[{"_id":"2439","intvolume":"        46","day":"01","issue":"5","publication_status":"published","quality_controlled":0,"publication":"Computational Geometry: Theory and Applications","author":[{"last_name":"Chen","first_name":"Dan","full_name":"Chen, Dan"},{"full_name":"Morin, Pat","first_name":"Pat","last_name":"Morin"},{"orcid":"0000-0002-1494-0568","last_name":"Wagner","first_name":"Uli","full_name":"Uli Wagner","id":"36690CA2-F248-11E8-B48F-1D18A9856A87"}],"date_published":"2012-07-01T00:00:00Z","volume":46,"month":"07","status":"public","publisher":"Elsevier","doi":"10.1016/j.comgeo.2012.03.001","citation":{"ista":"Chen D, Morin P, Wagner U. 2012. Absolute approximation of Tukey depth: Theory and experiments. Computational Geometry: Theory and Applications. 46(5), 566–573.","short":"D. Chen, P. Morin, U. Wagner, Computational Geometry: Theory and Applications 46 (2012) 566–573.","ama":"Chen D, Morin P, Wagner U. Absolute approximation of Tukey depth: Theory and experiments. <i>Computational Geometry: Theory and Applications</i>. 2012;46(5):566-573. doi:<a href=\"https://doi.org/10.1016/j.comgeo.2012.03.001\">10.1016/j.comgeo.2012.03.001</a>","chicago":"Chen, Dan, Pat Morin, and Uli Wagner. “Absolute Approximation of Tukey Depth: Theory and Experiments.” <i>Computational Geometry: Theory and Applications</i>. Elsevier, 2012. <a href=\"https://doi.org/10.1016/j.comgeo.2012.03.001\">https://doi.org/10.1016/j.comgeo.2012.03.001</a>.","apa":"Chen, D., Morin, P., &#38; Wagner, U. (2012). Absolute approximation of Tukey depth: Theory and experiments. <i>Computational Geometry: Theory and Applications</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.comgeo.2012.03.001\">https://doi.org/10.1016/j.comgeo.2012.03.001</a>","mla":"Chen, Dan, et al. “Absolute Approximation of Tukey Depth: Theory and Experiments.” <i>Computational Geometry: Theory and Applications</i>, vol. 46, no. 5, Elsevier, 2012, pp. 566–73, doi:<a href=\"https://doi.org/10.1016/j.comgeo.2012.03.001\">10.1016/j.comgeo.2012.03.001</a>.","ieee":"D. Chen, P. Morin, and U. Wagner, “Absolute approximation of Tukey depth: Theory and experiments,” <i>Computational Geometry: Theory and Applications</i>, vol. 46, no. 5. Elsevier, pp. 566–573, 2012."},"publist_id":"4467","date_updated":"2021-01-12T06:57:29Z","abstract":[{"lang":"eng","text":"A Monte Carlo approximation algorithm for the Tukey depth problem in high dimensions is introduced. The algorithm is a generalization of an algorithm presented by Rousseeuw and Struyf (1998) . The performance of this algorithm is studied both analytically and experimentally."}],"date_created":"2018-12-11T11:57:40Z","year":"2012","type":"journal_article","title":"Absolute approximation of Tukey depth: Theory and experiments","page":"566 - 573","extern":1},{"type":"journal_article","title":"Incomplete kloosterman sums and multiplicative inverses in short intervals","year":"2012","date_created":"2018-12-11T11:45:24Z","abstract":[{"text":"We investigate the solubility of the congruence xy ≡ 1 (mod p), where p is a prime and x, y are restricted to lie in suitable short intervals. Our work relies on a mean value theorem for incomplete Kloosterman sums.","lang":"eng"}],"date_updated":"2021-01-12T06:57:30Z","citation":{"short":"T.D. Browning, A. Haynes, International Journal of Number Theory 9 (2012) 481–486.","ista":"Browning TD, Haynes A. 2012. Incomplete kloosterman sums and multiplicative inverses in short intervals. International Journal of Number Theory. 9(2), 481–486.","ama":"Browning TD, Haynes A. Incomplete kloosterman sums and multiplicative inverses in short intervals. <i>International Journal of Number Theory</i>. 2012;9(2):481-486. doi:<a href=\"https://doi.org/ https://doi.org/10.1142/S1793042112501448\"> https://doi.org/10.1142/S1793042112501448</a>","ieee":"T. D. Browning and A. Haynes, “Incomplete kloosterman sums and multiplicative inverses in short intervals,” <i>International Journal of Number Theory</i>, vol. 9, no. 2. World Scientific Publishing, pp. 481–486, 2012.","mla":"Browning, Timothy D., and Alan Haynes. “Incomplete Kloosterman Sums and Multiplicative Inverses in Short Intervals.” <i>International Journal of Number Theory</i>, vol. 9, no. 2, World Scientific Publishing, 2012, pp. 481–86, doi:<a href=\"https://doi.org/ https://doi.org/10.1142/S1793042112501448\"> https://doi.org/10.1142/S1793042112501448</a>.","chicago":"Browning, Timothy D, and Alan Haynes. “Incomplete Kloosterman Sums and Multiplicative Inverses in Short Intervals.” <i>International Journal of Number Theory</i>. World Scientific Publishing, 2012. <a href=\"https://doi.org/ https://doi.org/10.1142/S1793042112501448\">https://doi.org/ https://doi.org/10.1142/S1793042112501448</a>.","apa":"Browning, T. D., &#38; Haynes, A. (2012). Incomplete kloosterman sums and multiplicative inverses in short intervals. <i>International Journal of Number Theory</i>. World Scientific Publishing. <a href=\"https://doi.org/ https://doi.org/10.1142/S1793042112501448\">https://doi.org/ https://doi.org/10.1142/S1793042112501448</a>"},"oa":1,"publist_id":"7660","extern":1,"acknowledgement":"EP/E053262/1\tEngineering and Physical Sciences Research Council\tEPSRC,\nEP/J00149X/1\tEngineering and Physical Sciences Research Council\tEPSRC\t","page":"481 - 486","doi":" https://doi.org/10.1142/S1793042112501448","publisher":"World Scientific Publishing","date_published":"2012-11-30T00:00:00Z","author":[{"orcid":"0000-0002-8314-0177","full_name":"Timothy Browning","id":"35827D50-F248-11E8-B48F-1D18A9856A87","first_name":"Timothy D","last_name":"Browning"},{"first_name":"Alan","full_name":"Haynes, Alan K","last_name":"Haynes"}],"main_file_link":[{"url":"https://arxiv.org/abs/1204.6374","open_access":"1"}],"status":"public","month":"11","volume":9,"day":"30","issue":"2","intvolume":"         9","_id":"244","publication":"International Journal of Number Theory","publication_status":"published","quality_controlled":0},{"extern":1,"conference":{"name":"SODA: Symposium on Discrete Algorithms"},"page":"1 - 10","title":"Computing all maps into a sphere","year":"2012","type":"conference","date_created":"2018-12-11T11:57:40Z","abstract":[{"lang":"eng","text":"We present an algorithm for computing [X, Y], i.e., all homotopy classes of continuous maps X → Y, where X, Y are topological spaces given as finite simplicial complexes, Y is (d - 1)-connected for some d ≥ 2 (for example, Y can be the d-dimensional sphere S d), and dim X ≤ 2d - 2. These conditions on X, Y guarantee that [X, Y] has a natural structure of a finitely generated Abelian group, and the algorithm finds generators and relations for it. We combine several tools and ideas from homotopy theory (such as Postnikov systems, simplicial sets, and obstruction theory) with algorithmic tools from effective algebraic topology (objects with effective homology). We hope that a further extension of the methods developed here will yield an algorithm for computing, in some cases of interest, the ℤ 2-index, which is a quantity playing a prominent role in Borsuk-Ulam style applications of topology in combinatorics and geometry, e.g., in topological lower bounds for the chromatic number of a graph. In a certain range of dimensions, deciding the embeddability of a simplicial complex into ℝ d also amounts to a ℤ 2-index computation. This is the main motivation of our work. We believe that investigating the computational complexity of questions in homotopy theory and similar areas presents a fascinating research area, and we hope that our work may help bridge the cultural gap between algebraic topology and theoretical computer science."}],"date_updated":"2021-01-12T06:57:30Z","publist_id":"4466","citation":{"ama":"Čadek M, Krcál M, Matoušek J, Sergeraert F, Vokřínek L, Wagner U. Computing all maps into a sphere. In: SIAM; 2012:1-10.","ista":"Čadek M, Krcál M, Matoušek J, Sergeraert F, Vokřínek L, Wagner U. 2012. Computing all maps into a sphere. SODA: Symposium on Discrete Algorithms, 1–10.","short":"M. Čadek, M. Krcál, J. Matoušek, F. Sergeraert, L. Vokřínek, U. Wagner, in:, SIAM, 2012, pp. 1–10.","apa":"Čadek, M., Krcál, M., Matoušek, J., Sergeraert, F., Vokřínek, L., &#38; Wagner, U. (2012). Computing all maps into a sphere (pp. 1–10). Presented at the SODA: Symposium on Discrete Algorithms, SIAM.","chicago":"Čadek, Martin, Marek Krcál, Jiří Matoušek, Francis Sergeraert, Lukáš Vokřínek, and Uli Wagner. “Computing All Maps into a Sphere,” 1–10. SIAM, 2012.","ieee":"M. Čadek, M. Krcál, J. Matoušek, F. Sergeraert, L. Vokřínek, and U. Wagner, “Computing all maps into a sphere,” presented at the SODA: Symposium on Discrete Algorithms, 2012, pp. 1–10.","mla":"Čadek, Martin, et al. <i>Computing All Maps into a Sphere</i>. SIAM, 2012, pp. 1–10."},"publisher":"SIAM","main_file_link":[{"url":"http://arxiv.org/abs/1105.6257","open_access":"0"}],"status":"public","month":"01","date_published":"2012-01-01T00:00:00Z","author":[{"first_name":"Martin","full_name":"Čadek, Martin","last_name":"Čadek"},{"first_name":"Marek","full_name":"Marek Krcál","id":"33E21118-F248-11E8-B48F-1D18A9856A87","last_name":"Krcál"},{"first_name":"Jiří","full_name":"Matoušek, Jiří","last_name":"Matoušek"},{"last_name":"Sergeraert","full_name":"Sergeraert, Francis","first_name":"Francis"},{"full_name":"Vokřínek, Lukáš","first_name":"Lukáš","last_name":"Vokřínek"},{"last_name":"Wagner","first_name":"Uli","id":"36690CA2-F248-11E8-B48F-1D18A9856A87","full_name":"Uli Wagner","orcid":"0000-0002-1494-0568"}],"quality_controlled":0,"publication_status":"published","day":"01","_id":"2440"},{"page":"151 - 160","extern":1,"conference":{"name":"SGC: Symposuim on Computational Geometry"},"date_updated":"2021-01-12T06:57:30Z","citation":{"ista":"Gundert A, Wagner U. 2012. On Laplacians of random complexes. SGC: Symposuim on Computational Geometry, 151–160.","short":"A. Gundert, U. Wagner, in:, ACM, 2012, pp. 151–160.","ama":"Gundert A, Wagner U. On Laplacians of random complexes. In: ACM; 2012:151-160. doi:<a href=\"https://doi.org/10.1145/2261250.2261272\">10.1145/2261250.2261272</a>","chicago":"Gundert, Anna, and Uli Wagner. “On Laplacians of Random Complexes,” 151–60. ACM, 2012. <a href=\"https://doi.org/10.1145/2261250.2261272\">https://doi.org/10.1145/2261250.2261272</a>.","apa":"Gundert, A., &#38; Wagner, U. (2012). On Laplacians of random complexes (pp. 151–160). Presented at the SGC: Symposuim on Computational Geometry, ACM. <a href=\"https://doi.org/10.1145/2261250.2261272\">https://doi.org/10.1145/2261250.2261272</a>","mla":"Gundert, Anna, and Uli Wagner. <i>On Laplacians of Random Complexes</i>. ACM, 2012, pp. 151–60, doi:<a href=\"https://doi.org/10.1145/2261250.2261272\">10.1145/2261250.2261272</a>.","ieee":"A. Gundert and U. Wagner, “On Laplacians of random complexes,” presented at the SGC: Symposuim on Computational Geometry, 2012, pp. 151–160."