---
_id: '2439'
abstract:
- lang: eng
text: A Monte Carlo approximation algorithm for the Tukey depth problem in high
dimensions is introduced. The algorithm is a generalization of an algorithm presented
by Rousseeuw and Struyf (1998) . The performance of this algorithm is studied
both analytically and experimentally.
author:
- first_name: Dan
full_name: Chen, Dan
last_name: Chen
- first_name: Pat
full_name: Morin, Pat
last_name: Morin
- first_name: Uli
full_name: Uli Wagner
id: 36690CA2-F248-11E8-B48F-1D18A9856A87
last_name: Wagner
orcid: 0000-0002-1494-0568
citation:
ama: 'Chen D, Morin P, Wagner U. Absolute approximation of Tukey depth: Theory and
experiments. Computational Geometry: Theory and Applications. 2012;46(5):566-573.
doi:10.1016/j.comgeo.2012.03.001'
apa: 'Chen, D., Morin, P., & Wagner, U. (2012). Absolute approximation of Tukey
depth: Theory and experiments. Computational Geometry: Theory and Applications.
Elsevier. https://doi.org/10.1016/j.comgeo.2012.03.001'
chicago: 'Chen, Dan, Pat Morin, and Uli Wagner. “Absolute Approximation of Tukey
Depth: Theory and Experiments.” Computational Geometry: Theory and Applications.
Elsevier, 2012. https://doi.org/10.1016/j.comgeo.2012.03.001.'
ieee: 'D. Chen, P. Morin, and U. Wagner, “Absolute approximation of Tukey depth:
Theory and experiments,” Computational Geometry: Theory and Applications,
vol. 46, no. 5. Elsevier, pp. 566–573, 2012.'
ista: 'Chen D, Morin P, Wagner U. 2012. Absolute approximation of Tukey depth: Theory
and experiments. Computational Geometry: Theory and Applications. 46(5), 566–573.'
mla: 'Chen, Dan, et al. “Absolute Approximation of Tukey Depth: Theory and Experiments.”
Computational Geometry: Theory and Applications, vol. 46, no. 5, Elsevier,
2012, pp. 566–73, doi:10.1016/j.comgeo.2012.03.001.'
short: 'D. Chen, P. Morin, U. Wagner, Computational Geometry: Theory and Applications
46 (2012) 566–573.'
date_created: 2018-12-11T11:57:40Z
date_published: 2012-07-01T00:00:00Z
date_updated: 2021-01-12T06:57:29Z
day: '01'
doi: 10.1016/j.comgeo.2012.03.001
extern: 1
intvolume: ' 46'
issue: '5'
month: '07'
page: 566 - 573
publication: 'Computational Geometry: Theory and Applications'
publication_status: published
publisher: Elsevier
publist_id: '4467'
quality_controlled: 0
status: public
title: 'Absolute approximation of Tukey depth: Theory and experiments'
type: journal_article
volume: 46
year: '2012'
...
---
_id: '244'
abstract:
- lang: eng
text: We investigate the solubility of the congruence xy ≡ 1 (mod p), where p is
a prime and x, y are restricted to lie in suitable short intervals. Our work relies
on a mean value theorem for incomplete Kloosterman sums.
acknowledgement: "EP/E053262/1\tEngineering and Physical Sciences Research Council\tEPSRC,\nEP/J00149X/1\tEngineering
and Physical Sciences Research Council\tEPSRC\t"
author:
- first_name: Timothy D
full_name: Timothy Browning
id: 35827D50-F248-11E8-B48F-1D18A9856A87
last_name: Browning
orcid: 0000-0002-8314-0177
- first_name: Alan
full_name: Haynes, Alan K
last_name: Haynes
citation:
ama: Browning TD, Haynes A. Incomplete kloosterman sums and multiplicative inverses
in short intervals. International Journal of Number Theory. 2012;9(2):481-486.
doi: https://doi.org/10.1142/S1793042112501448
apa: Browning, T. D., & Haynes, A. (2012). Incomplete kloosterman sums and multiplicative
inverses in short intervals. International Journal of Number Theory. World
Scientific Publishing. https://doi.org/
https://doi.org/10.1142/S1793042112501448
chicago: Browning, Timothy D, and Alan Haynes. “Incomplete Kloosterman Sums and
Multiplicative Inverses in Short Intervals.” International Journal of Number
Theory. World Scientific Publishing, 2012. https://doi.org/
https://doi.org/10.1142/S1793042112501448.
ieee: T. D. Browning and A. Haynes, “Incomplete kloosterman sums and multiplicative
inverses in short intervals,” International Journal of Number Theory, vol.
9, no. 2. World Scientific Publishing, pp. 481–486, 2012.
ista: Browning TD, Haynes A. 2012. Incomplete kloosterman sums and multiplicative
inverses in short intervals. International Journal of Number Theory. 9(2), 481–486.
mla: Browning, Timothy D., and Alan Haynes. “Incomplete Kloosterman Sums and Multiplicative
Inverses in Short Intervals.” International Journal of Number Theory, vol.
9, no. 2, World Scientific Publishing, 2012, pp. 481–86, doi: https://doi.org/10.1142/S1793042112501448.
short: T.D. Browning, A. Haynes, International Journal of Number Theory 9 (2012)
481–486.
date_created: 2018-12-11T11:45:24Z
date_published: 2012-11-30T00:00:00Z
date_updated: 2021-01-12T06:57:30Z
day: '30'
doi: ' https://doi.org/10.1142/S1793042112501448'
extern: 1
intvolume: ' 9'
issue: '2'
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1204.6374
month: '11'
oa: 1
page: 481 - 486
publication: International Journal of Number Theory
publication_status: published
publisher: World Scientific Publishing
publist_id: '7660'
quality_controlled: 0
status: public
title: Incomplete kloosterman sums and multiplicative inverses in short intervals
type: journal_article
volume: 9
year: '2012'
...
---
_id: '2440'
abstract:
- lang: eng
text: We present an algorithm for computing [X, Y], i.e., all homotopy classes of
continuous maps X → Y, where X, Y are topological spaces given as finite simplicial
complexes, Y is (d - 1)-connected for some d ≥ 2 (for example, Y can be the d-dimensional
sphere S d), and dim X ≤ 2d - 2. These conditions on X, Y guarantee that [X, Y]
has a natural structure of a finitely generated Abelian group, and the algorithm
finds generators and relations for it. We combine several tools and ideas from
homotopy theory (such as Postnikov systems, simplicial sets, and obstruction theory)
with algorithmic tools from effective algebraic topology (objects with effective
homology). We hope that a further extension of the methods developed here will
yield an algorithm for computing, in some cases of interest, the ℤ 2-index, which
is a quantity playing a prominent role in Borsuk-Ulam style applications of topology
in combinatorics and geometry, e.g., in topological lower bounds for the chromatic
number of a graph. In a certain range of dimensions, deciding the embeddability
of a simplicial complex into ℝ d also amounts to a ℤ 2-index computation. This
is the main motivation of our work. We believe that investigating the computational
complexity of questions in homotopy theory and similar areas presents a fascinating
research area, and we hope that our work may help bridge the cultural gap between
algebraic topology and theoretical computer science.
author:
- first_name: Martin
full_name: Čadek, Martin
last_name: Čadek
- first_name: Marek
full_name: Marek Krcál
id: 33E21118-F248-11E8-B48F-1D18A9856A87
last_name: Krcál
- first_name: Jiří
full_name: Matoušek, Jiří
last_name: Matoušek
- first_name: Francis
full_name: Sergeraert, Francis
last_name: Sergeraert
- first_name: Lukáš
full_name: Vokřínek, Lukáš
last_name: Vokřínek
- first_name: Uli
full_name: Uli Wagner
id: 36690CA2-F248-11E8-B48F-1D18A9856A87
last_name: Wagner
orcid: 0000-0002-1494-0568
citation:
ama: 'Čadek M, Krcál M, Matoušek J, Sergeraert F, Vokřínek L, Wagner U. Computing
all maps into a sphere. In: SIAM; 2012:1-10.'
apa: 'Čadek, M., Krcál, M., Matoušek, J., Sergeraert, F., Vokřínek, L., & Wagner,
U. (2012). Computing all maps into a sphere (pp. 1–10). Presented at the SODA:
Symposium on Discrete Algorithms, SIAM.'
chicago: Čadek, Martin, Marek Krcál, Jiří Matoušek, Francis Sergeraert, Lukáš Vokřínek,
and Uli Wagner. “Computing All Maps into a Sphere,” 1–10. SIAM, 2012.
ieee: 'M. Čadek, M. Krcál, J. Matoušek, F. Sergeraert, L. Vokřínek, and U. Wagner,
“Computing all maps into a sphere,” presented at the SODA: Symposium on Discrete
Algorithms, 2012, pp. 1–10.'
ista: 'Čadek M, Krcál M, Matoušek J, Sergeraert F, Vokřínek L, Wagner U. 2012. Computing
all maps into a sphere. SODA: Symposium on Discrete Algorithms, 1–10.'
mla: Čadek, Martin, et al. Computing All Maps into a Sphere. SIAM, 2012,
pp. 1–10.
short: M. Čadek, M. Krcál, J. Matoušek, F. Sergeraert, L. Vokřínek, U. Wagner, in:,
SIAM, 2012, pp. 1–10.
conference:
name: 'SODA: Symposium on Discrete Algorithms'
date_created: 2018-12-11T11:57:40Z
date_published: 2012-01-01T00:00:00Z
date_updated: 2021-01-12T06:57:30Z
day: '01'
extern: 1
main_file_link:
- open_access: '0'
url: http://arxiv.org/abs/1105.6257
month: '01'
page: 1 - 10
publication_status: published
publisher: SIAM
publist_id: '4466'
quality_controlled: 0
status: public
title: Computing all maps into a sphere
type: conference
year: '2012'
...
