@inbook{5940,
  author       = {Juhás, Gabriel and Kazlov, Igor and Juhásová, Ana},
  booktitle    = {Applications and Theory of Petri Nets},
  isbn         = {9783642136740},
  issn         = {0302-9743},
  pages        = {1--17},
  publisher    = {Springer Berlin Heidelberg},
  title        = {{Instance Deadlock: A Mystery behind Frozen Programs}},
  doi          = {10.1007/978-3-642-13675-7_1},
  year         = {2010},
}

@article{598,
  abstract     = {It is not well understood how the human Mediator complex, transcription factor IIH and RNA polymerase II (Pol II) work together with activators to initiate transcription. Activator binding alters Mediator structure, yet the functional consequences of such structural shifts remain unknown. The p53 C terminus and its activation domain interact with different Mediator subunits, and we find that each interaction differentially affects Mediator structure; strikingly, distinct p53-Mediator structures differentially affect Pol II activity. Only the p53 activation domain induces the formation of a large pocket domain at the Mediator-Pol II interaction site, and this correlates with activation of stalled Pol II to a productively elongating state. Moreover, we define a Mediator requirement for TFIIH-dependent Pol II C-terminal domain phosphorylation and identify substantial differences in Pol II C-terminal domain processing that correspond to distinct p53-Mediator structural states. Our results define a fundamental mechanism by which p53 activates transcription and suggest that Mediator structural shifts trigger activation of stalled Pol II complexes.},
  author       = {Meyer, Krista and Lin, Shih and Bernecky, Carrie A and Gao, Yuefeng and Taatjes, Dylan},
  journal      = {Nature Structural and Molecular Biology},
  number       = {6},
  pages        = {753 -- 760},
  publisher    = {Nature Publishing Group},
  title        = {{P53 activates transcription by directing structural shifts in Mediator}},
  doi          = {10.1038/nsmb.1816},
  volume       = {17},
  year         = {2010},
}

@article{6142,
  abstract     = {Defining the mutational landscape when individuals of a species grow separately and diverge over many generations can provide insights into trait evolution. A specific example of this involves studying changes associated with domestication where different lines of the same wild stock have been cultivated independently in different standard environments. Whole genome sequence comparison of such lines permits estimation of mutation rates, inference of genes' ancestral states and ancestry of existing strains, and correction of sequencing errors in genome databases. Here we study domestication of the C. elegans Bristol strain as a model, and report the genome sequence of LSJ1 (Bristol), a sibling of the standard C. elegans reference wild type N2 (Bristol). The LSJ1 and N2 lines were cultivated separately from shortly after the Bristol strain was isolated until methods to freeze C. elegans were developed. We find that during this time the two strains have accumulated 1208 genetic differences. We describe phenotypic variation between N2 and LSJ1 in the rate at which embryos develop, the rate of production of eggs, the maturity of eggs at laying, and feeding behavior, all the result of post-isolation changes. We infer the ancestral alleles in the original Bristol isolate and highlight 2038 likely sequencing errors in the original N2 reference genome sequence. Many of these changes modify genome annotation. Our study provides a starting point to further investigate genotype-phenotype association and offers insights into the process of selection as a result of laboratory domestication.},
  author       = {Weber, Katherine P. and De, Subhajyoti and Kozarewa, Iwanka and Turner, Daniel J. and Babu, M. Madan and de Bono, Mario},
  issn         = {1932-6203},
  journal      = {PLoS ONE},
  number       = {11},
  publisher    = {Public Library of Science},
  title        = {{Whole genome sequencing highlights genetic changes associated with laboratory domestication of C. elegans}},
  doi          = {10.1371/journal.pone.0013922},
  volume       = {5},
  year         = {2010},
}

