---
_id: '3957'
author:
- first_name: Julia
  full_name: Riedl, Julia
  last_name: Riedl
- first_name: Kevin
  full_name: Flynn, Kevin C
  last_name: Flynn
- first_name: Aurelia
  full_name: Raducanu, Aurelia
  last_name: Raducanu
- first_name: Florian R
  full_name: Florian Gärtner
  id: 397A88EE-F248-11E8-B48F-1D18A9856A87
  last_name: Gärtner
  orcid: 0000-0001-6120-3723
- first_name: Gisela
  full_name: Beck, Gisela
  last_name: Beck
- first_name: Michael
  full_name: Bosl, Michael
  last_name: Bosl
- first_name: Frank
  full_name: Bradke, Frank
  last_name: Bradke
- first_name: Steffen
  full_name: Massberg, Steffen
  last_name: Massberg
- first_name: Attila
  full_name: Aszodi, Attila
  last_name: Aszodi
- first_name: Michael K
  full_name: Michael Sixt
  id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
  last_name: Sixt
  orcid: 0000-0002-6620-9179
- first_name: Roland
  full_name: Wedlich-Söldner, Roland
  last_name: Wedlich Söldner
citation:
  ama: Riedl J, Flynn K, Raducanu A, et al. Lifeact mice for studying F-actin dynamics.
    <i>Nature Methods</i>. 2010;7(3):168-169. doi:<a href="https://doi.org/10.1038/nmeth0310-168">10.1038/nmeth0310-168</a>
  apa: Riedl, J., Flynn, K., Raducanu, A., Gärtner, F. R., Beck, G., Bosl, M., … Wedlich
    Söldner, R. (2010). Lifeact mice for studying F-actin dynamics. <i>Nature Methods</i>.
    Nature Publishing Group. <a href="https://doi.org/10.1038/nmeth0310-168">https://doi.org/10.1038/nmeth0310-168</a>
  chicago: Riedl, Julia, Kevin Flynn, Aurelia Raducanu, Florian R Gärtner, Gisela
    Beck, Michael Bosl, Frank Bradke, et al. “Lifeact Mice for Studying F-Actin Dynamics.”
    <i>Nature Methods</i>. Nature Publishing Group, 2010. <a href="https://doi.org/10.1038/nmeth0310-168">https://doi.org/10.1038/nmeth0310-168</a>.
  ieee: J. Riedl <i>et al.</i>, “Lifeact mice for studying F-actin dynamics,” <i>Nature
    Methods</i>, vol. 7, no. 3. Nature Publishing Group, pp. 168–169, 2010.
  ista: Riedl J, Flynn K, Raducanu A, Gärtner FR, Beck G, Bosl M, Bradke F, Massberg
    S, Aszodi A, Sixt MK, Wedlich Söldner R. 2010. Lifeact mice for studying F-actin
    dynamics. Nature Methods. 7(3), 168–169.
  mla: Riedl, Julia, et al. “Lifeact Mice for Studying F-Actin Dynamics.” <i>Nature
    Methods</i>, vol. 7, no. 3, Nature Publishing Group, 2010, pp. 168–69, doi:<a
    href="https://doi.org/10.1038/nmeth0310-168">10.1038/nmeth0310-168</a>.
  short: J. Riedl, K. Flynn, A. Raducanu, F.R. Gärtner, G. Beck, M. Bosl, F. Bradke,
    S. Massberg, A. Aszodi, M.K. Sixt, R. Wedlich Söldner, Nature Methods 7 (2010)
    168–169.
date_created: 2018-12-11T12:06:06Z
date_published: 2010-03-01T00:00:00Z
date_updated: 2021-01-12T07:53:28Z
day: '01'
doi: 10.1038/nmeth0310-168
extern: 1
intvolume: '         7'
issue: '3'
month: '03'
page: 168 - 169
publication: Nature Methods
publication_status: published
publisher: Nature Publishing Group
publist_id: '2171'
quality_controlled: 0
status: public
title: Lifeact mice for studying F-actin dynamics
type: journal_article
volume: 7
year: '2010'
...
---
_id: '3958'
abstract:
- lang: eng
  text: Extracellular matrix (ECM) proteins can modify immune reactions, e.g. by sequestering
    or displaying growth factors and by interacting with immune and glial cells. Here
    we quantified by quantitative polymerase chain reaction (qPCR) expression of 50
    ECM components and 34 ECM degrading enzymes in multiple sclerosis (MS) active
    and inactive white matter lesions. COL1A1, COL3A1, COL5A1 and COL5A2 chains were
    induced strongly in active lesions and even more in inactive lesions. These chains
    interact to form collagen types I, III and V, which are fibrillar collagens. Biglycan
    and decorin, which can decorate fibrillar collagens, were also induced strongly.
    The fibrillar collagens, biglycan and decorin were largely found between the endothelium
    and astrocytic glia limitans in the perivascular space where they formed a meshwork
    which was closely associated with infiltrating immune cells. In active lesions
    collagen V was also seen in the heavily infiltrated parenchyma. Fibrillar collagens
    I and III inhibited in vitro human monocyte production of CCL2 (MCP-1), an inflammatory
    chemokine involved in recruitment of immune cells. Together, ECM changes in lesions
    with different activities were quantified and proteins forming a perivascular
    fibrosis were identified. Induced fibrillar collagens may contribute to limiting
    enlargement of MS lesions by inhibiting the production of CCL2 by monocytes.
author:
- first_name: Hema
  full_name: Mohan, Hema
  last_name: Mohan
- first_name: Markus
  full_name: Krumbholz, Markus
  last_name: Krumbholz
- first_name: Rakhi
  full_name: Sharma, Rakhi
  last_name: Sharma
- first_name: Sylvia
  full_name: Eisele, Sylvia
  last_name: Eisele
- first_name: Andreas
  full_name: Junker, Andreas
  last_name: Junker
- first_name: Michael K
  full_name: Michael Sixt
  id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
  last_name: Sixt
  orcid: 0000-0002-6620-9179
- first_name: Jia
  full_name: Newcombe, Jia
  last_name: Newcombe
- first_name: Hartmut
  full_name: Wekerle, Hartmut
  last_name: Wekerle
- first_name: Reinhard
  full_name: Hohlfeld, Reinhard
  last_name: Hohlfeld
- first_name: Hans
  full_name: Lassmann, Hans
  last_name: Lassmann
- first_name: Edgar
  full_name: Meinl, Edgar
  last_name: Meinl
citation:
  ama: 'Mohan H, Krumbholz M, Sharma R, et al. Extracellular matrix in multiple sclerosis
    lesions: fibrillar collagens, biglycan and decorin are upregulated and associated
    with infiltrating immune cells. <i>Brain Pathology</i>. 2010;20(5):966-975. doi:<a
    href="https://doi.org/10.1111/j.1750-3639.2010.00399.x">10.1111/j.1750-3639.2010.00399.x</a>'
  apa: 'Mohan, H., Krumbholz, M., Sharma, R., Eisele, S., Junker, A., Sixt, M. K.,
    … Meinl, E. (2010). Extracellular matrix in multiple sclerosis lesions: fibrillar
    collagens, biglycan and decorin are upregulated and associated with infiltrating
    immune cells. <i>Brain Pathology</i>. Wiley-Blackwell. <a href="https://doi.org/10.1111/j.1750-3639.2010.00399.x">https://doi.org/10.1111/j.1750-3639.2010.00399.x</a>'
  chicago: 'Mohan, Hema, Markus Krumbholz, Rakhi Sharma, Sylvia Eisele, Andreas Junker,
    Michael K Sixt, Jia Newcombe, et al. “Extracellular Matrix in Multiple Sclerosis
    Lesions: Fibrillar Collagens, Biglycan and Decorin Are Upregulated and Associated
    with Infiltrating Immune Cells.” <i>Brain Pathology</i>. Wiley-Blackwell, 2010.
    <a href="https://doi.org/10.1111/j.1750-3639.2010.00399.x">https://doi.org/10.1111/j.1750-3639.2010.00399.x</a>.'
  ieee: 'H. Mohan <i>et al.</i>, “Extracellular matrix in multiple sclerosis lesions:
    fibrillar collagens, biglycan and decorin are upregulated and associated with
    infiltrating immune cells,” <i>Brain Pathology</i>, vol. 20, no. 5. Wiley-Blackwell,
    pp. 966–975, 2010.'
  ista: 'Mohan H, Krumbholz M, Sharma R, Eisele S, Junker A, Sixt MK, Newcombe J,
    Wekerle H, Hohlfeld R, Lassmann H, Meinl E. 2010. Extracellular matrix in multiple
    sclerosis lesions: fibrillar collagens, biglycan and decorin are upregulated and
    associated with infiltrating immune cells. Brain Pathology. 20(5), 966–975.'
  mla: 'Mohan, Hema, et al. “Extracellular Matrix in Multiple Sclerosis Lesions: Fibrillar
    Collagens, Biglycan and Decorin Are Upregulated and Associated with Infiltrating
    Immune Cells.” <i>Brain Pathology</i>, vol. 20, no. 5, Wiley-Blackwell, 2010,
    pp. 966–75, doi:<a href="https://doi.org/10.1111/j.1750-3639.2010.00399.x">10.1111/j.1750-3639.2010.00399.x</a>.'
  short: H. Mohan, M. Krumbholz, R. Sharma, S. Eisele, A. Junker, M.K. Sixt, J. Newcombe,
    H. Wekerle, R. Hohlfeld, H. Lassmann, E. Meinl, Brain Pathology 20 (2010) 966–975.
date_created: 2018-12-11T12:06:07Z
date_published: 2010-09-01T00:00:00Z
date_updated: 2021-01-12T07:53:28Z
day: '01'
doi: 10.1111/j.1750-3639.2010.00399.x
extern: 1
intvolume: '        20'
issue: '5'
month: '09'
page: 966 - 975
publication: Brain Pathology
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2169'
quality_controlled: 0
status: public
title: 'Extracellular matrix in multiple sclerosis lesions: fibrillar collagens, biglycan
  and decorin are upregulated and associated with infiltrating immune cells'
type: journal_article
volume: 20
year: '2010'
...
---
_id: '3959'
abstract:
- lang: eng
  text: Chemokines orchestrate immune cell trafficking by eliciting either directed
    or random migration and by activating integrins in order to induce cell adhesion.
