[{"publication_status":"published","quality_controlled":"1","oa":1,"publisher":"Internet Mathematics","author":[{"id":"540c9bbd-f2de-11ec-812d-d04a5be85630","first_name":"Monika H","last_name":"Henzinger","orcid":"0000-0002-5008-6530","full_name":"Henzinger, Monika H"}],"_id":"11762","page":"115-123","date_updated":"2024-11-06T08:13:59Z","main_file_link":[{"url":"https://doi.org/10.1080/15427951.2004.10129079","open_access":"1"}],"day":"01","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","abstract":[{"lang":"eng","text":"In this paper, we describe six algorithmic problems that arise in web search engines and that are not or only partially solved: (1) Uniformly sampling of web pages; (2) modeling the web graph; (3) finding duplicate hosts; (4) finding top gainers and losers in data streams; (5) finding large dense bipartite graphs; and (6) understanding how eigenvectors partition the web."}],"volume":1,"month":"01","article_processing_charge":"No","article_type":"original","date_created":"2022-08-08T11:55:53Z","citation":{"short":"M. Henzinger, Internet Mathematics 1 (2004) 115–123.","ama":"Henzinger M. Algorithmic challenges in web search engines. <i>Internet Mathematics</i>. 2004;1(1):115-123. doi:<a href=\"https://doi.org/10.1080/15427951.2004.10129079\">10.1080/15427951.2004.10129079</a>","ista":"Henzinger M. 2004. Algorithmic challenges in web search engines. Internet Mathematics. 1(1), 115–123.","ieee":"M. Henzinger, “Algorithmic challenges in web search engines,” <i>Internet Mathematics</i>, vol. 1, no. 1. Internet Mathematics, pp. 115–123, 2004.","chicago":"Henzinger, Monika. “Algorithmic Challenges in Web Search Engines.” <i>Internet Mathematics</i>. Internet Mathematics, 2004. <a href=\"https://doi.org/10.1080/15427951.2004.10129079\">https://doi.org/10.1080/15427951.2004.10129079</a>.","mla":"Henzinger, Monika. “Algorithmic Challenges in Web Search Engines.” <i>Internet Mathematics</i>, vol. 1, no. 1, Internet Mathematics, 2004, pp. 115–23, doi:<a href=\"https://doi.org/10.1080/15427951.2004.10129079\">10.1080/15427951.2004.10129079</a>.","apa":"Henzinger, M. (2004). Algorithmic challenges in web search engines. <i>Internet Mathematics</i>. Internet Mathematics. <a href=\"https://doi.org/10.1080/15427951.2004.10129079\">https://doi.org/10.1080/15427951.2004.10129079</a>"},"extern":"1","oa_version":"Published Version","doi":"10.1080/15427951.2004.10129079","type":"journal_article","publication":"Internet Mathematics","language":[{"iso":"eng"}],"date_published":"2004-01-01T00:00:00Z","scopus_import":"1","intvolume":"         1","year":"2004","issue":"1","publication_identifier":{"eissn":["1944-9488"],"issn":["1542-7951"]},"title":"Algorithmic challenges in web search engines"},{"citation":{"ama":"Henzinger M. The past, present, and future of web search engines. In: <i>31st International Colloquium on Automata, Languages and Programming</i>. Vol 3142. Springer Nature; 2004:3. doi:<a href=\"https://doi.org/10.1007/978-3-540-27836-8_2\">10.1007/978-3-540-27836-8_2</a>","short":"M. Henzinger, in:, 31st International Colloquium on Automata, Languages and Programming, Springer Nature, 2004, p. 3.","ista":"Henzinger M. 2004. The past, present, and future of web search engines. 31st International Colloquium on Automata, Languages and Programming. ICALP: International Colloquium on Automata, Languages, and Programming, LNCS, vol. 3142, 3.","ieee":"M. Henzinger, “The past, present, and future of web search engines,” in <i>31st International Colloquium on Automata, Languages and Programming</i>, Turku, Finland, 2004, vol. 3142, p. 3.","mla":"Henzinger, Monika. “The Past, Present, and Future of Web Search Engines.” <i>31st International Colloquium on Automata, Languages and Programming</i>, vol. 3142, Springer Nature, 2004, p. 3, doi:<a href=\"https://doi.org/10.1007/978-3-540-27836-8_2\">10.1007/978-3-540-27836-8_2</a>.","apa":"Henzinger, M. (2004). The past, present, and future of web search engines. In <i>31st International Colloquium on Automata, Languages and Programming</i> (Vol. 3142, p. 3). Turku, Finland: Springer Nature. <a href=\"https://doi.org/10.1007/978-3-540-27836-8_2\">https://doi.org/10.1007/978-3-540-27836-8_2</a>","chicago":"Henzinger, Monika. “The Past, Present, and Future of Web Search Engines.” In <i>31st International Colloquium on Automata, Languages and Programming</i>, 3142:3. Springer Nature, 2004. <a href=\"https://doi.org/10.1007/978-3-540-27836-8_2\">https://doi.org/10.1007/978-3-540-27836-8_2</a>."},"publisher":"Springer Nature","extern":"1","alternative_title":["LNCS"],"_id":"11800","oa_version":"None","author":[{"first_name":"Monika H","id":"540c9bbd-f2de-11ec-812d-d04a5be85630","orcid":"0000-0002-5008-6530","last_name":"Henzinger","full_name":"Henzinger, Monika H"}],"conference":{"end_date":"2004-07-16","location":"Turku, Finland","name":"ICALP: International Colloquium on Automata, Languages, and Programming","start_date":"2004-07-12"},"date_created":"2022-08-11T12:38:58Z","quality_controlled":"1","volume":3142,"month":"07","abstract":[{"lang":"eng","text":"Web search engines have emerged as one of the central applications on the Internet. In fact, search has become one of the most important activities that people engage in on the the Internet. Even beyond becoming the number one source of information, a growing number of businesses are depending on web search engines for customer acquisition.\r\n\r\nThe first generation of web search engines used text-only retrieval techniques. Google revolutionized the field by deploying the PageRank technology – an eigenvector-based analysis of the hyperlink structure – to analyze the web in order to produce relevant results. Moving forward, our goal is to achieve a better understanding of a page with a view towards producing even more relevant results."}],"article_processing_charge":"No","status":"public","publication_status":"published","publication_identifier":{"eissn":["1611-3349"],"issn":["0302-9743"]},"title":"The past, present, and future of web search engines","intvolume":"      3142","year":"2004","day":"01","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","type":"conference","date_published":"2004-07-01T00:00:00Z","publication":"31st International Colloquium on Automata, Languages and Programming","language":[{"iso":"eng"}],"scopus_import":"1","page":"3","date_updated":"2024-11-06T08:14:51Z","doi":"10.1007/978-3-540-27836-8_2"},{"status":"public","publication_status":"published","quality_controlled":"1","abstract":[{"lang":"eng","text":"Web search engines have emerged as one of the central applications on the internet. In fact, search has become one of the most important activities that people engage in on the Internet. Even beyond becoming the number one source of information, a growing number of businesses are depending on web search engines for customer acquisition. In this talk I will brief review the history of web search engines: The first generation of web search engines used text-only retrieval techniques. Google revolutionized the field by deploying the PageRank technology – an eigenvector-based analysis of the hyperlink structure- to analyze the web in order to produce relevant results. Moving forward, our goal is to achieve a better understanding of a page with a view towards producing even more relevant results.\r\n\r\nGoogle is powered by a large number of PCs. Using this infrastructure and striving to be as efficient as possible poses challenging systems problems but also various algorithmic challenges. I will discuss some of them in my talk."}],"month":"09","volume":3221,"article_processing_charge":"No","conference":{"location":"Bergen, Norway","end_date":"2004-09-17","name":"ESA: European Symposium on Algorithms","start_date":"2004-09-14"},"date_created":"2022-08-11T13:18:05Z","citation":{"ieee":"M. Henzinger, “Algorithmic aspects of web search engines,” in <i>2th Annual European Symposium on Algorithms</i>, Bergen, Norway, 2004, vol. 3221, p. 3.","ista":"Henzinger M. 2004. Algorithmic aspects of web search engines. 2th Annual European Symposium on Algorithms. ESA: European Symposium on Algorithms, LNCS, vol. 3221, 3.","chicago":"Henzinger, Monika. “Algorithmic Aspects of Web Search Engines.” In <i>2th Annual European Symposium on Algorithms</i>, 3221:3. Springer Nature, 2004. <a href=\"https://doi.org/10.1007/978-3-540-30140-0_2\">https://doi.org/10.1007/978-3-540-30140-0_2</a>.","apa":"Henzinger, M. (2004). Algorithmic aspects of web search engines. In <i>2th Annual European Symposium on Algorithms</i> (Vol. 3221, p. 3). Bergen, Norway: Springer Nature. <a href=\"https://doi.org/10.1007/978-3-540-30140-0_2\">https://doi.org/10.1007/978-3-540-30140-0_2</a>","mla":"Henzinger, Monika. “Algorithmic Aspects of Web Search Engines.” <i>2th Annual European Symposium on Algorithms</i>, vol. 3221, Springer Nature, 2004, p. 3, doi:<a href=\"https://doi.org/10.1007/978-3-540-30140-0_2\">10.1007/978-3-540-30140-0_2</a>.","short":"M. Henzinger, in:, 2th Annual European Symposium on Algorithms, Springer Nature, 2004, p. 3.","ama":"Henzinger M. Algorithmic aspects of web search engines. In: <i>2th Annual European Symposium on Algorithms</i>. Vol 3221. Springer Nature; 2004:3. doi:<a href=\"https://doi.org/10.1007/978-3-540-30140-0_2\">10.1007/978-3-540-30140-0_2</a>"},"publisher":"Springer Nature","extern":"1","alternative_title":["LNCS"],"author":[{"full_name":"Henzinger, Monika H","last_name":"Henzinger","orcid":"0000-0002-5008-6530","first_name":"Monika