---
_id: '1976'
abstract:
- lang: eng
  text: 'Complex I is a key enzyme of the respiratory chain in many organisms. This
    multi-protein complex with an intricate evolutionary history originated from the
    unification of prebuilt modules of hydrogenases and transporters. Using recently
    determined crystallographic structures of complex I we reanalyzed evolutionarily
    related complexes that couple oxidoreduction to trans-membrane ion translocation.
    Our analysis points to the previously unnoticed structural homology of the electron
    input module of formate dehydrogenlyases and subunit NuoG of complex I. We also
    show that all related to complex I hydrogenases likely operate via a conformation
    driven mechanism with structural changes generated in the conserved coupling site
    located at the interface of subunits NuoB/D/H. The coupling apparently originated
    once in evolutionary history, together with subunit NuoH joining hydrogenase and
    transport modules. Analysis of quinone oxidoreduction properties and the structure
    of complex I allows us to suggest a fully reversible coupling mechanism. Our model
    predicts that: 1) proton access to the ketone groups of the bound quinone is rigorously
    controlled by the protein, 2) the negative electric charge of the anionic ubiquinol
    head group is a major driving force for conformational changes.'
acknowledgement: The work in authors' laboratory was funded by the Medical Research
  Council.
author:
- first_name: Rouslan
  full_name: Efremov, Rouslan G
  last_name: Efremov
- first_name: Leonid A
  full_name: Leonid Sazanov
  id: 338D39FE-F248-11E8-B48F-1D18A9856A87
  last_name: Sazanov
  orcid: 0000-0002-0977-7989
citation:
  ama: Efremov R, Sazanov LA. The coupling mechanism of respiratory complex i - A
    structural and evolutionary perspective. <i>Biochimica et Biophysica Acta - Bioenergetics</i>.
    2012;1817(10):1785-1795. doi:<a href="https://doi.org/10.1016/j.bbabio.2012.02.015">10.1016/j.bbabio.2012.02.015</a>
  apa: Efremov, R., &#38; Sazanov, L. A. (2012). The coupling mechanism of respiratory
    complex i - A structural and evolutionary perspective. <i>Biochimica et Biophysica
    Acta - Bioenergetics</i>. Elsevier. <a href="https://doi.org/10.1016/j.bbabio.2012.02.015">https://doi.org/10.1016/j.bbabio.2012.02.015</a>
  chicago: Efremov, Rouslan, and Leonid A Sazanov. “The Coupling Mechanism of Respiratory
    Complex i - A Structural and Evolutionary Perspective.” <i>Biochimica et Biophysica
    Acta - Bioenergetics</i>. Elsevier, 2012. <a href="https://doi.org/10.1016/j.bbabio.2012.02.015">https://doi.org/10.1016/j.bbabio.2012.02.015</a>.
  ieee: R. Efremov and L. A. Sazanov, “The coupling mechanism of respiratory complex
    i - A structural and evolutionary perspective,” <i>Biochimica et Biophysica Acta
    - Bioenergetics</i>, vol. 1817, no. 10. Elsevier, pp. 1785–1795, 2012.
  ista: Efremov R, Sazanov LA. 2012. The coupling mechanism of respiratory complex
    i - A structural and evolutionary perspective. Biochimica et Biophysica Acta -
    Bioenergetics. 1817(10), 1785–1795.
  mla: Efremov, Rouslan, and Leonid A. Sazanov. “The Coupling Mechanism of Respiratory
    Complex i - A Structural and Evolutionary Perspective.” <i>Biochimica et Biophysica
    Acta - Bioenergetics</i>, vol. 1817, no. 10, Elsevier, 2012, pp. 1785–95, doi:<a
    href="https://doi.org/10.1016/j.bbabio.2012.02.015">10.1016/j.bbabio.2012.02.015</a>.
  short: R. Efremov, L.A. Sazanov, Biochimica et Biophysica Acta - Bioenergetics 1817
    (2012) 1785–1795.
date_created: 2018-12-11T11:55:00Z
date_published: 2012-10-01T00:00:00Z
date_updated: 2019-04-26T07:22:06Z
day: '01'
doi: 10.1016/j.bbabio.2012.02.015
extern: 1
intvolume: '      1817'
issue: '10'
month: '10'
page: 1785 - 1795
publication: Biochimica et Biophysica Acta - Bioenergetics
publication_status: published
publisher: Elsevier
publist_id: '5108'
quality_controlled: 0
status: public
title: The coupling mechanism of respiratory complex i - A structural and evolutionary
  perspective
type: review
volume: 1817
year: '2012'
...
---
_id: '492'
abstract:
- lang: eng
  text: 'Background: Characterizing root system architecture (RSA) is essential to
    understanding the development and function of vascular plants. Identifying RSA-associated
    genes also represents an underexplored opportunity for crop improvement. Software
    tools are needed to accelerate the pace at which quantitative traits of RSA are
    estimated from images of root networks.Results: We have developed GiA Roots (General
    Image Analysis of Roots), a semi-automated software tool designed specifically
    for the high-throughput analysis of root system images. GiA Roots includes user-assisted
    algorithms to distinguish root from background and a fully automated pipeline
    that extracts dozens of root system phenotypes. Quantitative information on each
    phenotype, along with intermediate steps for full reproducibility, is returned
    to the end-user for downstream analysis. GiA Roots has a GUI front end and a command-line
    interface for interweaving the software into large-scale workflows. GiA Roots
    can also be extended to estimate novel phenotypes specified by the end-user.Conclusions:
    We demonstrate the use of GiA Roots on a set of 2393 images of rice roots representing
    12 genotypes from the species Oryza sativa. We validate trait measurements against
    prior analyses of this image set that demonstrated that RSA traits are likely
    heritable and associated with genotypic differences. Moreover, we demonstrate
    that GiA Roots is extensible and an end-user can add functionality so that GiA
    Roots can estimate novel RSA traits. In summary, we show that the software can
    function as an efficient tool as part of a workflow to move from large numbers
    of root images to downstream analysis.'
article_number: '116'
article_processing_charge: No
author:
- first_name: Taras
  full_name: Galkovskyi, Taras
  last_name: Galkovskyi
- first_name: Yuriy
  full_name: Mileyko, Yuriy
  last_name: Mileyko
- first_name: Alexander
  full_name: Bucksch, Alexander
  last_name: Bucksch
- first_name: Brad
  full_name: Moore, Brad
  last_name: Moore
- first_name: Olga
  full_name: Symonova, Olga
  id: 3C0C7BC6-F248-11E8-B48F-1D18A9856A87
  last_name: Symonova
  orcid: 0000-0003-2012-9947
- first_name: Charles
  full_name: Price, Charles
  last_name: Price
- first_name: Chrostopher
  full_name: Topp, Chrostopher
  last_name: Topp
- first_name: Anjali
  full_name: Iyer Pascuzzi, Anjali
  last_name: Iyer Pascuzzi
- first_name: Paul
  full_name: Zurek, Paul
  last_name: Zurek
- first_name: Suqin
  full_name: Fang, Suqin
  last_name: Fang
- first_name: John
  full_name: Harer, John
  last_name: Harer
- first_name: Philip
  full_name: Benfey, Philip
  last_name: Benfey
- first_name: Joshua
  full_name: Weitz, Joshua
  last_name: Weitz
citation:
  ama: 'Galkovskyi T, Mileyko Y, Bucksch A, et al. GiA Roots: Software for the high
    throughput analysis of plant root system architecture. <i>BMC Plant Biology</i>.
    2012;12. doi:<a href="https://doi.org/10.1186/1471-2229-12-116">10.1186/1471-2229-12-116</a>'
  apa: 'Galkovskyi, T., Mileyko, Y., Bucksch, A., Moore, B., Symonova, O., Price,
    C., … Weitz, J. (2012). GiA Roots: Software for the high throughput analysis of
    plant root system architecture. <i>BMC Plant Biology</i>. BioMed Central. <a href="https://doi.org/10.1186/1471-2229-12-116">https://doi.org/10.1186/1471-2229-12-116</a>'
  chicago: 'Galkovskyi, Taras, Yuriy Mileyko, Alexander Bucksch, Brad Moore, Olga
    Symonova, Charles Price, Chrostopher Topp, et al. “GiA Roots: Software for the
    High Throughput Analysis of Plant Root System Architecture.” <i>BMC Plant Biology</i>.
    BioMed Central, 2012. <a href="https://doi.org/10.1186/1471-2229-12-116">https://doi.org/10.1186/1471-2229-12-116</a>.'
  ieee: 'T. Galkovskyi <i>et al.</i>, “GiA Roots: Software for the high throughput
    analysis of plant root system architecture,” <i>BMC Plant Biology</i>, vol. 12.
    BioMed Central, 2012.'
  ista: 'Galkovskyi T, Mileyko Y, Bucksch A, Moore B, Symonova O, Price C, Topp C,
    Iyer Pascuzzi A, Zurek P, Fang S, Harer J, Benfey P, Weitz J. 2012. GiA Roots:
    Software for the high throughput analysis of plant root system architecture. BMC
    Plant Biology. 12, 116.'
  mla: 'Galkovskyi, Taras, et al. “GiA Roots: Software for the High Throughput Analysis
    of Plant Root System Architecture.” <i>BMC Plant Biology</i>, vol. 12, 116, BioMed
    Central, 2012, doi:<a href="https://doi.org/10.1186/1471-2229-12-116">10.1186/1471-2229-12-116</a>.'
  short: T. Galkovskyi, Y. Mileyko, A. Bucksch, B. Moore, O. Symonova, C. Price, C.
    Topp, A. Iyer Pascuzzi, P. Zurek, S. Fang, J. Harer, P. Benfey, J. Weitz, BMC
    Plant Biology 12 (2012).
date_created: 2018-12-11T11:46:46Z
date_published: 2012-07-26T00:00:00Z
date_updated: 2025-09-30T08:36:34Z
day: '26'
ddc:
- '005'
- '514'
- '516'
doi: 10.1186/1471-2229-12-116
extern: '1'
external_id:
  isi:
  - '000309114300001'
file:
- access_level: open_access
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  creator: system
  date_created: 2018-12-12T10:12:35Z
  date_updated: 2020-07-14T12:46:35Z
  file_id: '4953'
  file_name: IST-2018-946-v1+1_2012_Symonova_GiA_Roots.pdf
  file_size: 1691436
  relation: main_file
file_date_updated: 2020-07-14T12:46:35Z
has_accepted_license: '1'
intvolume: '        12'
isi: 1
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '07'
oa: 1
oa_version: Published Version
publication: BMC Plant Biology
publication_status: published
publisher: BioMed Central
publist_id: '7328'
pubrep_id: '946'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'GiA Roots: Software for the high throughput analysis of plant root system
  architecture'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 12
year: '2012'
...