},"publist_id":"4464","type":"conference","year":"2012","title":"On Laplacians of random complexes","date_created":"2018-12-11T11:57:41Z","abstract":[{"lang":"eng","text":"Eigenvalues associated to graphs are a well-studied subject. In particular the spectra of the adjacency matrix and of the Laplacian of random graphs G(n, p) are known quite precisely. We consider generalizations of these matrices to simplicial complexes of higher dimensions and study their eigenvalues for the Linial-Meshulam model X k(n, p) of random k-dimensional simplicial complexes on n vertices. We show that for p = Ω(log n/n), the eigenvalues of both, the higher-dimensional adjacency matrix and the Laplacian, are a.a.s. sharply concentrated around two values. In a second part of the paper, we discuss a possible higherdimensional analogue of the Discrete Cheeger Inequality. This fundamental inequality expresses a close relationship between the eigenvalues of a graph and its combinatorial expansion properties; in particular, spectral expansion (a large eigenvalue gap) implies edge expansion. Recently, a higher-dimensional analogue of edge expansion for simplicial complexes was introduced by Gromov, and independently by Linial, Meshulam and Wallach and by Newman and Rabinovich. It is natural to ask whether there is a higher-dimensional version of Cheeger's inequality. We show that the most straightforward version of a higher-dimensional Cheeger inequality fails: for every k &gt; 1, there is an infinite family of k-dimensional complexes that are spectrally expanding (there is a large eigenvalue gap for the Laplacian) but not combinatorially expanding."}],"publisher":"ACM","doi":"10.1145/2261250.2261272","status":"public","month":"06","date_published":"2012-06-01T00:00:00Z","author":[{"first_name":"Anna","full_name":"Gundert, Anna","last_name":"Gundert"},{"orcid":"0000-0002-1494-0568","full_name":"Uli Wagner","id":"36690CA2-F248-11E8-B48F-1D18A9856A87","first_name":"Uli","last_name":"Wagner"}],"publication_status":"published","quality_controlled":0,"_id":"2441","day":"01"},{"publist_id":"4450","citation":{"chicago":"Feraru, Elena, Mugurel Feraru, Rin Asaoka, Tomasz Paciorek, Riet De Rycke, Hirokazu Tanaka, Akihiko Nakano, and Jiří Friml. “BEX5/RabA1b Regulates Trans-Golgi Network-to-Plasma Membrane Protein Trafficking in Arabidopsis.” <i>Plant Cell</i>. American Society of Plant Biologists, 2012. <a href=\"https://doi.org/10.1105/tpc.112.098152\">https://doi.org/10.1105/tpc.112.098152</a>.","apa":"Feraru, E., Feraru, M., Asaoka, R., Paciorek, T., De Rycke, R., Tanaka, H., … Friml, J. (2012). BEX5/RabA1b regulates trans-Golgi network-to-plasma membrane protein trafficking in Arabidopsis. <i>Plant Cell</i>. American Society of Plant Biologists. <a href=\"https://doi.org/10.1105/tpc.112.098152\">https://doi.org/10.1105/tpc.112.098152</a>","mla":"Feraru, Elena, et al. “BEX5/RabA1b Regulates Trans-Golgi Network-to-Plasma Membrane Protein Trafficking in Arabidopsis.” <i>Plant Cell</i>, vol. 24, no. 7, American Society of Plant Biologists, 2012, pp. 3074–86, doi:<a href=\"https://doi.org/10.1105/tpc.112.098152\">10.1105/tpc.112.098152</a>.","ieee":"E. Feraru <i>et al.</i>, “BEX5/RabA1b regulates trans-Golgi network-to-plasma membrane protein trafficking in Arabidopsis,” <i>Plant Cell</i>, vol. 24, no. 7. American Society of Plant Biologists, pp. 3074–3086, 2012.","ista":"Feraru E, Feraru M, Asaoka R, Paciorek T, De Rycke R, Tanaka H, Nakano A, Friml J. 2012. BEX5/RabA1b regulates trans-Golgi network-to-plasma membrane protein trafficking in Arabidopsis. Plant Cell. 24(7), 3074–3086.","short":"E. Feraru, M. Feraru, R. Asaoka, T. Paciorek, R. De Rycke, H. Tanaka, A. Nakano, J. Friml, Plant Cell 24 (2012) 3074–3086.","ama":"Feraru E, Feraru M, Asaoka R, et al. BEX5/RabA1b regulates trans-Golgi network-to-plasma membrane protein trafficking in Arabidopsis. <i>Plant Cell</i>. 2012;24(7):3074-3086. doi:<a href=\"https://doi.org/10.1105/tpc.112.098152\">10.1105/tpc.112.098152</a>"},"date_updated":"2021-01-12T06:57:35Z","date_created":"2018-12-11T11:57:45Z","abstract":[{"lang":"eng","text":"Constitutive endocytic recycling is a crucial mechanism allowing regulation of the activity of proteins at the plasma membrane and for rapid changes in their localization, as demonstrated in plants for PIN-FORMED (PIN) proteins, the auxin transporters. To identify novel molecular components of endocytic recycling, mainly exocytosis, we designed a PIN1-green fluorescent protein fluorescence imaging-based forward genetic screen for Arabidopsis thaliana mutants that showed increased intracellular accumulation of cargos in response to the trafficking inhibitor brefeldin A (BFA). We identified bex5 (for BFA-visualized exocytic trafficking defective), a novel dominant mutant carrying a missense mutation that disrupts a conserved sequence motif of the small GTPase, RAS GENES FROM RAT BRAINA1b. bex5 displays defects such as enhanced protein accumulation in abnormal BFA compartments, aberrant endosomes, and defective exocytosis and transcytosis. BEX5/RabA1b localizes to trans-Golgi network/early endosomes (TGN/EE) and acts on distinct trafficking processes like those regulated by GTP exchange factors on ADP-ribosylation factors GNOM-LIKE1 and HOPM INTERACTOR7/BFA-VISUALIZED ENDOCYTIC TRAFFICKING DEFECTIVE1, which regulate trafficking at the Golgi apparatus and TGN/EE, respectively. All together, this study identifies Arabidopsis BEX5/RabA1b as a novel regulator of protein trafficking from a TGN/EE compartment to the plasma membrane."}],"year":"2012","title":"BEX5/RabA1b regulates trans-Golgi network-to-plasma membrane protein trafficking in Arabidopsis","type":"journal_article","page":"3074 - 3086","extern":1,"publisher":"American Society of Plant Biologists","doi":"10.1105/tpc.112.098152","author":[{"last_name":"Feraru","first_name":"Elena","full_name":"Feraru, Elena"},{"last_name":"Feraru","full_name":"Feraru, Mugurel Ioan","first_name":"Mugurel"},{"last_name":"Asaoka","first_name":"Rin","full_name":"Asaoka, Rin"},{"last_name":"Paciorek","first_name":"Tomasz","full_name":"Paciorek, Tomasz"},{"last_name":"De Rycke","full_name":"De Rycke, Riet M","first_name":"Riet"},{"last_name":"Tanaka","full_name":"Tanaka, Hirokazu","first_name":"Hirokazu"},{"last_name":"Nakano","first_name":"Akihiko","full_name":"Nakano, Akihiko"},{"orcid":"0000-0002-8302-7596","first_name":"Jirí","full_name":"Jirí Friml","id":"4159519E-F248-11E8-B48F-1D18A9856A87","last_name":"Friml"}],"date_published":"2012-07-01T00:00:00Z","volume":24,"month":"07","status":"public","_id":"2453","intvolume":"        24","issue":"7","day":"01","quality_controlled":0,"publication_status":"published","publication":"Plant Cell"},{"user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","oa_version":"None","doi":"10.1242/dev.080861","publisher":"Company of Biologists","abstract":[{"lang":"eng","text":"The third EMBO Conference on Plant Molecular Biology, which focused on ‘Plant development and environmental interactions’,was held in May 2012 in Matera, Italy. Here, we review some of the topics and themes that emerged from the   various contributions; namely, steering technologies, transcriptional networks and hormonal regulation, small RNAs, cell and tissue polarity, environmental control and natural variation. We intend to provide the reader who might have missed this remarkable event with a glimpse of the recent progress made in this blossoming research field."}],"date_created":"2018-12-11T11:57:46Z","title":"Plant developmental biologists meet on stairways in Matera","year":"2012","type":"journal_article","publist_id":"4447","citation":{"ieee":"T. Beeckman and J. Friml, “Plant developmental biologists meet on stairways in Matera,” <i>Development</i>, vol. 139, no. 20. Company of Biologists, pp. 3677–3682, 2012.","mla":"Beeckman, Tom, and Jiří Friml. “Plant Developmental Biologists Meet on Stairways in Matera.” <i>Development</i>, vol. 139, no. 20, Company of Biologists, 2012, pp. 3677–82, doi:<a href=\"https://doi.org/10.1242/dev.080861\">10.1242/dev.080861</a>.","chicago":"Beeckman, Tom, and Jiří Friml. “Plant Developmental Biologists Meet on Stairways in Matera.” <i>Development</i>. Company of Biologists, 2012. <a href=\"https://doi.org/10.1242/dev.080861\">https://doi.org/10.1242/dev.080861</a>.","apa":"Beeckman, T., &#38; Friml, J. (2012). Plant developmental biologists meet on stairways in Matera. <i>Development</i>. Company of Biologists. <a href=\"https://doi.org/10.1242/dev.080861\">https://doi.org/10.1242/dev.080861</a>","short":"T. Beeckman, J. Friml, Development 139 (2012) 3677–3682.","ista":"Beeckman T, Friml J. 2012. Plant developmental biologists meet on stairways in Matera. Development. 139(20), 3677–3682.","ama":"Beeckman T, Friml J. Plant developmental biologists meet on stairways in Matera. <i>Development</i>. 2012;139(20):3677-3682. doi:<a href=\"https://doi.org/10.1242/dev.080861\">10.1242/dev.080861</a>"},"date_updated":"2021-01-12T06:57:35Z","extern":"1","page":"3677 - 3682","intvolume":"       139","day":"15","issue":"20","_id":"2456","publication":"Development","quality_controlled":"1","publication_status":"published","author":[{"full_name":"Beeckman, Tom","first_name":"Tom","last_name":"Beeckman"},{"last_name":"Friml","first_name":"Jirí","full_name":"Friml, Jirí","id":"4159519E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8302-7596"}],"date_published":"2012-10-15T00:00:00Z","month":"10","status":"public","language":[{"iso":"eng"}],"volume":139},{"page":"R635 - R637","extern":"1","date_updated":"2021-01-12T06:57:36Z","citation":{"mla":"Li, Hongjiang, et al. “Cell Polarity: Stretching Prevents Developmental Cramps.” <i>Current Biology</i>, vol. 22, no. 16, Cell Press, 2012, pp. R635–37, doi:<a href=\"https://doi.org/10.1016/j.cub.2012.06.053\">10.1016/j.cub.2012.06.053</a>.","ieee":"H. Li, J. Friml, and W. Grunewald, “Cell polarity: Stretching prevents developmental cramps,” <i>Current Biology</i>, vol. 22, no. 16. Cell Press, pp. R635–R637, 2012.","apa":"Li, H., Friml, J., &#38; Grunewald, W. (2012). Cell polarity: Stretching prevents developmental cramps. <i>Current Biology</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.cub.2012.06.053\">https://doi.org/10.1016/j.cub.2012.06.053</a>","chicago":"Li, Hongjiang, Jiří Friml, and Wim Grunewald. “Cell Polarity: Stretching Prevents Developmental Cramps.” <i>Current Biology</i>. Cell Press, 2012. <a href=\"https://doi.org/10.1016/j.cub.2012.06.053\">https://doi.org/10.1016/j.cub.2012.06.053</a>.","short":"H. Li, J. Friml, W. Grunewald, Current Biology 22 (2012) R635–R637.","ista":"Li H, Friml J, Grunewald W. 2012. Cell polarity: Stretching prevents developmental cramps. Current Biology. 