H","id":"540c9bbd-f2de-11ec-812d-d04a5be85630"}],"_id":"11801","oa_version":"None","page":"3","date_updated":"2024-11-06T11:55:33Z","doi":"10.1007/978-3-540-30140-0_2","type":"conference","date_published":"2004-09-01T00:00:00Z","language":[{"iso":"eng"}],"publication":"2th Annual European Symposium on Algorithms","scopus_import":"1","intvolume":"      3221","day":"01","year":"2004","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"issn":["0302-9743"],"eissn":["1611-3349"],"isbn":[" 3540230254"]},"title":"Algorithmic aspects of web search engines"},{"publication_identifier":{"issn":["0277-786X"]},"title":"The past, present, and future of web information retrieval","intvolume":"      5296","day":"01","year":"2004","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","type":"conference","date_published":"2004-01-01T00:00:00Z","language":[{"iso":"eng"}],"publication":"SPIE Proceedings","scopus_import":"1","page":"23 - 26","date_updated":"2024-11-06T11:59:44Z","doi":"10.1117/12.537534","citation":{"chicago":"Henzinger, Monika. “The Past, Present, and Future of Web Information Retrieval.” In <i>SPIE Proceedings</i>, 5296:23–26. Society of Photo-Optical Instrumentation Engineers, 2004. <a href=\"https://doi.org/10.1117/12.537534\">https://doi.org/10.1117/12.537534</a>.","apa":"Henzinger, M. (2004). The past, present, and future of web information retrieval. In <i>SPIE Proceedings</i> (Vol. 5296, pp. 23–26). San Jose, CA, United States: Society of Photo-Optical Instrumentation Engineers. <a href=\"https://doi.org/10.1117/12.537534\">https://doi.org/10.1117/12.537534</a>","mla":"Henzinger, Monika. “The Past, Present, and Future of Web Information Retrieval.” <i>SPIE Proceedings</i>, vol. 5296, Society of Photo-Optical Instrumentation Engineers, 2004, pp. 23–26, doi:<a href=\"https://doi.org/10.1117/12.537534\">10.1117/12.537534</a>.","ieee":"M. Henzinger, “The past, present, and future of web information retrieval,” in <i>SPIE Proceedings</i>, San Jose, CA, United States, 2004, vol. 5296, pp. 23–26.","ista":"Henzinger M. 2004. The past, present, and future of web information retrieval. SPIE Proceedings. Document Recognition and Retrieval XI vol. 5296, 23–26.","short":"M. Henzinger, in:, SPIE Proceedings, Society of Photo-Optical Instrumentation Engineers, 2004, pp. 23–26.","ama":"Henzinger M. The past, present, and future of web information retrieval. In: <i>SPIE Proceedings</i>. Vol 5296. Society of Photo-Optical Instrumentation Engineers; 2004:23-26. doi:<a href=\"https://doi.org/10.1117/12.537534\">10.1117/12.537534</a>"},"extern":"1","publisher":"Society of Photo-Optical Instrumentation Engineers","author":[{"full_name":"Henzinger, Monika H","orcid":"0000-0002-5008-6530","last_name":"Henzinger","id":"540c9bbd-f2de-11ec-812d-d04a5be85630","first_name":"Monika H"}],"_id":"11859","oa_version":"None","conference":{"end_date":"2004-01-22","location":"San Jose, CA, United States","start_date":"2004-01-21","name":"Document Recognition and Retrieval XI"},"date_created":"2022-08-16T08:46:41Z","quality_controlled":"1","month":"01","volume":5296,"abstract":[{"text":"In this article we describe the approach taken by the first web search engines, discuss the state of the art, and present some of the challenges for the future.","lang":"eng"}],"article_processing_charge":"No","status":"public","publication_status":"published"},{"status":"public","month":"04","abstract":[{"text":"The World Wide Web provides a unprecedented opportunity to automatically analyze a large sample of interests and activity in the world. We discuss methods for extracting knowledge from the web by randomly sampling and analyzing hosts and pages, and by analyzing the link structure of the web and how links accumulate over time. A variety of interesting and valuable information can be extracted, such as the distribution of web pages over domains, the distribution of interest in different areas, communities related to different topics, the nature of competition in different categories of sites, and the degree of communication between different communities or countries.","lang":"eng"}],"volume":101,"article_processing_charge":"No","article_type":"original","date_created":"2022-08-16T13:06:10Z","citation":{"short":"M. Henzinger, S. Lawrence, Proceedings of the National Academy of Sciences 101 (2004) 5186–5191.","ama":"Henzinger M, Lawrence S. Extracting knowledge from the World Wide Web. <i>Proceedings of the National Academy of Sciences</i>. 2004;101(suppl_1):5186-5191. doi:<a href=\"https://doi.org/10.1073/pnas.0307528100\">10.1073/pnas.0307528100</a>","ieee":"M. Henzinger and S. Lawrence, “Extracting knowledge from the World Wide Web,” <i>Proceedings of the National Academy of Sciences</i>, vol. 101, no. suppl_1. Proceedings of the National Academy of Sciences, pp. 5186–5191, 2004.","ista":"Henzinger M, Lawrence S. 2004. Extracting knowledge from the World Wide Web. Proceedings of the National Academy of Sciences. 101(suppl_1), 5186–5191.","chicago":"Henzinger, Monika, and Steve Lawrence. “Extracting Knowledge from the World Wide Web.” <i>Proceedings of the National Academy of Sciences</i>. Proceedings of the National Academy of Sciences, 2004. <a href=\"https://doi.org/10.1073/pnas.0307528100\">https://doi.org/10.1073/pnas.0307528100</a>.","mla":"Henzinger, Monika, and Steve Lawrence. “Extracting Knowledge from the World Wide Web.” <i>Proceedings of the National Academy of Sciences</i>, vol. 101, no. suppl_1, Proceedings of the National Academy of Sciences, 2004, pp. 5186–91, doi:<a href=\"https://doi.org/10.1073/pnas.0307528100\">10.1073/pnas.0307528100</a>.","apa":"Henzinger, M., &#38; Lawrence, S. (2004). Extracting knowledge from the World Wide Web. <i>Proceedings of the National Academy of Sciences</i>. Proceedings of the National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.0307528100\">https://doi.org/10.1073/pnas.0307528100</a>"},"extern":"1","oa_version":"Published Version","doi":"10.1073/pnas.0307528100","type":"journal_article","date_published":"2004-04-06T00:00:00Z","publication":"Proceedings of the National Academy of Sciences","language":[{"iso":"eng"}],"scopus_import":"1","intvolume":"       101","year":"2004","issue":"suppl_1","pmid":1,"publication_identifier":{"issn":["0027-8424"],"eissn":["1091-6490"]},"title":"Extracting knowledge from the World Wide Web","publication_status":"published","quality_controlled":"1","oa":1,"publisher":"Proceedings of the National Academy of Sciences","_id":"11877","author":[{"full_name":"Henzinger, Monika H","orcid":"0000-0002-5008-6530","last_name":"Henzinger","id":"540c9bbd-f2de-11ec-812d-d04a5be85630","first_name":"Monika H"},{"last_name":"Lawrence","full_name":"Lawrence, Steve","first_name":"Steve"}],"page":"5186-5191","date_updated":"2024-11-06T12:00:20Z","main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC387294/","open_access":"1"}],"external_id":{"pmid":["14745041"]},"day":"06","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"},{"author":[{"last_name":"Novarino","orcid":"0000-0002-7673-7178","full_name":"Gaia Novarino","first_name":"Gaia","id":"3E57A680-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Fabrizi","full_name":"Fabrizi, Cinzia","first_name":"Cinzia"},{"last_name":"Tonini","full_name":"Tonini, Raffaella","first_name":"Raffaella"},{"full_name":"Denti, Michela A","last_name":"Denti","first_name":"Michela"},{"first_name":"Albedi","full_name":"Malchiodi, Albedi F","last_name":"Malchiodi"},{"first_name":"Giuliana","last_name":"Lauro","full_name":"Lauro, Giuliana M"},{"last_name":"Sacchetti","full_name":"Sacchetti, Benedetto","first_name":"Benedetto"},{"first_name":"Silvia","last_name":"Paradisi","full_name":"Paradisi, Silvia"},{"full_name":"Ferroni, Arnaldo","last_name":"Ferroni","first_name":"Arnaldo"},{"first_name":"Paul","full_name":"Curmi, Paul M G","last_name":"Curmi"},{"first_name":"Samuel","last_name":"Breit","full_name":"Breit, Samuel N"},{"full_name":"Mazzanti, Michele","last_name":"Mazzanti","first_name":"Michele"}],"_id":"2308","citation":{"ama":"Novarino G, Fabrizi C, Tonini R, et al. Involvement of the intracellular ion channel CLIC1 in microglia-mediated β-amyloid-induced neurotoxicity. <i>Journal of Neuroscience</i>. 2004;24(23):5322-5330. doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.1170-04.2004\">10.1523/JNEUROSCI.1170-04.2004</a>","short":"G. Novarino, C. Fabrizi, R. Tonini, M. Denti, A. Malchiodi, G. Lauro, B. Sacchetti, S. Paradisi, A. Ferroni, P. Curmi, S. Breit, M. Mazzanti, Journal of Neuroscience 24 (2004) 5322–5330.","ieee":"G. Novarino <i>et al.</i>, “Involvement of the intracellular ion channel CLIC1 in microglia-mediated β-amyloid-induced neurotoxicity,” <i>Journal of Neuroscience</i>, vol. 24, no. 23. Society for Neuroscience, pp. 5322–5330, 2004.","ista":"Novarino G, Fabrizi C, Tonini R, Denti M, Malchiodi A, Lauro G, Sacchetti B, Paradisi S, Ferroni A, Curmi P, Breit S, Mazzanti M. 2004. Involvement of the intracellular ion channel CLIC1 in microglia-mediated β-amyloid-induced neurotoxicity. Journal of Neuroscience. 24(23), 5322–5330.","apa":"Novarino, G., Fabrizi, C., Tonini, R., Denti, M., Malchiodi, A., Lauro, G., … Mazzanti, M. (2004). Involvement of the intracellular ion channel CLIC1 in microglia-mediated β-amyloid-induced neurotoxicity. <i>Journal of Neuroscience</i>. Society for Neuroscience. <a href=\"https://doi.org/10.1523/JNEUROSCI.1170-04.2004\">https://doi.org/10.1523/JNEUROSCI.1170-04.2004</a>","mla":"Novarino, Gaia, et al. “Involvement of the Intracellular Ion Channel CLIC1 in Microglia-Mediated β-Amyloid-Induced Neurotoxicity.” <i>Journal of Neuroscience</i>, vol. 24, no. 23, Society for Neuroscience, 2004, pp. 5322–30, doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.1170-04.2004\">10.1523/JNEUROSCI.1170-04.2004</a>.","chicago":"Novarino, Gaia, Cinzia Fabrizi, Raffaella Tonini, Michela Denti, Albedi Malchiodi, Giuliana Lauro, Benedetto Sacchetti, et al. “Involvement of the Intracellular Ion Channel CLIC1 in Microglia-Mediated β-Amyloid-Induced Neurotoxicity.” <i>Journal of Neuroscience</i>. Society for Neuroscience, 2004. <a href=\"https://doi.org/10.1523/JNEUROSCI.1170-04.2004\">https://doi.org/10.1523/JNEUROSCI.1170-04.2004</a>."