[{"author":[{"full_name":"Riedl, Julia","last_name":"Riedl","first_name":"Julia"},{"first_name":"Kevin","last_name":"Flynn","full_name":"Flynn, Kevin C"},{"full_name":"Raducanu, Aurelia","last_name":"Raducanu","first_name":"Aurelia"},{"last_name":"Gärtner","orcid":"0000-0001-6120-3723","first_name":"Florian R","full_name":"Florian Gärtner","id":"397A88EE-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Beck, Gisela","first_name":"Gisela","last_name":"Beck"},{"full_name":"Bosl, Michael","last_name":"Bosl","first_name":"Michael"},{"full_name":"Bradke, Frank","first_name":"Frank","last_name":"Bradke"},{"last_name":"Massberg","first_name":"Steffen","full_name":"Massberg, Steffen"},{"full_name":"Aszodi, Attila","last_name":"Aszodi","first_name":"Attila"},{"first_name":"Michael K","last_name":"Sixt","orcid":"0000-0002-6620-9179","full_name":"Michael Sixt","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Wedlich-Söldner, Roland","last_name":"Wedlich Söldner","first_name":"Roland"}],"year":"2010","publication_status":"published","date_updated":"2021-01-12T07:53:28Z","date_published":"2010-03-01T00:00:00Z","title":"Lifeact mice for studying F-actin dynamics","page":"168 - 169","day":"01","type":"journal_article","issue":"3","status":"public","publication":"Nature Methods","month":"03","quality_controlled":0,"publist_id":"2171","_id":"3957","extern":1,"volume":7,"publisher":"Nature Publishing Group","date_created":"2018-12-11T12:06:06Z","doi":"10.1038/nmeth0310-168","intvolume":"         7","citation":{"ista":"Riedl J, Flynn K, Raducanu A, Gärtner FR, Beck G, Bosl M, Bradke F, Massberg S, Aszodi A, Sixt MK, Wedlich Söldner R. 2010. Lifeact mice for studying F-actin dynamics. Nature Methods. 7(3), 168–169.","apa":"Riedl, J., Flynn, K., Raducanu, A., Gärtner, F. R., Beck, G., Bosl, M., … Wedlich Söldner, R. (2010). Lifeact mice for studying F-actin dynamics. <i>Nature Methods</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/nmeth0310-168\">https://doi.org/10.1038/nmeth0310-168</a>","ama":"Riedl J, Flynn K, Raducanu A, et al. Lifeact mice for studying F-actin dynamics. <i>Nature Methods</i>. 2010;7(3):168-169. doi:<a href=\"https://doi.org/10.1038/nmeth0310-168\">10.1038/nmeth0310-168</a>","mla":"Riedl, Julia, et al. “Lifeact Mice for Studying F-Actin Dynamics.” <i>Nature Methods</i>, vol. 7, no. 3, Nature Publishing Group, 2010, pp. 168–69, doi:<a href=\"https://doi.org/10.1038/nmeth0310-168\">10.1038/nmeth0310-168</a>.","ieee":"J. Riedl <i>et al.</i>, “Lifeact mice for studying F-actin dynamics,” <i>Nature Methods</i>, vol. 7, no. 3. Nature Publishing Group, pp. 168–169, 2010.","short":"J. Riedl, K. Flynn, A. Raducanu, F.R. Gärtner, G. Beck, M. Bosl, F. Bradke, S. Massberg, A. Aszodi, M.K. Sixt, R. Wedlich Söldner, Nature Methods 7 (2010) 168–169.","chicago":"Riedl, Julia, Kevin Flynn, Aurelia Raducanu, Florian R Gärtner, Gisela Beck, Michael Bosl, Frank Bradke, et al. “Lifeact Mice for Studying F-Actin Dynamics.” <i>Nature Methods</i>. Nature Publishing Group, 2010. <a href=\"https://doi.org/10.1038/nmeth0310-168\">https://doi.org/10.1038/nmeth0310-168</a>."}},{"abstract":[{"lang":"eng","text":"Extracellular matrix (ECM) proteins can modify immune reactions, e.g. by sequestering or displaying growth factors and by interacting with immune and glial cells. Here we quantified by quantitative polymerase chain reaction (qPCR) expression of 50 ECM components and 34 ECM degrading enzymes in multiple sclerosis (MS) active and inactive white matter lesions. COL1A1, COL3A1, COL5A1 and COL5A2 chains were induced strongly in active lesions and even more in inactive lesions. These chains interact to form collagen types I, III and V, which are fibrillar collagens. Biglycan and decorin, which can decorate fibrillar collagens, were also induced strongly. The fibrillar collagens, biglycan and decorin were largely found between the endothelium and astrocytic glia limitans in the perivascular space where they formed a meshwork which was closely associated with infiltrating immune cells. In active lesions collagen V was also seen in the heavily infiltrated parenchyma. Fibrillar collagens I and III inhibited in vitro human monocyte production of CCL2 (MCP-1), an inflammatory chemokine involved in recruitment of immune cells. Together, ECM changes in lesions with different activities were quantified and proteins forming a perivascular fibrosis were identified. Induced fibrillar collagens may contribute to limiting enlargement of MS lesions by inhibiting the production of CCL2 by monocytes."}],"date_created":"2018-12-11T12:06:07Z","publisher":"Wiley-Blackwell","volume":20,"citation":{"short":"H. Mohan, M. Krumbholz, R. Sharma, S. Eisele, A. Junker, M.K. Sixt, J. Newcombe, H. Wekerle, R. Hohlfeld, H. Lassmann, E. Meinl, Brain Pathology 20 (2010) 966–975.","chicago":"Mohan, Hema, Markus Krumbholz, Rakhi Sharma, Sylvia Eisele, Andreas Junker, Michael K Sixt, Jia Newcombe, et al. “Extracellular Matrix in Multiple Sclerosis Lesions: Fibrillar Collagens, Biglycan and Decorin Are Upregulated and Associated with Infiltrating Immune Cells.” <i>Brain Pathology</i>. Wiley-Blackwell, 2010. <a href=\"https://doi.org/10.1111/j.1750-3639.2010.00399.x\">https://doi.org/10.1111/j.1750-3639.2010.00399.x</a>.","ista":"Mohan H, Krumbholz M, Sharma R, Eisele S, Junker A, Sixt MK, Newcombe J, Wekerle H, Hohlfeld R, Lassmann H, Meinl E. 2010. Extracellular matrix in multiple sclerosis lesions: fibrillar collagens, biglycan and decorin are upregulated and associated with infiltrating immune cells. Brain Pathology. 20(5), 966–975.","apa":"Mohan, H., Krumbholz, M., Sharma, R., Eisele, S., Junker, A., Sixt, M. K., … Meinl, E. (2010). Extracellular matrix in multiple sclerosis lesions: fibrillar collagens, biglycan and decorin are upregulated and associated with infiltrating immune cells. <i>Brain Pathology</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1111/j.1750-3639.2010.00399.x\">https://doi.org/10.1111/j.1750-3639.2010.00399.x</a>","ama":"Mohan H, Krumbholz M, Sharma R, et al. Extracellular matrix in multiple sclerosis lesions: fibrillar collagens, biglycan and decorin are upregulated and associated with infiltrating immune cells. <i>Brain Pathology</i>. 2010;20(5):966-975. doi:<a href=\"https://doi.org/10.1111/j.1750-3639.2010.00399.x\">10.1111/j.1750-3639.2010.00399.x</a>","mla":"Mohan, Hema, et al. “Extracellular Matrix in Multiple Sclerosis Lesions: Fibrillar Collagens, Biglycan and Decorin Are Upregulated and Associated with Infiltrating Immune Cells.” <i>Brain Pathology</i>, vol. 20, no. 5, Wiley-Blackwell, 2010, pp. 966–75, doi:<a href=\"https://doi.org/10.1111/j.1750-3639.2010.00399.x\">10.1111/j.1750-3639.2010.00399.x</a>.","ieee":"H. Mohan <i>et al.</i>, “Extracellular matrix in multiple sclerosis lesions: fibrillar collagens, biglycan and decorin are upregulated and associated with infiltrating immune cells,” <i>Brain Pathology</i>, vol. 20, no. 5. Wiley-Blackwell, pp. 966–975, 2010."},"doi":"10.1111/j.1750-3639.2010.00399.x","intvolume":"        20","issue":"5","extern":1,"_id":"3958","publist_id":"2169","quality_controlled":0,"status":"public","publication":"Brain Pathology","month":"09","day":"01","page":"966 - 975","type":"journal_article","publication_status":"published","year":"2010","author":[{"full_name":"Mohan, Hema","last_name":"Mohan","first_name":"Hema"},{"last_name":"Krumbholz","first_name":"Markus","full_name":"Krumbholz, Markus"},{"full_name":"Sharma, Rakhi","first_name":"Rakhi","last_name":"Sharma"},{"first_name":"Sylvia","last_name":"Eisele","full_name":"Eisele, Sylvia"},{"first_name":"Andreas","last_name":"Junker","full_name":"Junker, Andreas"},{"last_name":"Sixt","orcid":"0000-0002-6620-9179","first_name":"Michael K","full_name":"Michael Sixt","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Newcombe, Jia","first_name":"Jia","last_name":"Newcombe"},{"first_name":"Hartmut","last_name":"Wekerle","full_name":"Wekerle, Hartmut"},{"first_name":"Reinhard","last_name":"Hohlfeld","full_name":"Hohlfeld, Reinhard"},{"full_name":"Lassmann, Hans","last_name":"Lassmann","first_name":"Hans"},{"first_name":"Edgar","last_name":"Meinl","full_name":"Meinl, Edgar"}],"title":"Extracellular matrix in multiple sclerosis lesions: fibrillar collagens, biglycan and decorin are upregulated and associated with infiltrating immune cells","date_updated":"2021-01-12T07:53:28Z","date_published":"2010-09-01T00:00:00Z"},{"date_updated":"2021-01-12T07:53:29Z","date_published":"2010-05-28T00:00:00Z","title":"Immobilized chemokine fields and soluble chemokine gradients cooperatively shape migration patterns of dendritic cells","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"full_name":"Schumann, Kathrin","id":"F44D762E-4F9D-11E9-B64C-9EB26CEFFB5F","last_name":"Schumann","first_name":"Kathrin"},{"first_name":"Tim","last_name":"Lämmermann","full_name":"Lämmermann, Tim"},{"first_name":"Markus","last_name":"Bruckner","full_name":"Bruckner, Markus"},{"first_name":"Daniel","last_name":"Legler","full_name":"Legler, Daniel"},{"last_name":"Polleux","first_name":"Julien","full_name":"Polleux, Julien"},{"full_name":"Spatz, Joachim","first_name":"Joachim","last_name":"Spatz"},{"last_name":"Schuler","first_name":"Gerold","full_name":"Schuler, Gerold"},{"full_name":"Förster, Reinhold","last_name":"Förster","first_name":"Reinhold"},{"first_name":"Manfred","last_name":"Lutz","full_name":"Lutz, Manfred"},{"full_name":"Sorokin, Lydia","last_name":"Sorokin","first_name":"Lydia"},{"last_name":"Sixt","orcid":"0000-0002-6620-9179","first_name":"Michael K","full_name":"Sixt, Michael