    Analyzing dendritic cell (DC) migration, we showed that these distinct cellular
    responses depended on the mode of chemokine presentation within tissues. The surface-immobilized
    form of the chemokine CCL21, the heparan sulfate-anchoring ligand of the CC-chemokine
    receptor 7 (CCR7), caused random movement of DCs that was confined to the chemokine-presenting
    surface because it triggered integrin-mediated adhesion. Upon direct contact with
    CCL21, DCs truncated the anchoring residues of CCL21, thereby releasing it from
    the solid phase. Soluble CCL21 functionally resembles the second CCR7 ligand,
    CCL19, which lacks anchoring residues and forms soluble gradients. Both soluble
    CCR7 ligands triggered chemotactic movement, but not surface adhesion. Adhesive
    random migration and directional steering cooperate to produce dynamic but spatially
    restricted locomotion patterns closely resembling the cellular dynamics observed
    in secondary lymphoid organs.
author:
- first_name: Kathrin
  full_name: Schumann, Kathrin
  id: F44D762E-4F9D-11E9-B64C-9EB26CEFFB5F
  last_name: Schumann
- first_name: Tim
  full_name: Lämmermann, Tim
  last_name: Lämmermann
- first_name: Markus
  full_name: Bruckner, Markus
  last_name: Bruckner
- first_name: Daniel
  full_name: Legler, Daniel
  last_name: Legler
- first_name: Julien
  full_name: Polleux, Julien
  last_name: Polleux
- first_name: Joachim
  full_name: Spatz, Joachim
  last_name: Spatz
- first_name: Gerold
  full_name: Schuler, Gerold
  last_name: Schuler
- first_name: Reinhold
  full_name: Förster, Reinhold
  last_name: Förster
- first_name: Manfred
  full_name: Lutz, Manfred
  last_name: Lutz
- first_name: Lydia
  full_name: Sorokin, Lydia
  last_name: Sorokin
- first_name: Michael K
  full_name: Sixt, Michael K
  id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
  last_name: Sixt
  orcid: 0000-0002-6620-9179
citation:
  ama: Schumann K, Lämmermann T, Bruckner M, et al. Immobilized chemokine fields and
    soluble chemokine gradients cooperatively shape migration patterns of dendritic
    cells. <i>Immunity</i>. 2010;32(5):703-713. doi:<a href="https://doi.org/10.1016/j.immuni.2010.04.017">10.1016/j.immuni.2010.04.017</a>
  apa: Schumann, K., Lämmermann, T., Bruckner, M., Legler, D., Polleux, J., Spatz,
    J., … Sixt, M. K. (2010). Immobilized chemokine fields and soluble chemokine gradients
    cooperatively shape migration patterns of dendritic cells. <i>Immunity</i>. Cell
    Press. <a href="https://doi.org/10.1016/j.immuni.2010.04.017">https://doi.org/10.1016/j.immuni.2010.04.017</a>
  chicago: Schumann, Kathrin, Tim Lämmermann, Markus Bruckner, Daniel Legler, Julien
    Polleux, Joachim Spatz, Gerold Schuler, et al. “Immobilized Chemokine Fields and
    Soluble Chemokine Gradients Cooperatively Shape Migration Patterns of Dendritic
    Cells.” <i>Immunity</i>. Cell Press, 2010. <a href="https://doi.org/10.1016/j.immuni.2010.04.017">https://doi.org/10.1016/j.immuni.2010.04.017</a>.
  ieee: K. Schumann <i>et al.</i>, “Immobilized chemokine fields and soluble chemokine
    gradients cooperatively shape migration patterns of dendritic cells,” <i>Immunity</i>,
    vol. 32, no. 5. Cell Press, pp. 703–713, 2010.
  ista: Schumann K, Lämmermann T, Bruckner M, Legler D, Polleux J, Spatz J, Schuler
    G, Förster R, Lutz M, Sorokin L, Sixt MK. 2010. Immobilized chemokine fields and
    soluble chemokine gradients cooperatively shape migration patterns of dendritic
    cells. Immunity. 32(5), 703–713.
  mla: Schumann, Kathrin, et al. “Immobilized Chemokine Fields and Soluble Chemokine
    Gradients Cooperatively Shape Migration Patterns of Dendritic Cells.” <i>Immunity</i>,
    vol. 32, no. 5, Cell Press, 2010, pp. 703–13, doi:<a href="https://doi.org/10.1016/j.immuni.2010.04.017">10.1016/j.immuni.2010.04.017</a>.
  short: K. Schumann, T. Lämmermann, M. Bruckner, D. Legler, J. Polleux, J. Spatz,
    G. Schuler, R. Förster, M. Lutz, L. Sorokin, M.K. Sixt, Immunity 32 (2010) 703–713.
date_created: 2018-12-11T12:06:07Z
date_published: 2010-05-28T00:00:00Z
date_updated: 2021-01-12T07:53:29Z
day: '28'
doi: 10.1016/j.immuni.2010.04.017
extern: '1'
intvolume: '        32'
issue: '5'
language:
- iso: eng
month: '05'
oa_version: None
page: 703 - 713
publication: Immunity
publication_status: published
publisher: Cell Press
publist_id: '2168'
status: public
title: Immobilized chemokine fields and soluble chemokine gradients cooperatively
  shape migration patterns of dendritic cells
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 32
year: '2010'
...
---
_id: '3960'
abstract:
- lang: eng
  text: When lymphocytes follow chemotactic cues, they can adopt different migratory
    modes depending on the geometry and molecular composition of their extracellular
    environment. In this issue of The EMBO Journal, Klemke et al (2010) describe a
    novel Ras-dependent chemokine receptor signalling pathway that leads to activation
    of cofilin, which in turn amplifies actin turnover. This signalling module is
    exclusively required for lymphocyte migration in three-dimensional (3D) environments,
    but not for locomotion on two-dimensional (2D) surfaces.
author:
- first_name: Michele
  full_name: Michele Weber
  id: 3A3FC708-F248-11E8-B48F-1D18A9856A87
  last_name: Weber
- first_name: Michael K
  full_name: Michael Sixt
  id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
  last_name: Sixt
  orcid: 0000-0002-6620-9179
citation:
  ama: Weber M, Sixt MK. MEK signalling tunes actin treadmilling for interstitial
    lymphocyte migration. <i>EMBO Journal</i>. 2010;29(17):2861-2863. doi:<a href="https://doi.org/10.1038/emboj.2010.183">10.1038/emboj.2010.183</a>
  apa: Weber, M., &#38; Sixt, M. K. (2010). MEK signalling tunes actin treadmilling
    for interstitial lymphocyte migration. <i>EMBO Journal</i>. Wiley-Blackwell. <a
    href="https://doi.org/10.1038/emboj.2010.183">https://doi.org/10.1038/emboj.2010.183</a>
  chicago: Weber, Michele, and Michael K Sixt. “MEK Signalling Tunes Actin Treadmilling
    for Interstitial Lymphocyte Migration.” <i>EMBO Journal</i>. Wiley-Blackwell,
    2010. <a href="https://doi.org/10.1038/emboj.2010.183">https://doi.org/10.1038/emboj.2010.183</a>.
  ieee: M. Weber and M. K. Sixt, “MEK signalling tunes actin treadmilling for interstitial
    lymphocyte migration,” <i>EMBO Journal</i>, vol. 29, no. 17. Wiley-Blackwell,
    pp. 2861–2863, 2010.
  ista: Weber M, Sixt MK. 2010. MEK signalling tunes actin treadmilling for interstitial
    lymphocyte migration. EMBO Journal. 29(17), 2861–2863.
  mla: Weber, Michele, and Michael K. Sixt. “MEK Signalling Tunes Actin Treadmilling
    for Interstitial Lymphocyte Migration.” <i>EMBO Journal</i>, vol. 29, no. 17,
    Wiley-Blackwell, 2010, pp. 2861–63, doi:<a href="https://doi.org/10.1038/emboj.2010.183">10.1038/emboj.2010.183</a>.
  short: M. Weber, M.K. Sixt, EMBO Journal 29 (2010) 2861–2863.
date_created: 2018-12-11T12:06:07Z
date_published: 2010-09-01T00:00:00Z
date_updated: 2021-01-12T07:53:29Z
day: '01'
doi: 10.1038/emboj.2010.183
extern: 1
intvolume: '        29'
issue: '17'
main_file_link:
- open_access: '1'
  url: http://www.ncbi.nlm.nih.gov/pmc/issues/190105/
month: '09'
oa: 1
page: 2861 - 2863
publication: EMBO Journal
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2167'
quality_controlled: 0
status: public
title: MEK signalling tunes actin treadmilling for interstitial lymphocyte migration
type: journal_article
volume: 29
year: '2010'
...
---
_id: '3961'
abstract:
- lang: eng
  text: For innate and adaptive immune responses it is essential that inflammatory
    cells use quick and flexible locomotion strategies. Accordingly, most leukocytes
    can efficiently infiltrate and traverse almost every physiological or artificial
    environment. Here, we review how leukocytes might achieve this task mechanistically,
    and summarize recent findings on the principles of cytoskeletal force generation
    and transduction at the leading edge of leukocytes. We propose a model in which
    the cells switch between adhesion-receptor-mediated force transmission and locomotion
    modes that are based on cellular deformations, but independent of adhesion receptors.
    This plasticity in migration strategies allows leukocytes to adapt to the geometry
    and molecular composition of their environment.
acknowledgement: We are grateful to Michele Weber for critical comments on the manuscript.
  Work in the laboratory of M.S. is supported by the German Research Foundation, the
  Peter Hans Hofschneider Foundation for Experimental Biomedicine and the Max Planck
  Society. J.R. is supported by a PhD fellowship of the Böhringer Ingelheim Fond.
  We thank Reinhard Fässler and Stefan Jentsch for their continuous support.
author:
- first_name: Jörg
  full_name: Jörg Renkawitz
  id: 3F0587C8-F248-11E8-B48F-1D18A9856A87
  last_name: Renkawitz
  orcid: 0000-0003-2856-3369
- first_name: Michael K
  full_name: Michael Sixt
  id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
  last_name: Sixt
  orcid: 0000-0002-6620-9179
citation:
  ama: Renkawitz J, Sixt MK. Mechanisms of force generation and force transmission
    during interstitial leukocyte migration. <i>EMBO Reports</i>. 2010;11(10):744-750.
    doi:<a href="https://doi.org/10.1038/embor.2010.147">10.1038/embor.2010.147</a>
  apa: Renkawitz, J., &#38; Sixt, M. K. (2010). Mechanisms of force generation and
    force transmission during interstitial leukocyte migration. <i>EMBO Reports</i>.