@inbook{619,
  abstract     = {Sinclair Ross’s novel As for Me and My House has long since been canonized as Canadian prairie fiction. Accordingly, it has been the subject of many critical studies and academic papers. Most commentators have concentrated on such literary issues as the representation of the western landscape or the reliability of the female narrator. But so far little consideration has been given to the social and cultural implications of the novel. Few attempts have been made to analyze the text from a cultural perspective including such social markers as class, gender and ethnicity. That is all the more surprising because Sinclair Ross has often been credited for being a realistic author and As for Me and My House has often been interpreted as a regional novel characteristic of a particular time and place.},
  author       = {Zacharasiewicz, Waldemar and Kirsch, Fritz Peter},
  booktitle    = {Social and cultural interaction and literary landscapes in the Canadian West : impressions of an exploratory field trip and academic interaction in the Canadian West : Rapports interculturels et paysages littéraires dans l'Ouest canadien},
  pages        = {173 -- 179},
  publisher    = {Facultas.WUV},
  title        = {{“This is a fundamentalist town”: The Prairie Town as a Site of Social and Cultural Conflict in Sinclair Ross’s As for Me and My House}},
  year         = {2010},
}

@article{6198,
  abstract     = {Stroke is a major public health problem leading to high rates of death and disability in adults. Excessive stimulation of N-methyl-D-aspartate receptors (NMDARs) and the resulting neuronal nitric oxide synthase (nNOS) activation are crucial for neuronal injury after stroke insult. However, directly inhibiting NMDARs or nNOS can cause severe side effects because they have key physiological functions in the CNS. Here we show that cerebral ischemia induces the interaction of nNOS with postsynaptic density protein-95 (PSD-95). Disrupting nNOS-PSD-95 interaction via overexpressing the N-terminal amino acid residues 1-133 of nNOS (nNOS-N(1-133)) prevented glutamate-induced excitotoxicity and cerebral ischemic damage. Given the mechanism of nNOS-PSD-95 interaction, we developed a series of compounds and discovered a small-molecular inhibitor of the nNOS-PSD-95 interaction, ZL006. This drug blocked the ischemia-induced nNOS-PSD-95 association selectively, had potent neuroprotective activity in vitro and ameliorated focal cerebral ischemic damage in mice and rats subjected to middle cerebral artery occlusion (MCAO) and reperfusion. Moreover, it readily crossed the blood-brain barrier, did not inhibit NMDAR function, catalytic activity of nNOS or spatial memory, and had no effect on aggressive behaviors. Thus, this new drug may serve as a treatment for stroke, perhaps without major side effects. },
  author       = {Zhou, L and Li, F and Xu, Haibing and Luo, CX and Wu, HY and Zhu, MM and Lu, W and Ji, X and Zhou, QG and Zhu, DY},
  issn         = {1078-8956},
  journal      = {Nature Medicine},
  number       = {12},
  pages        = {1439--1443},
  publisher    = {Nature Publishing Group},
  title        = {{Treatment of cerebral ischemia by disrupting ischemia-induced interaction of nNOS with PSD-95}},
  doi          = {10.1038/nm.2245},
  volume       = {16},
  year         = {2010},
}

@article{2071,
  abstract     = {The X or Z chromosome has several characteristics that distinguish it from the autosomes, namely hemizygosity in the heterogametic sex, and a potentially different effective population size, both of which may influence the rate and nature of evolution. In particular, there may be an accelerated rate of adaptive change for X-linked compared to autosomal coding sequences, often referred to as the Faster-X effect. Empirical studies have indicated that the strength of Faster-X evolution varies among different species, and theoretical treatments have shown that demography and mating system can substantially affect the degree of Faster-X evolution. Here we integrate genomic data on Faster-X evolution from a variety of animals with the demographic factors, mating system, and sex chromosome regulatory characteristics that may influence it. Our results suggest that differences in effective population size and mechanisms of dosage compensation may influence the perceived extent of Faster-X evolution, and help to explain several clade-specific patterns that we observe.},
  author       = {Mank, Judith E and Beatriz Vicoso and Berlin, Sofia and Charlesworth, Brian},
  journal      = {Evolution},
  number       = {3},
  pages        = {663 -- 674},
  publisher    = {Wiley-Blackwell},
  title        = {{Effective population size and the Faster-X effect: Empirical results and their interpretation}},
  doi          = {10.1111/j.1558-5646.2009.00853.x},
  volume       = {64},
  year         = {2010},
}