K","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87"}],"year":"2010","publication_status":"published","type":"journal_article","page":"703 - 713","day":"28","status":"public","oa_version":"None","month":"05","publication":"Immunity","publist_id":"2168","extern":"1","_id":"3959","issue":"5","intvolume":"        32","doi":"10.1016/j.immuni.2010.04.017","citation":{"short":"K. Schumann, T. Lämmermann, M. Bruckner, D. Legler, J. Polleux, J. Spatz, G. Schuler, R. Förster, M. Lutz, L. Sorokin, M.K. Sixt, Immunity 32 (2010) 703–713.","chicago":"Schumann, Kathrin, Tim Lämmermann, Markus Bruckner, Daniel Legler, Julien Polleux, Joachim Spatz, Gerold Schuler, et al. “Immobilized Chemokine Fields and Soluble Chemokine Gradients Cooperatively Shape Migration Patterns of Dendritic Cells.” <i>Immunity</i>. Cell Press, 2010. <a href=\"https://doi.org/10.1016/j.immuni.2010.04.017\">https://doi.org/10.1016/j.immuni.2010.04.017</a>.","apa":"Schumann, K., Lämmermann, T., Bruckner, M., Legler, D., Polleux, J., Spatz, J., … Sixt, M. K. (2010). Immobilized chemokine fields and soluble chemokine gradients cooperatively shape migration patterns of dendritic cells. <i>Immunity</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.immuni.2010.04.017\">https://doi.org/10.1016/j.immuni.2010.04.017</a>","ista":"Schumann K, Lämmermann T, Bruckner M, Legler D, Polleux J, Spatz J, Schuler G, Förster R, Lutz M, Sorokin L, Sixt MK. 2010. Immobilized chemokine fields and soluble chemokine gradients cooperatively shape migration patterns of dendritic cells. Immunity. 32(5), 703–713.","ama":"Schumann K, Lämmermann T, Bruckner M, et al. Immobilized chemokine fields and soluble chemokine gradients cooperatively shape migration patterns of dendritic cells. <i>Immunity</i>. 2010;32(5):703-713. doi:<a href=\"https://doi.org/10.1016/j.immuni.2010.04.017\">10.1016/j.immuni.2010.04.017</a>","ieee":"K. Schumann <i>et al.</i>, “Immobilized chemokine fields and soluble chemokine gradients cooperatively shape migration patterns of dendritic cells,” <i>Immunity</i>, vol. 32, no. 5. Cell Press, pp. 703–713, 2010.","mla":"Schumann, Kathrin, et al. “Immobilized Chemokine Fields and Soluble Chemokine Gradients Cooperatively Shape Migration Patterns of Dendritic Cells.” <i>Immunity</i>, vol. 32, no. 5, Cell Press, 2010, pp. 703–13, doi:<a href=\"https://doi.org/10.1016/j.immuni.2010.04.017\">10.1016/j.immuni.2010.04.017</a>."},"language":[{"iso":"eng"}],"volume":32,"publisher":"Cell Press","date_created":"2018-12-11T12:06:07Z","abstract":[{"text":"Chemokines orchestrate immune cell trafficking by eliciting either directed or random migration and by activating integrins in order to induce cell adhesion. Analyzing dendritic cell (DC) migration, we showed that these distinct cellular responses depended on the mode of chemokine presentation within tissues. The surface-immobilized form of the chemokine CCL21, the heparan sulfate-anchoring ligand of the CC-chemokine receptor 7 (CCR7), caused random movement of DCs that was confined to the chemokine-presenting surface because it triggered integrin-mediated adhesion. Upon direct contact with CCL21, DCs truncated the anchoring residues of CCL21, thereby releasing it from the solid phase. Soluble CCL21 functionally resembles the second CCR7 ligand, CCL19, which lacks anchoring residues and forms soluble gradients. Both soluble CCR7 ligands triggered chemotactic movement, but not surface adhesion. Adhesive random migration and directional steering cooperate to produce dynamic but spatially restricted locomotion patterns closely resembling the cellular dynamics observed in secondary lymphoid organs.","lang":"eng"}]},{"issue":"17","publication":"EMBO Journal","quality_controlled":0,"month":"09","status":"public","main_file_link":[{"open_access":"1","url":"http://www.ncbi.nlm.nih.gov/pmc/issues/190105/"}],"extern":1,"_id":"3960","publist_id":"2167","publisher":"Wiley-Blackwell","volume":29,"abstract":[{"lang":"eng","text":"When lymphocytes follow chemotactic cues, they can adopt different migratory modes depending on the geometry and molecular composition of their extracellular environment. In this issue of The EMBO Journal, Klemke et al (2010) describe a novel Ras-dependent chemokine receptor signalling pathway that leads to activation of cofilin, which in turn amplifies actin turnover. This signalling module is exclusively required for lymphocyte migration in three-dimensional (3D) environments, but not for locomotion on two-dimensional (2D) surfaces."}],"date_created":"2018-12-11T12:06:07Z","citation":{"ieee":"M. Weber and M. K. Sixt, “MEK signalling tunes actin treadmilling for interstitial lymphocyte migration,” <i>EMBO Journal</i>, vol. 29, no. 17. Wiley-Blackwell, pp. 2861–2863, 2010.","mla":"Weber, Michele, and Michael K. Sixt. “MEK Signalling Tunes Actin Treadmilling for Interstitial Lymphocyte Migration.” <i>EMBO Journal</i>, vol. 29, no. 17, Wiley-Blackwell, 2010, pp. 2861–63, doi:<a href=\"https://doi.org/10.1038/emboj.2010.183\">10.1038/emboj.2010.183</a>.","ama":"Weber M, Sixt MK. MEK signalling tunes actin treadmilling for interstitial lymphocyte migration. <i>EMBO Journal</i>. 2010;29(17):2861-2863. doi:<a href=\"https://doi.org/10.1038/emboj.2010.183\">10.1038/emboj.2010.183</a>","apa":"Weber, M., &#38; Sixt, M. K. (2010). MEK signalling tunes actin treadmilling for interstitial lymphocyte migration. <i>EMBO Journal</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1038/emboj.2010.183\">https://doi.org/10.1038/emboj.2010.183</a>","ista":"Weber M, Sixt MK. 2010. MEK signalling tunes actin treadmilling for interstitial lymphocyte migration. EMBO Journal. 29(17), 2861–2863.","chicago":"Weber, Michele, and Michael K Sixt. “MEK Signalling Tunes Actin Treadmilling for Interstitial Lymphocyte Migration.” <i>EMBO Journal</i>. Wiley-Blackwell, 2010. <a href=\"https://doi.org/10.1038/emboj.2010.183\">https://doi.org/10.1038/emboj.2010.183</a>.","short":"M. Weber, M.K. Sixt, EMBO Journal 29 (2010) 2861–2863."},"intvolume":"        29","doi":"10.1038/emboj.2010.183","author":[{"id":"3A3FC708-F248-11E8-B48F-1D18A9856A87","full_name":"Michele Weber","first_name":"Michele","last_name":"Weber"},{"first_name":"Michael K","orcid":"0000-0002-6620-9179","last_name":"Sixt","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","full_name":"Michael Sixt"}],"publication_status":"published","year":"2010","title":"MEK signalling tunes actin treadmilling for interstitial lymphocyte migration","date_updated":"2021-01-12T07:53:29Z","date_published":"2010-09-01T00:00:00Z","page":"2861 - 2863","day":"01","oa":1,"type":"journal_article"},{"abstract":[{"text":"For innate and adaptive immune responses it is essential that inflammatory cells use quick and flexible locomotion strategies. Accordingly, most leukocytes can efficiently infiltrate and traverse almost every physiological or artificial environment. Here, we review how leukocytes might achieve this task mechanistically, and summarize recent findings on the principles of cytoskeletal force generation and transduction at the leading edge of leukocytes. We propose a model in which the cells switch between adhesion-receptor-mediated force transmission and locomotion modes that are based on cellular deformations, but independent of adhesion receptors. This plasticity in migration strategies allows leukocytes to adapt to the geometry and molecular composition of their environment.","lang":"eng"}],"date_created":"2018-12-11T12:06:08Z","publisher":"Wiley-Blackwell","volume":11,"intvolume":"        11","doi":"10.1038/embor.2010.147","citation":{"mla":"Renkawitz, Jörg, and Michael K. Sixt. “Mechanisms of Force Generation and Force Transmission during Interstitial Leukocyte Migration.” <i>EMBO Reports</i>, vol. 11, no. 10, Wiley-Blackwell, 2010, pp. 744–50, doi:<a href=\"https://doi.org/10.1038/embor.2010.147\">10.1038/embor.2010.147</a>.","ieee":"J. Renkawitz and M. K. Sixt, “Mechanisms of force generation and force transmission during interstitial leukocyte migration,” <i>EMBO Reports</i>, vol. 11, no. 10. Wiley-Blackwell, pp. 744–750, 2010.","ama":"Renkawitz J, Sixt MK. Mechanisms of force generation and force transmission during interstitial leukocyte migration. <i>EMBO Reports</i>. 2010;11(10):744-750. doi:<a href=\"https://doi.org/10.1038/embor.2010.147\">10.1038/embor.2010.147</a>","ista":"Renkawitz J, Sixt MK. 2010. Mechanisms of force generation and force transmission during interstitial leukocyte migration. EMBO Reports. 11(10), 744–750.","apa":"Renkawitz, J., &#38; Sixt, M. K. (2010). Mechanisms of force generation and force transmission during interstitial leukocyte migration. <i>EMBO Reports</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1038/embor.2010.147\">https://doi.org/10.1038/embor.2010.147</a>","chicago":"Renkawitz, Jörg, and Michael K Sixt. “Mechanisms of Force Generation and Force Transmission during Interstitial Leukocyte Migration.” <i>EMBO Reports</i>. Wiley-Blackwell, 2010. <a href=\"https://doi.org/10.1038/embor.2010.147\">https://doi.org/10.1038/embor.2010.147</a>.","short":"J. Renkawitz, M.K. Sixt, EMBO Reports 11 (2010) 744–750."