22(16), R635–R637.","ama":"Li H, Friml J, Grunewald W. Cell polarity: Stretching prevents developmental cramps. <i>Current Biology</i>. 2012;22(16):R635-R637. doi:<a href=\"https://doi.org/10.1016/j.cub.2012.06.053\">10.1016/j.cub.2012.06.053</a>"},"publist_id":"4445","year":"2012","title":"Cell polarity: Stretching prevents developmental cramps","type":"journal_article","date_created":"2018-12-11T11:57:47Z","abstract":[{"text":"Initiation and successive development of organs induce mechanical stresses at the cellular level. Using the tomato shoot apex, a new study now proposes that mechanical strain regulates the plasma membrane abundance of the PIN1 auxin transporter, thereby reinforcing a positive feed-back loop between growth and auxin accumulation.","lang":"eng"}],"publisher":"Cell Press","doi":"10.1016/j.cub.2012.06.053","oa_version":"None","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","volume":22,"language":[{"iso":"eng"}],"status":"public","month":"08","date_published":"2012-08-21T00:00:00Z","author":[{"orcid":"0000-0001-5039-9660","first_name":"Hongjiang","id":"33CA54A6-F248-11E8-B48F-1D18A9856A87","full_name":"Li, Hongjiang","last_name":"Li"},{"orcid":"0000-0002-8302-7596","last_name":"Friml","first_name":"Jirí","full_name":"Friml, Jirí","id":"4159519E-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Grunewald, Wim","first_name":"Wim","last_name":"Grunewald"}],"publication_status":"published","quality_controlled":"1","publication":"Current Biology","_id":"2458","issue":"16","day":"21","intvolume":"        22"},{"publisher":"Frontiers Research Foundation","doi":"10.3389/fpls.2012.00097","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","file":[{"file_name":"2012_frontiers_Zwiewka.pdf","date_created":"2019-04-26T06:49:26Z","date_updated":"2020-07-14T12:45:41Z","file_id":"6346","file_size":1468230,"creator":"kschuh","checksum":"ab4e9487ccdb83a7a0a9ee6811521844","access_level":"open_access","content_type":"application/pdf","relation":"main_file"}],"extern":"1","license":"https://creativecommons.org/licenses/by-nc/4.0/","title":"Fluorescence imaging-based forward genetic screens to identify trafficking regulators in plants","year":"2012","publication_status":"published","quality_controlled":"1","_id":"2459","issue":"May","file_date_updated":"2020-07-14T12:45:41Z","status":"public","month":"05","author":[{"last_name":"Zwiewka","first_name":"Marta","full_name":"Zwiewka, Marta"},{"orcid":"0000-0002-8302-7596","last_name":"Friml","full_name":"Friml, Jirí","id":"4159519E-F248-11E8-B48F-1D18A9856A87","first_name":"Jirí"}],"oa_version":"Published Version","article_number":"97","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","image":"/images/cc_by_nc.png","short":"CC BY-NC (4.0)"},"date_updated":"2021-01-12T06:57:36Z","citation":{"ista":"Zwiewka M, Friml J. 2012. Fluorescence imaging-based forward genetic screens to identify trafficking regulators in plants. Frontiers in Plant Science. 3(May), 97.","short":"M. Zwiewka, J. Friml, Frontiers in Plant Science 3 (2012).","ama":"Zwiewka M, Friml J. Fluorescence imaging-based forward genetic screens to identify trafficking regulators in plants. <i>Frontiers in Plant Science</i>. 2012;3(May). doi:<a href=\"https://doi.org/10.3389/fpls.2012.00097\">10.3389/fpls.2012.00097</a>","mla":"Zwiewka, Marta, and Jiří Friml. “Fluorescence Imaging-Based Forward Genetic Screens to Identify Trafficking Regulators in Plants.” <i>Frontiers in Plant Science</i>, vol. 3, no. May, 97, Frontiers Research Foundation, 2012, doi:<a href=\"https://doi.org/10.3389/fpls.2012.00097\">10.3389/fpls.2012.00097</a>.","ieee":"M. Zwiewka and J. Friml, “Fluorescence imaging-based forward genetic screens to identify trafficking regulators in plants,” <i>Frontiers in Plant Science</i>, vol. 3, no. May. Frontiers Research Foundation, 2012.","chicago":"Zwiewka, Marta, and Jiří Friml. “Fluorescence Imaging-Based Forward Genetic Screens to Identify Trafficking Regulators in Plants.” <i>Frontiers in Plant Science</i>. Frontiers Research Foundation, 2012. <a href=\"https://doi.org/10.3389/fpls.2012.00097\">https://doi.org/10.3389/fpls.2012.00097</a>.","apa":"Zwiewka, M., &#38; Friml, J. (2012). Fluorescence imaging-based forward genetic screens to identify trafficking regulators in plants. <i>Frontiers in Plant Science</i>. Frontiers Research Foundation. <a href=\"https://doi.org/10.3389/fpls.2012.00097\">https://doi.org/10.3389/fpls.2012.00097</a>"},"oa":1,"publist_id":"4444","type":"journal_article","date_created":"2018-12-11T11:57:47Z","abstract":[{"lang":"eng","text":"Coordinated, subcellular trafficking of proteins is one of the fundamental properties of the multicellular eukaryotic organisms. Trafficking involves a large diversity of compartments, pathways, cargo molecules, and vesicle-sorting events. It is also crucial in regulating the localization and, thus, the activity of various proteins, but the process is still poorly genetically defined in plants. In the past, forward genetics screens had been used to determine the function of genes by searching for a specific morphological phenotype in the organism population in which mutations had been induced chemically or by irradiation. Unfortunately, these straightforward genetic screens turned out to be limited in identifying new regulators of intracellular protein transport, because mutations affecting essential trafficking pathways often lead to lethality. In addition, the use of these approaches has been restricted by functional redundancy among trafficking regulators. Screens for mutants that rely on the observation of changes in the cellular localization or dynamics of fluorescent subcellular markers enable, at least partially, to circumvent these issues. Hence, such image-based screens provide the possibility to identify either alleles with weak effects or components of the subcellular trafficking machinery that have no strong impact on the plant growth."}],"has_accepted_license":"1","publication":"Frontiers in Plant Science","day":"24","intvolume":"         3","language":[{"iso":"eng"}],"volume":3,"ddc":["580"],"date_published":"2012-05-24T00:00:00Z"},{"month":"03","status":"public","volume":73,"author":[{"last_name":"Abrahamsson","full_name":"Abrahamsson, Therese","first_name":"Therese"},{"last_name":"Cathala","first_name":"Laurence","full_name":"Cathala, Laurence"},{"last_name":"Matsui","full_name":"Matsui, Ko","first_name":"Ko"},{"orcid":"0000-0001-8761-9444","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Ryuichi Shigemoto","last_name":"Shigemoto"},{"last_name":"Digregorio","full_name":"DiGregorio, David A","first_name":"David"}],"date_published":"2012-03-22T00:00:00Z","publication":"Neuron","quality_controlled":0,"publication_status":"published","intvolume":"        73","day":"22","issue":"6","_id":"2474","extern":1,"page":"1159 - 1172","date_created":"2018-12-11T11:57:52Z","abstract":[{"text":"Interneurons are critical for neuronal circuit function, but how their dendritic morphologies and membrane properties influence information flow within neuronal circuits is largely unknown. We studied the spatiotemporal profile of synaptic integration and short-term plasticity in dendrites of mature cerebellar stellate cells by combining two-photon guided electrical stimulation, glutamate uncaging, electron microscopy, and modeling. Synaptic activation within thin (0.4 μm) dendrites produced somatic responses that became smaller and slower with increasing distance from the soma, sublinear subthreshold input-output relationships, and a somatodendritic gradient of short-term plasticity. Unlike most studies showing that neurons employ active dendritic mechanisms, we found that passive cable properties of thin dendrites determine the sublinear integration and plasticity gradient, which both result from large dendritic depolarizations that reduce synaptic driving force. These integrative properties allow stellate cells to act as spatiotemporal filters of synaptic input patterns, thereby biasing their output in favor of sparse presynaptic activity. Stellate cells are critical sources of inhibition in the cerebellum, but how their dendrites integrate excitatory synaptic inputs is unknown. Abrahamsson et al. show that thin dendrites and passive membrane properties of SCs promote sublinear synaptic summation and distance-dependent short-term plasticity. ","lang":"eng"}],"title":"Thin dendrites of cerebellar interneurons confer sublinear synaptic integration and a gradient of short-term plasticity","year":"2012","type":"journal_article","publist_id":"4427","citation":{"ieee":"T. Abrahamsson, L. Cathala, K. Matsui, R. Shigemoto, and D. Digregorio, “Thin dendrites of cerebellar interneurons confer sublinear synaptic integration and a gradient of short-term plasticity,” <i>Neuron</i>, vol. 73, no. 6. Elsevier, pp. 1159–1172, 2012.","mla":"Abrahamsson, Therese, et al. “Thin Dendrites of Cerebellar Interneurons Confer Sublinear Synaptic Integration and a Gradient of Short-Term Plasticity.” <i>Neuron</i>, vol. 73, no. 6, Elsevier, 2012, pp. 1159–72, doi:<a href=\"https://doi.org/10.1016/j.neuron.2012.01.027\">10.1016/j.neuron.2012.01.027</a>.","chicago":"Abrahamsson, Therese, Laurence Cathala, Ko Matsui, Ryuichi Shigemoto, and David Digregorio. “Thin Dendrites of Cerebellar Interneurons Confer Sublinear Synaptic Integration and a Gradient of Short-Term Plasticity.” <i>Neuron</i>. Elsevier, 2012. <a href=\"https://doi.org/10.1016/j.neuron.2012.01.027\">https://doi.org/10.1016/j.neuron.2012.01.027</a>.","apa":"Abrahamsson, T., Cathala, L., Matsui, K., Shigemoto, R., &#38; Digregorio, D. (2012). Thin dendrites of cerebellar interneurons confer sublinear synaptic integration and a gradient of short-term plasticity. <i>Neuron</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.neuron.2012.01.027\">https://doi.org/10.1016/j.neuron.2012.01.027</a>","ista":"Abrahamsson T, Cathala L, Matsui K, Shigemoto R, Digregorio D. 2012. Thin dendrites of cerebellar interneurons confer sublinear synaptic integration and a gradient of short-term plasticity. Neuron. 