10.1007/3-540-36477-3_7\">https://doi.org/10.1007/3-540-36477-3_7</a>"},"scopus_import":"1","doi":"10.1007/3-540-36477-3_7","date_updated":"2024-02-27T12:15:02Z","acknowledgement":"Partially supported by NSF under grant DMS-98-73945 and CCR-00-86013.","publication_identifier":{"isbn":["9783540005797"]},"title":"Area and perimeter derivatives of a union of disks","page":"88 - 97","author":[{"first_name":"Ho","full_name":"Cheng, Ho","last_name":"Cheng"},{"first_name":"Herbert","orcid":"0000-0002-9823-6833","full_name":"Edelsbrunner, Herbert","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","last_name":"Edelsbrunner"}],"publication":"Computer Science in Perspective: Essays Dedicated to Thomas Ottmann","fulldoi":"https://doi.org/10.1007/3-540-36477-3_7","publist_id":"2132","language":[{"iso":"eng"}],"alternative_title":["LNCS"],"oa_version":"None","extern":"1","abstract":[{"text":"We give analytic inclusion-exclusion formulas for the area and perimeter derivatives of a union of finitely many disks in the plane.","lang":"eng"}],"publication_status":"published","status":"public","date_published":"2003-02-17T00:00:00Z","article_processing_charge":"No","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_created":"2018-12-11T12:06:18Z","month":"02","intvolume":"      2598","quality_controlled":"1","type":"book_chapter","_id":"3991","day":"17"},{"oa":1,"type":"journal_article","_id":"3992","day":"04","quality_controlled":"1","intvolume":"       100","month":"03","main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC151318/","open_access":"1"}],"date_created":"2018-12-11T12:06:19Z","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No","date_published":"2003-03-04T00:00:00Z","abstract":[{"text":"Computing the volume occupied by individual atoms in macromolecular structures has been the subject of research for several decades. This interest has grown in the recent years, because weighted volumes are widely used in implicit solvent models. Applications of the latter in molecular mechanics simulations require that the derivatives of these weighted volumes be known. In this article, we give a formula for the volume derivative of a molecule modeled as a space-filling diagram made up of balls in motion. The formula is given in terms of the weights, radii, and distances between the centers as well as the sizes of the facets of the power diagram restricted to the space-filling diagram. Special attention is given to the detection and treatment of singularities as well as discontinuities of the derivative.","lang":"eng"}],"status":"public","publication_status":"published","extern":"1","oa_version":"Published Version","language":[{"iso":"eng"}],"article_type":"original","publist_id":"2133","fulldoi":"https://doi.org/10.1073/pnas.0537830100","publication":"PNAS","author":[{"last_name":"Edelsbrunner","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","first_name":"Herbert","orcid":"0000-0002-9823-6833","full_name":"Edelsbrunner, Herbert"},{"last_name":"Koehl","full_name":"Koehl, Patrice","first_name":"Patrice"}],"page":"2203 - 2208","title":"The weighted-volume derivative of a space-filling diagram","publication_identifier":{"issn":["0027-8424"]},"issue":"5","external_id":{"pmid":["12601153"]},"pmid":1,"date_updated":"2024-02-27T12:31:59Z","doi":"10.1073/pnas.0537830100","scopus_import":"1","citation":{"short":"H. Edelsbrunner, P. Koehl, PNAS 100 (2003) 2203–2208.","apa":"Edelsbrunner, H., &#38; Koehl, P. (2003). The weighted-volume derivative of a space-filling diagram. <i>PNAS</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.0537830100\">https://doi.org/10.1073/pnas.0537830100</a>","mla":"Edelsbrunner, Herbert, and Patrice Koehl. “The Weighted-Volume Derivative of a Space-Filling Diagram.” <i>PNAS</i>, vol. 100, no. 5, National Academy of Sciences, 2003, pp. 2203–08, doi:<a href=\"https://doi.org/10.1073/pnas.0537830100\">10.1073/pnas.0537830100</a>.","ista":"Edelsbrunner H, Koehl P. 2003. The weighted-volume derivative of a space-filling diagram. PNAS. 100(5), 2203–2208.","ama":"Edelsbrunner H, Koehl P. The weighted-volume derivative of a space-filling diagram. <i>PNAS</i>. 2003;100(5):2203-2208. doi:<a href=\"https://doi.org/10.1073/pnas.0537830100\">10.1073/pnas.0537830100</a>","chicago":"Edelsbrunner, Herbert, and Patrice Koehl. “The Weighted-Volume Derivative of a Space-Filling Diagram.” <i>PNAS</i>. National Academy of Sciences, 2003. <a href=\"https://doi.org/10.1073/pnas.0537830100\">https://doi.org/10.1073/pnas.0537830100</a>.","ieee":"H. Edelsbrunner and P. Koehl, “The weighted-volume derivative of a space-filling diagram,” <i>PNAS</i>, vol. 100, no. 5. National Academy of Sciences, pp. 2203–2208, 2003."},"year":"2003","publisher":"National Academy of Sciences","volume":100},{"extern":"1","oa_version":"None","article_processing_charge":"No","date_published":"2003-05-01T00:00:00Z","publication_status":"published","abstract":[{"text":"We present algorithms for constructing a hierarchy of increasingly coarse Morse-Smale complexes that decompose a piecewise linear 2-manifold. While these complexes are defined only in the smooth category, we extend the construction to the piecewise linearcategory by ensuring structural integrity and simulating differentiability. We then simplify Morse-Smale complexes by canceling pairs of critical points in order of increasing persistence.","lang":"eng"}],"status":"public","language":[{"iso":"eng"}],"article_type":"original","publist_id":"2134","day":"01","_id":"3993","type":"journal_article","quality_controlled":"1","OA_type":"closed access","intvolume":"        30","month":"05","date_created":"2018-12-11T12:06:19Z","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","date_updated":"2026-05-06T08:08:23Z","doi":"10.1007/s00454-003-2926-5","citation":{"ieee":"H. Edelsbrunner, J. Harer, and A. Zomorodian, “Hierarchical Morse-Smale complexes for piecewise linear 2-manifolds,” <i>Discrete &#38; Computational Geometry</i>, vol. 30. Springer nature, pp. 87–107, 2003.","ama":"Edelsbrunner H, Harer J, Zomorodian A. Hierarchical Morse-Smale complexes for piecewise linear 2-manifolds. <i>Discrete &#38; Computational Geometry</i>. 2003;30:87-107. doi:<a href=\"https://doi.org/10.1007/s00454-003-2926-5\">10.1007/s00454-003-2926-5</a>","ista":"Edelsbrunner H, Harer J, Zomorodian A. 2003. Hierarchical Morse-Smale complexes for piecewise linear 2-manifolds. Discrete &#38; Computational Geometry. 