[{"month":"07","status":"public","year":"2007","intvolume":"       317","publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"author":[{"full_name":"Henzinger, Monika H","id":"540c9bbd-f2de-11ec-812d-d04a5be85630","orcid":"0000-0002-5008-6530","last_name":"Henzinger","first_name":"Monika H"}],"date_created":"2022-08-17T07:30:07Z","publication_status":"published","date_published":"2007-07-27T00:00:00Z","article_processing_charge":"No","pmid":1,"publication":"Science","doi":"10.1126/science.1126557","external_id":{"pmid":["17656714"]},"oa_version":"None","quality_controlled":"1","title":"Search technologies for the internet","scopus_import":"1","_id":"11884","article_type":"review","extern":"1","day":"27","publisher":"American Association for the Advancement of Science","page":"468-471","type":"journal_article","volume":317,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"About 20% of the world's population uses the Web, and a large majority thereof uses Web search engines to find information. As a result, many Web researchers are devoting much effort to improving the speed and capability of search technology."}],"date_updated":"2024-11-06T12:01:07Z","citation":{"mla":"Henzinger, Monika. “Search Technologies for the Internet.” <i>Science</i>, vol. 317, no. 5837, American Association for the Advancement of Science, 2007, pp. 468–71, doi:<a href=\"https://doi.org/10.1126/science.1126557\">10.1126/science.1126557</a>.","ama":"Henzinger M. Search technologies for the internet. <i>Science</i>. 2007;317(5837):468-471. doi:<a href=\"https://doi.org/10.1126/science.1126557\">10.1126/science.1126557</a>","short":"M. Henzinger, Science 317 (2007) 468–471.","ieee":"M. Henzinger, “Search technologies for the internet,” <i>Science</i>, vol. 317, no. 5837. American Association for the Advancement of Science, pp. 468–471, 2007.","chicago":"Henzinger, Monika. “Search Technologies for the Internet.” <i>Science</i>. American Association for the Advancement of Science, 2007. <a href=\"https://doi.org/10.1126/science.1126557\">https://doi.org/10.1126/science.1126557</a>.","apa":"Henzinger, M. (2007). Search technologies for the internet. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1126557\">https://doi.org/10.1126/science.1126557</a>","ista":"Henzinger M. 2007. Search technologies for the internet. Science. 317(5837), 468–471."},"issue":"5837"},{"year":"2007","month":"01","_id":"11924","status":"public","publisher":"Society for Industrial & Applied Mathematics","day":"01","date_created":"2022-08-18T12:37:03Z","publication_identifier":{"isbn":["9780898716245"]},"author":[{"orcid":"0000-0002-5008-6530","id":"540c9bbd-f2de-11ec-812d-d04a5be85630","full_name":"Henzinger, Monika H","first_name":"Monika H","last_name":"Henzinger"}],"extern":"1","publication_status":"published","page":"1022-1026","date_published":"2007-01-01T00:00:00Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_processing_charge":"No","type":"conference","date_updated":"2024-11-06T11:59:56Z","language":[{"iso":"eng"}],"publication":"18th Annual ACM-SIAM Symposium on Discrete Algorithms","abstract":[{"lang":"eng","text":"How much can smart combinatorial algorithms improve web search engines? To address this question we will describe three algorithms that have had a positive impact on web search engines: The PageRank algorithm, algorithms for finding near-duplicate web pages, and algorithms for index server loadbalancing."}],"citation":{"ama":"Henzinger M. Combinatorial algorithms for web search engines: three success stories. In: <i>18th Annual ACM-SIAM Symposium on Discrete Algorithms</i>. Society for Industrial &#38; Applied Mathematics; 2007:1022-1026.","short":"M. Henzinger, in:, 18th Annual ACM-SIAM Symposium on Discrete Algorithms, Society for Industrial &#38; Applied Mathematics, 2007, pp. 1022–1026.","mla":"Henzinger, Monika. “Combinatorial Algorithms for Web Search Engines: Three Success Stories.” <i>18th Annual ACM-SIAM Symposium on Discrete Algorithms</i>, Society for Industrial &#38; Applied Mathematics, 2007, pp. 1022–26.","ista":"Henzinger M. 2007. Combinatorial algorithms for web search engines: three success stories. 18th Annual ACM-SIAM Symposium on Discrete Algorithms. SODA: Symposium on Discrete Algorithms, 1022–1026.","chicago":"Henzinger, Monika. “Combinatorial Algorithms for Web Search Engines: Three Success Stories.” In <i>18th Annual ACM-SIAM Symposium on Discrete Algorithms</i>, 1022–26. Society for Industrial &#38; Applied Mathematics, 2007.","ieee":"M. Henzinger, “Combinatorial algorithms for web search engines: three success stories,” in <i>18th Annual ACM-SIAM Symposium on Discrete Algorithms</i>, New Orleans, LA, United States, 2007, pp. 1022–1026.","apa":"Henzinger, M. (2007). Combinatorial algorithms for web search engines: three success stories. In <i>18th Annual ACM-SIAM Symposium on Discrete Algorithms</i> (pp. 1022–1026). New Orleans, LA, United States: Society for Industrial &#38; Applied Mathematics."},"oa_version":"None","conference":{"location":"New Orleans, LA, United States","name":"SODA: Symposium on Discrete Algorithms","end_date":"2007-01-09","start_date":"2007-01-07"},"scopus_import":"1","quality_controlled":"1","title":"Combinatorial algorithms for web search engines: three success stories"},{"external_id":{"pmid":["17825943"]},"doi":"10.1016/j.tig.2007.08.005","oa_version":"None","quality_controlled":"1","title":"Packaging the male germline in plants","scopus_import":"1","article_processing_charge":"No","pmid":1,"publication":"Trends in Genetics","acknowledgement":"X.F. holds a Clarendon Scholarship from the University of Oxford. We thank Angela Hay and Jill Harrison for helpful advice and discussion.","department":[{"_id":"XiFe"}],"publication_status":"published","date_published":"2007-10-01T00:00:00Z","month":"10","status":"public","year":"2007","intvolume":"        23","publication_identifier":{"issn":["0168-9525"]},"author":[{"last_name":"Feng","first_name":"Xiaoqi","full_name":"Feng, Xiaoqi","id":"e0164712-22ee-11ed-b12a-d80fcdf35958","orcid":"0000-0002-4008-1234"},{"last_name":"Dickinson","first_name":"Hugh G.","full_name":"Dickinson, Hugh G."}],"date_created":"2023-01-16T09:22:44Z","citation":{"apa":"Feng, X., &#38; Dickinson, H. G. (2007). Packaging the male germline in plants. <i>Trends in Genetics</i>. Elsevier BV. <a href=\"https://doi.org/10.1016/j.tig.2007.08.005\">https://doi.org/10.1016/j.tig.2007.08.005</a>","ieee":"X. Feng and H. G. Dickinson, “Packaging the male germline in plants,” <i>Trends in Genetics</i>, vol. 23, no. 10. Elsevier BV, pp. 503–510, 2007.","chicago":"Feng, Xiaoqi, and Hugh G. Dickinson. “Packaging the Male Germline in Plants.” <i>Trends in Genetics</i>. Elsevier BV, 2007. <a href=\"https://doi.org/10.1016/j.tig.2007.08.005\">https://doi.org/10.1016/j.tig.2007.08.005</a>.","ista":"Feng X, Dickinson HG. 2007. Packaging the male germline in plants. Trends in Genetics. 23(10), 503–510.","mla":"Feng, Xiaoqi, and Hugh G. Dickinson. “Packaging the Male Germline in Plants.” <i>Trends in Genetics</i>, vol. 23, no. 10, Elsevier BV, 2007, pp. 503–10, doi:<a href=\"https://doi.org/10.1016/j.tig.2007.08.005\">10.1016/j.tig.2007.08.005</a>.","short":"X. Feng, H.G. Dickinson, Trends in Genetics 23 (2007) 503–510.","ama":"Feng X, Dickinson HG. Packaging the male germline in plants. <i>Trends in Genetics</i>. 2007;23(10):503-510. doi:<a href=\"https://doi.org/10.1016/j.tig.2007.08.005\">10.1016/j.tig.2007.08.005</a>"},"issue":"10","type":"journal_article","volume":23,"keyword":["Genetics"],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"The development of plant lateral organs is interesting because, although many of the same genes seem to be involved in the early growth of primordia, completely different gene combinations are required for the complete development of organs such as leaves and stamens. Thus, the genes common to the development of most organs, which generally form and polarize the primordial ‘envelope’, must at some stage interact with those that ‘install’ the functional content of the organ – in the case of the stamen, the four microsporangia. Although distinct genetic pathways of organ initiation, polarity establishment and setting up the reproductive cell line can readily be recognized, they do not occur sequentially. Rather, they are activated early and run in parallel. There is evidence for continuing crosstalk between these pathways."