---
_id: '2441'
abstract:
- lang: eng
text: 'Eigenvalues associated to graphs are a well-studied subject. In particular
the spectra of the adjacency matrix and of the Laplacian of random graphs G(n,
p) are known quite precisely. We consider generalizations of these matrices to
simplicial complexes of higher dimensions and study their eigenvalues for the
Linial-Meshulam model X k(n, p) of random k-dimensional simplicial complexes on
n vertices. We show that for p = Ω(log n/n), the eigenvalues of both, the higher-dimensional
adjacency matrix and the Laplacian, are a.a.s. sharply concentrated around two
values. In a second part of the paper, we discuss a possible higherdimensional
analogue of the Discrete Cheeger Inequality. This fundamental inequality expresses
a close relationship between the eigenvalues of a graph and its combinatorial
expansion properties; in particular, spectral expansion (a large eigenvalue gap)
implies edge expansion. Recently, a higher-dimensional analogue of edge expansion
for simplicial complexes was introduced by Gromov, and independently by Linial,
Meshulam and Wallach and by Newman and Rabinovich. It is natural to ask whether
there is a higher-dimensional version of Cheeger''s inequality. We show that the
most straightforward version of a higher-dimensional Cheeger inequality fails:
for every k > 1, there is an infinite family of k-dimensional complexes that
are spectrally expanding (there is a large eigenvalue gap for the Laplacian) but
not combinatorially expanding.'
author:
- first_name: Anna
full_name: Gundert, Anna
last_name: Gundert
- first_name: Uli
full_name: Uli Wagner
id: 36690CA2-F248-11E8-B48F-1D18A9856A87
last_name: Wagner
orcid: 0000-0002-1494-0568
citation:
ama: 'Gundert A, Wagner U. On Laplacians of random complexes. In: ACM; 2012:151-160.
doi:10.1145/2261250.2261272'
apa: 'Gundert, A., & Wagner, U. (2012). On Laplacians of random complexes (pp.
151–160). Presented at the SGC: Symposuim on Computational Geometry, ACM. https://doi.org/10.1145/2261250.2261272'
chicago: Gundert, Anna, and Uli Wagner. “On Laplacians of Random Complexes,” 151–60.
ACM, 2012. https://doi.org/10.1145/2261250.2261272.
ieee: 'A. Gundert and U. Wagner, “On Laplacians of random complexes,” presented
at the SGC: Symposuim on Computational Geometry, 2012, pp. 151–160.'
ista: 'Gundert A, Wagner U. 2012. On Laplacians of random complexes. SGC: Symposuim
on Computational Geometry, 151–160.'
mla: Gundert, Anna, and Uli Wagner. On Laplacians of Random Complexes. ACM,
2012, pp. 151–60, doi:10.1145/2261250.2261272.
short: A. Gundert, U. Wagner, in:, ACM, 2012, pp. 151–160.
conference:
name: 'SGC: Symposuim on Computational Geometry'
date_created: 2018-12-11T11:57:41Z
date_published: 2012-06-01T00:00:00Z
date_updated: 2021-01-12T06:57:30Z
day: '01'
doi: 10.1145/2261250.2261272
extern: 1
month: '06'
page: 151 - 160
publication_status: published
publisher: ACM
publist_id: '4464'
quality_controlled: 0
status: public
title: On Laplacians of random complexes
type: conference
year: '2012'
...
---
_id: '2453'
abstract:
- lang: eng
text: Constitutive endocytic recycling is a crucial mechanism allowing regulation
of the activity of proteins at the plasma membrane and for rapid changes in their
localization, as demonstrated in plants for PIN-FORMED (PIN) proteins, the auxin
transporters. To identify novel molecular components of endocytic recycling, mainly
exocytosis, we designed a PIN1-green fluorescent protein fluorescence imaging-based
forward genetic screen for Arabidopsis thaliana mutants that showed increased
intracellular accumulation of cargos in response to the trafficking inhibitor
brefeldin A (BFA). We identified bex5 (for BFA-visualized exocytic trafficking
defective), a novel dominant mutant carrying a missense mutation that disrupts
a conserved sequence motif of the small GTPase, RAS GENES FROM RAT BRAINA1b. bex5
displays defects such as enhanced protein accumulation in abnormal BFA compartments,
aberrant endosomes, and defective exocytosis and transcytosis. BEX5/RabA1b localizes
to trans-Golgi network/early endosomes (TGN/EE) and acts on distinct trafficking
processes like those regulated by GTP exchange factors on ADP-ribosylation factors
GNOM-LIKE1 and HOPM INTERACTOR7/BFA-VISUALIZED ENDOCYTIC TRAFFICKING DEFECTIVE1,
which regulate trafficking at the Golgi apparatus and TGN/EE, respectively. All
together, this study identifies Arabidopsis BEX5/RabA1b as a novel regulator of
protein trafficking from a TGN/EE compartment to the plasma membrane.
author:
- first_name: Elena
full_name: Feraru, Elena
last_name: Feraru
- first_name: Mugurel
full_name: Feraru, Mugurel Ioan
last_name: Feraru
- first_name: Rin
full_name: Asaoka, Rin
last_name: Asaoka
- first_name: Tomasz
full_name: Paciorek, Tomasz
last_name: Paciorek
- first_name: Riet
full_name: De Rycke, Riet M
last_name: De Rycke
- first_name: Hirokazu
full_name: Tanaka, Hirokazu
last_name: Tanaka
- first_name: Akihiko
full_name: Nakano, Akihiko
last_name: Nakano
- first_name: Jirí
full_name: Jirí Friml
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Feraru E, Feraru M, Asaoka R, et al. BEX5/RabA1b regulates trans-Golgi network-to-plasma
membrane protein trafficking in Arabidopsis. Plant Cell. 2012;24(7):3074-3086.
doi:10.1105/tpc.112.098152
apa: Feraru, E., Feraru, M., Asaoka, R., Paciorek, T., De Rycke, R., Tanaka, H.,
… Friml, J. (2012). BEX5/RabA1b regulates trans-Golgi network-to-plasma membrane
protein trafficking in Arabidopsis. Plant Cell. American Society of Plant
Biologists. https://doi.org/10.1105/tpc.112.098152
chicago: Feraru, Elena, Mugurel Feraru, Rin Asaoka, Tomasz Paciorek, Riet De Rycke,
Hirokazu Tanaka, Akihiko Nakano, and Jiří Friml. “BEX5/RabA1b Regulates Trans-Golgi
Network-to-Plasma Membrane Protein Trafficking in Arabidopsis.” Plant Cell.
American Society of Plant Biologists, 2012. https://doi.org/10.1105/tpc.112.098152.
ieee: E. Feraru et al., “BEX5/RabA1b regulates trans-Golgi network-to-plasma
membrane protein trafficking in Arabidopsis,” Plant Cell, vol. 24, no.
7. American Society of Plant Biologists, pp. 3074–3086, 2012.
ista: Feraru E, Feraru M, Asaoka R, Paciorek T, De Rycke R, Tanaka H, Nakano A,
Friml J. 2012. BEX5/RabA1b regulates trans-Golgi network-to-plasma membrane protein
trafficking in Arabidopsis. Plant Cell. 24(7), 3074–3086.
mla: Feraru, Elena, et al. “BEX5/RabA1b Regulates Trans-Golgi Network-to-Plasma
Membrane Protein Trafficking in Arabidopsis.” Plant Cell, vol. 24, no.
7, American Society of Plant Biologists, 2012, pp. 3074–86, doi:10.1105/tpc.112.098152.
short: E. Feraru, M. Feraru, R. Asaoka, T. Paciorek, R. De Rycke, H. Tanaka, A.
Nakano, J. Friml, Plant Cell 24 (2012) 3074–3086.
date_created: 2018-12-11T11:57:45Z
date_published: 2012-07-01T00:00:00Z
date_updated: 2021-01-12T06:57:35Z
day: '01'
doi: 10.1105/tpc.112.098152
extern: 1
intvolume: ' 24'
issue: '7'
month: '07'
page: 3074 - 3086
publication: Plant Cell
publication_status: published
publisher: American Society of Plant Biologists
publist_id: '4450'
quality_controlled: 0
status: public
title: BEX5/RabA1b regulates trans-Golgi network-to-plasma membrane protein trafficking
in Arabidopsis
type: journal_article
volume: 24
year: '2012'
...
---
_id: '2456'
abstract:
- lang: eng
text: The third EMBO Conference on Plant Molecular Biology, which focused on ‘Plant
development and environmental interactions’,was held in May 2012 in Matera, Italy.
Here, we review some of the topics and themes that emerged from the various
contributions; namely, steering technologies, transcriptional networks and hormonal
regulation, small RNAs, cell and tissue polarity, environmental control and natural
variation. We intend to provide the reader who might have missed this remarkable
event with a glimpse of the recent progress made in this blossoming research field.
author:
- first_name: Tom
full_name: Beeckman, Tom
last_name: Beeckman
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Beeckman T, Friml J. Plant developmental biologists meet on stairways in Matera.
Development. 2012;139(20):3677-3682. doi:10.1242/dev.080861
apa: Beeckman, T., & Friml, J. (2012). Plant developmental biologists meet on
stairways in Matera. Development. Company of Biologists. https://doi.org/10.1242/dev.080861
chicago: Beeckman, Tom, and Jiří Friml. “Plant Developmental Biologists Meet on
Stairways in Matera.” Development. Company of Biologists, 2012. https://doi.org/10.1242/dev.080861.
ieee: T. Beeckman and J. Friml, “Plant developmental biologists meet on stairways
in Matera,” Development, vol. 139, no. 20. Company of Biologists, pp. 3677–3682,
2012.
ista: Beeckman T, Friml J. 2012. Plant developmental biologists meet on stairways
in Matera. Development. 139(20), 3677–3682.
mla: Beeckman, Tom, and Jiří Friml. “Plant Developmental Biologists Meet on Stairways
in Matera.” Development, vol. 139, no. 20, Company of Biologists, 2012,
pp. 3677–82, doi:10.1242/dev.080861.
short: T. Beeckman, J. Friml, Development 139 (2012) 3677–3682.
date_created: 2018-12-11T11:57:46Z
date_published: 2012-10-15T00:00:00Z
date_updated: 2021-01-12T06:57:35Z
day: '15'
doi: 10.1242/dev.080861
extern: '1'
intvolume: ' 139'
issue: '20'
language:
- iso: eng
month: '10'
oa_version: None
page: 3677 - 3682
publication: Development
publication_status: published
publisher: Company of Biologists
publist_id: '4447'
quality_controlled: '1'
status: public
title: Plant developmental biologists meet on stairways in Matera
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 139
year: '2012'
...