},"issue":"10","extern":1,"_id":"3961","publist_id":"2166","month":"09","publication":"EMBO Reports","status":"public","quality_controlled":0,"day":"24","acknowledgement":"We are grateful to Michele Weber for critical comments on the manuscript. Work in the laboratory of M.S. is supported by the German Research Foundation, the Peter Hans Hofschneider Foundation for Experimental Biomedicine and the Max Planck Society. J.R. is supported by a PhD fellowship of the Böhringer Ingelheim Fond. We thank Reinhard Fässler and Stefan Jentsch for their continuous support.","page":"744 - 750","type":"journal_article","publication_status":"published","year":"2010","author":[{"id":"3F0587C8-F248-11E8-B48F-1D18A9856A87","full_name":"Jörg Renkawitz","first_name":"Jörg","orcid":"0000-0003-2856-3369","last_name":"Renkawitz"},{"id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","full_name":"Michael Sixt","first_name":"Michael K","orcid":"0000-0002-6620-9179","last_name":"Sixt"}],"title":"Mechanisms of force generation and force transmission during interstitial leukocyte migration","date_updated":"2021-01-12T07:53:30Z","date_published":"2010-09-24T00:00:00Z"},{"day":"01","publication_identifier":{"issn":["2663-337X"]},"OA_place":"publisher","type":"dissertation","author":[{"last_name":"Pflicke","first_name":"Holger","full_name":"Pflicke, Holger","id":"CAA57A9A-5B61-11E9-B130-E0C1E1F2C83D"}],"publication_status":"published","year":"2010","article_processing_charge":"No","title":"Dendritic cell migration across basement membranes in the skin","date_published":"2010-07-01T00:00:00Z","date_updated":"2026-04-09T14:37:07Z","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","publisher":"Institute of Science and Technology Austria","department":[{"_id":"CaHe"},{"_id":"GradSch"}],"date_created":"2018-12-11T12:06:08Z","alternative_title":["ISTA Thesis"],"citation":{"ista":"Pflicke H. 2010.   Dendritic cell migration across basement membranes in the skin. Institute of Science and Technology Austria.","ama":"Pflicke H.   Dendritic cell migration across basement membranes in the skin. 2010.","apa":"Pflicke, H. (2010). <i>  Dendritic cell migration across basement membranes in the skin</i>. Institute of Science and Technology Austria.","ieee":"H. Pflicke, “  Dendritic cell migration across basement membranes in the skin,” Institute of Science and Technology Austria, 2010.","mla":"Pflicke, Holger. <i>  Dendritic Cell Migration across Basement Membranes in the Skin</i>. Institute of Science and Technology Austria, 2010.","short":"H. Pflicke,   Dendritic Cell Migration across Basement Membranes in the Skin, Institute of Science and Technology Austria, 2010.","chicago":"Pflicke, Holger. “  Dendritic Cell Migration across Basement Membranes in the Skin.” Institute of Science and Technology Austria, 2010."},"language":[{"iso":"eng"}],"supervisor":[{"first_name":"Carl-Philipp J","orcid":"0000-0002-0912-4566","last_name":"Heisenberg","id":"39427864-F248-11E8-B48F-1D18A9856A87","full_name":"Heisenberg, Carl-Philipp J"}],"degree_awarded":"PhD","month":"07","corr_author":"1","oa_version":"None","status":"public","_id":"3962","publist_id":"2165"},{"publication_status":"published","article_processing_charge":"No","year":"2010","author":[{"full_name":"Streinzer, M.","first_name":"M.","last_name":"Streinzer"},{"id":"3153D6D4-F248-11E8-B48F-1D18A9856A87","full_name":"Ellis, Thomas","orcid":"0000-0002-8511-0254","last_name":"Ellis","first_name":"Thomas"},{"full_name":"Paulus, H.","last_name":"Paulus","first_name":"H."},{"last_name":"Spaethe","first_name":"J.","full_name":"Spaethe, J."}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Visual discrimination between two sexually deceptive Ophrys species by a bee pollinator","date_published":"2010-01-01T00:00:00Z","date_updated":"2021-01-12T07:53:30Z","day":"01","page":"141 - 148","type":"journal_article","license":"https://creativecommons.org/licenses/by-nc/4.0/","issue":"3","extern":"1","_id":"3963","publist_id":"2164","oa_version":"None","status":"public","month":"01","publication":"Arthropod-Plant Interactions","abstract":[{"text":"Almost all species of the orchid genus Ophrys are pollinated by sexual deception. The orchids mimic the sex pheromone of receptive female insects, mainly hymenopterans, in order to attract males seeking to copulate. Most Ophrys species have achromatic flowers, but some exhibit a coloured perianth and a bright, conspicuous labellum pattern. We recently showed that the pink perianth of Ophrys heldreichii flowers increases detectability by its pollinator, males of the long-horned bee Eucera berlandi. Here we tested the hypothesis that the bright, complex labellum pattern mimics the female of the pollinator to increase attractiveness toward males. In a dual-choice test we offered E. berlandi males an O. heldreichii flower and a flower from O. dictynnae, which also exhibits a pinkish perianth but no conspicuous labellum pattern. Both flowers were housed in UV-transmitting acrylic glass boxes to exclude olfactory signals. Males significantly preferred O. heldreichii to O. dictynnae flowers. In a second experiment, we replaced the perianth of both flowers with identical artificial perianths made from pink card, so that only the labellum differed between the two flower stimuli. Males then chose between both stimuli at random, suggesting that the presence of a labellum pattern does not affect their choice. Spectral measurements revealed higher colour contrast with the background of the perianth of O. heldreichii compared to O. dictynnae, but no difference in green receptor-specific contrast or brightness. Our results show that male choice is guided by the chromatic contrast of the perianth during the initial flower approach but is not affected by the presence of a labellum pattern. Instead, we hypothesise that the labellum pattern is involved in aversive learning during post-copulatory behaviour and used by the orchid as a strategy to increase outcrossing.","lang":"eng"}],"date_created":"2018-12-11T12:06:08Z","publisher":"Springer","volume":4,"language":[{"iso":"eng"}],"tmp":{"image":"/images/cc_by_nc.png","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","short":"CC BY-NC (4.0)"},"citation":{"chicago":"Streinzer, M., Thomas Ellis, H. Paulus, and J. Spaethe. “Visual Discrimination between Two Sexually Deceptive Ophrys Species by a Bee Pollinator.” <i>Arthropod-Plant Interactions</i>. Springer, 2010. <a href=\"https://doi.org/10.1007/s11829-010-9093-4\">https://doi.org/10.1007/s11829-010-9093-4</a>.","short":"M. Streinzer, T. Ellis, H. Paulus, J. Spaethe, Arthropod-Plant Interactions 4 (2010) 141–148.","ieee":"M. Streinzer, T. Ellis, H. Paulus, and J. Spaethe, “Visual discrimination between two sexually deceptive Ophrys species by a bee pollinator,” <i>Arthropod-Plant Interactions</i>, vol. 4, no. 3. Springer, pp. 141–148, 2010.","mla":"Streinzer, M., et al. “Visual Discrimination between Two Sexually Deceptive Ophrys Species by a Bee Pollinator.” <i>Arthropod-Plant Interactions</i>, vol. 4, no. 3, Springer, 2010, pp. 141–48, doi:<a href=\"https://doi.org/10.1007/s11829-010-9093-4\">10.1007/s11829-010-9093-4</a>.","ista":"Streinzer M, Ellis T, Paulus H, Spaethe J. 2010. Visual discrimination between two sexually deceptive Ophrys species by a bee pollinator. Arthropod-Plant Interactions. 4(3), 141–148.","apa":"Streinzer, M., Ellis, T., Paulus, H., &#38; Spaethe, J. (2010). Visual discrimination between two sexually deceptive Ophrys species by a bee pollinator. <i>Arthropod-Plant Interactions</i>. Springer. <a href=\"https://doi.org/10.1007/s11829-010-9093-4\">https://doi.org/10.1007/s11829-010-9093-4</a>","ama":"Streinzer M, Ellis T, Paulus H, Spaethe J. Visual discrimination between two sexually deceptive Ophrys species by a bee pollinator. <i>Arthropod-Plant Interactions</i>. 2010;4(3):141-148. doi:<a href=\"https://doi.org/10.1007/s11829-010-9093-4\">10.1007/s11829-010-9093-4</a>"},"doi":"10.1007/s11829-010-9093-4","intvolume":"         4"},{"page":"127 - 139","day":"28","acknowledgement":"This research is partially supported by the Defense Advanced Research Projects Agency (DARPA) under grants HR0011-05-1-0007 and HR0011-05-1-0057 and by CNRS under grant PICS-3416.","type":"journal_article","author":[{"full_name":"Cohen-Steiner, David","first_name":"David","last_name":"Cohen Steiner"},{"full_name":"Herbert Edelsbrunner","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","first_name":"Herbert","last_name":"Edelsbrunner","orcid":"0000-0002-9823-6833"},{"full_name":"Harer, John","last_name":"Harer","first_name":"John"},{"full_name":"Mileyko, Yuriy","first_name":"Yuriy","last_name":"Mileyko"}],"publication_status":"published","year":"2010","title":"Lipschitz functions have L_p-stable persistence","date_updated":"2021-01-12T07:53:31Z","date_published":"2010-01-28T00:00:00Z","publisher":"Springer","volume":10,"abstract":[{"lang":"eng","text":"We prove two stability results for Lipschitz functions on triangulable, compact metric spaces and consider applications of both to problems in systems biology. Given two functions, the first result is formulated in terms of the Wasserstein distance between their persistence diagrams and the second in terms of their total persistence."}],"date_created":"2018-12-11T12:06:09Z","doi":"10.1007/s10208-010-9060-6","citation":{"short":"D. Cohen Steiner, H. Edelsbrunner, J. Harer, Y. Mileyko, Foundations of Computational Mathematics 10 (2010) 127–139.","chicago":"Cohen Steiner, David, Herbert Edelsbrunner, John Harer, and Yuriy Mileyko. “Lipschitz Functions Have L_p-Stable Persistence.” <i>Foundations of Computational Mathematics</i>. Springer, 2010. <a href=\"https://doi.org/10.1007/s10208-010-9060-6\">https://doi.org/10.1007/s10208-010-9060-6</a>.","ama":"Cohen Steiner D, Edelsbrunner H, Harer J, Mileyko Y. Lipschitz functions have L_p-stable persistence. <i>Foundations of Computational Mathematics</i>. 2010;10(2):127-139. doi:<a href=\"https://doi.org/10.1007/s10208-010-9060-6\">10.1007/s10208-010-9060-6</a>","ista":"Cohen Steiner D, Edelsbrunner H, Harer J, Mileyko Y. 2010. Lipschitz functions have L_p-stable persistence. Foundations of Computational Mathematics. 