}],"date_updated":"2023-05-08T10:58:47Z","page":"503-510","article_type":"original","_id":"12201","extern":"1","publisher":"Elsevier BV"},{"volume":144,"type":"journal_article","date_updated":"2021-01-12T06:58:55Z","publication":"Neuroscience","abstract":[{"text":"Substance P (SP) is known to be a peptide that facilitates epileptic activity of principal cells in the hippocampus. Paradoxically, in other models, it was found to be protective against seizures by activating substance P receptor (SPR)-expressing interneurons. Thus, these cells appear to play an important role in the generation and regulation of epileptic seizures. The number, distribution, morphological features and input characteristics of SPR-immunoreactive cells were analyzed in surgically removed hippocampi of 28 temporal lobe epileptic patients and eight control hippocampi in order to examine their changes in epileptic tissues. SPR is expressed in a subset of inhibitory cells in the control human hippocampus, they are multipolar interneurons with smooth dendrites, present in all hippocampal subfields. This cell population is considerably different from SPR-positive cells of the rat hippocampus. The CA1 (cornu Ammonis subfield 1) region was chosen for the detailed morphological analysis of the SPR-immunoreactive cells because of its extreme vulnerability in epilepsy. The presence of various neurochemical markers identifies functionally distinct interneuron types, such as those responsible for perisomatic, dendritic or interneuron-selective inhibition. We found considerable colocalization of SPR with calbindin but not with parvalbumin, calretinin, cholecystokinin and somatostatin, therefore we suppose that SPR-positive cells participate mainly in dendritic inhibition. In the non-sclerotic CA1 region they are mainly preserved, whereas their number is decreased in the sclerotic cases. In the epileptic samples their morphology is considerably altered, they possessed more dendritic branches, which often became beaded. Analyses of synaptic coverage revealed that the ratio of symmetric synaptic input of SPR-immunoreactive cells has increased in epileptic samples. Our results suggest that SPR-positive cells are preserved while principal cells are present in the CA1 region, but show reactive changes in epilepsy including intense branching and growth of their dendritic arborization.","lang":"eng"}],"citation":{"mla":"Tóth, Kinga, et al. “Morphology and Synaptic Input of Substance P Receptor-Immunoreactive Interneurons in Control and Epileptic Human Hippocampus.” <i>Neuroscience</i>, vol. 144, no. 2, Elsevier, 2007, pp. 495–508, doi:<a href=\"https://doi.org/10.1016/j.neuroscience.2006.09.039\">10.1016/j.neuroscience.2006.09.039</a>.","ama":"Tóth K, Wittner L, Urbán Z, et al. Morphology and synaptic input of substance P receptor-immunoreactive interneurons in control and epileptic human hippocampus. <i>Neuroscience</i>. 2007;144(2):495-508. doi:<a href=\"https://doi.org/10.1016/j.neuroscience.2006.09.039\">10.1016/j.neuroscience.2006.09.039</a>","short":"K. Tóth, L. Wittner, Z. Urbán, W. Doyle, G. Buzsáki, R. Shigemoto, T. Freund, Z. Maglóczky, Neuroscience 144 (2007) 495–508.","chicago":"Tóth, Kinga, Lucia Wittner, Z Urbán, Werner Doyle, György Buzsáki, Ryuichi Shigemoto, Tamás Freund, and Zsófia Maglóczky. “Morphology and Synaptic Input of Substance P Receptor-Immunoreactive Interneurons in Control and Epileptic Human Hippocampus.” <i>Neuroscience</i>. Elsevier, 2007. <a href=\"https://doi.org/10.1016/j.neuroscience.2006.09.039\">https://doi.org/10.1016/j.neuroscience.2006.09.039</a>.","ieee":"K. Tóth <i>et al.</i>, “Morphology and synaptic input of substance P receptor-immunoreactive interneurons in control and epileptic human hippocampus,” <i>Neuroscience</i>, vol. 144, no. 2. Elsevier, pp. 495–508, 2007.","apa":"Tóth, K., Wittner, L., Urbán, Z., Doyle, W., Buzsáki, G., Shigemoto, R., … Maglóczky, Z. (2007). Morphology and synaptic input of substance P receptor-immunoreactive interneurons in control and epileptic human hippocampus. <i>Neuroscience</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.neuroscience.2006.09.039\">https://doi.org/10.1016/j.neuroscience.2006.09.039</a>","ista":"Tóth K, Wittner L, Urbán Z, Doyle W, Buzsáki G, Shigemoto R, Freund T, Maglóczky Z. 2007. Morphology and synaptic input of substance P receptor-immunoreactive interneurons in control and epileptic human hippocampus. Neuroscience. 144(2), 495–508."},"doi":"10.1016/j.neuroscience.2006.09.039","issue":"2","quality_controlled":0,"title":"Morphology and synaptic input of substance P receptor-immunoreactive interneurons in control and epileptic human hippocampus","year":"2007","_id":"2665","month":"01","status":"public","day":"19","publisher":"Elsevier","date_created":"2018-12-11T11:58:57Z","intvolume":"       144","publist_id":"4232","author":[{"last_name":"Tóth","first_name":"Kinga","full_name":"Tóth, Kinga"},{"full_name":"Wittner, Lucia","first_name":"Lucia","last_name":"Wittner"},{"first_name":"Z","last_name":"Urbán","full_name":"Urbán, Z"},{"first_name":"Werner","last_name":"Doyle","full_name":"Doyle, Werner K"},{"last_name":"Buzsáki","first_name":"György","full_name":"Buzsáki, György"},{"last_name":"Shigemoto","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Ryuichi Shigemoto","orcid":"0000-0001-8761-9444"},{"full_name":"Freund, Tamás F","last_name":"Freund","first_name":"Tamás"},{"full_name":"Maglóczky, Zsófia","first_name":"Zsófia","last_name":"Maglóczky"}],"extern":1,"page":"495 - 508","publication_status":"published","date_published":"2007-01-19T00:00:00Z"},{"date_published":"2007-02-01T00:00:00Z","page":"822 - 840","publication_status":"published","author":[{"first_name":"Karen","last_name":"Luyt","full_name":"Luyt, Karen"},{"full_name":"Slade, Timothy P","first_name":"Timothy","last_name":"Slade"},{"full_name":"Dorward, Jienchi J","last_name":"Dorward","first_name":"Jienchi"},{"full_name":"Durant, Claire F","first_name":"Claire","last_name":"Durant"},{"last_name":"Wu","first_name":"Yue","full_name":"Wu, Yue"},{"first_name":"Ryuichi","last_name":"Shigemoto","orcid":"0000-0001-8761-9444","full_name":"Ryuichi Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Mundell, Stuart J","first_name":"Stuart","last_name":"Mundell"},{"first_name":"Anikó","last_name":"Váradi","full_name":"Váradi, Anikó"},{"first_name":"Elek","last_name":"Molnár","full_name":"Molnár, Elek"}],"extern":1,"intvolume":"       100","publist_id":"4231","date_created":"2018-12-11T11:58:57Z","day":"01","publisher":"Wiley-Blackwell","status":"public","month":"02","_id":"2666","year":"2007","title":"Developing oligodendrocytes express functional GABAB receptors that stimulate cell proliferation and migration","quality_controlled":0,"issue":"3","doi":"10.1111/j.1471-4159.2006.04255.x","citation":{"ista":"Luyt K, Slade T, Dorward J, Durant C, Wu Y, Shigemoto R, Mundell S, Váradi A, Molnár E. 2007. Developing oligodendrocytes express functional GABAB receptors that stimulate cell proliferation and migration. Journal of Neurochemistry. 100(3), 822–840.","apa":"Luyt, K., Slade, T., Dorward, J., Durant, C., Wu, Y., Shigemoto, R., … Molnár, E. (2007). Developing oligodendrocytes express functional GABAB receptors that stimulate cell proliferation and migration. <i>Journal of Neurochemistry</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1111/j.1471-4159.2006.04255.x\">https://doi.org/10.1111/j.1471-4159.2006.04255.x</a>","ieee":"K. Luyt <i>et al.</i>, “Developing oligodendrocytes express functional GABAB receptors that stimulate cell proliferation and migration,” <i>Journal of Neurochemistry</i>, vol. 100, no. 3. Wiley-Blackwell, pp. 822–840, 2007.","chicago":"Luyt, Karen, Timothy Slade, Jienchi Dorward, Claire Durant, Yue Wu, Ryuichi Shigemoto, Stuart Mundell, Anikó Váradi, and Elek Molnár. “Developing Oligodendrocytes Express Functional GABAB Receptors That Stimulate Cell Proliferation and Migration.” <i>Journal of Neurochemistry</i>. Wiley-Blackwell, 2007. <a href=\"https://doi.org/10.1111/j.1471-4159.2006.04255.x\">https://doi.org/10.1111/j.1471-4159.2006.04255.x</a>.","short":"K. Luyt, T. Slade, J. Dorward, C. Durant, Y. Wu, R. Shigemoto, S. Mundell, A. Váradi, E. Molnár, Journal of Neurochemistry 100 (2007) 822–840.","ama":"Luyt K, Slade T, Dorward J, et al. Developing oligodendrocytes express functional GABAB receptors that stimulate cell proliferation and migration. <i>Journal of Neurochemistry</i>. 2007;100(3):822-840. doi:<a href=\"https://doi.org/10.1111/j.1471-4159.2006.04255.x\">10.1111/j.1471-4159.2006.04255.x</a>","mla":"Luyt, Karen, et al. “Developing Oligodendrocytes Express Functional GABAB Receptors That Stimulate Cell Proliferation and Migration.” <i>Journal of Neurochemistry</i>, vol. 100, no. 3, Wiley-Blackwell, 2007, pp. 822–40, doi:<a href=\"https://doi.org/10.1111/j.1471-4159.2006.04255.x\">10.1111/j.1471-4159.2006.04255.x</a>."},"abstract":[{"text":"GABAB receptors (GABABRs) are involved in early events during neuronal development. The presence of GABABRs in developing oligodendrocytes has not been established. Using immunofluorescent co-localization, we have identified GABABR proteins in O4 marker-positive oligodendrocyte precursor cells (OPCs) in 4-day-old mouse brain periventricular white matter. In culture, OPCs, differentiated oligodendrocytes (DOs) and type 2 astrocytes (ASTs) express both the GABAB1abcdf and GABAB2 subunits of the GABABR. Using semiquantitative PCR analysis with GABABR isoform-selective primers we found that the expression level of GABAB1abd was substantially higher in OPCs or ASTs than in DOs. In contrast, the GABAB2 isoform showed a similar level of expression in OPCs and DOs, and a significantly higher level in ASTs. This indicates that the expression of GABAB1 and GABAB2 subunits are under independent control during oligodendroglial development. Activation of GABABRs using the selective agonist baclofen demonstrated that these receptors are functionally active and negatively coupled to adenylyl cyclase. Manipulation of GABABR activity had no effect on OPC migration in a conventional agarose drop assay, whereas baclofen significantly increased OPC migration in a more sensitive transwell microchamber-based assay. Exposure of cultured OPCs to baclofen increased their proliferation, providing evidence for a functional role of GABABRs in oligodendrocyte development. The presence of GABABRs in developing oligodendrocytes provides a new mechanism for neuronal-glial interactions during development and may offer a novel target for promoting remyelination following white matter injury.","lang":"eng"}],"publication":"Journal of Neurochemistry","date_updated":"2021-01-12T06:58:55Z","volume":100,"type":"journal_article"},{"publication_status":"published","page":"2135 - 2144","date_published":"2007-02-21T00:00:00Z","status":"public","_id":"2667","month":"02","year":"2007","extern":1,"author":[{"full_name":"Masugi-Tokita, Miwako","first_name":"Miwako","last_name":"Masugi Tokita"},{"last_name":"Tarusawa","first_name":"Etsuko","full_name":"Tarusawa, Etsuko"},{"last_name":"Watanabe","first_name":"Masahiko","full_name":"Watanabe, Masahiko"},{"first_name":"Elek","last_name":"Molnár","full_name":"Molnár, Elek"},{"full_name":"Fujimoto, Kazushi","last_name":"Fujimoto","first_name":"Kazushi"},{"first_name":"Ryuichi","last_name":"Shigemoto","orcid":"0000-0001-8761-9444","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Ryuichi Shigemoto"}],"publist_id":"4230","intvolume":"        27","date_created":"2018-12-11T11:58:58Z","publisher":"Society for Neuroscience","day":"21","doi":"10.1523/JNEUROSCI.2861-06.2007","citation":{"ista":"Masugi Tokita M, Tarusawa E, Watanabe M, Molnár E, Fujimoto K, Shigemoto R. 2007. Number and density of AMPA receptors in individual synapses in the rat cerebellum as revealed by SDS-digested freeze-fracture replica labeling. Journal of Neuroscience. 