---
_id: '2458'
abstract:
- lang: eng
text: Initiation and successive development of organs induce mechanical stresses
at the cellular level. Using the tomato shoot apex, a new study now proposes that
mechanical strain regulates the plasma membrane abundance of the PIN1 auxin transporter,
thereby reinforcing a positive feed-back loop between growth and auxin accumulation.
author:
- first_name: Hongjiang
full_name: Li, Hongjiang
id: 33CA54A6-F248-11E8-B48F-1D18A9856A87
last_name: Li
orcid: 0000-0001-5039-9660
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Wim
full_name: Grunewald, Wim
last_name: Grunewald
citation:
ama: 'Li H, Friml J, Grunewald W. Cell polarity: Stretching prevents developmental
cramps. Current Biology. 2012;22(16):R635-R637. doi:10.1016/j.cub.2012.06.053'
apa: 'Li, H., Friml, J., & Grunewald, W. (2012). Cell polarity: Stretching prevents
developmental cramps. Current Biology. Cell Press. https://doi.org/10.1016/j.cub.2012.06.053'
chicago: 'Li, Hongjiang, Jiří Friml, and Wim Grunewald. “Cell Polarity: Stretching
Prevents Developmental Cramps.” Current Biology. Cell Press, 2012. https://doi.org/10.1016/j.cub.2012.06.053.'
ieee: 'H. Li, J. Friml, and W. Grunewald, “Cell polarity: Stretching prevents developmental
cramps,” Current Biology, vol. 22, no. 16. Cell Press, pp. R635–R637, 2012.'
ista: 'Li H, Friml J, Grunewald W. 2012. Cell polarity: Stretching prevents developmental
cramps. Current Biology. 22(16), R635–R637.'
mla: 'Li, Hongjiang, et al. “Cell Polarity: Stretching Prevents Developmental Cramps.”
Current Biology, vol. 22, no. 16, Cell Press, 2012, pp. R635–37, doi:10.1016/j.cub.2012.06.053.'
short: H. Li, J. Friml, W. Grunewald, Current Biology 22 (2012) R635–R637.
date_created: 2018-12-11T11:57:47Z
date_published: 2012-08-21T00:00:00Z
date_updated: 2021-01-12T06:57:36Z
day: '21'
doi: 10.1016/j.cub.2012.06.053
extern: '1'
intvolume: ' 22'
issue: '16'
language:
- iso: eng
month: '08'
oa_version: None
page: R635 - R637
publication: Current Biology
publication_status: published
publisher: Cell Press
publist_id: '4445'
quality_controlled: '1'
status: public
title: 'Cell polarity: Stretching prevents developmental cramps'
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 22
year: '2012'
...
---
_id: '2459'
abstract:
- lang: eng
text: Coordinated, subcellular trafficking of proteins is one of the fundamental
properties of the multicellular eukaryotic organisms. Trafficking involves a large
diversity of compartments, pathways, cargo molecules, and vesicle-sorting events.
It is also crucial in regulating the localization and, thus, the activity of various
proteins, but the process is still poorly genetically defined in plants. In the
past, forward genetics screens had been used to determine the function of genes
by searching for a specific morphological phenotype in the organism population
in which mutations had been induced chemically or by irradiation. Unfortunately,
these straightforward genetic screens turned out to be limited in identifying
new regulators of intracellular protein transport, because mutations affecting
essential trafficking pathways often lead to lethality. In addition, the use of
these approaches has been restricted by functional redundancy among trafficking
regulators. Screens for mutants that rely on the observation of changes in the
cellular localization or dynamics of fluorescent subcellular markers enable, at
least partially, to circumvent these issues. Hence, such image-based screens provide
the possibility to identify either alleles with weak effects or components of
the subcellular trafficking machinery that have no strong impact on the plant
growth.
article_number: '97'
author:
- first_name: Marta
full_name: Zwiewka, Marta
last_name: Zwiewka
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Zwiewka M, Friml J. Fluorescence imaging-based forward genetic screens to identify
trafficking regulators in plants. Frontiers in Plant Science. 2012;3(May).
doi:10.3389/fpls.2012.00097
apa: Zwiewka, M., & Friml, J. (2012). Fluorescence imaging-based forward genetic
screens to identify trafficking regulators in plants. Frontiers in Plant Science.
Frontiers Research Foundation. https://doi.org/10.3389/fpls.2012.00097
chicago: Zwiewka, Marta, and Jiří Friml. “Fluorescence Imaging-Based Forward Genetic
Screens to Identify Trafficking Regulators in Plants.” Frontiers in Plant Science.
Frontiers Research Foundation, 2012. https://doi.org/10.3389/fpls.2012.00097.
ieee: M. Zwiewka and J. Friml, “Fluorescence imaging-based forward genetic screens
to identify trafficking regulators in plants,” Frontiers in Plant Science,
vol. 3, no. May. Frontiers Research Foundation, 2012.
ista: Zwiewka M, Friml J. 2012. Fluorescence imaging-based forward genetic screens
to identify trafficking regulators in plants. Frontiers in Plant Science. 3(May),
97.
mla: Zwiewka, Marta, and Jiří Friml. “Fluorescence Imaging-Based Forward Genetic
Screens to Identify Trafficking Regulators in Plants.” Frontiers in Plant Science,
vol. 3, no. May, 97, Frontiers Research Foundation, 2012, doi:10.3389/fpls.2012.00097.
short: M. Zwiewka, J. Friml, Frontiers in Plant Science 3 (2012).
date_created: 2018-12-11T11:57:47Z
date_published: 2012-05-24T00:00:00Z
date_updated: 2021-01-12T06:57:36Z
day: '24'
ddc:
- '580'
doi: 10.3389/fpls.2012.00097
extern: '1'
file:
- access_level: open_access
checksum: ab4e9487ccdb83a7a0a9ee6811521844
content_type: application/pdf
creator: kschuh
date_created: 2019-04-26T06:49:26Z
date_updated: 2020-07-14T12:45:41Z
file_id: '6346'
file_name: 2012_frontiers_Zwiewka.pdf
file_size: 1468230
relation: main_file
file_date_updated: 2020-07-14T12:45:41Z
has_accepted_license: '1'
intvolume: ' 3'
issue: May
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc/4.0/
month: '05'
oa: 1
oa_version: Published Version
publication: Frontiers in Plant Science
publication_status: published
publisher: Frontiers Research Foundation
publist_id: '4444'
quality_controlled: '1'
status: public
title: Fluorescence imaging-based forward genetic screens to identify trafficking
regulators in plants
tmp:
image: /images/cc_by_nc.png
legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
short: CC BY-NC (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 3
year: '2012'
...
---
_id: '2474'
abstract:
- lang: eng
text: 'Interneurons are critical for neuronal circuit function, but how their dendritic
morphologies and membrane properties influence information flow within neuronal
circuits is largely unknown. We studied the spatiotemporal profile of synaptic
integration and short-term plasticity in dendrites of mature cerebellar stellate
cells by combining two-photon guided electrical stimulation, glutamate uncaging,
electron microscopy, and modeling. Synaptic activation within thin (0.4 μm) dendrites
produced somatic responses that became smaller and slower with increasing distance
from the soma, sublinear subthreshold input-output relationships, and a somatodendritic
gradient of short-term plasticity. Unlike most studies showing that neurons employ
active dendritic mechanisms, we found that passive cable properties of thin dendrites
determine the sublinear integration and plasticity gradient, which both result
from large dendritic depolarizations that reduce synaptic driving force. These
integrative properties allow stellate cells to act as spatiotemporal filters of
synaptic input patterns, thereby biasing their output in favor of sparse presynaptic
activity. Stellate cells are critical sources of inhibition in the cerebellum,
but how their dendrites integrate excitatory synaptic inputs is unknown. Abrahamsson
et al. show that thin dendrites and passive membrane properties of SCs promote
sublinear synaptic summation and distance-dependent short-term plasticity. '
author:
- first_name: Therese
full_name: Abrahamsson, Therese
last_name: Abrahamsson
- first_name: Laurence
full_name: Cathala, Laurence
last_name: Cathala
- first_name: Ko
full_name: Matsui, Ko
last_name: Matsui
- first_name: Ryuichi
full_name: Ryuichi Shigemoto
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: David
full_name: DiGregorio, David A
last_name: Digregorio
citation:
ama: Abrahamsson T, Cathala L, Matsui K, Shigemoto R, Digregorio D. Thin dendrites
of cerebellar interneurons confer sublinear synaptic integration and a gradient
of short-term plasticity. Neuron. 2012;73(6):1159-1172. doi:10.1016/j.neuron.2012.01.027
apa: Abrahamsson, T., Cathala, L., Matsui, K., Shigemoto, R., & Digregorio,
D. (2012). Thin dendrites of cerebellar interneurons confer sublinear synaptic
integration and a gradient of short-term plasticity. Neuron. Elsevier.
https://doi.org/10.1016/j.neuron.2012.01.027
chicago: Abrahamsson, Therese, Laurence Cathala, Ko Matsui, Ryuichi Shigemoto, and
David Digregorio. “Thin Dendrites of Cerebellar Interneurons Confer Sublinear
Synaptic Integration and a Gradient of Short-Term Plasticity.” Neuron.
