---
_id: '10748'
abstract:
- lang: eng
text: The study of fluxoid states and fluxoid dynamics in mesoscopic iron-based
superconducting rings is valuable for characterizing the basic properties of the
superconductor, and may also provide important insight into the superconducting
paring symmetry. We report the fabrications of micron-sized rings and disks from
thin films of Fe(Se, Te) grown by molecular beam epitaxy. In order to study fluxoid
states in rings we developed a custom-tailored version of magnetic force microscopy
(MFM). This technique has a number of qualitative advantages for working with
mesoscopic superconducting samples in comparison to the conventional MFM and other
imaging techniques. We observed metastable fluxoid states in rings of different
sizes. Thermally activated fluxoid dynamics of these states was studied and modeled.
In addition, we found different regimes of interaction between Fe(Se, Te) ring
and MFM tip which are explained. Possibilities of the existence of exotic vortex
states and proposals for experiments to test the symmetry of the superconducting
order parameter in iron based superconductors are analyzed.
alternative_title:
- Bulletin of the American Physical Society
article_number: G16.00009
article_processing_charge: No
author:
- first_name: Hryhoriy
full_name: Polshyn, Hryhoriy
id: edfc7cb1-526e-11ec-b05a-e6ecc27e4e48
last_name: Polshyn
orcid: 0000-0001-8223-8896
- first_name: Can
full_name: Zhang, Can
last_name: Zhang
- first_name: Tyler
full_name: Naibert, Tyler
last_name: Naibert
- first_name: James
full_name: Eckstein, James
last_name: Eckstein
- first_name: Raffi
full_name: Budakian, Raffi
last_name: Budakian
citation:
ama: 'Polshyn H, Zhang C, Naibert T, Eckstein J, Budakian R. Study of Fe (Se, Te)
micron-sized rings by magnetic force microscopy. In: APS March Meeting 2015.
Vol 60. American Physical Society; 2015.'
apa: 'Polshyn, H., Zhang, C., Naibert, T., Eckstein, J., & Budakian, R. (2015).
Study of Fe (Se, Te) micron-sized rings by magnetic force microscopy. In APS
March Meeting 2015 (Vol. 60). San Antonio, TX, United States: American Physical
Society.'
chicago: Polshyn, Hryhoriy, Can Zhang, Tyler Naibert, James Eckstein, and Raffi
Budakian. “Study of Fe (Se, Te) Micron-Sized Rings by Magnetic Force Microscopy.”
In APS March Meeting 2015, Vol. 60. American Physical Society, 2015.
ieee: H. Polshyn, C. Zhang, T. Naibert, J. Eckstein, and R. Budakian, “Study of
Fe (Se, Te) micron-sized rings by magnetic force microscopy,” in APS March
Meeting 2015, San Antonio, TX, United States, 2015, vol. 60, no. 1.
ista: 'Polshyn H, Zhang C, Naibert T, Eckstein J, Budakian R. 2015. Study of Fe
(Se, Te) micron-sized rings by magnetic force microscopy. APS March Meeting 2015.
APS: American Physical Society, Bulletin of the American Physical Society, vol.
60, G16.00009.'
mla: Polshyn, Hryhoriy, et al. “Study of Fe (Se, Te) Micron-Sized Rings by Magnetic
Force Microscopy.” APS March Meeting 2015, vol. 60, no. 1, G16.00009, American
Physical Society, 2015.
short: H. Polshyn, C. Zhang, T. Naibert, J. Eckstein, R. Budakian, in:, APS March
Meeting 2015, American Physical Society, 2015.
conference:
end_date: 2015-03-06
location: San Antonio, TX, United States
name: 'APS: American Physical Society'
start_date: 2015-03-02
date_created: 2022-02-08T10:17:09Z
date_published: 2015-03-01T00:00:00Z
date_updated: 2022-02-08T10:42:53Z
day: '01'
extern: '1'
intvolume: ' 60'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://meetings.aps.org/Meeting/MAR15/Event/238442
month: '03'
oa: 1
oa_version: Published Version
publication: APS March Meeting 2015
publication_identifier:
issn:
- 0003-0503
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
status: public
title: Study of Fe (Se, Te) micron-sized rings by magnetic force microscopy
type: conference
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 60
year: '2015'
...
---
_id: '10794'
abstract:
- lang: eng
text: Mathematical models are of fundamental importance in the understanding of
complex population dynamics. For instance, they can be used to predict the population
evolution starting from different initial conditions or to test how a system responds
to external perturbations. For this analysis to be meaningful in real applications,
however, it is of paramount importance to choose an appropriate model structure
and to infer the model parameters from measured data. While many parameter inference
methods are available for models based on deterministic ordinary differential
equations, the same does not hold for more detailed individual-based models. Here
we consider, in particular, stochastic models in which the time evolution of the
species abundances is described by a continuous-time Markov chain. These models
are governed by a master equation that is typically difficult to solve. Consequently,
traditional inference methods that rely on iterative evaluation of parameter likelihoods
are computationally intractable. The aim of this paper is to present recent advances
in parameter inference for continuous-time Markov chain models, based on a moment
closure approximation of the parameter likelihood, and to investigate how these
results can help in understanding, and ultimately controlling, complex systems
in ecology. Specifically, we illustrate through an agricultural pest case study
how parameters of a stochastic individual-based model can be identified from measured
data and how the resulting model can be used to solve an optimal control problem
in a stochastic setting. In particular, we show how the matter of determining
the optimal combination of two different pest control methods can be formulated
as a chance constrained optimization problem where the control action is modeled
as a state reset, leading to a hybrid system formulation.
acknowledgement: "The authors would like to acknowledge contributions from Baptiste
Mottet who performed preliminary analysis regarding parameter inference for the
considered case study in a student project (Mottet, 2014/2015).\r\nThe research
leading to these results has received funding from the People Programme (Marie Curie
Actions) of the European Union's Seventh Framework Programme (FP7/2007-2013) under
REA grant agreement No. [291734] and from SystemsX under the project SignalX."
article_number: '42'
article_processing_charge: No
article_type: original
author:
- first_name: Francesca
full_name: Parise, Francesca
last_name: Parise
- first_name: John
full_name: Lygeros, John
last_name: Lygeros
- first_name: Jakob
full_name: Ruess, Jakob
id: 4A245D00-F248-11E8-B48F-1D18A9856A87
last_name: Ruess
orcid: 0000-0003-1615-3282
citation:
ama: 'Parise F, Lygeros J, Ruess J. Bayesian inference for stochastic individual-based
models of ecological systems: a pest control simulation study. Frontiers in
Environmental Science. 2015;3. doi:10.3389/fenvs.2015.00042'
apa: 'Parise, F., Lygeros, J., & Ruess, J. (2015). Bayesian inference for stochastic
individual-based models of ecological systems: a pest control simulation study.
Frontiers in Environmental Science. Frontiers. https://doi.org/10.3389/fenvs.2015.00042'
chicago: 'Parise, Francesca, John Lygeros, and Jakob Ruess. “Bayesian Inference
for Stochastic Individual-Based Models of Ecological Systems: A Pest Control Simulation
Study.” Frontiers in Environmental Science. Frontiers, 2015. https://doi.org/10.3389/fenvs.2015.00042.'
ieee: 'F. Parise, J. Lygeros, and J. Ruess, “Bayesian inference for stochastic individual-based
models of ecological systems: a pest control simulation study,” Frontiers in
Environmental Science, vol. 3. Frontiers, 2015.'
ista: 'Parise F, Lygeros J, Ruess J. 2015. Bayesian inference for stochastic individual-based
models of ecological systems: a pest control simulation study. Frontiers in Environmental
Science. 3, 42.'
mla: 'Parise, Francesca, et al. “Bayesian Inference for Stochastic Individual-Based
Models of Ecological Systems: A Pest Control Simulation Study.” Frontiers in
Environmental Science, vol. 3, 42, Frontiers, 2015, doi:10.3389/fenvs.2015.00042.'
short: F. Parise, J. Lygeros, J. Ruess, Frontiers in Environmental Science 3 (2015).
date_created: 2022-02-25T11:42:25Z
date_published: 2015-06-10T00:00:00Z
date_updated: 2022-02-25T11:59:23Z
day: '10'
ddc:
- '000'
- '570'
department:
- _id: ToHe
- _id: GaTk
doi: 10.3389/fenvs.2015.00042
ec_funded: 1
file:
- access_level: open_access
checksum: 26c222487564e1be02a11d688d6f769d
content_type: application/pdf
creator: dernst
date_created: 2022-02-25T11:55:26Z
date_updated: 2022-02-25T11:55:26Z
file_id: '10795'
file_name: 2015_FrontiersEnvironmScience_Parise.pdf
file_size: 1371201
relation: main_file
success: 1
file_date_updated: 2022-02-25T11:55:26Z
has_accepted_license: '1'
intvolume: ' 3'
keyword:
- General Environmental Science
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication: Frontiers in Environmental Science
publication_identifier:
issn:
- 2296-665X
publication_status: published
publisher: Frontiers
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Bayesian inference for stochastic individual-based models of ecological systems:
a pest control simulation study'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 3
year: '2015'
...
---
_id: '10796'
abstract:
- lang: eng
text: 'We consider concurrent mean-payoff games, a very well-studied class of two-player
(player 1 vs player 2) zero-sum games on finite-state graphs where every transition
is assigned a reward between 0 and 1, and the payoff function is the long-run
average of the rewards. The value is the maximal expected payoff that player 1
can guarantee against all strategies of player 2. We consider the computation
of the set of states with value 1 under finite-memory strategies for player 1,
and our main results for the problem are as follows: (1) we present a polynomial-time
algorithm; (2) we show that whenever there is a finite-memory strategy, there
is a stationary strategy that does not need memory at all; and (3) we present
an optimal bound (which is double exponential) on the patience of stationary strategies
(where patience of a distribution is the inverse of the smallest positive probability
and represents a complexity measure of a stationary strategy).'
acknowledgement: "The research was partly supported by FWF Grant No P 23499-N23, FWF
NFN Grant\r\nNo S11407-N23 (RiSE), ERC Start grant (279307: Graph Games), and Microsoft
faculty fellows award."
article_processing_charge: No
author:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Rasmus
full_name: Ibsen-Jensen, Rasmus
id: 3B699956-F248-11E8-B48F-1D18A9856A87
last_name: Ibsen-Jensen
orcid: 0000-0003-4783-0389
citation:
ama: 'Chatterjee K, Ibsen-Jensen R. The value 1 problem under finite-memory strategies
for concurrent mean-payoff games. In: Proceedings of the Twenty-Sixth Annual
ACM-SIAM Symposium on Discrete Algorithms. Vol 2015. SIAM; 2015:1018-1029.
doi:10.1137/1.9781611973730.69'
apa: 'Chatterjee, K., & Ibsen-Jensen, R. (2015). The value 1 problem under finite-memory
strategies for concurrent mean-payoff games. In Proceedings of the Twenty-Sixth
Annual ACM-SIAM Symposium on Discrete Algorithms (Vol. 2015, pp. 1018–1029).
San Diego, CA, United States: SIAM. https://doi.org/10.1137/1.9781611973730.69'
chicago: Chatterjee, Krishnendu, and Rasmus Ibsen-Jensen. “The Value 1 Problem under
Finite-Memory Strategies for Concurrent Mean-Payoff Games.” In Proceedings
of the Twenty-Sixth Annual ACM-SIAM Symposium on Discrete Algorithms, 2015:1018–29.
SIAM, 2015. https://doi.org/10.1137/1.9781611973730.69.
ieee: K. Chatterjee and R. Ibsen-Jensen, “The value 1 problem under finite-memory
strategies for concurrent mean-payoff games,” in Proceedings of the Twenty-Sixth
Annual ACM-SIAM Symposium on Discrete Algorithms, San Diego, CA, United States,
2015, vol. 2015, no. 1, pp. 1018–1029.
ista: 'Chatterjee K, Ibsen-Jensen R. 2015. The value 1 problem under finite-memory
strategies for concurrent mean-payoff games. Proceedings of the Twenty-Sixth Annual
ACM-SIAM Symposium on Discrete Algorithms. SODA: Symposium on Discrete Algorithms
vol. 2015, 1018–1029.'
mla: Chatterjee, Krishnendu, and Rasmus Ibsen-Jensen. “The Value 1 Problem under
Finite-Memory Strategies for Concurrent Mean-Payoff Games.” Proceedings of
the Twenty-Sixth Annual ACM-SIAM Symposium on Discrete Algorithms, vol. 2015,
no. 1, SIAM, 2015, pp. 1018–29, doi:10.1137/1.9781611973730.69.
short: K. Chatterjee, R. Ibsen-Jensen, in:, Proceedings of the Twenty-Sixth Annual
ACM-SIAM Symposium on Discrete Algorithms, SIAM, 2015, pp. 1018–1029.
conference:
end_date: 2015-01-06
location: San Diego, CA, United States
name: 'SODA: Symposium on Discrete Algorithms'
start_date: 2015-01-04
date_created: 2022-02-25T12:18:43Z
date_published: 2015-01-01T00:00:00Z
date_updated: 2022-02-25T12:33:32Z
day: '01'
department:
- _id: KrCh
doi: 10.1137/1.9781611973730.69
ec_funded: 1
external_id:
arxiv:
- '1409.6690'
intvolume: ' 2015'
issue: '1'
language:
- iso: eng
month: '01'
oa_version: Preprint
page: 1018-1029
project:
- _id: 2584A770-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P 23499-N23
name: Modern Graph Algorithmic Techniques in Formal Verification
- _id: 25863FF4-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S11407
name: Game Theory
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '279307'
name: 'Quantitative Graph Games: Theory and Applications'
- _id: 2587B514-B435-11E9-9278-68D0E5697425
name: Microsoft Research Faculty Fellowship
publication: Proceedings of the Twenty-Sixth Annual ACM-SIAM Symposium on Discrete
Algorithms
publication_identifier:
isbn:
- 978-161197374-7
publication_status: published
publisher: SIAM
quality_controlled: '1'
scopus_import: '1'
status: public
title: The value 1 problem under finite-memory strategies for concurrent mean-payoff
games
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 2015
year: '2015'
...