10(2), 127–139.","apa":"Cohen Steiner, D., Edelsbrunner, H., Harer, J., &#38; Mileyko, Y. (2010). Lipschitz functions have L_p-stable persistence. <i>Foundations of Computational Mathematics</i>. Springer. <a href=\"https://doi.org/10.1007/s10208-010-9060-6\">https://doi.org/10.1007/s10208-010-9060-6</a>","mla":"Cohen Steiner, David, et al. “Lipschitz Functions Have L_p-Stable Persistence.” <i>Foundations of Computational Mathematics</i>, vol. 10, no. 2, Springer, 2010, pp. 127–39, doi:<a href=\"https://doi.org/10.1007/s10208-010-9060-6\">10.1007/s10208-010-9060-6</a>.","ieee":"D. Cohen Steiner, H. Edelsbrunner, J. Harer, and Y. Mileyko, “Lipschitz functions have L_p-stable persistence,” <i>Foundations of Computational Mathematics</i>, vol. 10, no. 2. Springer, pp. 127–139, 2010."},"intvolume":"        10","issue":"2","quality_controlled":0,"status":"public","month":"01","publication":"Foundations of Computational Mathematics","extern":1,"_id":"3964","publist_id":"2163"},{"page":"485 - 494","isi":1,"type":"journal_article","ec_funded":1,"publication_status":"published","article_processing_charge":"No","year":"2010","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","date_published":"2010-03-15T00:00:00Z","abstract":[{"lang":"eng","text":"All species are restricted in their distribution. Currently, ecological models can only explain such limits if patches vary in quality, leading to asymmetrical dispersal, or if genetic variation is too low at the margins for adaptation. However, population genetic models suggest that the increase in genetic variance resulting from dispersal should allow adaptation to almost any ecological gradient. Clearly therefore, these models miss something that prevents evolution in natural populations. We developed an individual-based simulation to explore stochastic effects in these models. At high carrying capacities, our simulations largely agree with deterministic predictions. However, when carrying capacity is low, the population fails to establish for a wide range of parameter values where adaptation was expected from previous models. Stochastic or transient effects appear critical around the boundaries in parameter space between simulation behaviours. Dispersal, gradient steepness, and population density emerge as key factors determining adaptation on an ecological gradient. "}],"date_created":"2018-12-11T12:07:08Z","publisher":"Wiley-Blackwell","language":[{"iso":"eng"}],"intvolume":"        13","issue":"4","publication":"Ecology Letters","status":"public","month":"03","day":"15","acknowledgement":"We are very grateful to Nick Barton.","external_id":{"isi":["000275635400008"]},"author":[{"full_name":"Bridle, Jon","first_name":"Jon","last_name":"Bridle"},{"full_name":"Polechova, Jitka","id":"3BBFB084-F248-11E8-B48F-1D18A9856A87","last_name":"Polechova","orcid":"0000-0003-0951-3112","first_name":"Jitka"},{"last_name":"Kawata","first_name":"Masakado","full_name":"Kawata, Masakado"},{"last_name":"Butlin","first_name":"Roger","full_name":"Butlin, Roger"}],"title":"Why is adaptation prevented at ecological margins? New insights from individual-based simulations","date_updated":"2025-09-30T09:29:55Z","department":[{"_id":"NiBa"}],"scopus_import":"1","volume":13,"project":[{"call_identifier":"FP7","_id":"25681D80-B435-11E9-9278-68D0E5697425","name":"International IST Postdoc Fellowship Programme","grant_number":"291734"}],"doi":"10.1111/j.1461-0248.2010.01442.x","citation":{"chicago":"Bridle, Jon, Jitka Polechova, Masakado Kawata, and Roger Butlin. “Why Is Adaptation Prevented at Ecological Margins? New Insights from Individual-Based Simulations.” <i>Ecology Letters</i>. Wiley-Blackwell, 2010. <a href=\"https://doi.org/10.1111/j.1461-0248.2010.01442.x\">https://doi.org/10.1111/j.1461-0248.2010.01442.x</a>.","short":"J. Bridle, J. Polechova, M. Kawata, R. Butlin, Ecology Letters 13 (2010) 485–494.","ieee":"J. Bridle, J. Polechova, M. Kawata, and R. Butlin, “Why is adaptation prevented at ecological margins? New insights from individual-based simulations,” <i>Ecology Letters</i>, vol. 13, no. 4. Wiley-Blackwell, pp. 485–494, 2010.","mla":"Bridle, Jon, et al. “Why Is Adaptation Prevented at Ecological Margins? New Insights from Individual-Based Simulations.” <i>Ecology Letters</i>, vol. 13, no. 4, Wiley-Blackwell, 2010, pp. 485–94, doi:<a href=\"https://doi.org/10.1111/j.1461-0248.2010.01442.x\">10.1111/j.1461-0248.2010.01442.x</a>.","ista":"Bridle J, Polechova J, Kawata M, Butlin R. 2010. Why is adaptation prevented at ecological margins? New insights from individual-based simulations. Ecology Letters. 13(4), 485–494.","ama":"Bridle J, Polechova J, Kawata M, Butlin R. Why is adaptation prevented at ecological margins? New insights from individual-based simulations. <i>Ecology Letters</i>. 2010;13(4):485-494. doi:<a href=\"https://doi.org/10.1111/j.1461-0248.2010.01442.x\">10.1111/j.1461-0248.2010.01442.x</a>","apa":"Bridle, J., Polechova, J., Kawata, M., &#38; Butlin, R. (2010). Why is adaptation prevented at ecological margins? New insights from individual-based simulations. <i>Ecology Letters</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1111/j.1461-0248.2010.01442.x\">https://doi.org/10.1111/j.1461-0248.2010.01442.x</a>"},"_id":"4134","publist_id":"1987","oa_version":"None","quality_controlled":"1"},{"quality_controlled":"1","oa_version":"Submitted Version","main_file_link":[{"url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924654/","open_access":"1"}],"_id":"4157","publist_id":"1962","doi":"10.1038/emboj.2010.182","citation":{"ieee":"E. Papusheva and C.-P. J. Heisenberg, “Spatial organization of adhesion: force-dependent regulation and function in tissue morphogenesis,” <i>EMBO Journal</i>, vol. 29, no. 16. Wiley-Blackwell, pp. 2753–2768, 2010.","mla":"Papusheva, Ekaterina, and Carl-Philipp J. Heisenberg. “Spatial Organization of Adhesion: Force-Dependent Regulation and Function in Tissue Morphogenesis.” <i>EMBO Journal</i>, vol. 29, no. 16, Wiley-Blackwell, 2010, pp. 2753–68, doi:<a href=\"https://doi.org/10.1038/emboj.2010.182\">10.1038/emboj.2010.182</a>.","ista":"Papusheva E, Heisenberg C-PJ. 2010. Spatial organization of adhesion: force-dependent regulation and function in tissue morphogenesis. EMBO Journal. 29(16), 2753–2768.","apa":"Papusheva, E., &#38; Heisenberg, C.-P. J. (2010). Spatial organization of adhesion: force-dependent regulation and function in tissue morphogenesis. <i>EMBO Journal</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1038/emboj.2010.182\">https://doi.org/10.1038/emboj.2010.182</a>","ama":"Papusheva E, Heisenberg C-PJ. Spatial organization of adhesion: force-dependent regulation and function in tissue morphogenesis. <i>EMBO Journal</i>. 2010;29(16):2753-2768. doi:<a href=\"https://doi.org/10.1038/emboj.2010.182\">10.1038/emboj.2010.182</a>","chicago":"Papusheva, Ekaterina, and Carl-Philipp J Heisenberg. “Spatial Organization of Adhesion: Force-Dependent Regulation and Function in Tissue Morphogenesis.” <i>EMBO Journal</i>. Wiley-Blackwell, 2010. <a href=\"https://doi.org/10.1038/emboj.2010.182\">https://doi.org/10.1038/emboj.2010.182</a>.","short":"E. Papusheva, C.-P.J. Heisenberg, EMBO Journal 29 (2010) 2753–2768."},"volume":29,"department":[{"_id":"Bio"},{"_id":"CaHe"}],"scopus_import":"1","title":"Spatial organization of adhesion: force-dependent regulation and function in tissue morphogenesis","date_updated":"2025-09-30T09:29:30Z","author":[{"first_name":"Ekaterina","last_name":"Papusheva","id":"41DB591E-F248-11E8-B48F-1D18A9856A87","full_name":"Papusheva, Ekaterina"},{"orcid":"0000-0002-0912-4566","last_name":"Heisenberg","first_name":"Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87","full_name":"Heisenberg, Carl-Philipp J"}],"external_id":{"pmid":["20717145"],"isi":["000281006400009"]},"day":"18","publication":"EMBO Journal","status":"public","month":"08","acknowledged_ssus":[{"_id":"Bio"}],"issue":"16","intvolume":"        29","language":[{"iso":"eng"}],"publisher":"Wiley-Blackwell","date_created":"2018-12-11T12:07:17Z","pmid":1,"abstract":[{"text":"Integrin- and cadherin-mediated adhesion is central for cell and tissue morphogenesis, allowing cells and tissues to change shape without loosing integrity. Studies predominantly in cell culture showed that mechanosensation through adhesion structures is achieved by force-mediated modulation of their molecular composition. The specific molecular composition of adhesion sites in turn determines their signalling activity and dynamic reorganization. Here, we will review how adhesion sites respond to mecanical stimuli, and how spatially and temporally regulated signalling from different adhesion sites controls cell migration and tissue morphogenesis.","lang":"eng"}],"date_published":"2010-08-18T00:00:00Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","publication_status":"published","year":"2010","article_processing_charge":"No","oa":1,"type":"journal_article","isi":1,"page":"2753 - 2768"},{"title":"Planar cell polarity signalling regulates cell adhesion properties in progenitors of the zebrafish laterality organ","date_updated":"2021-01-12T07:54:58Z","date_published":"2010-10-15T00:00:00Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"last_name":"Oteíza","first_name":"Pablo","full_name":"Oteíza, Pablo"},{"full_name":"Koeppen, Mathias","last_name":"Koeppen","first_name":"Mathias"},{"full_name":"Krieg, Michael","first_name":"Michael","last_name":"Krieg"},{"first_name":"Eduardo","last_name":"Pulgar","full_name":"Pulgar, Eduardo"},{"full_name":"Farias, Cecilia","last_name":"Farias","first_name":"Cecilia"},{"full_name":"Melo, Cristina","first_name":"Cristina","last_name":"Melo"},{"full_name":"Preibisch, Steffen","first_name":"Steffen","last_name":"Preibisch"},{"last_name":"Mueller","first_name":"Daniel","full_name":"Mueller, Daniel"},{"last_name":"Tada","first_name":"Masazumi","full_name":"Tada, Masazumi"},{"full_name":"Hartel, Steffen","last_name":"Hartel","first_name":"Steffen"},{"first_name":"Carl-Philipp J","orcid":"0000-0002-0912-4566","last_name":"Heisenberg","id":"39427864-F248-11E8-B48F-1D18A9856A87","full_name":"Heisenberg, Carl-Philipp J"},{"full_name":"Concha, Miguel","first_name":"Miguel","last_name":"Concha"}],"publication_status":"published","year":"2010","article_processing_charge":"No","type":"journal_article","page":"3459 - 3468","day":"15","status":"public","publication":"Development","oa_version":"None","month":"10","_id":"4163","extern":"1","publist_id":"1958","issue":"20","doi":"10.1242/dev.049981","citation":{"mla":"Oteíza, Pablo, et al. “Planar Cell Polarity Signalling Regulates Cell Adhesion Properties in Progenitors of the Zebrafish Laterality Organ.” <i>Development</i>, vol. 137, no. 20, Company of Biologists, 2010, pp. 3459–68, doi:<a href=\"https://doi.org/10.1242/dev.049981\">10.1242/dev.049981</a>.","ieee":"P. Oteíza <i>et al.