73(6), 1159–1172.","short":"T. Abrahamsson, L. Cathala, K. Matsui, R. Shigemoto, D. Digregorio, Neuron 73 (2012) 1159–1172.","ama":"Abrahamsson T, Cathala L, Matsui K, Shigemoto R, Digregorio D. Thin dendrites of cerebellar interneurons confer sublinear synaptic integration and a gradient of short-term plasticity. <i>Neuron</i>. 2012;73(6):1159-1172. doi:<a href=\"https://doi.org/10.1016/j.neuron.2012.01.027\">10.1016/j.neuron.2012.01.027</a>"},"date_updated":"2021-01-12T06:57:42Z","doi":"10.1016/j.neuron.2012.01.027","publisher":"Elsevier"},{"author":[{"first_name":"Yuhki","full_name":"Saito, Yuhki","last_name":"Saito"},{"last_name":"Inoue","first_name":"Tsuyoshi","full_name":"Inoue, Tsuyoshi"},{"last_name":"Zhu","first_name":"Gang","full_name":"Zhu, Gang"},{"last_name":"Kimura","first_name":"Naoki","full_name":"Kimura, Naoki"},{"last_name":"Okada","full_name":"Okada, Motohiro","first_name":"Motohiro"},{"first_name":"Masaki","full_name":"Nishimura, Masaki","last_name":"Nishimura"},{"full_name":"Murayama, Shigeo","first_name":"Shigeo","last_name":"Murayama"},{"full_name":"Kaneko, Sunao","first_name":"Sunao","last_name":"Kaneko"},{"first_name":"Ryuichi","full_name":"Ryuichi Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","orcid":"0000-0001-8761-9444"},{"last_name":"Imoto","full_name":"Imoto, Keiji","first_name":"Keiji"},{"full_name":"Suzuki, Toshiharu","first_name":"Toshiharu","last_name":"Suzuki"}],"date_published":"2012-10-03T00:00:00Z","month":"10","status":"public","volume":7,"intvolume":"         7","issue":"1","day":"03","_id":"2475","publication":"Molecular Neurodegeneration","publication_status":"published","quality_controlled":0,"abstract":[{"lang":"eng","text":"Background: One of the best-characterized causative factors of Alzheimer's disease (AD) is the generation of amyloid-β peptide (Aβ). AD subjects are at high risk of epileptic seizures accompanied by aberrant neuronal excitability, which in itself enhances Aβ generation. However, the molecular linkage between epileptic seizures and Aβ generation in AD remains unclear. Results: X11 and X11-like (X11L) gene knockout mice suffered from epileptic seizures, along with a malfunction of hyperpolarization-activated cyclic nucleotide gated (HCN) channels. Genetic ablation of HCN1 in mice and HCN1 channel blockage in cultured Neuro2a (N2a) cells enhanced Aβ generation. Interestingly, HCN1 levels dramatically decreased in the temporal lobe of cynomolgus monkeys (Macaca fascicularis) during aging and were significantly diminished in the temporal lobe of sporadic AD patients. Conclusion: Because HCN1 associates with amyloid-β precursor protein (APP) and X11/X11L in the brain, genetic deficiency of X11/X11L may induce aberrant HCN1 distribution along with epilepsy. Moreover, the reduction in HCN1 levels in aged primates may contribute to augmented Aβ generation. Taken together, HCN1 is proposed to play an important role in the molecular linkage between epileptic seizures and Aβ generation, and in the aggravation of sporadic AD."}],"date_created":"2018-12-11T11:57:53Z","year":"2012","type":"journal_article","title":"Hyperpolarization-activated cyclic nucleotide gated channels: A potential molecular link between epileptic seizures and Aβ generation in Alzheimer's disease","citation":{"chicago":"Saito, Yuhki, Tsuyoshi Inoue, Gang Zhu, Naoki Kimura, Motohiro Okada, Masaki Nishimura, Shigeo Murayama, et al. “Hyperpolarization-Activated Cyclic Nucleotide Gated Channels: A Potential Molecular Link between Epileptic Seizures and Aβ Generation in Alzheimer’s Disease.” <i>Molecular Neurodegeneration</i>. BioMed Central, 2012. <a href=\"https://doi.org/10.1186/1750-1326-7-50\">https://doi.org/10.1186/1750-1326-7-50</a>.","apa":"Saito, Y., Inoue, T., Zhu, G., Kimura, N., Okada, M., Nishimura, M., … Suzuki, T. (2012). Hyperpolarization-activated cyclic nucleotide gated channels: A potential molecular link between epileptic seizures and Aβ generation in Alzheimer’s disease. <i>Molecular Neurodegeneration</i>. BioMed Central. <a href=\"https://doi.org/10.1186/1750-1326-7-50\">https://doi.org/10.1186/1750-1326-7-50</a>","ieee":"Y. Saito <i>et al.</i>, “Hyperpolarization-activated cyclic nucleotide gated channels: A potential molecular link between epileptic seizures and Aβ generation in Alzheimer’s disease,” <i>Molecular Neurodegeneration</i>, vol. 7, no. 1. BioMed Central, 2012.","mla":"Saito, Yuhki, et al. “Hyperpolarization-Activated Cyclic Nucleotide Gated Channels: A Potential Molecular Link between Epileptic Seizures and Aβ Generation in Alzheimer’s Disease.” <i>Molecular Neurodegeneration</i>, vol. 7, no. 1, BioMed Central, 2012, doi:<a href=\"https://doi.org/10.1186/1750-1326-7-50\">10.1186/1750-1326-7-50</a>.","ama":"Saito Y, Inoue T, Zhu G, et al. Hyperpolarization-activated cyclic nucleotide gated channels: A potential molecular link between epileptic seizures and Aβ generation in Alzheimer’s disease. <i>Molecular Neurodegeneration</i>. 2012;7(1). doi:<a href=\"https://doi.org/10.1186/1750-1326-7-50\">10.1186/1750-1326-7-50</a>","ista":"Saito Y, Inoue T, Zhu G, Kimura N, Okada M, Nishimura M, Murayama S, Kaneko S, Shigemoto R, Imoto K, Suzuki T. 2012. Hyperpolarization-activated cyclic nucleotide gated channels: A potential molecular link between epileptic seizures and Aβ generation in Alzheimer’s disease. Molecular Neurodegeneration. 7(1).","short":"Y. Saito, T. Inoue, G. Zhu, N. Kimura, M. Okada, M. Nishimura, S. Murayama, S. Kaneko, R. Shigemoto, K. Imoto, T. Suzuki, Molecular Neurodegeneration 7 (2012)."},"publist_id":"4426","date_updated":"2021-01-12T06:57:42Z","extern":1,"doi":"10.1186/1750-1326-7-50","publisher":"BioMed Central"},{"extern":1,"page":"1517 - 1534","year":"2012","type":"journal_article","title":"Virus-mediated swapping of zolpidem-insensitive with zolpidem-sensitive GABA A receptors in cortical pyramidal cells","date_created":"2018-12-11T11:57:53Z","abstract":[{"lang":"eng","text":"Recently developed pharmacogenetic and optogenetic approaches, with their own advantages and disadvantages, have become indispensable tools in modern neuroscience. Here, we employed a previously described knock-in mouse line (GABA ARγ2 77Ilox) in which the γ2 subunit of the GABA A receptor (GABA AR) was mutated to become zolpidem insensitive (γ2 77I) and used viral vectors to swap γ2 77I with wild-type, zolpidem-sensitive γ2 subunits (γ2 77F). The verification of unaltered density and subcellular distribution of the virally introduced γ2 subunits requires their selective labelling. For this we generated six N- and six C-terminal-tagged γ2 subunits, with which cortical cultures of GABA ARγ2 -/- mice were transduced using lentiviruses. We found that the N-terminal AU1 tag resulted in excellent immunodetection and unimpaired synaptic localization. Unaltered kinetic properties of the AU1-tagged γ2 ( AU1γ2 77F) channels were demonstrated with whole-cell patch-clamp recordings of spontaneous IPSCs from cultured cells. Next, we carried out stereotaxic injections of lenti- and adeno-associated viruses containing Cre-recombinase and the AU1γ2 77F subunit (Cre-2A- AU1γ2 77F) into the neocortex of GABA ARγ2 77Ilox mice. Light microscopic immunofluorescence and electron microscopic freeze-fracture replica immunogold labelling demonstrated the efficient immunodetection of the AU1 tag and the normal enrichment of the AU1γ2 77F subunits in perisomatic GABAergic synapses. In line with this, miniature and action potential-evoked IPSCs whole-cell recorded from transduced cells had unaltered amplitudes, kinetics and restored zolpidem sensitivity. Our results obtained with a wide range of structural and functional verification methods reveal unaltered subcellular distributions and functional properties of γ2 77I and AU1γ2 77F GABA ARs in cortical pyramidal cells. This transgenic-viral pharmacogenetic approach has the advantage that it does not require any extrinsic protein that might endow some unforeseen alterations of the genetically modified cells. In addition, this virus-based approach opens up the possibility of modifying multiple cell types in distinct brain regions and performing alternative recombination-based intersectional genetic manipulations."}],"date_updated":"2021-01-12T06:57:43Z","citation":{"apa":"Sümegi, M., Fukazawa, Y., Matsui, K., Lörincz, A., Eyre, M., Nusser, Z., &#38; Shigemoto, R. (2012). Virus-mediated swapping of zolpidem-insensitive with zolpidem-sensitive GABA A receptors in cortical pyramidal cells. <i>Journal of Physiology</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1113/jphysiol.2012.227538\">https://doi.org/10.1113/jphysiol.2012.227538</a>","chicago":"Sümegi, Máté, Yugo Fukazawa, Ko Matsui, Andrea Lörincz, Mark Eyre, Zoltán Nusser, and Ryuichi Shigemoto. “Virus-Mediated Swapping of Zolpidem-Insensitive with Zolpidem-Sensitive GABA A Receptors in Cortical Pyramidal Cells.” <i>Journal of Physiology</i>. Wiley-Blackwell, 2012. <a href=\"https://doi.org/10.1113/jphysiol.2012.227538\">https://doi.org/10.1113/jphysiol.2012.227538</a>.","mla":"Sümegi, Máté, et al. “Virus-Mediated Swapping of Zolpidem-Insensitive with Zolpidem-Sensitive GABA A Receptors in Cortical Pyramidal Cells.” <i>Journal of Physiology</i>, vol. 590, no. 7, Wiley-Blackwell, 2012, pp. 1517–34, doi:<a href=\"https://doi.org/10.1113/jphysiol.2012.227538\">10.1113/jphysiol.2012.227538</a>.","ieee":"M. Sümegi <i>et al.</i>, “Virus-mediated swapping of zolpidem-insensitive with zolpidem-sensitive GABA A receptors in cortical pyramidal cells,” <i>Journal of Physiology</i>, vol. 590, no. 7. Wiley-Blackwell, pp. 1517–1534, 2012.","ama":"Sümegi M, Fukazawa Y, Matsui K, et al. Virus-mediated swapping of zolpidem-insensitive with zolpidem-sensitive GABA A receptors in cortical pyramidal cells. <i>Journal of Physiology</i>. 