    Wiley-Blackwell. <a href="https://doi.org/10.1038/embor.2010.147">https://doi.org/10.1038/embor.2010.147</a>
  chicago: Renkawitz, Jörg, and Michael K Sixt. “Mechanisms of Force Generation and
    Force Transmission during Interstitial Leukocyte Migration.” <i>EMBO Reports</i>.
    Wiley-Blackwell, 2010. <a href="https://doi.org/10.1038/embor.2010.147">https://doi.org/10.1038/embor.2010.147</a>.
  ieee: J. Renkawitz and M. K. Sixt, “Mechanisms of force generation and force transmission
    during interstitial leukocyte migration,” <i>EMBO Reports</i>, vol. 11, no. 10.
    Wiley-Blackwell, pp. 744–750, 2010.
  ista: Renkawitz J, Sixt MK. 2010. Mechanisms of force generation and force transmission
    during interstitial leukocyte migration. EMBO Reports. 11(10), 744–750.
  mla: Renkawitz, Jörg, and Michael K. Sixt. “Mechanisms of Force Generation and Force
    Transmission during Interstitial Leukocyte Migration.” <i>EMBO Reports</i>, vol.
    11, no. 10, Wiley-Blackwell, 2010, pp. 744–50, doi:<a href="https://doi.org/10.1038/embor.2010.147">10.1038/embor.2010.147</a>.
  short: J. Renkawitz, M.K. Sixt, EMBO Reports 11 (2010) 744–750.
date_created: 2018-12-11T12:06:08Z
date_published: 2010-09-24T00:00:00Z
date_updated: 2021-01-12T07:53:30Z
day: '24'
doi: 10.1038/embor.2010.147
extern: 1
intvolume: '        11'
issue: '10'
month: '09'
page: 744 - 750
publication: EMBO Reports
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2166'
quality_controlled: 0
status: public
title: Mechanisms of force generation and force transmission during interstitial leukocyte
  migration
type: journal_article
volume: 11
year: '2010'
...
---
OA_place: publisher
_id: '3962'
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Holger
  full_name: Pflicke, Holger
  id: CAA57A9A-5B61-11E9-B130-E0C1E1F2C83D
  last_name: Pflicke
citation:
  ama: Pflicke H.   Dendritic cell migration across basement membranes in the skin.
    2010.
  apa: Pflicke, H. (2010). <i>  Dendritic cell migration across basement membranes
    in the skin</i>. Institute of Science and Technology Austria.
  chicago: Pflicke, Holger. “  Dendritic Cell Migration across Basement Membranes
    in the Skin.” Institute of Science and Technology Austria, 2010.
  ieee: H. Pflicke, “  Dendritic cell migration across basement membranes in the skin,”
    Institute of Science and Technology Austria, 2010.
  ista: Pflicke H. 2010.   Dendritic cell migration across basement membranes in the
    skin. Institute of Science and Technology Austria.
  mla: Pflicke, Holger. <i>  Dendritic Cell Migration across Basement Membranes in
    the Skin</i>. Institute of Science and Technology Austria, 2010.
  short: H. Pflicke,   Dendritic Cell Migration across Basement Membranes in the Skin,
    Institute of Science and Technology Austria, 2010.
corr_author: '1'
date_created: 2018-12-11T12:06:08Z
date_published: 2010-07-01T00:00:00Z
date_updated: 2026-04-09T14:37:07Z
day: '01'
degree_awarded: PhD
department:
- _id: CaHe
- _id: GradSch
language:
- iso: eng
month: '07'
oa_version: None
publication_identifier:
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
publist_id: '2165'
status: public
supervisor:
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
title: "\uFEFF\uFEFFDendritic cell migration across basement membranes in the skin"
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2010'
...
---
_id: '3963'
abstract:
- lang: eng
  text: Almost all species of the orchid genus Ophrys are pollinated by sexual deception.
    The orchids mimic the sex pheromone of receptive female insects, mainly hymenopterans,
    in order to attract males seeking to copulate. Most Ophrys species have achromatic
    flowers, but some exhibit a coloured perianth and a bright, conspicuous labellum
    pattern. We recently showed that the pink perianth of Ophrys heldreichii flowers
    increases detectability by its pollinator, males of the long-horned bee Eucera
    berlandi. Here we tested the hypothesis that the bright, complex labellum pattern
    mimics the female of the pollinator to increase attractiveness toward males. In
    a dual-choice test we offered E. berlandi males an O. heldreichii flower and a
    flower from O. dictynnae, which also exhibits a pinkish perianth but no conspicuous
    labellum pattern. Both flowers were housed in UV-transmitting acrylic glass boxes
    to exclude olfactory signals. Males significantly preferred O. heldreichii to
    O. dictynnae flowers. In a second experiment, we replaced the perianth of both
    flowers with identical artificial perianths made from pink card, so that only
    the labellum differed between the two flower stimuli. Males then chose between
    both stimuli at random, suggesting that the presence of a labellum pattern does
    not affect their choice. Spectral measurements revealed higher colour contrast
    with the background of the perianth of O. heldreichii compared to O. dictynnae,
    but no difference in green receptor-specific contrast or brightness. Our results
    show that male choice is guided by the chromatic contrast of the perianth during
    the initial flower approach but is not affected by the presence of a labellum
    pattern. Instead, we hypothesise that the labellum pattern is involved in aversive
    learning during post-copulatory behaviour and used by the orchid as a strategy
    to increase outcrossing.
article_processing_charge: No
author:
- first_name: M.
  full_name: Streinzer, M.
  last_name: Streinzer
- first_name: Thomas
  full_name: Ellis, Thomas
  id: 3153D6D4-F248-11E8-B48F-1D18A9856A87
  last_name: Ellis
  orcid: 0000-0002-8511-0254
- first_name: H.
  full_name: Paulus, H.
  last_name: Paulus
- first_name: J.
  full_name: Spaethe, J.
  last_name: Spaethe
citation:
  ama: Streinzer M, Ellis T, Paulus H, Spaethe J. Visual discrimination between two
    sexually deceptive Ophrys species by a bee pollinator. <i>Arthropod-Plant Interactions</i>.
    2010;4(3):141-148. doi:<a href="https://doi.org/10.1007/s11829-010-9093-4">10.1007/s11829-010-9093-4</a>
  apa: Streinzer, M., Ellis, T., Paulus, H., &#38; Spaethe, J. (2010). Visual discrimination
    between two sexually deceptive Ophrys species by a bee pollinator. <i>Arthropod-Plant
    Interactions</i>. Springer. <a href="https://doi.org/10.1007/s11829-010-9093-4">https://doi.org/10.1007/s11829-010-9093-4</a>
  chicago: Streinzer, M., Thomas Ellis, H. Paulus, and J. Spaethe. “Visual Discrimination
    between Two Sexually Deceptive Ophrys Species by a Bee Pollinator.” <i>Arthropod-Plant
    Interactions</i>. Springer, 2010. <a href="https://doi.org/10.1007/s11829-010-9093-4">https://doi.org/10.1007/s11829-010-9093-4</a>.
  ieee: M. Streinzer, T. Ellis, H. Paulus, and J. Spaethe, “Visual discrimination
    between two sexually deceptive Ophrys species by a bee pollinator,” <i>Arthropod-Plant
    Interactions</i>, vol. 4, no. 3. Springer, pp. 141–148, 2010.
  ista: Streinzer M, Ellis T, Paulus H, Spaethe J. 2010. Visual discrimination between
    two sexually deceptive Ophrys species by a bee pollinator. Arthropod-Plant Interactions.
    4(3), 141–148.
  mla: Streinzer, M., et al. “Visual Discrimination between Two Sexually Deceptive
    Ophrys Species by a Bee Pollinator.” <i>Arthropod-Plant Interactions</i>, vol.
    4, no. 3, Springer, 2010, pp. 141–48, doi:<a href="https://doi.org/10.1007/s11829-010-9093-4">10.1007/s11829-010-9093-4</a>.
  short: M. Streinzer, T. Ellis, H. Paulus, J. Spaethe, Arthropod-Plant Interactions
    4 (2010) 141–148.
date_created: 2018-12-11T12:06:08Z
date_published: 2010-01-01T00:00:00Z
date_updated: 2021-01-12T07:53:30Z
day: '01'
doi: 10.1007/s11829-010-9093-4
extern: '1'
intvolume: '         4'
issue: '3'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc/4.0/
month: '01'
oa_version: None
page: 141 - 148
publication: Arthropod-Plant Interactions
publication_status: published
publisher: Springer
publist_id: '2164'
status: public
title: Visual discrimination between two sexually deceptive Ophrys species by a bee
  pollinator
tmp:
  image: /images/cc_by_nc.png
  legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
  short: CC BY-NC (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 4
year: '2010'
...
---
_id: '3964'
abstract:
- lang: eng
  text: We prove two stability results for Lipschitz functions on triangulable, compact
    metric spaces and consider applications of both to problems in systems biology.
    Given two functions, the first result is formulated in terms of the Wasserstein
    distance between their persistence diagrams and the second in terms of their total
    persistence.
acknowledgement: This research is partially supported by the Defense Advanced Research
  Projects Agency (DARPA) under grants HR0011-05-1-0007 and HR0011-05-1-0057 and by
  CNRS under grant PICS-3416.
author:
- first_name: David
  full_name: Cohen-Steiner, David
  last_name: Cohen Steiner
- first_name: Herbert
  full_name: Herbert Edelsbrunner
  id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
  last_name: Edelsbrunner
  orcid: 0000-0002-9823-6833
- first_name: John
  full_name: Harer, John
  last_name: Harer
- first_name: Yuriy
  full_name: Mileyko, Yuriy
  last_name: Mileyko
citation:
  ama: Cohen Steiner D, Edelsbrunner H, Harer J, Mileyko Y. Lipschitz functions have
    L_p-stable persistence. <i>Foundations of Computational Mathematics</i>. 2010;10(2):127-139.
    doi:<a href="https://doi.org/10.1007/s10208-010-9060-6">10.1007/s10208-010-9060-6</a>
  apa: Cohen Steiner, D., Edelsbrunner, H., Harer, J., &#38; Mileyko, Y. (2010). Lipschitz
    functions have L_p-stable persistence. <i>Foundations of Computational Mathematics</i>.
    Springer. <a href="https://doi.org/10.1007/s10208-010-9060-6">https://doi.org/10.1007/s10208-010-9060-6</a>
  chicago: Cohen Steiner, David, Herbert Edelsbrunner, John Harer, and Yuriy Mileyko.