27(8), 2135–2144.","chicago":"Masugi Tokita, Miwako, Etsuko Tarusawa, Masahiko Watanabe, Elek Molnár, Kazushi Fujimoto, and Ryuichi Shigemoto. “Number and Density of AMPA Receptors in Individual Synapses in the Rat Cerebellum as Revealed by SDS-Digested Freeze-Fracture Replica Labeling.” <i>Journal of Neuroscience</i>. Society for Neuroscience, 2007. <a href=\"https://doi.org/10.1523/JNEUROSCI.2861-06.2007\">https://doi.org/10.1523/JNEUROSCI.2861-06.2007</a>.","ieee":"M. Masugi Tokita, E. Tarusawa, M. Watanabe, E. Molnár, K. Fujimoto, and R. Shigemoto, “Number and density of AMPA receptors in individual synapses in the rat cerebellum as revealed by SDS-digested freeze-fracture replica labeling,” <i>Journal of Neuroscience</i>, vol. 27, no. 8. Society for Neuroscience, pp. 2135–2144, 2007.","apa":"Masugi Tokita, M., Tarusawa, E., Watanabe, M., Molnár, E., Fujimoto, K., &#38; Shigemoto, R. (2007). Number and density of AMPA receptors in individual synapses in the rat cerebellum as revealed by SDS-digested freeze-fracture replica labeling. <i>Journal of Neuroscience</i>. Society for Neuroscience. <a href=\"https://doi.org/10.1523/JNEUROSCI.2861-06.2007\">https://doi.org/10.1523/JNEUROSCI.2861-06.2007</a>","ama":"Masugi Tokita M, Tarusawa E, Watanabe M, Molnár E, Fujimoto K, Shigemoto R. Number and density of AMPA receptors in individual synapses in the rat cerebellum as revealed by SDS-digested freeze-fracture replica labeling. <i>Journal of Neuroscience</i>. 2007;27(8):2135-2144. doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.2861-06.2007\">10.1523/JNEUROSCI.2861-06.2007</a>","short":"M. Masugi Tokita, E. Tarusawa, M. Watanabe, E. Molnár, K. Fujimoto, R. Shigemoto, Journal of Neuroscience 27 (2007) 2135–2144.","mla":"Masugi Tokita, Miwako, et al. “Number and Density of AMPA Receptors in Individual Synapses in the Rat Cerebellum as Revealed by SDS-Digested Freeze-Fracture Replica Labeling.” <i>Journal of Neuroscience</i>, vol. 27, no. 8, Society for Neuroscience, 2007, pp. 2135–44, doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.2861-06.2007\">10.1523/JNEUROSCI.2861-06.2007</a>."},"title":"Number and density of AMPA receptors in individual synapses in the rat cerebellum as revealed by SDS-digested freeze-fracture replica labeling","quality_controlled":0,"issue":"8","type":"journal_article","volume":27,"publication":"Journal of Neuroscience","abstract":[{"text":"The number of AMPA receptor (AMPAR) is the major determinant of synaptic strength at glutamatergic synapses, but little is known about the absolute number and density of AMPARs in individual synapses. Using SDS-digested freeze-fracture replica labeling, which has high detection efficiency comparable with electrophysiological noise analysis for functional AMPAR, we analyzed three kinds of excitatory synapses in the molecular layer of the adult rat cerebellum. In parallel fiber (PF)-Purkinje cell (PC) synapses, we found large variability in the number (38.1 ± 34.4 particles per synapse, mean ± SD; range, 2-178 particles per synapse) and density (437 ± 277 particles/μm2; range, 48-1210 particles/μm2) of immunogold-labeled AMPARs. Two-dimensional view and high sensitivity of this method revealed irregular-shaped small AMPAR clusters within synapses. Climbing fiber (CF)-PC synapses had higher number of AMPAR labeling (68.6 ± 34.5 particles per synapse) than PF-PC and PF-interneuron synapses (36.8 ± 14.4 particles per synapse). Furthermore, AMPAR density at CF-PC and PF-interneuron synapses was approximately five times higher and more uniform than that at PF-PC synapses. These results suggest input- and target-dependent regulation of AMPAR-mediated synaptic strength.","lang":"eng"}],"date_updated":"2021-01-12T06:58:55Z"},{"date_created":"2018-12-11T11:58:58Z","publisher":"Wiley-Blackwell","day":"01","author":[{"last_name":"Boyes","first_name":"Justin","full_name":"Boyes, Justin"},{"full_name":"Bolam, John P","first_name":"John","last_name":"Bolam"},{"first_name":"Ryuichi","last_name":"Shigemoto","orcid":"0000-0001-8761-9444","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Ryuichi Shigemoto"},{"last_name":"Stanford","first_name":"Ian","full_name":"Stanford, Ian M"}],"extern":1,"publist_id":"4228","intvolume":"        25","year":"2007","status":"public","_id":"2668","month":"04","date_published":"2007-04-01T00:00:00Z","publication_status":"published","page":"2081 - 2092","date_updated":"2021-01-12T06:58:56Z","abstract":[{"text":"Hyperpolarization-activated, cyclic nucleotide-gated cation (HCN) channels are expressed postsynaptically in the rodent globus pallidus (GP), where they play several important roles in controlling GP neuronal activity. To further elucidate the role of HCN channels in the GP, immunocytochemical and electrophysiological approaches were used to test the hypothesis that HCN channels are also expressed presynaptically on the local axon collaterals of GP neurons. At the electron microscopic level, immunoperoxidase labelling for HCN1 and HCN2 was localized in GP somata and dendritic processes, myelinated and unmyelinated axons, and axon terminals. One population of labelled terminals formed symmetric synapses with somata and proximal dendrites and were immunoreactive for parvalbumin, consistent with the axon collaterals of GABAergic GP projection neurons. In addition, labelling for HCN2 and, to a lesser degree, HCN1 was observed in axon terminals that formed asymmetric synapses and were immunoreactive for the vesicular glutamate transporter 2. Immunogold labelling demonstrated that HCN1 and HCN2 were located predominantly at extrasynaptic sites along the plasma membrane of both types of terminal. To determine the function of presynaptic HCN channels in the GP, we performed whole-cell recordings from GP neurons in vitro. Bath application of the HCN channel blocker ZD7288 resulted in an increase in the frequency of mIPSCs but had no effect on their amplitude, implying that HCN channels tonically regulate the release of GABA. Their presence, and predicted role in modulating transmitter release, represents a hitherto unidentified mechanism whereby HCN channels influence the activity of GP neurons.","lang":"eng"}],"publication":"European Journal of Neuroscience","type":"journal_article","volume":25,"issue":"7","title":"Functional presynaptic HCN channels in the rat globus pallidus","quality_controlled":0,"citation":{"short":"J. Boyes, J. Bolam, R. Shigemoto, I. Stanford, European Journal of Neuroscience 25 (2007) 2081–2092.","ama":"Boyes J, Bolam J, Shigemoto R, Stanford I. Functional presynaptic HCN channels in the rat globus pallidus. <i>European Journal of Neuroscience</i>. 2007;25(7):2081-2092. doi:<a href=\"https://doi.org/10.1111/j.1460-9568.2007.05463.x\">10.1111/j.1460-9568.2007.05463.x</a>","mla":"Boyes, Justin, et al. “Functional Presynaptic HCN Channels in the Rat Globus Pallidus.” <i>European Journal of Neuroscience</i>, vol. 25, no. 7, Wiley-Blackwell, 2007, pp. 2081–92, doi:<a href=\"https://doi.org/10.1111/j.1460-9568.2007.05463.x\">10.1111/j.1460-9568.2007.05463.x</a>.","ista":"Boyes J, Bolam J, Shigemoto R, Stanford I. 2007. Functional presynaptic HCN channels in the rat globus pallidus. European Journal of Neuroscience. 25(7), 2081–2092.","apa":"Boyes, J., Bolam, J., Shigemoto, R., &#38; Stanford, I. (2007). Functional presynaptic HCN channels in the rat globus pallidus. <i>European Journal of Neuroscience</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1111/j.1460-9568.2007.05463.x\">https://doi.org/10.1111/j.1460-9568.2007.05463.x</a>","chicago":"Boyes, Justin, John Bolam, Ryuichi Shigemoto, and Ian Stanford. “Functional Presynaptic HCN Channels in the Rat Globus Pallidus.” <i>European Journal of Neuroscience</i>. Wiley-Blackwell, 2007. <a href=\"https://doi.org/10.1111/j.1460-9568.2007.05463.x\">https://doi.org/10.1111/j.1460-9568.2007.05463.x</a>.","ieee":"J. Boyes, J. Bolam, R. Shigemoto, and I. Stanford, “Functional presynaptic HCN channels in the rat globus pallidus,” <i>European Journal of Neuroscience</i>, vol. 25, no. 7. Wiley-Blackwell, pp. 2081–2092, 2007."