---
_id: '493'
abstract:
- lang: eng
  text: 'The BCI competition IV stands in the tradition of prior BCI competitions
    that aim to provide high quality neuroscientific data for open access to the scientific
    community. As experienced already in prior competitions not only scientists from
    the narrow field of BCI compete, but scholars with a broad variety of backgrounds
    and nationalities. They include high specialists as well as students.The goals
    of all BCI competitions have always been to challenge with respect to novel paradigms
    and complex data. We report on the following challenges: (1) asynchronous data,
    (2) synthetic, (3) multi-class continuous data, (4) sessionto-session transfer,
    (5) directionally modulated MEG, (6) finger movements recorded by ECoG. As after
    past competitions, our hope is that winning entries may enhance the analysis methods
    of future BCIs.'
acknowledgement: "The studies were in part or completely supported by the Bundesministerium
  für Bildung und Forschung (BMBF), Fkz 01IB001A, 01GQ0850, by the German Science
  Foundation (DFG, contract MU 987/3-2), by the European ICT Programme Projects FP7-224631
  and 216886, the World Class University Program through the National Research Foundation
  of Korea funded by the Ministry of Education, Science, and Technology (Grant R31-10008),
  the US Army Research Office [W911NF-08-1-0216 (Gerwin Schalk) and W911NF-07-1-0415
  (Gerwin Schalk)] and the NIH [EB006356 (Gerwin Schalk) and EB000856 (Gerwin Schalk),
  the WIN-Kolleg of the Heidelberg Academy of Sciences and Humanities, German Federal
  Ministry of Education and Research grants 01GQ0420, 01GQ0761, 01GQ0762, and 01GQ0830,
  German Research Foundation grants 550/B5 and C6, and by a scholarship from the German
  National Academic Foundation. This paper only reflects the authors’ views and funding
  agencies are not liable for any use that may be made of the information contained
  herein.\r\n"
article_number: '55'
article_processing_charge: No
author:
- first_name: Michael
  full_name: Tangermann, Michael
  last_name: Tangermann
- first_name: Klaus
  full_name: Müller, Klaus
  last_name: Müller
- first_name: Ad
  full_name: Aertsen, Ad
  last_name: Aertsen
- first_name: Niels
  full_name: Birbaumer, Niels
  last_name: Birbaumer
- first_name: Christoph
  full_name: Braun, Christoph
  last_name: Braun
- first_name: Clemens
  full_name: Brunner, Clemens
  last_name: Brunner
- first_name: Robert
  full_name: Leeb, Robert
  last_name: Leeb
- first_name: Carsten
  full_name: Mehring, Carsten
  last_name: Mehring
- first_name: Kai
  full_name: Miller, Kai
  last_name: Miller
- first_name: Gernot
  full_name: Müller Putz, Gernot
  last_name: Müller Putz
- first_name: Guido
  full_name: Nolte, Guido
  last_name: Nolte
- first_name: Gert
  full_name: Pfurtscheller, Gert
  last_name: Pfurtscheller
- first_name: Hubert
  full_name: Preissl, Hubert
  last_name: Preissl
- first_name: Gerwin
  full_name: Schalk, Gerwin
  last_name: Schalk
- first_name: Alois
  full_name: Schlögl, Alois
  id: 45BF87EE-F248-11E8-B48F-1D18A9856A87
  last_name: Schlögl
  orcid: 0000-0002-5621-8100
- first_name: Carmen
  full_name: Vidaurre, Carmen
  last_name: Vidaurre
- first_name: Stephan
  full_name: Waldert, Stephan
  last_name: Waldert
- first_name: Benjamin
  full_name: Blankertz, Benjamin
  last_name: Blankertz
citation:
  ama: Tangermann M, Müller K, Aertsen A, et al. Review of the BCI competition IV.
    <i>Frontiers in Neuroscience</i>. 2012;6. doi:<a href="https://doi.org/10.3389/fnins.2012.00055">10.3389/fnins.2012.00055</a>
  apa: Tangermann, M., Müller, K., Aertsen, A., Birbaumer, N., Braun, C., Brunner,
    C., … Blankertz, B. (2012). Review of the BCI competition IV. <i>Frontiers in
    Neuroscience</i>. Frontiers Research Foundation. <a href="https://doi.org/10.3389/fnins.2012.00055">https://doi.org/10.3389/fnins.2012.00055</a>
  chicago: Tangermann, Michael, Klaus Müller, Ad Aertsen, Niels Birbaumer, Christoph
    Braun, Clemens Brunner, Robert Leeb, et al. “Review of the BCI Competition IV.”
    <i>Frontiers in Neuroscience</i>. Frontiers Research Foundation, 2012. <a href="https://doi.org/10.3389/fnins.2012.00055">https://doi.org/10.3389/fnins.2012.00055</a>.
  ieee: M. Tangermann <i>et al.</i>, “Review of the BCI competition IV,” <i>Frontiers
    in Neuroscience</i>, vol. 6. Frontiers Research Foundation, 2012.
  ista: Tangermann M, Müller K, Aertsen A, Birbaumer N, Braun C, Brunner C, Leeb R,
    Mehring C, Miller K, Müller Putz G, Nolte G, Pfurtscheller G, Preissl H, Schalk
    G, Schlögl A, Vidaurre C, Waldert S, Blankertz B. 2012. Review of the BCI competition
    IV. Frontiers in Neuroscience. 6, 55.
  mla: Tangermann, Michael, et al. “Review of the BCI Competition IV.” <i>Frontiers
    in Neuroscience</i>, vol. 6, 55, Frontiers Research Foundation, 2012, doi:<a href="https://doi.org/10.3389/fnins.2012.00055">10.3389/fnins.2012.00055</a>.
  short: M. Tangermann, K. Müller, A. Aertsen, N. Birbaumer, C. Braun, C. Brunner,
    R. Leeb, C. Mehring, K. Miller, G. Müller Putz, G. Nolte, G. Pfurtscheller, H.
    Preissl, G. Schalk, A. Schlögl, C. Vidaurre, S. Waldert, B. Blankertz, Frontiers
    in Neuroscience 6 (2012).
date_created: 2018-12-11T11:46:46Z
date_published: 2012-07-13T00:00:00Z
date_updated: 2025-09-30T08:35:59Z
day: '13'
ddc:
- '004'
department:
- _id: ScienComp
- _id: PeJo
doi: 10.3389/fnins.2012.00055
external_id:
  isi:
  - '000209165300066'
file:
- access_level: open_access
  checksum: 195238221c4b0b0f4035f6f6c16ea17c
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:18:34Z
  date_updated: 2020-07-14T12:46:35Z
  file_id: '5356'
  file_name: IST-2018-945-v1+1_2012_Schloegl_Review_of.pdf
  file_size: 2693701
  relation: main_file
file_date_updated: 2020-07-14T12:46:35Z
has_accepted_license: '1'
intvolume: '         6'
isi: 1
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
publication: Frontiers in Neuroscience
publication_status: published
publisher: Frontiers Research Foundation
publist_id: '7327'
pubrep_id: '945'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Review of the BCI competition IV
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 6
year: '2012'
...
---
_id: '495'
abstract:
- lang: eng
  text: An automaton with advice is a finite state automaton which has access to an
    additional fixed infinite string called an advice tape. We refine the Myhill-Nerode
    theorem to characterize the languages of finite strings that are accepted by automata
    with advice. We do the same for tree automata with advice.
alternative_title:
- EPTCS
author:
- first_name: Alex
  full_name: Kruckman, Alex
  last_name: Kruckman
- first_name: Sasha
  full_name: Rubin, Sasha
  id: 2EC51194-F248-11E8-B48F-1D18A9856A87
  last_name: Rubin
- first_name: John
  full_name: Sheridan, John
  last_name: Sheridan
- first_name: Ben
  full_name: Zax, Ben
  last_name: Zax
citation:
  ama: 'Kruckman A, Rubin S, Sheridan J, Zax B. A Myhill Nerode theorem for automata
    with advice. In: <i>Proceedings GandALF 2012</i>. Vol 96. Open Publishing Association;
    2012:238-246. doi:<a href="https://doi.org/10.4204/EPTCS.96.18">10.4204/EPTCS.96.18</a>'
  apa: 'Kruckman, A., Rubin, S., Sheridan, J., &#38; Zax, B. (2012). A Myhill Nerode
    theorem for automata with advice. In <i>Proceedings GandALF 2012</i> (Vol. 96,
    pp. 238–246). Napoli, Italy: Open Publishing Association. <a href="https://doi.org/10.4204/EPTCS.96.18">https://doi.org/10.4204/EPTCS.96.18</a>'
  chicago: Kruckman, Alex, Sasha Rubin, John Sheridan, and Ben Zax. “A Myhill Nerode
    Theorem for Automata with Advice.” In <i>Proceedings GandALF 2012</i>, 96:238–46.
    Open Publishing Association, 2012. <a href="https://doi.org/10.4204/EPTCS.96.18">https://doi.org/10.4204/EPTCS.96.18</a>.
  ieee: A. Kruckman, S. Rubin, J. Sheridan, and B. Zax, “A Myhill Nerode theorem for
    automata with advice,” in <i>Proceedings GandALF 2012</i>, Napoli, Italy, 2012,
    vol. 96, pp. 238–246.
  ista: 'Kruckman A, Rubin S, Sheridan J, Zax B. 2012. A Myhill Nerode theorem for
    automata with advice. Proceedings GandALF 2012. GandALF: Games, Automata, Logics
    and Formal Verification, EPTCS, vol. 96, 238–246.'
  mla: Kruckman, Alex, et al. “A Myhill Nerode Theorem for Automata with Advice.”
    <i>Proceedings GandALF 2012</i>, vol. 96, Open Publishing Association, 2012, pp.
    238–46, doi:<a href="https://doi.org/10.4204/EPTCS.96.18">10.4204/EPTCS.96.18</a>.
  short: A. Kruckman, S. Rubin, J. Sheridan, B. Zax, in:, Proceedings GandALF 2012,
    Open Publishing Association, 2012, pp. 238–246.
conference:
  end_date: 2012-09-08
  location: Napoli, Italy
  name: 'GandALF: Games, Automata, Logics and Formal Verification'
  start_date: 2012-09-06
corr_author: '1'
date_created: 2018-12-11T11:46:47Z
date_published: 2012-10-07T00:00:00Z
date_updated: 2024-10-09T20:55:00Z
day: '07'
ddc:
- '004'
department:
- _id: KrCh
doi: 10.4204/EPTCS.96.18
ec_funded: 1
file:
- access_level: open_access
  checksum: 56277f95edc9d531fa3bdc5f9579fda8
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:15:31Z
  date_updated: 2020-07-14T12:46:35Z
  file_id: '5152'
  file_name: IST-2018-944-v1+1_2012_Rubin_A_Myhill.pdf
  file_size: 97736
  relation: main_file
file_date_updated: 2020-07-14T12:46:35Z
has_accepted_license: '1'
intvolume: '        96'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
page: 238 - 246
project:
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S 11407_N23
  name: Rigorous Systems Engineering
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '279307'
  name: 'Quantitative Graph Games: Theory and Applications'
publication: Proceedings GandALF 2012
publication_status: published
publisher: Open Publishing Association
publist_id: '7325'
pubrep_id: '944'
quality_controlled: '1'
scopus_import: 1
status: public
title: A Myhill Nerode theorem for automata with advice
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: conference
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 96
year: '2012'
...
---
_id: '496'
abstract:
- lang: eng
  text: 'We study the expressive power of logical interpretations on the class of
    scattered trees, namely those with countably many infinite branches. Scattered
    trees can be thought of as the tree analogue of scattered linear orders. Every
    scattered tree has an ordinal rank that reflects the structure of its infinite
    branches. We prove, roughly, that trees and orders of large rank cannot be interpreted
    in scattered trees of small rank. We consider a quite general notion of interpretation:
    each element of the interpreted structure is represented by a set of tuples of
    subsets of the interpreting tree. Our trees are countable, not necessarily finitely
    branching, and may have finitely many unary predicates as labellings. We also
    show how to replace injective set-interpretations in (not necessarily scattered)
    trees by ''finitary'' set-interpretations.'
alternative_title:
- LICS
article_number: '6280474'
article_processing_charge: No
author:
- first_name: Alexander
  full_name: Rabinovich, Alexander
  last_name: Rabinovich
- first_name: Sasha
  full_name: Rubin, Sasha
  id: 2EC51194-F248-11E8-B48F-1D18A9856A87
  last_name: Rubin
citation:
  ama: 'Rabinovich A, Rubin S. Interpretations in trees with countably many branches.