30, 87–107.","chicago":"Edelsbrunner, Herbert, John Harer, and Afra Zomorodian. “Hierarchical Morse-Smale Complexes for Piecewise Linear 2-Manifolds.” <i>Discrete &#38; Computational Geometry</i>. Springer nature, 2003. <a href=\"https://doi.org/10.1007/s00454-003-2926-5\">https://doi.org/10.1007/s00454-003-2926-5</a>.","apa":"Edelsbrunner, H., Harer, J., &#38; Zomorodian, A. (2003). Hierarchical Morse-Smale complexes for piecewise linear 2-manifolds. <i>Discrete &#38; Computational Geometry</i>. Springer nature. <a href=\"https://doi.org/10.1007/s00454-003-2926-5\">https://doi.org/10.1007/s00454-003-2926-5</a>","short":"H. Edelsbrunner, J. Harer, A. Zomorodian, Discrete &#38; Computational Geometry 30 (2003) 87–107.","mla":"Edelsbrunner, Herbert, et al. “Hierarchical Morse-Smale Complexes for Piecewise Linear 2-Manifolds.” <i>Discrete &#38; Computational Geometry</i>, vol. 30, Springer nature, 2003, pp. 87–107, doi:<a href=\"https://doi.org/10.1007/s00454-003-2926-5\">10.1007/s00454-003-2926-5</a>."},"year":"2003","publisher":"Springer nature","volume":30,"page":"87 - 107","title":"Hierarchical Morse-Smale complexes for piecewise linear 2-manifolds","fulldoi":"https://doi.org/10.1007/s00454-003-2926-5","author":[{"full_name":"Edelsbrunner, Herbert","orcid":"0000-0002-9823-6833","first_name":"Herbert","last_name":"Edelsbrunner","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Harer","first_name":"John","full_name":"Harer, John"},{"full_name":"Zomorodian, Afra","first_name":"Afra","last_name":"Zomorodian"}],"publication":"Discrete & Computational Geometry","publication_identifier":{"eissn":["1432-0444"],"issnl":["0179-5376"]}},{"OA_type":"closed access","keyword":["Computational geometry","Differential geometry","Skin curves","Voronoi diagrams","Delaunay triangulations","Filtrations","Disks","Hyperbolas","Area","Perimeter","Derivatives"],"date_created":"2018-12-11T12:06:20Z","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","intvolume":"        26","month":"10","quality_controlled":"1","_id":"3994","type":"journal_article","day":"01","article_type":"original","language":[{"iso":"eng"}],"publist_id":"2135","oa_version":"None","extern":"1","date_published":"2003-10-01T00:00:00Z","abstract":[{"text":"The body defined by a finite collection of disks is a subset of the plane bounded by a tangent continuous curve, which we call the skin. We give analytic formulas for the area, the perimeter, the area derivative, and the perimeter derivative of the body. Given the filtrations of the Delaunay triangulation and the Voronoi diagram of the disks, all formulas can be evaluated in time proportional to the number of disks.","lang":"eng"}],"status":"public","publication_status":"published","article_processing_charge":"No","issue":"2","page":"173 - 192","title":"Area, perimeter and derivatives of a skin curve","publication":"Computational Geometry","author":[{"full_name":"Cheng, Ho","first_name":"Ho","last_name":"Cheng"},{"id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","last_name":"Edelsbrunner","first_name":"Herbert","orcid":"0000-0002-9823-6833","full_name":"Edelsbrunner, Herbert"}],"fulldoi":"https://doi.org/10.1016/S0925-7721(02)00124-4","publisher":"Elsevier","volume":26,"citation":{"ieee":"H. Cheng and H. Edelsbrunner, “Area, perimeter and derivatives of a skin curve,” <i>Computational Geometry</i>, vol. 26, no. 2. Elsevier, pp. 173–192, 2003.","chicago":"Cheng, Ho, and Herbert Edelsbrunner. “Area, Perimeter and Derivatives of a Skin Curve.” <i>Computational Geometry</i>. Elsevier, 2003. <a href=\"https://doi.org/10.1016/S0925-7721(02)00124-4\">https://doi.org/10.1016/S0925-7721(02)00124-4</a>.","ama":"Cheng H, Edelsbrunner H. Area, perimeter and derivatives of a skin curve. <i>Computational Geometry</i>. 2003;26(2):173-192. doi:<a href=\"https://doi.org/10.1016/S0925-7721(02)00124-4\">10.1016/S0925-7721(02)00124-4</a>","ista":"Cheng H, Edelsbrunner H. 2003. Area, perimeter and derivatives of a skin curve. Computational Geometry. 26(2), 173–192.","mla":"Cheng, Ho, and Herbert Edelsbrunner. “Area, Perimeter and Derivatives of a Skin Curve.” <i>Computational Geometry</i>, vol. 26, no. 2, Elsevier, 2003, pp. 173–92, doi:<a href=\"https://doi.org/10.1016/S0925-7721(02)00124-4\">10.1016/S0925-7721(02)00124-4</a>.","apa":"Cheng, H., &#38; Edelsbrunner, H. (2003). Area, perimeter and derivatives of a skin curve. <i>Computational Geometry</i>. Elsevier. <a href=\"https://doi.org/10.1016/S0925-7721(02)00124-4\">https://doi.org/10.1016/S0925-7721(02)00124-4</a>","short":"H. Cheng, H. Edelsbrunner, Computational Geometry 26 (2003) 173–192."},"year":"2003","doi":"10.1016/S0925-7721(02)00124-4","date_updated":"2026-05-06T08:12:09Z"},{"type":"conference","_id":"3997","day":"01","quality_controlled":"1","page":"139 - 146","title":"A multi-resolution data structure for two-dimensional Morse-Smale functions","conference":{"start_date":"2003-10-19","end_date":"2003-10-24","name":"VIS: IEEE Visualization","location":"Seattle, WA, USA "},"fulldoi":"https://doi.org/10.1109/VISUAL.2003.1250365","publication":"Proceedings of the 14th IEEE Conference on Visualization ","author":[{"first_name":"Peer","full_name":"Bremer, Peer","last_name":"Bremer"},{"id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","last_name":"Edelsbrunner","full_name":"Edelsbrunner, Herbert","first_name":"Herbert","orcid":"0000-0002-9823-6833"},{"last_name":"Hamann","first_name":"Bernd","full_name":"Hamann, Bernd"},{"last_name":"Pascucci","first_name":"Valerio","full_name":"Pascucci, Valerio"}],"acknowledgement":"This work was performed under the auspices of the U. S. Department of Energy by University of California Lawrence Livermore National Laboratory under contract No. W-7405-Eng-48. H. Edelsbrunner is partially supported by the National Science Foundation (NFS) under grants EIA-99-72879 and CCR-00-86013. B. Hamann is supported by the NSF under contract ACI 9624034, through the LSSDSV program under contract ACI 9982251, and through the NPACI; the National Institute of Mental Health and the NSF under contract NIMH 2 P20 MH60975-06A2; the Lawrence Livermore National Laboratory under ASCI ASAP Level-2 Memorandum Agreement B347878 and under Memorandum Agreement B503159.","month":"08","publication_identifier":{"isbn":["0780381203"]},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_created":"2018-12-11T12:06:21Z","doi":"10.1109/VISUAL.2003.1250365","extern":"1","date_updated":"2024-02-27T11:12:50Z","oa_version":"None","scopus_import":"1","article_processing_charge":"No","date_published":"2003-08-01T00:00:00Z","publication_status":"published","abstract":[{"lang":"eng","text":"We combine topological and geometric methods to construct a multi-resolution data structure for functions over two-dimensional domains. Starting with the Morse-Smale complex, we construct a topological hierarchy by progressively canceling critical points in pairs. Concurrently, we create a geometric hierarchy by adapting the geometry to the changes in topology. The data structure supports mesh traversal operations similarly to traditional multi-resolution representations."