},"publisher":"Society for Neuroscience","extern":1,"date_created":"2018-12-11T11:56:54Z","abstract":[{"lang":"eng","text":"It is widely believed that the inflammatory events mediated by microglial activation contribute to several neurodegenerative processes. Alzheimer's disease, for example, is characterized by an accumulation of β-amyloid protein (Aβ) in neuritic plaques that are infiltrated by reactive microglia and astrocytes. Although Aβ and its fragment 25-35 exert a direct toxic effect on neurons, they also activate microglia. Microglial activation is accompanied by morphological changes, cell proliferation, and release of various cytokines and growth factors. A number of scientific reports suggest that the increased proliferation of microglial cells is dependent on ionic membrane currents and in particular on chloride conductances. An unusual chloride ion channel known to be associated with macrophage activation is the chloride intracellular channel-1 (CLIC1). Here we show that Aβ stimulation of neonatal rat microglia specifically leads to the increase in CLIC1 protein and to the functional expression of CLIC1 chloride conductance, both barely detectable on the plasma membrane of quiescent cells. CLIC1 protein expression in microglia increases after 24 hr of incubation with Aβ, simultaneously with the production of reactive nitrogen intermediates and of tumor necrosis factor-α (TNF-α). We demonstrate that reducing CLIC1 chloride conductance by a specific blocker [IAA-94 (R(+)-[(6,7-dichloro-2-cyclopentyl-2,3-dihydro-2-methyl-1-oxo-1H-inden-5yl)-oxy] acetic acid)] prevents neuronal apoptosis in neurons cocultured with Aβ-treated microglia. Furthermore, we show that small interfering RNAs used to knock down CLIC1 expression prevent TNF-α release induced by Aβ stimulation. These results provide a direct link between Aβ-induced microglial activation and CLIC1 functional expression."}],"volume":24,"month":"06","quality_controlled":0,"publist_id":"4620","publication_status":"published","status":"public","title":"Involvement of the intracellular ion channel CLIC1 in microglia-mediated β-amyloid-induced neurotoxicity","issue":"23","intvolume":"        24","day":"09","year":"2004","publication":"Journal of Neuroscience","date_published":"2004-06-09T00:00:00Z","type":"journal_article","date_updated":"2021-01-12T06:56:41Z","doi":"10.1523/JNEUROSCI.1170-04.2004","page":"5322 - 5330"},{"volume":115,"abstract":[{"lang":"eng","text":"The BMV conjecture for traces, which states that Tr exp(A - λB) is the Laplace transform of a positive measure, is shown to be equivalent to two other statements: (i) The polynomial λ → Tr(A + λB) p has only non-negative coefficients for all A, B ≥ 0, p ∈ ℕ and (ii) λ → Tr(A + λB)-p is the Laplace transform of a positive measure for A, B ≥ 0, p &gt; 0."}],"month":"04","quality_controlled":0,"publist_id":"4568","status":"public","publication_status":"published","author":[{"first_name":"Élliott","full_name":"Lieb, Élliott H","last_name":"Lieb"},{"id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","first_name":"Robert","full_name":"Robert Seiringer","last_name":"Seiringer","orcid":"0000-0002-6781-0521"}],"_id":"2355","citation":{"short":"É. Lieb, R. Seiringer, Journal of Statistical Physics 115 (2004) 185–190.","ama":"Lieb É, Seiringer R.  Equivalent forms of the Bessis-Moussa-Villani conjecture. <i>Journal of Statistical Physics</i>. 2004;115(1-2):185-190. doi:<a href=\"https://doi.org/10.1023/B:JOSS.0000019811.15510.27\">10.1023/B:JOSS.0000019811.15510.27</a>","chicago":"Lieb, Élliott, and Robert Seiringer. “ Equivalent Forms of the Bessis-Moussa-Villani Conjecture.” <i>Journal of Statistical Physics</i>. Springer, 2004. <a href=\"https://doi.org/10.1023/B:JOSS.0000019811.15510.27\">https://doi.org/10.1023/B:JOSS.0000019811.15510.27</a>.","mla":"Lieb, Élliott, and Robert Seiringer. “ Equivalent Forms of the Bessis-Moussa-Villani Conjecture.” <i>Journal of Statistical Physics</i>, vol. 115, no. 1–2, Springer, 2004, pp. 185–90, doi:<a href=\"https://doi.org/10.1023/B:JOSS.0000019811.15510.27\">10.1023/B:JOSS.0000019811.15510.27</a>.","apa":"Lieb, É., &#38; Seiringer, R. (2004).  Equivalent forms of the Bessis-Moussa-Villani conjecture. <i>Journal of Statistical Physics</i>. Springer. <a href=\"https://doi.org/10.1023/B:JOSS.0000019811.15510.27\">https://doi.org/10.1023/B:JOSS.0000019811.15510.27</a>","ieee":"É. Lieb and R. Seiringer, “ Equivalent forms of the Bessis-Moussa-Villani conjecture,” <i>Journal of Statistical Physics</i>, vol. 115, no. 1–2. Springer, pp. 185–190, 2004.","ista":"Lieb É, Seiringer R. 2004.  Equivalent forms of the Bessis-Moussa-Villani conjecture. Journal of Statistical Physics. 115(1–2), 185–190."},"publisher":"Springer","extern":1,"date_created":"2018-12-11T11:57:11Z","oa":1,"publication":"Journal of Statistical Physics","date_published":"2004-04-01T00:00:00Z","main_file_link":[{"url":"http://arxiv.org/abs/math-ph/0210027","open_access":"1"}],"type":"journal_article","date_updated":"2021-01-12T06:56:59Z","doi":"10.1023/B:JOSS.0000019811.15510.27","page":"185 - 190","title":" Equivalent forms of the Bessis-Moussa-Villani conjecture","issue":"1-2","intvolume":"       115","day":"01","year":"2004"},{"type":"journal_article","main_file_link":[{"open_access":"1","url":"http://arxiv.org/abs/math-ph/0305025"}],"date_published":"2004-01-01T00:00:00Z","publication":"Communications in Mathematical Physics","page":"347 - 393","doi":"10.1007/s00220-003-0993-3","date_updated":"2021-01-12T06:56:59Z","title":"One-dimensional behavior of dilute, trapped Bose gases","day":"01","year":"2004","intvolume":"       244","issue":"2","quality_controlled":0,"abstract":[{"text":"Recent experimental and theoretical work has shown that there are conditions in which a trapped, low-density Bose gas behaves like the one-dimensional delta-function Bose gas solved years ago by Lieb and Liniger. This is an intrinsically quantum-mechanical phenomenon because it is not necessary to have a trap width that is the size of an atom - as might have been supposed - but it suffices merely to have a trap width such that the energy gap for motion in the transverse direction is large compared to the energy associated with the motion along the trap. Up to now the theoretical arguments have been based on variational - perturbative ideas or numerical investigations. In contrast, this paper gives a rigorous proof of the one-dimensional behavior as far as the ground state energy and particle density are concerned. There are four parameters involved: the particle number, N, transverse and longitudinal dimensions of the trap, r and L, and the scattering length a of the interaction potential. Our main result is that if r/L → 0 and N → ∞ the ground state energy and density can be obtained by minimizing a one-dimensional density functional involving the Lieb-Liniger energy density with coupling constant ∼ a/r 2. This density functional simplifies in various limiting cases and we identify five asymptotic parameter regions altogether. Three of these, corresponding to the weak coupling regime, can also be obtained as limits of a three-dimensional Gross-Pitaevskii theory. We also show that Bose-Einstein condensation in the ground state persists in a part of this regime. In the strong coupling regime the longitudinal motion of the particles is strongly correlated. The Gross-Pitaevskii description is not valid in this regime and new mathematical methods come into play.","lang":"eng"}],"volume":244,"month":"01","publication_status":"published","status":"public","publist_id":"4569","publisher":"Springer","extern":1,"citation":{"short":"É. Lieb, R. Seiringer, J. Yngvason, Communications in Mathematical Physics 244 (2004) 347–393.","ama":"Lieb É, Seiringer R, Yngvason J. One-dimensional behavior of dilute, trapped Bose gases. <i>Communications in Mathematical Physics</i>. 2004;244(2):347-393. doi:<a href=\"https://doi.org/10.1007/s00220-003-0993-3\">10.1007/s00220-003-0993-3</a>","ieee":"É. Lieb, R. Seiringer, and J. Yngvason, “One-dimensional behavior of dilute, trapped Bose gases,” <i>Communications in Mathematical Physics</i>, vol. 244, no. 2. Springer, pp. 347–393, 2004.","ista":"Lieb É, Seiringer R, Yngvason J. 2004. One-dimensional behavior of dilute, trapped Bose gases. Communications in Mathematical Physics. 