@phdthesis{2075,
  abstract     = {This thesis investigates the combination of data-driven and physically based techniques for acquiring, modeling, and animating deformable materials, with a special focus on human faces. Furthermore, based on these techniques, we introduce a data-driven process for designing and fabricating materials with desired deformation behavior. 
Realistic simulation behavior, surface details, and appearance are still demanding tasks. Neither pure data-driven, pure procedural, nor pure physical methods are best suited for accurate synthesis of facial motion and details (both for appearance and geometry), due to the difficulties in model design, parameter estimation, and desired controllability for animators. Capturing of a small but representative amount of real data, and then synthesizing diverse on-demand examples with physically-based models and real data as input benefits from both sides: Highly realistic model behavior due to real-world data and controllability due to physically-based models.
To model the face and its behavior, hybrid physically-based and data-driven approaches are elaborated. We investigate surface-based representations as well as a solid representation based on FEM. To achieve realistic behavior, we propose to build light-weighted data capture devices to acquire real-world data to estimate model parameters and to employ concepts from data-driven modeling techniques and machine learning. The resulting models support simple acquisition systems, offer techniques to process and extract model parameters from real-world data, provide a compact representation of the facial geometry and its motion, and allow intuitive editing. We demonstrate applications such as capture of facial geometry and motion and real-time animation and transfer of facial details, and show that our soft tissue model can react to external forces and produce realistic deformations beyond facial expressions.
Based on this model, we furthermore introduce a data-driven process for designing and fabricating materials with desired deformation behavior. The process starts with measuring deformation properties of base materials. Each material is represented as a non-linear stress-strain relationship in a finite-element model. For material design and fabrication, we introduce an optimization process that finds the best combination of base materials that meets a user’s criteria specified by example deformations. Our algorithm employs a number of strategies to prune poor solutions from the combinatorial search space. We finally demonstrate the complete process by designing and fabricating objects with complex heterogeneous materials using modern multi-material 3D printers.
},
  author       = {Bernd Bickel},
  booktitle    = {Unknown},
  number       = {7458},
  publisher    = {Unknown},
  title        = {{Measurement-based modeling and fabrication of deformable materials for human faces}},
  doi          = {dx.doi.org/10.3929/ethz-a-006354908},
  volume       = {499},
  year         = {2010},
}

@article{10127,
  abstract     = {We use numerical simulations to show how noninteracting hard particles binding to a deformable elastic shell may self-assemble into a variety of linear patterns. This is a result of the nontrivial elastic response to deformations of shells. The morphology of the patterns can be controlled by the mechanical properties of the surface, and can be fine-tuned by varying the binding energy of the particles. We also repeat our calculations for a fully flexible chain and find that the chain conformations follow patterns similar to those formed by the nanoparticles under analogous conditions. We propose a simple way of understanding and sorting the different structures and relate it to the underlying shape transition of the shell. Finally, we discuss the implications of our results.},
  author       = {Šarić, Anđela and Cacciuto, Angelo},
  issn         = {1744-683X},
  journal      = {Soft Matter},
  keywords     = {condensed matter physics, general chemistry},
  number       = {5},
  pages        = {1874--1878},
  publisher    = {Royal Society of Chemistry (RSC)},
  title        = {{Particle self-assembly on soft elastic shells}},
  doi          = {10.1039/c0sm01143f},
  volume       = {7},
  year         = {2010},
}