Elsevier, 2012. https://doi.org/10.1016/j.neuron.2012.01.027.
ieee: T. Abrahamsson, L. Cathala, K. Matsui, R. Shigemoto, and D. Digregorio, “Thin
dendrites of cerebellar interneurons confer sublinear synaptic integration and
a gradient of short-term plasticity,” Neuron, vol. 73, no. 6. Elsevier,
pp. 1159–1172, 2012.
ista: Abrahamsson T, Cathala L, Matsui K, Shigemoto R, Digregorio D. 2012. Thin
dendrites of cerebellar interneurons confer sublinear synaptic integration and
a gradient of short-term plasticity. Neuron. 73(6), 1159–1172.
mla: Abrahamsson, Therese, et al. “Thin Dendrites of Cerebellar Interneurons Confer
Sublinear Synaptic Integration and a Gradient of Short-Term Plasticity.” Neuron,
vol. 73, no. 6, Elsevier, 2012, pp. 1159–72, doi:10.1016/j.neuron.2012.01.027.
short: T. Abrahamsson, L. Cathala, K. Matsui, R. Shigemoto, D. Digregorio, Neuron
73 (2012) 1159–1172.
date_created: 2018-12-11T11:57:52Z
date_published: 2012-03-22T00:00:00Z
date_updated: 2021-01-12T06:57:42Z
day: '22'
doi: 10.1016/j.neuron.2012.01.027
extern: 1
intvolume: ' 73'
issue: '6'
month: '03'
page: 1159 - 1172
publication: Neuron
publication_status: published
publisher: Elsevier
publist_id: '4427'
quality_controlled: 0
status: public
title: Thin dendrites of cerebellar interneurons confer sublinear synaptic integration
and a gradient of short-term plasticity
type: journal_article
volume: 73
year: '2012'
...
---
_id: '2475'
abstract:
- lang: eng
text: 'Background: One of the best-characterized causative factors of Alzheimer''s
disease (AD) is the generation of amyloid-β peptide (Aβ). AD subjects are at high
risk of epileptic seizures accompanied by aberrant neuronal excitability, which
in itself enhances Aβ generation. However, the molecular linkage between epileptic
seizures and Aβ generation in AD remains unclear. Results: X11 and X11-like (X11L)
gene knockout mice suffered from epileptic seizures, along with a malfunction
of hyperpolarization-activated cyclic nucleotide gated (HCN) channels. Genetic
ablation of HCN1 in mice and HCN1 channel blockage in cultured Neuro2a (N2a) cells
enhanced Aβ generation. Interestingly, HCN1 levels dramatically decreased in the
temporal lobe of cynomolgus monkeys (Macaca fascicularis) during aging and were
significantly diminished in the temporal lobe of sporadic AD patients. Conclusion:
Because HCN1 associates with amyloid-β precursor protein (APP) and X11/X11L in
the brain, genetic deficiency of X11/X11L may induce aberrant HCN1 distribution
along with epilepsy. Moreover, the reduction in HCN1 levels in aged primates may
contribute to augmented Aβ generation. Taken together, HCN1 is proposed to play
an important role in the molecular linkage between epileptic seizures and Aβ generation,
and in the aggravation of sporadic AD.'
author:
- first_name: Yuhki
full_name: Saito, Yuhki
last_name: Saito
- first_name: Tsuyoshi
full_name: Inoue, Tsuyoshi
last_name: Inoue
- first_name: Gang
full_name: Zhu, Gang
last_name: Zhu
- first_name: Naoki
full_name: Kimura, Naoki
last_name: Kimura
- first_name: Motohiro
full_name: Okada, Motohiro
last_name: Okada
- first_name: Masaki
full_name: Nishimura, Masaki
last_name: Nishimura
- first_name: Shigeo
full_name: Murayama, Shigeo
last_name: Murayama
- first_name: Sunao
full_name: Kaneko, Sunao
last_name: Kaneko
- first_name: Ryuichi
full_name: Ryuichi Shigemoto
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Keiji
full_name: Imoto, Keiji
last_name: Imoto
- first_name: Toshiharu
full_name: Suzuki, Toshiharu
last_name: Suzuki
citation:
ama: 'Saito Y, Inoue T, Zhu G, et al. Hyperpolarization-activated cyclic nucleotide
gated channels: A potential molecular link between epileptic seizures and Aβ generation
in Alzheimer’s disease. Molecular Neurodegeneration. 2012;7(1). doi:10.1186/1750-1326-7-50'
apa: 'Saito, Y., Inoue, T., Zhu, G., Kimura, N., Okada, M., Nishimura, M., … Suzuki,
T. (2012). Hyperpolarization-activated cyclic nucleotide gated channels: A potential
molecular link between epileptic seizures and Aβ generation in Alzheimer’s disease.
Molecular Neurodegeneration. BioMed Central. https://doi.org/10.1186/1750-1326-7-50'
chicago: 'Saito, Yuhki, Tsuyoshi Inoue, Gang Zhu, Naoki Kimura, Motohiro Okada,
Masaki Nishimura, Shigeo Murayama, et al. “Hyperpolarization-Activated Cyclic
Nucleotide Gated Channels: A Potential Molecular Link between Epileptic Seizures
and Aβ Generation in Alzheimer’s Disease.” Molecular Neurodegeneration.
BioMed Central, 2012. https://doi.org/10.1186/1750-1326-7-50.'
ieee: 'Y. Saito et al., “Hyperpolarization-activated cyclic nucleotide gated
channels: A potential molecular link between epileptic seizures and Aβ generation
in Alzheimer’s disease,” Molecular Neurodegeneration, vol. 7, no. 1. BioMed
Central, 2012.'
ista: 'Saito Y, Inoue T, Zhu G, Kimura N, Okada M, Nishimura M, Murayama S, Kaneko
S, Shigemoto R, Imoto K, Suzuki T. 2012. Hyperpolarization-activated cyclic nucleotide
gated channels: A potential molecular link between epileptic seizures and Aβ generation
in Alzheimer’s disease. Molecular Neurodegeneration. 7(1).'
mla: 'Saito, Yuhki, et al. “Hyperpolarization-Activated Cyclic Nucleotide Gated
Channels: A Potential Molecular Link between Epileptic Seizures and Aβ Generation
in Alzheimer’s Disease.” Molecular Neurodegeneration, vol. 7, no. 1, BioMed
Central, 2012, doi:10.1186/1750-1326-7-50.'
short: Y. Saito, T. Inoue, G. Zhu, N. Kimura, M. Okada, M. Nishimura, S. Murayama,
S. Kaneko, R. Shigemoto, K. Imoto, T. Suzuki, Molecular Neurodegeneration 7 (2012).
date_created: 2018-12-11T11:57:53Z
date_published: 2012-10-03T00:00:00Z
date_updated: 2021-01-12T06:57:42Z
day: '03'
doi: 10.1186/1750-1326-7-50
extern: 1
intvolume: ' 7'
issue: '1'
month: '10'
publication: Molecular Neurodegeneration
publication_status: published
publisher: BioMed Central
publist_id: '4426'
quality_controlled: 0
status: public
title: 'Hyperpolarization-activated cyclic nucleotide gated channels: A potential
molecular link between epileptic seizures and Aβ generation in Alzheimer''s disease'
type: journal_article
volume: 7
year: '2012'
...
---
_id: '2476'
abstract:
- lang: eng
text: Recently developed pharmacogenetic and optogenetic approaches, with their
own advantages and disadvantages, have become indispensable tools in modern neuroscience.
Here, we employed a previously described knock-in mouse line (GABA ARγ2 77Ilox)
in which the γ2 subunit of the GABA A receptor (GABA AR) was mutated to become
zolpidem insensitive (γ2 77I) and used viral vectors to swap γ2 77I with wild-type,
zolpidem-sensitive γ2 subunits (γ2 77F). The verification of unaltered density
and subcellular distribution of the virally introduced γ2 subunits requires their
selective labelling. For this we generated six N- and six C-terminal-tagged γ2
subunits, with which cortical cultures of GABA ARγ2 -/- mice were transduced using
lentiviruses. We found that the N-terminal AU1 tag resulted in excellent immunodetection
and unimpaired synaptic localization. Unaltered kinetic properties of the AU1-tagged
γ2 ( AU1γ2 77F) channels were demonstrated with whole-cell patch-clamp recordings
of spontaneous IPSCs from cultured cells. Next, we carried out stereotaxic injections
of lenti- and adeno-associated viruses containing Cre-recombinase and the AU1γ2
77F subunit (Cre-2A- AU1γ2 77F) into the neocortex of GABA ARγ2 77Ilox mice. Light
microscopic immunofluorescence and electron microscopic freeze-fracture replica
immunogold labelling demonstrated the efficient immunodetection of the AU1 tag
and the normal enrichment of the AU1γ2 77F subunits in perisomatic GABAergic synapses.
In line with this, miniature and action potential-evoked IPSCs whole-cell recorded
from transduced cells had unaltered amplitudes, kinetics and restored zolpidem
sensitivity. Our results obtained with a wide range of structural and functional
verification methods reveal unaltered subcellular distributions and functional
properties of γ2 77I and AU1γ2 77F GABA ARs in cortical pyramidal cells. This
transgenic-viral pharmacogenetic approach has the advantage that it does not require
any extrinsic protein that might endow some unforeseen alterations of the genetically
modified cells. In addition, this virus-based approach opens up the possibility
of modifying multiple cell types in distinct brain regions and performing alternative
recombination-based intersectional genetic manipulations.
author:
- first_name: Máté
full_name: Sümegi, Máté
last_name: Sümegi
- first_name: Yugo
full_name: Fukazawa, Yugo
last_name: Fukazawa
- first_name: Ko
full_name: Matsui, Ko
last_name: Matsui
- first_name: Andrea
full_name: Lörincz, Andrea
last_name: Lörincz
- first_name: Mark
full_name: Eyre, Mark D
last_name: Eyre
- first_name: Zoltán
full_name: Nusser, Zoltán
last_name: Nusser
- first_name: Ryuichi
full_name: Ryuichi Shigemoto
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
citation:
ama: Sümegi M, Fukazawa Y, Matsui K, et al. Virus-mediated swapping of zolpidem-insensitive
with zolpidem-sensitive GABA A receptors in cortical pyramidal cells. Journal
of Physiology. 2012;590(7):1517-1534. doi:10.1113/jphysiol.2012.227538
apa: Sümegi, M., Fukazawa, Y., Matsui, K., Lörincz, A., Eyre, M., Nusser, Z., &
Shigemoto, R. (2012). Virus-mediated swapping of zolpidem-insensitive with zolpidem-sensitive
GABA A receptors in cortical pyramidal cells. Journal of Physiology. Wiley-Blackwell.
https://doi.org/10.1113/jphysiol.2012.227538
chicago: Sümegi, Máté, Yugo Fukazawa, Ko Matsui, Andrea Lörincz, Mark Eyre, Zoltán
Nusser, and Ryuichi Shigemoto. “Virus-Mediated Swapping of Zolpidem-Insensitive
with Zolpidem-Sensitive GABA A Receptors in Cortical Pyramidal Cells.” Journal
of Physiology. Wiley-Blackwell, 2012. https://doi.org/10.1113/jphysiol.2012.227538.
ieee: M. Sümegi et al., “Virus-mediated swapping of zolpidem-insensitive
with zolpidem-sensitive GABA A receptors in cortical pyramidal cells,” Journal
of Physiology, vol. 590, no. 7. Wiley-Blackwell, pp. 1517–1534, 2012.
ista: Sümegi M, Fukazawa Y, Matsui K, Lörincz A, Eyre M, Nusser Z, Shigemoto R.