}],"status":"public","language":[{"iso":"eng"}],"publist_id":"2131","year":"2003","citation":{"ieee":"P. Bremer, H. Edelsbrunner, B. Hamann, and V. Pascucci, “A multi-resolution data structure for two-dimensional Morse-Smale functions,” in <i>Proceedings of the 14th IEEE Conference on Visualization </i>, Seattle, WA, USA , 2003, pp. 139–146.","chicago":"Bremer, Peer, Herbert Edelsbrunner, Bernd Hamann, and Valerio Pascucci. “A Multi-Resolution Data Structure for Two-Dimensional Morse-Smale Functions.” In <i>Proceedings of the 14th IEEE Conference on Visualization </i>, 139–46. IEEE, 2003. <a href=\"https://doi.org/10.1109/VISUAL.2003.1250365\">https://doi.org/10.1109/VISUAL.2003.1250365</a>.","ama":"Bremer P, Edelsbrunner H, Hamann B, Pascucci V. A multi-resolution data structure for two-dimensional Morse-Smale functions. In: <i>Proceedings of the 14th IEEE Conference on Visualization </i>. IEEE; 2003:139-146. doi:<a href=\"https://doi.org/10.1109/VISUAL.2003.1250365\">10.1109/VISUAL.2003.1250365</a>","ista":"Bremer P, Edelsbrunner H, Hamann B, Pascucci V. 2003. A multi-resolution data structure for two-dimensional Morse-Smale functions. Proceedings of the 14th IEEE Conference on Visualization . VIS: IEEE Visualization, 139–146.","mla":"Bremer, Peer, et al. “A Multi-Resolution Data Structure for Two-Dimensional Morse-Smale Functions.” <i>Proceedings of the 14th IEEE Conference on Visualization </i>, IEEE, 2003, pp. 139–46, doi:<a href=\"https://doi.org/10.1109/VISUAL.2003.1250365\">10.1109/VISUAL.2003.1250365</a>.","apa":"Bremer, P., Edelsbrunner, H., Hamann, B., &#38; Pascucci, V. (2003). A multi-resolution data structure for two-dimensional Morse-Smale functions. In <i>Proceedings of the 14th IEEE Conference on Visualization </i> (pp. 139–146). Seattle, WA, USA : IEEE. <a href=\"https://doi.org/10.1109/VISUAL.2003.1250365\">https://doi.org/10.1109/VISUAL.2003.1250365</a>","short":"P. Bremer, H. Edelsbrunner, B. Hamann, V. Pascucci, in:, Proceedings of the 14th IEEE Conference on Visualization , IEEE, 2003, pp. 139–146."},"publisher":"IEEE"},{"quality_controlled":"1","_id":"3999","type":"conference","day":"16","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_created":"2018-12-11T12:06:21Z","intvolume":"      2866","month":"12","date_published":"2003-12-16T00:00:00Z","abstract":[{"text":"We introduce relaxed scheduling as a paradigm for mesh maintenance and demonstrate its applicability to triangulating a skin surface in R-3.","lang":"eng"}],"publication_status":"published","status":"public","article_processing_charge":"No","oa_version":"None","extern":"1","alternative_title":["LNCS"],"language":[{"iso":"eng"}],"publist_id":"2127","publication":"Proceedings of the Japanese Conference on Discrete and Computational Geometry ","author":[{"last_name":"Edelsbrunner","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-9823-6833","first_name":"Herbert","full_name":"Edelsbrunner, Herbert"},{"last_name":"Üngör","full_name":"Üngör, Alper","first_name":"Alper"}],"fulldoi":"https://doi.org/10.1007/978-3-540-44400-8_14","conference":{"end_date":"2002-12-09","name":"JCDCG: Japanese Conference on Discrete and Computational Geometry","start_date":"2002-12-06","location":"Tokyo, Japan"},"page":"135 - 151","title":"Relaxed scheduling in dynamic skin triangulation","publication_identifier":{"isbn":["9783540207764"]},"acknowledgement":"NSF under grant CCR-00- 86013.","scopus_import":"1","date_updated":"2024-02-27T11:07:15Z","doi":"10.1007/978-3-540-44400-8_14","publisher":"Springer","volume":2866,"citation":{"ista":"Edelsbrunner H, Üngör A. 2003. Relaxed scheduling in dynamic skin triangulation. Proceedings of the Japanese Conference on Discrete and Computational Geometry . JCDCG: Japanese Conference on Discrete and Computational Geometry, LNCS, vol. 2866, 135–151.","ama":"Edelsbrunner H, Üngör A. Relaxed scheduling in dynamic skin triangulation. In: <i>Proceedings of the Japanese Conference on Discrete and Computational Geometry </i>. Vol 2866. Springer; 2003:135-151. doi:<a href=\"https://doi.org/10.1007/978-3-540-44400-8_14\">10.1007/978-3-540-44400-8_14</a>","chicago":"Edelsbrunner, Herbert, and Alper Üngör. “Relaxed Scheduling in Dynamic Skin Triangulation.” In <i>Proceedings of the Japanese Conference on Discrete and Computational Geometry </i>, 2866:135–51. Springer, 2003. <a href=\"https://doi.org/10.1007/978-3-540-44400-8_14\">https://doi.org/10.1007/978-3-540-44400-8_14</a>.","ieee":"H. Edelsbrunner and A. Üngör, “Relaxed scheduling in dynamic skin triangulation,” in <i>Proceedings of the Japanese Conference on Discrete and Computational Geometry </i>, Tokyo, Japan, 2003, vol. 2866, pp. 135–151.","short":"H. Edelsbrunner, A. Üngör, in:, Proceedings of the Japanese Conference on Discrete and Computational Geometry , Springer, 2003, pp. 135–151.","apa":"Edelsbrunner, H., &#38; Üngör, A. (2003). Relaxed scheduling in dynamic skin triangulation. In <i>Proceedings of the Japanese Conference on Discrete and Computational Geometry </i> (Vol. 2866, pp. 135–151). Tokyo, Japan: Springer. <a href=\"https://doi.org/10.1007/978-3-540-44400-8_14\">https://doi.org/10.1007/978-3-540-44400-8_14</a>","mla":"Edelsbrunner, Herbert, and Alper Üngör. “Relaxed Scheduling in Dynamic Skin Triangulation.” <i>Proceedings of the Japanese Conference on Discrete and Computational Geometry </i>, vol. 2866, Springer, 2003, pp. 135–51, doi:<a href=\"https://doi.org/10.1007/978-3-540-44400-8_14\">10.1007/978-3-540-44400-8_14</a>."},"year":"2003"},{"year":"2003","citation":{"apa":"Ulrich, F., Concha, M., Heid, P., Voss, E., Witzel, S., Roehl, H., … Heisenberg, C.-P. J. (2003). Slb/Wnt11 controls hypoblast cell migration and morphogenesis at the onset of zebrafish gastrulation. <i>Development</i>. Company of Biologists. <a href=\"https://doi.org/10.1242/dev.00758\">https://doi.org/10.1242/dev.00758</a>","short":"F. Ulrich, M. Concha, P. Heid, E. Voss, S. Witzel, H. Roehl, M. Tada, S. Wilson, R. Adams, D. Soll, C.-P.J. Heisenberg, Development 130 (2003) 5375–5384.","mla":"Ulrich, Florian, et al. “Slb/Wnt11 Controls Hypoblast Cell Migration and Morphogenesis at the Onset of Zebrafish Gastrulation.” <i>Development</i>, vol. 130, no. 22, Company of Biologists, 2003, pp. 5375–84, doi:<a href=\"https://doi.org/10.1242/dev.00758\">10.1242/dev.00758</a>.","ista":"Ulrich F, Concha M, Heid P, Voss E, Witzel S, Roehl H, Tada M, Wilson S, Adams R, Soll D, Heisenberg C-PJ. 2003. Slb/Wnt11 controls hypoblast cell migration and morphogenesis at the onset of zebrafish gastrulation. Development. 