</i>, “Planar cell polarity signalling regulates cell adhesion properties in progenitors of the zebrafish laterality organ,” <i>Development</i>, vol. 137, no. 20. Company of Biologists, pp. 3459–3468, 2010.","apa":"Oteíza, P., Koeppen, M., Krieg, M., Pulgar, E., Farias, C., Melo, C., … Concha, M. (2010). Planar cell polarity signalling regulates cell adhesion properties in progenitors of the zebrafish laterality organ. <i>Development</i>. Company of Biologists. <a href=\"https://doi.org/10.1242/dev.049981\">https://doi.org/10.1242/dev.049981</a>","ista":"Oteíza P, Koeppen M, Krieg M, Pulgar E, Farias C, Melo C, Preibisch S, Mueller D, Tada M, Hartel S, Heisenberg C-PJ, Concha M. 2010. Planar cell polarity signalling regulates cell adhesion properties in progenitors of the zebrafish laterality organ. Development. 137(20), 3459–3468.","ama":"Oteíza P, Koeppen M, Krieg M, et al. Planar cell polarity signalling regulates cell adhesion properties in progenitors of the zebrafish laterality organ. <i>Development</i>. 2010;137(20):3459-3468. doi:<a href=\"https://doi.org/10.1242/dev.049981\">10.1242/dev.049981</a>","chicago":"Oteíza, Pablo, Mathias Koeppen, Michael Krieg, Eduardo Pulgar, Cecilia Farias, Cristina Melo, Steffen Preibisch, et al. “Planar Cell Polarity Signalling Regulates Cell Adhesion Properties in Progenitors of the Zebrafish Laterality Organ.” <i>Development</i>. Company of Biologists, 2010. <a href=\"https://doi.org/10.1242/dev.049981\">https://doi.org/10.1242/dev.049981</a>.","short":"P. Oteíza, M. Koeppen, M. Krieg, E. Pulgar, C. Farias, C. Melo, S. Preibisch, D. Mueller, M. Tada, S. Hartel, C.-P.J. Heisenberg, M. Concha, Development 137 (2010) 3459–3468."},"intvolume":"       137","language":[{"iso":"eng"}],"publisher":"Company of Biologists","volume":137,"date_created":"2018-12-11T12:07:20Z","abstract":[{"lang":"eng","text":"Organ formation requires the precise assembly of progenitor cells into a functional multicellular structure. Mechanical forces probably participate in this process but how they influence organ morphogenesis is still unclear. Here, we show that Wnt11- and Prickle1a-mediated planar cell polarity (PCP) signalling coordinates the formation of the zebrafish ciliated laterality organ (Kupffer's vesicle) by regulating adhesion properties between organ progenitor cells (the dorsal forerunner cells, DFCs). Combined inhibition of Wnt11 and Prickle1a reduces DFC cell-cell adhesion and impairs their compaction and arrangement during vesicle lumen formation. This leads to the formation of a mis-shapen vesicle with small fragmented lumina and shortened cilia, resulting in severely impaired organ function and, as a consequence, randomised laterality of both molecular and visceral asymmetries. Our results reveal a novel role for PCP-dependent cell adhesion in coordinating the supracellular organisation of progenitor cells during vertebrate laterality organ formation."}]},{"publisher":"Nature Publishing Group","volume":12,"abstract":[{"text":"Cell migration is central to embryonic development, homeostasis and disease(1), processes in which cells move as part of a group or individually. Whereas the mechanisms controlling single-cell migration in vitro are relatively well understood(2-4), less is known about the mechanisms promoting the motility of individual cells in vivo. In particular, it is not clear how cells that form blebs in their migration use those protrusions to bring about movement in the context of the three-dimensional cellular environment(5,6). Here we show that the motility of chemokine-guided germ cells within the zebrafish embryo requires the function of the small Rho GTPases Rac1 and RhoA, as well as E-cadherin-mediated cell-cell adhesion. Using fluorescence resonance energy transfer we demonstrate that Rac1 and RhoA are activated in the cell front. At this location, Rac1 is responsible for the formation of actin-rich structures, and RhoA promotes retrograde actin flow. We propose that these actin-rich structures undergoing retrograde flow are essential for the generation of E-cadherin-mediated traction forces between the germ cells and the surrounding tissue and are therefore crucial for cell motility in vivo.","lang":"eng"}],"date_created":"2018-12-11T12:07:28Z","doi":"10.1038/ncb2003","intvolume":"        12","citation":{"mla":"Kardash, Elena, et al. “A Role for Rho GTPases and Cell-Cell Adhesion in Single-Cell Motility in Vivo.” <i>Nature Cell Biology</i>, vol. 12, no. 1, Nature Publishing Group, 2010, pp. 47–53, doi:<a href=\"https://doi.org/10.1038/ncb2003\">10.1038/ncb2003</a>.","ieee":"E. Kardash <i>et al.</i>, “A role for Rho GTPases and cell-cell adhesion in single-cell motility in vivo,” <i>Nature Cell Biology</i>, vol. 12, no. 1. Nature Publishing Group, pp. 47–53, 2010.","apa":"Kardash, E., Reichman Fried, M., Maître, J., Boldajipour, B., Papusheva, E., Messerschmidt, E., … Raz, E. (2010). A role for Rho GTPases and cell-cell adhesion in single-cell motility in vivo. <i>Nature Cell Biology</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/ncb2003\">https://doi.org/10.1038/ncb2003</a>","ista":"Kardash E, Reichman Fried M, Maître J, Boldajipour B, Papusheva E, Messerschmidt E, Heisenberg C, Raz E. 2010. A role for Rho GTPases and cell-cell adhesion in single-cell motility in vivo. Nature Cell Biology. 12(1), 47–53.","ama":"Kardash E, Reichman Fried M, Maître J, et al. A role for Rho GTPases and cell-cell adhesion in single-cell motility in vivo. <i>Nature Cell Biology</i>. 2010;12(1):47-53. doi:<a href=\"https://doi.org/10.1038/ncb2003\">10.1038/ncb2003</a>","chicago":"Kardash, Elena, Michal Reichman Fried, Jean Maître, Bijan Boldajipour, Ekaterina Papusheva, Esther Messerschmidt, Carl Heisenberg, and Erez Raz. “A Role for Rho GTPases and Cell-Cell Adhesion in Single-Cell Motility in Vivo.” <i>Nature Cell Biology</i>. Nature Publishing Group, 2010. <a href=\"https://doi.org/10.1038/ncb2003\">https://doi.org/10.1038/ncb2003</a>.","short":"E. Kardash, M. Reichman Fried, J. Maître, B. Boldajipour, E. Papusheva, E. Messerschmidt, C. Heisenberg, E. Raz, Nature Cell Biology 12 (2010) 47–53."},"issue":"1","month":"01","publication":"Nature Cell Biology","quality_controlled":0,"status":"public","_id":"4187","extern":1,"publist_id":"1932","page":"47 - 53","day":"01","type":"journal_article","author":[{"full_name":"Kardash, Elena","first_name":"Elena","last_name":"Kardash"},{"full_name":"Reichman-Fried, Michal","first_name":"Michal","last_name":"Reichman Fried"},{"last_name":"Maître","first_name":"Jean","full_name":"Maître, Jean-Léon"},{"full_name":"Boldajipour, Bijan","first_name":"Bijan","last_name":"Boldajipour"},{"first_name":"Ekaterina","last_name":"Papusheva","id":"41DB591E-F248-11E8-B48F-1D18A9856A87","full_name":"Ekaterina Papusheva"},{"full_name":"Messerschmidt, Esther-Maria","last_name":"Messerschmidt","first_name":"Esther"},{"full_name":"Heisenberg, Carl-Philipp","first_name":"Carl","last_name":"Heisenberg"},{"full_name":"Raz, Erez","first_name":"Erez","last_name":"Raz"}],"publication_status":"published","year":"2010","title":"A role for Rho GTPases and cell-cell adhesion in single-cell motility in vivo","date_updated":"2021-01-12T07:55:09Z","date_published":"2010-01-01T00:00:00Z"},{"day":"26","page":"161 - 169","type":"journal_article","publication_status":"published","article_processing_charge":"No","year":"2010","author":[{"first_name":"Yohanna","last_name":"Arboleda Estudillo","full_name":"Arboleda Estudillo, Yohanna"},{"full_name":"Krieg, Michael","first_name":"Michael","last_name":"Krieg"},{"last_name":"Stuehmer","first_name":"Jan","full_name":"Stuehmer, Jan"},{"last_name":"Licata","first_name":"Nicholas","full_name":"Licata, Nicholas"},{"full_name":"Mueller, Daniel","last_name":"Mueller","first_name":"Daniel"},{"last_name":"Heisenberg","orcid":"0000-0002-0912-4566","first_name":"Carl-Philipp J","full_name":"Heisenberg, Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Movement directionality in collective migration of germ layer progenitors","date_updated":"2021-01-12T07:55:25Z","date_published":"2010-01-26T00:00:00Z","date_created":"2018-12-11T12:07:40Z","abstract":[{"text":"Collective cell migration, the simultaneous movement of multiple cells that are connected by cell-cell adhesion, is ubiquitous in development, tissue repair, and tumor metastasis [1, 2]. It has been hypothesized that the directionality of cell movement during collective migration emerges as a collective property [3, 4]. Here we determine how movement directionality is established in collective mesendoderm migration during zebrafish gastrulation. By interfering with two key features of collective migration, (1) having neighboring cells and (2) adhering to them, we show that individual mesendoderm cells are capable of normal directed migration when moving as single cells but require cell-cell adhesion to participate in coordinated and directed migration when moving as part of a group. We conclude that movement directionality is not a de novo collective property of mesendoderm cells but rather a property of single mesendoderm cells that requires cell-cell adhesion during collective migration.","lang":"eng"}],"publisher":"Cell Press","volume":20,"language":[{"iso":"eng"}],"doi":"10.1016/j.cub.2009.11.036","intvolume":"        20","citation":{"ieee":"Y. Arboleda Estudillo, M. Krieg, J. Stuehmer, N. Licata, D. Mueller, and C.