@article{10128,
  abstract     = {An extensive computational study of the conformational preferences of three capped dipeptides: Ac-Xxx-Phe-NH2, Xxx = Gly, Ala, Val is reported. On the basis of local second-order Møller–Plesset perturbation theory (LMP2) and DFT computations we were able to identify the experimentally observed conformers as γL–γL(g−) and β-turn I(g+) in Ac-Gly-Phe-NH2, and Ac-Ala-Phe-NH2, and as the closely related γL(g+)–γL(g−) and β-turn I(a,g+) in Ac-Val-Phe-NH2. In contrast to the experimental observation that peptides with bulky side chain have a propensity for β-turns, we show that in Ac-Val-Phe-NH2 the minimum energy structure corresponds to the experimentally non detected β-strand.},
  author       = {Šarić, Anđela and Hrenar, T. and Mališ, M. and Došlić, N.},
  issn         = {1463-9076},
  journal      = {Physical Chemistry Chemical Physics},
  keywords     = {Physical and Theoretical Chemistry, General Physics and Astronomy},
  number       = {18},
  pages        = {4678--4685},
  publisher    = {Royal Society of Chemistry },
  title        = {{Quantum mechanical study of secondary structure formation in protected dipeptides}},
  doi          = {10.1039/b923041f},
  volume       = {12},
  year         = {2010},
}

@article{10390,
  abstract     = {We use numerical simulations to study the phase behavior of a system of purely repulsive soft dumbbells as a function of size ratio of the two components and their relative degree of deformability. We find a plethora of different phases, which includes most of the mesophases observed in self-assembly of block copolymers but also crystalline structures formed by asymmetric, hard binary mixtures. Our results detail the phenomenological behavior of these systems when softness is introduced in terms of two different classes of interparticle interactions: (a) the elastic Hertz potential, which has a finite energy cost for complete overlap of any two components, and (b) a generic power-law repulsion with tunable exponent. We discuss how simple geometric arguments can be used to account for the large structural variety observed in these systems and detail the similarities and differences in the phase behavior for the two classes of potentials under consideration.},
  author       = {Šarić, Anđela and Bozorgui, Behnaz and Cacciuto, Angelo},
  issn         = {1520-5207},
  journal      = {The Journal of Physical Chemistry B},
  keywords     = {materials chemistry},
  number       = {22},
  pages        = {7182--7189},
  publisher    = {American Chemical Society},
  title        = {{Packing of soft asymmetric dumbbells}},
  doi          = {10.1021/jp107545w},
  volume       = {115},
  year         = {2010},
}

@article{10391,
  abstract     = {We use numerical simulations to show how a fully flexible filament binding to a deformable cylindrical surface may acquire a macroscopic persistence length and a helical conformation. This is a result of the nontrivial elastic response to deformations of elastic sheets. We find that the filament’s helical pitch is completely determined by the mechanical properties of the surface, and can be easily tuned by varying the surface stretching rigidity. We propose simple scaling arguments to understand the physical mechanism behind this phenomenon and present a phase diagram indicating under what conditions one should expect a fully flexible chain to behave as a helical semiflexible filament. Finally, we discuss the implications of our results.},
  author       = {Šarić, Anđela and Pàmies, Josep C. and Cacciuto, Angelo},
  issn         = {1079-7114},
  journal      = {Physical Review Letters},
  keywords     = {general physics and astronomy},
  number       = {22},
  publisher    = {American Physical Society},
  title        = {{Effective elasticity of a flexible filament bound to a deformable cylindrical surface}},
  doi          = {10.1103/physrevlett.104.226101},
  volume       = {104},
  year         = {2010},
}