2012. Virus-mediated swapping of zolpidem-insensitive with zolpidem-sensitive
GABA A receptors in cortical pyramidal cells. Journal of Physiology. 590(7), 1517–1534.
mla: Sümegi, Máté, et al. “Virus-Mediated Swapping of Zolpidem-Insensitive with
Zolpidem-Sensitive GABA A Receptors in Cortical Pyramidal Cells.” Journal of
Physiology, vol. 590, no. 7, Wiley-Blackwell, 2012, pp. 1517–34, doi:10.1113/jphysiol.2012.227538.
short: M. Sümegi, Y. Fukazawa, K. Matsui, A. Lörincz, M. Eyre, Z. Nusser, R. Shigemoto,
Journal of Physiology 590 (2012) 1517–1534.
date_created: 2018-12-11T11:57:53Z
date_published: 2012-04-07T00:00:00Z
date_updated: 2021-01-12T06:57:43Z
day: '07'
doi: 10.1113/jphysiol.2012.227538
extern: 1
intvolume: ' 590'
issue: '7'
month: '04'
page: 1517 - 1534
publication: Journal of Physiology
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4425'
quality_controlled: 0
status: public
title: Virus-mediated swapping of zolpidem-insensitive with zolpidem-sensitive GABA
A receptors in cortical pyramidal cells
type: journal_article
volume: 590
year: '2012'
...
---
_id: '2477'
abstract:
- lang: eng
text: Dynamic activity of glia has repeatedly been demonstrated, but if such activity
is independent from neuronal activity, glia would not have any role in the information
processing in the brain or in the generation of animal behavior. Evidence for
neurons communicating with glia is solid, but the signaling pathway leading back
from glial-to-neuronal activity was often difficult to study. Here, we introduced
a transgenic mouse line in which channelrhodopsin-2, a light-gated cation channel,
was expressed in astrocytes. Selective photostimulation of these astrocytes in
vivo triggered neuronal activation. Using slice preparations, we show that glial
photostimulation leads to release of glutamate, which was sufficient to activate
AMPA receptors on Purkinje cells and to induce long-term depression of parallel
fiber-to-Purkinje cell synapses through activation of metabotropic glutamate receptors.
In contrast to neuronal synaptic vesicular release, glial activation likely causes
preferential activation of extrasynaptic receptors that appose glial membrane.
Finally, we show that neuronal activation by glial stimulation can lead to perturbation
of cerebellar modulated motor behavior. These findings demonstrate that glia can
modulate the tone of neuronal activity and behavior. This animal model is expected
to be a potentially powerful approach to study the role of glia in brain function.
author:
- first_name: Takuya
full_name: Sasaki, Takuya
last_name: Sasaki
- first_name: Kaoru
full_name: Beppu, Kaoru
last_name: Beppu
- first_name: Kenji
full_name: Tanaka, Kenji F
last_name: Tanaka
- first_name: Yugo
full_name: Fukazawa, Yugo
last_name: Fukazawa
- first_name: Ryuichi
full_name: Ryuichi Shigemoto
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Ko
full_name: Matsui, Ko
last_name: Matsui
citation:
ama: Sasaki T, Beppu K, Tanaka K, Fukazawa Y, Shigemoto R, Matsui K. Application
of an optogenetic byway for perturbing neuronal activity via glial photostimulation.
PNAS. 2012;109(50):20720-20725. doi:10.1073/pnas.1213458109
apa: Sasaki, T., Beppu, K., Tanaka, K., Fukazawa, Y., Shigemoto, R., & Matsui,
K. (2012). Application of an optogenetic byway for perturbing neuronal activity
via glial photostimulation. PNAS. National Academy of Sciences. https://doi.org/10.1073/pnas.1213458109
chicago: Sasaki, Takuya, Kaoru Beppu, Kenji Tanaka, Yugo Fukazawa, Ryuichi Shigemoto,
and Ko Matsui. “Application of an Optogenetic Byway for Perturbing Neuronal Activity
via Glial Photostimulation.” PNAS. National Academy of Sciences, 2012.
https://doi.org/10.1073/pnas.1213458109.
ieee: T. Sasaki, K. Beppu, K. Tanaka, Y. Fukazawa, R. Shigemoto, and K. Matsui,
“Application of an optogenetic byway for perturbing neuronal activity via glial
photostimulation,” PNAS, vol. 109, no. 50. National Academy of Sciences,
pp. 20720–20725, 2012.
ista: Sasaki T, Beppu K, Tanaka K, Fukazawa Y, Shigemoto R, Matsui K. 2012. Application
of an optogenetic byway for perturbing neuronal activity via glial photostimulation.
PNAS. 109(50), 20720–20725.
mla: Sasaki, Takuya, et al. “Application of an Optogenetic Byway for Perturbing
Neuronal Activity via Glial Photostimulation.” PNAS, vol. 109, no. 50,
National Academy of Sciences, 2012, pp. 20720–25, doi:10.1073/pnas.1213458109.
short: T. Sasaki, K. Beppu, K. Tanaka, Y. Fukazawa, R. Shigemoto, K. Matsui, PNAS
109 (2012) 20720–20725.
date_created: 2018-12-11T11:57:54Z
date_published: 2012-12-11T00:00:00Z
date_updated: 2021-01-12T06:57:43Z
day: '11'
doi: 10.1073/pnas.1213458109
extern: 1
intvolume: ' 109'
issue: '50'
month: '12'
page: 20720 - 20725
publication: PNAS
publication_status: published
publisher: National Academy of Sciences
publist_id: '4424'
quality_controlled: 0
status: public
title: Application of an optogenetic byway for perturbing neuronal activity via glial
photostimulation
type: journal_article
volume: 109
year: '2012'
...
---
_id: '2514'
abstract:
- lang: eng
text: Visual information must be relayed through the lateral geniculate nucleus
before it reaches the visual cortex. However, not all spikes created in the retina
lead to postsynaptic spikes and properties of the retinogeniculate synapse contribute
to this filtering. To understand the mechanisms underlying this filtering process,
we conducted electrophysiology to assess the properties of signal transmission
in the Long-Evans rat. We also performed SDS-digested freeze-fracture replica
labeling to quantify the receptor and transporter distribution, as well as EM
reconstruction to describe the 3D structure. To analyze the impact of transmitter
diffusion on the activity of the receptors, simulations were integrated. We identified
that a large contributor to the filtering is the marked paired-pulse depression
at this synapse, which was intensified by the morphological characteristics of
the contacts. The broad presynaptic and postsynaptic contact area restricts transmitter
diffusion two dimensionally. Additionally, the presence of multiple closely arranged
release sites invites intersynaptic spillover, which causes desensitization of
AMPA receptors. The presence of AMPA receptors that slowly recover from desensitization
along with the high presynaptic release probability and multivesicular release
at each synapse also contribute to the depression. These features contrast with
many other synapses where spatiotemporal spread of transmitter is limited by rapid
transmitter clearance allowing synapses to operate more independently. We propose
that the micrometer-order structure can ultimately affect the visual information
processing.
author:
- first_name: Timotheus
full_name: Budisantoso, Timotheus
last_name: Budisantoso
- first_name: Ko
full_name: Matsui, Ko
last_name: Matsui
- first_name: Naomi
full_name: Kamasawa, Naomi
last_name: Kamasawa
- first_name: Yugo
full_name: Fukazawa, Yugo
last_name: Fukazawa
- first_name: Ryuichi
full_name: Ryuichi Shigemoto
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
citation:
ama: Budisantoso T, Matsui K, Kamasawa N, Fukazawa Y, Shigemoto R. Mechanisms underlying
signal filtering at a multisynapse contact. Journal of Neuroscience. 2012;32(7):2357-2376.
doi:10.1523/JNEUROSCI.5243-11.2012
apa: Budisantoso, T., Matsui, K., Kamasawa, N., Fukazawa, Y., & Shigemoto, R.
(2012). Mechanisms underlying signal filtering at a multisynapse contact. Journal
of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.5243-11.2012
chicago: Budisantoso, Timotheus, Ko Matsui, Naomi Kamasawa, Yugo Fukazawa, and Ryuichi
Shigemoto. “Mechanisms Underlying Signal Filtering at a Multisynapse Contact.”
Journal of Neuroscience. Society for Neuroscience, 2012. https://doi.org/10.1523/JNEUROSCI.5243-11.2012.
ieee: T. Budisantoso, K. Matsui, N. Kamasawa, Y. Fukazawa, and R. Shigemoto, “Mechanisms
underlying signal filtering at a multisynapse contact,” Journal of Neuroscience,
vol. 32, no. 7. Society for Neuroscience, pp. 2357–2376, 2012.
ista: Budisantoso T, Matsui K, Kamasawa N, Fukazawa Y, Shigemoto R. 2012. Mechanisms
underlying signal filtering at a multisynapse contact. Journal of Neuroscience.