-P. J. Heisenberg, “Movement directionality in collective migration of germ layer progenitors,” <i>Current Biology</i>, vol. 20, no. 2. Cell Press, pp. 161–169, 2010.","mla":"Arboleda Estudillo, Yohanna, et al. “Movement Directionality in Collective Migration of Germ Layer Progenitors.” <i>Current Biology</i>, vol. 20, no. 2, Cell Press, 2010, pp. 161–69, doi:<a href=\"https://doi.org/10.1016/j.cub.2009.11.036\">10.1016/j.cub.2009.11.036</a>.","ista":"Arboleda Estudillo Y, Krieg M, Stuehmer J, Licata N, Mueller D, Heisenberg C-PJ. 2010. Movement directionality in collective migration of germ layer progenitors. Current Biology. 20(2), 161–169.","apa":"Arboleda Estudillo, Y., Krieg, M., Stuehmer, J., Licata, N., Mueller, D., &#38; Heisenberg, C.-P. J. (2010). Movement directionality in collective migration of germ layer progenitors. <i>Current Biology</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.cub.2009.11.036\">https://doi.org/10.1016/j.cub.2009.11.036</a>","ama":"Arboleda Estudillo Y, Krieg M, Stuehmer J, Licata N, Mueller D, Heisenberg C-PJ. Movement directionality in collective migration of germ layer progenitors. <i>Current Biology</i>. 2010;20(2):161-169. doi:<a href=\"https://doi.org/10.1016/j.cub.2009.11.036\">10.1016/j.cub.2009.11.036</a>","chicago":"Arboleda Estudillo, Yohanna, Michael Krieg, Jan Stuehmer, Nicholas Licata, Daniel Mueller, and Carl-Philipp J Heisenberg. “Movement Directionality in Collective Migration of Germ Layer Progenitors.” <i>Current Biology</i>. Cell Press, 2010. <a href=\"https://doi.org/10.1016/j.cub.2009.11.036\">https://doi.org/10.1016/j.cub.2009.11.036</a>.","short":"Y. Arboleda Estudillo, M. Krieg, J. Stuehmer, N. Licata, D. Mueller, C.-P.J. Heisenberg, Current Biology 20 (2010) 161–169."},"issue":"2","extern":"1","_id":"4221","publist_id":"1897","publication":"Current Biology","status":"public","oa_version":"None","month":"01"},{"volume":15,"scopus_import":"1","department":[{"_id":"NiBa"}],"doi":"10.1214/EJP.v15-741","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"citation":{"ista":"Barton NH, Etheridge A, Véber A. 2010. A new model for evolution in a spatial continuum. Electronic Journal of Probability. 15(7), 162–216.","ama":"Barton NH, Etheridge A, Véber A. A new model for evolution in a spatial continuum. <i>Electronic Journal of Probability</i>. 2010;15(7):162-216. doi:<a href=\"https://doi.org/10.1214/EJP.v15-741\">10.1214/EJP.v15-741</a>","apa":"Barton, N. H., Etheridge, A., &#38; Véber, A. (2010). A new model for evolution in a spatial continuum. <i>Electronic Journal of Probability</i>. Institute of Mathematical Statistics. <a href=\"https://doi.org/10.1214/EJP.v15-741\">https://doi.org/10.1214/EJP.v15-741</a>","ieee":"N. H. Barton, A. Etheridge, and A. Véber, “A new model for evolution in a spatial continuum,” <i>Electronic Journal of Probability</i>, vol. 15, no. 7. Institute of Mathematical Statistics, pp. 162–216, 2010.","mla":"Barton, Nicholas H., et al. “A New Model for Evolution in a Spatial Continuum.” <i>Electronic Journal of Probability</i>, vol. 15, no. 7, Institute of Mathematical Statistics, 2010, pp. 162–216, doi:<a href=\"https://doi.org/10.1214/EJP.v15-741\">10.1214/EJP.v15-741</a>.","short":"N.H. Barton, A. Etheridge, A. Véber, Electronic Journal of Probability 15 (2010) 162–216.","chicago":"Barton, Nicholas H, Alison Etheridge, and Amandine Véber. “A New Model for Evolution in a Spatial Continuum.” <i>Electronic Journal of Probability</i>. Institute of Mathematical Statistics, 2010. <a href=\"https://doi.org/10.1214/EJP.v15-741\">https://doi.org/10.1214/EJP.v15-741</a>."},"pubrep_id":"369","oa_version":"Published Version","quality_controlled":"1","publist_id":"1863","_id":"4243","file_date_updated":"2020-07-14T12:46:26Z","day":"03","external_id":{"isi":["000274822400001"]},"license":"https://creativecommons.org/licenses/by/4.0/","author":[{"last_name":"Barton","orcid":"0000-0002-8548-5240","first_name":"Nicholas H","full_name":"Barton, Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Etheridge, Alison","last_name":"Etheridge","first_name":"Alison"},{"last_name":"Véber","first_name":"Amandine","full_name":"Véber, Amandine"}],"date_updated":"2025-09-30T09:28:54Z","title":"A new model for evolution in a spatial continuum","publisher":"Institute of Mathematical Statistics","has_accepted_license":"1","date_created":"2018-12-11T12:07:48Z","abstract":[{"lang":"eng","text":"We investigate a new model for populations evolving in a spatial continuum. This model can be thought of as a spatial version of the Lambda-Fleming-Viot process. It explicitly incorporates both small scale reproduction events and large scale extinction-recolonisation events. The lineages ancestral to a sample from a population evolving according to this model can be described in terms of a spatial version of the Lambda-coalescent. Using a technique of Evans (1997), we prove existence and uniqueness in law for the model. We then investigate the asymptotic behaviour of the genealogy of a finite number of individuals sampled uniformly at random (or more generally `far enough apart') from a two-dimensional torus of sidelength L as L tends to infinity. Under appropriate conditions (and on a suitable timescale) we can obtain as limiting genealogical processes a Kingman coalescent, a more general Lambda-coalescent or a system of coalescing Brownian motions (with a non-local coalescence mechanism)."}],"intvolume":"        15","language":[{"iso":"eng"}],"issue":"7","status":"public","month":"02","ddc":["576"],"publication":"Electronic Journal of Probability","page":"162 - 216","oa":1,"isi":1,"type":"journal_article","file":[{"file_id":"5140","date_updated":"2020-07-14T12:46:26Z","checksum":"bab577546dd4e8f882e9a9dd645cd01e","creator":"system","file_name":"IST-2015-369-v1+1_741-2535-1-PB.pdf","date_created":"2018-12-12T10:15:21Z","relation":"main_file","access_level":"open_access","content_type":"application/pdf","file_size":450171}],"article_processing_charge":"No","year":"2010","publication_status":"published","date_published":"2010-02-03T00:00:00Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345"},{"file":[{"access_level":"open_access","content_type":"application/pdf","file_size":567580,"creator":"system","checksum":"d42cedd48fffa85d75046f396a309fc3","file_name":"IST-2012-12-v1+1_9783110232103.5.pdf","date_created":"2018-12-12T10:15:06Z","relation":"main_file","date_updated":"2020-07-14T12:46:27Z","file_id":"5123"}],"series_title":"Bibliotheks- und Informationspraxis 41","article_processing_charge":"No","year":"2010","publication_status":"published","date_published":"2010-09-23T00:00:00Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","page":"5 - 20","editor":[{"last_name":"Bergmann","first_name":"Julia","full_name":"Bergmann, Julia"},{"first_name":"Patrick","last_name":"Danowski","orcid":"0000-0002-6026-4409","full_name":"Danowski, Patrick","id":"2EBD1598-F248-11E8-B48F-1D18A9856A87"}],"oa":1,"type":"book_chapter","month":"09","ddc":["020"],"status":"public","publication":"Handbuch Bibliothek 2.0","publisher":"De Gruyter","abstract":[{"text":"Mit diesem Buch möchten wir einen Überblick der aktuellen Diskussion zum Thema Bibliothek 2.0 geben und den Stand der tatsächlichen Umsetzung der Web 2.0-Ansätze in deutschsprachigen Bibliotheken beleuchten. An dieser Stelle ist die Frage erlaubt, warum es zu einer Zeit, in der es bereits die ersten \"Web 3.0\"- Konferenzen gibt, eines Handbuches der Bibliothek 2.0 noch bedarf. Und warum es überhaupt ein deutschsprachiges Handbuch zur Bibliothek 2.0 braucht, wo es doch bereits verschiedenste Publikationen zu diesem Thema aus anderen Ländern, insbesondere des angloamerikanischen Raums gibt. Ist dazu nicht bereits alles gesagt?","lang":"ger"}],"has_accepted_license":"1","date_created":"2018-12-11T12:08:21Z","language":[{"iso":"eng"}],"author":[{"first_name":"Julia","last_name":"Bergmann","full_name":"Bergmann, Julia"},{"first_name":"Patrick","last_name":"Danowski","orcid":"0000-0002-6026-4409","full_name":"Danowski, Patrick","id":"2EBD1598-F248-11E8-B48F-1D18A9856A87"}],"date_updated":"2025-07-02T11:25:10Z","title":"Ist Bibliothek 2.0 überhaupt noch relevant? – Eine Einleitung in das Handbuch","file_date_updated":"2020-07-14T12:46:27Z","day":"23","pubrep_id":"12","quality_controlled":"1","oa_version":"Published Version","publist_id":"1235","_id":"4339","extern":"1","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"doi":"10.1515/9783110232103","citation":{"ista":"Bergmann