    “Lipschitz Functions Have L_p-Stable Persistence.” <i>Foundations of Computational
    Mathematics</i>. Springer, 2010. <a href="https://doi.org/10.1007/s10208-010-9060-6">https://doi.org/10.1007/s10208-010-9060-6</a>.
  ieee: D. Cohen Steiner, H. Edelsbrunner, J. Harer, and Y. Mileyko, “Lipschitz functions
    have L_p-stable persistence,” <i>Foundations of Computational Mathematics</i>,
    vol. 10, no. 2. Springer, pp. 127–139, 2010.
  ista: Cohen Steiner D, Edelsbrunner H, Harer J, Mileyko Y. 2010. Lipschitz functions
    have L_p-stable persistence. Foundations of Computational Mathematics. 10(2),
    127–139.
  mla: Cohen Steiner, David, et al. “Lipschitz Functions Have L_p-Stable Persistence.”
    <i>Foundations of Computational Mathematics</i>, vol. 10, no. 2, Springer, 2010,
    pp. 127–39, doi:<a href="https://doi.org/10.1007/s10208-010-9060-6">10.1007/s10208-010-9060-6</a>.
  short: D. Cohen Steiner, H. Edelsbrunner, J. Harer, Y. Mileyko, Foundations of Computational
    Mathematics 10 (2010) 127–139.
date_created: 2018-12-11T12:06:09Z
date_published: 2010-01-28T00:00:00Z
date_updated: 2021-01-12T07:53:31Z
day: '28'
doi: 10.1007/s10208-010-9060-6
extern: 1
intvolume: '        10'
issue: '2'
month: '01'
page: 127 - 139
publication: Foundations of Computational Mathematics
publication_status: published
publisher: Springer
publist_id: '2163'
quality_controlled: 0
status: public
title: Lipschitz functions have L_p-stable persistence
type: journal_article
volume: 10
year: '2010'
...
---
_id: '4134'
abstract:
- lang: eng
  text: 'All species are restricted in their distribution. Currently, ecological models
    can only explain such limits if patches vary in quality, leading to asymmetrical
    dispersal, or if genetic variation is too low at the margins for adaptation. However,
    population genetic models suggest that the increase in genetic variance resulting
    from dispersal should allow adaptation to almost any ecological gradient. Clearly
    therefore, these models miss something that prevents evolution in natural populations.
    We developed an individual-based simulation to explore stochastic effects in these
    models. At high carrying capacities, our simulations largely agree with deterministic
    predictions. However, when carrying capacity is low, the population fails to establish
    for a wide range of parameter values where adaptation was expected from previous
    models. Stochastic or transient effects appear critical around the boundaries
    in parameter space between simulation behaviours. Dispersal, gradient steepness,
    and population density emerge as key factors determining adaptation on an ecological
    gradient. '
acknowledgement: We are very grateful to Nick Barton.
article_processing_charge: No
author:
- first_name: Jon
  full_name: Bridle, Jon
  last_name: Bridle
- first_name: Jitka
  full_name: Polechova, Jitka
  id: 3BBFB084-F248-11E8-B48F-1D18A9856A87
  last_name: Polechova
  orcid: 0000-0003-0951-3112
- first_name: Masakado
  full_name: Kawata, Masakado
  last_name: Kawata
- first_name: Roger
  full_name: Butlin, Roger
  last_name: Butlin
citation:
  ama: Bridle J, Polechova J, Kawata M, Butlin R. Why is adaptation prevented at ecological
    margins? New insights from individual-based simulations. <i>Ecology Letters</i>.
    2010;13(4):485-494. doi:<a href="https://doi.org/10.1111/j.1461-0248.2010.01442.x">10.1111/j.1461-0248.2010.01442.x</a>
  apa: Bridle, J., Polechova, J., Kawata, M., &#38; Butlin, R. (2010). Why is adaptation
    prevented at ecological margins? New insights from individual-based simulations.
    <i>Ecology Letters</i>. Wiley-Blackwell. <a href="https://doi.org/10.1111/j.1461-0248.2010.01442.x">https://doi.org/10.1111/j.1461-0248.2010.01442.x</a>
  chicago: Bridle, Jon, Jitka Polechova, Masakado Kawata, and Roger Butlin. “Why Is
    Adaptation Prevented at Ecological Margins? New Insights from Individual-Based
    Simulations.” <i>Ecology Letters</i>. Wiley-Blackwell, 2010. <a href="https://doi.org/10.1111/j.1461-0248.2010.01442.x">https://doi.org/10.1111/j.1461-0248.2010.01442.x</a>.
  ieee: J. Bridle, J. Polechova, M. Kawata, and R. Butlin, “Why is adaptation prevented
    at ecological margins? New insights from individual-based simulations,” <i>Ecology
    Letters</i>, vol. 13, no. 4. Wiley-Blackwell, pp. 485–494, 2010.
  ista: Bridle J, Polechova J, Kawata M, Butlin R. 2010. Why is adaptation prevented
    at ecological margins? New insights from individual-based simulations. Ecology
    Letters. 13(4), 485–494.
  mla: Bridle, Jon, et al. “Why Is Adaptation Prevented at Ecological Margins? New
    Insights from Individual-Based Simulations.” <i>Ecology Letters</i>, vol. 13,
    no. 4, Wiley-Blackwell, 2010, pp. 485–94, doi:<a href="https://doi.org/10.1111/j.1461-0248.2010.01442.x">10.1111/j.1461-0248.2010.01442.x</a>.
  short: J. Bridle, J. Polechova, M. Kawata, R. Butlin, Ecology Letters 13 (2010)
    485–494.
date_created: 2018-12-11T12:07:08Z
date_published: 2010-03-15T00:00:00Z
date_updated: 2025-09-30T09:29:55Z
day: '15'
department:
- _id: NiBa
doi: 10.1111/j.1461-0248.2010.01442.x
ec_funded: 1
external_id:
  isi:
  - '000275635400008'
intvolume: '        13'
isi: 1
issue: '4'
language:
- iso: eng
month: '03'
oa_version: None
page: 485 - 494
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '291734'
  name: International IST Postdoc Fellowship Programme
publication: Ecology Letters
publication_status: published
publisher: Wiley-Blackwell
publist_id: '1987'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Why is adaptation prevented at ecological margins? New insights from individual-based
  simulations
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 13
year: '2010'
...
---
_id: '4157'
abstract:
- lang: eng
  text: Integrin- and cadherin-mediated adhesion is central for cell and tissue morphogenesis,
    allowing cells and tissues to change shape without loosing integrity. Studies
    predominantly in cell culture showed that mechanosensation through adhesion structures
    is achieved by force-mediated modulation of their molecular composition. The specific
    molecular composition of adhesion sites in turn determines their signalling activity
    and dynamic reorganization. Here, we will review how adhesion sites respond to
    mecanical stimuli, and how spatially and temporally regulated signalling from
    different adhesion sites controls cell migration and tissue morphogenesis.
acknowledged_ssus:
- _id: Bio
article_processing_charge: No
author:
- first_name: Ekaterina
  full_name: Papusheva, Ekaterina
  id: 41DB591E-F248-11E8-B48F-1D18A9856A87
  last_name: Papusheva
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
citation:
  ama: 'Papusheva E, Heisenberg C-PJ. Spatial organization of adhesion: force-dependent
    regulation and function in tissue morphogenesis. <i>EMBO Journal</i>. 2010;29(16):2753-2768.
    doi:<a href="https://doi.org/10.1038/emboj.2010.182">10.1038/emboj.2010.182</a>'
  apa: 'Papusheva, E., &#38; Heisenberg, C.-P. J. (2010). Spatial organization of
    adhesion: force-dependent regulation and function in tissue morphogenesis. <i>EMBO
    Journal</i>. Wiley-Blackwell. <a href="https://doi.org/10.1038/emboj.2010.182">https://doi.org/10.1038/emboj.2010.182</a>'
  chicago: 'Papusheva, Ekaterina, and Carl-Philipp J Heisenberg. “Spatial Organization
    of Adhesion: Force-Dependent Regulation and Function in Tissue Morphogenesis.”
    <i>EMBO Journal</i>. Wiley-Blackwell, 2010. <a href="https://doi.org/10.1038/emboj.2010.182">https://doi.org/10.1038/emboj.2010.182</a>.'
  ieee: 'E. Papusheva and C.-P. J. Heisenberg, “Spatial organization of adhesion:
    force-dependent regulation and function in tissue morphogenesis,” <i>EMBO Journal</i>,
    vol. 29, no. 16. Wiley-Blackwell, pp. 2753–2768, 2010.'
  ista: 'Papusheva E, Heisenberg C-PJ. 2010. Spatial organization of adhesion: force-dependent
    regulation and function in tissue morphogenesis. EMBO Journal. 29(16), 2753–2768.'
  mla: 'Papusheva, Ekaterina, and Carl-Philipp J. Heisenberg. “Spatial Organization
    of Adhesion: Force-Dependent Regulation and Function in Tissue Morphogenesis.”
    <i>EMBO Journal</i>, vol. 29, no. 16, Wiley-Blackwell, 2010, pp. 2753–68, doi:<a
    href="https://doi.org/10.1038/emboj.2010.182">10.1038/emboj.2010.182</a>.'
  short: E. Papusheva, C.-P.J. Heisenberg, EMBO Journal 29 (2010) 2753–2768.
date_created: 2018-12-11T12:07:17Z
date_published: 2010-08-18T00:00:00Z
date_updated: 2025-09-30T09:29:30Z
day: '18'
department:
- _id: Bio
- _id: CaHe
doi: 10.1038/emboj.2010.182
external_id:
  isi:
  - '000281006400009'
  pmid:
  - '20717145'
intvolume: '        29'
isi: 1
issue: '16'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924654/
month: '08'
oa: 1
oa_version: Submitted Version
page: 2753 - 2768
pmid: 1
publication: EMBO Journal
publication_status: published
publisher: Wiley-Blackwell
publist_id: '1962'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Spatial organization of adhesion: force-dependent regulation and function
  in tissue morphogenesis'
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 29
year: '2010'
...
---
_id: '4163'
abstract:
- lang: eng
  text: Organ formation requires the precise assembly of progenitor cells into a functional
    multicellular structure. Mechanical forces probably participate in this process
    but how they influence organ morphogenesis is still unclear. Here, we show that
    Wnt11- and Prickle1a-mediated planar cell polarity (PCP) signalling coordinates
    the formation of the zebrafish ciliated laterality organ (Kupffer's vesicle) by
    regulating adhesion properties between organ progenitor cells (the dorsal forerunner
    cells, DFCs). Combined inhibition of Wnt11 and Prickle1a reduces DFC cell-cell
    adhesion and impairs their compaction and arrangement during vesicle lumen formation.