},"doi":"10.1111/j.1460-9568.2007.05463.x"},{"publication":"Cerebral Cortex","abstract":[{"lang":"eng","text":"The properties of the hyperpolarization-activated current (Ih) and its roles in hippocampal network function evolve radically during development. Because Ih is conducted by the hyperpolarization- activated cyclic nucleotide-gated (HCN) cation channels, we tested the hypothesis that understanding the quantitative developmental profiles of HCN1, HCN2, and HCN4 expression, and the isoform- and age-specific progression of their subcellular distribution, should shed light on the established modifications of the properties of Ih throughout development. Combined quantitative in situ hybridization, regional western blots, and high-resolution, dual-label immunocytochemistry revealed striking and novel information about the expression and distribution of the HCN channel isoforms in the developing hippocampal formation. In cornus ammon 1 (CA) pyramidal cell layer, a robust increase of HCN1 mRNA and protein expression occurred with age, with reciprocal reduction of HCN4 and relatively stable HCN2 levels. These distinct expression patterns raised the contribution of HCN1 to the total HCN channel pool from 33% to 65% consonant with acceleration and reduced cyclic adenosine mono phosphate (cAMP) sensitivity of Ih in this region with age. In CA3, strong expression of HCN1 already neonatally supports the recently established role of this conductance in neonatal, age-specific, hippocampal oscillations (giant depolarizing potentials). Notably, HCN1 channels were present and probably transported to dendritic compartments already on postnatal day (P) 2, whereas HCN2 channel protein was not evident in dendrites for the first 2 weeks of life. HCN2 mRNA and protein expression remained fairly constant subsequent to the first week of life in all hippocampal subfields examined, whereas HCN4 mRNA and protein expression declined after maximal neonatal expression, so that the contribution of this isoform to the total HCN channel pool dropped from 43% (CA1) and 34% (CA3) on P11 to 8% (CA1) and 19% (CA3) on P90. Interneuronal expression of all HCN channel isoforms in stratum pyramidale was robust in parvalbumin-but not in cholecystokinin-expressing populations and with a subunit-specific subcellular distribution. Taken together, these data suggest that early in life, HCN4 may contribute significantly to the functions of Ih in specific hippocampal regions. In addition, these evolving, differential quantitative, and subcellular expression patterns of the HCN channel isoforms support age-specific properties and functions of Ih within the developing hippocampal formation."}],"date_updated":"2021-01-12T06:58:56Z","type":"journal_article","volume":17,"title":"Quantitative analysis and subcellular distribution of mRNA and protein expression of the hyperpolarization-activated cyclic nucleotide-gated channels throughout development in rat hippocampus","quality_controlled":0,"issue":"3","citation":{"mla":"Brewster, Amy, et al. “Quantitative Analysis and Subcellular Distribution of MRNA and Protein Expression of the Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels throughout Development in Rat Hippocampus.” <i>Cerebral Cortex</i>, vol. 17, no. 3, Oxford University Press, 2007, pp. 702–12, doi:<a href=\"https://doi.org/10.1093/cercor/bhk021\">10.1093/cercor/bhk021</a>.","short":"A. Brewster, Y. Chen, R. Bender, A. Yeh, R. Shigemoto, T. Baram, Cerebral Cortex 17 (2007) 702–712.","ama":"Brewster A, Chen Y, Bender R, Yeh A, Shigemoto R, Baram T. Quantitative analysis and subcellular distribution of mRNA and protein expression of the hyperpolarization-activated cyclic nucleotide-gated channels throughout development in rat hippocampus. <i>Cerebral Cortex</i>. 2007;17(3):702-712. doi:<a href=\"https://doi.org/10.1093/cercor/bhk021\">10.1093/cercor/bhk021</a>","apa":"Brewster, A., Chen, Y., Bender, R., Yeh, A., Shigemoto, R., &#38; Baram, T. (2007). Quantitative analysis and subcellular distribution of mRNA and protein expression of the hyperpolarization-activated cyclic nucleotide-gated channels throughout development in rat hippocampus. <i>Cerebral Cortex</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/cercor/bhk021\">https://doi.org/10.1093/cercor/bhk021</a>","ieee":"A. Brewster, Y. Chen, R. Bender, A. Yeh, R. Shigemoto, and T. Baram, “Quantitative analysis and subcellular distribution of mRNA and protein expression of the hyperpolarization-activated cyclic nucleotide-gated channels throughout development in rat hippocampus,” <i>Cerebral Cortex</i>, vol. 17, no. 3. Oxford University Press, pp. 702–712, 2007.","chicago":"Brewster, Amy, Yuncai Chen, Roland Bender, Amy Yeh, Ryuichi Shigemoto, and Tallie Baram. “Quantitative Analysis and Subcellular Distribution of MRNA and Protein Expression of the Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels throughout Development in Rat Hippocampus.” <i>Cerebral Cortex</i>. Oxford University Press, 2007. <a href=\"https://doi.org/10.1093/cercor/bhk021\">https://doi.org/10.1093/cercor/bhk021</a>.","ista":"Brewster A, Chen Y, Bender R, Yeh A, Shigemoto R, Baram T. 2007. Quantitative analysis and subcellular distribution of mRNA and protein expression of the hyperpolarization-activated cyclic nucleotide-gated channels throughout development in rat hippocampus. Cerebral Cortex. 17(3), 702–712."},"doi":"10.1093/cercor/bhk021","extern":1,"author":[{"first_name":"Amy","last_name":"Brewster","full_name":"Brewster, Amy L"},{"last_name":"Chen","first_name":"Yuncai","full_name":"Chen, Yuncai"},{"full_name":"Bender, Roland A","first_name":"Roland","last_name":"Bender"},{"full_name":"Yeh, Amy","first_name":"Amy","last_name":"Yeh"},{"first_name":"Ryuichi","last_name":"Shigemoto","orcid":"0000-0001-8761-9444","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Ryuichi Shigemoto"},{"last_name":"Baram","first_name":"Tallie","full_name":"Baram, Tallie Z"}],"publist_id":"4229","intvolume":"        17","date_created":"2018-12-11T11:58:58Z","publisher":"Oxford University Press","day":"01","status":"public","month":"03","_id":"2669","year":"2007","date_published":"2007-03-01T00:00:00Z","page":"702 - 712","publication_status":"published"},{"title":"High-resolution quantitative visualization of glutamate and GABA receptors at central synapses","quality_controlled":0,"issue":"3","doi":"10.1016/j.conb.2007.04.012","citation":{"short":"M. Masugi Tokita, R. Shigemoto, Current Opinion in Neurobiology 17 (2007) 387–393.","ama":"Masugi Tokita M, Shigemoto R. High-resolution quantitative visualization of glutamate and GABA receptors at central synapses. <i>Current Opinion in Neurobiology</i>. 2007;17(3):387-393. doi:<a href=\"https://doi.org/10.1016/j.conb.2007.04.012\">10.1016/j.conb.2007.04.012</a>","mla":"Masugi Tokita, Miwako, and Ryuichi Shigemoto. “High-Resolution Quantitative Visualization of Glutamate and GABA Receptors at Central Synapses.” <i>Current Opinion in Neurobiology</i>, vol. 17, no. 3, Elsevier, 2007, pp. 387–93, doi:<a href=\"https://doi.org/10.1016/j.conb.2007.04.012\">10.1016/j.conb.2007.04.012</a>.","ista":"Masugi Tokita M, Shigemoto R. 2007. High-resolution quantitative visualization of glutamate and GABA receptors at central synapses. Current Opinion in Neurobiology. 17(3), 387–393.","apa":"Masugi Tokita, M., &#38; Shigemoto, R. (2007). High-resolution quantitative visualization of glutamate and GABA receptors at central synapses. <i>Current Opinion in Neurobiology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.conb.2007.04.012\">https://doi.org/10.1016/j.conb.2007.04.012</a>","ieee":"M. Masugi Tokita and R. Shigemoto, “High-resolution quantitative visualization of glutamate and GABA receptors at central synapses,” <i>Current Opinion in Neurobiology</i>, vol. 17, no. 3. Elsevier, pp. 387–393, 2007.","chicago":"Masugi Tokita, Miwako, and Ryuichi Shigemoto. “High-Resolution Quantitative Visualization of Glutamate and GABA Receptors at Central Synapses.” <i>Current Opinion in Neurobiology</i>. Elsevier, 2007. <a href=\"https://doi.org/10.1016/j.conb.2007.04.012\">https://doi.org/10.1016/j.conb.2007.04.012</a>."},"publication":"Current Opinion in Neurobiology","abstract":[{"text":"Glutamate and GABA are the main transmitters in the central nervous system and their effects are mediated by ionotropic and metabotropic receptors. Immunogold electron microscopy has revealed the quantitative localization of these receptors at 20-30 nm resolution. SDS-digested freeze-fracture replica labeling (SDS-FRL), a newly developed immunogold method, provides an accurate estimate of molecule numbers. Here, we summarize the recent advances in quantitative receptor localization, including use of SDS-FRL analyses to determine numbers of AMPA-type glutamate receptors in the cerebellum. The two-dimensional view and high sensitivity of SDS-FRL have revealed small, irregularly shaped AMPA receptor clusters within cerebellar synapses.","lang":"eng"}],"date_updated":"2020-07-14T12:45:44Z","volume":17,"type":"review","date_published":"2007-06-01T00:00:00Z","publication_status":"published","page":"387 - 393","author":[{"full_name":"Masugi-Tokita, Miwako","first_name":"Miwako","last_name":"Masugi Tokita"},{"last_name":"Shigemoto","first_name":"Ryuichi","full_name":"Ryuichi Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8761-9444"}],"extern":1,"publist_id":"4226","intvolume":"        17","date_created":"2018-12-11T11:58:58Z","day":"01","publisher":"Elsevier","status":"public","month":"06","_id":"2670","year":"2007"},{"status":"public","month":"04","_id":"2671","year":"2007","extern":1,"author":[{"full_name":"Bender, Roland A","first_name":"Roland","last_name":"Bender"},{"first_name":"Timo","last_name":"Kirschstein","full_name":"Kirschstein, Timo"},{"full_name":"Kretz, Oliver","first_name":"Oliver","last_name":"Kretz"},{"full_name":"Brewster, Amy