130(22), 5375–5384.","ama":"Ulrich F, Concha M, Heid P, et al. Slb/Wnt11 controls hypoblast cell migration and morphogenesis at the onset of zebrafish gastrulation. <i>Development</i>. 2003;130(22):5375-5384. doi:<a href=\"https://doi.org/10.1242/dev.00758\">10.1242/dev.00758</a>","chicago":"Ulrich, Florian, Miguel Concha, Paul Heid, Ed Voss, Sabine Witzel, Henry Roehl, Masazumi Tada, et al. “Slb/Wnt11 Controls Hypoblast Cell Migration and Morphogenesis at the Onset of Zebrafish Gastrulation.” <i>Development</i>. Company of Biologists, 2003. <a href=\"https://doi.org/10.1242/dev.00758\">https://doi.org/10.1242/dev.00758</a>.","ieee":"F. Ulrich <i>et al.</i>, “Slb/Wnt11 controls hypoblast cell migration and morphogenesis at the onset of zebrafish gastrulation,” <i>Development</i>, vol. 130, no. 22. Company of Biologists, pp. 5375–5384, 2003."},"volume":130,"publisher":"Company of Biologists","external_id":{"pmid":[" PMC1414802"]},"pmid":1,"doi":"10.1242/dev.00758","date_updated":"2024-02-27T10:14:21Z","scopus_import":"1","publication_identifier":{"issn":["1011-6370"]},"issue":"22","acknowledgement":"We thank Jennifer Geiger, Mathias Köppen, Christian Dahmann and Marcos Gonzalez-Gaitan for helpful comments on earlier versions of this manuscript,Beate Kilian for technical assistance, Ugur Yalcin, Katrin Anczok and Viktor Schnabel for help with the image analysis, Vinzenz Link for programming Excel Macros and Harald Brush-Janovjak for extensive reviews of the statistics part of this work. We are grateful to Kurt Anderson and Jan Peychl for help with the confocal microscopy. P.J.H., E.V. and D.R.S. are supported by NIH grant HD-18577, The W.M Keck Foundation and the Developmental Studies Hybridoma Bank(DSHB), P.J.H. by The American Cancer Society (grant # PF-01-110-01-CSM),M.L.C. and S.W.W. by the Wellcome Trust, M.T. by an MRC Career Development Award, and F.U. and C.P.H. by an Emmy-Noether-Fellowship from the DFG.","fulldoi":"https://doi.org/10.1242/dev.00758","author":[{"last_name":"Ulrich","full_name":"Ulrich, Florian","first_name":"Florian"},{"full_name":"Concha, Miguel","first_name":"Miguel","last_name":"Concha"},{"full_name":"Heid, Paul","first_name":"Paul","last_name":"Heid"},{"last_name":"Voss","first_name":"Ed","full_name":"Voss, Ed"},{"last_name":"Witzel","full_name":"Witzel, Sabine","first_name":"Sabine"},{"last_name":"Roehl","first_name":"Henry","full_name":"Roehl, Henry"},{"first_name":"Masazumi","full_name":"Tada, Masazumi","last_name":"Tada"},{"full_name":"Wilson, Stephen","first_name":"Stephen","last_name":"Wilson"},{"full_name":"Adams, Richard","first_name":"Richard","last_name":"Adams"},{"last_name":"Soll","first_name":"David","full_name":"Soll, David"},{"id":"39427864-F248-11E8-B48F-1D18A9856A87","last_name":"Heisenberg","full_name":"Heisenberg, Carl-Philipp J","orcid":"0000-0002-0912-4566","first_name":"Carl-Philipp J"}],"publication":"Development","page":"5375 - 5384","title":"Slb/Wnt11 controls hypoblast cell migration and morphogenesis at the onset of zebrafish gastrulation","language":[{"iso":"eng"}],"article_type":"original","publist_id":"1975","article_processing_charge":"No","date_published":"2003-11-15T00:00:00Z","publication_status":"published","abstract":[{"lang":"eng","text":"During vertebrate gastrulation, highly coordinated cellular rearrangements lead to the formation of the three germ layers, ectoderm, mesoderm and endoderm. In zebrafish, silberblick (slb)/wnt11 regulates normal gastrulation movements by activating a signalling pathway similar to the Frizzled-signalling pathway, which establishes epithelial planar cell polarity (PCP) in Drosophila. However, the cellular mechanisms by which slb/wnt11 functions during zebrafish gastrulation are still unclear. Using high-resolution two-photon confocal imaging followed by computer-assisted reconstruction and motion analysis, we have analysed the movement and morphology of individual cells in three dimensions during the course of gastrulation. We show that in slb-mutant embryos, hypoblast cells within the forming germ ring have slower, less directed migratory movements at the onset of gastrulation. These aberrant cell movements are accompanied by defects in the orientation of cellular processes along the individual movement directions of these cells. We conclude that slb/wnt11-mediated orientation of cellular processes plays a role in facilitating and stabilising movements of hypoblast cells in the germ ring, thereby pointing at a novel function of the slb/wnt11 signalling pathway for the regulation of migratory cell movements at early stages of gastrulation."}],"status":"public","extern":"1","oa_version":"None","intvolume":"       130","main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1414802/","open_access":"1"}],"month":"11","date_created":"2018-12-11T12:07:13Z","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","oa":1,"type":"journal_article","_id":"4146","day":"15","quality_controlled":"1"},{"date_published":"2003-08-01T00:00:00Z","publication_status":"published","status":"public","abstract":[{"lang":"eng","text":"Recent studies show that signaling through integrin receptors is required for normal cell movements during Xenopus gastrulation. Integrins function in this process by modulating the activity of cadherin adhesion molecules within tissues undergoing convergence and extension movements."}],"article_processing_charge":"No","oa_version":"None","extern":"1","language":[{"iso":"eng"}],"article_type":"original","publist_id":"1949","quality_controlled":"1","day":"01","_id":"4168","type":"journal_article","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_created":"2018-12-11T12:07:21Z","intvolume":"         5","month":"08","scopus_import":"1","external_id":{"pmid":["12919669 "]},"pmid":1,"date_updated":"2024-02-27T09:54:53Z","doi":"10.1016/S1534-5807(03)00235-1","volume":5,"publisher":"Cell Press","citation":{"ieee":"J. Montero and C.-P. J. Heisenberg, “Adhesive crosstalk in gastrulation,” <i>Developmental Cell</i>, vol. 5, no. 2. Cell Press, pp. 190–191, 2003.","ista":"Montero J, Heisenberg C-PJ. 2003. Adhesive crosstalk in gastrulation. Developmental Cell. 5(2), 190–191.","ama":"Montero J, Heisenberg C-PJ. Adhesive crosstalk in gastrulation. <i>Developmental Cell</i>. 2003;5(2):190-191. doi:<a href=\"https://doi.org/10.1016/S1534-5807(03)00235-1\">10.1016/S1534-5807(03)00235-1</a>","chicago":"Montero, Juan, and Carl-Philipp J Heisenberg. “Adhesive Crosstalk in Gastrulation.” <i>Developmental Cell</i>. Cell Press, 2003. <a href=\"https://doi.org/10.1016/S1534-5807(03)00235-1\">https://doi.org/10.1016/S1534-5807(03)00235-1</a>.","short":"J. Montero, C.-P.J. Heisenberg, Developmental Cell 5 (2003) 190–191.","apa":"Montero, J., &#38; Heisenberg, C.