    This leads to the formation of a mis-shapen vesicle with small fragmented lumina
    and shortened cilia, resulting in severely impaired organ function and, as a consequence,
    randomised laterality of both molecular and visceral asymmetries. Our results
    reveal a novel role for PCP-dependent cell adhesion in coordinating the supracellular
    organisation of progenitor cells during vertebrate laterality organ formation.
article_processing_charge: No
author:
- first_name: Pablo
  full_name: Oteíza, Pablo
  last_name: Oteíza
- first_name: Mathias
  full_name: Koeppen, Mathias
  last_name: Koeppen
- first_name: Michael
  full_name: Krieg, Michael
  last_name: Krieg
- first_name: Eduardo
  full_name: Pulgar, Eduardo
  last_name: Pulgar
- first_name: Cecilia
  full_name: Farias, Cecilia
  last_name: Farias
- first_name: Cristina
  full_name: Melo, Cristina
  last_name: Melo
- first_name: Steffen
  full_name: Preibisch, Steffen
  last_name: Preibisch
- first_name: Daniel
  full_name: Mueller, Daniel
  last_name: Mueller
- first_name: Masazumi
  full_name: Tada, Masazumi
  last_name: Tada
- first_name: Steffen
  full_name: Hartel, Steffen
  last_name: Hartel
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
- first_name: Miguel
  full_name: Concha, Miguel
  last_name: Concha
citation:
  ama: Oteíza P, Koeppen M, Krieg M, et al. Planar cell polarity signalling regulates
    cell adhesion properties in progenitors of the zebrafish laterality organ. <i>Development</i>.
    2010;137(20):3459-3468. doi:<a href="https://doi.org/10.1242/dev.049981">10.1242/dev.049981</a>
  apa: Oteíza, P., Koeppen, M., Krieg, M., Pulgar, E., Farias, C., Melo, C., … Concha,
    M. (2010). Planar cell polarity signalling regulates cell adhesion properties
    in progenitors of the zebrafish laterality organ. <i>Development</i>. Company
    of Biologists. <a href="https://doi.org/10.1242/dev.049981">https://doi.org/10.1242/dev.049981</a>
  chicago: Oteíza, Pablo, Mathias Koeppen, Michael Krieg, Eduardo Pulgar, Cecilia
    Farias, Cristina Melo, Steffen Preibisch, et al. “Planar Cell Polarity Signalling
    Regulates Cell Adhesion Properties in Progenitors of the Zebrafish Laterality
    Organ.” <i>Development</i>. Company of Biologists, 2010. <a href="https://doi.org/10.1242/dev.049981">https://doi.org/10.1242/dev.049981</a>.
  ieee: P. Oteíza <i>et al.</i>, “Planar cell polarity signalling regulates cell adhesion
    properties in progenitors of the zebrafish laterality organ,” <i>Development</i>,
    vol. 137, no. 20. Company of Biologists, pp. 3459–3468, 2010.
  ista: Oteíza P, Koeppen M, Krieg M, Pulgar E, Farias C, Melo C, Preibisch S, Mueller
    D, Tada M, Hartel S, Heisenberg C-PJ, Concha M. 2010. Planar cell polarity signalling
    regulates cell adhesion properties in progenitors of the zebrafish laterality
    organ. Development. 137(20), 3459–3468.
  mla: Oteíza, Pablo, et al. “Planar Cell Polarity Signalling Regulates Cell Adhesion
    Properties in Progenitors of the Zebrafish Laterality Organ.” <i>Development</i>,
    vol. 137, no. 20, Company of Biologists, 2010, pp. 3459–68, doi:<a href="https://doi.org/10.1242/dev.049981">10.1242/dev.049981</a>.
  short: P. Oteíza, M. Koeppen, M. Krieg, E. Pulgar, C. Farias, C. Melo, S. Preibisch,
    D. Mueller, M. Tada, S. Hartel, C.-P.J. Heisenberg, M. Concha, Development 137
    (2010) 3459–3468.
date_created: 2018-12-11T12:07:20Z
date_published: 2010-10-15T00:00:00Z
date_updated: 2021-01-12T07:54:58Z
day: '15'
doi: 10.1242/dev.049981
extern: '1'
intvolume: '       137'
issue: '20'
language:
- iso: eng
month: '10'
oa_version: None
page: 3459 - 3468
publication: Development
publication_status: published
publisher: Company of Biologists
publist_id: '1958'
status: public
title: Planar cell polarity signalling regulates cell adhesion properties in progenitors
  of the zebrafish laterality organ
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 137
year: '2010'
...
---
_id: '4187'
abstract:
- lang: eng
  text: Cell migration is central to embryonic development, homeostasis and disease(1),
    processes in which cells move as part of a group or individually. Whereas the
    mechanisms controlling single-cell migration in vitro are relatively well understood(2-4),
    less is known about the mechanisms promoting the motility of individual cells
    in vivo. In particular, it is not clear how cells that form blebs in their migration
    use those protrusions to bring about movement in the context of the three-dimensional
    cellular environment(5,6). Here we show that the motility of chemokine-guided
    germ cells within the zebrafish embryo requires the function of the small Rho
    GTPases Rac1 and RhoA, as well as E-cadherin-mediated cell-cell adhesion. Using
    fluorescence resonance energy transfer we demonstrate that Rac1 and RhoA are activated
    in the cell front. At this location, Rac1 is responsible for the formation of
    actin-rich structures, and RhoA promotes retrograde actin flow. We propose that
    these actin-rich structures undergoing retrograde flow are essential for the generation
    of E-cadherin-mediated traction forces between the germ cells and the surrounding
    tissue and are therefore crucial for cell motility in vivo.
author:
- first_name: Elena
  full_name: Kardash, Elena
  last_name: Kardash
- first_name: Michal
  full_name: Reichman-Fried, Michal
  last_name: Reichman Fried
- first_name: Jean
  full_name: Maître, Jean-Léon
  last_name: Maître
- first_name: Bijan
  full_name: Boldajipour, Bijan
  last_name: Boldajipour
- first_name: Ekaterina
  full_name: Ekaterina Papusheva
  id: 41DB591E-F248-11E8-B48F-1D18A9856A87
  last_name: Papusheva
- first_name: Esther
  full_name: Messerschmidt, Esther-Maria
  last_name: Messerschmidt
- first_name: Carl
  full_name: Heisenberg, Carl-Philipp
  last_name: Heisenberg
- first_name: Erez
  full_name: Raz, Erez
  last_name: Raz
citation:
  ama: Kardash E, Reichman Fried M, Maître J, et al. A role for Rho GTPases and cell-cell
    adhesion in single-cell motility in vivo. <i>Nature Cell Biology</i>. 2010;12(1):47-53.
    doi:<a href="https://doi.org/10.1038/ncb2003">10.1038/ncb2003</a>
  apa: Kardash, E., Reichman Fried, M., Maître, J., Boldajipour, B., Papusheva, E.,
    Messerschmidt, E., … Raz, E. (2010). A role for Rho GTPases and cell-cell adhesion
    in single-cell motility in vivo. <i>Nature Cell Biology</i>. Nature Publishing
    Group. <a href="https://doi.org/10.1038/ncb2003">https://doi.org/10.1038/ncb2003</a>
  chicago: Kardash, Elena, Michal Reichman Fried, Jean Maître, Bijan Boldajipour,
    Ekaterina Papusheva, Esther Messerschmidt, Carl Heisenberg, and Erez Raz. “A Role
    for Rho GTPases and Cell-Cell Adhesion in Single-Cell Motility in Vivo.” <i>Nature
    Cell Biology</i>. Nature Publishing Group, 2010. <a href="https://doi.org/10.1038/ncb2003">https://doi.org/10.1038/ncb2003</a>.
  ieee: E. Kardash <i>et al.</i>, “A role for Rho GTPases and cell-cell adhesion in
    single-cell motility in vivo,” <i>Nature Cell Biology</i>, vol. 12, no. 1. Nature
    Publishing Group, pp. 47–53, 2010.
  ista: Kardash E, Reichman Fried M, Maître J, Boldajipour B, Papusheva E, Messerschmidt
    E, Heisenberg C, Raz E. 2010. A role for Rho GTPases and cell-cell adhesion in
    single-cell motility in vivo. Nature Cell Biology. 12(1), 47–53.
  mla: Kardash, Elena, et al. “A Role for Rho GTPases and Cell-Cell Adhesion in Single-Cell
    Motility in Vivo.” <i>Nature Cell Biology</i>, vol. 12, no. 1, Nature Publishing
    Group, 2010, pp. 47–53, doi:<a href="https://doi.org/10.1038/ncb2003">10.1038/ncb2003</a>.
  short: E. Kardash, M. Reichman Fried, J. Maître, B. Boldajipour, E. Papusheva, E.
    Messerschmidt, C. Heisenberg, E. Raz, Nature Cell Biology 12 (2010) 47–53.
date_created: 2018-12-11T12:07:28Z
date_published: 2010-01-01T00:00:00Z
date_updated: 2021-01-12T07:55:09Z
day: '01'
doi: 10.1038/ncb2003
extern: 1
intvolume: '        12'
issue: '1'
month: '01'
page: 47 - 53
publication: Nature Cell Biology
publication_status: published
publisher: Nature Publishing Group
publist_id: '1932'
quality_controlled: 0
status: public
title: A role for Rho GTPases and cell-cell adhesion in single-cell motility in vivo
type: journal_article
volume: 12
year: '2010'
...
---
_id: '4221'
abstract:
- lang: eng
  text: Collective cell migration, the simultaneous movement of multiple cells that
    are connected by cell-cell adhesion, is ubiquitous in development, tissue repair,
    and tumor metastasis [1, 2]. It has been hypothesized that the directionality
    of cell movement during collective migration emerges as a collective property
    [3, 4]. Here we determine how movement directionality is established in collective
    mesendoderm migration during zebrafish gastrulation. By interfering with two key
    features of collective migration, (1) having neighboring cells and (2) adhering
    to them, we show that individual mesendoderm cells are capable of normal directed
    migration when moving as single cells but require cell-cell adhesion to participate
    in coordinated and directed migration when moving as part of a group. We conclude
    that movement directionality is not a de novo collective property of mesendoderm
    cells but rather a property of single mesendoderm cells that requires cell-cell
    adhesion during collective migration.
article_processing_charge: No
author:
- first_name: Yohanna
  full_name: Arboleda Estudillo, Yohanna
  last_name: Arboleda Estudillo
- first_name: Michael
  full_name: Krieg, Michael
  last_name: Krieg
- first_name: Jan
  full_name: Stuehmer, Jan
  last_name: Stuehmer
- first_name: Nicholas
  full_name: Licata, Nicholas
  last_name: Licata
- first_name: Daniel
  full_name: Mueller, Daniel
  last_name: Mueller
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
citation:
  ama: Arboleda Estudillo Y, Krieg M, Stuehmer J, Licata N, Mueller D, Heisenberg
    C-PJ. Movement directionality in collective migration of germ layer progenitors.