L","last_name":"Brewster","first_name":"Amy"},{"first_name":"Cristina","last_name":"Richichi","full_name":"Richichi, Cristina"},{"full_name":"Rüschenschmidt, Christiane","first_name":"Christiane","last_name":"Rüschenschmidt"},{"full_name":"Ryuichi Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8761-9444","last_name":"Shigemoto","first_name":"Ryuichi"},{"full_name":"Beck,Heinz","last_name":"Beck","first_name":"Heinz"},{"full_name":"Frotscher, Michael","last_name":"Frotscher","first_name":"Michael"},{"full_name":"Baram, Tallie Z","first_name":"Tallie","last_name":"Baram"}],"intvolume":"        27","publist_id":"4227","date_created":"2018-12-11T11:58:59Z","publisher":"Society for Neuroscience","day":"25","publication_status":"published","page":"4697 - 4706","date_published":"2007-04-25T00:00:00Z","volume":27,"type":"journal_article","abstract":[{"text":"Increasing evidence supports roles for the current mediated by hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, I h, in hippocampal maturation and specifically in the evolving changes of intrinsic properties as well as network responses of hippocampal neurons. Here, we describe a novel developmental plasticity of HCN channel expression in axonal and presynaptic compartments: HCN1 channels were localized to axon terminals of the perforant path (the major hippocampal afferent pathway) of immature rats, where they modulated synaptic efficacy. However, presynaptic expression and functions of the channels disappeared with maturation. This was a result of altered channel transport to the axons, because HCN1 mRNA and protein levels in entorhinal cortex neurons, where the perforant path axons originate, were stable through adulthood. Blocking action potential firing in vitro increased presynaptic expression of HCN1 channels in the perforant path, suggesting that network activity contributed to regulating this expression. These findings support a novel developmentally regulated axonal transport of functional ion channels and suggest a role for HCN1 channel-mediated presynaptic I h in hippocampal maturation.","lang":"eng"}],"publication":"Journal of Neuroscience","date_updated":"2021-01-12T06:58:57Z","doi":"10.1523/JNEUROSCI.4699-06.2007","citation":{"mla":"Bender, Roland, et al. “Localization of HCN1 Channels to Presynaptic Compartments: Novel Plasticity That May Contribute to Hippocampal Maturation.” <i>Journal of Neuroscience</i>, vol. 27, no. 17, Society for Neuroscience, 2007, pp. 4697–706, doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.4699-06.2007\">10.1523/JNEUROSCI.4699-06.2007</a>.","ama":"Bender R, Kirschstein T, Kretz O, et al. Localization of HCN1 channels to presynaptic compartments: Novel plasticity that may contribute to hippocampal maturation. <i>Journal of Neuroscience</i>. 2007;27(17):4697-4706. doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.4699-06.2007\">10.1523/JNEUROSCI.4699-06.2007</a>","short":"R. Bender, T. Kirschstein, O. Kretz, A. Brewster, C. Richichi, C. Rüschenschmidt, R. Shigemoto, H. Beck, M. Frotscher, T. Baram, Journal of Neuroscience 27 (2007) 4697–4706.","ieee":"R. Bender <i>et al.</i>, “Localization of HCN1 channels to presynaptic compartments: Novel plasticity that may contribute to hippocampal maturation,” <i>Journal of Neuroscience</i>, vol. 27, no. 17. Society for Neuroscience, pp. 4697–4706, 2007.","chicago":"Bender, Roland, Timo Kirschstein, Oliver Kretz, Amy Brewster, Cristina Richichi, Christiane Rüschenschmidt, Ryuichi Shigemoto, Heinz Beck, Michael Frotscher, and Tallie Baram. “Localization of HCN1 Channels to Presynaptic Compartments: Novel Plasticity That May Contribute to Hippocampal Maturation.” <i>Journal of Neuroscience</i>. Society for Neuroscience, 2007. <a href=\"https://doi.org/10.1523/JNEUROSCI.4699-06.2007\">https://doi.org/10.1523/JNEUROSCI.4699-06.2007</a>.","apa":"Bender, R., Kirschstein, T., Kretz, O., Brewster, A., Richichi, C., Rüschenschmidt, C., … Baram, T. (2007). Localization of HCN1 channels to presynaptic compartments: Novel plasticity that may contribute to hippocampal maturation. <i>Journal of Neuroscience</i>. Society for Neuroscience. <a href=\"https://doi.org/10.1523/JNEUROSCI.4699-06.2007\">https://doi.org/10.1523/JNEUROSCI.4699-06.2007</a>","ista":"Bender R, Kirschstein T, Kretz O, Brewster A, Richichi C, Rüschenschmidt C, Shigemoto R, Beck H, Frotscher M, Baram T. 2007. Localization of HCN1 channels to presynaptic compartments: Novel plasticity that may contribute to hippocampal maturation. Journal of Neuroscience. 27(17), 4697–4706."},"title":"Localization of HCN1 channels to presynaptic compartments: Novel plasticity that may contribute to hippocampal maturation","quality_controlled":0,"issue":"17"},{"doi":"10.1074/jbc.M610978200","citation":{"ieee":"G. Whitaker, D. Angoli, H. Nazzari, R. Shigemoto, and E. Accili, “HCN2 and HCN4 isoforms self-assemble and co-assemble with equal preference to form functional pacemaker channels,” <i>Journal of Biological Chemistry</i>, vol. 282, no. 31. American Society for Biochemistry and Molecular Biology, pp. 22900–22909, 2007.","chicago":"Whitaker, Gina, Damiano Angoli, Hamed Nazzari, Ryuichi Shigemoto, and Eric Accili. “HCN2 and HCN4 Isoforms Self-Assemble and Co-Assemble with Equal Preference to Form Functional Pacemaker Channels.” <i>Journal of Biological Chemistry</i>. American Society for Biochemistry and Molecular Biology, 2007. <a href=\"https://doi.org/10.1074/jbc.M610978200\">https://doi.org/10.1074/jbc.M610978200</a>.","apa":"Whitaker, G., Angoli, D., Nazzari, H., Shigemoto, R., &#38; Accili, E. (2007). HCN2 and HCN4 isoforms self-assemble and co-assemble with equal preference to form functional pacemaker channels. <i>Journal of Biological Chemistry</i>. American Society for Biochemistry and Molecular Biology. <a href=\"https://doi.org/10.1074/jbc.M610978200\">https://doi.org/10.1074/jbc.M610978200</a>","ista":"Whitaker G, Angoli D, Nazzari H, Shigemoto R, Accili E. 2007. HCN2 and HCN4 isoforms self-assemble and co-assemble with equal preference to form functional pacemaker channels. Journal of Biological Chemistry. 282(31), 22900–22909.","mla":"Whitaker, Gina, et al. “HCN2 and HCN4 Isoforms Self-Assemble and Co-Assemble with Equal Preference to Form Functional Pacemaker Channels.” <i>Journal of Biological Chemistry</i>, vol. 282, no. 31, American Society for Biochemistry and Molecular Biology, 2007, pp. 22900–09, doi:<a href=\"https://doi.org/10.1074/jbc.M610978200\">10.1074/jbc.M610978200</a>.","ama":"Whitaker G, Angoli D, Nazzari H, Shigemoto R, Accili E. HCN2 and HCN4 isoforms self-assemble and co-assemble with equal preference to form functional pacemaker channels. <i>Journal of Biological Chemistry</i>. 2007;282(31):22900-22909. doi:<a href=\"https://doi.org/10.1074/jbc.M610978200\">10.1074/jbc.M610978200</a>","short":"G. Whitaker, D. Angoli, H. Nazzari, R. Shigemoto, E. Accili, Journal of Biological Chemistry 282 (2007) 22900–22909."},"quality_controlled":0,"title":"HCN2 and HCN4 isoforms self-assemble and co-assemble with equal preference to form functional pacemaker channels","issue":"31","volume":282,"type":"journal_article","publication":"Journal of Biological Chemistry","abstract":[{"lang":"eng","text":"Hyperpolarization-activated cyclic nucleotide-modulated (HCN) &quot;pacemaker&quot; channel subunits are integral membrane proteins that assemble as tetramers to form channels in cardiac conduction tissue and nerve cells. Previous studies have suggested that the HCN2 and HCN4 channel isoforms physically interact when overexpressed in mammalian cells, but whether they are able to co-assemble and form functional channels remains unclear. The extent to which co-assembly occurs over self-assembly and whether HCN2-HCN4 heteromeric channels are formed in native tissue are not known. In this study, we show co-assembly of HCN2 and HCN4 in live Chinese hamster ovary cells using bioluminescence resonance energy transfer (BRET2), a novel approach for studying tetramerization of ion channel subunits. Together with results from electrophysiological and imaging approaches, the BRET2 data show that HCN2 and HCN4 subunits self-assemble and co-assemble with equal preference. We also demonstrate colocalization of HCN2 and HCN4 and a positive correlation of their intensities in the embryonic mouse heart using immunohistochemistry, as well as physical interactions between these isoforms in the rat thalamus by coimmunoprecipitation. Together, these data support the formation of HCN2-HCN4 heteromeric channels in native tissue."