@inproceedings{1042,
  abstract     = {Recent years have seen tremendous progress in the field of cold and ultracold molecules. A central goal in the field is currently the realization of stable rovibronic ground-state molecular samples in the regime of quantum degeneracy, e.g. in the form of molecular Bose-Einstein condensates, molecular degenerate Fermi gases, or, when an optical lattice is present, molecular Mott-insulator phases. However, molecular samples are not readily cooled to the extremely low temperatures at which quantum degeneracy occurs. In particular, laser cooling, the \'workhorse\' for the field of atomic quantum gases, is generally not applicable to molecular samples. Here we take an important step beyond previous work1 and provide details on the realization of an ultracold quantum gas of ground-state dimer molecules trapped in an optical lattice as recently reported in Ref. 2. We demonstrate full control over all internal and external quantum degrees of freedom for the ground-state molecules by deterministically preparing the molecules in a single quantum state, i.e. in a specific hyperfine sublevel of the rovibronic ground state, while the molecules are trapped in the motional ground state of the individual lattice wells. We circumvent the problem of cooling by associating weakly-bound molecules out of a zero-temperature atomic Mott-insulator state and by transferring these to the absolute ground state in a four-photon STIRAP process. Our preparation procedure directly leads to a long-lived, lattice-trapped molecular many-body state, which we expect to form the platform for many of the envisioned future experiments with molecular quantum gases, e.g. on precision molecular spectroscopy, quantum information science, and dipolar quantum systems.},
  author       = {Danzl, Johann G and Mark, Manfred and Haller, Elmar and Gustavsson, Mattias and Hart, Russell and Nägerl, Hanns},
  pages        = {256 -- 269},
  publisher    = {World Scientific Publishing},
  title        = {{Production of a quantum gas of rovibronic ground-state molecules in an optical lattice}},
  doi          = {10.1142/9789814282345_0024},
  year         = {2010},
}

@article{1044,
  abstract     = {Control over all internal and external degrees of freedom of molecules at the level of single quantum states will enable a series of fundamental studies in physics and chemistry1,2. In particular, samples of ground-state molecules at ultralow temperatures and high number densities will facilitate new quantum-gas studies3 and future applications in quantum information science4. However, high phase-space densities for molecular samples are not readily attainable because efficient cooling techniques such as laser cooling are lacking. Here we produce an ultracold and dense sample of molecules in a single hyperfine level of the rovibronic ground state with each molecule individually trapped in the motional ground state of an optical lattice well. Starting from a zero-temperature atomic Mott-insulator state with optimized double-site occupancy6, weakly bound dimer molecules are efficiently associated on a Feshbach resonance7 and subsequently transferred to the rovibronic ground state by a stimulated four-photon process with >50% efficiency. The molecules are trapped in the lattice and have a lifetime of 8 s. Our results present a crucial step towards Bose-Einstein condensation of ground-state molecules and, when suitably generalized to polar heteronuclear molecules, the realization of dipolar quantum-gas phases in optical lattices8-10.},
  author       = {Danzl, Johann G and Mark, Manfred and Haller, Elmar and Gustavsson, Mattias and Hart, Russell and Aldegunde, Jesus and Hutson, Jeremy and Nägerl, Hanns},
  journal      = {Nature Physics},
  number       = {4},
  pages        = {265 -- 270},
  publisher    = {Nature Publishing Group},
  title        = {{An ultracold high-density sample of rovibronic ground-state molecules in an optical lattice}},
  doi          = {10.1038/nphys1533},
  volume       = {6},
  year         = {2010},
}

@article{1045,
  abstract     = {We report on the observation of confinement-induced resonances in strongly interacting quantum-gas systems with tunable interactions for one- and two-dimensional geometry. Atom-atom scattering is substantially modified when the s-wave scattering length approaches the length scale associated with the tight transversal confinement, leading to characteristic loss and heating signatures. Upon introducing an anisotropy for the transversal confinement we observe a splitting of the confinement-induced resonance. With increasing anisotropy additional resonances appear. In the limit of a two-dimensional system we find that one resonance persists.},
  author       = {Haller, Elmar and Mark, Manfred and Hart, Russell and Danzl, Johann G and Reichsöllner, Lukas and Melezhik, Vladimir and Schmelcher, Peter and Nägerl, Hanns},
  journal      = {Physical Review Letters},
  number       = {15},
  publisher    = {American Physical Society},
  title        = {{Confinement-induced resonances in low-dimensional quantum systems}},
  doi          = {10.1103/PhysRevLett.104.153203},
  volume       = {104},
  year         = {2010},
}