32(7), 2357–2376.
mla: Budisantoso, Timotheus, et al. “Mechanisms Underlying Signal Filtering at a
Multisynapse Contact.” Journal of Neuroscience, vol. 32, no. 7, Society
for Neuroscience, 2012, pp. 2357–76, doi:10.1523/JNEUROSCI.5243-11.2012.
short: T. Budisantoso, K. Matsui, N. Kamasawa, Y. Fukazawa, R. Shigemoto, Journal
of Neuroscience 32 (2012) 2357–2376.
date_created: 2018-12-11T11:58:07Z
date_published: 2012-02-15T00:00:00Z
date_updated: 2021-01-12T06:57:57Z
day: '15'
doi: 10.1523/JNEUROSCI.5243-11.2012
extern: 1
intvolume: ' 32'
issue: '7'
month: '02'
page: 2357 - 2376
publication: Journal of Neuroscience
publication_status: published
publisher: Society for Neuroscience
publist_id: '4387'
quality_controlled: 0
status: public
title: Mechanisms underlying signal filtering at a multisynapse contact
type: journal_article
volume: 32
year: '2012'
...
---
_id: '2515'
abstract:
- lang: eng
text: We investigated the temporal and spatial expression of SK2 in the developing
mouse hippocampus using molecular and biochemical techniques, quantitative immunogold
electron microscopy, and electrophysiology. The mRNA encoding SK2 was expressed
in the developing and adult hippocampus. Western blotting and immunohistochemistry
showed that SK2 protein increased with age. This was accompanied by a shift in
subcellular localization. Early in development (P5), SK2 was predominantly localized
to the endoplasmic reticulum in the pyramidal cell layer. But by P30 SK2 was almost
exclusively expressed in the dendrites and spines. The level of SK2 at the postsynaptic
density (PSD) also increased during development. In the adult, SK2 expression
on the spine plasma membrane showed a proximal-to-distal gradient. Consistent
with this redistribution and gradient of SK2, the selective SK channel blocker
apamin increased evoked excitatory postsynaptic potentials (EPSPs) only in CA1
pyramidal neurons from mice older than P15. However, the effect of apamin on EPSPs
was not different between synapses in proximal or distal stratum radiatum or stratum
lacunosum-moleculare in adult. These results show a developmental increase and
gradient in SK2-containing channel surface expression that underlie their influence
on neurotransmission, and that may contribute to increased memory acquisition
during early development.
author:
- first_name: Carmen
full_name: Ballesteros-Merino, Carmen
last_name: Ballesteros Merino
- first_name: Michael
full_name: Lin, Michael
last_name: Lin
- first_name: Wendy
full_name: Wu, Wendy W
last_name: Wu
- first_name: Clotilde
full_name: Ferrándiz-Huertas, Clotilde
last_name: Ferrándiz Huertas
- first_name: María
full_name: Cabañero, María José
last_name: Cabañero
- first_name: Masahiko
full_name: Watanabe, Masahiko
last_name: Watanabe
- first_name: Yugo
full_name: Fukazawa, Yugo
last_name: Fukazawa
- first_name: Ryuichi
full_name: Ryuichi Shigemoto
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: James
full_name: Maylie, James G
last_name: Maylie
- first_name: John
full_name: Adelman, John P
last_name: Adelman
- first_name: Rafael
full_name: Luján, Rafael
last_name: Luján
citation:
ama: Ballesteros Merino C, Lin M, Wu W, et al. Developmental profile of SK2 channel
expression and function in CA1 neurons. Hippocampus. 2012;22(6):1467-1480.
doi:10.1002/hipo.20986
apa: Ballesteros Merino, C., Lin, M., Wu, W., Ferrándiz Huertas, C., Cabañero, M.,
Watanabe, M., … Luján, R. (2012). Developmental profile of SK2 channel expression
and function in CA1 neurons. Hippocampus. Wiley-Blackwell. https://doi.org/10.1002/hipo.20986
chicago: Ballesteros Merino, Carmen, Michael Lin, Wendy Wu, Clotilde Ferrándiz Huertas,
María Cabañero, Masahiko Watanabe, Yugo Fukazawa, et al. “ Developmental Profile
of SK2 Channel Expression and Function in CA1 Neurons.” Hippocampus. Wiley-Blackwell,
2012. https://doi.org/10.1002/hipo.20986.
ieee: C. Ballesteros Merino et al., “ Developmental profile of SK2 channel
expression and function in CA1 neurons,” Hippocampus, vol. 22, no. 6. Wiley-Blackwell,
pp. 1467–1480, 2012.
ista: Ballesteros Merino C, Lin M, Wu W, Ferrándiz Huertas C, Cabañero M, Watanabe
M, Fukazawa Y, Shigemoto R, Maylie J, Adelman J, Luján R. 2012. Developmental
profile of SK2 channel expression and function in CA1 neurons. Hippocampus. 22(6),
1467–1480.
mla: Ballesteros Merino, Carmen, et al. “ Developmental Profile of SK2 Channel Expression
and Function in CA1 Neurons.” Hippocampus, vol. 22, no. 6, Wiley-Blackwell,
2012, pp. 1467–80, doi:10.1002/hipo.20986.
short: C. Ballesteros Merino, M. Lin, W. Wu, C. Ferrándiz Huertas, M. Cabañero,
M. Watanabe, Y. Fukazawa, R. Shigemoto, J. Maylie, J. Adelman, R. Luján, Hippocampus
22 (2012) 1467–1480.
date_created: 2018-12-11T11:58:07Z
date_published: 2012-06-01T00:00:00Z
date_updated: 2021-01-12T06:57:57Z
day: '01'
doi: 10.1002/hipo.20986
extern: 1
intvolume: ' 22'
issue: '6'
month: '06'
page: 1467 - 1480
publication: Hippocampus
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4386'
quality_controlled: 0
status: public
title: ' Developmental profile of SK2 channel expression and function in CA1 neurons'
type: journal_article
volume: 22
year: '2012'
...
---
_id: '1725'
abstract:
- lang: eng
text: The spatial organization of cell fates during development involves the interpretation
of morphogen gradients by cellular signaling cascades and transcriptional networks.
Recent studies use biophysical models, genetics, and quantitative imaging to unravel
how tissue-level morphogen behavior arises from subcellular events. Moreover,
data from several systems show that morphogen gradients, downstream signaling,
and the activity of cell-intrinsic transcriptional networks change dynamically
during pattern formation. Studies from Drosophila and now also vertebrates suggest
that transcriptional network dynamics are central to the generation of gene expression
patterns. Together, this leads to the view that pattern formation is an emergent
behavior that results from the coordination of events occurring across molecular,
cellular, and tissue scales. The development of novel approaches to study this
complex process remains a challenge.
acknowledgement: 'Funding provided by the Medical Research Council (UK). '
author:
- first_name: Anna
full_name: Anna Kicheva
id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
last_name: Kicheva
orcid: 0000-0003-4509-4998
- first_name: Michael
full_name: Cohen, Michael H
last_name: Cohen
- first_name: James
full_name: Briscoe, James
last_name: Briscoe
citation:
ama: 'Kicheva A, Cohen M, Briscoe J. Developmental pattern formation: Insights from
physics and biology. Science. 2012;338(6104):210-212. doi:10.1126/science.1225182'
apa: 'Kicheva, A., Cohen, M., & Briscoe, J. (2012). Developmental pattern formation:
Insights from physics and biology. Science. American Association for the
Advancement of Science. https://doi.org/10.1126/science.1225182'
chicago: 'Kicheva, Anna, Michael Cohen, and James Briscoe. “Developmental Pattern
Formation: Insights from Physics and Biology.” Science. American Association
for the Advancement of Science, 2012. https://doi.org/10.1126/science.1225182.'
ieee: 'A. Kicheva, M. Cohen, and J. Briscoe, “Developmental pattern formation: Insights
from physics and biology,” Science, vol. 338, no. 6104. American Association
for the Advancement of Science, pp. 210–212, 2012.'
ista: 'Kicheva A, Cohen M, Briscoe J. 2012. Developmental pattern formation: Insights
from physics and biology. Science. 338(6104), 210–212.'
mla: 'Kicheva, Anna, et al. “Developmental Pattern Formation: Insights from Physics
and Biology.” Science, vol. 338, no. 6104, American Association for the
Advancement of Science, 2012, pp. 210–12, doi:10.1126/science.1225182.'
short: A. Kicheva, M. Cohen, J. Briscoe, Science 338 (2012) 210–212.
date_created: 2018-12-11T11:53:40Z
date_published: 2012-10-12T00:00:00Z
date_updated: 2021-01-12T06:52:47Z
day: '12'
doi: 10.1126/science.1225182
extern: 1
intvolume: ' 338'
issue: '6104'
month: '10'
page: 210 - 212
publication: Science
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '5404'
quality_controlled: 0
status: public
title: 'Developmental pattern formation: Insights from physics and biology'
type: journal_article
volume: 338
year: '2012'
...
---
_id: '1756'
abstract:
- lang: eng
text: We report on the electronic transport properties of multiple-gate devices
fabricated from undoped silicon nanowires. Understanding and control of the relevant
transport mechanisms was achieved by means of local electrostatic gating and temperature-dependent
measurements. The roles of the source/drain contacts and of the silicon channel
could be independently evaluated and tuned. Wrap gates surrounding the silicide-silicon
contact interfaces were proved to be effective in inducing a full suppression
of the contact Schottky barriers, thereby enabling carrier injection down to liquid
helium temperature. By independently tuning the effective Schottky barrier heights,
a variety of reconfigurable device functionalities could be obtained. In particular,
the same nanowire device could be configured to work as a Schottky barrier transistor,
a Schottky diode, or a p-n diode with tunable polarities. This versatility was
eventually exploited to realize a NAND logic gate with gain well above one.
acknowledgement: This work was supported by the Agence Nationale de la Recherche (ANR)
through the ACCESS and COHESION projects and by the European Commission through
the Chemtronics program MEST-CT-2005-020513
author:
- first_name: Massimo
full_name: Mongillo, Massimo
last_name: Mongillo
- first_name: Panayotis
full_name: Spathis, Panayotis N
last_name: Spathis
- first_name: Georgios
full_name: Georgios Katsaros
id: 38DB5788-F248-11E8-B48F-1D18A9856A87
last_name: Katsaros
- first_name: Pascal
full_name: Gentile, Pascal
last_name: Gentile
- first_name: Silvano
full_name: De Franceschi, Silvano
last_name: De Franceschi
citation:
ama: Mongillo M, Spathis P, Katsaros G, Gentile P, De Franceschi S. Multifunctional
devices and logic gates with undoped silicon nanowires. Nano Letters. 2012;12(6):3074-3079.