}],"date_updated":"2021-01-12T06:58:58Z","publication_status":"published","page":"22900 - 22909","date_published":"2007-08-03T00:00:00Z","_id":"2672","month":"08","status":"public","year":"2007","intvolume":"       282","publist_id":"4225","author":[{"full_name":"Whitaker, Gina M","last_name":"Whitaker","first_name":"Gina"},{"first_name":"Damiano","last_name":"Angoli","full_name":"Angoli, Damiano"},{"full_name":"Nazzari, Hamed","first_name":"Hamed","last_name":"Nazzari"},{"first_name":"Ryuichi","last_name":"Shigemoto","orcid":"0000-0001-8761-9444","full_name":"Ryuichi Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Accili, Eric A","last_name":"Accili","first_name":"Eric"}],"extern":1,"day":"03","publisher":"American Society for Biochemistry and Molecular Biology","date_created":"2018-12-11T11:58:59Z"},{"abstract":[{"text":"Excitatory synaptic transmission is inhibited by G protein coupled receptors, including the adenosine A1, GABAB, and metabotropic glutamate receptor 7. These receptors are present in nerve terminals where they reduce the release of glutamate through activating signaling pathways negatively coupled to Ca2+ channels and adenylyl cyclase. However, it is not clear whether these receptors operate in distinct subpopulations of nerve terminals or if they are co-expressed in the same nerve terminals, despite the functional consequences that such distributions may have on synaptic transmission. Applying Ca2+ imaging and immunocytochemistry, we show that these three G protein coupled receptors coexist in a subpopulation of cerebrocortical nerve terminals. The three receptors share an intracellular signaling pathway through which their inhibitory responses are integrated and coactivation of these receptors produced an integrated response. Indeed, this response was highly variable, from a synergistic response at subthreshold agonist concentrations to an occluded response at high agonist concentrations. The presence of multiple receptors in a nerve terminal could be responsible for the physiological effects of neurotransmitter spillover from neighboring synapses or alternatively, the co-release of transmitters by the same nerve terminal.","lang":"eng"}],"publication":"Journal of Neurochemistry","date_updated":"2021-01-12T06:58:58Z","volume":103,"type":"journal_article","quality_controlled":0,"title":" The coexistence of multiple receptors in a single nerve terminal provides evidence for pre-synaptic integration","issue":"6","citation":{"mla":"Ladera, Carolina, et al. “ The Coexistence of Multiple Receptors in a Single Nerve Terminal Provides Evidence for Pre-Synaptic Integration.” <i>Journal of Neurochemistry</i>, vol. 103, no. 6, Wiley-Blackwell, 2007, pp. 2314–26, doi:<a href=\"https://doi.org/10.1111/j.1471-4159.2007.04964.x\">10.1111/j.1471-4159.2007.04964.x</a>.","short":"C. Ladera, M. Godino, R. Martín, R. Luján, R. Shigemoto, F. Ciruela, M. Torres, J. Sánchez Prieto, Journal of Neurochemistry 103 (2007) 2314–2326.","ama":"Ladera C, Godino M, Martín R, et al.  The coexistence of multiple receptors in a single nerve terminal provides evidence for pre-synaptic integration. <i>Journal of Neurochemistry</i>. 2007;103(6):2314-2326. doi:<a href=\"https://doi.org/10.1111/j.1471-4159.2007.04964.x\">10.1111/j.1471-4159.2007.04964.x</a>","apa":"Ladera, C., Godino, M., Martín, R., Luján, R., Shigemoto, R., Ciruela, F., … Sánchez Prieto, J. (2007).  The coexistence of multiple receptors in a single nerve terminal provides evidence for pre-synaptic integration. <i>Journal of Neurochemistry</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1111/j.1471-4159.2007.04964.x\">https://doi.org/10.1111/j.1471-4159.2007.04964.x</a>","chicago":"Ladera, Carolina, María Godino, Ricardo Martín, Rafael Luján, Ryuichi Shigemoto, Francisco Ciruela, Magdalena Torres, and José Sánchez Prieto. “ The Coexistence of Multiple Receptors in a Single Nerve Terminal Provides Evidence for Pre-Synaptic Integration.” <i>Journal of Neurochemistry</i>. Wiley-Blackwell, 2007. <a href=\"https://doi.org/10.1111/j.1471-4159.2007.04964.x\">https://doi.org/10.1111/j.1471-4159.2007.04964.x</a>.","ieee":"C. Ladera <i>et al.</i>, “ The coexistence of multiple receptors in a single nerve terminal provides evidence for pre-synaptic integration,” <i>Journal of Neurochemistry</i>, vol. 103, no. 6. Wiley-Blackwell, pp. 2314–2326, 2007.","ista":"Ladera C, Godino M, Martín R, Luján R, Shigemoto R, Ciruela F, Torres M, Sánchez Prieto J. 2007.  The coexistence of multiple receptors in a single nerve terminal provides evidence for pre-synaptic integration. Journal of Neurochemistry. 103(6), 2314–2326."},"doi":"10.1111/j.1471-4159.2007.04964.x","publist_id":"4224","intvolume":"       103","extern":1,"author":[{"full_name":"Ladera, Carolina","first_name":"Carolina","last_name":"Ladera"},{"last_name":"Godino","first_name":"María","full_name":"Godino, María D"},{"full_name":"Martín, Ricardo J","first_name":"Ricardo","last_name":"Martín"},{"full_name":"Luján, Rafael","last_name":"Luján","first_name":"Rafael"},{"full_name":"Ryuichi Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8761-9444","last_name":"Shigemoto","first_name":"Ryuichi"},{"full_name":"Ciruela, Francisco","last_name":"Ciruela","first_name":"Francisco"},{"last_name":"Torres","first_name":"Magdalena","full_name":"Torres, Magdalena"},{"last_name":"Sánchez Prieto","first_name":"José","full_name":"Sánchez-Prieto, José"}],"publisher":"Wiley-Blackwell","day":"01","date_created":"2018-12-11T11:58:59Z","_id":"2673","month":"12","status":"public","year":"2007","date_published":"2007-12-01T00:00:00Z","page":"2314 - 2326","publication_status":"published"},{"main_file_link":[{"open_access":"1","url":"http://arxiv.org/abs/math-ph/0510055v2"}],"date_published":"2007-03-30T00:00:00Z","editor":[{"first_name":"Fritz","last_name":"Gesztesy","full_name":"Gesztesy, Fritz"},{"full_name":"Deift, Percy","last_name":"Deift","first_name":"Percy"},{"last_name":"Galvez","first_name":"Percy","full_name":"Galvez, Percy"},{"full_name":"Perry, Peter","first_name":"Peter","last_name":"Perry"},{"last_name":"Schlag","first_name":"Wilhelm","full_name":"Schlag, Wilhelm"}],"page":"401 - 428","publication_status":"published","author":[{"last_name":"Erdös","first_name":"László","full_name":"László Erdös","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5366-9603"}],"extern":1,"publist_id":"4191","intvolume":"        76","date_created":"2018-12-11T11:59:10Z","day":"30","publisher":"American Mathematical Society","status":"public","month":"03","_id":"2705","year":"2007","title":"Recent developments in quantum mechanics with magnetic fields","quality_controlled":0,"alternative_title":["Proceedings of Symposia in Pure Mathematics"],"citation":{"mla":"Erdös, László. “Recent Developments in Quantum Mechanics with Magnetic Fields.” <i>Spectral Theory and Mathematical Physics: A Festschrift in Honor of Barry Simon’s 60th Birthday </i>, edited by Fritz Gesztesy et al., vol. 76, American Mathematical Society, 2007, pp. 401–28.","short":"L. Erdös, in:, F. Gesztesy, P. Deift, P. Galvez, P. Perry, W. Schlag (Eds.), Spectral Theory and Mathematical Physics: A Festschrift in Honor of Barry Simon’s 60th Birthday , American Mathematical Society, 2007, pp. 401–428.","ama":"Erdös L. Recent developments in quantum mechanics with magnetic fields. In: Gesztesy F, Deift P, Galvez P, Perry P, Schlag W, eds. <i>Spectral Theory and Mathematical Physics: A Festschrift in Honor of Barry Simon’s 60th Birthday </i>. Vol 76. American Mathematical Society; 2007:401-428.","apa":"Erdös, L. (2007). Recent developments in quantum mechanics with magnetic fields. In F. Gesztesy, P. Deift, P. Galvez, P. Perry, &#38; W. Schlag (Eds.), <i>Spectral Theory and Mathematical Physics: a Festschrift in Honor of Barry Simon’s 60th Birthday </i> (Vol. 76, pp. 401–428). American Mathematical Society.","chicago":"Erdös, László. “Recent Developments in Quantum Mechanics with Magnetic Fields.” In <i>Spectral Theory and Mathematical Physics: A Festschrift in Honor of Barry Simon’s 60th Birthday </i>, edited by Fritz Gesztesy, Percy Deift, Percy Galvez, Peter Perry, and Wilhelm Schlag, 76:401–28. American Mathematical Society, 2007.","ieee":"L. Erdös, “Recent developments in quantum mechanics with magnetic fields,” in <i>Spectral Theory and Mathematical Physics: a Festschrift in Honor of Barry Simon’s 60th Birthday </i>, vol. 76, F. Gesztesy, P. Deift, P. Galvez, P. Perry, and W. Schlag, Eds. American Mathematical Society, 2007, pp. 401–428.","ista":"Erdös L. 2007.Recent developments in quantum mechanics with magnetic fields. In: Spectral Theory and Mathematical Physics: a Festschrift in Honor of Barry Simon’s 60th Birthday . Proceedings of Symposia in Pure Mathematics, vol. 76, 401–428."},"publication":"Spectral Theory and Mathematical Physics: a Festschrift in Honor of Barry Simon's 60th Birthday ","date_updated":"2021-01-12T06:59:10Z","type":"book_chapter","volume":76,"oa":1},{"abstract":[{"text":"The time-dependent Gross-Pitaevskii equation describes the dynamics of initially trapped Bose-Einstein condensates. We present a rigorous proof of this fact starting from a many-body bosonic Schrödinger equation with a short-scale repulsive interaction in the dilute limit. Our proof shows the persistence of an explicit short-scale correlation structure in the condensate.","lang":"eng"}],"publication":"Physical Review Letters","date_updated":"2021-01-12T06:59:26Z","type":"journal_article","volume":98,"quality_controlled":0,"title":"Rigorous derivation of the Gross-Pitaevskii equation","issue":"4","doi":"10.1103/PhysRevLett.98.040404","citation":{"ista":"Erdös L, Schlein B, Yau H. 2007. Rigorous derivation of the Gross-Pitaevskii equation. Physical Review Letters. 98(4).","apa":"Erdös, L., Schlein, B., &#38; Yau, H. (2007). Rigorous derivation of the Gross-Pitaevskii equation. <i>Physical Review Letters</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevLett.98.040404\">https://doi.org/10.1103/PhysRevLett.98.040404</a>","chicago":"Erdös, László, Benjamin Schlein, and Horng Yau. “Rigorous Derivation of the Gross-Pitaevskii Equation.” <i>Physical Review Letters</i>. American Physical Society, 2007. <a href=\"https://doi.org/10.1103/PhysRevLett.98.040404\">https://doi.org/10.1103/PhysRevLett.98.040404</a>.","ieee":"L. Erdös, B. Schlein, and H. Yau, “Rigorous derivation of the Gross-Pitaevskii equation,” <i>Physical Review Letters</i>, vol. 98, no. 4. American Physical Society, 2007.","short":"L. Erdös, B. Schlein, H. Yau, Physical Review Letters 98 (2007).","ama":"Erdös L, Schlein B, Yau H. Rigorous derivation of the Gross-Pitaevskii equation. <i>Physical Review Letters</i>. 