---
_id: '1106'
abstract:
- lang: eng
text: Circumferential skin creases Kunze type (CSC-KT) is a specific congenital
entity with an unknown genetic cause. The disease phenotype comprises characteristic
circumferential skin creases accompanied by intellectual disability, a cleft palate,
short stature, and dysmorphic features. Here, we report that mutations in either
MAPRE2 or TUBB underlie the genetic origin of this syndrome. MAPRE2 encodes a
member of the microtubule end-binding family of proteins that bind to the guanosine
triphosphate cap at growing microtubule plus ends, and TUBB encodes a β-tubulin
isotype that is expressed abundantly in the developing brain. Functional analyses
of the TUBB mutants show multiple defects in the chaperone-dependent tubulin heterodimer
folding and assembly pathway that leads to a compromised yield of native heterodimers.
The TUBB mutations also have an impact on microtubule dynamics. For MAPRE2, we
show that the mutations result in enhanced MAPRE2 binding to microtubules, implying
an increased dwell time at microtubule plus ends. Further, in vivo analysis of
MAPRE2 mutations in a zebrafish model of craniofacial development shows that the
variants most likely perturb the patterning of branchial arches, either through
excessive activity (under a recessive paradigm) or through haploinsufficiency
(dominant de novo paradigm). Taken together, our data add CSC-KT to the growing
list of tubulinopathies and highlight how multiple inheritance paradigms can affect
dosage-sensitive biological systems so as to result in the same clinical defect.
author:
- first_name: Mala
full_name: Isrie, Mala
last_name: Isrie
- first_name: Martin
full_name: Breuss, Martin
last_name: Breuss
- first_name: Guoling
full_name: Tian, Guoling
last_name: Tian
- first_name: Andi H
full_name: Hansen, Andi H
id: 38853E16-F248-11E8-B48F-1D18A9856A87
last_name: Hansen
- first_name: Francesca
full_name: Cristofoli, Francesca
last_name: Cristofoli
- first_name: Jasmin
full_name: Morandell, Jasmin
id: 4739D480-F248-11E8-B48F-1D18A9856A87
last_name: Morandell
- first_name: Zachari A
full_name: Kupchinsky, Zachari A
last_name: Kupchinsky
- first_name: Alejandro
full_name: Sifrim, Alejandro
last_name: Sifrim
- first_name: Celia
full_name: Rodriguez Rodriguez, Celia
last_name: Rodriguez Rodriguez
- first_name: Elena P
full_name: Dapena, Elena P
last_name: Dapena
- first_name: Kurston
full_name: Doonanco, Kurston
last_name: Doonanco
- first_name: Norma
full_name: Leonard, Norma
last_name: Leonard
- first_name: Faten
full_name: Tinsa, Faten
last_name: Tinsa
- first_name: Stéphanie
full_name: Moortgat, Stéphanie
last_name: Moortgat
- first_name: Hakan
full_name: Ulucan, Hakan
last_name: Ulucan
- first_name: Erkan
full_name: Koparir, Erkan
last_name: Koparir
- first_name: Ender
full_name: Karaca, Ender
last_name: Karaca
- first_name: Nicholas
full_name: Katsanis, Nicholas
last_name: Katsanis
- first_name: Valeria
full_name: Marton, Valeria
last_name: Marton
- first_name: Joris R
full_name: Vermeesch, Joris R
last_name: Vermeesch
- first_name: Erica E
full_name: Davis, Erica E
last_name: Davis
- first_name: Nicholas J
full_name: Cowan, Nicholas J
last_name: Cowan
- first_name: David
full_name: Keays, David
last_name: Keays
- first_name: Hilde
full_name: Van Esch, Hilde
last_name: Van Esch
citation:
ama: Isrie M, Breuss M, Tian G, et al. Mutations in either TUBB or MAPRE2 cause
circumferential skin creases Kunze type. The American Journal of Human Genetics.
2015;97(6):790-800. doi:10.1016/j.ajhg.2015.10.014
apa: Isrie, M., Breuss, M., Tian, G., Hansen, A. H., Cristofoli, F., Morandell,
J., … Van Esch, H. (2015). Mutations in either TUBB or MAPRE2 cause circumferential
skin creases Kunze type. The American Journal of Human Genetics. Cell Press.
https://doi.org/10.1016/j.ajhg.2015.10.014
chicago: Isrie, Mala, Martin Breuss, Guoling Tian, Andi H Hansen, Francesca Cristofoli,
Jasmin Morandell, Zachari A Kupchinsky, et al. “Mutations in Either TUBB or MAPRE2
Cause Circumferential Skin Creases Kunze Type.” The American Journal of Human
Genetics. Cell Press, 2015. https://doi.org/10.1016/j.ajhg.2015.10.014.
ieee: M. Isrie et al., “Mutations in either TUBB or MAPRE2 cause circumferential
skin creases Kunze type,” The American Journal of Human Genetics, vol.
97, no. 6. Cell Press, pp. 790–800, 2015.
ista: Isrie M, Breuss M, Tian G, Hansen AH, Cristofoli F, Morandell J, Kupchinsky
ZA, Sifrim A, Rodriguez Rodriguez C, Dapena EP, Doonanco K, Leonard N, Tinsa F,
Moortgat S, Ulucan H, Koparir E, Karaca E, Katsanis N, Marton V, Vermeesch JR,
Davis EE, Cowan NJ, Keays D, Van Esch H. 2015. Mutations in either TUBB or MAPRE2
cause circumferential skin creases Kunze type. The American Journal of Human Genetics.
97(6), 790–800.
mla: Isrie, Mala, et al. “Mutations in Either TUBB or MAPRE2 Cause Circumferential
Skin Creases Kunze Type.” The American Journal of Human Genetics, vol.
97, no. 6, Cell Press, 2015, pp. 790–800, doi:10.1016/j.ajhg.2015.10.014.
short: M. Isrie, M. Breuss, G. Tian, A.H. Hansen, F. Cristofoli, J. Morandell, Z.A.
Kupchinsky, A. Sifrim, C. Rodriguez Rodriguez, E.P. Dapena, K. Doonanco, N. Leonard,
F. Tinsa, S. Moortgat, H. Ulucan, E. Koparir, E. Karaca, N. Katsanis, V. Marton,
J.R. Vermeesch, E.E. Davis, N.J. Cowan, D. Keays, H. Van Esch, The American Journal
of Human Genetics 97 (2015) 790–800.
date_created: 2018-12-11T11:50:11Z
date_published: 2015-12-03T00:00:00Z
date_updated: 2021-01-12T06:48:19Z
day: '03'
doi: 10.1016/j.ajhg.2015.10.014
extern: '1'
intvolume: ' 97'
issue: '6'
language:
- iso: eng
month: '12'
oa_version: None
page: 790 - 800
publication: The American Journal of Human Genetics
publication_status: published
publisher: Cell Press
publist_id: '6264'
quality_controlled: '1'
status: public
title: Mutations in either TUBB or MAPRE2 cause circumferential skin creases Kunze
type
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 97
year: '2015'
...
---
_id: '11079'
abstract:
- lang: eng
text: Aging is a major risk factor for many human diseases, and in vitro generation
of human neurons is an attractive approach for modeling aging-related brain disorders.
However, modeling aging in differentiated human neurons has proved challenging.
We generated neurons from human donors across a broad range of ages, either by
iPSC-based reprogramming and differentiation or by direct conversion into induced
neurons (iNs). While iPSCs and derived neurons did not retain aging-associated
gene signatures, iNs displayed age-specific transcriptional profiles and revealed
age-associated decreases in the nuclear transport receptor RanBP17. We detected
an age-dependent loss of nucleocytoplasmic compartmentalization (NCC) in donor
fibroblasts and corresponding iNs and found that reduced RanBP17 impaired NCC
in young cells, while iPSC rejuvenation restored NCC in aged cells. These results
show that iNs retain important aging-related signatures, thus allowing modeling
of the aging process in vitro, and they identify impaired NCC as an important
factor in human aging.
article_processing_charge: No
article_type: original
author:
- first_name: Jerome
full_name: Mertens, Jerome
last_name: Mertens
- first_name: Apuã C.M.
full_name: Paquola, Apuã C.M.
last_name: Paquola
- first_name: Manching
full_name: Ku, Manching
last_name: Ku
- first_name: Emily
full_name: Hatch, Emily
last_name: Hatch
- first_name: Lena
full_name: Böhnke, Lena
last_name: Böhnke
- first_name: Shauheen
full_name: Ladjevardi, Shauheen
last_name: Ladjevardi
- first_name: Sean
full_name: McGrath, Sean
last_name: McGrath
- first_name: Benjamin
full_name: Campbell, Benjamin
last_name: Campbell
- first_name: Hyungjun
full_name: Lee, Hyungjun
last_name: Lee
- first_name: Joseph R.
full_name: Herdy, Joseph R.
last_name: Herdy
- first_name: J. Tiago
full_name: Gonçalves, J. Tiago
last_name: Gonçalves
- first_name: Tomohisa
full_name: Toda, Tomohisa
last_name: Toda
- first_name: Yongsung
full_name: Kim, Yongsung
last_name: Kim
- first_name: Jürgen
full_name: Winkler, Jürgen
last_name: Winkler
- first_name: Jun
full_name: Yao, Jun
last_name: Yao
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
- first_name: Fred H.
full_name: Gage, Fred H.
last_name: Gage
citation:
ama: Mertens J, Paquola ACM, Ku M, et al. Directly reprogrammed human neurons retain
aging-associated transcriptomic signatures and reveal age-related nucleocytoplasmic
defects. Cell Stem Cell. 2015;17(6):705-718. doi:10.1016/j.stem.2015.09.001
apa: Mertens, J., Paquola, A. C. M., Ku, M., Hatch, E., Böhnke, L., Ladjevardi,
S., … Gage, F. H. (2015). Directly reprogrammed human neurons retain aging-associated
transcriptomic signatures and reveal age-related nucleocytoplasmic defects. Cell
Stem Cell. Elsevier. https://doi.org/10.1016/j.stem.2015.09.001
chicago: Mertens, Jerome, Apuã C.M. Paquola, Manching Ku, Emily Hatch, Lena Böhnke,
Shauheen Ladjevardi, Sean McGrath, et al. “Directly Reprogrammed Human Neurons
Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic
Defects.” Cell Stem Cell. Elsevier, 2015. https://doi.org/10.1016/j.stem.2015.09.001.
ieee: J. Mertens et al., “Directly reprogrammed human neurons retain aging-associated
transcriptomic signatures and reveal age-related nucleocytoplasmic defects,” Cell
Stem Cell, vol. 17, no. 6. Elsevier, pp. 705–718, 2015.
ista: Mertens J, Paquola ACM, Ku M, Hatch E, Böhnke L, Ladjevardi S, McGrath S,
Campbell B, Lee H, Herdy JR, Gonçalves JT, Toda T, Kim Y, Winkler J, Yao J, Hetzer
M, Gage FH. 2015. Directly reprogrammed human neurons retain aging-associated
transcriptomic signatures and reveal age-related nucleocytoplasmic defects. Cell
Stem Cell. 17(6), 705–718.
mla: Mertens, Jerome, et al. “Directly Reprogrammed Human Neurons Retain Aging-Associated
Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects.” Cell
Stem Cell, vol. 17, no. 6, Elsevier, 2015, pp. 705–18, doi:10.1016/j.stem.2015.09.001.
short: J. Mertens, A.C.M. Paquola, M. Ku, E. Hatch, L. Böhnke, S. Ladjevardi, S.
McGrath, B. Campbell, H. Lee, J.R. Herdy, J.T. Gonçalves, T. Toda, Y. Kim, J.
Winkler, J. Yao, M. Hetzer, F.H. Gage, Cell Stem Cell 17 (2015) 705–718.
date_created: 2022-04-07T07:49:51Z
date_published: 2015-12-03T00:00:00Z
date_updated: 2022-07-18T08:44:21Z
day: '03'
doi: 10.1016/j.stem.2015.09.001
extern: '1'
external_id:
pmid:
- '26456686'
intvolume: ' 17'
issue: '6'
keyword:
- Cell Biology
- Genetics
- Molecular Medicine
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.stem.2015.09.001
month: '12'
oa: 1
oa_version: Published Version
page: 705-718
pmid: 1
publication: Cell Stem Cell
publication_identifier:
issn:
- 1934-5909
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Directly reprogrammed human neurons retain aging-associated transcriptomic
signatures and reveal age-related nucleocytoplasmic defects
type: journal_article
user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd
volume: 17
year: '2015'
...
---
_id: '11077'
abstract:
- lang: eng
text: Nucleoporins (Nups) are a family of proteins best known as the constituent
building blocks of nuclear pore complexes (NPCs), membrane-embedded channels that
mediate nuclear transport across the nuclear envelope. Recent evidence suggests
that several Nups have additional roles in controlling the activation and silencing
of developmental genes; however, the mechanistic details of these functions remain
poorly understood. Here, we show that depletion of Nup153 in mouse embryonic stem
cells (mESCs) causes the derepression of developmental genes and induction of
early differentiation. This loss of stem cell identity is not associated with
defects in the nuclear import of key pluripotency factors. Rather, Nup153 binds
around the transcriptional start site (TSS) of developmental genes and mediates
the recruitment of the polycomb-repressive complex 1 (PRC1) to a subset of its
target loci. Our results demonstrate a chromatin-associated role of Nup153 in
maintaining stem cell pluripotency by functioning in mammalian epigenetic gene
silencing.
article_processing_charge: No
article_type: original
author:
- first_name: Filipe V.
full_name: Jacinto, Filipe V.
last_name: Jacinto
- first_name: Chris
full_name: Benner, Chris
last_name: Benner
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
citation:
ama: Jacinto FV, Benner C, Hetzer M. The nucleoporin Nup153 regulates embryonic
stem cell pluripotency through gene silencing. Genes & Development.