244(2), 347–393.","chicago":"Lieb, Élliott, Robert Seiringer, and Jakob Yngvason. “One-Dimensional Behavior of Dilute, Trapped Bose Gases.” <i>Communications in Mathematical Physics</i>. Springer, 2004. <a href=\"https://doi.org/10.1007/s00220-003-0993-3\">https://doi.org/10.1007/s00220-003-0993-3</a>.","mla":"Lieb, Élliott, et al. “One-Dimensional Behavior of Dilute, Trapped Bose Gases.” <i>Communications in Mathematical Physics</i>, vol. 244, no. 2, Springer, 2004, pp. 347–93, doi:<a href=\"https://doi.org/10.1007/s00220-003-0993-3\">10.1007/s00220-003-0993-3</a>.","apa":"Lieb, É., Seiringer, R., &#38; Yngvason, J. (2004). One-dimensional behavior of dilute, trapped Bose gases. <i>Communications in Mathematical Physics</i>. Springer. <a href=\"https://doi.org/10.1007/s00220-003-0993-3\">https://doi.org/10.1007/s00220-003-0993-3</a>"},"_id":"2356","author":[{"first_name":"Élliott","full_name":"Lieb, Élliott H","last_name":"Lieb"},{"full_name":"Robert Seiringer","last_name":"Seiringer","orcid":"0000-0002-6781-0521","first_name":"Robert","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Jakob","last_name":"Yngvason","full_name":"Yngvason, Jakob"}],"oa":1,"date_created":"2018-12-11T11:57:11Z"},{"abstract":[{"lang":"eng","text":"An optical lattice model developed that is similar to the Bose-Hubbard model to describe the transition between Bose-Einstein condensation (BEC) and a Mott insulator state was analyzed. It was found that the system was a hard core lattice gas at half of the maximum density and the optical lattice was modeled by a periodic potential of strength λ. It was also observed that the interparticle interaction was essential for this transition that occurred even in the ground state. The results show that all the essential features could be proved rigorously such as the existence of BEC for small λ and its suppression for a large λ."}],"volume":70,"month":"08","quality_controlled":0,"publist_id":"4567","status":"public","publication_status":"published","author":[{"first_name":"Michael","last_name":"Aizenman","full_name":"Aizenman, Michael"},{"last_name":"Lieb","full_name":"Lieb, Élliott H","first_name":"Élliott"},{"orcid":"0000-0002-6781-0521","last_name":"Seiringer","full_name":"Robert Seiringer","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","first_name":"Robert"},{"first_name":"Jan","full_name":"Solovej, Jan P","last_name":"Solovej"},{"full_name":"Yngvason, Jakob","last_name":"Yngvason","first_name":"Jakob"}],"_id":"2360","extern":1,"publisher":"American Physical Society","citation":{"short":"M. Aizenman, É. Lieb, R. Seiringer, J. Solovej, J. Yngvason, Physical Review A - Atomic, Molecular, and Optical Physics 70 (2004) 023612-1-0236121-2.","ama":"Aizenman M, Lieb É, Seiringer R, Solovej J, Yngvason J. Bose-Einstein quantum phase transition in an optical lattice model. <i>Physical Review A - Atomic, Molecular, and Optical Physics</i>. 2004;70(2):023612-1-0236121-2. doi:<a href=\"https://doi.org/10.1103/PhysRevA.70.023612\">10.1103/PhysRevA.70.023612</a>","ista":"Aizenman M, Lieb É, Seiringer R, Solovej J, Yngvason J. 2004. Bose-Einstein quantum phase transition in an optical lattice model. Physical Review A - Atomic, Molecular, and Optical Physics. 70(2), 023612-1-0236121-2.","ieee":"M. Aizenman, É. Lieb, R. Seiringer, J. Solovej, and J. Yngvason, “Bose-Einstein quantum phase transition in an optical lattice model,” <i>Physical Review A - Atomic, Molecular, and Optical Physics</i>, vol. 70, no. 2. American Physical Society, pp. 023612-1-0236121-2, 2004.","chicago":"Aizenman, Michael, Élliott Lieb, Robert Seiringer, Jan Solovej, and Jakob Yngvason. “Bose-Einstein Quantum Phase Transition in an Optical Lattice Model.” <i>Physical Review A - Atomic, Molecular, and Optical Physics</i>. American Physical Society, 2004. <a href=\"https://doi.org/10.1103/PhysRevA.70.023612\">https://doi.org/10.1103/PhysRevA.70.023612</a>.","mla":"Aizenman, Michael, et al. “Bose-Einstein Quantum Phase Transition in an Optical Lattice Model.” <i>Physical Review A - Atomic, Molecular, and Optical Physics</i>, vol. 70, no. 2, American Physical Society, 2004, pp. 023612-1-0236121-2, doi:<a href=\"https://doi.org/10.1103/PhysRevA.70.023612\">10.1103/PhysRevA.70.023612</a>.","apa":"Aizenman, M., Lieb, É., Seiringer, R., Solovej, J., &#38; Yngvason, J. (2004). Bose-Einstein quantum phase transition in an optical lattice model. <i>Physical Review A - Atomic, Molecular, and Optical Physics</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevA.70.023612\">https://doi.org/10.1103/PhysRevA.70.023612</a>"},"date_created":"2018-12-11T11:57:12Z","oa":1,"date_published":"2004-08-01T00:00:00Z","publication":"Physical Review A - Atomic, Molecular, and Optical Physics","type":"journal_article","main_file_link":[{"open_access":"1","url":"http://arxiv.org/abs/cond-mat/0403240"}],"doi":"10.1103/PhysRevA.70.023612","date_updated":"2021-01-12T06:57:01Z","page":"023612 - 1-0236121-2","title":"Bose-Einstein quantum phase transition in an optical lattice model","issue":"2","day":"01","year":"2004","intvolume":"        70"},{"date_created":"2018-12-11T11:57:32Z","citation":{"chicago":"Lovász, László, Katalin Vesztergombi, Uli Wagner, and Emo Welzl. “Convex Quadrilaterals and K-Sets .” In <i>Towards a Theory of Geometric Graphs</i>, edited by János Pach, 342:139–48. American Mathematical Society, 2004. <a href=\"https://doi.org/10.1090/conm/342\">https://doi.org/10.1090/conm/342</a>.","mla":"Lovász, László, et al. “Convex Quadrilaterals and K-Sets .” <i>Towards a Theory of Geometric Graphs</i>, edited by János Pach, vol. 342, American Mathematical Society, 2004, pp. 139–48, doi:<a href=\"https://doi.org/10.1090/conm/342\">10.1090/conm/342</a>.","apa":"Lovász, L., Vesztergombi, K., Wagner, U., &#38; Welzl, E. (2004). Convex quadrilaterals and k-sets . In J. Pach (Ed.), <i>Towards a Theory of Geometric Graphs</i> (Vol. 342, pp. 139–148). American Mathematical Society. <a href=\"https://doi.org/10.1090/conm/342\">https://doi.org/10.1090/conm/342</a>","ieee":"L. Lovász, K. Vesztergombi, U. Wagner, and E. Welzl, “Convex quadrilaterals and k-sets ,” in <i>Towards a Theory of Geometric Graphs</i>, vol. 342, J. Pach, Ed. American Mathematical Society, 2004, pp. 139–148.","ista":"Lovász L, Vesztergombi K, Wagner U, Welzl E. 2004.Convex quadrilaterals and k-sets . In: Towards a Theory of Geometric Graphs. Contemporary Mathematics , vol. 342, 139–148.","short":"L. Lovász, K. Vesztergombi, U. Wagner, E. Welzl, in:, J. Pach (Ed.), Towards a Theory of Geometric Graphs, American Mathematical Society, 2004, pp. 139–148.","ama":"Lovász L, Vesztergombi K, Wagner U, Welzl E. Convex quadrilaterals and k-sets . In: Pach J, ed. <i>Towards a Theory of Geometric Graphs</i>. Vol 342. American Mathematical Society; 2004:139-148. doi:<a href=\"https://doi.org/10.1090/conm/342\">10.1090/conm/342</a>"},"publisher":"American Mathematical Society","alternative_title":["Contemporary Mathematics "],"extern":1,"_id":"2417","author":[{"first_name":"László","last_name":"Lovász","full_name":"Lovász, László"},{"last_name":"Vesztergombi","full_name":"Vesztergombi, Katalin","first_name":"Katalin"},{"orcid":"0000-0002-1494-0568","last_name":"Wagner","full_name":"Uli Wagner","first_name":"Uli","id":"36690CA2-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Welzl","full_name":"Welzl, Emo","first_name":"Emo"}],"publication_status":"published","status":"public","publist_id":"4508","quality_controlled":0,"month":"01","volume":342,"intvolume":"       342","year":"2004","day":"01","title":"Convex quadrilaterals and k-sets ","page":"139 - 148","date_updated":"2021-01-12T06:57:21Z","editor":[{"last_name":"Pach","full_name":"Pach, János","first_name":"János"}],"doi":"10.1090/conm/342","type":"book_chapter","publication":"Towards a Theory of Geometric Graphs","date_published":"2004-01-01T00:00:00Z"},{"date_created":"2018-12-11T11:57:35Z","extern":1,"publisher":"Springer","citation":{"ama":"Matoušek J, Wagner U. New constructions of weak ε-nets. <i>Discrete &#38; Computational Geometry</i>. 2004;32(2):195-206. doi:<a href=\"https://doi.org/10.1007/s00454-004-1116-4\">10.1007/s00454-004-1116-4</a>","short":"J. Matoušek, U. Wagner, Discrete &#38; Computational Geometry 32 (2004) 195–206.","apa":"Matoušek, J., &#38; Wagner, U. (2004). New constructions of weak ε-nets. <i>Discrete &#38; Computational Geometry</i>. Springer. <a href=\"https://doi.org/10.1007/s00454-004-1116-4\">https://doi.org/10.1007/s00454-004-1116-4</a>","mla":"Matoušek, Jiří, and Uli Wagner. “New Constructions of Weak ε-Nets.” <i>Discrete &#38; Computational Geometry</i>, vol. 32, no. 2, Springer, 2004, pp. 195–206, doi:<a href=\"https://doi.org/10.1007/s00454-004-1116-4\">10.1007/s00454-004-1116-4</a>.","chicago":"Matoušek, Jiří, and Uli Wagner. “New Constructions of Weak ε-Nets.” <i>Discrete &#38; Computational Geometry</i>. Springer, 2004. <a href=\"https://doi.org/10.1007/s00454-004-1116-4\">https://doi.org/10.1007/s00454-004-1116-4</a>.","ieee":"J. Matoušek and U. Wagner, “New constructions of weak ε-nets,” <i>Discrete &#38; Computational Geometry</i>, vol. 32, no. 2. Springer, pp. 195–206, 2004.","ista":"Matoušek J, Wagner U. 2004. New constructions of weak ε-nets. Discrete &#38; Computational Geometry. 32(2), 195–206."},"_id":"2425","author":[{"first_name":"Jiří","full_name":"Matoušek, Jiří","last_name":"Matoušek"},{"id":"36690CA2-F248-11E8-B48F-1D18A9856A87","first_name":"Uli","orcid":"0000-0002-1494-0568","last_name":"Wagner","full_name":"Uli Wagner"}],"status":"public","publication_status":"published","publist_id":"4500","quality_controlled":0,"volume":32,"abstract":[{"lang":"eng","text":"A finite set N ⊂ Rd is a weak ε-net for an n-point set X ⊂ Rd (with respect to convex sets) if N intersects every convex set K with |K ∩ X| ≥ εn. We give an alternative, and arguably simpler, proof of the fact, first shown by Chazelle et al., that every point set X in Rd admits a weak ε-net of cardinality O(ε-dpolylog(1/ε)). Moreover, for a number of special point sets (e.g., for points on the moment curve), our method gives substantially better bounds. The construction yields an algorithm to construct such weak ε-nets in time O(n ln(1/ε))."