2012;590(7):1517-1534. doi:<a href=\"https://doi.org/10.1113/jphysiol.2012.227538\">10.1113/jphysiol.2012.227538</a>","short":"M. Sümegi, Y. Fukazawa, K. Matsui, A. Lörincz, M. Eyre, Z. Nusser, R. Shigemoto, Journal of Physiology 590 (2012) 1517–1534.","ista":"Sümegi M, Fukazawa Y, Matsui K, Lörincz A, Eyre M, Nusser Z, Shigemoto R. 2012. Virus-mediated swapping of zolpidem-insensitive with zolpidem-sensitive GABA A receptors in cortical pyramidal cells. Journal of Physiology. 590(7), 1517–1534."},"publist_id":"4425","doi":"10.1113/jphysiol.2012.227538","publisher":"Wiley-Blackwell","status":"public","month":"04","volume":590,"date_published":"2012-04-07T00:00:00Z","author":[{"full_name":"Sümegi, Máté","first_name":"Máté","last_name":"Sümegi"},{"last_name":"Fukazawa","first_name":"Yugo","full_name":"Fukazawa, Yugo"},{"first_name":"Ko","full_name":"Matsui, Ko","last_name":"Matsui"},{"last_name":"Lörincz","full_name":"Lörincz, Andrea","first_name":"Andrea"},{"last_name":"Eyre","first_name":"Mark","full_name":"Eyre, Mark D"},{"full_name":"Nusser, Zoltán","first_name":"Zoltán","last_name":"Nusser"},{"last_name":"Shigemoto","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Ryuichi Shigemoto","orcid":"0000-0001-8761-9444"}],"publication":"Journal of Physiology","publication_status":"published","quality_controlled":0,"day":"07","issue":"7","intvolume":"       590","_id":"2476"},{"month":"12","status":"public","volume":109,"author":[{"first_name":"Takuya","full_name":"Sasaki, Takuya","last_name":"Sasaki"},{"last_name":"Beppu","first_name":"Kaoru","full_name":"Beppu, Kaoru"},{"last_name":"Tanaka","full_name":"Tanaka, Kenji F","first_name":"Kenji"},{"full_name":"Fukazawa, Yugo","first_name":"Yugo","last_name":"Fukazawa"},{"first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Ryuichi Shigemoto","last_name":"Shigemoto","orcid":"0000-0001-8761-9444"},{"first_name":"Ko","full_name":"Matsui, Ko","last_name":"Matsui"}],"date_published":"2012-12-11T00:00:00Z","publication":"PNAS","quality_controlled":0,"publication_status":"published","intvolume":"       109","day":"11","issue":"50","_id":"2477","extern":1,"page":"20720 - 20725","date_created":"2018-12-11T11:57:54Z","abstract":[{"text":"Dynamic activity of glia has repeatedly been demonstrated, but if such activity is independent from neuronal activity, glia would not have any role in the information processing in the brain or in the generation of animal behavior. Evidence for neurons communicating with glia is solid, but the signaling pathway leading back from glial-to-neuronal activity was often difficult to study. Here, we introduced a transgenic mouse line in which channelrhodopsin-2, a light-gated cation channel, was expressed in astrocytes. Selective photostimulation of these astrocytes in vivo triggered neuronal activation. Using slice preparations, we show that glial photostimulation leads to release of glutamate, which was sufficient to activate AMPA receptors on Purkinje cells and to induce long-term depression of parallel fiber-to-Purkinje cell synapses through activation of metabotropic glutamate receptors. In contrast to neuronal synaptic vesicular release, glial activation likely causes preferential activation of extrasynaptic receptors that appose glial membrane. Finally, we show that neuronal activation by glial stimulation can lead to perturbation of cerebellar modulated motor behavior. These findings demonstrate that glia can modulate the tone of neuronal activity and behavior. This animal model is expected to be a potentially powerful approach to study the role of glia in brain function.","lang":"eng"}],"year":"2012","type":"journal_article","title":"Application of an optogenetic byway for perturbing neuronal activity via glial photostimulation","publist_id":"4424","citation":{"ieee":"T. Sasaki, K. Beppu, K. Tanaka, Y. Fukazawa, R. Shigemoto, and K. Matsui, “Application of an optogenetic byway for perturbing neuronal activity via glial photostimulation,” <i>PNAS</i>, vol. 109, no. 50. National Academy of Sciences, pp. 20720–20725, 2012.","mla":"Sasaki, Takuya, et al. “Application of an Optogenetic Byway for Perturbing Neuronal Activity via Glial Photostimulation.” <i>PNAS</i>, vol. 109, no. 50, National Academy of Sciences, 2012, pp. 20720–25, doi:<a href=\"https://doi.org/10.1073/pnas.1213458109\">10.1073/pnas.1213458109</a>.","chicago":"Sasaki, Takuya, Kaoru Beppu, Kenji Tanaka, Yugo Fukazawa, Ryuichi Shigemoto, and Ko Matsui. “Application of an Optogenetic Byway for Perturbing Neuronal Activity via Glial Photostimulation.” <i>PNAS</i>. National Academy of Sciences, 2012. <a href=\"https://doi.org/10.1073/pnas.1213458109\">https://doi.org/10.1073/pnas.1213458109</a>.","apa":"Sasaki, T., Beppu, K., Tanaka, K., Fukazawa, Y., Shigemoto, R., &#38; Matsui, K. (2012). Application of an optogenetic byway for perturbing neuronal activity via glial photostimulation. <i>PNAS</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.1213458109\">https://doi.org/10.1073/pnas.1213458109</a>","ama":"Sasaki T, Beppu K, Tanaka K, Fukazawa Y, Shigemoto R, Matsui K. Application of an optogenetic byway for perturbing neuronal activity via glial photostimulation. <i>PNAS</i>. 2012;109(50):20720-20725. doi:<a href=\"https://doi.org/10.1073/pnas.1213458109\">10.1073/pnas.1213458109</a>","ista":"Sasaki T, Beppu K, Tanaka K, Fukazawa Y, Shigemoto R, Matsui K. 2012. Application of an optogenetic byway for perturbing neuronal activity via glial photostimulation. PNAS. 109(50), 20720–20725.","short":"T. Sasaki, K. Beppu, K. Tanaka, Y. Fukazawa, R. Shigemoto, K. Matsui, PNAS 109 (2012) 20720–20725."},"date_updated":"2021-01-12T06:57:43Z","doi":"10.1073/pnas.1213458109","publisher":"National Academy of Sciences"},{"volume":32,"status":"public","month":"02","date_published":"2012-02-15T00:00:00Z","author":[{"first_name":"Timotheus","full_name":"Budisantoso, Timotheus","last_name":"Budisantoso"},{"last_name":"Matsui","full_name":"Matsui, Ko","first_name":"Ko"},{"last_name":"Kamasawa","first_name":"Naomi","full_name":"Kamasawa, Naomi"},{"full_name":"Fukazawa, Yugo","first_name":"Yugo","last_name":"Fukazawa"},{"orcid":"0000-0001-8761-9444","last_name":"Shigemoto","full_name":"Ryuichi Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi"}],"quality_controlled":0,"publication_status":"published","publication":"Journal of Neuroscience","_id":"2514","day":"15","issue":"7","intvolume":"        32","page":"2357 - 2376","extern":1,"date_updated":"2021-01-12T06:57:57Z","citation":{"ista":"Budisantoso T, Matsui K, Kamasawa N, Fukazawa Y, Shigemoto R. 2012. Mechanisms underlying signal filtering at a multisynapse contact. Journal of Neuroscience. 32(7), 2357–2376.","short":"T. Budisantoso, K. Matsui, N. Kamasawa, Y. Fukazawa, R. Shigemoto, Journal of Neuroscience 32 (2012) 2357–2376.","ama":"Budisantoso T, Matsui K, Kamasawa N, Fukazawa Y, Shigemoto R. Mechanisms underlying signal filtering at a multisynapse contact. <i>Journal of Neuroscience</i>. 2012;32(7):2357-2376. doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.5243-11.2012\">10.1523/JNEUROSCI.5243-11.2012</a>","apa":"Budisantoso, T., Matsui, K., Kamasawa, N., Fukazawa, Y., &#38; Shigemoto, R. (2012). Mechanisms underlying signal filtering at a multisynapse contact. <i>Journal of Neuroscience</i>. Society for Neuroscience. <a href=\"https://doi.org/10.1523/JNEUROSCI.5243-11.2012\">https://doi.org/10.1523/JNEUROSCI.5243-11.2012</a>","chicago":"Budisantoso, Timotheus, Ko Matsui, Naomi Kamasawa, Yugo Fukazawa, and Ryuichi Shigemoto. “Mechanisms Underlying Signal Filtering at a Multisynapse Contact.” <i>Journal of Neuroscience</i>. Society for Neuroscience, 2012. <a href=\"https://doi.org/10.1523/JNEUROSCI.5243-11.2012\">https://doi.org/10.1523/JNEUROSCI.5243-11.2012</a>.","ieee":"T. Budisantoso, K. Matsui, N. Kamasawa, Y. Fukazawa, and R. Shigemoto, “Mechanisms underlying signal filtering at a multisynapse contact,” <i>Journal of Neuroscience</i>, vol. 32, no. 7. Society for Neuroscience, pp. 2357–2376, 2012.","mla":"Budisantoso, Timotheus, et al. “Mechanisms Underlying Signal Filtering at a Multisynapse Contact.” <i>Journal of Neuroscience</i>, vol. 32, no. 7, Society for Neuroscience, 2012, pp. 2357–76, doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.5243-11.2012\">10.1523/JNEUROSCI.5243-11.2012</a>."},"publist_id":"4387","year":"2012","title":"Mechanisms underlying signal filtering at a multisynapse contact","type":"journal_article","date_created":"2018-12-11T11:58:07Z","abstract":[{"lang":"eng","text":"Visual information must be relayed through the lateral geniculate nucleus before it reaches the visual cortex. However, not all spikes created in the retina lead to postsynaptic spikes and properties of the retinogeniculate synapse contribute to this filtering. To understand the mechanisms underlying this filtering process, we conducted electrophysiology to assess the properties of signal transmission in the Long-Evans rat. We also performed SDS-digested freeze-fracture replica labeling to quantify the receptor and transporter distribution, as well as EM reconstruction to describe the 3D structure. To analyze the impact of transmitter diffusion on the activity of the receptors, simulations were integrated. We identified that a large contributor to the filtering is the marked paired-pulse depression at this synapse, which was intensified by the morphological characteristics of the contacts. The broad presynaptic and postsynaptic contact area restricts transmitter diffusion two dimensionally. Additionally, the presence of multiple closely arranged release sites invites intersynaptic spillover, which causes desensitization of AMPA receptors. The presence of AMPA receptors that slowly recover from desensitization along with the high presynaptic release probability and multivesicular release at each synapse also contribute to the depression. These features contrast with many other synapses where spatiotemporal spread of transmitter is limited by rapid transmitter clearance allowing synapses to operate more independently. We propose that the micrometer-order structure can ultimately affect the visual information processing."