2007;98(4). doi:<a href=\"https://doi.org/10.1103/PhysRevLett.98.040404\">10.1103/PhysRevLett.98.040404</a>","mla":"Erdös, László, et al. “Rigorous Derivation of the Gross-Pitaevskii Equation.” <i>Physical Review Letters</i>, vol. 98, no. 4, American Physical Society, 2007, doi:<a href=\"https://doi.org/10.1103/PhysRevLett.98.040404\">10.1103/PhysRevLett.98.040404</a>."},"publist_id":"4144","intvolume":"        98","extern":1,"author":[{"last_name":"Erdös","first_name":"László","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","full_name":"László Erdös","orcid":"0000-0001-5366-9603"},{"full_name":"Schlein, Benjamin","last_name":"Schlein","first_name":"Benjamin"},{"last_name":"Yau","first_name":"Horng","full_name":"Yau, Horng-Tzer"}],"publisher":"American Physical Society","day":"26","date_created":"2018-12-11T11:59:23Z","month":"01","_id":"2748","status":"public","year":"2007","date_published":"2007-01-26T00:00:00Z","publication_status":"published"},{"date_updated":"2019-04-26T07:22:19Z","publication":"Inventiones Mathematicae","abstract":[{"text":"We prove rigorously that the one-particle density matrix of three dimensional interacting Bose systems with a short-scale repulsive pair interaction converges to the solution of the cubic non-linear Schrödinger equation in a suitable scaling limit. The result is extended to k-particle density matrices for all positive integer k. ","lang":"eng"}],"type":"review","volume":167,"issue":"3","quality_controlled":0,"title":"Derivation of the cubic non linear Schrödinger equation from quantum dynamics of many body systems","doi":"10.1007/s00222-006-0022-1","citation":{"ama":"Erdös L, Schlein B, Yau H. Derivation of the cubic non linear Schrödinger equation from quantum dynamics of many body systems. <i>Inventiones Mathematicae</i>. 2007;167(3):515-614. doi:<a href=\"https://doi.org/10.1007/s00222-006-0022-1\">10.1007/s00222-006-0022-1</a>","short":"L. Erdös, B. Schlein, H. Yau, Inventiones Mathematicae 167 (2007) 515–614.","mla":"Erdös, László, et al. “Derivation of the Cubic Non Linear Schrödinger Equation from Quantum Dynamics of Many Body Systems.” <i>Inventiones Mathematicae</i>, vol. 167, no. 3, Springer, 2007, pp. 515–614, doi:<a href=\"https://doi.org/10.1007/s00222-006-0022-1\">10.1007/s00222-006-0022-1</a>.","ista":"Erdös L, Schlein B, Yau H. 2007. Derivation of the cubic non linear Schrödinger equation from quantum dynamics of many body systems. Inventiones Mathematicae. 167(3), 515–614.","ieee":"L. Erdös, B. Schlein, and H. Yau, “Derivation of the cubic non linear Schrödinger equation from quantum dynamics of many body systems,” <i>Inventiones Mathematicae</i>, vol. 167, no. 3. Springer, pp. 515–614, 2007.","chicago":"Erdös, László, Benjamin Schlein, and Horng Yau. “Derivation of the Cubic Non Linear Schrödinger Equation from Quantum Dynamics of Many Body Systems.” <i>Inventiones Mathematicae</i>. Springer, 2007. <a href=\"https://doi.org/10.1007/s00222-006-0022-1\">https://doi.org/10.1007/s00222-006-0022-1</a>.","apa":"Erdös, L., Schlein, B., &#38; Yau, H. (2007). Derivation of the cubic non linear Schrödinger equation from quantum dynamics of many body systems. <i>Inventiones Mathematicae</i>. Springer. <a href=\"https://doi.org/10.1007/s00222-006-0022-1\">https://doi.org/10.1007/s00222-006-0022-1</a>"},"publisher":"Springer","day":"01","date_created":"2018-12-11T11:59:24Z","intvolume":"       167","publist_id":"4143","author":[{"full_name":"László Erdös","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5366-9603","last_name":"Erdös","first_name":"László"},{"first_name":"Benjamin","last_name":"Schlein","full_name":"Schlein, Benjamin"},{"last_name":"Yau","first_name":"Horng","full_name":"Yau, Horng-Tzer"}],"extern":1,"year":"2007","month":"03","_id":"2749","status":"public","date_published":"2007-03-01T00:00:00Z","page":"515 - 614","publication_status":"published"},{"author":[{"first_name":"László","last_name":"Erdös","orcid":"0000-0001-5366-9603","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","full_name":"László Erdös"},{"full_name":"Salmhofer, Manfred","first_name":"Manfred","last_name":"Salmhofer"},{"last_name":"Yau","first_name":"Horng","full_name":"Yau, Horng-Tzer"}],"extern":1,"publist_id":"4142","intvolume":"       271","date_created":"2018-12-11T11:59:24Z","day":"01","publisher":"Springer","status":"public","_id":"2750","month":"04","year":"2007","date_published":"2007-04-01T00:00:00Z","publication_status":"published","page":"1 - 53","abstract":[{"text":"We consider random Schrödinger equations on ℝd for d ≥ 3 with a homogeneous Anderson-Poisson type random potential. Denote by λ the coupling constant and ψt the solution with initial data ψ0. The space and time variables scale as χ ≃λ-2-κ/2, t ≃λ-2-κ with 0 &lt; kappa; &lt; kappa;0(d). We prove that, in the limit λ → 0, the expectation of the Wigner distribution of ψt converges weakly to the solution of a heat equation in the space variable x for arbitrary L2 initial data. The proof is based on a rigorous analysis of Feynman diagrams. In the companion paper [10] the analysis of the non-repetition diagrams was presented. In this paper we complete the proof by estimating the recollision diagrams and showing that the main terms, i.e. the ladder diagrams with renormalized propagator, converge to the heat equation.","lang":"eng"}],"publication":"Communications in Mathematical Physics","date_updated":"2021-01-12T06:59:27Z","volume":271,"type":"journal_article","title":"Quantum diffusion of the random Schrödinger evolution in the scaling limit II. The recollision diagrams","quality_controlled":0,"issue":"1","doi":"10.1007/s00220-006-0158-2","citation":{"apa":"Erdös, L., Salmhofer, M., &#38; Yau, H. (2007). Quantum diffusion of the random Schrödinger evolution in the scaling limit II. The recollision diagrams. <i>Communications in Mathematical Physics</i>. Springer. <a href=\"https://doi.org/10.1007/s00220-006-0158-2\">https://doi.org/10.1007/s00220-006-0158-2</a>","ieee":"L. Erdös, M. Salmhofer, and H. Yau, “Quantum diffusion of the random Schrödinger evolution in the scaling limit II. The recollision diagrams,” <i>Communications in Mathematical Physics</i>, vol. 271, no. 1. Springer, pp. 1–53, 2007.","chicago":"Erdös, László, Manfred Salmhofer, and Horng Yau. “Quantum Diffusion of the Random Schrödinger Evolution in the Scaling Limit II. The Recollision Diagrams.” <i>Communications in Mathematical Physics</i>. Springer, 2007. <a href=\"https://doi.org/10.1007/s00220-006-0158-2\">https://doi.org/10.1007/s00220-006-0158-2</a>.","ista":"Erdös L, Salmhofer M, Yau H. 2007. Quantum diffusion of the random Schrödinger evolution in the scaling limit II. The recollision diagrams. Communications in Mathematical Physics. 271(1), 1–53.","mla":"Erdös, László, et al. “Quantum Diffusion of the Random Schrödinger Evolution in the Scaling Limit II. The Recollision Diagrams.” <i>Communications in Mathematical Physics</i>, vol. 271, no. 1, Springer, 2007, pp. 1–53, doi:<a href=\"https://doi.org/10.1007/s00220-006-0158-2\">10.1007/s00220-006-0158-2</a>.","short":"L. Erdös, M. Salmhofer, H. Yau, Communications in Mathematical Physics 271 (2007) 1–53.","ama":"Erdös L, Salmhofer M, Yau H. Quantum diffusion of the random Schrödinger evolution in the scaling limit II. The recollision diagrams. <i>Communications in Mathematical Physics</i>. 2007;271(1):1-53. doi:<a href=\"https://doi.org/10.1007/s00220-006-0158-2\">10.1007/s00220-006-0158-2</a>"}},{"page":"621 - 685","publication_status":"published","date_published":"2007-07-01T00:00:00Z","year":"2007","month":"07","_id":"2751","status":"public","publisher":"Birkhäuser","day":"01","date_created":"2018-12-11T11:59:24Z","intvolume":"         8","publist_id":"4141","extern":1,"author":[{"orcid":"0000-0001-5366-9603","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","full_name":"László Erdös","first_name":"László","last_name":"Erdös"},{"full_name":"Salmhofer, Manfred","first_name":"Manfred","last_name":"Salmhofer"},{"full_name":"Yau, Horng-Tzer","last_name":"Yau","first_name":"Horng"}],"citation":{"mla":"Erdös, László, et al. “Quantum Diffusion for the Anderson Model in the Scaling Limit.” <i>Annales Henri Poincare</i>, vol. 8, no. 4, Birkhäuser, 2007, pp. 621–85, doi:<a href=\"https://doi.org/10.1007/s00023-006-0318-0\">10.1007/s00023-006-0318-0</a>.","short":"L. Erdös, M. Salmhofer, H. Yau, Annales Henri Poincare 8 (2007) 621–685.","ama":"Erdös L, Salmhofer M, Yau H. Quantum diffusion for the Anderson model in the scaling limit. <i>Annales Henri Poincare</i>. 2007;8(4):621-685. doi:<a href=\"https://doi.org/10.1007/s00023-006-0318-0\">10.1007/s00023-006-0318-0</a>","apa":"Erdös, L., Salmhofer, M., &#38; Yau, H. (2007). Quantum diffusion for the Anderson model in the scaling limit. <i>Annales Henri Poincare</i>. Birkhäuser. <a href=\"https://doi.org/10.1007/s00023-006-0318-0\">https://doi.org/10.1007/s00023-006-0318-0</a>","ieee":"L. Erdös, M. Salmhofer, and H. Yau, “Quantum diffusion for the Anderson model in the scaling limit,” <i>Annales Henri Poincare</i>, vol. 8, no. 4. Birkhäuser, pp. 621–685, 2007.","chicago":"Erdös, László, Manfred Salmhofer, and Horng Yau. “Quantum Diffusion for the Anderson Model in the Scaling Limit.” <i>Annales Henri Poincare</i>. Birkhäuser, 2007. <a href=\"https://doi.org/10.1007/s00023-006-0318-0\">https://doi.org/10.1007/s00023-006-0318-0</a>.","ista":"Erdös L, Salmhofer M, Yau H. 2007. Quantum diffusion for the Anderson model in the scaling limit. Annales Henri Poincare. 8(4), 621–685."