}],"month":"07","day":"01","year":"2004","intvolume":"        32","issue":"2","title":"New constructions of weak ε-nets","page":"195 - 206","doi":"10.1007/s00454-004-1116-4","date_updated":"2021-01-12T06:57:24Z","type":"journal_article","publication":"Discrete & Computational Geometry","date_published":"2004-07-01T00:00:00Z"},{"title":"Shape dimension and intrinsic metric from samples of manifolds","issue":"2","intvolume":"        32","year":"2004","day":"01","date_published":"2004-09-01T00:00:00Z","publication":"Discrete & Computational Geometry","type":"journal_article","date_updated":"2021-01-12T06:57:25Z","doi":"10.1007/s00454-004-1120-8","page":"245 - 267","author":[{"first_name":"Joachim","last_name":"Giesen","full_name":"Giesen, Joachim"},{"first_name":"Uli","id":"36690CA2-F248-11E8-B48F-1D18A9856A87","last_name":"Wagner","orcid":"0000-0002-1494-0568","full_name":"Uli Wagner"}],"_id":"2426","citation":{"ista":"Giesen J, Wagner U. 2004. Shape dimension and intrinsic metric from samples of manifolds. Discrete &#38; Computational Geometry. 32(2), 245–267.","ieee":"J. Giesen and U. Wagner, “Shape dimension and intrinsic metric from samples of manifolds,” <i>Discrete &#38; Computational Geometry</i>, vol. 32, no. 2. Springer, pp. 245–267, 2004.","apa":"Giesen, J., &#38; Wagner, U. (2004). Shape dimension and intrinsic metric from samples of manifolds. <i>Discrete &#38; Computational Geometry</i>. Springer. <a href=\"https://doi.org/10.1007/s00454-004-1120-8\">https://doi.org/10.1007/s00454-004-1120-8</a>","mla":"Giesen, Joachim, and Uli Wagner. “Shape Dimension and Intrinsic Metric from Samples of Manifolds.” <i>Discrete &#38; Computational Geometry</i>, vol. 32, no. 2, Springer, 2004, pp. 245–67, doi:<a href=\"https://doi.org/10.1007/s00454-004-1120-8\">10.1007/s00454-004-1120-8</a>.","chicago":"Giesen, Joachim, and Uli Wagner. “Shape Dimension and Intrinsic Metric from Samples of Manifolds.” <i>Discrete &#38; Computational Geometry</i>. Springer, 2004. <a href=\"https://doi.org/10.1007/s00454-004-1120-8\">https://doi.org/10.1007/s00454-004-1120-8</a>.","ama":"Giesen J, Wagner U. Shape dimension and intrinsic metric from samples of manifolds. <i>Discrete &#38; Computational Geometry</i>. 2004;32(2):245-267. doi:<a href=\"https://doi.org/10.1007/s00454-004-1120-8\">10.1007/s00454-004-1120-8</a>","short":"J. Giesen, U. Wagner, Discrete &#38; Computational Geometry 32 (2004) 245–267."},"publisher":"Springer","extern":1,"date_created":"2018-12-11T11:57:35Z","volume":32,"month":"09","abstract":[{"text":"We introduce the adaptive neighborhood graph as a data structure for modeling a smooth manifold M embedded in some Euclidean space ℝ d. We assume that M is known to us only through a finite sample P ⊂ M, as is often the case in applications. The adaptive neighborhood graph is a geometric graph on P. Its complexity is at most min{2O(k)n, n2}, where n = P and k = dim M, as opposed to the n[d/2] complexity of the Delaunay triangulation, which is often used to model manifolds. We prove that we can correctly infer the connected components and the dimension of M from the adaptive neighborhood graph provided a certain standard sampling condition is fulfilled. The running time of the dimension detection algorithm is d20(k7 log k) for each connected component of M. If the dimension is considered constant, this is a constant-time operation, and the adaptive neighborhood graph is of linear size. Moreover, the exponential dependence of the constants is only on the intrinsic dimension k, not on the ambient dimension d. This is of particular interest if the co-dimension is high, i.e., if k is much smaller than d, as is the case in many applications. The adaptive neighborhood graph also allows us to approximate the geodesic distances between the points in P.","lang":"eng"}],"quality_controlled":0,"publist_id":"4499","status":"public","publication_status":"published"},{"page":"5774 - 5775","doi":"10.1242/dev.01463","date_updated":"2021-01-12T06:57:37Z","type":"review","date_published":"2004-12-01T00:00:00Z","publication":"Development","language":[{"iso":"eng"}],"day":"01","year":"2004","intvolume":"       131","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","issue":"23","title":"The Matryoshka dolls of plant polarity","publication_status":"published","status":"public","publist_id":"4442","quality_controlled":"1","volume":131,"month":"12","date_created":"2018-12-11T11:57:48Z","extern":"1","publisher":"Company of Biologists","citation":{"ama":"Sauer M, Friml J. The Matryoshka dolls of plant polarity. <i>Development</i>. 2004;131(23):5774-5775. doi:<a href=\"https://doi.org/10.1242/dev.01463\">10.1242/dev.01463</a>","short":"M. Sauer, J. Friml, Development 131 (2004) 5774–5775.","mla":"Sauer, Michael, and Jiří Friml. “The Matryoshka Dolls of Plant Polarity.” <i>Development</i>, vol. 131, no. 23, Company of Biologists, 2004, pp. 5774–75, doi:<a href=\"https://doi.org/10.1242/dev.01463\">10.1242/dev.01463</a>.","apa":"Sauer, M., &#38; Friml, J. (2004). The Matryoshka dolls of plant polarity. <i>Development</i>. Company of Biologists. <a href=\"https://doi.org/10.1242/dev.01463\">https://doi.org/10.1242/dev.01463</a>","chicago":"Sauer, Michael, and Jiří Friml. “The Matryoshka Dolls of Plant Polarity.” <i>Development</i>. Company of Biologists, 2004. <a href=\"https://doi.org/10.1242/dev.01463\">https://doi.org/10.1242/dev.01463</a>.","ista":"Sauer M, Friml J. 2004. The Matryoshka dolls of plant polarity. Development. 131(23), 5774–5775.","ieee":"M. Sauer and J. Friml, “The Matryoshka dolls of plant polarity,” <i>Development</i>, vol. 131, no. 23. Company of Biologists, pp. 5774–5775, 2004."},"author":[{"last_name":"Sauer","full_name":"Sauer, Michael","first_name":"Michael"},{"first_name":"Jirí","id":"4159519E-F248-11E8-B48F-1D18A9856A87","full_name":"Friml, Jirí","orcid":"0000-0002-8302-7596","last_name":"Friml"}],"_id":"2461","oa_version":"None"},{"intvolume":"        49","year":"2004","day":"01","issue":"3 Suppl","title":"Function and distribution of glutamate receptors in the central synapses","page":"287 - 294","date_updated":"2020-07-14T12:45:44Z","type":"review","publication":"Tanpakushitsu kakusan koso Protein nucleic acid enzyme","date_published":"2004-02-01T00:00:00Z","date_created":"2018-12-11T11:58:48Z","citation":{"ama":"Momiyama A, Shigemoto R. Function and distribution of glutamate receptors in the central synapses. <i>Tanpakushitsu kakusan koso Protein nucleic acid enzyme</i>. 2004;49(3 Suppl):287-294.","short":"A. Momiyama, R. Shigemoto, Tanpakushitsu Kakusan Koso Protein Nucleic Acid Enzyme 49 (2004) 287–294.","mla":"Momiyama, Akiko, and Ryuichi Shigemoto. “Function and Distribution of Glutamate Receptors in the Central Synapses.” <i>Tanpakushitsu Kakusan Koso Protein Nucleic Acid Enzyme</i>, vol. 49, no. 3 Suppl, Kyoritsu Shuppan, 2004, pp. 287–94.","apa":"Momiyama, A., &#38; Shigemoto, R. (2004). Function and distribution of glutamate receptors in the central synapses. <i>Tanpakushitsu Kakusan Koso Protein Nucleic Acid Enzyme</i>. Kyoritsu Shuppan.","chicago":"Momiyama, Akiko, and Ryuichi Shigemoto. “Function and Distribution of Glutamate Receptors in the Central Synapses.” <i>Tanpakushitsu Kakusan Koso Protein Nucleic Acid Enzyme</i>. Kyoritsu Shuppan, 2004.","ista":"Momiyama A, Shigemoto R. 2004. Function and distribution of glutamate receptors in the central synapses. Tanpakushitsu kakusan koso Protein nucleic acid enzyme. 49(3 Suppl), 287–294.","ieee":"A. Momiyama and R. Shigemoto, “Function and distribution of glutamate receptors in the central synapses,” <i>Tanpakushitsu kakusan koso Protein nucleic acid enzyme</i>, vol. 49, no. 3 Suppl. Kyoritsu Shuppan, pp. 287–294, 2004."},"publisher":"Kyoritsu Shuppan","extern":1,"_id":"2636","author":[{"full_name":"Momiyama, Akiko","last_name":"Momiyama","first_name":"Akiko"},{"orcid":"0000-0001-8761-9444","last_name":"Shigemoto","full_name":"Ryuichi Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi"}],"publication_status":"published","status":"public","publist_id":"4261","quality_controlled":0,"month":"02","volume":49},{"date_created":"2018-12-11T11:58:48Z","_id":"2638","author":[{"first_name":"Ákos","full_name":"Kulik, Ákos","last_name":"Kulik"},{"first_name":"Kazuhiko","full_name":"Nakadate, Kazuhiko","last_name":"Nakadate"},{"last_name":"Hagiwara","full_name":"Hagiwara, Akari","first_name":"Akari"},{"last_name":"Fukazawa","full_name":"Fukazawa, Yugo","first_name":"Yugo"},{"last_name":"Luján","full_name":"Luján, Rafael","first_name":"Rafael"},{"first_name":"Hiromitsu","last_name":"Saito","full_name":"Saito, Hiromitsu"},{"last_name":"Suzuki","full_name":"Suzuki, Noboru","first_name":"Noboru"},{"full_name":"Futatsugi, Akira","last_name":"Futatsugi","first_name":"Akira"},{"full_name":"Mikoshiba, Katsuhiko","last_name":"Mikoshiba","first_name":"Katsuhiko"},{"full_name":"Frotscher, Michael","last_name":"Frotscher","first_name":"Michael"},{"full_name":"Ryuichi Shigemoto","last_name":"Shigemoto","orcid":"0000-0001-8761-9444","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"}],"citation":{"short":"Á. Kulik, K. Nakadate, A. Hagiwara, Y. Fukazawa, R. Luján, H. Saito, N. Suzuki, A. Futatsugi, K. Mikoshiba, M. Frotscher, R. Shigemoto, European Journal of Neuroscience 19 (2004) 2169–2178.","ama":"Kulik Á, Nakadate K, Hagiwara A, et al. Immunocytochemical localization of the α1A subunit of the P/Q-type calcium channel in the rat cerebellum. <i>European Journal of Neuroscience</i>. 2004;19(8):2169-2178. doi:<a href=\"https://doi.org/10.1111/j.0953-816X.2004.03319.x\">10.1111/j.0953-816X.2004.03319.x</a>","ista":"Kulik Á, Nakadate K, Hagiwara A, Fukazawa Y, Luján R, Saito H, Suzuki N, Futatsugi A, Mikoshiba K, Frotscher M, Shigemoto R. 2004. Immunocytochemical localization of the α1A subunit of the P/Q-type calcium channel in the rat cerebellum. European Journal of Neuroscience. 