    <i>Current Biology</i>. 2010;20(2):161-169. doi:<a href="https://doi.org/10.1016/j.cub.2009.11.036">10.1016/j.cub.2009.11.036</a>
  apa: Arboleda Estudillo, Y., Krieg, M., Stuehmer, J., Licata, N., Mueller, D., &#38;
    Heisenberg, C.-P. J. (2010). Movement directionality in collective migration of
    germ layer progenitors. <i>Current Biology</i>. Cell Press. <a href="https://doi.org/10.1016/j.cub.2009.11.036">https://doi.org/10.1016/j.cub.2009.11.036</a>
  chicago: Arboleda Estudillo, Yohanna, Michael Krieg, Jan Stuehmer, Nicholas Licata,
    Daniel Mueller, and Carl-Philipp J Heisenberg. “Movement Directionality in Collective
    Migration of Germ Layer Progenitors.” <i>Current Biology</i>. Cell Press, 2010.
    <a href="https://doi.org/10.1016/j.cub.2009.11.036">https://doi.org/10.1016/j.cub.2009.11.036</a>.
  ieee: Y. Arboleda Estudillo, M. Krieg, J. Stuehmer, N. Licata, D. Mueller, and C.-P.
    J. Heisenberg, “Movement directionality in collective migration of germ layer
    progenitors,” <i>Current Biology</i>, vol. 20, no. 2. Cell Press, pp. 161–169,
    2010.
  ista: Arboleda Estudillo Y, Krieg M, Stuehmer J, Licata N, Mueller D, Heisenberg
    C-PJ. 2010. Movement directionality in collective migration of germ layer progenitors.
    Current Biology. 20(2), 161–169.
  mla: Arboleda Estudillo, Yohanna, et al. “Movement Directionality in Collective
    Migration of Germ Layer Progenitors.” <i>Current Biology</i>, vol. 20, no. 2,
    Cell Press, 2010, pp. 161–69, doi:<a href="https://doi.org/10.1016/j.cub.2009.11.036">10.1016/j.cub.2009.11.036</a>.
  short: Y. Arboleda Estudillo, M. Krieg, J. Stuehmer, N. Licata, D. Mueller, C.-P.J.
    Heisenberg, Current Biology 20 (2010) 161–169.
date_created: 2018-12-11T12:07:40Z
date_published: 2010-01-26T00:00:00Z
date_updated: 2021-01-12T07:55:25Z
day: '26'
doi: 10.1016/j.cub.2009.11.036
extern: '1'
intvolume: '        20'
issue: '2'
language:
- iso: eng
month: '01'
oa_version: None
page: 161 - 169
publication: Current Biology
publication_status: published
publisher: Cell Press
publist_id: '1897'
status: public
title: Movement directionality in collective migration of germ layer progenitors
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 20
year: '2010'
...
---
_id: '4243'
abstract:
- lang: eng
  text: We investigate a new model for populations evolving in a spatial continuum.
    This model can be thought of as a spatial version of the Lambda-Fleming-Viot process.
    It explicitly incorporates both small scale reproduction events and large scale
    extinction-recolonisation events. The lineages ancestral to a sample from a population
    evolving according to this model can be described in terms of a spatial version
    of the Lambda-coalescent. Using a technique of Evans (1997), we prove existence
    and uniqueness in law for the model. We then investigate the asymptotic behaviour
    of the genealogy of a finite number of individuals sampled uniformly at random
    (or more generally `far enough apart') from a two-dimensional torus of sidelength
    L as L tends to infinity. Under appropriate conditions (and on a suitable timescale)
    we can obtain as limiting genealogical processes a Kingman coalescent, a more
    general Lambda-coalescent or a system of coalescing Brownian motions (with a non-local
    coalescence mechanism).
article_processing_charge: No
author:
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
- first_name: Alison
  full_name: Etheridge, Alison
  last_name: Etheridge
- first_name: Amandine
  full_name: Véber, Amandine
  last_name: Véber
citation:
  ama: Barton NH, Etheridge A, Véber A. A new model for evolution in a spatial continuum.
    <i>Electronic Journal of Probability</i>. 2010;15(7):162-216. doi:<a href="https://doi.org/10.1214/EJP.v15-741">10.1214/EJP.v15-741</a>
  apa: Barton, N. H., Etheridge, A., &#38; Véber, A. (2010). A new model for evolution
    in a spatial continuum. <i>Electronic Journal of Probability</i>. Institute of
    Mathematical Statistics. <a href="https://doi.org/10.1214/EJP.v15-741">https://doi.org/10.1214/EJP.v15-741</a>
  chicago: Barton, Nicholas H, Alison Etheridge, and Amandine Véber. “A New Model
    for Evolution in a Spatial Continuum.” <i>Electronic Journal of Probability</i>.
    Institute of Mathematical Statistics, 2010. <a href="https://doi.org/10.1214/EJP.v15-741">https://doi.org/10.1214/EJP.v15-741</a>.
  ieee: N. H. Barton, A. Etheridge, and A. Véber, “A new model for evolution in a
    spatial continuum,” <i>Electronic Journal of Probability</i>, vol. 15, no. 7.
    Institute of Mathematical Statistics, pp. 162–216, 2010.
  ista: Barton NH, Etheridge A, Véber A. 2010. A new model for evolution in a spatial
    continuum. Electronic Journal of Probability. 15(7), 162–216.
  mla: Barton, Nicholas H., et al. “A New Model for Evolution in a Spatial Continuum.”
    <i>Electronic Journal of Probability</i>, vol. 15, no. 7, Institute of Mathematical
    Statistics, 2010, pp. 162–216, doi:<a href="https://doi.org/10.1214/EJP.v15-741">10.1214/EJP.v15-741</a>.
  short: N.H. Barton, A. Etheridge, A. Véber, Electronic Journal of Probability 15
    (2010) 162–216.
date_created: 2018-12-11T12:07:48Z
date_published: 2010-02-03T00:00:00Z
date_updated: 2025-09-30T09:28:54Z
day: '03'
ddc:
- '576'
department:
- _id: NiBa
doi: 10.1214/EJP.v15-741
external_id:
  isi:
  - '000274822400001'
file:
- access_level: open_access
  checksum: bab577546dd4e8f882e9a9dd645cd01e
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:15:21Z
  date_updated: 2020-07-14T12:46:26Z
  file_id: '5140'
  file_name: IST-2015-369-v1+1_741-2535-1-PB.pdf
  file_size: 450171
  relation: main_file
file_date_updated: 2020-07-14T12:46:26Z
has_accepted_license: '1'
intvolume: '        15'
isi: 1
issue: '7'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '02'
oa: 1
oa_version: Published Version
page: 162 - 216
publication: Electronic Journal of Probability
publication_status: published
publisher: Institute of Mathematical Statistics
publist_id: '1863'
pubrep_id: '369'
quality_controlled: '1'
scopus_import: '1'
status: public
title: A new model for evolution in a spatial continuum
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 15
year: '2010'
...
---
_id: '4339'
abstract:
- lang: ger
  text: Mit diesem Buch möchten wir einen Überblick der aktuellen Diskussion zum Thema
    Bibliothek 2.0 geben und den Stand der tatsächlichen Umsetzung der Web 2.0-Ansätze
    in deutschsprachigen Bibliotheken beleuchten. An dieser Stelle ist die Frage erlaubt,
    warum es zu einer Zeit, in der es bereits die ersten "Web 3.0"- Konferenzen gibt,
    eines Handbuches der Bibliothek 2.0 noch bedarf. Und warum es überhaupt ein deutschsprachiges
    Handbuch zur Bibliothek 2.0 braucht, wo es doch bereits verschiedenste Publikationen
    zu diesem Thema aus anderen Ländern, insbesondere des angloamerikanischen Raums
    gibt. Ist dazu nicht bereits alles gesagt?
article_processing_charge: No
author:
- first_name: Julia
  full_name: Bergmann, Julia
  last_name: Bergmann
- first_name: Patrick
  full_name: Danowski, Patrick
  id: 2EBD1598-F248-11E8-B48F-1D18A9856A87
  last_name: Danowski
  orcid: 0000-0002-6026-4409
citation:
  ama: 'Bergmann J, Danowski P. Ist Bibliothek 2.0 überhaupt noch relevant? – Eine
    Einleitung in das Handbuch. In: Bergmann J, Danowski P, eds. <i>Handbuch Bibliothek
    2.0</i>. Bibliotheks- und Informationspraxis 41. De Gruyter; 2010:5-20. doi:<a
    href="https://doi.org/10.1515/9783110232103">10.1515/9783110232103</a>'
  apa: Bergmann, J., &#38; Danowski, P. (2010). Ist Bibliothek 2.0 überhaupt noch
    relevant? – Eine Einleitung in das Handbuch. In J. Bergmann &#38; P. Danowski
    (Eds.), <i>Handbuch Bibliothek 2.0</i> (pp. 5–20). De Gruyter. <a href="https://doi.org/10.1515/9783110232103">https://doi.org/10.1515/9783110232103</a>
  chicago: Bergmann, Julia, and Patrick Danowski. “Ist Bibliothek 2.0 Überhaupt Noch
    Relevant? – Eine Einleitung in Das Handbuch.” In <i>Handbuch Bibliothek 2.0</i>,
    edited by Julia Bergmann and Patrick Danowski, 5–20. Bibliotheks- Und Informationspraxis
    41. De Gruyter, 2010. <a href="https://doi.org/10.1515/9783110232103">https://doi.org/10.1515/9783110232103</a>.
  ieee: J. Bergmann and P. Danowski, “Ist Bibliothek 2.0 überhaupt noch relevant?
    – Eine Einleitung in das Handbuch,” in <i>Handbuch Bibliothek 2.0</i>, J. Bergmann
    and P. Danowski, Eds. De Gruyter, 2010, pp. 5–20.
  ista: 'Bergmann J, Danowski P. 2010.Ist Bibliothek 2.0 überhaupt noch relevant?
    – Eine Einleitung in das Handbuch. In: Handbuch Bibliothek 2.0. , 5–20.'
  mla: Bergmann, Julia, and Patrick Danowski. “Ist Bibliothek 2.0 Überhaupt Noch Relevant?