-P. J. (2003). Adhesive crosstalk in gastrulation. <i>Developmental Cell</i>. Cell Press. <a href=\"https://doi.org/10.1016/S1534-5807(03)00235-1\">https://doi.org/10.1016/S1534-5807(03)00235-1</a>","mla":"Montero, Juan, and Carl-Philipp J. Heisenberg. “Adhesive Crosstalk in Gastrulation.” <i>Developmental Cell</i>, vol. 5, no. 2, Cell Press, 2003, pp. 190–91, doi:<a href=\"https://doi.org/10.1016/S1534-5807(03)00235-1\">10.1016/S1534-5807(03)00235-1</a>."},"year":"2003","publication":"Developmental Cell","author":[{"first_name":"Juan","full_name":"Montero, Juan","last_name":"Montero"},{"full_name":"Heisenberg, Carl-Philipp J","orcid":"0000-0002-0912-4566","first_name":"Carl-Philipp J","last_name":"Heisenberg","id":"39427864-F248-11E8-B48F-1D18A9856A87"}],"fulldoi":"https://doi.org/10.1016/S1534-5807(03)00235-1","page":"190 - 191","title":"Adhesive crosstalk in gastrulation","publication_identifier":{"issn":["1534-5807"],"eissn":["1878-1551"]},"issue":"2"},{"oa_version":"None","extern":"1","date_published":"2003-08-05T00:00:00Z","status":"public","publication_status":"published","abstract":[{"lang":"eng","text":"Background: During vertebrate gastrulation, cell polarization and migration are core components in the cellular rearrangements that lead to the formation of the three germ layers, ectoderm, mesoderm, and endoderm. Previous studies have implicated the Wnt/planar cell polarity (PCP) signaling pathway in controlling cell morphology and movement during gastrulation. However, cell polarization and directed cell migration are reduced but not completely abolished in the absence of Wnt/PCP signals; this observation indicates that other signaling pathways must be involved. Results: We show that Phosphoinositide 3-Kinases (PI3Ks) are required at the onset of zebrafish gastrulation in mesendodermal cells for process formation and cell polarization. Platelet Derived Growth Factor (PDGF) functions upstream of PI3K, while Protein Kinase B (PKB), a downstream effector of PI3K activity, localizes to the leading edge of migrating mesendodermal cells. In the absence of PI3K activity, PKB localization and cell polarization are strongly reduced in mesendodermal cells and are followed by slower but still highly coordinated and directed movements of these cells. Conclusions: We have identified a novel role of a signaling pathway comprised of PDGF, PI3K, and PKB in the control of morphogenetic cell movements during gastrulation. Furthermore, our findings provide insight into the relationship between cell polarization and directed cell migration at the onset of zebrafish gastrulation."}],"article_processing_charge":"No","language":[{"iso":"eng"}],"article_type":"original","publist_id":"1950","quality_controlled":"1","day":"05","_id":"4169","type":"journal_article","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_created":"2018-12-11T12:07:22Z","intvolume":"        13","month":"08","scopus_import":"1","pmid":1,"external_id":{"pmid":[" 12906787"]},"doi":"10.1016/S0960-9822(03)00505-0","date_updated":"2024-02-27T10:03:37Z","volume":13,"publisher":"Cell Press","year":"2003","citation":{"apa":"Montero, J., Kilian, B., Chan, J., Bayliss, P., &#38; Heisenberg, C.-P. J. (2003). Phosphoinositide 3-kinase is required for process outgrowth and cell polarization of gastrulating mesendodermal cells. <i>Current Biology</i>. Cell Press. <a href=\"https://doi.org/10.1016/S0960-9822(03)00505-0\">https://doi.org/10.1016/S0960-9822(03)00505-0</a>","short":"J. Montero, B. Kilian, J. Chan, P. Bayliss, C.-P.J. Heisenberg, Current Biology 13 (2003) 1279–1289.","mla":"Montero, Juan, et al. “Phosphoinositide 3-Kinase Is Required for Process Outgrowth and Cell Polarization of Gastrulating Mesendodermal Cells.” <i>Current Biology</i>, vol. 13, no. 15, Cell Press, 2003, pp. 1279–89, doi:<a href=\"https://doi.org/10.1016/S0960-9822(03)00505-0\">10.1016/S0960-9822(03)00505-0</a>.","ieee":"J. Montero, B. Kilian, J. Chan, P. Bayliss, and C.-P. J. Heisenberg, “Phosphoinositide 3-kinase is required for process outgrowth and cell polarization of gastrulating mesendodermal cells,” <i>Current Biology</i>, vol. 13, no. 15. Cell Press, pp. 1279–1289, 2003.","ista":"Montero J, Kilian B, Chan J, Bayliss P, Heisenberg C-PJ. 2003. Phosphoinositide 3-kinase is required for process outgrowth and cell polarization of gastrulating mesendodermal cells. Current Biology. 13(15), 1279–1289.","ama":"Montero J, Kilian B, Chan J, Bayliss P, Heisenberg C-PJ. Phosphoinositide 3-kinase is required for process outgrowth and cell polarization of gastrulating mesendodermal cells. <i>Current Biology</i>. 2003;13(15):1279-1289. doi:<a href=\"https://doi.org/10.1016/S0960-9822(03)00505-0\">10.1016/S0960-9822(03)00505-0</a>","chicago":"Montero, Juan, Beate Kilian, Joanne Chan, Peter Bayliss, and Carl-Philipp J Heisenberg. “Phosphoinositide 3-Kinase Is Required for Process Outgrowth and Cell Polarization of Gastrulating Mesendodermal Cells.” <i>Current Biology</i>. Cell Press, 2003. <a href=\"https://doi.org/10.1016/S0960-9822(03)00505-0\">https://doi.org/10.1016/S0960-9822(03)00505-0</a>."},"page":"1279 - 1289","title":"Phosphoinositide 3-kinase is required for process outgrowth and cell polarization of gastrulating mesendodermal cells","author":[{"first_name":"Juan","full_name":"Montero, Juan","last_name":"Montero"},{"first_name":"Beate","full_name":"Kilian, Beate","last_name":"Kilian"},{"first_name":"Joanne","full_name":"Chan, Joanne","last_name":"Chan"},{"first_name":"Peter","full_name":"Bayliss, Peter","last_name":"Bayliss"},{"first_name":"Carl-Philipp J","orcid":"0000-0002-0912-4566","full_name":"Heisenberg, Carl-Philipp J","last_name":"Heisenberg","id":"39427864-F248-11E8-B48F-1D18A9856A87"}],"publication":"Current Biology","fulldoi":"https://doi.org/10.1016/S0960-9822(03)00505-0","acknowledgement":"We would like to thank Jennifer Geiger, Juan Hurl& Hannu Mansu-koski, Florian Raible, Marino Zerial, Steve Wilson, and Kurt Anderson for critical reading of earlier versions of this manuscript. We thank Erez Raz, Bart Vanhaesebroeck, and Lukas Roth for sending us the pCS2-PH-GFP-nos, the p1IOCAAX, and the pCS2-actin-GFP constructs, respectively. We are grateful to Marino Zerial and his lab for encouraging us to start this work and providing us with the dnP13K construct and to Florian Ulrich and Franziska Friedrich for help with the confocal microscope and artwork, respectively. We thank Gunter Junghanns and Evelyn Lehmann for excellent fish care. C.