    In: IEEE; 2012. doi:<a href="https://doi.org/10.1109/LICS.2012.65">10.1109/LICS.2012.65</a>'
  apa: 'Rabinovich, A., &#38; Rubin, S. (2012). Interpretations in trees with countably
    many branches. Presented at the LICS: Logic in Computer Science, Dubrovnik, Croatia:
    IEEE. <a href="https://doi.org/10.1109/LICS.2012.65">https://doi.org/10.1109/LICS.2012.65</a>'
  chicago: Rabinovich, Alexander, and Sasha Rubin. “Interpretations in Trees with
    Countably Many Branches.” IEEE, 2012. <a href="https://doi.org/10.1109/LICS.2012.65">https://doi.org/10.1109/LICS.2012.65</a>.
  ieee: 'A. Rabinovich and S. Rubin, “Interpretations in trees with countably many
    branches,” presented at the LICS: Logic in Computer Science, Dubrovnik, Croatia,
    2012.'
  ista: 'Rabinovich A, Rubin S. 2012. Interpretations in trees with countably many
    branches. LICS: Logic in Computer Science, LICS, , 6280474.'
  mla: Rabinovich, Alexander, and Sasha Rubin. <i>Interpretations in Trees with Countably
    Many Branches</i>. 6280474, IEEE, 2012, doi:<a href="https://doi.org/10.1109/LICS.2012.65">10.1109/LICS.2012.65</a>.
  short: A. Rabinovich, S. Rubin, in:, IEEE, 2012.
conference:
  end_date: 2012-06-28
  location: Dubrovnik, Croatia
  name: 'LICS: Logic in Computer Science'
  start_date: 2012-06-25
date_created: 2018-12-11T11:46:47Z
date_published: 2012-01-01T00:00:00Z
date_updated: 2025-09-30T08:34:47Z
day: '01'
department:
- _id: KrCh
doi: 10.1109/LICS.2012.65
ec_funded: 1
external_id:
  isi:
  - '000309059900061'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arise.or.at/pubpdf/Interpretations_in_Trees_with_Countably_Many_Branches.pdf
month: '01'
oa: 1
oa_version: Preprint
project:
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '279307'
  name: 'Quantitative Graph Games: Theory and Applications'
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S 11407_N23
  name: Rigorous Systems Engineering
publication_status: published
publisher: IEEE
publist_id: '7324'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Interpretations in trees with countably many branches
type: conference
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
year: '2012'
...
---
_id: '497'
abstract:
- lang: eng
  text: 'One central issue in the formal design and analysis of reactive systems is
    the notion of refinement that asks whether all behaviors of the implementation
    is allowed by the specification. The local interpretation of behavior leads to
    the notion of simulation. Alternating transition systems (ATSs) provide a general
    model for composite reactive systems, and the simulation relation for ATSs is
    known as alternating simulation. The simulation relation for fair transition systems
    is called fair simulation. In this work our main contributions are as follows:
    (1) We present an improved algorithm for fair simulation with Büchi fairness constraints;
    our algorithm requires O(n 3·m) time as compared to the previous known O(n 6)-time
    algorithm, where n is the number of states and m is the number of transitions.
    (2) We present a game based algorithm for alternating simulation that requires
    O(m2)-time as compared to the previous known O((n·m)2)-time algorithm, where n
    is the number of states and m is the size of transition relation. (3) We present
    an iterative algorithm for alternating simulation that matches the time complexity
    of the game based algorithm, but is more space efficient than the game based algorithm.
    © Krishnendu Chatterjee, Siddhesh Chaubal, and Pritish Kamath.'
alternative_title:
- LIPIcs
author:
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Siddhesh
  full_name: Chaubal, Siddhesh
  last_name: Chaubal
- first_name: Pritish
  full_name: Kamath, Pritish
  last_name: Kamath
citation:
  ama: 'Chatterjee K, Chaubal S, Kamath P. Faster algorithms for alternating refinement
    relations. In: Vol 16. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2012:167-182.
    doi:<a href="https://doi.org/10.4230/LIPIcs.CSL.2012.167">10.4230/LIPIcs.CSL.2012.167</a>'
  apa: 'Chatterjee, K., Chaubal, S., &#38; Kamath, P. (2012). Faster algorithms for
    alternating refinement relations (Vol. 16, pp. 167–182). Presented at the EACSL:
    European Association for Computer Science Logic, Fontainebleau, France: Schloss
    Dagstuhl - Leibniz-Zentrum für Informatik. <a href="https://doi.org/10.4230/LIPIcs.CSL.2012.167">https://doi.org/10.4230/LIPIcs.CSL.2012.167</a>'
  chicago: Chatterjee, Krishnendu, Siddhesh Chaubal, and Pritish Kamath. “Faster Algorithms
    for Alternating Refinement Relations,” 16:167–82. Schloss Dagstuhl - Leibniz-Zentrum
    für Informatik, 2012. <a href="https://doi.org/10.4230/LIPIcs.CSL.2012.167">https://doi.org/10.4230/LIPIcs.CSL.2012.167</a>.
  ieee: 'K. Chatterjee, S. Chaubal, and P. Kamath, “Faster algorithms for alternating
    refinement relations,” presented at the EACSL: European Association for Computer
    Science Logic, Fontainebleau, France, 2012, vol. 16, pp. 167–182.'
  ista: 'Chatterjee K, Chaubal S, Kamath P. 2012. Faster algorithms for alternating
    refinement relations. EACSL: European Association for Computer Science Logic,
    LIPIcs, vol. 16, 167–182.'
  mla: Chatterjee, Krishnendu, et al. <i>Faster Algorithms for Alternating Refinement
    Relations</i>. Vol. 16, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2012,
    pp. 167–82, doi:<a href="https://doi.org/10.4230/LIPIcs.CSL.2012.167">10.4230/LIPIcs.CSL.2012.167</a>.
  short: K. Chatterjee, S. Chaubal, P. Kamath, in:, Schloss Dagstuhl - Leibniz-Zentrum
    für Informatik, 2012, pp. 167–182.
conference:
  end_date: 2012-09-06
  location: Fontainebleau, France
  name: 'EACSL: European Association for Computer Science Logic'
  start_date: 2012-09-03
date_created: 2018-12-11T11:46:48Z
date_published: 2012-09-01T00:00:00Z
date_updated: 2025-01-14T12:24:50Z
day: '01'
ddc:
- '004'
department:
- _id: KrCh
doi: 10.4230/LIPIcs.CSL.2012.167
ec_funded: 1
file:
- access_level: open_access
  checksum: f1b0dd99240800db2d7dbf9b5131fe5e
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:08:50Z
  date_updated: 2020-07-14T12:46:35Z
  file_id: '4712'
  file_name: IST-2018-943-v1+1_2012_Chatterjee_Faster_Algorithms.pdf
  file_size: 471236
  relation: main_file
file_date_updated: 2020-07-14T12:46:35Z
has_accepted_license: '1'
intvolume: '        16'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '09'
oa: 1
oa_version: Published Version
page: 167 - 182
project:
- _id: 2584A770-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P 23499-N23
  name: Modern Graph Algorithmic Techniques in Formal Verification
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S 11407_N23
  name: Rigorous Systems Engineering
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '279307'
  name: 'Quantitative Graph Games: Theory and Applications'
- _id: 2587B514-B435-11E9-9278-68D0E5697425
  name: Microsoft Research Faculty Fellowship
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
publist_id: '7323'
pubrep_id: '943'
quality_controlled: '1'
related_material:
  record:
  - id: '5378'
    relation: earlier_version
    status: public
scopus_import: 1
status: public
title: Faster algorithms for alternating refinement relations
tmp:
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  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: conference
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 16
year: '2012'
...
---
_id: '498'
abstract:
- lang: eng
  text: Understanding patterns and correlates of local adaptation in heterogeneous
    landscapes can provide important information in the selection of appropriate seed
    sources for restoration. We assessed the extent of local adaptation of fitness
    components in 12 population pairs of the perennial herb Rutidosis leptorrhynchoides
    (Asteraceae) and examined whether spatial scale (0.7-600 km), environmental distance,
    quantitative (QST) and neutral (FST) genetic differentiation, and size of the
    local and foreign populations could predict patterns of adaptive differentiation.
    Local adaptation varied among populations and fitness components. Including all
    population pairs, local adaptation was observed for seedling survival, but not
    for biomass, while foreign genotype advantage was observed for reproduction (number
    of inflorescences). Among population pairs, local adaptation increased with QST
    and local population size for biomass. QST was associated with environmental distance,
    suggesting ecological selection for phenotypic divergence. However, low FST and
    variation in population structure in small populations demonstrates the interaction
    of gene flow and drift in constraining local adaptation in R. leptorrhynchoides.
    Our study indicates that for species in heterogeneous landscapes, collecting seed
    from large populations from similar environments to candidate sites is likely
    to provide the most appropriate seed sources for restoration.
acknowledgement: "We thank Graham Pickup, David Steer, Linda Broadhurst, Lan Li and
  Carole Elliott for technical assistance. The New\r\nSouth Wales Department of Environment
  and Climate Change, ACT Parks, Conservation and Lands and the\r\nDepartment of Sustainability
  and Environment in Victoria provided permits for seed and soil collection. We thank\r\nSpencer
  C. H. Barrett for comments that improved the quality of the manuscript.\r\n"
article_processing_charge: No
author:
- first_name: Melinda
  full_name: Pickup, Melinda
  id: 2C78037E-F248-11E8-B48F-1D18A9856A87
  last_name: Pickup
  orcid: 0000-0001-6118-0541
- first_name: David
  full_name: Field, David
  id: 419049E2-F248-11E8-B48F-1D18A9856A87
  last_name: Field
  orcid: 0000-0002-4014-8478
- first_name: David
  full_name: Rowell, David
  last_name: Rowell
- first_name: Andrew
  full_name: Young, Andrew
  last_name: Young
citation:
  ama: 'Pickup M, Field D, Rowell D, Young A. Predicting local adaptation in fragmented
    plant populations: Implications for restoration genetics. <i>Evolutionary Applications</i>.
    2012;5(8):913-924. doi:<a href="https://doi.org/10.1111/j.1752-4571.2012.00284.x">10.1111/j.1752-4571.2012.00284.x</a>'
  apa: 'Pickup, M., Field, D., Rowell, D., &#38; Young, A. (2012). Predicting local
    adaptation in fragmented plant populations: Implications for restoration genetics.
    <i>Evolutionary Applications</i>. Wiley-Blackwell. <a href="https://doi.org/10.1111/j.1752-4571.2012.00284.x">https://doi.org/10.1111/j.1752-4571.2012.00284.x</a>'
  chicago: 'Pickup, Melinda, David Field, David Rowell, and Andrew Young. “Predicting
    Local Adaptation in Fragmented Plant Populations: Implications for Restoration
    Genetics.” <i>Evolutionary Applications</i>. Wiley-Blackwell, 2012. <a href="https://doi.org/10.1111/j.1752-4571.2012.00284.x">https://doi.org/10.1111/j.1752-4571.2012.00284.x</a>.'
  ieee: 'M. Pickup, D. Field, D. Rowell, and A. Young, “Predicting local adaptation
    in fragmented plant populations: Implications for restoration genetics,” <i>Evolutionary
    Applications</i>, vol. 5, no. 8. Wiley-Blackwell, pp. 913–924, 2012.'
  ista: 'Pickup M, Field D, Rowell D, Young A. 2012. Predicting local adaptation in
    fragmented plant populations: Implications for restoration genetics. Evolutionary
    Applications. 5(8), 913–924.'
  mla: 'Pickup, Melinda, et al. “Predicting Local Adaptation in Fragmented Plant Populations:
    Implications for Restoration Genetics.” <i>Evolutionary Applications</i>, vol.