19(8), 2169–2178.","ieee":"Á. Kulik <i>et al.</i>, “Immunocytochemical localization of the α1A subunit of the P/Q-type calcium channel in the rat cerebellum,” <i>European Journal of Neuroscience</i>, vol. 19, no. 8. Wiley-Blackwell, pp. 2169–2178, 2004.","chicago":"Kulik, Ákos, Kazuhiko Nakadate, Akari Hagiwara, Yugo Fukazawa, Rafael Luján, Hiromitsu Saito, Noboru Suzuki, et al. “Immunocytochemical Localization of the Α1A Subunit of the P/Q-Type Calcium Channel in the Rat Cerebellum.” <i>European Journal of Neuroscience</i>. Wiley-Blackwell, 2004. <a href=\"https://doi.org/10.1111/j.0953-816X.2004.03319.x\">https://doi.org/10.1111/j.0953-816X.2004.03319.x</a>.","mla":"Kulik, Ákos, et al. “Immunocytochemical Localization of the Α1A Subunit of the P/Q-Type Calcium Channel in the Rat Cerebellum.” <i>European Journal of Neuroscience</i>, vol. 19, no. 8, Wiley-Blackwell, 2004, pp. 2169–78, doi:<a href=\"https://doi.org/10.1111/j.0953-816X.2004.03319.x\">10.1111/j.0953-816X.2004.03319.x</a>.","apa":"Kulik, Á., Nakadate, K., Hagiwara, A., Fukazawa, Y., Luján, R., Saito, H., … Shigemoto, R. (2004). Immunocytochemical localization of the α1A subunit of the P/Q-type calcium channel in the rat cerebellum. <i>European Journal of Neuroscience</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1111/j.0953-816X.2004.03319.x\">https://doi.org/10.1111/j.0953-816X.2004.03319.x</a>"},"publisher":"Wiley-Blackwell","extern":1,"publist_id":"4259","publication_status":"published","status":"public","month":"04","volume":19,"abstract":[{"text":"Among various types of low- and high-threshold calcium channels, the high voltage-activated P/Q-type channel is the most abundant in the cerebellum. These P/Q-type channels are involved in the regulation of neurotransmitter release and in the integration of dendritic inputs. We used an antibody specific for the α1A subunit of the P/Q-type channel in quantitative pre-embedding immunogold labelling combined with three-dimensional reconstruction to reveal the subcellular distribution of pre- and postsynaptic P/Q-type channels in the rat cerebellum. At the light microscopic level, immunoreactivity for the α1A protein was prevalent in the molecular layer, whereas immunostaining was moderate in the somata of Purkinje cells and weak in the granule cell layer. At the electron microscopic level, the most intense Immunoreactivity for the α1A subunit was found in the presynaptic active zone of parallel fibre varicosities. The dendritic spines of Purkinje cells were also strongly labelled with the highest density of immunoparticles detected within 180 nm from the edge of the asymmetrical parallel fibre-Purkinje cell synapses. By contrast, the immunolabelling was sparse in climbing fibre varicosities and axon terminals of GABAergic cells, and weak and diffuse in dendritic shafts of Purkinje cells. The association of the α1A subunit with the glutamatergic parallel fibre-Purkinje cell synapses suggests that presynaptic channels have a major role in the mediation of excitatory neurotransmission, whereas postsynaptic channels are likely to be involved in depolarization-induced generation of local calcium transients in Purkinje cells.","lang":"eng"}],"quality_controlled":0,"issue":"8","intvolume":"        19","day":"01","year":"2004","title":"Immunocytochemical localization of the α1A subunit of the P/Q-type calcium channel in the rat cerebellum","date_updated":"2021-01-12T06:58:44Z","doi":"10.1111/j.0953-816X.2004.03319.x","page":"2169 - 2178","date_published":"2004-04-01T00:00:00Z","publication":"European Journal of Neuroscience","type":"journal_article"},{"page":"552 - 569","doi":"10.1111/j.0953-816X.2003.03091.x","date_updated":"2021-01-12T06:58:44Z","type":"journal_article","date_published":"2004-02-01T00:00:00Z","publication":"European Journal of Neuroscience","year":"2004","day":"01","intvolume":"        19","issue":"3","title":"GABAergic basket cells expressing cholecystokinin contain vesicular glutamate transporter type 3 (VGLUT3) in their synaptic terminals in hippocampus and isocortex of the rat","publication_status":"published","status":"public","publist_id":"4260","quality_controlled":0,"volume":19,"month":"02","abstract":[{"lang":"eng","text":"Vesicular glutamate transporter type 3 (VGLUT3) containing neuronal elements were characterized using antibodies to VGLUT3 and molecular cell markers. All VGLUT3-positive somata were immunoreactive for CCK, and very rarely, also for calbindin; none was positive for parvalbumin, calretinin, VIP or somatostatin. In the CA1 area, 26.8 ± 0.7% of CCK-positive interneuron somata were VGLUT3-positive, a nonoverlapping 22.8 ± 1.9% were calbindin-positive, 10.7 ± 2.5% VIP-positive and the rest were only CCK-positive. The patterns of coexpression were similar in the CA3 area, the dentate gyrus and the isocortex. Immunoreactivity for VGLUT3 was undetectable in pyramidal and dentate granule cells. Boutons colabelled for VGLUT3, CCK and GAD were most abundant in the cellular layers of the hippocampus and in layers II-III of the isocortex. Large VGLUT3-labelled boutons at the border of strata radiatum and lacunosum-moleculare in the CA1 area were negative for GAD, but were labelled for vesicular monoamine transporter type 2, plasmalemmal serotonin transporter or serotonin. No colocalization was found in terminals between VGLUT3 and parvalbumin, vesicular acetylcholine transporter and group III (mGluR7a,b; mGluR8a,b) metabotropic glutamate receptors. In stratum radiatum and the isocortex, VGLUT3-positive but GAD-negative boutons heavily innervated the soma and proximal dendrites of some VGLUT3- or calbindin-positive interneurons. The results suggest that boutons coexpressing VGLUT3, CCK and GAD originate from CCK-positive basket cells, which are VIP-immunonegative. Other VGLUT3-positive boutons immunopositive for serotonergic markers but negative for GAD probably originate from the median raphe nucleus and innervate select interneurons. The presumed amino acid substrate of VGLUT3 may act on presynaptic kainate or group II metabotropic glutamate receptors."}],"date_created":"2018-12-11T11:58:49Z","extern":1,"publisher":"Wiley-Blackwell","citation":{"ista":"Somogyi J, Baude A, Omori Y, Shimizu H, El Mestikawy S, Fukaya M, Shigemoto R, Watanabe M, Somogyi P. 2004. GABAergic basket cells expressing cholecystokinin contain vesicular glutamate transporter type 3 (VGLUT3) in their synaptic terminals in hippocampus and isocortex of the rat. European Journal of Neuroscience. 19(3), 552–569.","ieee":"J. Somogyi <i>et al.</i>, “GABAergic basket cells expressing cholecystokinin contain vesicular glutamate transporter type 3 (VGLUT3) in their synaptic terminals in hippocampus and isocortex of the rat,” <i>European Journal of Neuroscience</i>, vol. 19, no. 3. Wiley-Blackwell, pp. 552–569, 2004.","apa":"Somogyi, J., Baude, A., Omori, Y., Shimizu, H., El Mestikawy, S., Fukaya, M., … Somogyi, P. (2004). GABAergic basket cells expressing cholecystokinin contain vesicular glutamate transporter type 3 (VGLUT3) in their synaptic terminals in hippocampus and isocortex of the rat. <i>European Journal of Neuroscience</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1111/j.0953-816X.2003.03091.x\">https://doi.org/10.1111/j.0953-816X.2003.03091.x</a>","mla":"Somogyi, Jozsef, et al. “GABAergic Basket Cells Expressing Cholecystokinin Contain Vesicular Glutamate Transporter Type 3 (VGLUT3) in Their Synaptic Terminals in Hippocampus and Isocortex of the Rat.” <i>European Journal of Neuroscience</i>, vol. 19, no. 3, Wiley-Blackwell, 2004, pp. 552–69, doi:<a href=\"https://doi.org/10.1111/j.0953-816X.2003.03091.x\">10.1111/j.0953-816X.2003.03091.x</a>.","chicago":"Somogyi, Jozsef, Agnès Baude, Yuko Omori, Hidemi Shimizu, Salah El Mestikawy, Masahiro Fukaya, Ryuichi Shigemoto, Masahiko Watanabe, and Péter Somogyi. “GABAergic Basket Cells Expressing Cholecystokinin Contain Vesicular Glutamate Transporter Type 3 (VGLUT3) in Their Synaptic Terminals in Hippocampus and Isocortex of the Rat.” <i>European Journal of Neuroscience</i>. Wiley-Blackwell, 2004. <a href=\"https://doi.org/10.1111/j.0953-816X.2003.03091.x\">https://doi.org/10.1111/j.0953-816X.2003.03091.x</a>.","ama":"Somogyi J, Baude A, Omori Y, et al. GABAergic basket cells expressing cholecystokinin contain vesicular glutamate transporter type 3 (VGLUT3) in their synaptic terminals in hippocampus and isocortex of the rat. <i>European Journal of Neuroscience</i>. 2004;19(3):552-569. doi:<a href=\"https://doi.org/10.1111/j.0953-816X.2003.03091.x\">10.1111/j.0953-816X.2003.03091.x</a>","short":"J. Somogyi, A. Baude, Y. Omori, H. Shimizu, S. El Mestikawy, M. Fukaya, R. Shigemoto, M. Watanabe, P. Somogyi, European Journal of Neuroscience 19 (2004) 552–569."},"_id":"2639","author":[{"first_name":"Jozsef","full_name":"Somogyi, Jozsef","last_name":"Somogyi"},{"first_name":"Agnès","full_name":"Baude, Agnès","last_name":"Baude"},{"first_name":"Yuko","last_name":"Omori","full_name":"Omori, Yuko"},{"first_name":"Hidemi","full_name":"Shimizu, Hidemi","last_name":"Shimizu"},{"last_name":"El Mestikawy","full_name":"El-Mestikawy, Salah","first_name":"Salah"},{"full_name":"Fukaya, Masahiro","last_name":"Fukaya","first_name":"Masahiro"},{"first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Ryuichi Shigemoto","last_name":"Shigemoto","orcid":"0000-0001-8761-9444"},{"first_name":"Masahiko","full_name":"Watanabe, Masahiko","last_name":"Watanabe"},{"last_name":"Somogyi","full_name":"Somogyi, Péter","first_name":"Péter"}]},{"title":"Immunohistochemical localization of Ih channel subunits, HCN1-4, in the rat brain","intvolume":"       471","day":"05","year":"2004","issue":"3","type":"journal_article","publication":"Journal of Comparative Neurology","date_published":"2004-04-05T00:00:00Z","page":"241 - 276","date_updated":"2021-01-12T06:58:45Z","doi":"10.1002/cne.11039","citation":{"ama":"Notomi T, Shigemoto R. Immunohistochemical localization of Ih channel subunits, HCN1-4, in the rat brain. <i>Journal of Comparative Neurology</i>. 