doi:10.1021/nl300930m
apa: Mongillo, M., Spathis, P., Katsaros, G., Gentile, P., & De Franceschi,
S. (2012). Multifunctional devices and logic gates with undoped silicon nanowires.
Nano Letters. American Chemical Society. https://doi.org/10.1021/nl300930m
chicago: Mongillo, Massimo, Panayotis Spathis, Georgios Katsaros, Pascal Gentile,
and Silvano De Franceschi. “Multifunctional Devices and Logic Gates with Undoped
Silicon Nanowires.” Nano Letters. American Chemical Society, 2012. https://doi.org/10.1021/nl300930m.
ieee: M. Mongillo, P. Spathis, G. Katsaros, P. Gentile, and S. De Franceschi, “Multifunctional
devices and logic gates with undoped silicon nanowires,” Nano Letters,
vol. 12, no. 6. American Chemical Society, pp. 3074–3079, 2012.
ista: Mongillo M, Spathis P, Katsaros G, Gentile P, De Franceschi S. 2012. Multifunctional
devices and logic gates with undoped silicon nanowires. Nano Letters. 12(6), 3074–3079.
mla: Mongillo, Massimo, et al. “Multifunctional Devices and Logic Gates with Undoped
Silicon Nanowires.” Nano Letters, vol. 12, no. 6, American Chemical Society,
2012, pp. 3074–79, doi:10.1021/nl300930m.
short: M. Mongillo, P. Spathis, G. Katsaros, P. Gentile, S. De Franceschi, Nano
Letters 12 (2012) 3074–3079.
date_created: 2018-12-11T11:53:50Z
date_published: 2012-06-13T00:00:00Z
date_updated: 2021-01-12T06:53:00Z
day: '13'
doi: 10.1021/nl300930m
extern: 1
intvolume: ' 12'
issue: '6'
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/1208.1465
month: '06'
oa: 1
page: 3074 - 3079
publication: Nano Letters
publication_status: published
publisher: American Chemical Society
publist_id: '5368'
quality_controlled: 0
status: public
title: Multifunctional devices and logic gates with undoped silicon nanowires
type: journal_article
volume: 12
year: '2012'
...
---
_id: '1757'
abstract:
- lang: eng
text: Self-assembled Ge wires with a height of only 3 unit cells and a length of
up to 2 micrometers were grown on Si(001) by means of a catalyst-free method based
on molecular beam epitaxy. The wires grow horizontally along either the [100]
or the [010] direction. On atomically flat surfaces, they exhibit a highly uniform,
triangular cross section. A simple thermodynamic model accounts for the existence
of a preferential base width for longitudinal expansion, in quantitative agreement
with the experimental findings. Despite the absence of intentional doping, the
first transistor-type devices made from single wires show low-resistive electrical
contacts and single-hole transport at sub-Kelvin temperatures. In view of their
exceptionally small and self-defined cross section, these Ge wires hold promise
for the realization of hole systems with exotic properties and provide a new development
route for silicon-based nanoelectronics.
acknowledgement: We acknowledge the financial support by the DFG SPP1386, P. Chen
and D. J. Thurmer for MBE assistance, R. Wacquez for providing the ultrathin SOI
wafers, and G. Bauer, Y. Hu, X. Jehl, S. Kiravittaya, C. Klöffel, E. J. H. Lee,
F. Liu, D. Loss, and S. Mahapatra for helpful discussions. G. K. acknowledges support
from the European commission via a Marie Curie Carrer Integration Grant. S. D. F.
acknowledges support from the European Research Council through the starting grant
program
author:
- first_name: Jianjun
full_name: Zhang, Jianjun
last_name: Zhang
- first_name: Georgios
full_name: Georgios Katsaros
id: 38DB5788-F248-11E8-B48F-1D18A9856A87
last_name: Katsaros
- first_name: Francesco
full_name: Montalenti, Francesco
last_name: Montalenti
- first_name: Daniele
full_name: Scopece, Daniele
last_name: Scopece
- first_name: Roman
full_name: Rezaev, Roman O
last_name: Rezaev
- first_name: Christine
full_name: Mickel, Christine H
last_name: Mickel
- first_name: Bernd
full_name: Rellinghaus, Bernd
last_name: Rellinghaus
- first_name: Leo
full_name: Miglio, Leo P
last_name: Miglio
- first_name: Silvano
full_name: De Franceschi, Silvano
last_name: De Franceschi
- first_name: Armando
full_name: Rastelli, Armando
last_name: Rastelli
- first_name: Oliver
full_name: Schmidt, Oliver G
last_name: Schmidt
citation:
ama: Zhang J, Katsaros G, Montalenti F, et al. Monolithic growth of ultrathin Ge
nanowires on Si(001) . Physical Review Letters. 2012;109(8). doi:10.1103/PhysRevLett.109.085502
apa: Zhang, J., Katsaros, G., Montalenti, F., Scopece, D., Rezaev, R., Mickel, C.,
… Schmidt, O. (2012). Monolithic growth of ultrathin Ge nanowires on Si(001) .
Physical Review Letters. American Physical Society. https://doi.org/10.1103/PhysRevLett.109.085502
chicago: Zhang, Jianjun, Georgios Katsaros, Francesco Montalenti, Daniele Scopece,
Roman Rezaev, Christine Mickel, Bernd Rellinghaus, et al. “Monolithic Growth of
Ultrathin Ge Nanowires on Si(001) .” Physical Review Letters. American
Physical Society, 2012. https://doi.org/10.1103/PhysRevLett.109.085502.
ieee: J. Zhang et al., “Monolithic growth of ultrathin Ge nanowires on Si(001)
,” Physical Review Letters, vol. 109, no. 8. American Physical Society,
2012.
ista: Zhang J, Katsaros G, Montalenti F, Scopece D, Rezaev R, Mickel C, Rellinghaus
B, Miglio L, De Franceschi S, Rastelli A, Schmidt O. 2012. Monolithic growth of
ultrathin Ge nanowires on Si(001) . Physical Review Letters. 109(8).
mla: Zhang, Jianjun, et al. “Monolithic Growth of Ultrathin Ge Nanowires on Si(001)
.” Physical Review Letters, vol. 109, no. 8, American Physical Society,
2012, doi:10.1103/PhysRevLett.109.085502.
short: J. Zhang, G. Katsaros, F. Montalenti, D. Scopece, R. Rezaev, C. Mickel, B.
Rellinghaus, L. Miglio, S. De Franceschi, A. Rastelli, O. Schmidt, Physical Review
Letters 109 (2012).
date_created: 2018-12-11T11:53:51Z
date_published: 2012-08-23T00:00:00Z
date_updated: 2021-01-12T06:53:00Z
day: '23'
doi: 10.1103/PhysRevLett.109.085502
extern: 1
intvolume: ' 109'
issue: '8'
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/1208.0666
month: '08'
oa: 1
publication: Physical Review Letters
publication_status: published
publisher: American Physical Society
publist_id: '5367'
quality_controlled: 0
status: public
title: 'Monolithic growth of ultrathin Ge nanowires on Si(001) '
type: journal_article
volume: 109
year: '2012'
...
---
_id: '1758'
abstract:
- lang: eng
text: We studied the low-energy states of spin-1/2 quantum dots defined in InAs/InP
nanowires and coupled to aluminum superconducting leads. By varying the superconducting
gap Δ with a magnetic field B we investigated the transition from strong coupling
Δ≪T K to weak-coupling Δ≫T K, where T K is the Kondo temperature. Below the critical
field, we observe a persisting zero-bias Kondo resonance that vanishes only for
low B or higher temperatures, leaving the room to more robust subgap structures
at bias voltages between Δ and 2Δ. For strong and approximately symmetric tunnel
couplings, a Josephson supercurrent is observed in addition to the Kondo peak.
We ascribe the coexistence of a Kondo resonance and a superconducting gap to a
significant density of intragap quasiparticle states, and the finite-bias subgap
structures to tunneling through Shiba states. Our results, supported by numerical
calculations, own relevance also in relation to tunnel-spectroscopy experiments
aiming at the observation of Majorana fermions in hybrid nanostructures.
acknowledgement: This work was supported by the EU Marie Curie program and by the
Agence Nationale de la Recherche. R. A. acknowledges support from the Spanish Ministry
of Science and Innovation through Grant No. FIS2009-08744
author:
- first_name: Eduardo
full_name: Lee, Eduardo J
last_name: Lee
- first_name: Xiaocheng
full_name: Jiang, Xiaocheng
last_name: Jiang
- first_name: Ramón
full_name: Aguado, Ramón
last_name: Aguado
- first_name: Georgios
full_name: Georgios Katsaros
id: 38DB5788-F248-11E8-B48F-1D18A9856A87
last_name: Katsaros
- first_name: Charles
full_name: Lieber, Charles M
last_name: Lieber
- first_name: Silvano
full_name: De Franceschi, Silvano
last_name: De Franceschi
citation:
ama: Lee E, Jiang X, Aguado R, Katsaros G, Lieber C, De Franceschi S. Zero-bias
anomaly in a nanowire quantum dot coupled to superconductors. Physical Review
Letters. 2012;109(18). doi:10.1103/PhysRevLett.109.186802
apa: Lee, E., Jiang, X., Aguado, R., Katsaros, G., Lieber, C., & De Franceschi,
S. (2012). Zero-bias anomaly in a nanowire quantum dot coupled to superconductors.
Physical Review Letters. American Physical Society. https://doi.org/10.1103/PhysRevLett.109.186802
chicago: Lee, Eduardo, Xiaocheng Jiang, Ramón Aguado, Georgios Katsaros, Charles
Lieber, and Silvano De Franceschi. “Zero-Bias Anomaly in a Nanowire Quantum Dot
Coupled to Superconductors.” Physical Review Letters. American Physical
Society, 2012. https://doi.org/10.1103/PhysRevLett.109.186802.
ieee: E. Lee, X. Jiang, R. Aguado, G. Katsaros, C. Lieber, and S. De Franceschi,
“Zero-bias anomaly in a nanowire quantum dot coupled to superconductors,” Physical
Review Letters, vol. 109, no. 18. American Physical Society, 2012.
ista: Lee E, Jiang X, Aguado R, Katsaros G, Lieber C, De Franceschi S. 2012. Zero-bias
anomaly in a nanowire quantum dot coupled to superconductors. Physical Review
Letters. 109(18).
mla: Lee, Eduardo, et al. “Zero-Bias Anomaly in a Nanowire Quantum Dot Coupled to
Superconductors.” Physical Review Letters, vol. 109, no. 18, American Physical
Society, 2012, doi:10.1103/PhysRevLett.109.186802.
short: E. Lee, X. Jiang, R. Aguado, G. Katsaros, C. Lieber, S. De Franceschi, Physical
Review Letters 109 (2012).
date_created: 2018-12-11T11:53:51Z
date_published: 2012-10-31T00:00:00Z
date_updated: 2021-01-12T06:53:01Z
day: '31'
doi: 10.1103/PhysRevLett.109.186802
extern: 1
intvolume: ' 109'
issue: '18'
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/1207.1259
month: '10'
oa: 1
publication: Physical Review Letters
publication_status: published
publisher: American Physical Society
publist_id: '5366'
quality_controlled: 0
status: public
title: Zero-bias anomaly in a nanowire quantum dot coupled to superconductors
type: journal_article
volume: 109
year: '2012'
...