}],"publisher":"Society for Neuroscience","doi":"10.1523/JNEUROSCI.5243-11.2012"},{"volume":22,"status":"public","month":"06","date_published":"2012-06-01T00:00:00Z","author":[{"last_name":"Ballesteros Merino","full_name":"Ballesteros-Merino, Carmen","first_name":"Carmen"},{"last_name":"Lin","full_name":"Lin, Michael","first_name":"Michael"},{"last_name":"Wu","first_name":"Wendy","full_name":"Wu, Wendy W"},{"first_name":"Clotilde","full_name":"Ferrándiz-Huertas, Clotilde","last_name":"Ferrándiz Huertas"},{"full_name":"Cabañero, María José","first_name":"María","last_name":"Cabañero"},{"full_name":"Watanabe, Masahiko","first_name":"Masahiko","last_name":"Watanabe"},{"last_name":"Fukazawa","full_name":"Fukazawa, Yugo","first_name":"Yugo"},{"full_name":"Ryuichi Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","last_name":"Shigemoto","orcid":"0000-0001-8761-9444"},{"last_name":"Maylie","full_name":"Maylie, James G","first_name":"James"},{"full_name":"Adelman, John P","first_name":"John","last_name":"Adelman"},{"first_name":"Rafael","full_name":"Luján, Rafael","last_name":"Luján"}],"quality_controlled":0,"publication_status":"published","publication":"Hippocampus","_id":"2515","day":"01","issue":"6","intvolume":"        22","page":"1467 - 1480","extern":1,"date_updated":"2021-01-12T06:57:57Z","publist_id":"4386","citation":{"ista":"Ballesteros Merino C, Lin M, Wu W, Ferrándiz Huertas C, Cabañero M, Watanabe M, Fukazawa Y, Shigemoto R, Maylie J, Adelman J, Luján R. 2012.  Developmental profile of SK2 channel expression and function in CA1 neurons. Hippocampus. 22(6), 1467–1480.","short":"C. Ballesteros Merino, M. Lin, W. Wu, C. Ferrándiz Huertas, M. Cabañero, M. Watanabe, Y. Fukazawa, R. Shigemoto, J. Maylie, J. Adelman, R. Luján, Hippocampus 22 (2012) 1467–1480.","ama":"Ballesteros Merino C, Lin M, Wu W, et al.  Developmental profile of SK2 channel expression and function in CA1 neurons. <i>Hippocampus</i>. 2012;22(6):1467-1480. doi:<a href=\"https://doi.org/10.1002/hipo.20986\">10.1002/hipo.20986</a>","apa":"Ballesteros Merino, C., Lin, M., Wu, W., Ferrándiz Huertas, C., Cabañero, M., Watanabe, M., … Luján, R. (2012).  Developmental profile of SK2 channel expression and function in CA1 neurons. <i>Hippocampus</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1002/hipo.20986\">https://doi.org/10.1002/hipo.20986</a>","chicago":"Ballesteros Merino, Carmen, Michael Lin, Wendy Wu, Clotilde Ferrándiz Huertas, María Cabañero, Masahiko Watanabe, Yugo Fukazawa, et al. “ Developmental Profile of SK2 Channel Expression and Function in CA1 Neurons.” <i>Hippocampus</i>. Wiley-Blackwell, 2012. <a href=\"https://doi.org/10.1002/hipo.20986\">https://doi.org/10.1002/hipo.20986</a>.","mla":"Ballesteros Merino, Carmen, et al. “ Developmental Profile of SK2 Channel Expression and Function in CA1 Neurons.” <i>Hippocampus</i>, vol. 22, no. 6, Wiley-Blackwell, 2012, pp. 1467–80, doi:<a href=\"https://doi.org/10.1002/hipo.20986\">10.1002/hipo.20986</a>.","ieee":"C. Ballesteros Merino <i>et al.</i>, “ Developmental profile of SK2 channel expression and function in CA1 neurons,” <i>Hippocampus</i>, vol. 22, no. 6. Wiley-Blackwell, pp. 1467–1480, 2012."},"title":" Developmental profile of SK2 channel expression and function in CA1 neurons","type":"journal_article","year":"2012","date_created":"2018-12-11T11:58:07Z","abstract":[{"lang":"eng","text":"We investigated the temporal and spatial expression of SK2 in the developing mouse hippocampus using molecular and biochemical techniques, quantitative immunogold electron microscopy, and electrophysiology. The mRNA encoding SK2 was expressed in the developing and adult hippocampus. Western blotting and immunohistochemistry showed that SK2 protein increased with age. This was accompanied by a shift in subcellular localization. Early in development (P5), SK2 was predominantly localized to the endoplasmic reticulum in the pyramidal cell layer. But by P30 SK2 was almost exclusively expressed in the dendrites and spines. The level of SK2 at the postsynaptic density (PSD) also increased during development. In the adult, SK2 expression on the spine plasma membrane showed a proximal-to-distal gradient. Consistent with this redistribution and gradient of SK2, the selective SK channel blocker apamin increased evoked excitatory postsynaptic potentials (EPSPs) only in CA1 pyramidal neurons from mice older than P15. However, the effect of apamin on EPSPs was not different between synapses in proximal or distal stratum radiatum or stratum lacunosum-moleculare in adult. These results show a developmental increase and gradient in SK2-containing channel surface expression that underlie their influence on neurotransmission, and that may contribute to increased memory acquisition during early development."}],"publisher":"Wiley-Blackwell","doi":"10.1002/hipo.20986"},{"publisher":"American Association for the Advancement of Science","doi":"10.1126/science.1225182","publist_id":"5404","citation":{"ama":"Kicheva A, Cohen M, Briscoe J. Developmental pattern formation: Insights from physics and biology. <i>Science</i>. 2012;338(6104):210-212. doi:<a href=\"https://doi.org/10.1126/science.1225182\">10.1126/science.1225182</a>","ista":"Kicheva A, Cohen M, Briscoe J. 2012. Developmental pattern formation: Insights from physics and biology. Science. 338(6104), 210–212.","short":"A. Kicheva, M. Cohen, J. Briscoe, Science 338 (2012) 210–212.","chicago":"Kicheva, Anna, Michael Cohen, and James Briscoe. “Developmental Pattern Formation: Insights from Physics and Biology.” <i>Science</i>. American Association for the Advancement of Science, 2012. <a href=\"https://doi.org/10.1126/science.1225182\">https://doi.org/10.1126/science.1225182</a>.","apa":"Kicheva, A., Cohen, M., &#38; Briscoe, J. (2012). Developmental pattern formation: Insights from physics and biology. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1225182\">https://doi.org/10.1126/science.1225182</a>","ieee":"A. Kicheva, M. Cohen, and J. Briscoe, “Developmental pattern formation: Insights from physics and biology,” <i>Science</i>, vol. 338, no. 6104. American Association for the Advancement of Science, pp. 210–212, 2012.","mla":"Kicheva, Anna, et al. “Developmental Pattern Formation: Insights from Physics and Biology.” <i>Science</i>, vol. 338, no. 6104, American Association for the Advancement of Science, 2012, pp. 210–12, doi:<a href=\"https://doi.org/10.1126/science.1225182\">10.1126/science.1225182</a>."},"date_updated":"2021-01-12T06:52:47Z","abstract":[{"lang":"eng","text":"The spatial organization of cell fates during development involves the interpretation of morphogen gradients by cellular signaling cascades and transcriptional networks. Recent studies use biophysical models, genetics, and quantitative imaging to unravel how tissue-level morphogen behavior arises from subcellular events. Moreover, data from several systems show that morphogen gradients, downstream signaling, and the activity of cell-intrinsic transcriptional networks change dynamically during pattern formation. Studies from Drosophila and now also vertebrates suggest that transcriptional network dynamics are central to the generation of gene expression patterns. Together, this leads to the view that pattern formation is an emergent behavior that results from the coordination of events occurring across molecular, cellular, and tissue scales. The development of novel approaches to study this complex process remains a challenge."}],"date_created":"2018-12-11T11:53:40Z","type":"journal_article","year":"2012","title":"Developmental pattern formation: Insights from physics and biology","page":"210 - 212","acknowledgement":"Funding provided by the Medical Research Council (UK). ","extern":1,"_id":"1725","intvolume":"       338","issue":"6104","day":"12","quality_controlled":0,"publication_status":"published","publication":"Science","author":[{"orcid":"0000-0003-4509-4998","first_name":"Anna","full_name":"Anna Kicheva","id":"3959A2A0-F248-11E8-B48F-1D18A9856A87","last_name":"Kicheva"},{"full_name":"Cohen, Michael H","first_name":"Michael","last_name":"Cohen"},{"first_name":"James","full_name":"Briscoe, James","last_name":"Briscoe"}],"date_published":"2012-10-12T00:00:00Z","volume":338,"month":"10","status":"public"},{"author":[{"first_name":"Massimo","full_name":"Mongillo, Massimo","last_name":"Mongillo"},{"full_name":"Spathis, Panayotis N","first_name":"Panayotis","last_name":"Spathis"},{"full_name":"Georgios Katsaros","id":"38DB5788-F248-11E8-B48F-1D18A9856A87","first_name":"Georgios","last_name":"Katsaros"},{"first_name":"Pascal","full_name":"Gentile, Pascal","last_name":"Gentile"},{"full_name":"De Franceschi, Silvano","first_name":"Silvano","last_name":"De Franceschi"}],"date_published":"2012-06-13T00:00:00Z","volume":12,"month":"06","status":"public","main_file_link":[{"url":"http://arxiv.org/abs/1208.1465","open_access":"1"}],"_id":"1756","intvolume":"        12","day":"13","issue":"6","publication_status":"published","quality_controlled":0,"publication":"Nano Letters","oa":1,"publist_id":"5368","citation":{"ama":"Mongillo M, Spathis P, Katsaros G, Gentile P, De Franceschi S. Multifunctional devices and logic gates with undoped silicon nanowires. <i>Nano Letters</i>. 2012;12(6):3074-3079. doi:<a href=\"https://doi.org/10.1021/nl300930m\">10.1021/nl300930m</a>","short":"M. Mongillo, P. Spathis, G. Katsaros, P. Gentile, S. De Franceschi, Nano Letters 12 (2012) 3074–3079.","ista":"Mongillo M, Spathis P, Katsaros G, Gentile P, De Franceschi S. 2012. Multifunctional devices and logic gates with undoped silicon nanowires. Nano Letters. 12(6), 3074–3079.","apa":"Mongillo, M., Spathis, P., Katsaros, G., Gentile, P., &#38; De Franceschi, S. (2012). Multifunctional devices and logic gates with undoped silicon nanowires. <i>Nano Letters</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/nl300930m\">https://doi.org/10.1021/nl300930m</a>","chicago":"Mongillo, Massimo, Panayotis Spathis, Georgios Katsaros, Pascal Gentile, and Silvano De Franceschi. “Multifunctional Devices and Logic Gates with Undoped Silicon Nanowires.” <i>Nano Letters</i>. American Chemical Society, 2012. <a href=\"https://doi.org/10.1021/nl300930m\">https://doi.org/10.1021/nl300930m</a>.","ieee":"M. Mongillo, P. Spathis, G. Katsaros, P. Gentile, and S. De Franceschi, “Multifunctional devices and logic gates with undoped silicon nanowires,” <i>Nano Letters</i>, vol. 12, no. 6. American Chemical Society, pp. 3074–3079, 2012.","mla":"Mongillo, Massimo, et al. “Multifunctional Devices and Logic Gates with Undoped Silicon Nanowires.” <i>Nano Letters</i>, vol. 12, no. 6, American Chemical Society, 2012, pp. 3074–79, doi:<a href=\"https://doi.org/10.1021/nl300930m\">10.1021/nl300930m</a>."