2004;471(3):241-276. doi:<a href=\"https://doi.org/10.1002/cne.11039\">10.1002/cne.11039</a>","short":"T. Notomi, R. Shigemoto, Journal of Comparative Neurology 471 (2004) 241–276.","mla":"Notomi, Takuya, and Ryuichi Shigemoto. “Immunohistochemical Localization of Ih Channel Subunits, HCN1-4, in the Rat Brain.” <i>Journal of Comparative Neurology</i>, vol. 471, no. 3, Wiley-Blackwell, 2004, pp. 241–76, doi:<a href=\"https://doi.org/10.1002/cne.11039\">10.1002/cne.11039</a>.","apa":"Notomi, T., &#38; Shigemoto, R. (2004). Immunohistochemical localization of Ih channel subunits, HCN1-4, in the rat brain. <i>Journal of Comparative Neurology</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1002/cne.11039\">https://doi.org/10.1002/cne.11039</a>","chicago":"Notomi, Takuya, and Ryuichi Shigemoto. “Immunohistochemical Localization of Ih Channel Subunits, HCN1-4, in the Rat Brain.” <i>Journal of Comparative Neurology</i>. Wiley-Blackwell, 2004. <a href=\"https://doi.org/10.1002/cne.11039\">https://doi.org/10.1002/cne.11039</a>.","ista":"Notomi T, Shigemoto R. 2004. Immunohistochemical localization of Ih channel subunits, HCN1-4, in the rat brain. Journal of Comparative Neurology. 471(3), 241–276.","ieee":"T. Notomi and R. Shigemoto, “Immunohistochemical localization of Ih channel subunits, HCN1-4, in the rat brain,” <i>Journal of Comparative Neurology</i>, vol. 471, no. 3. Wiley-Blackwell, pp. 241–276, 2004."},"extern":1,"publisher":"Wiley-Blackwell","_id":"2640","author":[{"last_name":"Notomi","full_name":"Notomi, Takuya","first_name":"Takuya"},{"last_name":"Shigemoto","orcid":"0000-0001-8761-9444","full_name":"Ryuichi Shigemoto","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"}],"date_created":"2018-12-11T11:58:49Z","quality_controlled":0,"volume":471,"abstract":[{"lang":"eng","text":"Hyperpolarization-activated cation currents (Ih) contribute to various physiological properties and functions in the brain, including neuronal pacemaker activity, setting of resting membrane potential, and dendritic integration of synaptic input. Four subunits of the Hyperpolarization-activated and Cyclic-Nucleotide-gated nonselective cation channels (HCN1-4), which generate Ih, have been cloned recently. To better understand the functional diversity of Ih in the brain, we examined precise immunohistochemical localization of four HCNs in the rat brain. Immunoreactivity for HCN1 showed predominantly cortical distribution, being intense in the neocortex, hippocampus, superior colliculus, and cerebellum, whereas those for HCN3 and HCN4 exhibited subcortical distribution mainly concentrated in the hypothalamus and thalamus, respectively. Immunoreactivity for HCN2 had a widespread distribution throughout the brain. Double immunofluorescence revealed colocalization of immunoreactivity for HCN1 and HCN2 in distal dendrites of pyramidal cells in the hippocampus and neocortex. At the electron microscopic level, immunogold particles for HCN1 and HCN2 had similar distribution patterns along plasma membrane of dendritic shafts in layer I of the neocortex and stratum lacunosum moleculare of the hippocampal CA1 area, suggesting that these subunits could form heteromeric channels. Our results further indicate that HCNs are localized not only in somato-dendritic compartments but also in axonal compartments of neurons. Immunoreactivity for HCNs often occurred in preterminal rather than terminal portions of axons and in specific populations of myelinated axons. We also found HCN2-immunopositive oligodendrocytes including perineuronal oligodendrocytes throughout the brain. These results support previous electrophysiological findings and further suggest unexpected roles of Ih channels in the brain."}],"month":"04","status":"public","publication_status":"published","publist_id":"4258"},{"author":[{"full_name":"Kang, Youngnam","last_name":"Kang","first_name":"Youngnam"},{"first_name":"Takuya","last_name":"Notomi","full_name":"Notomi, Takuya"},{"last_name":"Saito","full_name":"Saito, Mitsuru","first_name":"Mitsuru"},{"full_name":"Zhang, Wei","last_name":"Zhang","first_name":"Wei"},{"last_name":"Shigemoto","orcid":"0000-0001-8761-9444","full_name":"Ryuichi Shigemoto","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"}],"_id":"2641","publisher":"Society for Neuroscience","extern":1,"citation":{"ieee":"Y. Kang, T. Notomi, M. Saito, W. Zhang, and R. Shigemoto, “Bidirectional interactions between H-channels and Na+-K + pumps in mesencephalic trigeminal neurons,” <i>Journal of Neuroscience</i>, vol. 24, no. 14. Society for Neuroscience, pp. 3694–3702, 2004.","ista":"Kang Y, Notomi T, Saito M, Zhang W, Shigemoto R. 2004. Bidirectional interactions between H-channels and Na+-K + pumps in mesencephalic trigeminal neurons. Journal of Neuroscience. 24(14), 3694–3702.","apa":"Kang, Y., Notomi, T., Saito, M., Zhang, W., &#38; Shigemoto, R. (2004). Bidirectional interactions between H-channels and Na+-K + pumps in mesencephalic trigeminal neurons. <i>Journal of Neuroscience</i>. Society for Neuroscience. <a href=\"https://doi.org/10.1523/JNEUROSCI.5641-03.2004\">https://doi.org/10.1523/JNEUROSCI.5641-03.2004</a>","mla":"Kang, Youngnam, et al. “Bidirectional Interactions between H-Channels and Na+-K + Pumps in Mesencephalic Trigeminal Neurons.” <i>Journal of Neuroscience</i>, vol. 24, no. 14, Society for Neuroscience, 2004, pp. 3694–702, doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.5641-03.2004\">10.1523/JNEUROSCI.5641-03.2004</a>.","chicago":"Kang, Youngnam, Takuya Notomi, Mitsuru Saito, Wei Zhang, and Ryuichi Shigemoto. “Bidirectional Interactions between H-Channels and Na+-K + Pumps in Mesencephalic Trigeminal Neurons.” <i>Journal of Neuroscience</i>. Society for Neuroscience, 2004. <a href=\"https://doi.org/10.1523/JNEUROSCI.5641-03.2004\">https://doi.org/10.1523/JNEUROSCI.5641-03.2004</a>.","ama":"Kang Y, Notomi T, Saito M, Zhang W, Shigemoto R. Bidirectional interactions between H-channels and Na+-K + pumps in mesencephalic trigeminal neurons. <i>Journal of Neuroscience</i>. 2004;24(14):3694-3702. doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.5641-03.2004\">10.1523/JNEUROSCI.5641-03.2004</a>","short":"Y. Kang, T. Notomi, M. Saito, W. Zhang, R. Shigemoto, Journal of Neuroscience 24 (2004) 3694–3702."},"date_created":"2018-12-11T11:58:49Z","volume":24,"abstract":[{"lang":"eng","text":"The Na+-K+ pump current (Ip) and the h-current (Ih) flowing through hyperpolarization-activated channels (h-channels) participate in generating the resting potential. These two currents are thought to be produced independently. We show here bidirectional interactions between Na+-K+ pumps and h-channels in mesencephalic trigeminal neurons. Activation of Ih leads to the generation of two types of ouabain-sensitive Ip with temporal profiles similar to those of instantaneous and slow components of I h, presumably reflecting Na+ transients in a restricted cellular space. Moreover, the Ip activated by instantaneous I h can facilitate the subsequent activation of slow Ih. Such counteractive and cooperative interactions were also disclosed by replacing extracellular Na+ with Li+, which is permeant through h-channels but does not stimulate the Na+-K+ pump as strongly as Na+ ions. These observations indicate that the interactions are bidirectional and mediated by Na+ ions. Also after substitution of extracellular Na+ with Li+, the tail Ih was reduced markedly despite an enhancement of Ih itself, attributable to a negative shift of the reversal potential for I h presumably caused by intracellular accumulation of Li+ ions. This suggests the presence of a microdomain where the interactions can take place. Thus, the bidirectional interactions between Na+-K + pumps and h-channels are likely to be mediated by Na+ microdomain. Consistent with these findings, hyperpolarization-activated and cyclic nucleotide-modulated subunits (HCN1/2) and the Na+-K + pump α3 isoform were colocalized in plasma membrane of mesencephalic trigeminal neurons having numerous spines."