J, Danowski P. 2010.Ist Bibliothek 2.0 überhaupt noch relevant? – Eine Einleitung in das Handbuch. In: Handbuch Bibliothek 2.0. , 5–20.","apa":"Bergmann, J., &#38; Danowski, P. (2010). Ist Bibliothek 2.0 überhaupt noch relevant? – Eine Einleitung in das Handbuch. In J. Bergmann &#38; P. Danowski (Eds.), <i>Handbuch Bibliothek 2.0</i> (pp. 5–20). De Gruyter. <a href=\"https://doi.org/10.1515/9783110232103\">https://doi.org/10.1515/9783110232103</a>","ama":"Bergmann J, Danowski P. Ist Bibliothek 2.0 überhaupt noch relevant? – Eine Einleitung in das Handbuch. In: Bergmann J, Danowski P, eds. <i>Handbuch Bibliothek 2.0</i>. Bibliotheks- und Informationspraxis 41. De Gruyter; 2010:5-20. doi:<a href=\"https://doi.org/10.1515/9783110232103\">10.1515/9783110232103</a>","mla":"Bergmann, Julia, and Patrick Danowski. “Ist Bibliothek 2.0 Überhaupt Noch Relevant? – Eine Einleitung in Das Handbuch.” <i>Handbuch Bibliothek 2.0</i>, edited by Julia Bergmann and Patrick Danowski, De Gruyter, 2010, pp. 5–20, doi:<a href=\"https://doi.org/10.1515/9783110232103\">10.1515/9783110232103</a>.","ieee":"J. Bergmann and P. Danowski, “Ist Bibliothek 2.0 überhaupt noch relevant? – Eine Einleitung in das Handbuch,” in <i>Handbuch Bibliothek 2.0</i>, J. Bergmann and P. Danowski, Eds. De Gruyter, 2010, pp. 5–20.","short":"J. Bergmann, P. Danowski, in:, J. Bergmann, P. Danowski (Eds.), Handbuch Bibliothek 2.0, De Gruyter, 2010, pp. 5–20.","chicago":"Bergmann, Julia, and Patrick Danowski. “Ist Bibliothek 2.0 Überhaupt Noch Relevant? – Eine Einleitung in Das Handbuch.” In <i>Handbuch Bibliothek 2.0</i>, edited by Julia Bergmann and Patrick Danowski, 5–20. Bibliotheks- Und Informationspraxis 41. De Gruyter, 2010. <a href=\"https://doi.org/10.1515/9783110232103\">https://doi.org/10.1515/9783110232103</a>."}},{"month":"06","publication":"European Library Automation Group (ELAG) 2010","oa_version":"None","ddc":["020"],"status":"public","main_file_link":[{"url":"http://www.slideshare.net/PatrickD/open-bibliographic-data-elag2010","open_access":"1"}],"_id":"4340","extern":"1","publist_id":"1234","citation":{"mla":"Danowski, Patrick. “Open Bibliographic Data.” <i>European Library Automation Group (ELAG) 2010</i>, Elsevier, 2010.","ieee":"P. Danowski, <i>Open bibliographic data</i>. Elsevier, 2010.","ista":"Danowski P. 2010. Open bibliographic data, Elsevier,p.","ama":"Danowski P. <i>Open Bibliographic Data</i>. Elsevier; 2010.","apa":"Danowski, P. (2010). <i>Open bibliographic data</i>. <i>European Library Automation Group (ELAG) 2010</i>. Elsevier.","chicago":"Danowski, Patrick. <i>Open Bibliographic Data</i>. <i>European Library Automation Group (ELAG) 2010</i>. Elsevier, 2010.","short":"P. Danowski, Open Bibliographic Data, Elsevier, 2010."},"tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"language":[{"iso":"eng"}],"publisher":"Elsevier","abstract":[{"text":"More and more libraries starting semantic web projects. The question about the license of the data\r\nis not discussed or the discussion is deferred to the end of project. in this paper is discussed why\r\nthe question of the license is so important in context of the semantic web that is should be one of the\r\nfirst aspects in a semantic web project. Also it will be shown why a public domain weaver is the\r\nonly solution that fulfill the the special requirements of the semantic web and that guaranties the\r\nreuseablitly of semantic library data for a sustainability of the projects. ","lang":"eng"}],"date_created":"2018-12-11T12:08:21Z","has_accepted_license":"1","title":"Open bibliographic data","date_updated":"2020-07-14T23:07:19Z","date_published":"2010-06-10T00:00:00Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"full_name":"Danowski, Patrick","id":"2EBD1598-F248-11E8-B48F-1D18A9856A87","last_name":"Danowski","orcid":"0000-0002-6026-4409","first_name":"Patrick"}],"file":[{"date_updated":"2020-07-14T12:46:27Z","file_id":"5118","file_size":94982,"access_level":"open_access","content_type":"application/pdf","date_created":"2018-12-12T10:15:01Z","relation":"main_file","creator":"system","checksum":"7061756135333d73b26a84526fa654f5","file_name":"IST-2012-51-v1+1_149-danowski-en.pdf"}],"publication_status":"published","year":"2010","oa":1,"conference":{"name":"ELAG: European Library Automation Group"},"type":"other_academic_publication","day":"10","file_date_updated":"2020-07-14T12:46:27Z"},{"quality_controlled":0,"month":"08","status":"public","main_file_link":[{"url":"http://www.ifla.org/files/hq/papers/ifla76/149-danowski-en.pdf","open_access":"0"}],"_id":"4341","extern":1,"publist_id":"1233","pubrep_id":"51","citation":{"short":"P. Danowski, in:, IFLA, 2010.","chicago":"Danowski, Patrick. “Step One: Blow up the Silo! - Open Bibliographic Data, the First Step towards Linked Open Data.” IFLA, 2010.","ista":"Danowski P. 2010. Step one: blow up the silo! - Open bibliographic data, the first step towards Linked Open Data. WLIC: World Library and Information Congress, IFLA , .","apa":"Danowski, P. (2010). Step one: blow up the silo! - Open bibliographic data, the first step towards Linked Open Data. Presented at the WLIC: World Library and Information Congress, IFLA.","ama":"Danowski P. Step one: blow up the silo! - Open bibliographic data, the first step towards Linked Open Data. In: IFLA; 2010.","ieee":"P. Danowski, “Step one: blow up the silo! - Open bibliographic data, the first step towards Linked Open Data,” presented at the WLIC: World Library and Information Congress, 2010.","mla":"Danowski, Patrick. <i>Step One: Blow up the Silo! - Open Bibliographic Data, the First Step towards Linked Open Data</i>. IFLA, 2010."},"publisher":"IFLA","date_created":"2018-12-11T12:08:21Z","abstract":[{"lang":"eng","text":"More and more libraries starting semantic web projects. The question about the license of the data is not discussed or the discussion is deferred to the end of project. in this paper is discussed why the question of the license is so important in context of the semantic web that is should be one of the first aspects in a semantic web project. Also it will be shown why a public domain weaver is the only solution that fulfill the the special requirements of the semantic web and that guaranties the reuseablitly of semantic library data for a sustainability of the projects."}],"alternative_title":["IFLA "],"title":"Step one: blow up the silo! - Open bibliographic data, the first step towards Linked Open Data","date_updated":"2021-01-12T07:56:16Z","date_published":"2010-08-01T00:00:00Z","author":[{"orcid":"0000-0002-6026-4409","last_name":"Danowski","first_name":"Patrick","id":"2EBD1598-F248-11E8-B48F-1D18A9856A87","full_name":"Patrick Danowski"}],"publication_status":"published","year":"2010","conference":{"name":"WLIC: World Library and Information Congress"},"type":"conference","day":"01"},{"acknowledgement":"AK is funded by a Marie Curie fellowship. JB is funded by the MRC (UK). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript","day":"01","type":"journal_article","year":"2010","publication_status":"published","author":[{"full_name":"Anna Kicheva","id":"3959A2A0-F248-11E8-B48F-1D18A9856A87","last_name":"Kicheva","orcid":"0000-0003-4509-4998","first_name":"Anna"},{"full_name":"Briscoe, James","last_name":"Briscoe","first_name":"James"}],"date_published":"2010-07-01T00:00:00Z","date_updated":"2021-01-12T06:52:45Z","title":"Limbs made to measure","date_created":"2018-12-11T11:53:39Z","volume":8,"publisher":"Public Library of Science","intvolume":"         8","citation":{"mla":"Kicheva, Anna, and James Briscoe. “Limbs Made to Measure.” <i>PLoS Biology</i>, vol. 8, no. 7, Public Library of Science, 2010, doi:<a href=\"https://doi.org/10.1371/journal.pbio.1000421\">10.1371/journal.pbio.1000421</a>.","ieee":"A. Kicheva and J. Briscoe, “Limbs made to measure,” <i>PLoS Biology</i>, vol. 8, no. 7. Public Library of Science, 2010.","ama":"Kicheva A, Briscoe J. Limbs made to measure. <i>PLoS Biology</i>. 2010;8(7). doi:<a href=\"https://doi.org/10.1371/journal.pbio.1000421\">10.1371/journal.pbio.1000421</a>","ista":"Kicheva A, Briscoe J. 2010. Limbs made to measure. PLoS Biology. 8(7).","apa":"Kicheva, A., &#38; Briscoe, J. (2010). Limbs made to measure. <i>PLoS Biology</i>. Public Library of Science. <a href=\"https://doi.org/10.1371/journal.pbio.1000421\">https://doi.org/10.1371/journal.pbio.1000421</a>","chicago":"Kicheva, Anna, and James Briscoe. “Limbs Made to Measure.” <i>PLoS Biology</i>. Public Library of Science, 2010. <a href=\"https://doi.org/10.1371/journal.pbio.1000421\">https://doi.org/10.1371/journal.pbio.1000421</a>.","short":"A. Kicheva, J. Briscoe, PLoS Biology 8 (2010)."