2015;29(12):1224-1238. doi:10.1101/gad.260919.115
apa: Jacinto, F. V., Benner, C., & Hetzer, M. (2015). The nucleoporin Nup153
regulates embryonic stem cell pluripotency through gene silencing. Genes &
Development. Cold Spring Harbor Laboratory. https://doi.org/10.1101/gad.260919.115
chicago: Jacinto, Filipe V., Chris Benner, and Martin Hetzer. “The Nucleoporin Nup153
Regulates Embryonic Stem Cell Pluripotency through Gene Silencing.” Genes &
Development. Cold Spring Harbor Laboratory, 2015. https://doi.org/10.1101/gad.260919.115.
ieee: F. V. Jacinto, C. Benner, and M. Hetzer, “The nucleoporin Nup153 regulates
embryonic stem cell pluripotency through gene silencing,” Genes & Development,
vol. 29, no. 12. Cold Spring Harbor Laboratory, pp. 1224–1238, 2015.
ista: Jacinto FV, Benner C, Hetzer M. 2015. The nucleoporin Nup153 regulates embryonic
stem cell pluripotency through gene silencing. Genes & Development. 29(12),
1224–1238.
mla: Jacinto, Filipe V., et al. “The Nucleoporin Nup153 Regulates Embryonic Stem
Cell Pluripotency through Gene Silencing.” Genes & Development, vol.
29, no. 12, Cold Spring Harbor Laboratory, 2015, pp. 1224–38, doi:10.1101/gad.260919.115.
short: F.V. Jacinto, C. Benner, M. Hetzer, Genes & Development 29 (2015) 1224–1238.
date_created: 2022-04-07T07:49:31Z
date_published: 2015-06-16T00:00:00Z
date_updated: 2022-07-18T08:43:51Z
day: '16'
doi: 10.1101/gad.260919.115
extern: '1'
external_id:
pmid:
- '26080816'
intvolume: ' 29'
issue: '12'
keyword:
- Developmental Biology
- Genetics
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/gad.260919.115
month: '06'
oa: 1
oa_version: Published Version
page: 1224-1238
pmid: 1
publication: Genes & Development
publication_identifier:
eissn:
- 1549-5477
issn:
- 0890-9369
publication_status: published
publisher: Cold Spring Harbor Laboratory
quality_controlled: '1'
scopus_import: '1'
status: public
title: The nucleoporin Nup153 regulates embryonic stem cell pluripotency through gene
silencing
type: journal_article
user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd
volume: 29
year: '2015'
...
---
_id: '11078'
abstract:
- lang: eng
text: Aging is associated with the decline of protein, cell, and organ function.
Here, we use an integrated approach to characterize gene expression, bulk translation,
and cell biology in the brains and livers of young and old rats. We identify 468
differences in protein abundance between young and old animals. The majority are
a consequence of altered translation output, that is, the combined effect of changes
in transcript abundance and translation efficiency. In addition, we identify 130
proteins whose overall abundance remains unchanged but whose sub-cellular localization,
phosphorylation state, or splice-form varies. While some protein-level differences
appear to be a generic property of the rats’ chronological age, the majority are
specific to one organ. These may be a consequence of the organ’s physiology or
the chronological age of the cells within the tissue. Taken together, our study
provides an initial view of the proteome at the molecular, sub-cellular, and organ
level in young and old rats.
article_processing_charge: No
article_type: original
author:
- first_name: Alessandro
full_name: Ori, Alessandro
last_name: Ori
- first_name: Brandon H.
full_name: Toyama, Brandon H.
last_name: Toyama
- first_name: Michael S.
full_name: Harris, Michael S.
last_name: Harris
- first_name: Thomas
full_name: Bock, Thomas
last_name: Bock
- first_name: Murat
full_name: Iskar, Murat
last_name: Iskar
- first_name: Peer
full_name: Bork, Peer
last_name: Bork
- first_name: Nicholas T.
full_name: Ingolia, Nicholas T.
last_name: Ingolia
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
- first_name: Martin
full_name: Beck, Martin
last_name: Beck
citation:
ama: Ori A, Toyama BH, Harris MS, et al. Integrated transcriptome and proteome analyses
reveal organ-specific proteome deterioration in old rats. Cell Systems.
2015;1(3):P224-237. doi:10.1016/j.cels.2015.08.012
apa: Ori, A., Toyama, B. H., Harris, M. S., Bock, T., Iskar, M., Bork, P., … Beck,
M. (2015). Integrated transcriptome and proteome analyses reveal organ-specific
proteome deterioration in old rats. Cell Systems. Elsevier. https://doi.org/10.1016/j.cels.2015.08.012
chicago: Ori, Alessandro, Brandon H. Toyama, Michael S. Harris, Thomas Bock, Murat
Iskar, Peer Bork, Nicholas T. Ingolia, Martin Hetzer, and Martin Beck. “Integrated
Transcriptome and Proteome Analyses Reveal Organ-Specific Proteome Deterioration
in Old Rats.” Cell Systems. Elsevier, 2015. https://doi.org/10.1016/j.cels.2015.08.012.
ieee: A. Ori et al., “Integrated transcriptome and proteome analyses reveal
organ-specific proteome deterioration in old rats,” Cell Systems, vol.
1, no. 3. Elsevier, pp. P224-237, 2015.
ista: Ori A, Toyama BH, Harris MS, Bock T, Iskar M, Bork P, Ingolia NT, Hetzer M,
Beck M. 2015. Integrated transcriptome and proteome analyses reveal organ-specific
proteome deterioration in old rats. Cell Systems. 1(3), P224-237.
mla: Ori, Alessandro, et al. “Integrated Transcriptome and Proteome Analyses Reveal
Organ-Specific Proteome Deterioration in Old Rats.” Cell Systems, vol.
1, no. 3, Elsevier, 2015, pp. P224-237, doi:10.1016/j.cels.2015.08.012.
short: A. Ori, B.H. Toyama, M.S. Harris, T. Bock, M. Iskar, P. Bork, N.T. Ingolia,
M. Hetzer, M. Beck, Cell Systems 1 (2015) P224-237.
date_created: 2022-04-07T07:49:39Z
date_published: 2015-09-23T00:00:00Z
date_updated: 2022-07-18T08:44:07Z
day: '23'
doi: 10.1016/j.cels.2015.08.012
extern: '1'
external_id:
pmid:
- '27135913'
intvolume: ' 1'
issue: '3'
keyword:
- Cell Biology
- Histology
- Pathology and Forensic Medicine
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.cels.2015.08.012
month: '09'
oa: 1
oa_version: Published Version
page: P224-237
pmid: 1
publication: Cell Systems
publication_identifier:
issn:
- 2405-4712
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Integrated transcriptome and proteome analyses reveal organ-specific proteome
deterioration in old rats
type: journal_article
user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd
volume: 1
year: '2015'
...
---
_id: '11075'
abstract:
- lang: eng
text: Previously, we identified the nucleoporin gp210/Nup210 as a critical regulator
of muscle and neuronal differentiation, but how this nucleoporin exerts its function
and whether it modulates nuclear pore complex (NPC) activity remain unknown. Here,
we show that gp210/Nup210 mediates muscle cell differentiation in vitro via its
conserved N-terminal domain that extends into the perinuclear space. Removal of
the C-terminal domain, which partially mislocalizes gp210/Nup210 away from NPCs,
efficiently rescues the differentiation defect caused by the knockdown of endogenous
gp210/Nup210. Unexpectedly, a gp210/Nup210 mutant lacking the NPC-targeting transmembrane
and C-terminal domains is sufficient for C2C12 myoblast differentiation. We demonstrate
that the endoplasmic reticulum (ER) stress-specific caspase cascade is exacerbated
during Nup210 depletion and that blocking ER stress-mediated apoptosis rescues
differentiation of Nup210-deficient cells. Our results suggest that the role of
gp210/Nup210 in cell differentiation is mediated by its large luminal domain,
which can act independently of NPC association and appears to play a pivotal role
in the maintenance of nuclear envelope/ER homeostasis.
article_processing_charge: No
article_type: original
author:
- first_name: J. Sebastian
full_name: Gomez-Cavazos, J. Sebastian
last_name: Gomez-Cavazos
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
citation:
ama: Gomez-Cavazos JS, Hetzer M. The nucleoporin gp210/Nup210 controls muscle differentiation
by regulating nuclear envelope/ER homeostasis. Journal of Cell Biology.
2015;208(6):671-681. doi:10.1083/jcb.201410047
apa: Gomez-Cavazos, J. S., & Hetzer, M. (2015). The nucleoporin gp210/Nup210
controls muscle differentiation by regulating nuclear envelope/ER homeostasis.
Journal of Cell Biology. Rockefeller University Press. https://doi.org/10.1083/jcb.201410047
chicago: Gomez-Cavazos, J. Sebastian, and Martin Hetzer. “The Nucleoporin Gp210/Nup210
Controls Muscle Differentiation by Regulating Nuclear Envelope/ER Homeostasis.”
Journal of Cell Biology. Rockefeller University Press, 2015. https://doi.org/10.1083/jcb.201410047.
ieee: J. S. Gomez-Cavazos and M. Hetzer, “The nucleoporin gp210/Nup210 controls
muscle differentiation by regulating nuclear envelope/ER homeostasis,” Journal
of Cell Biology, vol. 208, no. 6. Rockefeller University Press, pp. 671–681,
2015.
ista: Gomez-Cavazos JS, Hetzer M. 2015. The nucleoporin gp210/Nup210 controls muscle
differentiation by regulating nuclear envelope/ER homeostasis. Journal of Cell
Biology. 208(6), 671–681.
mla: Gomez-Cavazos, J. Sebastian, and Martin Hetzer. “The Nucleoporin Gp210/Nup210
Controls Muscle Differentiation by Regulating Nuclear Envelope/ER Homeostasis.”
Journal of Cell Biology, vol. 208, no. 6, Rockefeller University Press,
2015, pp. 671–81, doi:10.1083/jcb.201410047.
short: J.S. Gomez-Cavazos, M. Hetzer, Journal of Cell Biology 208 (2015) 671–681.
date_created: 2022-04-07T07:49:10Z
date_published: 2015-03-16T00:00:00Z
date_updated: 2022-07-18T08:43:00Z
day: '16'
doi: 10.1083/jcb.201410047
extern: '1'
external_id:
pmid:
- '25778917'
intvolume: ' 208'
issue: '6'
keyword:
- Cell Biology
language:
- iso: eng
month: '03'
oa_version: Published Version
page: 671-681
pmid: 1
publication: Journal of Cell Biology
publication_identifier:
eissn:
- 1540-8140
issn:
- 0021-9525
publication_status: published
publisher: Rockefeller University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: The nucleoporin gp210/Nup210 controls muscle differentiation by regulating
nuclear envelope/ER homeostasis
type: journal_article
user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd
volume: 208
year: '2015'
...
---
_id: '11076'
abstract:
- lang: eng
text: Nuclear pore complexes (NPCs) are composed of several copies of ∼30 different
proteins called nucleoporins (Nups). NPCs penetrate the nuclear envelope (NE)
and regulate the nucleocytoplasmic trafficking of macromolecules. Beyond this
vital role, NPC components influence genome functions in a transport-independent
manner. Nups play an evolutionarily conserved role in gene expression regulation
that, in metazoans, extends into the nuclear interior. Additionally, in proliferative
cells, Nups play a crucial role in genome integrity maintenance and mitotic progression.
Here we discuss genome-related functions of Nups and their impact on essential
DNA metabolism processes such as transcription, chromosome duplication, and segregation.
article_processing_charge: No
article_type: original
author:
- first_name: Arkaitz
full_name: Ibarra, Arkaitz
last_name: Ibarra
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
citation:
ama: Ibarra A, Hetzer M. Nuclear pore proteins and the control of genome functions.
Genes & Development. 2015;29(4):337-349. doi:10.1101/gad.256495.114
apa: Ibarra, A., & Hetzer, M. (2015). Nuclear pore proteins and the control
of genome functions. Genes & Development. Cold Spring Harbor Laboratory.
https://doi.org/10.1101/gad.256495.114
chicago: Ibarra, Arkaitz, and Martin Hetzer. “Nuclear Pore Proteins and the Control
of Genome Functions.” Genes & Development. Cold Spring Harbor Laboratory,
2015. https://doi.org/10.1101/gad.256495.114.
ieee: A. Ibarra and M. Hetzer, “Nuclear pore proteins and the control of genome
functions,” Genes & Development, vol. 29, no. 4. Cold Spring Harbor
Laboratory, pp. 337–349, 2015.
ista: Ibarra A, Hetzer M. 2015. Nuclear pore proteins and the control of genome
functions. Genes & Development. 29(4), 337–349.
mla: Ibarra, Arkaitz, and Martin Hetzer. “Nuclear Pore Proteins and the Control
of Genome Functions.” Genes & Development, vol. 29, no. 4, Cold Spring
Harbor Laboratory, 2015, pp. 337–49, doi:10.1101/gad.256495.114.
short: A. Ibarra, M. Hetzer, Genes & Development 29 (2015) 337–349.
date_created: 2022-04-07T07:49:21Z
date_published: 2015-02-01T00:00:00Z
date_updated: 2022-07-18T08:43:20Z
day: '01'
doi: 10.1101/gad.256495.114
extern: '1'
external_id:
pmid:
- '25691464'
intvolume: ' 29'
issue: '4'
keyword:
- Developmental Biology
- Genetics
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/gad.256495.114
month: '02'
oa: 1
oa_version: Published Version
page: 337-349
pmid: 1
publication: Genes & Development
publication_identifier:
eissn:
- 1549-5477
issn:
- 0890-9369
publication_status: published
publisher: Cold Spring Harbor Laboratory
quality_controlled: '1'
scopus_import: '1'
status: public
title: Nuclear pore proteins and the control of genome functions
type: journal_article
user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd
volume: 29
year: '2015'
...
---
_id: '11073'
abstract:
- lang: eng
text: Human cancer cells bear complex chromosome rearrangements that can be potential
drivers of cancer development. However, the molecular mechanisms underlying these
rearrangements have been unclear. Zhang et al. use a new technique combining live-cell
imaging and single-cell sequencing to demonstrate that chromosomes mis-segregated
to micronuclei frequently undergo chromothripsis-like rearrangements in the subsequent
cell cycle.
article_processing_charge: No
article_type: original
author:
- first_name: Emily M.
full_name: Hatch, Emily M.
last_name: Hatch
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
citation:
ama: Hatch EM, Hetzer M. Linking micronuclei to chromosome fragmentation. Cell.