    5, no. 8, Wiley-Blackwell, 2012, pp. 913–24, doi:<a href="https://doi.org/10.1111/j.1752-4571.2012.00284.x">10.1111/j.1752-4571.2012.00284.x</a>.'
  short: M. Pickup, D. Field, D. Rowell, A. Young, Evolutionary Applications 5 (2012)
    913–924.
corr_author: '1'
date_created: 2018-12-11T11:46:48Z
date_published: 2012-12-01T00:00:00Z
date_updated: 2025-09-30T08:33:55Z
day: '01'
ddc:
- '576'
department:
- _id: NiBa
doi: 10.1111/j.1752-4571.2012.00284.x
external_id:
  isi:
  - '000312808900013'
file:
- access_level: open_access
  checksum: 233007138606aca5a2f75f7ae1742f43
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:10:33Z
  date_updated: 2020-07-14T12:46:35Z
  file_id: '4821'
  file_name: IST-2018-942-v1+1_Pickup_et_al-2012-Evolutionary_Applications.pdf
  file_size: 396136
  relation: main_file
file_date_updated: 2020-07-14T12:46:35Z
has_accepted_license: '1'
intvolume: '         5'
isi: 1
issue: '8'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc/4.0/
month: '12'
oa: 1
oa_version: Published Version
page: 913 - 924
publication: Evolutionary Applications
publication_status: published
publisher: Wiley-Blackwell
publist_id: '7322'
pubrep_id: '942'
quality_controlled: '1'
status: public
title: 'Predicting local adaptation in fragmented plant populations: Implications
  for restoration genetics'
tmp:
  image: /images/cc_by_nc.png
  legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
  short: CC BY-NC (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 5
year: '2012'
...
---
_id: '5377'
abstract:
- lang: eng
  text: 'Two-player games on graphs are central in many problems in formal verification
    and program analysis such as synthesis and verification of open systems. In this
    work we consider solving recursive game graphs (or pushdown game graphs) that
    can model the control flow of sequential programs with recursion. While pushdown
    games have been studied before with qualitative objectives, such as reachability
    and ω-regular objectives, in this work we study for the first time such games
    with the most well-studied quantitative objective, namely, mean-payoff objectives.
    In pushdown games two types of strategies are relevant: (1) global strategies,
    that depend on the entire global history; and (2) modular strategies, that have
    only local memory and thus do not depend on the context of invocation, but only
    on the history of the current invocation of the module. Our main results are as
    follows: (1) One-player pushdown games with mean-payoff objectives under global
    strategies are decidable in polynomial time. (2) Two- player pushdown games with
    mean-payoff objectives under global strategies are undecidable. (3) One-player
    pushdown games with mean-payoff objectives under modular strategies are NP- hard.
    (4) Two-player pushdown games with mean-payoff objectives under modular strategies
    can be solved in NP (i.e., both one-player and two-player pushdown games with
    mean-payoff objectives under modular strategies are NP-complete). We also establish
    the optimal strategy complexity showing that global strategies for mean-payoff
    objectives require infinite memory even in one-player pushdown games; and memoryless
    modular strategies are sufficient in two- player pushdown games. Finally we also
    show that all the problems have the same complexity if the stack boundedness condition
    is added, where along with the mean-payoff objective the player must also ensure
    that the stack height is bounded.'
alternative_title:
- IST Austria Technical Report
article_processing_charge: No
author:
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Yaron
  full_name: Velner, Yaron
  last_name: Velner
citation:
  ama: Chatterjee K, Velner Y. <i>Mean-Payoff Pushdown Games</i>. IST Austria; 2012.
    doi:<a href="https://doi.org/10.15479/AT:IST-2012-0002">10.15479/AT:IST-2012-0002</a>
  apa: Chatterjee, K., &#38; Velner, Y. (2012). <i>Mean-payoff pushdown games</i>.
    IST Austria. <a href="https://doi.org/10.15479/AT:IST-2012-0002">https://doi.org/10.15479/AT:IST-2012-0002</a>
  chicago: Chatterjee, Krishnendu, and Yaron Velner. <i>Mean-Payoff Pushdown Games</i>.
    IST Austria, 2012. <a href="https://doi.org/10.15479/AT:IST-2012-0002">https://doi.org/10.15479/AT:IST-2012-0002</a>.
  ieee: K. Chatterjee and Y. Velner, <i>Mean-payoff pushdown games</i>. IST Austria,
    2012.
  ista: Chatterjee K, Velner Y. 2012. Mean-payoff pushdown games, IST Austria, 33p.
  mla: Chatterjee, Krishnendu, and Yaron Velner. <i>Mean-Payoff Pushdown Games</i>.
    IST Austria, 2012, doi:<a href="https://doi.org/10.15479/AT:IST-2012-0002">10.15479/AT:IST-2012-0002</a>.
  short: K. Chatterjee, Y. Velner, Mean-Payoff Pushdown Games, IST Austria, 2012.
corr_author: '1'
date_created: 2018-12-12T11:38:59Z
date_published: 2012-07-02T00:00:00Z
date_updated: 2025-09-30T08:08:12Z
day: '02'
ddc:
- '000'
- '005'
department:
- _id: KrCh
doi: 10.15479/AT:IST-2012-0002
file:
- access_level: open_access
  checksum: a03c08c1589dbb0c96183a8bcf3ab240
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T11:54:00Z
  date_updated: 2020-07-14T12:46:38Z
  file_id: '5522'
  file_name: IST-2012-002_IST-2012-0002.pdf
  file_size: 592098
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file_date_updated: 2020-07-14T12:46:38Z
has_accepted_license: '1'
language:
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month: '07'
oa: 1
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page: '33'
publication_identifier:
  issn:
  - 2664-1690
publication_status: published
publisher: IST Austria
pubrep_id: '10'
related_material:
  record:
  - id: '2956'
    relation: later_version
    status: public
status: public
title: Mean-payoff pushdown games
type: technical_report
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2012'
...
---
_id: '5378'
abstract:
- lang: eng
  text: 'One central issue in the formal design and analysis of reactive systems is
    the notion of refinement that asks whether all behaviors of the implementation
    is allowed by the specification. The local interpretation of behavior leads to
    the notion of simulation. Alternating transition systems (ATSs) provide a general
    model for composite reactive systems, and the simulation relation for ATSs is
    known as alternating simulation. The simulation relation for fair transition systems
    is called fair simulation. In this work our main contributions are as follows:
    (1) We present an improved algorithm for fair simulation with Büchi fairness constraints;
    our algorithm requires O(n3 · m) time as compared to the previous known O(n6)-time
    algorithm, where n is the number of states and m is the number of transitions.
    (2) We present a game based algorithm for alternating simulation that requires
    O(m2)-time as compared to the previous known O((n · m)2)-time algorithm, where
    n is the number of states and m is the size of transition relation. (3) We present
    an iterative algorithm for alternating simulation that matches the time complexity
    of the game based algorithm, but is more space efficient than the game based algorithm.'
alternative_title:
- IST Austria Technical Report
article_processing_charge: No
author:
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Siddhesh
  full_name: Chaubal, Siddhesh
  last_name: Chaubal
- first_name: Pritish
  full_name: Kamath, Pritish
  last_name: Kamath
citation:
  ama: Chatterjee K, Chaubal S, Kamath P. <i>Faster Algorithms for Alternating Refinement
    Relations</i>. IST Austria; 2012. doi:<a href="https://doi.org/10.15479/AT:IST-2012-0001">10.15479/AT:IST-2012-0001</a>
  apa: Chatterjee, K., Chaubal, S., &#38; Kamath, P. (2012). <i>Faster algorithms
    for alternating refinement relations</i>. IST Austria. <a href="https://doi.org/10.15479/AT:IST-2012-0001">https://doi.org/10.15479/AT:IST-2012-0001</a>
  chicago: Chatterjee, Krishnendu, Siddhesh Chaubal, and Pritish Kamath. <i>Faster
    Algorithms for Alternating Refinement Relations</i>. IST Austria, 2012. <a href="https://doi.org/10.15479/AT:IST-2012-0001">https://doi.org/10.15479/AT:IST-2012-0001</a>.
  ieee: K. Chatterjee, S. Chaubal, and P. Kamath, <i>Faster algorithms for alternating
    refinement relations</i>. IST Austria, 2012.
  ista: Chatterjee K, Chaubal S, Kamath P. 2012. Faster algorithms for alternating
    refinement relations, IST Austria, 21p.
  mla: Chatterjee, Krishnendu, et al. <i>Faster Algorithms for Alternating Refinement
    Relations</i>. IST Austria, 2012, doi:<a href="https://doi.org/10.15479/AT:IST-2012-0001">10.15479/AT:IST-2012-0001</a>.
  short: K. Chatterjee, S. Chaubal, P. Kamath, Faster Algorithms for Alternating Refinement
    Relations, IST Austria, 2012.
corr_author: '1'
date_created: 2018-12-12T11:38:59Z
date_published: 2012-07-04T00:00:00Z
date_updated: 2025-04-15T08:12:24Z
day: '04'
ddc:
- '000'
- '005'
department:
- _id: KrCh
doi: 10.15479/AT:IST-2012-0001
file:
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  checksum: ec8d1857cc7095d3de5107a0162ced37
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  file_size: 394256
  relation: main_file
file_date_updated: 2020-07-14T12:46:39Z
has_accepted_license: '1'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: '21'
publication_identifier:
  issn:
  - 2664-1690
publication_status: published
publisher: IST Austria
pubrep_id: '14'
related_material:
  record:
  - id: '497'
    relation: later_version
    status: public
status: public
title: Faster algorithms for alternating refinement relations
type: technical_report
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2012'
...
---
_id: '5396'
abstract:
- lang: eng
  text: We consider the problem of inference in agraphical model with binary variables.