-P.H. is supported by an Emmy-Noother-Fellowship from the Deutsche Forschungsgemeinschaft. ","issue":"15","publication_identifier":{"eissn":["1879-0445"],"issn":["0960-9822"]}},{"acknowledgement":"We thank Michael Brand, Florian Raible, Gerlinde Reim, Tobias Langenberg, Jennifer Geiger and Kate Poole for helpful comments on earlier versions of this manuscript. We are grateful to Henry Roehl and Christiane Nüsslein Volhard for sending us the ppt mutant stock. M.T. was supported by a Career Development Fellowship from the MRC. B.K., H.M. and C.P.H. are supported by an Emmy Noether-Fellowship from the DFG.","issue":"4","publication_identifier":{"issn":["0925-4773"]},"page":"467 - 476","title":"The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation","author":[{"first_name":"Beate","full_name":"Kilian, Beate","last_name":"Kilian"},{"last_name":"Mansukoski","full_name":"Mansukoski, Hannu","first_name":"Hannu"},{"last_name":"Barbosa","full_name":"Barbosa, Filipa","first_name":"Filipa"},{"last_name":"Ulrich","first_name":"Florian","full_name":"Ulrich, Florian"},{"last_name":"Tada","full_name":"Tada, Masazumi","first_name":"Masazumi"},{"full_name":"Heisenberg, Carl-Philipp J","first_name":"Carl-Philipp J","orcid":"0000-0002-0912-4566","last_name":"Heisenberg","id":"39427864-F248-11E8-B48F-1D18A9856A87"}],"publication":"Mechanisms of Development","fulldoi":"https://doi.org/10.1016/S0925-4773(03)00004-2","publisher":"Elsevier","volume":120,"citation":{"ama":"Kilian B, Mansukoski H, Barbosa F, Ulrich F, Tada M, Heisenberg C-PJ. The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation. <i>Mechanisms of Development</i>. 2003;120(4):467-476. doi:<a href=\"https://doi.org/10.1016/S0925-4773(03)00004-2\">10.1016/S0925-4773(03)00004-2</a>","ista":"Kilian B, Mansukoski H, Barbosa F, Ulrich F, Tada M, Heisenberg C-PJ. 2003. The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation. Mechanisms of Development. 120(4), 467–476.","chicago":"Kilian, Beate, Hannu Mansukoski, Filipa Barbosa, Florian Ulrich, Masazumi Tada, and Carl-Philipp J Heisenberg. “The Role of Ppt/Wnt5 in Regulating Cell Shape and Movement during Zebrafish Gastrulation.” <i>Mechanisms of Development</i>. Elsevier, 2003. <a href=\"https://doi.org/10.1016/S0925-4773(03)00004-2\">https://doi.org/10.1016/S0925-4773(03)00004-2</a>.","ieee":"B. Kilian, H. Mansukoski, F. Barbosa, F. Ulrich, M. Tada, and C.-P. J. Heisenberg, “The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation,” <i>Mechanisms of Development</i>, vol. 120, no. 4. Elsevier, pp. 467–476, 2003.","apa":"Kilian, B., Mansukoski, H., Barbosa, F., Ulrich, F., Tada, M., &#38; Heisenberg, C.-P. J. (2003). The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation. <i>Mechanisms of Development</i>. Elsevier. <a href=\"https://doi.org/10.1016/S0925-4773(03)00004-2\">https://doi.org/10.1016/S0925-4773(03)00004-2</a>","short":"B. Kilian, H. Mansukoski, F. Barbosa, F. Ulrich, M. Tada, C.-P.J. Heisenberg, Mechanisms of Development 120 (2003) 467–476.","mla":"Kilian, Beate, et al. “The Role of Ppt/Wnt5 in Regulating Cell Shape and Movement during Zebrafish Gastrulation.” <i>Mechanisms of Development</i>, vol. 120, no. 4, Elsevier, 2003, pp. 467–76, doi:<a href=\"https://doi.org/10.1016/S0925-4773(03)00004-2\">10.1016/S0925-4773(03)00004-2</a>."},"year":"2003","scopus_import":"1","pmid":1,"external_id":{"pmid":["12676324 "]},"date_updated":"2024-02-27T09:46:39Z","doi":"10.1016/S0925-4773(03)00004-2","date_created":"2018-12-11T12:07:27Z","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","intvolume":"       120","month":"04","quality_controlled":"1","day":"01","_id":"4185","type":"journal_article","article_type":"original","language":[{"iso":"eng"}],"publist_id":"1934","oa_version":"None","extern":"1","date_published":"2003-04-01T00:00:00Z","abstract":[{"lang":"eng","text":"Wnt genes play important roles in regulating patterning and morphogenesis during vertebrate gastrulation. In zebrafish, slb/wnt11 is required for convergence and extension movements, but not cell fate specification during gastrulation. To determine if other Wnt genes functionally interact with slb/wnt11, we analysed the role of ppt/wnt5 during zebrafish gastrulation. ppt/wnt5 is maternally provided and zygotically expressed at all stages during gastrulation. The analysis of ppt mutant embryos reveals that Ppt/Wnt5 regulates cell elongation and convergent extension movements in posterior regions of the gastrula, while its function in more anterior regions is largely redundant to that of Slb/Wnt11. Frizzled-2 functions downstream of ppt/wnt5, indicating that it might act as a receptor for Ppt/Wnt5 in this process. The characterisation of the role of Ppt/Wnt5 provides insight into the functional diversity of Wnt genes in regulating vertebrate gastrulation movements. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved."}],"publication_status":"published","status":"public","article_processing_charge":"No"},{"scopus_import":"1","doi":"10.1111/j.0014-3820.2003.tb01537.x","date_updated":"2024-01-23T10:21:57Z","pmid":1,"external_id":{"pmid":["12703935 "]},"publisher":"Wiley-Blackwell","volume":57,"year":"2003","citation":{"short":"A. Navarro, N.H. Barton, Evolution; International Journal of Organic Evolution 57 (2003) 447–459.","apa":"Navarro, A., &#38; Barton, N. H. (2003). Accumulating postzygotic isolation genes in parapatry: a new twist on chromosomal speciation. <i>Evolution; International Journal of Organic Evolution</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1111/j.0014-3820.2003.tb01537.x\">https://doi.org/10.1111/j.0014-3820.2003.tb01537.x</a>","mla":"Navarro, Arcadio, and Nicholas H. Barton. “Accumulating Postzygotic Isolation Genes in Parapatry: A New Twist on Chromosomal Speciation.” <i>Evolution; International Journal of Organic Evolution</i>, vol. 57, no. 3, Wiley-Blackwell, 2003, pp. 447–59, doi:<a href=\"https://doi.org/10.1111/j.0014-3820.2003.tb01537.x\">10.1111/j.0014-3820.2003.tb01537.x</a>.","ieee":"A. Navarro and N. H. Barton, “Accumulating postzygotic isolation genes in parapatry: a new twist on chromosomal speciation,” <i>Evolution; International Journal of Organic Evolution</i>, vol. 57, no. 3. Wiley-Blackwell, pp. 447–459, 2003.","ista":"Navarro A, Barton NH. 2003. Accumulating postzygotic isolation genes in parapatry: a new twist on chromosomal speciation. Evolution; International Journal of Organic Evolution. 57(3), 447–459.","ama":"Navarro A, Barton NH. Accumulating postzygotic isolation genes in parapatry: a new twist on chromosomal speciation. <i>Evolution; International Journal of Organic Evolution</i>. 2003;57(3):447-459. doi:<a href=\"https://doi.org/10.1111/j.0014-3820.2003.tb01537.x\">10.1111/j.0014-3820.2003.tb01537.x</a>","chicago":"Navarro, Arcadio, and Nicholas H Barton. “Accumulating Postzygotic Isolation Genes in Parapatry: A New Twist on Chromosomal Speciation.” <i>Evolution; International Journal of Organic Evolution</i>. Wiley-Blackwell, 2003. <a href=\"https://doi.org/10.1111/j.0014-3820.2003.tb01537.x\">https://doi.org/10.1111/j.0014-3820.2003.tb01537.x</a>."