2015;161(7):1502-1504. doi:10.1016/j.cell.2015.06.005
apa: Hatch, E. M., & Hetzer, M. (2015). Linking micronuclei to chromosome fragmentation.
Cell. Elsevier. https://doi.org/10.1016/j.cell.2015.06.005
chicago: Hatch, Emily M., and Martin Hetzer. “Linking Micronuclei to Chromosome
Fragmentation.” Cell. Elsevier, 2015. https://doi.org/10.1016/j.cell.2015.06.005.
ieee: E. M. Hatch and M. Hetzer, “Linking micronuclei to chromosome fragmentation,”
Cell, vol. 161, no. 7. Elsevier, pp. 1502–1504, 2015.
ista: Hatch EM, Hetzer M. 2015. Linking micronuclei to chromosome fragmentation.
Cell. 161(7), 1502–1504.
mla: Hatch, Emily M., and Martin Hetzer. “Linking Micronuclei to Chromosome Fragmentation.”
Cell, vol. 161, no. 7, Elsevier, 2015, pp. 1502–04, doi:10.1016/j.cell.2015.06.005.
short: E.M. Hatch, M. Hetzer, Cell 161 (2015) 1502–1504.
date_created: 2022-04-07T07:48:49Z
date_published: 2015-06-18T00:00:00Z
date_updated: 2022-07-18T08:34:33Z
day: '18'
doi: 10.1016/j.cell.2015.06.005
extern: '1'
external_id:
pmid:
- '26091034'
intvolume: ' 161'
issue: '7'
keyword:
- General Biochemistry
- Genetics and Molecular Biology
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.cell.2015.06.005
month: '06'
oa: 1
oa_version: Published Version
page: 1502-1504
pmid: 1
publication: Cell
publication_identifier:
issn:
- 0092-8674
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Linking micronuclei to chromosome fragmentation
type: journal_article
user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd
volume: 161
year: '2015'
...
---
_id: '11074'
article_processing_charge: No
article_type: original
author:
- first_name: Emily M.
full_name: Hatch, Emily M.
last_name: Hatch
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
citation:
ama: Hatch EM, Hetzer M. Chromothripsis. Current Biology. 2015;25(10):PR397-R399.
doi:10.1016/j.cub.2015.02.033
apa: Hatch, E. M., & Hetzer, M. (2015). Chromothripsis. Current Biology.
Elsevier. https://doi.org/10.1016/j.cub.2015.02.033
chicago: Hatch, Emily M., and Martin Hetzer. “Chromothripsis.” Current Biology.
Elsevier, 2015. https://doi.org/10.1016/j.cub.2015.02.033.
ieee: E. M. Hatch and M. Hetzer, “Chromothripsis,” Current Biology, vol.
25, no. 10. Elsevier, pp. PR397-R399, 2015.
ista: Hatch EM, Hetzer M. 2015. Chromothripsis. Current Biology. 25(10), PR397-R399.
mla: Hatch, Emily M., and Martin Hetzer. “Chromothripsis.” Current Biology,
vol. 25, no. 10, Elsevier, 2015, pp. PR397-R399, doi:10.1016/j.cub.2015.02.033.
short: E.M. Hatch, M. Hetzer, Current Biology 25 (2015) PR397-R399.
date_created: 2022-04-07T07:49:00Z
date_published: 2015-05-18T00:00:00Z
date_updated: 2022-07-18T08:34:34Z
day: '18'
doi: 10.1016/j.cub.2015.02.033
extern: '1'
external_id:
pmid:
- '25989073'
intvolume: ' 25'
issue: '10'
keyword:
- General Agricultural and Biological Sciences
- General Biochemistry
- Genetics and Molecular Biology
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.cub.2015.02.033
month: '05'
oa: 1
oa_version: Published Version
page: PR397-R399
pmid: 1
publication: Current Biology
publication_identifier:
issn:
- 0960-9822
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Chromothripsis
type: journal_article
user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd
volume: 25
year: '2015'
...
---
_id: '11519'
abstract:
- lang: eng
text: 'Faint Lyα emitters become increasingly rarer toward the reionization epoch
(z ∼ 6–7). However, observations from a very large (∼5 deg2) Lyα narrow-band survey
at z = 6.6 show that this is not the case for the most luminous emitters, capable
of ionizing their own local bubbles. Here we present follow-up observations of
the two most luminous Lyα candidates in the COSMOS field: “MASOSA” and “CR7.”
We used X-SHOOTER, SINFONI, and FORS2 on the Very Large Telescope, and DEIMOS
on Keck, to confirm both candidates beyond any doubt. We find redshifts of z =
6.541 and z = 6.604 for “MASOSA” and “CR7,” respectively. MASOSA has a strong
detection in Lyα with a line width of 386 ± 30 km s−1 (FWHM) and with very high
EW0 (>200 Å), but undetected in the continuum, implying very low stellar mass
and a likely young, metal-poor stellar population. “CR7,” with an observed Lyα
luminosity of 1043.92±0.05 erg s−1 is the most luminous Lyα emitter ever found
at z > 6 and is spatially extended (∼16 kpc). “CR7” reveals a narrow Lyα line
with 266 ± 15 km s−1 FWHM, being detected in the near-infrared (NIR) (rest-frame
UV; β = −2.3 ± 0.1) and in IRAC/Spitzer. We detect a narrow He II 1640 Å emission
line (6σ, FWHM = 130 ± 30 km s−1 ) in CR7 which can explain the clear excess seen
in the J-band photometry (EW0 ∼ 80 Å). We find no other emission lines from the
UV to the NIR in our X-SHOOTER spectra (He II/O III] 1663 Å > 3 and He II/C III]
1908 Å > 2.5). We conclude that CR7 is best explained by a combination of a PopIII-like
population, which dominates the rest-frame UV and the nebular emission, and a
more normal stellar population, which presumably dominates the mass. Hubble Space
Telescope/WFC3 observations show that the light is indeed spatially separated
between a very blue component, coincident with Lyα and He II emission, and two
red components (∼5 kpc away), which dominate the mass. Our findings are consistent
with theoretical predictions of a PopIII wave, with PopIII star formation migrating
away from the original sites of star formation.'
acknowledgement: We thank the anonymous reviewer for useful and constructive comments
and suggestions which greatly improved the quality and clarity of our work. D.S.
acknowledges financial support from the Netherlands Organisation for Scientific
research (NWO) through a Veni fellowship, from FCT through a FCT Investigator Starting
Grant and Start-up Grant (IF/01154/2012/CP0189/CT0010), from FCT grant UID/FIS/04434/2013,
and from LSF and LKBF. J.M. acknowledges the award of a Huygens PhD fellowship.
H.R. acknowledges support from the ERC Advanced Investigator program NewClusters
321271. The authors thank Mark Dijkstra, Bhaskar Agarwal, Jarrett Johnson, Andrea
Ferrara, Jarle Brinchmann, Rebecca Bowler, George Becker, Emma Curtis-Lake, Milos
Milosavljevic, Raffaella Schneider, Paul Shapiro, and Erik Zackrisson for interesting,
stimulating and helpful discussions. The authors are extremely grateful to ESO for
the award of ESO DDT time (294.A-5018 and 294.A-5039) which allowed the spectroscopic
confirmation of both sources and the detailed investigation of their nature. Observations
are also based on data from W.M. Keck Observatory. The W.M. Keck Observatory is
operated as a scientific partnership of Caltech, the University of California and
the National Aeronautics and Space Administration. Based on observations obtained
with MegaPrime/Megacam, a joint project of CFHT and CEA/IRFU, at the Canada–France–Hawaii
Telescope (CFHT) which is operated by the National Research Council (NRC) of Canada,
the Institut National des Science de lUnivers of the Centre National de la Recherche
Scientifique (CNRS) of France, and the University of Hawaii. This work is based
in part on data products produced at Terapix available at the Canadian Astronomy
Data Centre as part of the Canada–France–Hawaii Telescope Legacy Survey, a collaborative
project of NRC and CNRS. Based on data products from observations made with ESO
Telescopes at the La Silla Paranal Observatory under ESO programme IDs 294.A-5018,
294.A-5039, and 179.A-2005, and on data products produced by TERAPIX and the Cambridge
Astronomy Survey Unit on behalf of the UltraVISTA consortium. The authors acknowledge
the award of service time (SW2014b20) on the William Herschel Telescope (WHT). WHT
and its service programme are operated on the island of La Palma by the Isaac Newton
Group in the Spanish Observatorio del Roque de los Muchachos of the Instituto de
Astrofisica de Canarias.
article_processing_charge: No
article_type: original
author:
- first_name: David
full_name: Sobral, David
last_name: Sobral
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
- first_name: Behnam
full_name: Darvish, Behnam
last_name: Darvish
- first_name: Daniel
full_name: Schaerer, Daniel
last_name: Schaerer
- first_name: Bahram
full_name: Mobasher, Bahram
last_name: Mobasher
- first_name: Huub
full_name: Röttgering, Huub
last_name: Röttgering
- first_name: Sérgio
full_name: Santos, Sérgio
last_name: Santos
- first_name: Shoubaneh
full_name: Hemmati, Shoubaneh
last_name: Hemmati
citation:
ama: 'Sobral D, Matthee JJ, Darvish B, et al. Evidence for PopIII-like stellar populations
in the most luminous Lyα emitters at the epoch of reionisation: Spectroscopic
confirmation. The Astrophysical Journal. 2015;808(2):139. doi:10.1088/0004-637X/808/2/139'
apa: 'Sobral, D., Matthee, J. J., Darvish, B., Schaerer, D., Mobasher, B., Röttgering,
H., … Hemmati, S. (2015). Evidence for PopIII-like stellar populations in the
most luminous Lyα emitters at the epoch of reionisation: Spectroscopic confirmation.
The Astrophysical Journal. IOP Publishing. https://doi.org/10.1088/0004-637X/808/2/139'
chicago: 'Sobral, David, Jorryt J Matthee, Behnam Darvish, Daniel Schaerer, Bahram
Mobasher, Huub Röttgering, Sérgio Santos, and Shoubaneh Hemmati. “Evidence for
PopIII-like Stellar Populations in the Most Luminous Lyα Emitters at the Epoch
of Reionisation: Spectroscopic Confirmation.” The Astrophysical Journal.
IOP Publishing, 2015. https://doi.org/10.1088/0004-637X/808/2/139.'
ieee: 'D. Sobral et al., “Evidence for PopIII-like stellar populations in
the most luminous Lyα emitters at the epoch of reionisation: Spectroscopic confirmation,”
The Astrophysical Journal, vol. 808, no. 2. IOP Publishing, p. 139, 2015.'
ista: 'Sobral D, Matthee JJ, Darvish B, Schaerer D, Mobasher B, Röttgering H, Santos
S, Hemmati S. 2015. Evidence for PopIII-like stellar populations in the most luminous
Lyα emitters at the epoch of reionisation: Spectroscopic confirmation. The Astrophysical
Journal. 808(2), 139.'
mla: 'Sobral, David, et al. “Evidence for PopIII-like Stellar Populations in the
Most Luminous Lyα Emitters at the Epoch of Reionisation: Spectroscopic Confirmation.”
The Astrophysical Journal, vol. 808, no. 2, IOP Publishing, 2015, p. 139,
doi:10.1088/0004-637X/808/2/139.'
short: D. Sobral, J.J. Matthee, B. Darvish, D. Schaerer, B. Mobasher, H. Röttgering,
S. Santos, S. Hemmati, The Astrophysical Journal 808 (2015) 139.
date_created: 2022-07-07T09:00:58Z
date_published: 2015-07-28T00:00:00Z
date_updated: 2022-08-18T10:30:13Z
day: '28'
doi: 10.1088/0004-637X/808/2/139
extern: '1'
external_id:
arxiv:
- '1504.01734'
intvolume: ' 808'
issue: '2'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
- dark ages
- reionization
- 'first stars – early universe – galaxies: evolution'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1504.01734
month: '07'
oa: 1
oa_version: Preprint
page: '139'
publication: The Astrophysical Journal
publication_identifier:
eissn:
- 1538-4357
issn:
- 0004-637X
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Evidence for PopIII-like stellar populations in the most luminous Lyα emitters
at the epoch of reionisation: Spectroscopic confirmation'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 808
year: '2015'
...
---
_id: '11580'
abstract:
- lang: eng
text: 'We present results from the largest contiguous narrow-band survey in the
near-infrared. We have used the wide-field infrared camera/Canada–France–Hawaii
Telescope and the lowOH2 filter (1.187 ± 0.005 μm) to survey ≈10 deg2 of contiguous
extragalactic sky in the SA22 field. A total of ∼6000 candidate emission-line
galaxies are found. We use deep ugrizJK data to obtain robust photometric redshifts.