},"date_updated":"2021-01-12T06:53:00Z","date_created":"2018-12-11T11:53:50Z","abstract":[{"lang":"eng","text":"We report on the electronic transport properties of multiple-gate devices fabricated from undoped silicon nanowires. Understanding and control of the relevant transport mechanisms was achieved by means of local electrostatic gating and temperature-dependent measurements. The roles of the source/drain contacts and of the silicon channel could be independently evaluated and tuned. Wrap gates surrounding the silicide-silicon contact interfaces were proved to be effective in inducing a full suppression of the contact Schottky barriers, thereby enabling carrier injection down to liquid helium temperature. By independently tuning the effective Schottky barrier heights, a variety of reconfigurable device functionalities could be obtained. In particular, the same nanowire device could be configured to work as a Schottky barrier transistor, a Schottky diode, or a p-n diode with tunable polarities. This versatility was eventually exploited to realize a NAND logic gate with gain well above one."}],"title":"Multifunctional devices and logic gates with undoped silicon nanowires","year":"2012","type":"journal_article","page":"3074 - 3079","acknowledgement":"This work was supported by the Agence Nationale de la Recherche (ANR) through the ACCESS and COHESION projects and by the European Commission through the Chemtronics program MEST-CT-2005-020513","extern":1,"publisher":"American Chemical Society","doi":"10.1021/nl300930m"},{"date_updated":"2021-01-12T06:53:00Z","publist_id":"5367","oa":1,"citation":{"ama":"Zhang J, Katsaros G, Montalenti F, et al. Monolithic growth of ultrathin Ge nanowires on Si(001) . <i>Physical Review Letters</i>. 2012;109(8). doi:<a href=\"https://doi.org/10.1103/PhysRevLett.109.085502\">10.1103/PhysRevLett.109.085502</a>","short":"J. Zhang, G. Katsaros, F. Montalenti, D. Scopece, R. Rezaev, C. Mickel, B. Rellinghaus, L. Miglio, S. De Franceschi, A. Rastelli, O. Schmidt, Physical Review Letters 109 (2012).","ista":"Zhang J, Katsaros G, Montalenti F, Scopece D, Rezaev R, Mickel C, Rellinghaus B, Miglio L, De Franceschi S, Rastelli A, Schmidt O. 2012. Monolithic growth of ultrathin Ge nanowires on Si(001) . Physical Review Letters. 109(8).","apa":"Zhang, J., Katsaros, G., Montalenti, F., Scopece, D., Rezaev, R., Mickel, C., … Schmidt, O. (2012). Monolithic growth of ultrathin Ge nanowires on Si(001) . <i>Physical Review Letters</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevLett.109.085502\">https://doi.org/10.1103/PhysRevLett.109.085502</a>","chicago":"Zhang, Jianjun, Georgios Katsaros, Francesco Montalenti, Daniele Scopece, Roman Rezaev, Christine Mickel, Bernd Rellinghaus, et al. “Monolithic Growth of Ultrathin Ge Nanowires on Si(001) .” <i>Physical Review Letters</i>. American Physical Society, 2012. <a href=\"https://doi.org/10.1103/PhysRevLett.109.085502\">https://doi.org/10.1103/PhysRevLett.109.085502</a>.","ieee":"J. Zhang <i>et al.</i>, “Monolithic growth of ultrathin Ge nanowires on Si(001) ,” <i>Physical Review Letters</i>, vol. 109, no. 8. American Physical Society, 2012.","mla":"Zhang, Jianjun, et al. “Monolithic Growth of Ultrathin Ge Nanowires on Si(001) .” <i>Physical Review Letters</i>, vol. 109, no. 8, American Physical Society, 2012, doi:<a href=\"https://doi.org/10.1103/PhysRevLett.109.085502\">10.1103/PhysRevLett.109.085502</a>."},"title":"Monolithic growth of ultrathin Ge nanowires on Si(001) ","year":"2012","type":"journal_article","abstract":[{"text":"Self-assembled Ge wires with a height of only 3 unit cells and a length of up to 2 micrometers were grown on Si(001) by means of a catalyst-free method based on molecular beam epitaxy. The wires grow horizontally along either the [100] or the [010] direction. On atomically flat surfaces, they exhibit a highly uniform, triangular cross section. A simple thermodynamic model accounts for the existence of a preferential base width for longitudinal expansion, in quantitative agreement with the experimental findings. Despite the absence of intentional doping, the first transistor-type devices made from single wires show low-resistive electrical contacts and single-hole transport at sub-Kelvin temperatures. In view of their exceptionally small and self-defined cross section, these Ge wires hold promise for the realization of hole systems with exotic properties and provide a new development route for silicon-based nanoelectronics.","lang":"eng"}],"date_created":"2018-12-11T11:53:51Z","extern":1,"acknowledgement":"We acknowledge the financial support by the DFG SPP1386, P. Chen and D. J. Thurmer for MBE assistance, R. Wacquez for providing the ultrathin SOI wafers, and G. Bauer, Y. Hu, X. Jehl, S. Kiravittaya, C. Klöffel, E. J. H. Lee, F. Liu, D. Loss, and S. Mahapatra for helpful discussions. G. K. acknowledges support from the European commission via a Marie Curie Carrer Integration Grant. S. D. F. acknowledges support from the European Research Council through the starting grant program","publisher":"American Physical Society","doi":"10.1103/PhysRevLett.109.085502","date_published":"2012-08-23T00:00:00Z","author":[{"last_name":"Zhang","first_name":"Jianjun","full_name":"Zhang, Jianjun"},{"full_name":"Georgios Katsaros","id":"38DB5788-F248-11E8-B48F-1D18A9856A87","first_name":"Georgios","last_name":"Katsaros"},{"last_name":"Montalenti","first_name":"Francesco","full_name":"Montalenti, Francesco"},{"last_name":"Scopece","first_name":"Daniele","full_name":"Scopece, Daniele"},{"last_name":"Rezaev","full_name":"Rezaev, Roman O","first_name":"Roman"},{"full_name":"Mickel, Christine H","first_name":"Christine","last_name":"Mickel"},{"last_name":"Rellinghaus","full_name":"Rellinghaus, Bernd","first_name":"Bernd"},{"first_name":"Leo","full_name":"Miglio, Leo P","last_name":"Miglio"},{"first_name":"Silvano","full_name":"De Franceschi, Silvano","last_name":"De Franceschi"},{"last_name":"Rastelli","first_name":"Armando","full_name":"Rastelli, Armando"},{"full_name":"Schmidt, Oliver G","first_name":"Oliver","last_name":"Schmidt"}],"volume":109,"status":"public","main_file_link":[{"url":"http://arxiv.org/abs/1208.0666","open_access":"1"}],"month":"08","_id":"1757","issue":"8","day":"23","intvolume":"       109","publication_status":"published","quality_controlled":0,"publication":"Physical Review Letters"},{"extern":1,"acknowledgement":"This work was supported by the EU Marie Curie program and by the Agence Nationale de la Recherche. R. A. acknowledges support from the Spanish Ministry of Science and Innovation through Grant No. FIS2009-08744","year":"2012","title":"Zero-bias anomaly in a nanowire quantum dot coupled to superconductors","type":"journal_article","abstract":[{"text":"We studied the low-energy states of spin-1/2 quantum dots defined in InAs/InP nanowires and coupled to aluminum superconducting leads. By varying the superconducting gap Δ with a magnetic field B we investigated the transition from strong coupling Δ≪T K to weak-coupling Δ≫T K, where T K is the Kondo temperature. Below the critical field, we observe a persisting zero-bias Kondo resonance that vanishes only for low B or higher temperatures, leaving the room to more robust subgap structures at bias voltages between Δ and 2Δ. For strong and approximately symmetric tunnel couplings, a Josephson supercurrent is observed in addition to the Kondo peak. We ascribe the coexistence of a Kondo resonance and a superconducting gap to a significant density of intragap quasiparticle states, and the finite-bias subgap structures to tunneling through Shiba states. Our results, supported by numerical calculations, own relevance also in relation to tunnel-spectroscopy experiments aiming at the observation of Majorana fermions in hybrid nanostructures.","lang":"eng"}],"date_created":"2018-12-11T11:53:51Z","date_updated":"2021-01-12T06:53:01Z","oa":1,"publist_id":"5366","citation":{"apa":"Lee, E., Jiang, X., Aguado, R., Katsaros, G., Lieber, C., &#38; De Franceschi, S. (2012). Zero-bias anomaly in a nanowire quantum dot coupled to superconductors. <i>Physical Review Letters</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevLett.109.186802\">https://doi.org/10.1103/PhysRevLett.109.186802</a>","chicago":"Lee, Eduardo, Xiaocheng Jiang, Ramón Aguado, Georgios Katsaros, Charles Lieber, and Silvano De Franceschi. “Zero-Bias Anomaly in a Nanowire Quantum Dot Coupled to Superconductors.” <i>Physical Review Letters</i>. American Physical Society, 2012. <a href=\"https://doi.org/10.1103/PhysRevLett.109.186802\">https://doi.org/10.1103/PhysRevLett.109.186802</a>.","ieee":"E. Lee, X. Jiang, R. Aguado, G. Katsaros, C. Lieber, and S. De Franceschi, “Zero-bias anomaly in a nanowire quantum dot coupled to superconductors,” <i>Physical Review Letters</i>, vol. 109, no. 18. American Physical Society, 2012.","mla":"Lee, Eduardo, et al. “Zero-Bias Anomaly in a Nanowire Quantum Dot Coupled to Superconductors.” <i>Physical Review Letters</i>, vol. 109, no. 18, American Physical Society, 2012, doi:<a href=\"https://doi.org/10.1103/PhysRevLett.109.186802\">10.1103/PhysRevLett.109.186802</a>.","ama":"Lee E, Jiang X, Aguado R, Katsaros G, Lieber C, De Franceschi S. Zero-bias anomaly in a nanowire quantum dot coupled to superconductors. <i>Physical Review Letters</i>. 2012;109(18). doi:<a href=\"https://doi.org/10.1103/PhysRevLett.109.186802\">10.1103/PhysRevLett.109.186802</a>","short":"E. Lee, X. Jiang, R. Aguado, G. Katsaros, C. Lieber, S. De Franceschi, Physical Review Letters 109 (2012).","ista":"Lee E, Jiang X, Aguado R, Katsaros G, Lieber C, De Franceschi S. 2012. Zero-bias anomaly in a nanowire quantum dot coupled to superconductors. Physical Review Letters. 109(18)."