    While in theory it is arguably preferable to compute marginal probabilities, in
    practice researchers often use MAP inference due to the availability of efficient
    discrete optimization algorithms. We bridge the gap between the two approaches
    by introducing the Discrete  Marginals technique in which approximate marginals
    are obtained by minimizing an objective function with unary and pair-wise terms
    over a discretized domain. This allows the use of techniques originally devel-oped
    for MAP-MRF inference and learning. We explore two ways to set up the objective
    function - by discretizing the Bethe free energy and by learning it  from training
    data. Experimental results show that for certain types of graphs a learned function
    can out-perform the  Bethe approximation. We also establish a link between the
    Bethe free energy and submodular functions.
alternative_title:
- IST Austria Technical Report
author:
- first_name: Filip
  full_name: Korc, Filip
  id: 476A2FD6-F248-11E8-B48F-1D18A9856A87
  last_name: Korc
- first_name: Vladimir
  full_name: Kolmogorov, Vladimir
  id: 3D50B0BA-F248-11E8-B48F-1D18A9856A87
  last_name: Kolmogorov
- first_name: Christoph
  full_name: Lampert, Christoph
  id: 40C20FD2-F248-11E8-B48F-1D18A9856A87
  last_name: Lampert
  orcid: 0000-0001-8622-7887
citation:
  ama: Korc F, Kolmogorov V, Lampert C. <i>Approximating Marginals Using Discrete
    Energy Minimization</i>. IST Austria; 2012. doi:<a href="https://doi.org/10.15479/AT:IST-2012-0003">10.15479/AT:IST-2012-0003</a>
  apa: Korc, F., Kolmogorov, V., &#38; Lampert, C. (2012). <i>Approximating marginals
    using discrete energy minimization</i>. IST Austria. <a href="https://doi.org/10.15479/AT:IST-2012-0003">https://doi.org/10.15479/AT:IST-2012-0003</a>
  chicago: Korc, Filip, Vladimir Kolmogorov, and Christoph Lampert. <i>Approximating
    Marginals Using Discrete Energy Minimization</i>. IST Austria, 2012. <a href="https://doi.org/10.15479/AT:IST-2012-0003">https://doi.org/10.15479/AT:IST-2012-0003</a>.
  ieee: F. Korc, V. Kolmogorov, and C. Lampert, <i>Approximating marginals using discrete
    energy minimization</i>. IST Austria, 2012.
  ista: Korc F, Kolmogorov V, Lampert C. 2012. Approximating marginals using discrete
    energy minimization, IST Austria, 13p.
  mla: Korc, Filip, et al. <i>Approximating Marginals Using Discrete Energy Minimization</i>.
    IST Austria, 2012, doi:<a href="https://doi.org/10.15479/AT:IST-2012-0003">10.15479/AT:IST-2012-0003</a>.
  short: F. Korc, V. Kolmogorov, C. Lampert, Approximating Marginals Using Discrete
    Energy Minimization, IST Austria, 2012.
date_created: 2018-12-12T11:39:06Z
date_published: 2012-07-23T00:00:00Z
date_updated: 2024-10-09T20:54:48Z
day: '23'
ddc:
- '000'
department:
- _id: VlKo
- _id: ChLa
doi: 10.15479/AT:IST-2012-0003
file:
- access_level: open_access
  checksum: 7e0ba85ad123b13223aaf6cdde2d288c
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T11:53:29Z
  date_updated: 2020-07-14T12:46:44Z
  file_id: '5490'
  file_name: IST-2012-0003_IST-2012-0003.pdf
  file_size: 618744
  relation: main_file
file_date_updated: 2020-07-14T12:46:44Z
has_accepted_license: '1'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: '13'
publication_identifier:
  issn:
  - 2664-1690
publication_status: published
publisher: IST Austria
pubrep_id: '36'
related_material:
  record:
  - id: '3124'
    relation: earlier_version
    status: public
status: public
title: Approximating marginals using discrete energy minimization
type: technical_report
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2012'
...
---
_id: '5398'
abstract:
- lang: eng
  text: This document is created as a part of the project “Repository for Research
    Data on IST Austria”. It summarises the actual state of research data at IST Austria,
    based on survey results. It supports the choice of appropriate software, which
    would best fit the requirements of their users, the researchers.
author:
- first_name: Jana
  full_name: Porsche, Jana
  id: 3252EDC2-F248-11E8-B48F-1D18A9856A87
  last_name: Porsche
citation:
  ama: Porsche J. <i>Actual State of Research Data @ ISTAustria</i>. IST Austria;
    2012.
  apa: Porsche, J. (2012). <i>Actual state of research data @ ISTAustria</i>. IST
    Austria.
  chicago: Porsche, Jana. <i>Actual State of Research Data @ ISTAustria</i>. IST Austria,
    2012.
  ieee: J. Porsche, <i>Actual state of research data @ ISTAustria</i>. IST Austria,
    2012.
  ista: Porsche J. 2012. Actual state of research data @ ISTAustria, IST Austria,p.
  mla: Porsche, Jana. <i>Actual State of Research Data @ ISTAustria</i>. IST Austria,
    2012.
  short: J. Porsche, Actual State of Research Data @ ISTAustria, IST Austria, 2012.
date_created: 2018-12-12T11:39:06Z
date_published: 2012-11-12T00:00:00Z
date_updated: 2020-07-14T23:04:49Z
day: '12'
ddc:
- '020'
department:
- _id: E-Lib
file:
- access_level: open_access
  checksum: e0a7c041eea1ca4b70ab6f9ec5177f4e
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T11:53:11Z
  date_updated: 2020-07-14T12:46:44Z
  file_id: '5472'
  file_name: IST-2012-103-v1+1_Actual_state_of_research_data_@_IST_Austria.pdf
  file_size: 238544
  relation: main_file
file_date_updated: 2020-07-14T12:46:44Z
has_accepted_license: '1'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
publication_status: published
publisher: IST Austria
pubrep_id: '103'
status: public
title: Actual state of research data @ ISTAustria
type: report
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2012'
...
---
OA_place: repository
_id: '5745'
abstract:
- lang: eng
  text: Unsatisfiability proofs find many applications in verification. Today, many
    SAT solvers are capable of producing resolution proofs of unsatisfiability. For
    efficiency smaller proofs are preferred over bigger ones. The solvers apply proof
    reduction methods to remove redundant parts of the proofs while and after generating
    the proofs. One method of reducing resolution proofs is redundant resolution reduction,
    i.e., removing repeated pivots in the paths of resolution proofs (aka Pivot recycle).
    The known single pass algorithm only tries to remove redundancies in the parts
    of the proof that are trees. In this paper, we present three modifications to
    improve the algorithm such that the redundancies can be found in the parts of
    the proofs that are DAGs. The first modified algorithm covers greater number of
    redundancies as compared to the known algorithm without incurring any additional
    cost. The second modified algorithm covers even greater number of the redundancies
    but it may have longer run times. Our third modified algorithm is parametrized
    and can trade off between run times and the coverage of the redundancies. We have
    implemented our algorithms in OpenSMT and applied them on unsatisfiability proofs
    of 198 examples from plain MUS track of SAT11 competition. The first and second
    algorithm additionally remove 0.89% and 10.57% of clauses respectively as compared
    to the original algorithm. For certain value of the parameter, the third algorithm
    removes almost as many clauses as the second algorithm but is significantly faster.
acknowledgement: "This work was supported by the ERC Advanced Investigator grant on
  Quantitative\r\nReactive Modeling (QUAREM)."
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Ashutosh
  full_name: Gupta, Ashutosh
  id: 335E5684-F248-11E8-B48F-1D18A9856A87
  last_name: Gupta
citation:
  ama: 'Gupta A. Improved single pass algorithms for resolution proof reduction. In:
    <i>10th International Symposium on Automated Technology for Verification and Analysis</i>.
    Vol 7561. Springer Nature; 2012:107-121. doi:<a href="https://doi.org/10.1007/978-3-642-33386-6_10">10.1007/978-3-642-33386-6_10</a>'
  apa: 'Gupta, A. (2012). Improved single pass algorithms for resolution proof reduction.
    In <i>10th International Symposium on Automated Technology for Verification and
    Analysis</i> (Vol. 7561, pp. 107–121). Thiruvananthapuram, Kerala, India: Springer
    Nature. <a href="https://doi.org/10.1007/978-3-642-33386-6_10">https://doi.org/10.1007/978-3-642-33386-6_10</a>'
  chicago: Gupta, Ashutosh. “Improved Single Pass Algorithms for Resolution Proof
    Reduction.” In <i>10th International Symposium on Automated Technology for Verification
    and Analysis</i>, 7561:107–21. Springer Nature, 2012. <a href="https://doi.org/10.1007/978-3-642-33386-6_10">https://doi.org/10.1007/978-3-642-33386-6_10</a>.
  ieee: A. Gupta, “Improved single pass algorithms for resolution proof reduction,”
    in <i>10th International Symposium on Automated Technology for Verification and
    Analysis</i>, Thiruvananthapuram, Kerala, India, 2012, vol. 7561, pp. 107–121.
  ista: 'Gupta A. 2012. Improved single pass algorithms for resolution proof reduction.
    10th International Symposium on Automated Technology for Verification and Analysis.
    ATVA: Automated Technology for Verification and Analysis, LNCS, vol. 7561, 107–121.'
  mla: Gupta, Ashutosh. “Improved Single Pass Algorithms for Resolution Proof Reduction.”
    <i>10th International Symposium on Automated Technology for Verification and Analysis</i>,
    vol. 7561, Springer Nature, 2012, pp. 107–21, doi:<a href="https://doi.org/10.1007/978-3-642-33386-6_10">10.1007/978-3-642-33386-6_10</a>.
  short: A. Gupta, in:, 10th International Symposium on Automated Technology for Verification
    and Analysis, Springer Nature, 2012, pp. 107–121.
conference:
  end_date: 2012-10-06
  location: Thiruvananthapuram, Kerala, India
  name: 'ATVA: Automated Technology for Verification and Analysis'
  start_date: 2012-10-03
corr_author: '1'
date_created: 2018-12-18T13:01:46Z
date_published: 2012-09-28T00:00:00Z
date_updated: 2025-04-15T07:56:27Z
day: '28'
ddc:
- '005'
department:
- _id: ToHe
doi: 10.1007/978-3-642-33386-6_10
ec_funded: 1
file:
- access_level: open_access
  checksum: 68415837a315de3cc4d120f6019d752c
  content_type: application/pdf
  creator: dernst
  date_created: 2018-12-18T13:07:35Z
  date_updated: 2020-07-14T12:47:10Z
  file_id: '5746'
  file_name: 2012_ATVA_Gupta.pdf
  file_size: 465502
  relation: main_file
file_date_updated: 2020-07-14T12:47:10Z
has_accepted_license: '1'
intvolume: '      7561'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Submitted Version
page: 107-121
project:
- _id: 25EE3708-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '267989'
  name: Quantitative Reactive Modeling
publication: 10th International Symposium on Automated Technology for Verification
  and Analysis
publication_identifier:
  eisbn:
  - '9783642333866'
  eissn:
  - 1611-3349
  isbn:
  - '9783642333859'
  issn:
  - 0302-9743
publication_status: published
publisher: Springer Nature
pubrep_id: '180'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Improved single pass algorithms for resolution proof reduction
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 7561
year: '2012'
...