We combine our data with the High-redshift(Z) Emission Line Survey (HiZELS), explore
spectroscopic surveys (VVDS, VIPERS) and obtain our own spectroscopic follow-up
with KMOS, FMOS and MOSFIRE to derive large samples of high-redshift emission-line
selected galaxies: 3471 Hα emitters at z = 0.8, 1343 [O III] + Hβ emitters at
z = 1.4 and 572 [O II] emitters at z = 2.2. We probe comoving volumes of >106
Mpc3 and find significant overdensities, including an 8.5σ (spectroscopically
confirmed) overdensity of Hα emitters at z = 0.81. We derive Hα, [O III] + Hβ
and [O II] luminosity functions at z = 0.8, 1.4, 2.2, respectively, and present
implications for future surveys such as Euclid. Our uniquely large volumes/areas
allow us to subdivide the samples in thousands of randomized combinations of areas
and provide a robust empirical measurement of sample/cosmic variance. We show
that surveys for star-forming/emission-line galaxies at a depth similar to ours
can only overcome cosmic-variance (errors <10 per cent) if they are based on volumes
>5 × 105 Mpc3; errors on L* and ϕ* due to sample (cosmic) variance on surveys
probing ∼104 and ∼105 Mpc3 are typically very high: ∼300 and ∼40–60 per cent,
respectively.'
acknowledgement: The authors wish to thank the anonymous reviewer for many helpful
comments and suggestions which greatly improved the clarity and quality of this
work. DS acknowledges financial support from the Netherlands Organization for Scientific
research (NWO) through a Veni fellowship, from FCT through an FCT Investigator Starting
Grant and Start-up Grant (IF/01154/2012/CP0189/CT0010), from FCT grant PEst-OE/FIS/UI2751/2014,
and from LSF and LKBF. JM acknowledges the award of a Huygens PhD fellowship. PNB
is grateful for support from STFC. IRS acknowledges support from STFC, a Leverhulme
Fellowship, the ERC Advanced Investigator programme DUSTYGAL and a Royal Society/Wolfson
Merit Award. BMJ acknowledges support from the ERC-StG grant EGGS-278202. The Dark
Cosmology Centre is funded by the DNRF. The Dark Cosmology Centre is funded by the
DNRF. JWK acknowledges support from the National Research Foundation of Korea (NRF)
grant, no. 2008-0060544, funded by the Korea government (MSIP). JPS acknowledges
support from STFC (ST/I001573/1). JC acknowledges support from the FCT-IF grant
IF/01154/2012/CP0189/CT0010. The work was only possible due to OPTICON/FP7 and the
invaluable access that it granted to the CFHT telescope. We would also like to acknowledge
the excellent work done by CFHT staff in conducting the observations in service
mode, and on delivering truly excellent data. We are also tremendously thankful
to Kentaro Aoki for the incredible support while observing at Subaru with FMOS,
and also to the Keck staff for the help with the observations with MOSFIRE. This
work is based on observations obtained with WIRCam on the CFHT, OPTICON programme
2011B/029, 2012A019 and 2012B/016. Based on observations made with ESO telescopes
at the La Silla Paranal Observatory under programmes IDs 60.A-9460 (data can be
accessed through the ESO data archive), 087.A 0337 and 089.A-0965. Based on observations
done with FMOS on Subaru under programme S14A-084, and on MOSFIRE/Keck observations
under programme U066M. Part of the data on which this analysis is based are available
from Sobral et al. (2013a). Dedicated to the memory of C. M. Sobral (1953-2014).
article_processing_charge: No
article_type: original
author:
- first_name: D.
full_name: Sobral, D.
last_name: Sobral
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
- first_name: P. N.
full_name: Best, P. N.
last_name: Best
- first_name: I.
full_name: Smail, I.
last_name: Smail
- first_name: A. A.
full_name: Khostovan, A. A.
last_name: Khostovan
- first_name: B.
full_name: Milvang-Jensen, B.
last_name: Milvang-Jensen
- first_name: J.-W.
full_name: Kim, J.-W.
last_name: Kim
- first_name: J.
full_name: Stott, J.
last_name: Stott
- first_name: J.
full_name: Calhau, J.
last_name: Calhau
- first_name: H.
full_name: Nayyeri, H.
last_name: Nayyeri
- first_name: B.
full_name: Mobasher, B.
last_name: Mobasher
citation:
ama: 'Sobral D, Matthee JJ, Best PN, et al. CF-HiZELS, an ∼10 deg2 emission-line
survey with spectroscopic follow-up: Hα, [O III] + Hβ and [O II] luminosity functions
at z = 0.8, 1.4 and 2.2 . Monthly Notices of the Royal Astronomical Society.
2015;451(3):2303-2323. doi:10.1093/mnras/stv1076'
apa: 'Sobral, D., Matthee, J. J., Best, P. N., Smail, I., Khostovan, A. A., Milvang-Jensen,
B., … Mobasher, B. (2015). CF-HiZELS, an ∼10 deg2 emission-line survey with spectroscopic
follow-up: Hα, [O III] + Hβ and [O II] luminosity functions at z = 0.8, 1.4 and
2.2 . Monthly Notices of the Royal Astronomical Society. Oxford University
Press. https://doi.org/10.1093/mnras/stv1076'
chicago: 'Sobral, D., Jorryt J Matthee, P. N. Best, I. Smail, A. A. Khostovan, B.
Milvang-Jensen, J.-W. Kim, et al. “CF-HiZELS, an ∼10 Deg2 Emission-Line Survey
with Spectroscopic Follow-up: Hα, [O III] + Hβ and [O II] Luminosity Functions
at z = 0.8, 1.4 and 2.2 .” Monthly Notices of the Royal Astronomical Society.
Oxford University Press, 2015. https://doi.org/10.1093/mnras/stv1076.'
ieee: 'D. Sobral et al., “CF-HiZELS, an ∼10 deg2 emission-line survey with
spectroscopic follow-up: Hα, [O III] + Hβ and [O II] luminosity functions at z
= 0.8, 1.4 and 2.2 ,” Monthly Notices of the Royal Astronomical Society,
vol. 451, no. 3. Oxford University Press, pp. 2303–2323, 2015.'
ista: 'Sobral D, Matthee JJ, Best PN, Smail I, Khostovan AA, Milvang-Jensen B, Kim
J-W, Stott J, Calhau J, Nayyeri H, Mobasher B. 2015. CF-HiZELS, an ∼10 deg2 emission-line
survey with spectroscopic follow-up: Hα, [O III] + Hβ and [O II] luminosity functions
at z = 0.8, 1.4 and 2.2 . Monthly Notices of the Royal Astronomical Society. 451(3),
2303–2323.'
mla: 'Sobral, D., et al. “CF-HiZELS, an ∼10 Deg2 Emission-Line Survey with Spectroscopic
Follow-up: Hα, [O III] + Hβ and [O II] Luminosity Functions at z = 0.8, 1.4 and
2.2 .” Monthly Notices of the Royal Astronomical Society, vol. 451, no.
3, Oxford University Press, 2015, pp. 2303–23, doi:10.1093/mnras/stv1076.'
short: D. Sobral, J.J. Matthee, P.N. Best, I. Smail, A.A. Khostovan, B. Milvang-Jensen,
J.-W. Kim, J. Stott, J. Calhau, H. Nayyeri, B. Mobasher, Monthly Notices of the
Royal Astronomical Society 451 (2015) 2303–2323.
date_created: 2022-07-14T09:02:22Z
date_published: 2015-08-11T00:00:00Z
date_updated: 2022-08-19T08:23:18Z
day: '11'
doi: 10.1093/mnras/stv1076
extern: '1'
external_id:
arxiv:
- '1502.06602'
intvolume: ' 451'
issue: '3'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
- 'galaxies: evolution'
- 'galaxies: formation'
- 'galaxies: luminosity function'
- mass function
- 'cosmology: observations'
- early Universe
- large-scale structure of Universe
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1502.06602
month: '08'
oa: 1
oa_version: Preprint
page: 2303-2323
publication: Monthly Notices of the Royal Astronomical Society
publication_identifier:
eissn:
- 1365-2966
issn:
- 0035-8711
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'CF-HiZELS, an ∼10 deg2 emission-line survey with spectroscopic follow-up:
Hα, [O III] + Hβ and [O II] luminosity functions at z = 0.8, 1.4 and 2.2 '
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 451
year: '2015'
...
---
_id: '11581'
abstract:
- lang: eng
text: Using wide-field narrow-band surveys, we provide a new measurement of the
z = 6.6 Lymanα emitter (LAE) luminosity function (LF), which constraints the bright
end for the first time. We use a combination of archival narrow-band NB921 data
in UDS and new NB921 measurements in SA22 and COSMOS/UltraVISTA, all observed
with the Subaru telescope, with a total area of ∼5 deg2. We exclude lower redshift
interlopers by using broad-band optical and near-infrared photometry and also
exclude three supernovae with data split over multiple epochs. Combining the UDS
and COSMOS samples, we find no evolution of the bright end of the Lyα LF between
z = 5.7 and 6.6, which is supported by spectroscopic follow-up, and conclude that
sources with Himiko-like luminosity are not as rare as previously thought, with
number densities of ∼1.5 × 10−5 Mpc−3. Combined with our wide-field SA22 measurements,
our results indicate a non-Schechter-like bright end of the LF at z = 6.6 and
a different evolution of observed faint and bright LAEs, overcoming cosmic variance.
This differential evolution is also seen in the spectroscopic follow-up of UV-selected
galaxies and is now also confirmed for LAEs, and we argue that it may be an effect
of reionization. Using a toy model, we show that such differential evolution of
the LF is expected, since brighter sources are able to ionize their surroundings
earlier, such that Lyα photons are able to escape. Our targets are excellent candidates
for detailed follow-up studies and provide the possibility to give a unique view
on the earliest stages in the formation of galaxies and reionization process.
acknowledgement: "We thank the anonymous referee for the comments and suggestions
which have improved the quality of this work. We thank Masami Ouchi for his useful
comments on an earlier version of this paper. JM acknowledges the support of a Huygens
PhD fellowship from Leiden University and is thankful for the hospitality of the
Center for Astronomy and Astrophysics of the University of Lisbon where part of
this research has been done. DS acknowledges financial support from the Netherlands
Organization for Scientific research (NWO) through a Veni fellowship, from FCT through
a FCT Investigator Starting Grant and Start-up Grant (IF/01154/2012/CP0189/CT0010)
and from FCT grant PEstOE/FIS/UI2751/2014. HR acknowledges support from the ERC
Advanced Investigator programme NewClusters 321271. We acknowledge the award of
ESO DDT time (294.A-5018) for providing the possibility of a timely publication
of this work.\r\nBased on observations with the Subaru Telescope (Programme IDs:
our observations: S14A-086; archival: S05B-027, S06A-025, S06B-010, S07A-013, S07B-008,
S08B-008 and S09A-017) and the W.M. Keck Observatory. The Subaru telescope is operated
by the National Astronomical Observatory of Japan. The W.M. Keck Observatory is
operated as a scientific partnership among the California Institute of Technology,
the University of California and the National Aeronautics and Space Administration.
Based on observations made with ESO Telescopes at the La Silla Paranal Observatory
under programme ID 294.A-5018. Based on observations obtained with MegaPrime/Megacam,
a joint project of CFHT and CEA/IRFU, at the Canada–France-Hawaii Telescope (CFHT)
which is operated by the National Research Council (NRC) of Canada, the Institut
National des Science de l’Univers of the Centre National de la Recherche Scientifique
(CNRS) of France, and the University of Hawaii. This work is based in part on data
products produced at Terapix available at the Canadian Astronomy Data Centre as
part of the CFHT Legacy Survey, a collaborative project of NRC and CNRS. Based on
data products from observations made with ESO Telescopes at the La Silla Paranal
Observatory under ESO programme ID 179.A-2005 and on data products produced by TERAPIX
and the Cambridge Astronomy Survey Unit on behalf of the UltraVISTA consortium.\r\nIn
addition to the CFHT-LS and COSMOS-UltraVISTA surveys, we are grateful for the excellent
data sets from the UKIRT-DXS, SXDF and S-COSMOS survey teams, without these legacy
surveys, this research would have been impossible. We have benefited greatly from
the public available programming language PYTHON, including the NUMPY, MATPLOTLIB,
PYFITS, SCIPY and ASTROPY packages, the astronomical imaging tools SEXTRACTOR, SWARP
and SCAMP and the indispensable TOPCAT analysis tool (Taylor 2013)"
article_processing_charge: No
article_type: original
author:
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
- first_name: David
full_name: Sobral, David
last_name: Sobral
- first_name: Sérgio
full_name: Santos, Sérgio
last_name: Santos
- first_name: Huub
full_name: Röttgering, Huub
last_name: Röttgering
- first_name: Behnam
full_name: Darvish, Behnam
last_name: Darvish
- first_name: Bahram
full_name: Mobasher, Bahram
last_name: Mobasher
citation:
ama: 'Matthee JJ, Sobral D, Santos S, Röttgering H, Darvish B, Mobasher B. Identification
of the brightest Lyα emitters at z = 6.6: implications for the evolution of the
luminosity function in the reionization era. Monthly Notices of the Royal Astronomical
Society. 2015;451(1):400-417. doi:10.1093/mnras/stv947'
apa: 'Matthee, J. J., Sobral, D., Santos, S., Röttgering, H., Darvish, B., &
Mobasher, B. (2015). Identification of the brightest Lyα emitters at z = 6.6:
implications for the evolution of the luminosity function in the reionization
era. Monthly Notices of the Royal Astronomical Society. Oxford University
Press. https://doi.org/10.1093/mnras/stv947'
chicago: 'Matthee, Jorryt J, David Sobral, Sérgio Santos, Huub Röttgering, Behnam
Darvish, and Bahram Mobasher. “Identification of the Brightest Lyα Emitters at
z = 6.6: Implications for the Evolution of the Luminosity Function in the Reionization
Era.” Monthly Notices of the Royal Astronomical Society. Oxford University
Press, 2015. https://doi.org/10.1093/mnras/stv947.'
ieee: 'J. J. Matthee, D. Sobral, S. Santos, H. Röttgering, B. Darvish, and B. Mobasher,
“Identification of the brightest Lyα emitters at z = 6.6: implications for the
evolution of the luminosity function in the reionization era,” Monthly Notices
of the Royal Astronomical Society, vol. 451, no. 1. Oxford University Press,
pp. 400–417, 2015.'
ista: 'Matthee JJ, Sobral D, Santos S, Röttgering H, Darvish B, Mobasher B. 2015.
Identification of the brightest Lyα emitters at z = 6.6: implications for the
evolution of the luminosity function in the reionization era. Monthly Notices
of the Royal Astronomical Society. 451(1), 400–417.'
mla: 'Matthee, Jorryt J., et al. “Identification of the Brightest Lyα Emitters at
z = 6.6: Implications for the Evolution of the Luminosity Function in the Reionization
Era.” Monthly Notices of the Royal Astronomical Society, vol. 451, no.