---
_id: '17613'
abstract:
- lang: eng
text: We study the interaction of a supermassive black hole (SMBH) binary and a
standard radiatively efficient thin accretion disk. We examine steady-state configurations
of the disk and migrating SMBH system, self-consistently accounting for tidal
and viscous torques and heating, radiative diffusion limited cooling, gas and
radiation pressure, and the decay of the binary's orbit. We obtain a "phase diagram"
of the system as a function of binary parameters, showing regimes in which both
the disk structure and migration have a different character. Although massive
binaries can create a central gap in the disk at large radii, the tidal barrier
of the secondary causes a significant pile-up of gas outside of its orbit, which
can lead to the closing of the gap. We find that this spillover occurs at an orbital
separation as large as ~200 M_7^{-1/2} gravitational radii, where M = 10^7 M_7
Msun is the total binary mass. If the secondary is less massive than ~10^6 Msun,
then the gap is closed before gravitational waves (GWs) start dominating the orbital
decay. In this regime, the disk is still strongly perturbed, but the piled-up
gas continuously overflows as in a porous dam, and crosses inside the secondary's
orbit. The corresponding migration rate, which we label Type 1.5, is slower than
the usual limiting cases known as Type I and II migration. Compared to an unperturbed
disk, the steady-state disk in the overflowing regime is up to several hundred
times brighter in the optical bands. Surveys such as PanSTARRS or LSST may discover
the periodic variability of this population of binaries. Our results imply that
the circumbinary disks around SMBHs can extend to small radii during the last
stages of their merger, when they are detectable by LISA, and may produce coincident
electromagnetic (EM) emission similar to active galactic nuclei (AGN).
alternative_title:
- 'Overflow and migration: SMBH binaries'
article_processing_charge: No
article_type: original
author:
- first_name: Bence
full_name: Kocsis, Bence
last_name: Kocsis
- first_name: Zoltán
full_name: Haiman, Zoltán
id: 7c006e8c-cc0d-11ee-8322-cb904ef76f36
last_name: Haiman
- first_name: Abraham
full_name: Loeb, Abraham
last_name: Loeb
citation:
ama: 'Kocsis B, Haiman Z, Loeb A. Gas pile-up, gap overflow and Type 1.5 migration
in circumbinary discs: Application to supermassive black hole binaries. Monthly
Notices of the Royal Astronomical Society. 2012;427(3):2680-2700. doi:10.1111/j.1365-2966.2012.22118.x'
apa: 'Kocsis, B., Haiman, Z., & Loeb, A. (2012). Gas pile-up, gap overflow and
Type 1.5 migration in circumbinary discs: Application to supermassive black hole
binaries. Monthly Notices of the Royal Astronomical Society. Oxford University
Press. https://doi.org/10.1111/j.1365-2966.2012.22118.x'
chicago: 'Kocsis, Bence, Zoltán Haiman, and Abraham Loeb. “Gas Pile-up, Gap Overflow
and Type 1.5 Migration in Circumbinary Discs: Application to Supermassive Black
Hole Binaries.” Monthly Notices of the Royal Astronomical Society. Oxford
University Press, 2012. https://doi.org/10.1111/j.1365-2966.2012.22118.x.'
ieee: 'B. Kocsis, Z. Haiman, and A. Loeb, “Gas pile-up, gap overflow and Type 1.5
migration in circumbinary discs: Application to supermassive black hole binaries,”
Monthly Notices of the Royal Astronomical Society, vol. 427, no. 3. Oxford
University Press, pp. 2680–2700, 2012.'
ista: 'Kocsis B, Haiman Z, Loeb A. 2012. Gas pile-up, gap overflow and Type 1.5
migration in circumbinary discs: Application to supermassive black hole binaries.
Monthly Notices of the Royal Astronomical Society. 427(3), 2680–2700.'
mla: 'Kocsis, Bence, et al. “Gas Pile-up, Gap Overflow and Type 1.5 Migration in
Circumbinary Discs: Application to Supermassive Black Hole Binaries.” Monthly
Notices of the Royal Astronomical Society, vol. 427, no. 3, Oxford University
Press, 2012, pp. 2680–700, doi:10.1111/j.1365-2966.2012.22118.x.'
short: B. Kocsis, Z. Haiman, A. Loeb, Monthly Notices of the Royal Astronomical
Society 427 (2012) 2680–2700.
date_created: 2024-09-05T13:28:17Z
date_published: 2012-12-11T00:00:00Z
date_updated: 2024-09-24T07:40:02Z
day: '11'
doi: 10.1111/j.1365-2966.2012.22118.x
extern: '1'
intvolume: ' 427'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1111/j.1365-2966.2012.22118.x
month: '12'
oa: 1
oa_version: Published Version
page: 2680-2700
publication: Monthly Notices of the Royal Astronomical Society
publication_identifier:
issn:
- 0035-8711
- 1365-2966
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Gas pile-up, gap overflow and Type 1.5 migration in circumbinary discs: Application
to supermassive black hole binaries'
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 427
year: '2012'
...
---
_id: '17636'
abstract:
- lang: eng
text: It is commonly believed that the earliest stages of star formation in the
Universe were self-regulated by global radiation backgrounds - either by the ultraviolet
(UV) Lyman-Werner (LW) photons emitted by the first stars (directly photodissociating
H2), or by the X-rays produced by accretion on to the black hole (BH) remnants
of these stars (heating the gas but catalysing H2 formation). Recent studies have
suggested that a significant fraction of the first stars may have had low masses
(a few M⊙). Such stars do not leave BH remnants and they have softer spectra,
with copious infrared (IR) radiation at photon energies ∼1 eV. Similar to LW and
X-ray photons, these photons have a mean-free path comparable to the Hubble distance,
building up an early IR background. Here we show that if soft-spectrum stars,
with masses of a few M⊙, contributed ≳0.3 per cent of the UV background (or their
mass fraction exceeded ∼80 per cent), then their IR radiation dominated radiative
feedback in the early Universe. The feedback is different from the UV feedback
from high-mass stars, and occurs through the photodetachment of H− ions, necessary
for efficient H2 formation. Nevertheless, we find that the baryon fraction which
must be incorporated into low-mass stars in order to suppress H2 cooling is only
a factor of a few higher than for high-mass stars.
article_processing_charge: No
article_type: original
author:
- first_name: J.
full_name: Wolcott-Green, J.
last_name: Wolcott-Green
- first_name: Zoltán
full_name: Haiman, Zoltán
id: 7c006e8c-cc0d-11ee-8322-cb904ef76f36
last_name: Haiman
citation:
ama: 'Wolcott-Green J, Haiman Z. Feedback from the infrared background in the early
universe. Monthly Notices of the Royal Astronomical Society: Letters. 2012;425(1):L51-L55.
doi:10.1111/j.1745-3933.2012.01298.x'
apa: 'Wolcott-Green, J., & Haiman, Z. (2012). Feedback from the infrared background
in the early universe. Monthly Notices of the Royal Astronomical Society: Letters.
Oxford University Press. https://doi.org/10.1111/j.1745-3933.2012.01298.x'
chicago: 'Wolcott-Green, J., and Zoltán Haiman. “Feedback from the Infrared Background
in the Early Universe.” Monthly Notices of the Royal Astronomical Society:
Letters. Oxford University Press, 2012. https://doi.org/10.1111/j.1745-3933.2012.01298.x.'
ieee: 'J. Wolcott-Green and Z. Haiman, “Feedback from the infrared background in
the early universe,” Monthly Notices of the Royal Astronomical Society: Letters,
vol. 425, no. 1. Oxford University Press, pp. L51–L55, 2012.'
ista: 'Wolcott-Green J, Haiman Z. 2012. Feedback from the infrared background in
the early universe. Monthly Notices of the Royal Astronomical Society: Letters.
425(1), L51–L55.'
mla: 'Wolcott-Green, J., and Zoltán Haiman. “Feedback from the Infrared Background
in the Early Universe.” Monthly Notices of the Royal Astronomical Society:
Letters, vol. 425, no. 1, Oxford University Press, 2012, pp. L51–55, doi:10.1111/j.1745-3933.2012.01298.x.'
short: 'J. Wolcott-Green, Z. Haiman, Monthly Notices of the Royal Astronomical Society:
Letters 425 (2012) L51–L55.'
date_created: 2024-09-06T07:07:07Z
date_published: 2012-09-01T00:00:00Z
date_updated: 2024-09-24T11:29:36Z
day: '01'
doi: 10.1111/j.1745-3933.2012.01298.x
extern: '1'
intvolume: ' 425'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1111/j.1745-3933.2012.01298.x
month: '09'
oa: 1
oa_version: Published Version
page: L51-L55
publication: 'Monthly Notices of the Royal Astronomical Society: Letters'
publication_identifier:
issn:
- 1745-3925
- 1745-3933
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Feedback from the infrared background in the early universe
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 425
year: '2012'
...