},"doi":"10.1007/s00023-006-0318-0","issue":"4","quality_controlled":0,"title":"Quantum diffusion for the Anderson model in the scaling limit","volume":8,"type":"journal_article","date_updated":"2021-01-12T06:59:27Z","publication":"Annales Henri Poincare","abstract":[{"lang":"eng","text":"We consider random Schrödinger equations on ℤd for d ≥ 3 with identically distributed random potential. Denote by λ the coupling constant and ψ t the solution with initial data ψ 0. The space and time variables scale as x ∼ λ -2-κ/2,t ∼ λ-2-κ with 0 &lt; κ &lt; κ0(d). We prove that, in the limit λ → 0, the expectation of the Wigner distribution of ψ t converges weakly to a solution of a heat equation in the space variable x for arbitrary L 2 initial data. The diffusion coefficient is uniquely determined by the kinetic energy associated to the momentum υ. This work is an extension to the lattice case of our previous result in the continuum [8,9]. Due to the non-convexity of the level surfaces of the dispersion relation, the estimates of several Feynman graphs are more involved."}]},{"_id":"2752","month":"01","status":"public","year":"2007","intvolume":"       257","publist_id":"4140","extern":1,"author":[{"orcid":"0000-0001-5366-9603","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","full_name":"László Erdös","first_name":"László","last_name":"Erdös"},{"full_name":"Salmhofer, Manfred","first_name":"Manfred","last_name":"Salmhofer"}],"day":"01","publisher":"Springer","date_created":"2018-12-11T11:59:25Z","page":"261 - 294","publication_status":"published","date_published":"2007-01-01T00:00:00Z","type":"journal_article","volume":257,"publication":"Mathematische Zeitschrift","abstract":[{"text":"We prove L p -bounds on the Fourier transform of measures μ supported on two dimensional surfaces. Our method allows to consider surfaces whose Gauss curvature vanishes on a one-dimensional submanifold. Under a certain non-degeneracy condition, we prove that μ ∧ ε L 4+β, β &gt; 0, and we give a logarithmically divergent bound on the L 4-norm. We use this latter bound to estimate almost singular integrals involving the dispersion relation, e(p)= ∑13 [1-\\cos p_j]} , of the discrete Laplace operator on the cubic lattice. We briefly explain our motivation for this bound originating in the theory of random Schrödinger operators.","lang":"eng"}],"date_updated":"2021-01-12T06:59:28Z","citation":{"ista":"Erdös L, Salmhofer M. 2007. Decay of the Fourier transform of surfaces with vanishing curvature. Mathematische Zeitschrift. 257(2), 261–294.","ieee":"L. Erdös and M. Salmhofer, “Decay of the Fourier transform of surfaces with vanishing curvature,” <i>Mathematische Zeitschrift</i>, vol. 257, no. 2. Springer, pp. 261–294, 2007.","chicago":"Erdös, László, and Manfred Salmhofer. “Decay of the Fourier Transform of Surfaces with Vanishing Curvature.” <i>Mathematische Zeitschrift</i>. Springer, 2007. <a href=\"https://doi.org/10.1007/s00209-007-0125-4\">https://doi.org/10.1007/s00209-007-0125-4</a>.","apa":"Erdös, L., &#38; Salmhofer, M. (2007). Decay of the Fourier transform of surfaces with vanishing curvature. <i>Mathematische Zeitschrift</i>. Springer. <a href=\"https://doi.org/10.1007/s00209-007-0125-4\">https://doi.org/10.1007/s00209-007-0125-4</a>","ama":"Erdös L, Salmhofer M. Decay of the Fourier transform of surfaces with vanishing curvature. <i>Mathematische Zeitschrift</i>. 2007;257(2):261-294. doi:<a href=\"https://doi.org/10.1007/s00209-007-0125-4\">10.1007/s00209-007-0125-4</a>","short":"L. Erdös, M. Salmhofer, Mathematische Zeitschrift 257 (2007) 261–294.","mla":"Erdös, László, and Manfred Salmhofer. “Decay of the Fourier Transform of Surfaces with Vanishing Curvature.” <i>Mathematische Zeitschrift</i>, vol. 257, no. 2, Springer, 2007, pp. 261–94, doi:<a href=\"https://doi.org/10.1007/s00209-007-0125-4\">10.1007/s00209-007-0125-4</a>."},"doi":"10.1007/s00209-007-0125-4","quality_controlled":0,"title":"Decay of the Fourier transform of surfaces with vanishing curvature","issue":"2"},{"quality_controlled":0,"title":"Turbulence transition in pipe flow","doi":"10.1146/annurev.fluid.39.050905.110308","citation":{"ama":"Eckhardt B, Schneider T, Hof B, Westerweel J. Turbulence transition in pipe flow. <i>Annual Review of Fluid Mechanics</i>. 2007;39:447-468. doi:<a href=\"https://doi.org/10.1146/annurev.fluid.39.050905.110308\">10.1146/annurev.fluid.39.050905.110308</a>","short":"B. Eckhardt, T. Schneider, B. Hof, J. Westerweel, Annual Review of Fluid Mechanics 39 (2007) 447–468.","mla":"Eckhardt, Bruno, et al. “Turbulence Transition in Pipe Flow.” <i>Annual Review of Fluid Mechanics</i>, vol. 39, Annual Reviews, 2007, pp. 447–68, doi:<a href=\"https://doi.org/10.1146/annurev.fluid.39.050905.110308\">10.1146/annurev.fluid.39.050905.110308</a>.","ista":"Eckhardt B, Schneider T, Hof B, Westerweel J. 2007. Turbulence transition in pipe flow. Annual Review of Fluid Mechanics. 39, 447–468.","chicago":"Eckhardt, Bruno, Tobias Schneider, Björn Hof, and Jerry Westerweel. “Turbulence Transition in Pipe Flow.” <i>Annual Review of Fluid Mechanics</i>. Annual Reviews, 2007. <a href=\"https://doi.org/10.1146/annurev.fluid.39.050905.110308\">https://doi.org/10.1146/annurev.fluid.39.050905.110308</a>.","ieee":"B. Eckhardt, T. Schneider, B. Hof, and J. Westerweel, “Turbulence transition in pipe flow,” <i>Annual Review of Fluid Mechanics</i>, vol. 39. Annual Reviews, pp. 447–468, 2007.","apa":"Eckhardt, B., Schneider, T., Hof, B., &#38; Westerweel, J. (2007). Turbulence transition in pipe flow. <i>Annual Review of Fluid Mechanics</i>. Annual Reviews. <a href=\"https://doi.org/10.1146/annurev.fluid.39.050905.110308\">https://doi.org/10.1146/annurev.fluid.39.050905.110308</a>"},"abstract":[{"lang":"eng","text":"Pipe flow is a prominent example among the shear flows that undergo transition to turbulence without mediation by a linear instability of the laminar profile. Experiments on pipe flow, as well as plane Couette and plane Poiseuille flow, show that triggering turbulence depends sensitively on initial conditions, that between the laminar and the turbulent states there exists no intermediate state with simple spatial or temporal characteristics, and that turbulence is not persistent, i.e., it can decay again, if the observation time is long enough. All these features can consistently be explained on the assumption that the turbulent state corresponds to a chaotic saddle in state space. The goal of this review is to explain this concept, summarize the numerical and experimental evidence for pipe flow, and outline the consequences for related flows."}],"publication":"Annual Review of Fluid Mechanics","date_updated":"2019-04-26T07:22:20Z","volume":39,"type":"review","date_published":"2007-01-01T00:00:00Z","publication_status":"published","page":"447 - 468","intvolume":"        39","publist_id":"4096","author":[{"last_name":"Eckhardt","first_name":"Bruno","full_name":"Eckhardt, Bruno"},{"first_name":"Tobias","last_name":"Schneider","full_name":"Schneider, Tobias M"},{"full_name":"Björn Hof","id":"3A374330-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-2057-2754","last_name":"Hof","first_name":"Björn"},{"full_name":"Westerweel, Jerry","last_name":"Westerweel","first_name":"Jerry"}],"extern":1,"day":"01","publisher":"Annual Reviews","date_created":"2018-12-11T11:59:38Z","_id":"2793","month":"01","status":"public","year":"2007"},{"date_updated":"2021-01-12T06:59:45Z","volume":117,"type":"conference","title":"Lifetime of turbulence in pipe flow","quality_controlled":0,"conference":{"name":"EETC11: European Turbulence Conference"},"alternative_title":["Springer Proceedings in Physics"],"citation":{"ama":"Hof B, Tax W, Westerweel J. Lifetime of turbulence in pipe flow. In: Vol 117. Springer; 2007:556-558. doi:<a href=\"https://doi.org/10.1007/978-3-540-72604-3_177\">10.1007/978-3-540-72604-3_177</a>","short":"B. Hof, W. Tax, J. Westerweel, in:, Springer, 2007, pp. 556–558.","mla":"Hof, Björn, et al. <i>Lifetime of Turbulence in Pipe Flow</i>. Vol. 117, Springer, 2007, pp. 556–58, doi:<a href=\"https://doi.org/10.1007/978-3-540-72604-3_177\">10.1007/978-3-540-72604-3_177</a>.","ista":"Hof B, Tax W, Westerweel J. 2007. Lifetime of turbulence in pipe flow. EETC11: European Turbulence Conference, Springer Proceedings in Physics, vol. 117, 556–558.","chicago":"Hof, Björn, Wilco Tax, and Jerry Westerweel. “Lifetime of Turbulence in Pipe Flow,” 117:556–58. Springer, 2007. <a href=\"https://doi.org/10.1007/978-3-540-72604-3_177\">https://doi.org/10.1007/978-3-540-72604-3_177</a>.","ieee":"B. Hof, W. Tax, and J. Westerweel, “Lifetime of turbulence in pipe flow,” presented at the EETC11: European Turbulence Conference, 2007, vol. 117, pp. 556–558.","apa":"Hof, B., Tax, W., &#38; Westerweel, J. (2007). Lifetime of turbulence in pipe flow (Vol. 117, pp. 556–558). Presented at the EETC11: European Turbulence Conference, Springer. <a href=\"https://doi.org/10.1007/978-3-540-72604-3_177\">https://doi.org/10.1007/978-3-540-72604-3_177</a>"},"doi":"10.1007/978-3-540-72604-3_177","author":[{"id":"3A374330-F248-11E8-B48F-1D18A9856A87","full_name":"Björn Hof","orcid":"0000-0003-2057-2754","last_name":"Hof","first_name":"Björn"},{"last_name":"Tax","first_name":"Wilco","full_name":"Tax, Wilco"},{"first_name":"Jerry","last_name":"Westerweel","full_name":"Westerweel, Jerry"}],"extern":1,"intvolume":"       117","publist_id":"4095","date_created":"2018-12-11T11:59:38Z","publisher":"Springer","day":"01","status":"public","month":"06","_id":"2794","year":"2007","date_published":"2007-06-01T00:00:00Z","publication_status":"published","page":"556 - 558"}]