1, Oxford University Press, 2015, pp. 400–17, doi:10.1093/mnras/stv947.'
short: J.J. Matthee, D. Sobral, S. Santos, H. Röttgering, B. Darvish, B. Mobasher,
Monthly Notices of the Royal Astronomical Society 451 (2015) 400–417.
date_created: 2022-07-14T11:57:03Z
date_published: 2015-07-21T00:00:00Z
date_updated: 2022-08-19T08:25:25Z
day: '21'
doi: 10.1093/mnras/stv947
extern: '1'
external_id:
arxiv:
- '1502.07355'
intvolume: ' 451'
issue: '1'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1502.07355
month: '07'
oa: 1
oa_version: Preprint
page: 400-417
publication: Monthly Notices of the Royal Astronomical Society
publication_identifier:
eissn:
- 1365-2966
issn:
- 0035-8711
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Identification of the brightest Lyα emitters at z = 6.6: implications for
the evolution of the luminosity function in the reionization era'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 451
year: '2015'
...
---
_id: '11579'
abstract:
- lang: eng
text: CR7 is the brightest z = 6.6 Ly α emitter (LAE) known to date, and spectroscopic
follow-up by Sobral et al. suggests that CR7 might host Population (Pop) III stars.
We examine this interpretation using cosmological hydrodynamical simulations.
Several simulated galaxies show the same ‘Pop III wave’ pattern observed in CR7.
However, to reproduce the extreme CR7 Ly α/He II1640 line luminosities (Lα/HeII)
a top-heavy initial mass function and a massive ( ≳ 107 M⊙) Pop III burst with
age ≲ 2 Myr are required. Assuming that the observed properties of Ly α and He II
emission are typical for Pop III, we predict that in the COSMOS/UDS/SA22 fields,
14 out of the 30 LAEs at z = 6.6 with Lα > 1043.3 erg s−1 should also host Pop
III stars producing an observable LHeII≳1042.7ergs−1. As an alternate explanation,
we explore the possibility that CR7 is instead powered by accretion on to a direct
collapse black hole. Our model predicts Lα, LHeII, and X-ray luminosities that
are in agreement with the observations. In any case, the observed properties of
CR7 indicate that this galaxy is most likely powered by sources formed from pristine
gas. We propose that further X-ray observations can distinguish between the two
above scenarios.
acknowledgement: SS acknowledges support from the Netherlands Organization for Scientific
research (NWO), VENI grant 639.041.233. RS acknowledges support from the European
Research Council under the European Union (FP/2007-2013)/ERC grant agreement no.
306476. DS acknowledges (i) financial support from the NWO through a Veni fellowship
and (ii) funding from FCT through a FCT Investigator Starting Grant and Start-up
Grant (IF/01154/2012/CP0189/CT0010) and from FCT grant PEstOE/FIS/UI2751/2014.
article_processing_charge: No
article_type: original
author:
- first_name: A.
full_name: Pallottini, A.
last_name: Pallottini
- first_name: A.
full_name: Ferrara, A.
last_name: Ferrara
- first_name: F.
full_name: Pacucci, F.
last_name: Pacucci
- first_name: S.
full_name: Gallerani, S.
last_name: Gallerani
- first_name: S.
full_name: Salvadori, S.
last_name: Salvadori
- first_name: R.
full_name: Schneider, R.
last_name: Schneider
- first_name: D.
full_name: Schaerer, D.
last_name: Schaerer
- first_name: D.
full_name: Sobral, D.
last_name: Sobral
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
citation:
ama: 'Pallottini A, Ferrara A, Pacucci F, et al. The brightest Lyα emitter: Pop
III or black hole? Monthly Notices of the Royal Astronomical Society. 2015;453(3):2465-2470.
doi:10.1093/mnras/stv1795'
apa: 'Pallottini, A., Ferrara, A., Pacucci, F., Gallerani, S., Salvadori, S., Schneider,
R., … Matthee, J. J. (2015). The brightest Lyα emitter: Pop III or black hole?
Monthly Notices of the Royal Astronomical Society. Oxford University Press.
https://doi.org/10.1093/mnras/stv1795'
chicago: 'Pallottini, A., A. Ferrara, F. Pacucci, S. Gallerani, S. Salvadori, R.
Schneider, D. Schaerer, D. Sobral, and Jorryt J Matthee. “The Brightest Lyα Emitter:
Pop III or Black Hole?” Monthly Notices of the Royal Astronomical Society.
Oxford University Press, 2015. https://doi.org/10.1093/mnras/stv1795.'
ieee: 'A. Pallottini et al., “The brightest Lyα emitter: Pop III or black
hole?,” Monthly Notices of the Royal Astronomical Society, vol. 453, no.
3. Oxford University Press, pp. 2465–2470, 2015.'
ista: 'Pallottini A, Ferrara A, Pacucci F, Gallerani S, Salvadori S, Schneider R,
Schaerer D, Sobral D, Matthee JJ. 2015. The brightest Lyα emitter: Pop III or
black hole? Monthly Notices of the Royal Astronomical Society. 453(3), 2465–2470.'
mla: 'Pallottini, A., et al. “The Brightest Lyα Emitter: Pop III or Black Hole?”
Monthly Notices of the Royal Astronomical Society, vol. 453, no. 3, Oxford
University Press, 2015, pp. 2465–70, doi:10.1093/mnras/stv1795.'
short: A. Pallottini, A. Ferrara, F. Pacucci, S. Gallerani, S. Salvadori, R. Schneider,
D. Schaerer, D. Sobral, J.J. Matthee, Monthly Notices of the Royal Astronomical
Society 453 (2015) 2465–2470.
date_created: 2022-07-14T08:58:36Z
date_published: 2015-11-01T00:00:00Z
date_updated: 2022-08-19T08:19:23Z
day: '01'
doi: 10.1093/mnras/stv1795
extern: '1'
external_id:
arxiv:
- '1506.07173'
intvolume: ' 453'
issue: '3'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
- black hole physics
- 'stars: Population III'
- 'galaxies: high-redshift'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1506.07173
month: '11'
oa: 1
oa_version: Preprint
page: 2465-2470
publication: Monthly Notices of the Royal Astronomical Society
publication_identifier:
eissn:
- 1365-2966
issn:
- 0035-8711
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'The brightest Lyα emitter: Pop III or black hole?'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 453
year: '2015'
...
---
_id: '11668'
abstract:
- lang: eng
text: "We study multiple keyword sponsored search auctions with budgets. Each keyword
has multiple ad slots with a click-through rate. The bidders have additive valuations,
which are linear in the click-through rates, and budgets, which are restricting
their overall payments. Additionally, the number of slots per keyword assigned
to a bidder is bounded.\r\n\r\nWe show the following results: (1) We give the
first mechanism for multiple keywords, where click-through rates differ among
slots. Our mechanism is incentive compatible in expectation, individually rational
in expectation, and Pareto optimal. (2) We study the combinatorial setting, where
each bidder is only interested in a subset of the keywords. We give an incentive
compatible, individually rational, Pareto-optimal, and deterministic mechanism
for identical click-through rates. (3) We give an impossibility result for incentive
compatible, individually rational, Pareto-optimal, and deterministic mechanisms
for bidders with diminishing marginal valuations."
article_number: '2'
article_processing_charge: No
article_type: original
author:
- first_name: Riccardo
full_name: Colini-Baldeschi, Riccardo
last_name: Colini-Baldeschi
- first_name: Stefano
full_name: Leonardi, Stefano
last_name: Leonardi
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Martin
full_name: Starnberger, Martin
last_name: Starnberger
citation:
ama: Colini-Baldeschi R, Leonardi S, Henzinger MH, Starnberger M. On multiple keyword
sponsored search auctions with budgets. ACM Transactions on Economics and Computation.
2015;4(1). doi:10.1145/2818357
apa: Colini-Baldeschi, R., Leonardi, S., Henzinger, M. H., & Starnberger, M.
(2015). On multiple keyword sponsored search auctions with budgets. ACM Transactions
on Economics and Computation. Association for Computing Machinery. https://doi.org/10.1145/2818357
chicago: Colini-Baldeschi, Riccardo, Stefano Leonardi, Monika H Henzinger, and Martin
Starnberger. “On Multiple Keyword Sponsored Search Auctions with Budgets.” ACM
Transactions on Economics and Computation. Association for Computing Machinery,
2015. https://doi.org/10.1145/2818357.
ieee: R. Colini-Baldeschi, S. Leonardi, M. H. Henzinger, and M. Starnberger, “On
multiple keyword sponsored search auctions with budgets,” ACM Transactions
on Economics and Computation, vol. 4, no. 1. Association for Computing Machinery,
2015.
ista: Colini-Baldeschi R, Leonardi S, Henzinger MH, Starnberger M. 2015. On multiple
keyword sponsored search auctions with budgets. ACM Transactions on Economics
and Computation. 4(1), 2.
mla: Colini-Baldeschi, Riccardo, et al. “On Multiple Keyword Sponsored Search Auctions
with Budgets.” ACM Transactions on Economics and Computation, vol. 4, no.
1, 2, Association for Computing Machinery, 2015, doi:10.1145/2818357.
short: R. Colini-Baldeschi, S. Leonardi, M.H. Henzinger, M. Starnberger, ACM Transactions
on Economics and Computation 4 (2015).
date_created: 2022-07-27T11:54:56Z
date_published: 2015-12-05T00:00:00Z
date_updated: 2023-02-09T10:03:35Z
day: '05'
doi: 10.1145/2818357
extern: '1'
intvolume: ' 4'
issue: '1'
keyword:
- Algorithms
- Economics
- Clinching ascending auction
- auctions with budgets
- Sponsored search auctions
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://eprints.cs.univie.ac.at/3510/
month: '12'
oa: 1
oa_version: Submitted Version
publication: ACM Transactions on Economics and Computation
publication_identifier:
eissn:
- 2167-8383
issn:
- 2167-8375
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
scopus_import: '1'
status: public
title: On multiple keyword sponsored search auctions with budgets
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 4
year: '2015'
...
---
_id: '11669'
abstract:
- lang: eng
text: We study individual rational, Pareto-optimal, and incentive compatible mechanisms
for auctions with heterogeneous items and budget limits. We consider settings
with multiunit demand and additive valuations. For single-dimensional valuations
we prove a positive result for randomized mechanisms, and a negative result for
deterministic mechanisms. While the positive result allows for private budgets,
the negative result is for public budgets. For multidimensional valuations and
public budgets we prove an impossibility result that applies to deterministic
and randomized mechanisms. Taken together this shows the power of randomization
in certain settings with heterogeneous items, but it also shows its limitations.
article_number: '4'
article_processing_charge: No
article_type: original
author:
- first_name: Paul
full_name: Dütting, Paul
last_name: Dütting
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Martin
full_name: Starnberger, Martin
last_name: Starnberger
citation:
ama: Dütting P, Henzinger MH, Starnberger M. Auctions for heterogeneous items and
budget limits. ACM Transactions on Economics and Computation. 2015;4(1).
doi:10.1145/2818351
apa: Dütting, P., Henzinger, M. H., & Starnberger, M. (2015). Auctions for heterogeneous
items and budget limits. ACM Transactions on Economics and Computation.
Association for Computing Machinery. https://doi.org/10.1145/2818351
chicago: Dütting, Paul, Monika H Henzinger, and Martin Starnberger. “Auctions for
Heterogeneous Items and Budget Limits.” ACM Transactions on Economics and Computation.
Association for Computing Machinery, 2015. https://doi.org/10.1145/2818351.
ieee: P. Dütting, M. H. Henzinger, and M. Starnberger, “Auctions for heterogeneous
items and budget limits,” ACM Transactions on Economics and Computation,
vol. 4, no. 1. Association for Computing Machinery, 2015.
ista: Dütting P, Henzinger MH, Starnberger M. 2015. Auctions for heterogeneous items
and budget limits. ACM Transactions on Economics and Computation. 4(1), 4.
mla: Dütting, Paul, et al. “Auctions for Heterogeneous Items and Budget Limits.”
ACM Transactions on Economics and Computation, vol. 4, no. 1, 4, Association
for Computing Machinery, 2015, doi:10.1145/2818351.
short: P. Dütting, M.H. Henzinger, M. Starnberger, ACM Transactions on Economics
and Computation 4 (2015).
date_created: 2022-07-27T12:09:15Z
date_published: 2015-12-05T00:00:00Z
date_updated: 2022-09-09T12:08:37Z
day: '05'
doi: 10.1145/2818351
extern: '1'
external_id:
arxiv:
- '1209.6448'
intvolume: ' 4'
issue: '1'
keyword:
- Algorithmic game theory
- auction theory
- Clinching auction
- Pareto optimality
- Budget limits
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1209.6448
month: '12'
oa: 1
oa_version: Preprint
publication: ACM Transactions on Economics and Computation
publication_identifier:
eissn:
- 2167-8383
issn:
- 2167-8375
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
scopus_import: '1'
status: public
title: Auctions for heterogeneous items and budget limits
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 4
year: '2015'
...
---
_id: '11670'
abstract:
- lang: eng
text: Auctions are widely used on the Web. Applications range from sponsored search
to platforms such as eBay. In these and in many other applications the auctions
in use are single-/multi-item auctions with unit demand. The main drawback of
standard mechanisms for this type of auctions, such as VCG and GSP, is the limited
expressiveness that they offer to the bidders. The General Auction Mechanism (GAM)
of Aggarwal et al. [2009] takes a first step toward addressing the problem of
limited expressiveness by computing a bidder optimal, envy-free outcome for linear
utility functions with identical slopes and a single discontinuity per bidder-item
pair. We show that in many practical situations this does not suffice to adequately
model the preferences of the bidders, and we overcome this problem by presenting
the first mechanism for piecewise linear utility functions with nonidentical slopes
and multiple discontinuities. Our mechanism runs in polynomial time. Like GAM
it is incentive compatible for inputs that fulfill a certain nondegeneracy assumption,
but our requirement is more general than the requirement of GAM. For discontinuous
utility functions that are nondegenerate as well as for continuous utility functions
the outcome of our mechanism is a competitive equilibrium. We also show how our
mechanism can be used to compute approximately bidder optimal, envy-free outcomes
for a general class of continuous utility functions via piecewise linear approximation.