    – Eine Einleitung in Das Handbuch.” <i>Handbuch Bibliothek 2.0</i>, edited by
    Julia Bergmann and Patrick Danowski, De Gruyter, 2010, pp. 5–20, doi:<a href="https://doi.org/10.1515/9783110232103">10.1515/9783110232103</a>.
  short: J. Bergmann, P. Danowski, in:, J. Bergmann, P. Danowski (Eds.), Handbuch
    Bibliothek 2.0, De Gruyter, 2010, pp. 5–20.
date_created: 2018-12-11T12:08:21Z
date_published: 2010-09-23T00:00:00Z
date_updated: 2025-07-02T11:25:10Z
day: '23'
ddc:
- '020'
doi: 10.1515/9783110232103
editor:
- first_name: Julia
  full_name: Bergmann, Julia
  last_name: Bergmann
- first_name: Patrick
  full_name: Danowski, Patrick
  id: 2EBD1598-F248-11E8-B48F-1D18A9856A87
  last_name: Danowski
  orcid: 0000-0002-6026-4409
extern: '1'
file:
- access_level: open_access
  checksum: d42cedd48fffa85d75046f396a309fc3
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:15:06Z
  date_updated: 2020-07-14T12:46:27Z
  file_id: '5123'
  file_name: IST-2012-12-v1+1_9783110232103.5.pdf
  file_size: 567580
  relation: main_file
file_date_updated: 2020-07-14T12:46:27Z
has_accepted_license: '1'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: 5 - 20
publication: Handbuch Bibliothek 2.0
publication_status: published
publisher: De Gruyter
publist_id: '1235'
pubrep_id: '12'
quality_controlled: '1'
series_title: Bibliotheks- und Informationspraxis 41
status: public
title: Ist Bibliothek 2.0 überhaupt noch relevant? – Eine Einleitung in das Handbuch
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: book_chapter
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2010'
...
---
_id: '4340'
abstract:
- lang: eng
  text: "More and more libraries starting semantic web projects. The question about
    the license of the data\r\nis not discussed or the discussion is deferred to the
    end of project. in this paper is discussed why\r\nthe question of the license
    is so important in context of the semantic web that is should be one of the\r\nfirst
    aspects in a semantic web project. Also it will be shown why a public domain weaver
    is the\r\nonly solution that fulfill the the special requirements of the semantic
    web and that guaranties the\r\nreuseablitly of semantic library data for a sustainability
    of the projects. "
author:
- first_name: Patrick
  full_name: Danowski, Patrick
  id: 2EBD1598-F248-11E8-B48F-1D18A9856A87
  last_name: Danowski
  orcid: 0000-0002-6026-4409
citation:
  ama: Danowski P. <i>Open Bibliographic Data</i>. Elsevier; 2010.
  apa: Danowski, P. (2010). <i>Open bibliographic data</i>. <i>European Library Automation
    Group (ELAG) 2010</i>. Elsevier.
  chicago: Danowski, Patrick. <i>Open Bibliographic Data</i>. <i>European Library
    Automation Group (ELAG) 2010</i>. Elsevier, 2010.
  ieee: P. Danowski, <i>Open bibliographic data</i>. Elsevier, 2010.
  ista: Danowski P. 2010. Open bibliographic data, Elsevier,p.
  mla: Danowski, Patrick. “Open Bibliographic Data.” <i>European Library Automation
    Group (ELAG) 2010</i>, Elsevier, 2010.
  short: P. Danowski, Open Bibliographic Data, Elsevier, 2010.
conference:
  name: 'ELAG: European Library Automation Group'
date_created: 2018-12-11T12:08:21Z
date_published: 2010-06-10T00:00:00Z
date_updated: 2020-07-14T23:07:19Z
day: '10'
ddc:
- '020'
extern: '1'
file:
- access_level: open_access
  checksum: 7061756135333d73b26a84526fa654f5
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:15:01Z
  date_updated: 2020-07-14T12:46:27Z
  file_id: '5118'
  file_name: IST-2012-51-v1+1_149-danowski-en.pdf
  file_size: 94982
  relation: main_file
file_date_updated: 2020-07-14T12:46:27Z
has_accepted_license: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://www.slideshare.net/PatrickD/open-bibliographic-data-elag2010
month: '06'
oa: 1
oa_version: None
publication: European Library Automation Group (ELAG) 2010
publication_status: published
publisher: Elsevier
publist_id: '1234'
status: public
title: Open bibliographic data
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: other_academic_publication
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2010'
...
---
_id: '4341'
abstract:
- lang: eng
  text: More and more libraries starting semantic web projects. The question about
    the license of the data is not discussed or the discussion is deferred to the
    end of project. in this paper is discussed why the question of the license is
    so important in context of the semantic web that is should be one of the first
    aspects in a semantic web project. Also it will be shown why a public domain weaver
    is the only solution that fulfill the the special requirements of the semantic
    web and that guaranties the reuseablitly of semantic library data for a sustainability
    of the projects.
alternative_title:
- 'IFLA '
author:
- first_name: Patrick
  full_name: Patrick Danowski
  id: 2EBD1598-F248-11E8-B48F-1D18A9856A87
  last_name: Danowski
  orcid: 0000-0002-6026-4409
citation:
  ama: 'Danowski P. Step one: blow up the silo! - Open bibliographic data, the first
    step towards Linked Open Data. In: IFLA; 2010.'
  apa: 'Danowski, P. (2010). Step one: blow up the silo! - Open bibliographic data,
    the first step towards Linked Open Data. Presented at the WLIC: World Library
    and Information Congress, IFLA.'
  chicago: 'Danowski, Patrick. “Step One: Blow up the Silo! - Open Bibliographic Data,
    the First Step towards Linked Open Data.” IFLA, 2010.'
  ieee: 'P. Danowski, “Step one: blow up the silo! - Open bibliographic data, the
    first step towards Linked Open Data,” presented at the WLIC: World Library and
    Information Congress, 2010.'
  ista: 'Danowski P. 2010. Step one: blow up the silo! - Open bibliographic data,
    the first step towards Linked Open Data. WLIC: World Library and Information Congress,
    IFLA , .'
  mla: 'Danowski, Patrick. <i>Step One: Blow up the Silo! - Open Bibliographic Data,
    the First Step towards Linked Open Data</i>. IFLA, 2010.'
  short: P. Danowski, in:, IFLA, 2010.
conference:
  name: 'WLIC: World Library and Information Congress'
date_created: 2018-12-11T12:08:21Z
date_published: 2010-08-01T00:00:00Z
date_updated: 2021-01-12T07:56:16Z
day: '01'
extern: 1
main_file_link:
- open_access: '0'
  url: http://www.ifla.org/files/hq/papers/ifla76/149-danowski-en.pdf
month: '08'
publication_status: published
publisher: IFLA
publist_id: '1233'
pubrep_id: '51'
quality_controlled: 0
status: public
title: 'Step one: blow up the silo! - Open bibliographic data, the first step towards
  Linked Open Data'
type: conference
year: '2010'
...
---
_id: '1721'
acknowledgement: AK is funded by a Marie Curie fellowship. JB is funded by the MRC
  (UK). The funders had no role in study design, data collection and analysis, decision
  to publish, or preparation of the manuscript
author:
- first_name: Anna
  full_name: Anna Kicheva
  id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
  last_name: Kicheva
  orcid: 0000-0003-4509-4998
- first_name: James
  full_name: Briscoe, James
  last_name: Briscoe
citation:
  ama: Kicheva A, Briscoe J. Limbs made to measure. <i>PLoS Biology</i>. 2010;8(7).
    doi:<a href="https://doi.org/10.1371/journal.pbio.1000421">10.1371/journal.pbio.1000421</a>
  apa: Kicheva, A., &#38; Briscoe, J. (2010). Limbs made to measure. <i>PLoS Biology</i>.
    Public Library of Science. <a href="https://doi.org/10.1371/journal.pbio.1000421">https://doi.org/10.1371/journal.pbio.1000421</a>
  chicago: Kicheva, Anna, and James Briscoe. “Limbs Made to Measure.” <i>PLoS Biology</i>.
    Public Library of Science, 2010. <a href="https://doi.org/10.1371/journal.pbio.1000421">https://doi.org/10.1371/journal.pbio.1000421</a>.
  ieee: A. Kicheva and J. Briscoe, “Limbs made to measure,” <i>PLoS Biology</i>, vol.
    8, no. 7. Public Library of Science, 2010.
  ista: Kicheva A, Briscoe J. 2010. Limbs made to measure. PLoS Biology. 8(7).
  mla: Kicheva, Anna, and James Briscoe. “Limbs Made to Measure.” <i>PLoS Biology</i>,
    vol. 8, no. 7, Public Library of Science, 2010, doi:<a href="https://doi.org/10.1371/journal.pbio.1000421">10.1371/journal.pbio.1000421</a>.
  short: A. Kicheva, J. Briscoe, PLoS Biology 8 (2010).
date_created: 2018-12-11T11:53:39Z
date_published: 2010-07-01T00:00:00Z
date_updated: 2021-01-12T06:52:45Z
day: '01'
doi: 10.1371/journal.pbio.1000421
extern: 1
intvolume: '         8'
issue: '7'
month: '07'
publication: PLoS Biology
publication_status: published
publisher: Public Library of Science
publist_id: '5407'
quality_controlled: 0
status: public
title: Limbs made to measure
type: journal_article
volume: 8
year: '2010'
...
---
_id: '1722'
abstract:
- lang: eng
  text: Morphogens are secreted signalling molecules that act in a graded manner to
    control the pattern of cellular differentiation in developing tissues. An example
    is Sonic hedgehog (Shh), which acts in several developing vertebrate tissues,
    including the central nervous system, to provide positional information during
    embryonic patterning. Here we address how Shh signalling assigns the positional
    identities of distinct neuronal subtype progenitors throughout the ventral neural
    tube. Assays of intracellular signal transduction and gene expression indicate
    that the duration as well as level of signalling is critical for morphogen interpretation.