@article{1046,
  abstract     = {The phenomenon of matter-wave interference lies at the heart of quantum physics. It has been observed in various contexts in the limit of non-interacting particles as a single-particle effect. Here we observe and control matter-wave interference whose evolution is driven by interparticle interactions. In a multi-path matter-wave interferometer, the macroscopic manybody wave function of an interacting atomic Bose-Einstein condensate develops a regular interference pattern, allowing us to detect and directly visualize the effect of interaction-induced phase shifts. We demonstrate control over the phase evolution by inhibiting interaction-induced dephasing and by refocusing a dephased macroscopic matter wave in a spin-echo-type experiment. Our results show that interactions in a many-body system lead to a surprisingly coherent evolution, possibly enabling narrow-band and high-brightness matterwave interferometers based on atom lasers.},
  author       = {Gustavsson, Mattias and Haller, Elmar and Mark, Manfred and Danzl, Johann G and Hart, Russell and Daley, Andrew and Nägerl, Hanns},
  journal      = {New Journal of Physics},
  publisher    = {IOP Publishing Ltd.},
  title        = {{Interference of interacting matter waves}},
  doi          = {10.1088/1367-2630/12/6/065029},
  volume       = {12},
  year         = {2010},
}

@article{1047,
  abstract     = {Particles in a perfect lattice potential perform Bloch oscillations when subject to a constant force, leading to localization and preventing conductivity. For a weakly interacting Bose-Einstein condensate of Cs atoms, we observe giant center-of-mass oscillations in position space with a displacement across hundreds of lattice sites when we add a periodic modulation to the force near the Bloch frequency. We study the dependence of these "super" Bloch oscillations on lattice depth, modulation amplitude, and modulation frequency and show that they provide a means to induce linear transport in a dissipation-free lattice.},
  author       = {Haller, Elmar and Hart, Russell and Mark, Manfred and Danzl, Johann G and Reichsöllner, Lukas and Nägerl, Hanns},
  journal      = {Physical Review Letters},
  number       = {20},
  publisher    = {American Physical Society},
  title        = {{Inducing transport in a dissipation-free lattice with super bloch oscillations}},
  doi          = {10.1103/PhysRevLett.104.200403},
  volume       = {104},
  year         = {2010},
}

@article{1049,
  abstract     = {Quantum many-body systems can have phase transitions even at zero temperature; fluctuations arising from Heisenbergĝ€™s uncertainty principle, as opposed to thermal effects, drive the system from one phase to another. Typically, during the transition the relative strength of two competing terms in the systemĝ€™s Hamiltonian changes across a finite critical value. A well-known example is the Mottĝ€" Hubbard quantum phase transition from a superfluid to an insulating phase, which has been observed for weakly interacting bosonic atomic gases. However, for strongly interacting quantum systems confined to lower-dimensional geometry, a novel type of quantum phase transition may be induced and driven by an arbitrarily weak perturbation to the Hamiltonian. Here we observe such an effectĝ€"the sineĝ€"Gordon quantum phase transition from a superfluid Luttinger liquid to a Mott insulatorĝ€ "in a one-dimensional quantum gas of bosonic caesium atoms with tunable interactions. For sufficiently strong interactions, the transition is induced by adding an arbitrarily weak optical lattice commensurate with the atomic granularity, which leads to immediate pinning of the atoms. We map out the phase diagram and find that our measurements in the strongly interacting regime agree well with a quantum field description based on the exactly solvable sineĝ€"Gordon model. We trace the phase boundary all the way to the weakly interacting regime, where we find good agreement with the predictions of the one-dimensional Boseĝ€"Hubbard model. Our results open up the experimental study of quantum phase transitions, criticality and transport phenomena beyond Hubbard-type models in the context of ultracold gases.},
  author       = {Haller, Elmar and Hart, Russell and Mark, Manfred and Danzl, Johann G and Reichsöllner, Lukas and Gustavsson, Mattias and Dalmonte, Marcello and Pupillo, Guido and Nägerl, Hanns},
  journal      = {Nature},
  number       = {7306},
  pages        = {597 -- 600},
  publisher    = {Nature Publishing Group},
  title        = {{Pinning quantum phase transition for a Luttinger liquid of strongly interacting bosons}},
  doi          = {10.1038/nature09259},
  volume       = {466},
  year         = {2010},
}