---
_id: '5839'
abstract:
- lang: eng
  text: "Canny's edge detection algorithm is a classical and robust method for edge
    detection in gray-scale images. The two \r\nsignificant features of this method
    are introduction of NMS (Non-Maximum Suppression) and double thresholding of \r\nthe
    \ gradient  image.  Due  to  poor  illumination,  the  region  boundaries  in
    \ an  image  may  become  vague,  creating  \r\nuncertainties  in  the  gradient
    \ image.  In  this  paper,  we  have  proposed  an  algorithm  based  on  the
    \ concept  of  type-2  fuzzy  sets  to  handle  uncertainties  that  automatically
    \ selects  the  threshold  values  needed  to  segment  the  gradient image using
    classical Canny’s edge detection algorithm. The results show that our algorithm
    works significantly well on different benchmark images as well as medical images
    (hand radiography images). "
author:
- first_name: Ranita
  full_name: Biswas, Ranita
  id: 3C2B033E-F248-11E8-B48F-1D18A9856A87
  last_name: Biswas
  orcid: 0000-0002-5372-7890
- first_name: Jaya
  full_name: Sil, Jaya
  last_name: Sil
citation:
  ama: Biswas R, Sil J. An Improved Canny Edge Detection Algorithm Based on Type-2
    Fuzzy Sets. <i>Procedia Technology</i>. 2012;4:820-824. doi:<a href="https://doi.org/10.1016/j.protcy.2012.05.134">10.1016/j.protcy.2012.05.134</a>
  apa: Biswas, R., &#38; Sil, J. (2012). An Improved Canny Edge Detection Algorithm
    Based on Type-2 Fuzzy Sets. <i>Procedia Technology</i>. Elsevier. <a href="https://doi.org/10.1016/j.protcy.2012.05.134">https://doi.org/10.1016/j.protcy.2012.05.134</a>
  chicago: Biswas, Ranita, and Jaya Sil. “An Improved Canny Edge Detection Algorithm
    Based on Type-2 Fuzzy Sets.” <i>Procedia Technology</i>. Elsevier, 2012. <a href="https://doi.org/10.1016/j.protcy.2012.05.134">https://doi.org/10.1016/j.protcy.2012.05.134</a>.
  ieee: R. Biswas and J. Sil, “An Improved Canny Edge Detection Algorithm Based on
    Type-2 Fuzzy Sets,” <i>Procedia Technology</i>, vol. 4. Elsevier, pp. 820–824,
    2012.
  ista: Biswas R, Sil J. 2012. An Improved Canny Edge Detection Algorithm Based on
    Type-2 Fuzzy Sets. Procedia Technology. 4, 820–824.
  mla: Biswas, Ranita, and Jaya Sil. “An Improved Canny Edge Detection Algorithm Based
    on Type-2 Fuzzy Sets.” <i>Procedia Technology</i>, vol. 4, Elsevier, 2012, pp.
    820–24, doi:<a href="https://doi.org/10.1016/j.protcy.2012.05.134">10.1016/j.protcy.2012.05.134</a>.
  short: R. Biswas, J. Sil, Procedia Technology 4 (2012) 820–824.
date_created: 2019-01-17T11:54:21Z
date_published: 2012-05-01T00:00:00Z
date_updated: 2021-01-12T08:03:43Z
day: '01'
ddc:
- '000'
doi: 10.1016/j.protcy.2012.05.134
extern: '1'
file:
- access_level: open_access
  checksum: ba0185986b151d8c11201f48cd505ceb
  content_type: application/pdf
  creator: dernst
  date_created: 2019-01-21T07:28:06Z
  date_updated: 2020-07-14T12:47:12Z
  file_id: '5863'
  file_name: 2012_Procedia_Biswas.pdf
  file_size: 305426
  relation: main_file
file_date_updated: 2020-07-14T12:47:12Z
has_accepted_license: '1'
intvolume: '         4'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
page: 820-824
publication: Procedia Technology
publication_identifier:
  issn:
  - 2212-0173
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: An Improved Canny Edge Detection Algorithm Based on Type-2 Fuzzy Sets
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 4
year: '2012'
...
---
_id: '596'
abstract:
- lang: eng
  text: The human Mediator complex controls RNA polymerase II (pol II) function in
    ways that remain incompletely understood. Activator-Mediator binding alters Mediator
    structure, and these activator-induced structural shifts appear to play key roles
    in regulating transcription. A recent cryo-electron microscopy (EM) analysis revealed
    that pol II adopted a stable orientation within a Mediator-pol II-TFIIF assembly
    in which Mediator was bound to the activation domain of viral protein 16 (VP16).
    Whereas TFIIF was shown to be important for orienting pol II within this assembly,
    the potential role of the activator was not assessed. To determine how activator
    binding might affect pol II orientation, we isolated human Mediator-pol II-TFIIF
    complexes in which Mediator was not bound to an activator. Cryo-EM analysis of
    this assembly, coupled with pol II crystal structure docking, revealed that pol
    II binds Mediator at the same general location; however, in contrast to VP16-bound
    Mediator, pol II does not appear to stably orient in the absence of an activator.
    Variability in pol II orientation might be important mechanistically, perhaps
    to enable sense and antisense transcription at human promoters. Because Mediator
    interacts extensively with pol II, these results suggest that Mediator structural
    shifts induced by activator binding help stably orient pol II prior to transcription
    initiation.
article_processing_charge: No
author:
- first_name: Carrie A
  full_name: Bernecky, Carrie A
  id: 2CB9DFE2-F248-11E8-B48F-1D18A9856A87
  last_name: Bernecky
  orcid: 0000-0003-0893-7036
- first_name: Dylan
  full_name: Taatjes, Dylan
  last_name: Taatjes
citation:
  ama: Bernecky C, Taatjes D. Activator-mediator binding stabilizes RNA polymerase
    II orientation within the human mediator-RNA polymerase II-TFIIF assembly. <i>Journal
    of Molecular Biology</i>. 2012;417(5):387-394. doi:<a href="https://doi.org/10.1016/j.jmb.2012.02.014">10.1016/j.jmb.2012.02.014</a>
  apa: Bernecky, C., &#38; Taatjes, D. (2012). Activator-mediator binding stabilizes
    RNA polymerase II orientation within the human mediator-RNA polymerase II-TFIIF
    assembly. <i>Journal of Molecular Biology</i>. Elsevier. <a href="https://doi.org/10.1016/j.jmb.2012.02.014">https://doi.org/10.1016/j.jmb.2012.02.014</a>
  chicago: Bernecky, Carrie, and Dylan Taatjes. “Activator-Mediator Binding Stabilizes
    RNA Polymerase II Orientation within the Human Mediator-RNA Polymerase II-TFIIF
    Assembly.” <i>Journal of Molecular Biology</i>. Elsevier, 2012. <a href="https://doi.org/10.1016/j.jmb.2012.02.014">https://doi.org/10.1016/j.jmb.2012.02.014</a>.
  ieee: C. Bernecky and D. Taatjes, “Activator-mediator binding stabilizes RNA polymerase
    II orientation within the human mediator-RNA polymerase II-TFIIF assembly,” <i>Journal
    of Molecular Biology</i>, vol. 417, no. 5. Elsevier, pp. 387–394, 2012.
  ista: Bernecky C, Taatjes D. 2012. Activator-mediator binding stabilizes RNA polymerase
    II orientation within the human mediator-RNA polymerase II-TFIIF assembly. Journal
    of Molecular Biology. 417(5), 387–394.
  mla: Bernecky, Carrie, and Dylan Taatjes. “Activator-Mediator Binding Stabilizes
    RNA Polymerase II Orientation within the Human Mediator-RNA Polymerase II-TFIIF
    Assembly.” <i>Journal of Molecular Biology</i>, vol. 417, no. 5, Elsevier, 2012,
    pp. 387–94, doi:<a href="https://doi.org/10.1016/j.jmb.2012.02.014">10.1016/j.jmb.2012.02.014</a>.
  short: C. Bernecky, D. Taatjes, Journal of Molecular Biology 417 (2012) 387–394.
date_created: 2018-12-11T11:47:24Z
date_published: 2012-04-13T00:00:00Z
date_updated: 2021-01-12T08:05:21Z
day: '13'
doi: 10.1016/j.jmb.2012.02.014
extern: '1'
intvolume: '       417'
issue: '5'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582759/
month: '04'
oa: 1
oa_version: None
page: 387 - 394
publication: Journal of Molecular Biology
publication_status: published
publisher: Elsevier
publist_id: '7208'
status: public
title: Activator-mediator binding stabilizes RNA polymerase II orientation within
  the human mediator-RNA polymerase II-TFIIF assembly
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 417
year: '2012'
...
---
_id: '6136'
abstract:
- lang: eng
  text: Tonic receptors convey stimulus duration and intensity and are implicated
    in homeostatic control. However, how tonic homeostatic signals are generated and
    how they reconfigure neural circuits and modify animal behavior is poorly understood.
    Here we show that Caenorhabditis elegans O2-sensing neurons are tonic receptors
    that continuously signal ambient [O2] to set the animal's behavioral state. Sustained
    signaling relied on a Ca2+ relay involving L-type voltage-gated Ca2+ channels,
    the ryanodine and the inositol-1,4,5-trisphosphate receptors. Tonic activity evoked
    continuous neuropeptide release, which helps elicit the enduring behavioral state
    associated with high [O2]. Sustained O2 receptor signaling was propagated to downstream
    neural circuits, including the hub interneuron RMG. O2 receptors evoked similar
    locomotory states at particular O2 concentrations, regardless of previous d[O2]/dt.
    However, a phasic component of the URX receptors' response to high d[O2]/dt, as
    well as tonic-to-phasic transformations in downstream interneurons, enabled transient
    reorientation movements shaped by d[O2]/dt. Our results highlight how tonic homeostatic
    signals can generate both transient and enduring behavioral change.
author:
- first_name: Karl Emanuel
  full_name: Busch, Karl Emanuel
  last_name: Busch
- first_name: Patrick
  full_name: Laurent, Patrick
  last_name: Laurent
- first_name: Zoltan
  full_name: Soltesz, Zoltan
  last_name: Soltesz
- first_name: Robin Joseph
  full_name: Murphy, Robin Joseph
  last_name: Murphy
- first_name: Olivier
  full_name: Faivre, Olivier
  last_name: Faivre
- first_name: Berthold
  full_name: Hedwig, Berthold
  last_name: Hedwig
- first_name: Martin
  full_name: Thomas, Martin
  last_name: Thomas
- first_name: Heather L
  full_name: Smith, Heather L
  last_name: Smith
- first_name: Mario
  full_name: de Bono, Mario
  id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87
  last_name: de Bono
  orcid: 0000-0001-8347-0443
citation:
  ama: Busch KE, Laurent P, Soltesz Z, et al. Tonic signaling from O2 sensors sets
    neural circuit activity and behavioral state. <i>Nature Neuroscience</i>. 2012;15(4):581-591.
    doi:<a href="https://doi.org/10.1038/nn.3061">10.1038/nn.3061</a>
  apa: Busch, K. E., Laurent, P., Soltesz, Z., Murphy, R. J., Faivre, O., Hedwig,
    B., … de Bono, M. (2012). Tonic signaling from O2 sensors sets neural circuit
    activity and behavioral state. <i>Nature Neuroscience</i>. Springer Nature. <a
    href="https://doi.org/10.1038/nn.3061">https://doi.org/10.1038/nn.3061</a>
  chicago: Busch, Karl Emanuel, Patrick Laurent, Zoltan Soltesz, Robin Joseph Murphy,
    Olivier Faivre, Berthold Hedwig, Martin Thomas, Heather L Smith, and Mario de
    Bono. “Tonic Signaling from O2 Sensors Sets Neural Circuit Activity and Behavioral
    State.” <i>Nature Neuroscience</i>. Springer Nature, 2012. <a href="https://doi.org/10.1038/nn.3061">https://doi.org/10.1038/nn.3061</a>.
  ieee: K. E. Busch <i>et al.</i>, “Tonic signaling from O2 sensors sets neural circuit
    activity and behavioral state,” <i>Nature Neuroscience</i>, vol. 15, no. 4. Springer
    Nature, pp. 581–591, 2012.
  ista: Busch KE, Laurent P, Soltesz Z, Murphy RJ, Faivre O, Hedwig B, Thomas M, Smith
    HL, de Bono M. 2012. Tonic signaling from O2 sensors sets neural circuit activity
    and behavioral state. Nature Neuroscience. 15(4), 581–591.
  mla: Busch, Karl Emanuel, et al. “Tonic Signaling from O2 Sensors Sets Neural Circuit
    Activity and Behavioral State.” <i>Nature Neuroscience</i>, vol. 15, no. 4, Springer
    Nature, 2012, pp. 581–91, doi:<a href="https://doi.org/10.1038/nn.3061">10.1038/nn.3061</a>.
  short: K.E. Busch, P. Laurent, Z. Soltesz, R.J. Murphy, O. Faivre, B. Hedwig, M.