}],"month":"04","quality_controlled":0,"publist_id":"4257","publication_status":"published","status":"public","title":"Bidirectional interactions between H-channels and Na+-K + pumps in mesencephalic trigeminal neurons","issue":"14","day":"07","year":"2004","intvolume":"        24","publication":"Journal of Neuroscience","date_published":"2004-04-07T00:00:00Z","type":"journal_article","doi":"10.1523/JNEUROSCI.5641-03.2004","date_updated":"2021-01-12T06:58:45Z","page":"3694 - 3702"},{"quality_controlled":0,"volume":14,"abstract":[{"text":"In the hippocampal CA1 region, metabotropic glutamate subtype 1 (mGluR1) receptors have been implicated in a variety of physiological responses to glutamate, which include modulation of synaptic transmission and plasticity, as well as neuronal excitability and synchronization. The mGluR1α isoform is characteristically expressed only by nonprincipal cells, and it is particularly enriched in somatostatin (SS -containing interneurons in stratum oriens-alveus. Anatomical and physiological data have indicated the presence of mGluR1α in several distinct classes of interneurons with their somata located also in strata pyramidale, radiatum, and lacunosum moleculare. Each different interneuron subtype, as defined by functionally relevant criteria, including input/output characteristics and expression of selective molecular markers, subserves distinct functions in local hippocampal circuits. We have investigated which of the different CA1 interneuron classes express mGluR1α by immunofluorescent labeling, combining antibodies to mGluR1α, calcium-binding proteins, and neuropeptides, and by intracellular labeling in vitro. Several types of interneuron that are immunopositive for mGluR1α each targeted different domains of pyramidal cells and included (1) O-LM interneurons, found to coexpress both SS and parvalbumin (PV); (2) interneurons with target selectivity for other interneurons, expressing vasoactive intestinal polypeptide (VIP) and/or the calcium-binding protein calretinin; (3) procholecystokinin-immunopositive interneurons probably non-basket and dendrite-targeting; and (4) an as-yet unidentified SS-immunoreactive but PV-immunonegative interneuron class, possibly corresponding to oriensbistratified cells. Estimation of the relative proportion of mGluR1α-positive interneurons showed 43%, 46%, and 30% co-labeling with SS, VIP, or PV, respectively. The identification of the specific subclasses of CA1 interneurons expressing mGluR1α provides the network basis for assessing the contribution of this receptor to the excitability of the hippocampus.","lang":"eng"}],"month":"01","publication_status":"published","status":"public","publist_id":"4256","publisher":"Wiley-Blackwell","extern":1,"citation":{"ama":"Ferraguti F, Cobden P, Pollard M, et al. Immunolocalization of metabotropic glutamate receptor 1α (mGluR1α) in distinct classes of interneuron in the CA1 region of the rat hippocampus. <i>Hippocampus</i>. 2004;14(2):193-215. doi:<a href=\"https://doi.org/10.1002/hipo.10163\">10.1002/hipo.10163</a>","short":"F. Ferraguti, P. Cobden, M. Pollard, D. Cope, R. Shigemoto, M. Watanabe, P. Somogyi, Hippocampus 14 (2004) 193–215.","apa":"Ferraguti, F., Cobden, P., Pollard, M., Cope, D., Shigemoto, R., Watanabe, M., &#38; Somogyi, P. (2004). Immunolocalization of metabotropic glutamate receptor 1α (mGluR1α) in distinct classes of interneuron in the CA1 region of the rat hippocampus. <i>Hippocampus</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1002/hipo.10163\">https://doi.org/10.1002/hipo.10163</a>","mla":"Ferraguti, Francesco, et al. “Immunolocalization of Metabotropic Glutamate Receptor 1α (MGluR1α) in Distinct Classes of Interneuron in the CA1 Region of the Rat Hippocampus.” <i>Hippocampus</i>, vol. 14, no. 2, Wiley-Blackwell, 2004, pp. 193–215, doi:<a href=\"https://doi.org/10.1002/hipo.10163\">10.1002/hipo.10163</a>.","chicago":"Ferraguti, Francesco, Philip Cobden, Marie Pollard, David Cope, Ryuichi Shigemoto, Masahiko Watanabe, and Péter Somogyi. “Immunolocalization of Metabotropic Glutamate Receptor 1α (MGluR1α) in Distinct Classes of Interneuron in the CA1 Region of the Rat Hippocampus.” <i>Hippocampus</i>. Wiley-Blackwell, 2004. <a href=\"https://doi.org/10.1002/hipo.10163\">https://doi.org/10.1002/hipo.10163</a>.","ista":"Ferraguti F, Cobden P, Pollard M, Cope D, Shigemoto R, Watanabe M, Somogyi P. 2004. Immunolocalization of metabotropic glutamate receptor 1α (mGluR1α) in distinct classes of interneuron in the CA1 region of the rat hippocampus. Hippocampus. 14(2), 193–215.","ieee":"F. Ferraguti <i>et al.</i>, “Immunolocalization of metabotropic glutamate receptor 1α (mGluR1α) in distinct classes of interneuron in the CA1 region of the rat hippocampus,” <i>Hippocampus</i>, vol. 14, no. 2. Wiley-Blackwell, pp. 193–215, 2004."},"author":[{"first_name":"Francesco","last_name":"Ferraguti","full_name":"Ferraguti, Francesco"},{"full_name":"Cobden, Philip M","last_name":"Cobden","first_name":"Philip"},{"first_name":"Marie","last_name":"Pollard","full_name":"Pollard, Marie"},{"first_name":"David","full_name":"Cope, David W","last_name":"Cope"},{"first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8761-9444","last_name":"Shigemoto","full_name":"Ryuichi Shigemoto"},{"full_name":"Watanabe, Masahiko","last_name":"Watanabe","first_name":"Masahiko"},{"full_name":"Somogyi, Péter","last_name":"Somogyi","first_name":"Péter"}],"_id":"2642","date_created":"2018-12-11T11:58:50Z","type":"journal_article","publication":"Hippocampus","date_published":"2004-01-01T00:00:00Z","page":"193 - 215","doi":"10.1002/hipo.10163","date_updated":"2021-01-12T06:58:46Z","title":"Immunolocalization of metabotropic glutamate receptor 1α (mGluR1α) in distinct classes of interneuron in the CA1 region of the rat hippocampus","day":"01","year":"2004","intvolume":"        14","issue":"2"},{"status":"public","publication_status":"published","publist_id":"4254","quality_controlled":0,"volume":475,"month":"07","abstract":[{"lang":"eng","text":"Metabotropic γ-aminobutyric acid receptors (GABAB) are involved in pre- and postsynaptic inhibitory effects upon auditory neurons and have been implicated in different aspects of acoustic information processing. To understand better the mechanisms by which GABAB receptors mediate their inhibitory effects, we used pre-embedding immunocytochemical techniques combined with quantification of immunogold particles to reveal the precise subcellular distribution of the GABAB1 subunit in the rat dorsal cochlear nucleus. At the light microscopic level, GABAB1 was detected in all divisions of the cochlear complex. The most intense immunoreactivity for GABAB1 was found in the dorsal cochlear nucleus, whereas immunoreactivity in the anteroventral and posteroventral cochlear nuclei was very low. In the dorsal cochlear nucleus, a punctate labeling was observed in the superficial (molecular and fusiform cell) layers. At the electron microscopic level, GABAB1 was found at both post- and presynaptic locations. Postsynaptically, GABAB1 was localized mainly in the dendritic spines of presumed fusiform cells. Quantitative immunogold immunocytochemistry revealed that the highest concentration of GABA B1 in the plasma membrane was in dendritic spines, followed by dendritic shafts and somata. Thus, the most intense immunoreactivity for GABAB1 was observed in dendritic spines with a high density of immunogold particles at extrasynaptic sites, peaking around 300 nm from glutamatergic synapses. This is in contrast to GABAergic synapses, in which GABAB1 was only occasionally found. Presynaptically, receptor immunoreactivity was detected primarily in axospinous endings, probably from granule cells, in both the active zone and extrasynaptic sites. The localization of GABAB1 relative to synaptic sites in the DCN suggests a role for the receptor in the regulation of dendritic excitability and excitatory inputs."}],"date_created":"2018-12-11T11:58:50Z","extern":1,"publisher":"Wiley-Blackwell","citation":{"ista":"Luján R, Shigemoto R, Kulik Á, Juíz J. 2004. Localization of the GABAB receptor 1a/b subunit relative to glutamatergic synapses in the dorsal cochlear nucleus of the rat. Journal of Comparative Neurology. 475(1), 36–46.","ieee":"R. Luján, R. Shigemoto, Á. Kulik, and J. Juíz, “Localization of the GABAB receptor 1a/b subunit relative to glutamatergic synapses in the dorsal cochlear nucleus of the rat,” <i>Journal of Comparative Neurology</i>, vol. 475, no. 1. Wiley-Blackwell, pp. 36–46, 2004.","chicago":"Luján, Rafael, Ryuichi Shigemoto, Ákos Kulik, and José Juíz. “Localization of the GABAB Receptor 1a/b Subunit Relative to Glutamatergic Synapses in the Dorsal Cochlear Nucleus of the Rat.” <i>Journal of Comparative Neurology</i>. Wiley-Blackwell, 2004. <a href=\"https://doi.org/10.1002/cne.20160\">https://doi.org/10.1002/cne.20160</a>.","apa":"Luján, R., Shigemoto, R., Kulik, Á., &#38; Juíz, J. (2004). Localization of the GABAB receptor 1a/b subunit relative to glutamatergic synapses in the dorsal cochlear nucleus of the rat. <i>Journal of Comparative Neurology</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1002/cne.20160\">https://doi.org/10.1002/cne.20160</a>","mla":"Luján, Rafael, et al. “Localization of the GABAB Receptor 1a/b Subunit Relative to Glutamatergic Synapses in the Dorsal Cochlear Nucleus of the Rat.” <i>Journal of Comparative Neurology</i>, vol. 475, no. 1, Wiley-Blackwell, 2004, pp. 36–46, doi:<a href=\"https://doi.org/10.1002/cne.20160\">10.1002/cne.20160</a>.","short":"R. Luján, R. Shigemoto, Á. Kulik, J. Juíz, Journal of Comparative Neurology 475 (2004) 36–46.","ama":"Luján R, Shigemoto R, Kulik Á, Juíz J. Localization of the GABAB receptor 1a/b subunit relative to glutamatergic synapses in the dorsal cochlear nucleus of the rat. <i>Journal of Comparative Neurology</i>. 2004;475(1):36-46. doi:<a href=\"https://doi.org/10.1002/cne.20160\">10.1002/cne.20160</a>"},"author":[{"first_name":"Rafael","full_name":"Luján, Rafael","last_name":"Luján"},{"orcid":"0000-0001-8761-9444","last_name":"Shigemoto","full_name":"Ryuichi Shigemoto","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Kulik, Ákos","last_name":"Kulik","first_name":"Ákos"},{"last_name":"Juíz","full_name":"Juíz, José M","first_name":"José"}],"_id":"2643","page":"36 - 46","doi":"10.1002/cne.20160","date_updated":"2021-01-12T06:58:46Z","type":"journal_article","publication":"Journal of Comparative Neurology","date_published":"2004-07-12T00:00:00Z","day":"12","year":"2004","intvolume":"       475","issue":"1","title":"Localization of the GABAB receptor 1a/b subunit relative to glutamatergic synapses in the dorsal cochlear nucleus of the rat"}]