},"author":[{"last_name":"Navarro","full_name":"Navarro, Arcadio","first_name":"Arcadio"},{"last_name":"Barton","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","first_name":"Nicholas H","orcid":"0000-0002-8548-5240","full_name":"Barton, Nicholas H"}],"publication":"Evolution; International Journal of Organic Evolution","fulldoi":"https://doi.org/10.1111/j.0014-3820.2003.tb01537.x","title":"Accumulating postzygotic isolation genes in parapatry: a new twist on chromosomal speciation","page":"447 - 459","publication_identifier":{"issn":["0014-3820"]},"acknowledgement":"We thank A. Andrés, C. Bartolomé, J. Bertranpetit, F. Calafell, B. Charlesworth, D. Charlesworth, F. Depaulis, S. Gavrilets, T. Johnson, P. Keightley, M. Kirkpatrik, A. Kondrashov, H. Laayouni, X. Maside, M. Noor, D. Ortiz-Barrientos,\r\nL. Rieseberg, and T. Vines for valuable discussion and criticism. The detailed comments of B. Charlesworth, D. Charlesworth, and F. Depaulis greatly improved the original manuscript. AN is particularly grateful to X. Maside, who was a patient guide through the jungle of speciation. This work was supported by the NERC grant GR3/11635 (United Kingdom). AN is funded by the Ramón y Cajal Program (Spain).","issue":"3","status":"public","abstract":[{"lang":"eng","text":"Chromosomal rearrangements can promote reproductive isolation by reducing recombination along a large section of the genome. We model the effects of the genetic barrier to gene flow caused by a chromosomal rearrangement on the rate of accumulation of postzygotic isolation genes in parapatry. We find that, if reproductive isolation is produced by the accumulation in parapatry of sets of alleles compatible within but incompatible across species, chromosomal rearrangements are far more likely to favor it than classical genetic barriers without chromosomal changes. New evidence of the role of chromosomal rearrangements in parapatric speciation suggests that postzygotic isolation is often due to the accumulation of such incompatibilities. The model makes testable qualitative predictions about the genetic signature of speciation."}],"publication_status":"published","date_published":"2003-03-01T00:00:00Z","article_processing_charge":"No","oa_version":"None","extern":"1","publist_id":"1840","article_type":"original","language":[{"iso":"eng"}],"quality_controlled":"1","type":"journal_article","_id":"4254","day":"01","date_created":"2018-12-11T12:07:52Z","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","month":"03","intvolume":"        57"},{"type":"journal_article","_id":"4255","day":"11","quality_controlled":"1","intvolume":"       300","month":"04","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_created":"2018-12-11T12:07:53Z","article_processing_charge":"No","date_published":"2003-04-11T00:00:00Z","status":"public","abstract":[{"lang":"eng","text":"Humans and their closest evolutionary relatives, the chimpanzees, differ in ∼1.24% of their genomic DNA sequences. The fraction of these changes accumulated during the speciation processes that have separated the two lineages may be of special relevance in understanding the basis of their differences. We analyzed human and chimpanzee sequence data to search for the patterns of divergence and polymorphism predicted by a theoretical model of speciation. According to the model, positively selected changes should accumulate in chromosomes that present fixed structural differences, such as inversions, between the two species. Protein evolution was more than 2.2 times faster in chromosomes that had undergone structural rearrangements compared with colinear chromosomes. Also, nucleotide variability is slightly lower in rearranged chromosomes. These patterns of divergence and polymorphism may be, at least in part, the molecular footprint of speciation events in the human and chimpanzee lineages. "}],"publication_status":"published","extern":"1","oa_version":"None","language":[{"iso":"eng"}],"article_type":"original","publist_id":"1841","fulldoi":"https://doi.org/10.1126/science.1080600 ","publication":"Science","author":[{"first_name":"Arcadio","full_name":"Navarro, Arcadio","last_name":"Navarro"},{"id":"4880FE40-F248-11E8-B48F-1D18A9856A87","last_name":"Barton","first_name":"Nicholas H","orcid":"0000-0002-8548-5240","full_name":"Barton, Nicholas H"}],"page":"321 - 324","title":"Chromosomal speciation and molecular divergence -- Accelerated evolution in rearranged chromosomes","publication_identifier":{"issn":["0036-8075"]},"issue":"5617","external_id":{"pmid":[" 12690198"]},"pmid":1,"doi":"10.1126/science.1080600 ","date_updated":"2024-02-26T13:37:51Z","scopus_import":"1","year":"2003","citation":{"mla":"Navarro, Arcadio, and Nicholas H. Barton. “Chromosomal Speciation and Molecular Divergence -- Accelerated Evolution in Rearranged Chromosomes.” <i>Science</i>, vol. 300, no. 5617, American Association for the Advancement of Science, 2003, pp. 321–24, doi:<a href=\"https://doi.org/10.1126/science.1080600 \">10.1126/science.1080600 </a>.","apa":"Navarro, A., &#38; Barton, N. H. (2003). Chromosomal speciation and molecular divergence -- Accelerated evolution in rearranged chromosomes. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1080600 \">https://doi.org/10.1126/science.1080600 </a>","short":"A. Navarro, N.H. Barton, Science 300 (2003) 321–324.","chicago":"Navarro, Arcadio, and Nicholas H Barton. “Chromosomal Speciation and Molecular Divergence -- Accelerated Evolution in Rearranged Chromosomes.” <i>Science</i>. American Association for the Advancement of Science, 2003. <a href=\"https://doi.org/10.1126/science.1080600 \">https://doi.org/10.1126/science.1080600 </a>.","ista":"Navarro A, Barton NH. 2003. Chromosomal speciation and molecular divergence -- Accelerated evolution in rearranged chromosomes. Science. 300(5617), 321–324.","ama":"Navarro A, Barton NH. Chromosomal speciation and molecular divergence -- Accelerated evolution in rearranged chromosomes. <i>Science</i>. 2003;300(5617):321-324. doi:<a href=\"https://doi.org/10.1126/science.1080600 \">10.1126/science.1080600 </a>","ieee":"A. Navarro and N. H. Barton, “Chromosomal speciation and molecular divergence -- Accelerated evolution in rearranged chromosomes,” <i>Science</i>, vol. 300, no. 5617. American Association for the Advancement of Science, pp. 321–324, 2003."