@inproceedings{758,
  abstract     = {Set agreement [4] is a fundamental problem in distributed computing, in which processes collectively choose a small subset of values from a larger set of proposals. Set agreement has been extensively studied in both synchronous and asynchronous systems [10,11,3,5,8,9]. Real world distributed systems, however, are neither purely synchronous nor purely asynchronous. To describe such a system, Dwork et al. [6] introduced the idea of partial synchrony. They assume for every execution some (unknown) time GST (global stabilization time), after which the system is synchronous. In a recent paper [1,2], we study the complexity of set agreement in the context of partially synchronous systems, determining the minimum-sized window of synchrony in which set agreement can be solved. We show that at least ⌊t/k⌋ + 2 synchronous rounds are required for k-set agreement, where t < n is the number of crashes, and k is the agreement parameter of the set agreement task. We then introduce an algorithm that terminates in any window of synchrony of size at least ⌊t/k⌋ + 4 rounds. Together, these results tightly bound the inherent price of tolerating some asynchrony.},
  author       = {Alistarh, Dan-Adrian and Gilbert, Seth and Guerraoui, Rachid and Travers, Corentin},
  pages        = {404 -- 405},
  publisher    = {Springer},
  title        = {{Brief announcement: New bounds for partially synchronous set agreement}},
  doi          = {10.1007/978-3-642-15763-9_40},
  volume       = {6343 LNCS},
  year         = {2010},
}

@article{7703,
  abstract     = {By combining gene expression profiling with image registration, Tomer et al. (2010) find that the mushroom body of the segmented worm Platynereis dumerilii shares many features with the mammalian cerebral cortex. The authors propose that the mushroom body and cortex evolved from the same structure in the common ancestor of vertebrates and invertebrates.},
  author       = {Sweeney, Lora Beatrice Jaeger and Luo, Liqun},
  issn         = {0092-8674},
  journal      = {Cell},
  number       = {5},
  pages        = {679--681},
  publisher    = {Elsevier},
  title        = {{‘Fore brain: A hint of the ancestral cortex}},
  doi          = {10.1016/j.cell.2010.08.024},
  volume       = {142},
  year         = {2010},
}

@article{8472,
  abstract     = {Characterization of protein dynamics by solid-state NMR spectroscopy requires robust and accurate measurement protocols, which are not yet fully developed. In this study, we investigate the backbone dynamics of microcrystalline ubiquitin using different approaches. A rotational-echo double-resonance type (REDOR-type) methodology allows one to accurately measure 1H−15N order parameters in highly deuterated samples. We show that the systematic errors in the REDOR experiment are as low as 1% or even less, giving access to accurate data for the amplitudes of backbone mobility. Combining such dipolar-coupling-derived order parameters with autocorrelated and cross-correlated 15N relaxation rates, we are able to quantitate amplitudes and correlation times of backbone dynamics on picosecond and nanosecond time scales in a residue-resolved manner. While the mobility on picosecond time scales appears to have rather uniform amplitude throughout the protein, we unambiguously identify and quantitate nanosecond mobility with order parameters S2 as low as 0.8 in some regions of the protein, where nanosecond dynamics has also been revealed in solution state. The methodology used here, a combination of accurate dipolar-coupling measurements and different relaxation parameters, yields details about dynamics on different time scales and can be applied to solid protein samples such as amyloid fibrils or membrane proteins.},
  author       = {Schanda, Paul and Meier, Beat H. and Ernst, Matthias},
  issn         = {0002-7863},
  journal      = {Journal of the American Chemical Society},
  number       = {45},
  pages        = {15957--15967},
  publisher    = {American Chemical Society},
  title        = {{Quantitative analysis of protein backbone dynamics in microcrystalline ubiquitin by solid-state NMR spectroscopy}},
  doi          = {10.1021/ja100726a},
  volume       = {132},
  year         = {2010},
}