Finally, we prove hardness results for even more expressive settings.
acknowledgement: We would like to thank Veronika Loitzenbauer and the anonymous referees
for their valuable feedback.
article_number: '1'
article_processing_charge: No
article_type: original
author:
- first_name: Paul
full_name: Dütting, Paul
last_name: Dütting
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Ingmar
full_name: Weber, Ingmar
last_name: Weber
citation:
ama: Dütting P, Henzinger MH, Weber I. An expressive mechanism for auctions on the
web. ACM Transactions on Economics and Computation. 2015;4(1). doi:10.1145/2716312
apa: Dütting, P., Henzinger, M. H., & Weber, I. (2015). An expressive mechanism
for auctions on the web. ACM Transactions on Economics and Computation.
Association for Computing Machinery. https://doi.org/10.1145/2716312
chicago: Dütting, Paul, Monika H Henzinger, and Ingmar Weber. “An Expressive Mechanism
for Auctions on the Web.” ACM Transactions on Economics and Computation.
Association for Computing Machinery, 2015. https://doi.org/10.1145/2716312.
ieee: P. Dütting, M. H. Henzinger, and I. Weber, “An expressive mechanism for auctions
on the web,” ACM Transactions on Economics and Computation, vol. 4, no.
1. Association for Computing Machinery, 2015.
ista: Dütting P, Henzinger MH, Weber I. 2015. An expressive mechanism for auctions
on the web. ACM Transactions on Economics and Computation. 4(1), 1.
mla: Dütting, Paul, et al. “An Expressive Mechanism for Auctions on the Web.” ACM
Transactions on Economics and Computation, vol. 4, no. 1, 1, Association for
Computing Machinery, 2015, doi:10.1145/2716312.
short: P. Dütting, M.H. Henzinger, I. Weber, ACM Transactions on Economics and Computation
4 (2015).
date_created: 2022-07-27T12:43:18Z
date_published: 2015-12-02T00:00:00Z
date_updated: 2023-02-09T10:08:41Z
day: '02'
doi: 10.1145/2716312
extern: '1'
intvolume: ' 4'
issue: '1'
keyword:
- Computational Mathematics
- Marketing
- Economics and Econometrics
- Statistics and Probability
- Computer Science (miscellaneous)
language:
- iso: eng
month: '12'
oa_version: None
publication: ACM Transactions on Economics and Computation
publication_identifier:
eissn:
- 2167-8383
issn:
- 2167-8375
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
scopus_import: '1'
status: public
title: An expressive mechanism for auctions on the web
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 4
year: '2015'
...
---
_id: '11774'
abstract:
- lang: eng
text: "Combinatorial auctions (CA) are a well-studied area in algorithmic mechanism
design. However, contrary to the standard model, empirical studies suggest that
a bidder’s valuation often does not depend solely on the goods assigned to him.
For instance, in adwords auctions an advertiser might not want his ads to be displayed
next to his competitors’ ads. In this paper, we propose and analyze several natural
graph-theoretic models that incorporate such negative externalities, in which
bidders form a directed conflict graph with maximum out-degree Δ. We design algorithms
and truthful mechanisms for social welfare maximization that attain approximation
ratios depending on Δ.\r\n\r\nFor CA, our results are twofold: (1) A lottery that
eliminates conflicts by discarding bidders/items independent of the bids. It allows
to apply any truthful \U0001D6FC-approximation mechanism for conflict-free valuations
and yields an \U0001D4AA(\U0001D6FCΔ)-approximation mechanism. (2) For fractionally
sub-additive valuations, we design a rounding algorithm via a novel combination
of a semi-definite program and a linear program, resulting in a cone program;
the approximation ratio is \U0001D4AA((ΔloglogΔ)/logΔ). The ratios are almost
optimal given existing hardness results.\r\n\r\nFor adwords auctions, we present
several algorithms for the most relevant scenario when the number of items is
small. In particular, we design a truthful mechanism with approximation ratio
\U0001D45C(Δ) when the number of items is only logarithmic in the number of bidders."
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Yun Kuen
full_name: Cheung, Yun Kuen
last_name: Cheung
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Martin
full_name: Hoefer, Martin
last_name: Hoefer
- first_name: Martin
full_name: Starnberger, Martin
last_name: Starnberger
citation:
ama: 'Cheung YK, Henzinger MH, Hoefer M, Starnberger M. Combinatorial auctions with
conflict-based externalities. In: 11th International Conference on Web and
Internet Economics. Vol 9470. Springer Nature; 2015:230–243. doi:10.1007/978-3-662-48995-6_17'
apa: 'Cheung, Y. K., Henzinger, M. H., Hoefer, M., & Starnberger, M. (2015).
Combinatorial auctions with conflict-based externalities. In 11th International
Conference on Web and Internet Economics (Vol. 9470, pp. 230–243). Amsterdam,
Netherlands: Springer Nature. https://doi.org/10.1007/978-3-662-48995-6_17'
chicago: Cheung, Yun Kuen, Monika H Henzinger, Martin Hoefer, and Martin Starnberger.
“Combinatorial Auctions with Conflict-Based Externalities.” In 11th International
Conference on Web and Internet Economics, 9470:230–243. Springer Nature, 2015.
https://doi.org/10.1007/978-3-662-48995-6_17.
ieee: Y. K. Cheung, M. H. Henzinger, M. Hoefer, and M. Starnberger, “Combinatorial
auctions with conflict-based externalities,” in 11th International Conference
on Web and Internet Economics, Amsterdam, Netherlands, 2015, vol. 9470, pp.
230–243.
ista: 'Cheung YK, Henzinger MH, Hoefer M, Starnberger M. 2015. Combinatorial auctions
with conflict-based externalities. 11th International Conference on Web and Internet
Economics. WINE: International Conference on Web and Internet Economics, LNCS,
vol. 9470, 230–243.'
mla: Cheung, Yun Kuen, et al. “Combinatorial Auctions with Conflict-Based Externalities.”
11th International Conference on Web and Internet Economics, vol. 9470,
Springer Nature, 2015, pp. 230–243, doi:10.1007/978-3-662-48995-6_17.
short: Y.K. Cheung, M.H. Henzinger, M. Hoefer, M. Starnberger, in:, 11th International
Conference on Web and Internet Economics, Springer Nature, 2015, pp. 230–243.
conference:
end_date: 2015-12-12
location: Amsterdam, Netherlands
name: 'WINE: International Conference on Web and Internet Economics'
start_date: 2015-12-09
date_created: 2022-08-08T13:54:32Z
date_published: 2015-12-09T00:00:00Z
date_updated: 2023-02-10T09:08:30Z
day: '09'
doi: 10.1007/978-3-662-48995-6_17
extern: '1'
external_id:
arxiv:
- '1509.09147'
intvolume: ' 9470'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.1509.09147
month: '12'
oa: 1
oa_version: Preprint
page: 230–243
publication: 11th International Conference on Web and Internet Economics
publication_identifier:
eisbn:
- '9783662489956'
isbn:
- '9783662489949'
issn:
- 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Combinatorial auctions with conflict-based externalities
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 9470
year: '2015'
...
---
_id: '11773'
abstract:
- lang: eng
text: "Ad exchanges are an emerging platform for trading advertisement slots on
the web with billions of dollars revenue per year. Every time a user visits a
web page, the publisher of that web page can ask an ad exchange to auction off
the ad slots on this page to determine which advertisements are shown at which
price. Due to the high volume of traffic, ad networks typically act as mediators
for individual advertisers at ad exchanges. If multiple advertisers in an ad network
are interested in the ad slots of the same auction, the ad network might use a
“local” auction to resell the obtained ad slots among its advertisers.\r\n\r\nIn
this work we want to deepen the theoretical understanding of these new markets
by analyzing them from the viewpoint of combinatorial auctions. Prior work studied
mostly single-item auctions, while we allow the advertisers to express richer
preferences over multiple items. We develop a game-theoretic model for the entanglement
of the central auction at the ad exchange with the local auctions at the ad networks.
We consider the incentives of all three involved parties and suggest a three-party
competitive equilibrium, an extension of the Walrasian equilibrium that ensures
envy-freeness for all participants. We show the existence of a three-party competitive
equilibrium and a polynomial-time algorithm to find one for gross-substitute bidder
valuations."
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Oren
full_name: Ben-Zwi, Oren
last_name: Ben-Zwi
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Veronika
full_name: Loitzenbauer, Veronika
last_name: Loitzenbauer
citation:
ama: 'Ben-Zwi O, Henzinger MH, Loitzenbauer V. Ad exchange: Envy-free auctions with
mediators. In: 11th International Conference on Web and Internet Economics.
Vol 9470. Springer Nature; 2015:104–117. doi:10.1007/978-3-662-48995-6_8'
apa: 'Ben-Zwi, O., Henzinger, M. H., & Loitzenbauer, V. (2015). Ad exchange:
Envy-free auctions with mediators. In 11th International Conference on Web
and Internet Economics (Vol. 9470, pp. 104–117). Amsterdam, Netherlands: Springer
Nature. https://doi.org/10.1007/978-3-662-48995-6_8'
chicago: 'Ben-Zwi, Oren, Monika H Henzinger, and Veronika Loitzenbauer. “Ad Exchange:
Envy-Free Auctions with Mediators.” In 11th International Conference on Web
and Internet Economics, 9470:104–117. Springer Nature, 2015. https://doi.org/10.1007/978-3-662-48995-6_8.'
ieee: 'O. Ben-Zwi, M. H. Henzinger, and V. Loitzenbauer, “Ad exchange: Envy-free
auctions with mediators,” in 11th International Conference on Web and Internet
Economics, Amsterdam, Netherlands, 2015, vol. 9470, pp. 104–117.'
ista: 'Ben-Zwi O, Henzinger MH, Loitzenbauer V. 2015. Ad exchange: Envy-free auctions
with mediators. 11th International Conference on Web and Internet Economics. WINE:
International Conference on Web and Internet Economics, LNCS, vol. 9470, 104–117.'
mla: 'Ben-Zwi, Oren, et al. “Ad Exchange: Envy-Free Auctions with Mediators.” 11th
International Conference on Web and Internet Economics, vol. 9470, Springer
Nature, 2015, pp. 104–117, doi:10.1007/978-3-662-48995-6_8.'
short: O. Ben-Zwi, M.H. Henzinger, V. Loitzenbauer, in:, 11th International Conference
on Web and Internet Economics, Springer Nature, 2015, pp. 104–117.
conference:
end_date: 2015-09-12
location: Amsterdam, Netherlands
name: 'WINE: International Conference on Web and Internet Economics'
start_date: 2015-09-09
date_created: 2022-08-08T13:33:56Z
date_published: 2015-12-09T00:00:00Z
date_updated: 2023-02-10T09:06:23Z
day: '09'
doi: 10.1007/978-3-662-48995-6_8
extern: '1'
external_id:
arxiv:
- '1604.05562'
intvolume: ' 9470'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.1604.05562
month: '12'
oa: 1
oa_version: Preprint
page: 104–117
publication: 11th International Conference on Web and Internet Economics
publication_identifier:
eisbn:
- '9783662489956'
isbn:
- '9783662489949'
issn:
- 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Ad exchange: Envy-free auctions with mediators'
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 9470
year: '2015'
...
---
_id: '11785'
abstract:
- lang: eng
text: "Recently we presented the first algorithm for maintaining the set of nodes
reachable from a source node in a directed graph that is modified by edge deletions
with \U0001D45C(\U0001D45A\U0001D45B) total update time, where \U0001D45A is the
number of edges and \U0001D45B is the number of nodes in the graph [Henzinger
et al. STOC 2014]. The algorithm is a combination of several different algorithms,
each for a different \U0001D45A vs. \U0001D45B trade-off. For the case of \U0001D45A=Θ(\U0001D45B1.5)
the running time is \U0001D442(\U0001D45B2.47), just barely below \U0001D45A\U0001D45B=Θ(\U0001D45B2.5).
In this paper we simplify the previous algorithm using new algorithmic ideas and
achieve an improved running time of \U0001D442̃ (min(\U0001D45A7/6\U0001D45B2/3,\U0001D45A3/4\U0001D45B5/4+\U0001D45C(1),\U0001D45A2/3\U0001D45B4/3+\U0001D45C(1)+\U0001D45A3/7\U0001D45B12/7+\U0001D45C(1))).
This gives, e.g., \U0001D442(\U0001D45B2.36) for the notorious case \U0001D45A=Θ(\U0001D45B1.5).
We obtain the same upper bounds for the problem of maintaining the strongly connected
components of a directed graph undergoing edge deletions. Our algorithms are correct
with high probabililty against an oblivious adversary."
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Sebastian
full_name: Krinninger, Sebastian
last_name: Krinninger
- first_name: Danupon
full_name: Nanongkai, Danupon
last_name: Nanongkai
citation:
ama: 'Henzinger MH, Krinninger S, Nanongkai D. Improved algorithms for decremental
single-source reachability on directed graphs. In: 42nd International Colloquium
on Automata, Languages and Programming. Vol 9134. Springer Nature; 2015:725-736.
doi:10.1007/978-3-662-47672-7_59'
apa: 'Henzinger, M. H., Krinninger, S., & Nanongkai, D. (2015). Improved algorithms
for decremental single-source reachability on directed graphs. In 42nd International
Colloquium on Automata, Languages and Programming (Vol. 9134, pp. 725–736).
Kyoto, Japan: Springer Nature. https://doi.org/10.1007/978-3-662-47672-7_59'
chicago: Henzinger, Monika H, Sebastian Krinninger, and Danupon Nanongkai. “Improved
Algorithms for Decremental Single-Source Reachability on Directed Graphs.” In
42nd International Colloquium on Automata, Languages and Programming, 9134:725–36.
Springer Nature, 2015. https://doi.org/10.1007/978-3-662-47672-7_59.
ieee: M. H. Henzinger, S. Krinninger, and D. Nanongkai, “Improved algorithms for
decremental single-source reachability on directed graphs,” in 42nd International
Colloquium on Automata, Languages and Programming, Kyoto, Japan, 2015, vol.