},"publisher":"American Association for the Advancement of Science","volume":300},{"author":[{"full_name":"Barton, Nicholas H","first_name":"Nicholas H","orcid":"0000-0002-8548-5240","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","last_name":"Barton"},{"last_name":"Zuidema","first_name":"Willem","full_name":"Zuidema, Willem"}],"publication":"Current Biology","fulldoi":"https://doi.org/10.1016/S0960-9822(03)00573-6","page":"R649 - R651","title":"The erratic path towards complexity","publication_identifier":{"issn":["0960-9822"]},"issue":"16","scopus_import":"1","doi":"10.1016/S0960-9822(03)00573-6","date_updated":"2024-01-23T09:41:33Z","publisher":"Cell Press","volume":13,"year":"2003","citation":{"chicago":"Barton, Nicholas H, and Willem Zuidema. “The Erratic Path towards Complexity.” <i>Current Biology</i>. Cell Press, 2003. <a href=\"https://doi.org/10.1016/S0960-9822(03)00573-6\">https://doi.org/10.1016/S0960-9822(03)00573-6</a>.","ista":"Barton NH, Zuidema W. 2003. The erratic path towards complexity. Current Biology. 13(16), R649–R651.","ama":"Barton NH, Zuidema W. The erratic path towards complexity. <i>Current Biology</i>. 2003;13(16):R649-R651. doi:<a href=\"https://doi.org/10.1016/S0960-9822(03)00573-6\">10.1016/S0960-9822(03)00573-6</a>","ieee":"N. H. Barton and W. Zuidema, “The erratic path towards complexity,” <i>Current Biology</i>, vol. 13, no. 16. Cell Press, pp. R649–R651, 2003.","mla":"Barton, Nicholas H., and Willem Zuidema. “The Erratic Path towards Complexity.” <i>Current Biology</i>, vol. 13, no. 16, Cell Press, 2003, pp. R649–51, doi:<a href=\"https://doi.org/10.1016/S0960-9822(03)00573-6\">10.1016/S0960-9822(03)00573-6</a>.","apa":"Barton, N. H., &#38; Zuidema, W. (2003). The erratic path towards complexity. <i>Current Biology</i>. Cell Press. <a href=\"https://doi.org/10.1016/S0960-9822(03)00573-6\">https://doi.org/10.1016/S0960-9822(03)00573-6</a>","short":"N.H. Barton, W. Zuidema, Current Biology 13 (2003) R649–R651."},"quality_controlled":"1","type":"journal_article","_id":"4256","day":"19","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_created":"2018-12-11T12:07:53Z","intvolume":"        13","month":"08","date_published":"2003-08-19T00:00:00Z","publication_status":"published","abstract":[{"lang":"eng","text":"Artificial Life models may shed new light on the long-standing challenge for evolutionary biology of explaining the origins of complex organs. Real progress on this issue, however, requires Artificial Life researchers to take seriously the tools and insights from population genetics."}],"status":"public","article_processing_charge":"No","oa_version":"Published Version","extern":"1","article_type":"original","language":[{"iso":"eng"}],"publist_id":"1838"},{"date_created":"2018-12-11T12:07:53Z","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","intvolume":"        34","publication_identifier":{"issn":["1543-592X"]},"month":"11","page":"99 - 125","quality_controlled":"1","title":"The effects of genetic and geographic structure on neutral variation","day":"01","_id":"4257","type":"journal_article","publication":"Annual Review of Ecology and Systematics","author":[{"first_name":"Brian","full_name":"Charlesworth, Brian","last_name":"Charlesworth"},{"last_name":"Charlesworth","first_name":"Deborah","full_name":"Charlesworth, Deborah"},{"last_name":"Barton","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","first_name":"Nicholas H","orcid":"0000-0002-8548-5240","full_name":"Barton, Nicholas H"}],"fulldoi":"https://doi.org/10.1146/annurev.ecolsys.34.011802.132359","language":[{"iso":"eng"}],"article_type":"original","publist_id":"1839","volume":34,"publisher":"Annual Reviews","year":"2003","citation":{"mla":"Charlesworth, Brian, et al. “The Effects of Genetic and Geographic Structure on Neutral Variation.” <i>Annual Review of Ecology and Systematics</i>, vol. 34, Annual Reviews, 2003, pp. 99–125, doi:<a href=\"https://doi.org/10.1146/annurev.ecolsys.34.011802.132359\">10.1146/annurev.ecolsys.34.011802.132359</a>.","apa":"Charlesworth, B., Charlesworth, D., &#38; Barton, N. H. (2003). The effects of genetic and geographic structure on neutral variation. <i>Annual Review of Ecology and Systematics</i>. Annual Reviews. <a href=\"https://doi.org/10.1146/annurev.ecolsys.34.011802.132359\">https://doi.org/10.1146/annurev.ecolsys.34.011802.132359</a>","short":"B. Charlesworth, D. Charlesworth, N.H. Barton, Annual Review of Ecology and Systematics 34 (2003) 99–125.","chicago":"Charlesworth, Brian, Deborah Charlesworth, and Nicholas H Barton. “The Effects of Genetic and Geographic Structure on Neutral Variation.” <i>Annual Review of Ecology and Systematics</i>. Annual Reviews, 2003. <a href=\"https://doi.org/10.1146/annurev.ecolsys.34.011802.132359\">https://doi.org/10.1146/annurev.ecolsys.34.011802.132359</a>.","ista":"Charlesworth B, Charlesworth D, Barton NH. 2003. The effects of genetic and geographic structure on neutral variation. Annual Review of Ecology and Systematics. 34, 99–125.","ama":"Charlesworth B, Charlesworth D, Barton NH. The effects of genetic and geographic structure on neutral variation. <i>Annual Review of Ecology and Systematics</i>. 2003;34:99-125. doi:<a href=\"https://doi.org/10.1146/annurev.ecolsys.34.011802.132359\">10.1146/annurev.ecolsys.34.011802.132359</a>","ieee":"B. Charlesworth, D. Charlesworth, and N. H. Barton, “The effects of genetic and geographic structure on neutral variation,” <i>Annual Review of Ecology and Systematics</i>, vol. 34. Annual Reviews, pp. 99–125, 2003."},"oa_version":"None","doi":"10.1146/annurev.ecolsys.34.011802.132359","date_updated":"2024-01-23T10:15:44Z","extern":"1","date_published":"2003-11-01T00:00:00Z","status":"public","abstract":[{"text":"Variation within a species may be structured both geographically and by genetic background. We review the effects of such structuring on neutral variants, using a framework based on the coalescent process. Short-term effects of sex differences and age structure can be averaged out using fast timescale approximations, allowing a simple general treatment of effective population size and migration. We consider the effects of geographic structure on variation within and between local populations, first in general terms, and then for specific migration models. We discuss the close parallels between geographic structure and stable types of genetic structure caused by selection, including balancing selection and background selection. The effects of departures from stability, such as selective sweeps and population bottlenecks, are also described. Methods for distinguishing population history from the effects of ongoing gene flow are discussed. We relate the theoretical results to observed patterns of variation in natural populations.","lang":"eng"}],"publication_status":"published","article_processing_charge":"No"}]