},"doi":"10.1371/journal.pbio.1000421","issue":"7","publist_id":"5407","extern":1,"_id":"1721","quality_controlled":0,"status":"public","publication":"PLoS Biology","month":"07"},{"title":"Dynamic assignment and maintenance of positional identity in the ventral neural tube by the morphogen sonic hedgehog","date_updated":"2021-01-12T06:52:46Z","date_published":"2010-06-01T00:00:00Z","author":[{"full_name":"Dessaud, Éric","first_name":"Éric","last_name":"Dessaud"},{"first_name":"Vanessa","last_name":"Ribes","full_name":"Ribes, Vanessa"},{"full_name":"Balaskas, Nikolaos","first_name":"Nikolaos","last_name":"Balaskas"},{"full_name":"Yang, Linlin","last_name":"Yang","first_name":"Linlin"},{"full_name":"Pierani, Alessandra","first_name":"Alessandra","last_name":"Pierani"},{"full_name":"Anna Kicheva","id":"3959A2A0-F248-11E8-B48F-1D18A9856A87","last_name":"Kicheva","orcid":"0000-0003-4509-4998","first_name":"Anna"},{"full_name":"Novitch, Bennett","last_name":"Novitch","first_name":"Bennett"},{"first_name":"James","last_name":"Briscoe","full_name":"Briscoe, James"},{"last_name":"Sasai","first_name":"Noriaki","full_name":"Sasai, Noriaki"}],"publication_status":"published","year":"2010","type":"journal_article","day":"01","acknowledgement":"NS was supported by a Marie Curie Fellowship (PIIF-GA-2008-219939) and the Mochida Memorial Foundation for Medical and Pharmaceutical Research. Support for VR was provided by an EMBO LTF, for AK by a FEBS LTF. ED was supported by the Wellcome Trust (#080630). Work in the lab of JB is supported by the Medical Research Council (UK). AP is a CNRS (Centre National de la Recherche Scientifique) Investigator. This work was supported by grants from the Ministère de la Recherche (ACI Grant #0220575) and the Association pour la Recherche sur le Cancer (Grant #4679) to AP. BGN was supported by grants from the Whitehall Foundation (2004-05-90-APL), the March of Dimes Foundation (5-FY2006-281), the Muscular Dystrophy Association (92901), and the NINDS (NS053976)","month":"06","status":"public","quality_controlled":0,"publication":"PLoS Biology","_id":"1722","extern":1,"publist_id":"5408","issue":"6","intvolume":"         8","citation":{"short":"É. Dessaud, V. Ribes, N. Balaskas, L. Yang, A. Pierani, A. Kicheva, B. Novitch, J. Briscoe, N. Sasai, PLoS Biology 8 (2010).","chicago":"Dessaud, Éric, Vanessa Ribes, Nikolaos Balaskas, Linlin Yang, Alessandra Pierani, Anna Kicheva, Bennett Novitch, James Briscoe, and Noriaki Sasai. “Dynamic Assignment and Maintenance of Positional Identity in the Ventral Neural Tube by the Morphogen Sonic Hedgehog.” <i>PLoS Biology</i>. Public Library of Science, 2010. <a href=\"https://doi.org/10.1371/journal.pbio.1000382\">https://doi.org/10.1371/journal.pbio.1000382</a>.","ista":"Dessaud É, Ribes V, Balaskas N, Yang L, Pierani A, Kicheva A, Novitch B, Briscoe J, Sasai N. 2010. Dynamic assignment and maintenance of positional identity in the ventral neural tube by the morphogen sonic hedgehog. PLoS Biology. 8(6).","ama":"Dessaud É, Ribes V, Balaskas N, et al. Dynamic assignment and maintenance of positional identity in the ventral neural tube by the morphogen sonic hedgehog. <i>PLoS Biology</i>. 2010;8(6). doi:<a href=\"https://doi.org/10.1371/journal.pbio.1000382\">10.1371/journal.pbio.1000382</a>","apa":"Dessaud, É., Ribes, V., Balaskas, N., Yang, L., Pierani, A., Kicheva, A., … Sasai, N. (2010). Dynamic assignment and maintenance of positional identity in the ventral neural tube by the morphogen sonic hedgehog. <i>PLoS Biology</i>. Public Library of Science. <a href=\"https://doi.org/10.1371/journal.pbio.1000382\">https://doi.org/10.1371/journal.pbio.1000382</a>","mla":"Dessaud, Éric, et al. “Dynamic Assignment and Maintenance of Positional Identity in the Ventral Neural Tube by the Morphogen Sonic Hedgehog.” <i>PLoS Biology</i>, vol. 8, no. 6, Public Library of Science, 2010, doi:<a href=\"https://doi.org/10.1371/journal.pbio.1000382\">10.1371/journal.pbio.1000382</a>.","ieee":"É. Dessaud <i>et al.</i>, “Dynamic assignment and maintenance of positional identity in the ventral neural tube by the morphogen sonic hedgehog,” <i>PLoS Biology</i>, vol. 8, no. 6. Public Library of Science, 2010."},"doi":"10.1371/journal.pbio.1000382","publisher":"Public Library of Science","volume":8,"date_created":"2018-12-11T11:53:39Z","abstract":[{"text":"Morphogens are secreted signalling molecules that act in a graded manner to control the pattern of cellular differentiation in developing tissues. An example is Sonic hedgehog (Shh), which acts in several developing vertebrate tissues, including the central nervous system, to provide positional information during embryonic patterning. Here we address how Shh signalling assigns the positional identities of distinct neuronal subtype progenitors throughout the ventral neural tube. Assays of intracellular signal transduction and gene expression indicate that the duration as well as level of signalling is critical for morphogen interpretation. Progenitors of the ventral neuronal subtypes are established sequentially, with progressively more ventral identities requiring correspondingly higher levels and longer periods of Shh signalling. Moreover, cells remain sensitive to changes in Shh signalling for an extended time, reverting to antecedent identities if signalling levels fall below a threshold. Thus, the duration of signalling is important not only for the assignment but also for the refinement and maintenance of positional identity. Together the data suggest a dynamic model for ventral neural tube patterning in which positional information corresponds to the time integral of Shh signalling. This suggests an alternative to conventional models of morphogen action that rely solely on the level of signalling.","lang":"eng"}]},{"doi":"10.1038/nnano.2010.84","citation":{"ieee":"G. Katsaros <i>et al.</i>, “Hybrid superconductor-semiconductor devices made from self-assembled SiGe nanocrystals on silicon,” <i>Nature Nanotechnology</i>, vol. 5, no. 6. Nature Publishing Group, pp. 458–464, 2010.","mla":"Katsaros, Georgios, et al. “Hybrid Superconductor-Semiconductor Devices Made from Self-Assembled SiGe Nanocrystals on Silicon.” <i>Nature Nanotechnology</i>, vol. 5, no. 6, Nature Publishing Group, 2010, pp. 458–64, doi:<a href=\"https://doi.org/10.1038/nnano.2010.84\">10.1038/nnano.2010.84</a>.","ista":"Katsaros G, Spathis P, Stoffel M, Fournel F, Mongillo M, Bouchiat V, Lefloch F, Rastelli A, Schmidt O, De Franceschi S. 2010. Hybrid superconductor-semiconductor devices made from self-assembled SiGe nanocrystals on silicon. Nature Nanotechnology. 5(6), 458–464.","apa":"Katsaros, G., Spathis, P., Stoffel, M., Fournel, F., Mongillo, M., Bouchiat, V., … De Franceschi, S. (2010). Hybrid superconductor-semiconductor devices made from self-assembled SiGe nanocrystals on silicon. <i>Nature Nanotechnology</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/nnano.2010.84\">https://doi.org/10.1038/nnano.2010.84</a>","ama":"Katsaros G, Spathis P, Stoffel M, et al. Hybrid superconductor-semiconductor devices made from self-assembled SiGe nanocrystals on silicon. <i>Nature Nanotechnology</i>. 2010;5(6):458-464. doi:<a href=\"https://doi.org/10.1038/nnano.2010.84\">10.1038/nnano.2010.84</a>","chicago":"Katsaros, Georgios, Panayotis Spathis, Mathieu Stoffel, Frank Fournel, Massimo Mongillo, Vincent Bouchiat, François Lefloch, Armando Rastelli, Oliver Schmidt, and Silvano De Franceschi. “Hybrid Superconductor-Semiconductor Devices Made from Self-Assembled SiGe Nanocrystals on Silicon.” <i>Nature Nanotechnology</i>. Nature Publishing Group, 2010. <a href=\"https://doi.org/10.1038/nnano.2010.84\">https://doi.org/10.1038/nnano.2010.84</a>.","short":"G. Katsaros, P. Spathis, M. Stoffel, F. Fournel, M. Mongillo, V. Bouchiat, F. Lefloch, A. Rastelli, O. Schmidt, S. De Franceschi, Nature Nanotechnology 5 (2010) 458–464."},"intvolume":"         5","publisher":"Nature Publishing Group","volume":5,"abstract":[{"lang":"eng","text":"The epitaxial growth of germanium on silicon leads to the self-assembly of SiGe nanocrystals by a process that allows the size, composition and position of the nanocrystals to be controlled. This level of control, combined with an inherent compatibility with silicon technology, could prove useful in nanoelectronic applications. Here, we report the confinement of holes in quantum-dot devices made by directly contacting individual SiGe nanocrystals with aluminium electrodes, and the production of hybrid superconductor- semiconductor devices, such as resonant supercurrent transistors, when the quantum dot is strongly coupled to the electrodes. Charge transport measurements on weakly coupled quantum dots reveal discrete energy spectra, with the confined hole states displaying anisotropic gyromagnetic factors and strong spin-orbit coupling with pronounced dependences on gate voltage and magnetic field."}],"date_created":"2018-12-11T11:53:49Z","quality_controlled":0,"publication":"Nature Nanotechnology","month":"06","status":"public","main_file_link":[{"open_access":"1","url":"http://arxiv.org/abs/1005.1816"}],"_id":"1752","extern":1,"publist_id":"5372","issue":"6","oa":1,"type":"journal_article","page":"458 - 464","day":"01","acknowledgement":"We also acknowledge support from the Agence Nationale de la Recherche (through the ACCESS and COHESION projects). G.K. acknowledges further support from the Deutsche Forschungsgemeinschaft (grant no. KA 2922/1-1)","title":"Hybrid superconductor-semiconductor devices made from self-assembled SiGe nanocrystals on silicon","date_updated":"2021-01-12T06:52:59Z","date_published":"2010-06-01T00:00:00Z","author":[{"last_name":"Katsaros","first_name":"Georgios","id":"38DB5788-F248-11E8-B48F-1D18A9856A87","full_name":"Georgios Katsaros"},{"full_name":"Spathis, Panayotis N","last_name":"Spathis","first_name":"Panayotis"},{"full_name":"Stoffel, Mathieu","first_name":"Mathieu","last_name":"Stoffel"},{"full_name":"Fournel, Frank","first_name":"Frank","last_name":"Fournel"},{"full_name":"Mongillo, Massimo","first_name":"Massimo","last_name":"Mongillo"},{"full_name":"Bouchiat, Vincent","first_name":"Vincent","last_name":"Bouchiat"},{"first_name":"François","last_name":"Lefloch","full_name":"Lefloch, François"},{"last_name":"Rastelli","first_name":"Armando","full_name":"Rastelli, Armando"},{"full_name":"Schmidt, Oliver G","first_name":"Oliver","last_name":"Schmidt"},{"full_name":"De Franceschi, Silvano","last_name":"De Franceschi","first_name":"Silvano"}],"publication_status":"published","year":"2010"}]