    Thomas, H.L. Smith, M. de Bono, Nature Neuroscience 15 (2012) 581–591.
date_created: 2019-03-20T14:23:30Z
date_published: 2012-03-04T00:00:00Z
date_updated: 2021-01-12T08:06:17Z
day: '04'
doi: 10.1038/nn.3061
extern: '1'
external_id:
  pmid:
  - '22388961'
intvolume: '        15'
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564487/
month: '03'
oa: 1
oa_version: Submitted Version
page: 581-591
pmid: 1
publication: Nature Neuroscience
publication_identifier:
  issn:
  - 1097-6256
  - 1546-1726
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Tonic signaling from O2 sensors sets neural circuit activity and behavioral
  state
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 15
year: '2012'
...
---
_id: '1987'
abstract:
- lang: eng
  text: |
    In the living cell, proteins are able to organize space much larger than their dimensions. In return, changes of intracellular space can influence biochemical reactions, allowing cells to sense their size and shape. Despite the possibility to reconstitute protein self-organization with only a few purified components, we still lack knowledge of how geometrical boundaries affect spatiotemporal protein patterns. Following a minimal systems approach, we used purified proteins and photolithographically patterned membranes to study the influence of spatial confinement on the self-organization of the Min system, a spatial regulator of bacterial cytokinesis, in vitro. We found that the emerging protein pattern responds even to the lateral, two-dimensional geometry of the membrane such that, as in the three-dimensional cell, Min protein waves travel along the longest axis of the membrane patch. This shows that for spatial sensing the Min system does not need to be enclosed in a three-dimensional compartment. Using a computational model we quantitatively analyzed our experimental findings and identified persistent binding of MinE to the membrane as requirement for the Min system to sense geometry. Our results give insight into the interplay between geometrical confinement and biochemical patterns emerging from a nonlinear reaction-diffusion system.
acknowledgement: 'This work was supported by the Max-Planck-Society (P.S. and M.L.)
  and by the German Research Foundation as part of the Research Training Group “Nano-
  and Biotechnologies for Electronic Device Packaging” (GRK 1401) (J.S.) and by the
  Leibniz-Award (P.S.). '
author:
- first_name: Jakob
  full_name: Schweizer, Jakob
  last_name: Schweizer
- first_name: Martin
  full_name: Martin Loose
  id: 462D4284-F248-11E8-B48F-1D18A9856A87
  last_name: Loose
  orcid: 0000-0001-7309-9724
- first_name: Mike
  full_name: 'Bonny, Mike '
  last_name: Bonny
- first_name: Karsten
  full_name: Kruse, Karsten
  last_name: Kruse
- first_name: Ingolf
  full_name: Mönch, Ingolf
  last_name: Mönch
- first_name: Petra
  full_name: 'Schwille, Petra '
  last_name: Schwille
citation:
  ama: Schweizer J, Loose M, Bonny M, Kruse K, Mönch I, Schwille P. Geometry sensing
    by self-organized protein patterns. <i>PNAS</i>. 2012;109(38):15283-15288. doi:<a
    href="https://doi.org/10.1073/pnas.1206953109">10.1073/pnas.1206953109</a>
  apa: Schweizer, J., Loose, M., Bonny, M., Kruse, K., Mönch, I., &#38; Schwille,
    P. (2012). Geometry sensing by self-organized protein patterns. <i>PNAS</i>. National
    Academy of Sciences. <a href="https://doi.org/10.1073/pnas.1206953109">https://doi.org/10.1073/pnas.1206953109</a>
  chicago: Schweizer, Jakob, Martin Loose, Mike Bonny, Karsten Kruse, Ingolf Mönch,
    and Petra Schwille. “Geometry Sensing by Self-Organized Protein Patterns.” <i>PNAS</i>.
    National Academy of Sciences, 2012. <a href="https://doi.org/10.1073/pnas.1206953109">https://doi.org/10.1073/pnas.1206953109</a>.
  ieee: J. Schweizer, M. Loose, M. Bonny, K. Kruse, I. Mönch, and P. Schwille, “Geometry
    sensing by self-organized protein patterns,” <i>PNAS</i>, vol. 109, no. 38. National
    Academy of Sciences, pp. 15283–15288, 2012.
  ista: Schweizer J, Loose M, Bonny M, Kruse K, Mönch I, Schwille P. 2012. Geometry
    sensing by self-organized protein patterns. PNAS. 109(38), 15283–15288.
  mla: Schweizer, Jakob, et al. “Geometry Sensing by Self-Organized Protein Patterns.”
    <i>PNAS</i>, vol. 109, no. 38, National Academy of Sciences, 2012, pp. 15283–88,
    doi:<a href="https://doi.org/10.1073/pnas.1206953109">10.1073/pnas.1206953109</a>.
  short: J. Schweizer, M. Loose, M. Bonny, K. Kruse, I. Mönch, P. Schwille, PNAS 109
    (2012) 15283–15288.
date_created: 2018-12-11T11:55:04Z
date_published: 2012-09-18T00:00:00Z
date_updated: 2021-01-12T06:54:31Z
day: '18'
doi: 10.1073/pnas.1206953109
extern: 1
intvolume: '       109'
issue: '38'
month: '09'
page: 15283 - 15288
publication: PNAS
publication_status: published
publisher: National Academy of Sciences
publist_id: '5096'
quality_controlled: 0
status: public
title: Geometry sensing by self-organized protein patterns
type: journal_article
volume: 109
year: '2012'
...
---
_id: '2073'
abstract:
- lang: eng
  text: 'Background: Drosophila albomicans is a unique model organism for studying
    both sex chromosome and B chromosome evolution. A pair of its autosomes comprising
    roughly 40% of the whole genome has fused to the ancient X and Y chromosomes only
    about 0.12 million years ago, thereby creating the youngest and most gene-rich
    neo-sex system reported to date. This species also possesses recently derived
    B chromosomes that show non-Mendelian inheritance and significantly influence
    fertility.Methods: We sequenced male flies with B chromosomes at 124.5-fold genome
    coverage using next-generation sequencing. To characterize neo-Y specific changes
    and B chromosome sequences, we also sequenced inbred female flies derived from
    the same strain but without B''s at 28.5-fold.Results: We assembled a female genome
    and placed 53% of the sequence and 85% of the annotated proteins into specific
    chromosomes, by comparison with the 12 Drosophila genomes. Despite its very recent
    origin, the non-recombining neo-Y chromosome shows various signs of degeneration,
    including a significant enrichment of non-functional genes compared to the neo-X,
    and an excess of tandem duplications relative to other chromosomes. We also characterized
    a B-chromosome linked scaffold that contains an actively transcribed unit and
    shows sequence similarity to the subcentromeric regions of both the ancient X
    and the neo-X chromosome.Conclusions: Our results provide novel insights into
    the very early stages of sex chromosome evolution and B chromosome origination,
    and suggest an unprecedented connection between the births of these two systems
    in D. albomicans.'
author:
- first_name: Qi
  full_name: Zhou, Qi
  last_name: Zhou
- first_name: Hongmei
  full_name: Zhu, Hongmei
  last_name: Zhu
- first_name: Quanfei
  full_name: Huang, Quanfei
  last_name: Huang
- first_name: Li
  full_name: Zhao, Li
  last_name: Zhao
- first_name: Guo
  full_name: Zhang, Guo J
  last_name: Zhang
- first_name: Scott
  full_name: Roy, Scott W
  last_name: Roy
- first_name: Beatriz
  full_name: Beatriz Vicoso
  id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
  last_name: Vicoso
  orcid: 0000-0002-4579-8306
- first_name: Zhaolin
  full_name: Xuan, Zhaolin
  last_name: Xuan
- first_name: Jue
  full_name: Ruan, Jue
  last_name: Ruan
- first_name: Yue
  full_name: Zhang, Yue
  last_name: Zhang
- first_name: Ruoping
  full_name: Zhao, Ruoping
  last_name: Zhao
- first_name: Chen
  full_name: Ye, Chen
  last_name: Ye
- first_name: Xiuqing
  full_name: Zhang, Xiuqing
  last_name: Zhang
- first_name: Jùn
  full_name: Wang, Jùn
  last_name: Wang
- first_name: Wen
  full_name: Wang, Wen
  last_name: Wang
- first_name: Doris
  full_name: Bachtrog, Doris
  last_name: Bachtrog
citation:
  ama: Zhou Q, Zhu H, Huang Q, et al. Deciphering neo-sex and B chromosome evolution
    by the draft genome of Drosophila albomicans. <i>BMC Genomics</i>. 2012;13(1).
    doi:<a href="https://doi.org/10.1186/1471-2164-13-109">10.1186/1471-2164-13-109</a>
  apa: Zhou, Q., Zhu, H., Huang, Q., Zhao, L., Zhang, G., Roy, S., … Bachtrog, D.
    (2012). Deciphering neo-sex and B chromosome evolution by the draft genome of
    Drosophila albomicans. <i>BMC Genomics</i>. BioMed Central. <a href="https://doi.org/10.1186/1471-2164-13-109">https://doi.org/10.1186/1471-2164-13-109</a>
  chicago: Zhou, Qi, Hongmei Zhu, Quanfei Huang, Li Zhao, Guo Zhang, Scott Roy, Beatriz
    Vicoso, et al. “Deciphering Neo-Sex and B Chromosome Evolution by the Draft Genome
    of Drosophila Albomicans.” <i>BMC Genomics</i>. BioMed Central, 2012. <a href="https://doi.org/10.1186/1471-2164-13-109">https://doi.org/10.1186/1471-2164-13-109</a>.
  ieee: Q. Zhou <i>et al.</i>, “Deciphering neo-sex and B chromosome evolution by
    the draft genome of Drosophila albomicans,” <i>BMC Genomics</i>, vol. 13, no.
    1. BioMed Central, 2012.
  ista: Zhou Q, Zhu H, Huang Q, Zhao L, Zhang G, Roy S, Vicoso B, Xuan Z, Ruan J,
    Zhang Y, Zhao R, Ye C, Zhang X, Wang J, Wang W, Bachtrog D. 2012. Deciphering
    neo-sex and B chromosome evolution by the draft genome of Drosophila albomicans.
    BMC Genomics. 13(1).
  mla: Zhou, Qi, et al. “Deciphering Neo-Sex and B Chromosome Evolution by the Draft
    Genome of Drosophila Albomicans.” <i>BMC Genomics</i>, vol. 13, no. 1, BioMed
    Central, 2012, doi:<a href="https://doi.org/10.1186/1471-2164-13-109">10.1186/1471-2164-13-109</a>.
  short: Q. Zhou, H. Zhu, Q. Huang, L. Zhao, G. Zhang, S. Roy, B. Vicoso, Z. Xuan,
    J. Ruan, Y. Zhang, R. Zhao, C. Ye, X. Zhang, J. Wang, W. Wang, D. Bachtrog, BMC
    Genomics 13 (2012).
date_created: 2018-12-11T11:55:33Z
date_published: 2012-03-22T00:00:00Z
date_updated: 2021-01-12T06:55:08Z
day: '22'
doi: 10.1186/1471-2164-13-109
extern: 1
intvolume: '        13'
issue: '1'
month: '03'
publication: BMC Genomics
publication_status: published
publisher: BioMed Central
publist_id: '4965'
quality_controlled: 0
status: public
title: Deciphering neo-sex and B chromosome evolution by the draft genome of Drosophila
  albomicans
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
volume: 13
year: '2012'
...