},"doi":"10.1103/PhysRevLett.109.186802","publisher":"American Physical Society","main_file_link":[{"open_access":"1","url":"http://arxiv.org/abs/1207.1259"}],"status":"public","month":"10","volume":109,"date_published":"2012-10-31T00:00:00Z","author":[{"last_name":"Lee","full_name":"Lee, Eduardo J","first_name":"Eduardo"},{"last_name":"Jiang","first_name":"Xiaocheng","full_name":"Jiang, Xiaocheng"},{"full_name":"Aguado, Ramón","first_name":"Ramón","last_name":"Aguado"},{"full_name":"Georgios Katsaros","id":"38DB5788-F248-11E8-B48F-1D18A9856A87","first_name":"Georgios","last_name":"Katsaros"},{"last_name":"Lieber","full_name":"Lieber, Charles M","first_name":"Charles"},{"last_name":"De Franceschi","first_name":"Silvano","full_name":"De Franceschi, Silvano"}],"publication":"Physical Review Letters","publication_status":"published","quality_controlled":0,"day":"31","issue":"18","intvolume":"       109","_id":"1758"},{"date_published":"2012-12-11T00:00:00Z","language":[{"iso":"eng"}],"volume":427,"intvolume":"       427","day":"11","publication":"Monthly Notices of the Royal Astronomical Society","alternative_title":["Overflow and migration: SMBH binaries"],"abstract":[{"text":"We study the interaction of a supermassive black hole (SMBH) binary and a standard radiatively efficient thin accretion disk. We examine steady-state configurations of the disk and migrating SMBH system, self-consistently accounting for tidal and viscous torques and heating, radiative diffusion limited cooling, gas and radiation pressure, and the decay of the binary's orbit. We obtain a \"phase diagram\" of the system as a function of binary parameters, showing regimes in which both the disk structure and migration have a different character. Although massive binaries can create a central gap in the disk at large radii, the tidal barrier of the secondary causes a significant pile-up of gas outside of its orbit, which can lead to the closing of the gap. We find that this spillover occurs at an orbital separation as large as ~200 M_7^{-1/2} gravitational radii, where M = 10^7 M_7 Msun is the total binary mass. If the secondary is less massive than ~10^6 Msun, then the gap is closed before gravitational waves (GWs) start dominating the orbital decay. In this regime, the disk is still strongly perturbed, but the piled-up gas continuously overflows as in a porous dam, and crosses inside the secondary's orbit. The corresponding migration rate, which we label Type 1.5, is slower than the usual limiting cases known as Type I and II migration. Compared to an unperturbed disk, the steady-state disk in the overflowing regime is up to several hundred times brighter in the optical bands. Surveys such as PanSTARRS or LSST may discover the periodic variability of this population of binaries. Our results imply that the circumbinary disks around SMBHs can extend to small radii during the last stages of their merger, when they are detectable by LISA, and may produce coincident electromagnetic (EM) emission similar to active galactic nuclei (AGN).","lang":"eng"}],"date_created":"2024-09-05T13:28:17Z","type":"journal_article","citation":{"chicago":"Kocsis, Bence, Zoltán Haiman, and Abraham Loeb. “Gas Pile-up, Gap Overflow and Type 1.5 Migration in Circumbinary Discs: Application to Supermassive Black Hole Binaries.” <i>Monthly Notices of the Royal Astronomical Society</i>. Oxford University Press, 2012. <a href=\"https://doi.org/10.1111/j.1365-2966.2012.22118.x\">https://doi.org/10.1111/j.1365-2966.2012.22118.x</a>.","apa":"Kocsis, B., Haiman, Z., &#38; Loeb, A. (2012). Gas pile-up, gap overflow and Type 1.5 migration in circumbinary discs: Application to supermassive black hole binaries. <i>Monthly Notices of the Royal Astronomical Society</i>. Oxford University Press. <a href=\"https://doi.org/10.1111/j.1365-2966.2012.22118.x\">https://doi.org/10.1111/j.1365-2966.2012.22118.x</a>","mla":"Kocsis, Bence, et al. “Gas Pile-up, Gap Overflow and Type 1.5 Migration in Circumbinary Discs: Application to Supermassive Black Hole Binaries.” <i>Monthly Notices of the Royal Astronomical Society</i>, vol. 427, no. 3, Oxford University Press, 2012, pp. 2680–700, doi:<a href=\"https://doi.org/10.1111/j.1365-2966.2012.22118.x\">10.1111/j.1365-2966.2012.22118.x</a>.","ieee":"B. Kocsis, Z. Haiman, and A. Loeb, “Gas pile-up, gap overflow and Type 1.5 migration in circumbinary discs: Application to supermassive black hole binaries,” <i>Monthly Notices of the Royal Astronomical Society</i>, vol. 427, no. 3. Oxford University Press, pp. 2680–2700, 2012.","ista":"Kocsis B, Haiman Z, Loeb A. 2012. Gas pile-up, gap overflow and Type 1.5 migration in circumbinary discs: Application to supermassive black hole binaries. Monthly Notices of the Royal Astronomical Society. 427(3), 2680–2700.","short":"B. Kocsis, Z. Haiman, A. Loeb, Monthly Notices of the Royal Astronomical Society 427 (2012) 2680–2700.","ama":"Kocsis B, Haiman Z, Loeb A. Gas pile-up, gap overflow and Type 1.5 migration in circumbinary discs: Application to supermassive black hole binaries. <i>Monthly Notices of the Royal Astronomical Society</i>. 2012;427(3):2680-2700. doi:<a href=\"https://doi.org/10.1111/j.1365-2966.2012.22118.x\">10.1111/j.1365-2966.2012.22118.x</a>"},"oa":1,"date_updated":"2024-09-24T07:40:02Z","article_processing_charge":"No","oa_version":"Published Version","scopus_import":"1","publication_identifier":{"issn":["0035-8711","1365-2966"]},"author":[{"full_name":"Kocsis, Bence","first_name":"Bence","last_name":"Kocsis"},{"last_name":"Haiman","full_name":"Haiman, Zoltán","id":"7c006e8c-cc0d-11ee-8322-cb904ef76f36","first_name":"Zoltán"},{"first_name":"Abraham","full_name":"Loeb, Abraham","last_name":"Loeb"}],"month":"12","status":"public","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1111/j.1365-2966.2012.22118.x"}],"article_type":"original","issue":"3","_id":"17613","quality_controlled":"1","publication_status":"published","year":"2012","title":"Gas pile-up, gap overflow and Type 1.5 migration in circumbinary discs: Application to supermassive black hole binaries","extern":"1","page":"2680-2700","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","doi":"10.1111/j.1365-2966.2012.22118.x","publisher":"Oxford University Press"},{"title":"Feedback from the infrared background in the early universe","year":"2012","extern":"1","page":"L51-L55","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","doi":"10.1111/j.1745-3933.2012.01298.x","publisher":"Oxford University Press","author":[{"full_name":"Wolcott-Green, J.","first_name":"J.","last_name":"Wolcott-Green"},{"full_name":"Haiman, Zoltán","id":"7c006e8c-cc0d-11ee-8322-cb904ef76f36","first_name":"Zoltán","last_name":"Haiman"}],"main_file_link":[{"url":"https://doi.org/10.1111/j.1745-3933.2012.01298.x","open_access":"1"}],"status":"public","month":"09","article_type":"original","issue":"1","_id":"17636","publication_status":"published","quality_controlled":"1","type":"journal_article","abstract":[{"lang":"eng","text":"It is commonly believed that the earliest stages of star formation in the Universe were self-regulated by global radiation backgrounds - either by the ultraviolet (UV) Lyman-Werner (LW) photons emitted by the first stars (directly photodissociating H2), or by the X-rays produced by accretion on to the black hole (BH) remnants of these stars (heating the gas but catalysing H2 formation). Recent studies have suggested that a significant fraction of the first stars may have had low masses (a few M⊙). Such stars do not leave BH remnants and they have softer spectra, with copious infrared (IR) radiation at photon energies ∼1 eV. Similar to LW and X-ray photons, these photons have a mean-free path comparable to the Hubble distance, building up an early IR background. Here we show that if soft-spectrum stars, with masses of a few M⊙, contributed ≳0.3 per cent of the UV background (or their mass fraction exceeded ∼80 per cent), then their IR radiation dominated radiative feedback in the early Universe. The feedback is different from the UV feedback from high-mass stars, and occurs through the photodetachment of H− ions, necessary for efficient H2 formation. Nevertheless, we find that the baryon fraction which must be incorporated into low-mass stars in order to suppress H2 cooling is only a factor of a few higher than for high-mass stars."}],"date_created":"2024-09-06T07:07:07Z","date_updated":"2024-09-24T11:29:36Z","oa":1,"citation":{"ama":"Wolcott-Green J, Haiman Z. Feedback from the infrared background in the early universe. <i>Monthly Notices of the Royal Astronomical Society: Letters</i>. 2012;425(1):L51-L55. doi:<a href=\"https://doi.org/10.1111/j.1745-3933.2012.01298.x\">10.1111/j.1745-3933.2012.01298.x</a>","short":"J. Wolcott-Green, Z. Haiman, Monthly Notices of the Royal Astronomical Society: Letters 425 (2012) L51–L55.","ista":"Wolcott-Green J, Haiman Z. 2012. Feedback from the infrared background in the early universe. Monthly Notices of the Royal Astronomical Society: Letters. 425(1), L51–L55.","apa":"Wolcott-Green, J., &#38; Haiman, Z. (2012). Feedback from the infrared background in the early universe. <i>Monthly Notices of the Royal Astronomical Society: Letters</i>. Oxford University Press. <a href=\"https://doi.org/10.1111/j.1745-3933.2012.01298.x\">https://doi.org/10.1111/j.1745-3933.2012.01298.x</a>","chicago":"Wolcott-Green, J., and Zoltán Haiman. “Feedback from the Infrared Background in the Early Universe.” <i>Monthly Notices of the Royal Astronomical Society: Letters</i>. Oxford University Press, 2012. <a href=\"https://doi.org/10.1111/j.1745-3933.2012.01298.x\">https://doi.org/10.1111/j.1745-3933.2012.01298.x</a>.","ieee":"J. Wolcott-Green and Z. Haiman, “Feedback from the infrared background in the early universe,” <i>Monthly Notices of the Royal Astronomical Society: Letters</i>, vol. 425, no. 1. Oxford University Press, pp. L51–L55, 2012.","mla":"Wolcott-Green, J., and Zoltán Haiman. “Feedback from the Infrared Background in the Early Universe.” <i>Monthly Notices of the Royal Astronomical Society: Letters</i>, vol. 425, no. 1, Oxford University Press, 2012, pp. L51–55, doi:<a href=\"https://doi.org/10.1111/j.1745-3933.2012.01298.x\">10.1111/j.1745-3933.2012.01298.x</a>."},"article_processing_charge":"No","oa_version":"Published Version","scopus_import":"1","publication_identifier":{"issn":["1745-3925","1745-3933"]},"date_published":"2012-09-01T00:00:00Z","volume":425,"language":[{"iso":"eng"}],"day":"01","intvolume":"       425","publication":"Monthly Notices of the Royal Astronomical Society: Letters"}]