    Progenitors of the ventral neuronal subtypes are established sequentially, with
    progressively more ventral identities requiring correspondingly higher levels
    and longer periods of Shh signalling. Moreover, cells remain sensitive to changes
    in Shh signalling for an extended time, reverting to antecedent identities if
    signalling levels fall below a threshold. Thus, the duration of signalling is
    important not only for the assignment but also for the refinement and maintenance
    of positional identity. Together the data suggest a dynamic model for ventral
    neural tube patterning in which positional information corresponds to the time
    integral of Shh signalling. This suggests an alternative to conventional models
    of morphogen action that rely solely on the level of signalling.
acknowledgement: 'NS was supported by a Marie Curie Fellowship (PIIF-GA-2008-219939)
  and the Mochida Memorial Foundation for Medical and Pharmaceutical Research. Support
  for VR was provided by an EMBO LTF, for AK by a FEBS LTF. ED was supported by the
  Wellcome Trust (#080630). Work in the lab of JB is supported by the Medical Research
  Council (UK). AP is a CNRS (Centre National de la Recherche Scientifique) Investigator.
  This work was supported by grants from the Ministère de la Recherche (ACI Grant
  #0220575) and the Association pour la Recherche sur le Cancer (Grant #4679) to AP.
  BGN was supported by grants from the Whitehall Foundation (2004-05-90-APL), the
  March of Dimes Foundation (5-FY2006-281), the Muscular Dystrophy Association (92901),
  and the NINDS (NS053976)'
author:
- first_name: Éric
  full_name: Dessaud, Éric
  last_name: Dessaud
- first_name: Vanessa
  full_name: Ribes, Vanessa
  last_name: Ribes
- first_name: Nikolaos
  full_name: Balaskas, Nikolaos
  last_name: Balaskas
- first_name: Linlin
  full_name: Yang, Linlin
  last_name: Yang
- first_name: Alessandra
  full_name: Pierani, Alessandra
  last_name: Pierani
- first_name: Anna
  full_name: Anna Kicheva
  id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
  last_name: Kicheva
  orcid: 0000-0003-4509-4998
- first_name: Bennett
  full_name: Novitch, Bennett
  last_name: Novitch
- first_name: James
  full_name: Briscoe, James
  last_name: Briscoe
- first_name: Noriaki
  full_name: Sasai, Noriaki
  last_name: Sasai
citation:
  ama: Dessaud É, Ribes V, Balaskas N, et al. Dynamic assignment and maintenance of
    positional identity in the ventral neural tube by the morphogen sonic hedgehog.
    <i>PLoS Biology</i>. 2010;8(6). doi:<a href="https://doi.org/10.1371/journal.pbio.1000382">10.1371/journal.pbio.1000382</a>
  apa: Dessaud, É., Ribes, V., Balaskas, N., Yang, L., Pierani, A., Kicheva, A., …
    Sasai, N. (2010). Dynamic assignment and maintenance of positional identity in
    the ventral neural tube by the morphogen sonic hedgehog. <i>PLoS Biology</i>.
    Public Library of Science. <a href="https://doi.org/10.1371/journal.pbio.1000382">https://doi.org/10.1371/journal.pbio.1000382</a>
  chicago: Dessaud, Éric, Vanessa Ribes, Nikolaos Balaskas, Linlin Yang, Alessandra
    Pierani, Anna Kicheva, Bennett Novitch, James Briscoe, and Noriaki Sasai. “Dynamic
    Assignment and Maintenance of Positional Identity in the Ventral Neural Tube by
    the Morphogen Sonic Hedgehog.” <i>PLoS Biology</i>. Public Library of Science,
    2010. <a href="https://doi.org/10.1371/journal.pbio.1000382">https://doi.org/10.1371/journal.pbio.1000382</a>.
  ieee: É. Dessaud <i>et al.</i>, “Dynamic assignment and maintenance of positional
    identity in the ventral neural tube by the morphogen sonic hedgehog,” <i>PLoS
    Biology</i>, vol. 8, no. 6. Public Library of Science, 2010.
  ista: Dessaud É, Ribes V, Balaskas N, Yang L, Pierani A, Kicheva A, Novitch B, Briscoe
    J, Sasai N. 2010. Dynamic assignment and maintenance of positional identity in
    the ventral neural tube by the morphogen sonic hedgehog. PLoS Biology. 8(6).
  mla: Dessaud, Éric, et al. “Dynamic Assignment and Maintenance of Positional Identity
    in the Ventral Neural Tube by the Morphogen Sonic Hedgehog.” <i>PLoS Biology</i>,
    vol. 8, no. 6, Public Library of Science, 2010, doi:<a href="https://doi.org/10.1371/journal.pbio.1000382">10.1371/journal.pbio.1000382</a>.
  short: É. Dessaud, V. Ribes, N. Balaskas, L. Yang, A. Pierani, A. Kicheva, B. Novitch,
    J. Briscoe, N. Sasai, PLoS Biology 8 (2010).
date_created: 2018-12-11T11:53:39Z
date_published: 2010-06-01T00:00:00Z
date_updated: 2021-01-12T06:52:46Z
day: '01'
doi: 10.1371/journal.pbio.1000382
extern: 1
intvolume: '         8'
issue: '6'
month: '06'
publication: PLoS Biology
publication_status: published
publisher: Public Library of Science
publist_id: '5408'
quality_controlled: 0
status: public
title: Dynamic assignment and maintenance of positional identity in the ventral neural
  tube by the morphogen sonic hedgehog
type: journal_article
volume: 8
year: '2010'
...
---
_id: '1752'
abstract:
- lang: eng
  text: The epitaxial growth of germanium on silicon leads to the self-assembly of
    SiGe nanocrystals by a process that allows the size, composition and position
    of the nanocrystals to be controlled. This level of control, combined with an
    inherent compatibility with silicon technology, could prove useful in nanoelectronic
    applications. Here, we report the confinement of holes in quantum-dot devices
    made by directly contacting individual SiGe nanocrystals with aluminium electrodes,
    and the production of hybrid superconductor- semiconductor devices, such as resonant
    supercurrent transistors, when the quantum dot is strongly coupled to the electrodes.
    Charge transport measurements on weakly coupled quantum dots reveal discrete energy
    spectra, with the confined hole states displaying anisotropic gyromagnetic factors
    and strong spin-orbit coupling with pronounced dependences on gate voltage and
    magnetic field.
acknowledgement: We also acknowledge support from the Agence Nationale de la Recherche
  (through the ACCESS and COHESION projects). G.K. acknowledges further support from
  the Deutsche Forschungsgemeinschaft (grant no. KA 2922/1-1)
author:
- first_name: Georgios
  full_name: Georgios Katsaros
  id: 38DB5788-F248-11E8-B48F-1D18A9856A87
  last_name: Katsaros
- first_name: Panayotis
  full_name: Spathis, Panayotis N
  last_name: Spathis
- first_name: Mathieu
  full_name: Stoffel, Mathieu
  last_name: Stoffel
- first_name: Frank
  full_name: Fournel, Frank
  last_name: Fournel
- first_name: Massimo
  full_name: Mongillo, Massimo
  last_name: Mongillo
- first_name: Vincent
  full_name: Bouchiat, Vincent
  last_name: Bouchiat
- first_name: François
  full_name: Lefloch, François
  last_name: Lefloch
- first_name: Armando
  full_name: Rastelli, Armando
  last_name: Rastelli
- first_name: Oliver
  full_name: Schmidt, Oliver G
  last_name: Schmidt
- first_name: Silvano
  full_name: De Franceschi, Silvano
  last_name: De Franceschi
citation:
  ama: Katsaros G, Spathis P, Stoffel M, et al. Hybrid superconductor-semiconductor
    devices made from self-assembled SiGe nanocrystals on silicon. <i>Nature Nanotechnology</i>.
    2010;5(6):458-464. doi:<a href="https://doi.org/10.1038/nnano.2010.84">10.1038/nnano.2010.84</a>
  apa: Katsaros, G., Spathis, P., Stoffel, M., Fournel, F., Mongillo, M., Bouchiat,
    V., … De Franceschi, S. (2010). Hybrid superconductor-semiconductor devices made
    from self-assembled SiGe nanocrystals on silicon. <i>Nature Nanotechnology</i>.
    Nature Publishing Group. <a href="https://doi.org/10.1038/nnano.2010.84">https://doi.org/10.1038/nnano.2010.84</a>
  chicago: Katsaros, Georgios, Panayotis Spathis, Mathieu Stoffel, Frank Fournel,
    Massimo Mongillo, Vincent Bouchiat, François Lefloch, Armando Rastelli, Oliver
    Schmidt, and Silvano De Franceschi. “Hybrid Superconductor-Semiconductor Devices
    Made from Self-Assembled SiGe Nanocrystals on Silicon.” <i>Nature Nanotechnology</i>.
    Nature Publishing Group, 2010. <a href="https://doi.org/10.1038/nnano.2010.84">https://doi.org/10.1038/nnano.2010.84</a>.
  ieee: G. Katsaros <i>et al.</i>, “Hybrid superconductor-semiconductor devices made
    from self-assembled SiGe nanocrystals on silicon,” <i>Nature Nanotechnology</i>,
    vol. 5, no. 6. Nature Publishing Group, pp. 458–464, 2010.
  ista: Katsaros G, Spathis P, Stoffel M, Fournel F, Mongillo M, Bouchiat V, Lefloch
    F, Rastelli A, Schmidt O, De Franceschi S. 2010. Hybrid superconductor-semiconductor
    devices made from self-assembled SiGe nanocrystals on silicon. Nature Nanotechnology.
    5(6), 458–464.
  mla: Katsaros, Georgios, et al. “Hybrid Superconductor-Semiconductor Devices Made
    from Self-Assembled SiGe Nanocrystals on Silicon.” <i>Nature Nanotechnology</i>,
    vol. 5, no. 6, Nature Publishing Group, 2010, pp. 458–64, doi:<a href="https://doi.org/10.1038/nnano.2010.84">10.1038/nnano.2010.84</a>.
  short: G. Katsaros, P. Spathis, M. Stoffel, F. Fournel, M. Mongillo, V. Bouchiat,
    F. Lefloch, A. Rastelli, O. Schmidt, S. De Franceschi, Nature Nanotechnology 5
    (2010) 458–464.
date_created: 2018-12-11T11:53:49Z
date_published: 2010-06-01T00:00:00Z
date_updated: 2021-01-12T06:52:59Z
day: '01'
doi: 10.1038/nnano.2010.84
extern: 1
intvolume: '         5'
issue: '6'
main_file_link:
- open_access: '1'
  url: http://arxiv.org/abs/1005.1816
month: '06'
oa: 1
page: 458 - 464
publication: Nature Nanotechnology
publication_status: published
publisher: Nature Publishing Group
publist_id: '5372'
quality_controlled: 0
status: public
title: Hybrid superconductor-semiconductor devices made from self-assembled SiGe nanocrystals
  on silicon
type: journal_article
volume: 5
year: '2010'
...