---
_id: '2079'
abstract:
- lang: eng
  text: We introduce an algorithm and representation for fabricating 3D shape abstractions
    using mutually intersecting planar cut-outs. The planes have prefabricated slits
    at their intersections and are assembled by sliding them together. Often such
    abstractions are used as a sculptural art form or in architecture and are colloquially
    called ‘cardboard sculptures’. Based on an analysis of construction rules, we
    propose an extended binary space partitioning tree as an efficient representation
    of such cardboard models which allows us to quickly evaluate the feasibility of
    newly added planar elements. The complexity of insertion order quickly increases
    with the number of planar elements and manual analysis becomes intractable. We
    provide tools for generating cardboard sculptures with guaranteed constructibility.
    In combination with a simple optimization and sampling strategy for new elements,
    planar shape abstraction models can be designed by iteratively adding elements.
    As an output, we obtain a fabrication plan that can be printed or sent to a laser
    cutter. We demonstrate the complete process by designing and fabricating cardboard
    models of various well-known 3D shapes.
author:
- first_name: Kristian
  full_name: Hildebrand, Kristian
  last_name: Hildebrand
- first_name: Bernd
  full_name: Bernd Bickel
  id: 49876194-F248-11E8-B48F-1D18A9856A87
  last_name: Bickel
  orcid: 0000-0001-6511-9385
- first_name: Marc
  full_name: Alexa, Marc
  last_name: Alexa
citation:
  ama: 'Hildebrand K, Bickel B, Alexa M. crdbrd: Shape fabrication by sliding planar
    slices. <i>Computer Graphics Forum</i>. 2012;31(2pt3):583-592. doi:<a href="https://doi.org/10.1111/j.1467-8659.2012.03037.x">10.1111/j.1467-8659.2012.03037.x</a>'
  apa: 'Hildebrand, K., Bickel, B., &#38; Alexa, M. (2012). crdbrd: Shape fabrication
    by sliding planar slices. <i>Computer Graphics Forum</i>. Wiley-Blackwell. <a
    href="https://doi.org/10.1111/j.1467-8659.2012.03037.x">https://doi.org/10.1111/j.1467-8659.2012.03037.x</a>'
  chicago: 'Hildebrand, Kristian, Bernd Bickel, and Marc Alexa. “Crdbrd: Shape Fabrication
    by Sliding Planar Slices.” <i>Computer Graphics Forum</i>. Wiley-Blackwell, 2012.
    <a href="https://doi.org/10.1111/j.1467-8659.2012.03037.x">https://doi.org/10.1111/j.1467-8659.2012.03037.x</a>.'
  ieee: 'K. Hildebrand, B. Bickel, and M. Alexa, “crdbrd: Shape fabrication by sliding
    planar slices,” <i>Computer Graphics Forum</i>, vol. 31, no. 2pt3. Wiley-Blackwell,
    pp. 583–592, 2012.'
  ista: 'Hildebrand K, Bickel B, Alexa M. 2012. crdbrd: Shape fabrication by sliding
    planar slices. Computer Graphics Forum. 31(2pt3), 583–592.'
  mla: 'Hildebrand, Kristian, et al. “Crdbrd: Shape Fabrication by Sliding Planar
    Slices.” <i>Computer Graphics Forum</i>, vol. 31, no. 2pt3, Wiley-Blackwell, 2012,
    pp. 583–92, doi:<a href="https://doi.org/10.1111/j.1467-8659.2012.03037.x">10.1111/j.1467-8659.2012.03037.x</a>.'
  short: K. Hildebrand, B. Bickel, M. Alexa, Computer Graphics Forum 31 (2012) 583–592.
date_created: 2018-12-11T11:55:35Z
date_published: 2012-05-01T00:00:00Z
date_updated: 2021-01-12T06:55:10Z
day: '01'
doi: 10.1111/j.1467-8659.2012.03037.x
extern: 1
intvolume: '        31'
issue: 2pt3
month: '05'
page: 583 - 592
publication: Computer Graphics Forum
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4959'
quality_controlled: 0
status: public
title: 'crdbrd: Shape fabrication by sliding planar slices'
type: journal_article
volume: 31
year: '2012'
...
---
_id: '10387'
abstract:
- lang: eng
  text: We report numerical simulations of membrane tubulation driven by large colloidal
    particles. Using Monte Carlo simulations we study how the process depends on particle
    size and binding strength, and present accurate free energy calculations to sort
    out how tube formation compares with the competing budding process. We find that
    tube formation is a result of the collective behavior of the particles adhering
    on the surface, and it occurs for binding strengths that are smaller than those
    required for budding. We also find that long linear aggregates of particles forming
    on the membrane surface act as nucleation seeds for tubulation by lowering the
    free energy barrier associated to the process.
article_number: '188101'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Anđela
  full_name: Šarić, Anđela
  id: bf63d406-f056-11eb-b41d-f263a6566d8b
  last_name: Šarić
  orcid: 0000-0002-7854-2139
- first_name: Angelo
  full_name: Cacciuto, Angelo
  last_name: Cacciuto
citation:
  ama: Šarić A, Cacciuto A. Mechanism of membrane tube formation induced by adhesive
    nanocomponents. <i>Physical Review Letters</i>. 2012;109(18). doi:<a href="https://doi.org/10.1103/physrevlett.109.188101">10.1103/physrevlett.109.188101</a>
  apa: Šarić, A., &#38; Cacciuto, A. (2012). Mechanism of membrane tube formation
    induced by adhesive nanocomponents. <i>Physical Review Letters</i>. American Physical
    Society. <a href="https://doi.org/10.1103/physrevlett.109.188101">https://doi.org/10.1103/physrevlett.109.188101</a>
  chicago: Šarić, Anđela, and Angelo Cacciuto. “Mechanism of Membrane Tube Formation
    Induced by Adhesive Nanocomponents.” <i>Physical Review Letters</i>. American
    Physical Society, 2012. <a href="https://doi.org/10.1103/physrevlett.109.188101">https://doi.org/10.1103/physrevlett.109.188101</a>.
  ieee: A. Šarić and A. Cacciuto, “Mechanism of membrane tube formation induced by
    adhesive nanocomponents,” <i>Physical Review Letters</i>, vol. 109, no. 18. American
    Physical Society, 2012.
  ista: Šarić A, Cacciuto A. 2012. Mechanism of membrane tube formation induced by
    adhesive nanocomponents. Physical Review Letters. 109(18), 188101.
  mla: Šarić, Anđela, and Angelo Cacciuto. “Mechanism of Membrane Tube Formation Induced
    by Adhesive Nanocomponents.” <i>Physical Review Letters</i>, vol. 109, no. 18,
    188101, American Physical Society, 2012, doi:<a href="https://doi.org/10.1103/physrevlett.109.188101">10.1103/physrevlett.109.188101</a>.
  short: A. Šarić, A. Cacciuto, Physical Review Letters 109 (2012).
date_created: 2021-11-29T14:08:00Z
date_published: 2012-10-31T00:00:00Z
date_updated: 2021-11-29T14:29:25Z
day: '31'
doi: 10.1103/physrevlett.109.188101
extern: '1'
external_id:
  arxiv:
  - '1206.3528'
  pmid:
  - '23215334'
intvolume: '       109'
issue: '18'
keyword:
- general physics and astronomy
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1206.3528
month: '10'
oa: 1
oa_version: Preprint
pmid: 1
publication: Physical Review Letters
publication_identifier:
  eissn:
  - 1079-7114
  issn:
  - 0031-9007
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mechanism of membrane tube formation induced by adhesive nanocomponents
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 109
year: '2012'
...
---
_id: '10388'
abstract:
- lang: eng
  text: Using computer simulations, we show that lipid membranes can mediate linear
    aggregation of spherical nanoparticles binding to it for a wide range of biologically
    relevant bending rigidities. This result is in net contrast with the isotropic
    aggregation of nanoparticles on fluid interfaces or the expected clustering of
    isotropic insertions in biological membranes. We present a phase diagram indicating
    where linear aggregation is expected and compute explicitly the free-energy barriers
    associated with linear and isotropic aggregation. Finally, we provide simple scaling
    arguments to explain this phenomenology.
acknowledgement: "This work was supported by the National Science Foundation under
  Career Grant No. DMR-0846426.\r\n"
article_number: '118101'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Anđela
  full_name: Šarić, Anđela
  id: bf63d406-f056-11eb-b41d-f263a6566d8b
  last_name: Šarić
  orcid: 0000-0002-7854-2139
- first_name: Angelo
  full_name: Cacciuto, Angelo
  last_name: Cacciuto
citation:
  ama: Šarić A, Cacciuto A. Fluid membranes can drive linear aggregation of adsorbed
    spherical nanoparticles. <i>Physical Review Letters</i>. 2012;108(11). doi:<a
    href="https://doi.org/10.1103/physrevlett.108.118101">10.1103/physrevlett.108.118101</a>
  apa: Šarić, A., &#38; Cacciuto, A. (2012). Fluid membranes can drive linear aggregation
    of adsorbed spherical nanoparticles. <i>Physical Review Letters</i>. American
    Physical Society. <a href="https://doi.org/10.1103/physrevlett.108.118101">https://doi.org/10.1103/physrevlett.108.118101</a>
  chicago: Šarić, Anđela, and Angelo Cacciuto. “Fluid Membranes Can Drive Linear Aggregation
    of Adsorbed Spherical Nanoparticles.” <i>Physical Review Letters</i>. American
    Physical Society, 2012. <a href="https://doi.org/10.1103/physrevlett.108.118101">https://doi.org/10.1103/physrevlett.108.118101</a>.
  ieee: A. Šarić and A. Cacciuto, “Fluid membranes can drive linear aggregation of
    adsorbed spherical nanoparticles,” <i>Physical Review Letters</i>, vol. 108, no.
    11. American Physical Society, 2012.
  ista: Šarić A, Cacciuto A. 2012. Fluid membranes can drive linear aggregation of
    adsorbed spherical nanoparticles. Physical Review Letters. 108(11), 118101.
  mla: Šarić, Anđela, and Angelo Cacciuto. “Fluid Membranes Can Drive Linear Aggregation
    of Adsorbed Spherical Nanoparticles.” <i>Physical Review Letters</i>, vol. 108,
    no. 11, 118101, American Physical Society, 2012, doi:<a href="https://doi.org/10.1103/physrevlett.108.118101">10.1103/physrevlett.108.118101</a>.
  short: A. Šarić, A. Cacciuto, Physical Review Letters 108 (2012).
date_created: 2021-11-29T14:30:05Z
date_published: 2012-03-14T00:00:00Z
date_updated: 2021-11-29T15:12:13Z
day: '14'
doi: 10.1103/physrevlett.108.118101
extern: '1'
external_id:
  arxiv:
  - '1201.0036'
  pmid:
  - '22540513'
intvolume: '       108'
issue: '11'
keyword:
- general physics and astronomy
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1201.0036
month: '03'
oa: 1
oa_version: Preprint
pmid: 1
publication: Physical Review Letters
publication_identifier:
  eissn:
  - 1079-7114
  issn:
  - 0031-9007
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Fluid membranes can drive linear aggregation of adsorbed spherical nanoparticles
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 108
year: '2012'
...