9134, pp. 725–736.
ista: 'Henzinger MH, Krinninger S, Nanongkai D. 2015. Improved algorithms for decremental
single-source reachability on directed graphs. 42nd International Colloquium on
Automata, Languages and Programming. ICALP: International Colloquium on Automata,
Languages, and Programming, LNCS, vol. 9134, 725–736.'
mla: Henzinger, Monika H., et al. “Improved Algorithms for Decremental Single-Source
Reachability on Directed Graphs.” 42nd International Colloquium on Automata,
Languages and Programming, vol. 9134, Springer Nature, 2015, pp. 725–36, doi:10.1007/978-3-662-47672-7_59.
short: M.H. Henzinger, S. Krinninger, D. Nanongkai, in:, 42nd International Colloquium
on Automata, Languages and Programming, Springer Nature, 2015, pp. 725–736.
conference:
end_date: 2015-07-10
location: Kyoto, Japan
name: 'ICALP: International Colloquium on Automata, Languages, and Programming'
start_date: 2015-07-06
date_created: 2022-08-11T08:51:32Z
date_published: 2015-01-01T00:00:00Z
date_updated: 2023-02-10T09:10:26Z
day: '01'
doi: 10.1007/978-3-662-47672-7_59
extern: '1'
external_id:
arxiv:
- '1612.03856'
intvolume: ' 9134'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1612.03856
month: '01'
oa: 1
oa_version: Preprint
page: 725 - 736
publication: 42nd International Colloquium on Automata, Languages and Programming
publication_identifier:
isbn:
- '9783662476710'
issn:
- 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Improved algorithms for decremental single-source reachability on directed
graphs
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 9134
year: '2015'
...
---
_id: '11787'
abstract:
- lang: eng
text: "We present faster algorithms for computing the 2-edge and 2-vertex strongly
connected components of a directed graph. While in undirected graphs the 2-edge
and 2-vertex connected components can be found in linear time, in directed graphs
with m edges and n vertices only rather simple O(m n)-time algorithms were known.
We use a hierarchical sparsification technique to obtain algorithms that run in
time \U0001D442(\U0001D45B2). For 2-edge strongly connected components our algorithm
gives the first running time improvement in 20 years. Additionally we present
an \U0001D442(\U0001D45A2/log\U0001D45B)-time algorithm for 2-edge strongly connected
components, and thus improve over the O(m n) running time also when \U0001D45A=\U0001D442(\U0001D45B).
Our approach extends to k-edge and k-vertex strongly connected components for
any constant k with a running time of \U0001D442(\U0001D45B2log\U0001D45B) for
k-edge-connectivity and \U0001D442(\U0001D45B3) for k-vertex-connectivity."
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Sebastian
full_name: Krinninger, Sebastian
last_name: Krinninger
- first_name: Veronika
full_name: Loitzenbauer, Veronika
last_name: Loitzenbauer
citation:
ama: 'Henzinger MH, Krinninger S, Loitzenbauer V. Finding 2-edge and 2-vertex strongly
connected components in quadratic time. In: 2nd International Colloquium on
Automata, Languages and Programming. Vol 9134. Springer Nature; 2015:713-724.
doi:10.1007/978-3-662-47672-7_58'
apa: 'Henzinger, M. H., Krinninger, S., & Loitzenbauer, V. (2015). Finding 2-edge
and 2-vertex strongly connected components in quadratic time. In 2nd International
Colloquium on Automata, Languages and Programming (Vol. 9134, pp. 713–724).
Kyoto, Japan: Springer Nature. https://doi.org/10.1007/978-3-662-47672-7_58'
chicago: Henzinger, Monika H, Sebastian Krinninger, and Veronika Loitzenbauer. “Finding
2-Edge and 2-Vertex Strongly Connected Components in Quadratic Time.” In 2nd
International Colloquium on Automata, Languages and Programming, 9134:713–24.
Springer Nature, 2015. https://doi.org/10.1007/978-3-662-47672-7_58.
ieee: M. H. Henzinger, S. Krinninger, and V. Loitzenbauer, “Finding 2-edge and 2-vertex
strongly connected components in quadratic time,” in 2nd International Colloquium
on Automata, Languages and Programming, Kyoto, Japan, 2015, vol. 9134, pp.
713–724.
ista: 'Henzinger MH, Krinninger S, Loitzenbauer V. 2015. Finding 2-edge and 2-vertex
strongly connected components in quadratic time. 2nd International Colloquium
on Automata, Languages and Programming. ICALP: International Colloquium on Automata,
Languages, and Programming, LNCS, vol. 9134, 713–724.'
mla: Henzinger, Monika H., et al. “Finding 2-Edge and 2-Vertex Strongly Connected
Components in Quadratic Time.” 2nd International Colloquium on Automata, Languages
and Programming, vol. 9134, Springer Nature, 2015, pp. 713–24, doi:10.1007/978-3-662-47672-7_58.
short: M.H. Henzinger, S. Krinninger, V. Loitzenbauer, in:, 2nd International Colloquium
on Automata, Languages and Programming, Springer Nature, 2015, pp. 713–724.
conference:
end_date: 2015-07-10
location: Kyoto, Japan
name: 'ICALP: International Colloquium on Automata, Languages, and Programming'
start_date: 2015-07-06
date_created: 2022-08-11T09:38:34Z
date_published: 2015-07-06T00:00:00Z
date_updated: 2023-02-10T09:21:47Z
day: '06'
doi: 10.1007/978-3-662-47672-7_58
extern: '1'
external_id:
arxiv:
- '1412.6466'
intvolume: ' 9134'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1412.6466
month: '07'
oa: 1
oa_version: Preprint
page: 713 - 724
publication: 2nd International Colloquium on Automata, Languages and Programming
publication_identifier:
isbn:
- '9783662476710'
issn:
- 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Finding 2-edge and 2-vertex strongly connected components in quadratic time
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 9134
year: '2015'
...
---
_id: '11788'
abstract:
- lang: eng
text: "Ad exchanges are becoming an increasingly popular way to sell advertisement
slots on the internet. An ad exchange is basically a spot market for ad impressions.
A publisher who has already signed contracts reserving advertisement impressions
on his pages can choose between assigning a new ad impression for a new page view
to a contracted advertiser or to sell it at an ad exchange. This leads to an online
revenue maximization problem for the publisher. Given a new impression to sell
decide whether (a) to assign it to a contracted advertiser and if so to which
one or (b) to sell it at the ad exchange and if so at which reserve price. We
make no assumptions about the distribution of the advertiser valuations that participate
in the ad exchange and show that there exists a simple primal-dual based online
algorithm, whose lower bound for the revenue converges to \U0001D445\U0001D434\U0001D437\U0001D44B+\U0001D445\U0001D434(1−1/\U0001D452),
where \U0001D445\U0001D434\U0001D437\U0001D44B is the revenue that the optimum
algorithm achieves from the ad exchange and \U0001D445\U0001D434 is the revenue
that the optimum algorithm achieves from the contracted advertisers."
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Wolfgang
full_name: Dvořák, Wolfgang
last_name: Dvořák
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
citation:
ama: 'Dvořák W, Henzinger MH. Online ad assignment with an ad exchange. In: 12th
International Workshop of Approximation and Online Algorithms. Vol 8952. Springer
Nature; 2015:156–167. doi:10.1007/978-3-319-18263-6_14'
apa: 'Dvořák, W., & Henzinger, M. H. (2015). Online ad assignment with an ad
exchange. In 12th International Workshop of Approximation and Online Algorithms
(Vol. 8952, pp. 156–167). Wroclaw, Poland: Springer Nature. https://doi.org/10.1007/978-3-319-18263-6_14'
chicago: Dvořák, Wolfgang, and Monika H Henzinger. “Online Ad Assignment with an
Ad Exchange.” In 12th International Workshop of Approximation and Online Algorithms,
8952:156–167. Springer Nature, 2015. https://doi.org/10.1007/978-3-319-18263-6_14.
ieee: W. Dvořák and M. H. Henzinger, “Online ad assignment with an ad exchange,”
in 12th International Workshop of Approximation and Online Algorithms,
Wroclaw, Poland, 2015, vol. 8952, pp. 156–167.
ista: 'Dvořák W, Henzinger MH. 2015. Online ad assignment with an ad exchange. 12th
International Workshop of Approximation and Online Algorithms. WAOA: International
Workshop on Approximation and Online Algorithms, LNCS, vol. 8952, 156–167.'
mla: Dvořák, Wolfgang, and Monika H. Henzinger. “Online Ad Assignment with an Ad
Exchange.” 12th International Workshop of Approximation and Online Algorithms,
vol. 8952, Springer Nature, 2015, pp. 156–167, doi:10.1007/978-3-319-18263-6_14.
short: W. Dvořák, M.H. Henzinger, in:, 12th International Workshop of Approximation
and Online Algorithms, Springer Nature, 2015, pp. 156–167.
conference:
end_date: 2014-09-12
location: Wroclaw, Poland
name: 'WAOA: International Workshop on Approximation and Online Algorithms'
start_date: 2014-09-11
date_created: 2022-08-11T09:43:32Z
date_published: 2015-01-01T00:00:00Z
date_updated: 2023-02-10T09:26:06Z
day: '01'
doi: 10.1007/978-3-319-18263-6_14
extern: '1'
external_id:
arxiv:
- '1604.05603'
intvolume: ' 8952'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1604.05603
month: '01'
oa: 1
oa_version: Preprint
page: 156–167
publication: 12th International Workshop of Approximation and Online Algorithms
publication_identifier:
issn:
- 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Online ad assignment with an ad exchange
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 8952
year: '2015'
...
---
_id: '11786'
abstract:
- lang: eng
text: "In this paper, we develop a dynamic version of the primal-dual method for
optimization problems, and apply it to obtain the following results. (1) For the
dynamic set-cover problem, we maintain an \U0001D442(\U0001D4532)-approximately
optimal solution in \U0001D442(\U0001D453⋅log(\U0001D45A+\U0001D45B)) amortized
update time, where \U0001D453 is the maximum “frequency” of an element, \U0001D45B
is the number of sets, and \U0001D45A is the maximum number of elements in the
universe at any point in time. (2) For the dynamic \U0001D44F-matching problem,
we maintain an \U0001D442(1)-approximately optimal solution in \U0001D442(log3\U0001D45B)
amortized update time, where \U0001D45B is the number of nodes in the graph."
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Sayan
full_name: Bhattacharya, Sayan
last_name: Bhattacharya
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Giuseppe F.
full_name: Italiano, Giuseppe F.
last_name: Italiano
citation:
ama: 'Bhattacharya S, Henzinger MH, Italiano GF. Design of dynamic algorithms via
primal-dual method. In: 42nd International Colloquium on Automata, Languages
and Programming. Vol 9134. Springer Nature; 2015:206-218. doi:10.1007/978-3-662-47672-7_17'
apa: 'Bhattacharya, S., Henzinger, M. H., & Italiano, G. F. (2015). Design of
dynamic algorithms via primal-dual method. In 42nd International Colloquium
on Automata, Languages and Programming (Vol. 9134, pp. 206–218). Kyoto, Japan:
Springer Nature. https://doi.org/10.1007/978-3-662-47672-7_17'
chicago: Bhattacharya, Sayan, Monika H Henzinger, and Giuseppe F. Italiano. “Design
of Dynamic Algorithms via Primal-Dual Method.” In 42nd International Colloquium
on Automata, Languages and Programming, 9134:206–18. Springer Nature, 2015.
https://doi.org/10.1007/978-3-662-47672-7_17.
ieee: S. Bhattacharya, M. H. Henzinger, and G. F. Italiano, “Design of dynamic algorithms
via primal-dual method,” in 42nd International Colloquium on Automata, Languages
and Programming, Kyoto, Japan, 2015, vol. 9134, pp. 206–218.
ista: 'Bhattacharya S, Henzinger MH, Italiano GF. 2015. Design of dynamic algorithms
via primal-dual method. 42nd International Colloquium on Automata, Languages and
Programming. ICALP: International Colloquium on Automata, Languages, and Programming,
LNCS, vol. 9134, 206–218.'
mla: Bhattacharya, Sayan, et al. “Design of Dynamic Algorithms via Primal-Dual Method.”
42nd International Colloquium on Automata, Languages and Programming, vol.
9134, Springer Nature, 2015, pp. 206–18, doi:10.1007/978-3-662-47672-7_17.
short: S. Bhattacharya, M.H. Henzinger, G.F. Italiano, in:, 42nd International Colloquium
on Automata, Languages and Programming, Springer Nature, 2015, pp. 206–218.
conference:
end_date: 2015-07-10
location: Kyoto, Japan
name: 'ICALP: International Colloquium on Automata, Languages, and Programming'
start_date: 2015-07-06
date_created: 2022-08-11T09:28:49Z
date_published: 2015-01-01T00:00:00Z
date_updated: 2023-02-10T09:13:31Z
day: '01'
doi: 10.1007/978-3-662-47672-7_17
extern: '1'
external_id:
arxiv:
- '1604.05337'
intvolume: ' 9134'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1604.05337
month: '01'
oa: 1
oa_version: Preprint
page: 206 - 218
publication: 42nd International Colloquium on Automata, Languages and Programming
publication_identifier:
isbn:
- '9783662476710'
issn:
- 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Design of dynamic algorithms via primal-dual method
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 9134
year: '2015'
...
---
_id: '11845'
abstract:
- lang: eng
text: "Phylogenetic diversity (PD) is a measure of biodiversity based on the evolutionary
history of species. Here, we discuss several optimization problems related to
the use of PD, and the more general measure split diversity (SD), in conservation
prioritization.\r\nDepending on the conservation goal and the information available
about species, one can construct optimization routines that incorporate various
conservation constraints. We demonstrate how this information can be used to select
sets of species for conservation action. Specifically, we discuss the use of species'
geographic distributions, the choice of candidates under economic pressure, and
the use of predator–prey interactions between the species in a community to define
viability constraints.\r\nDespite such optimization problems falling into the
area of NP hard problems, it is possible to solve them in a reasonable amount
of time using integer programming. We apply integer linear programming to a variety
of models for conservation prioritization that incorporate the SD measure.\r\nWe
exemplarily show the results for two data sets: the Cape region of South Africa
and a Caribbean coral reef community. Finally, we provide user-friendly software
at http://www.cibiv.at/software/pda."
article_processing_charge: No
article_type: original
author:
- first_name: Olga
full_name: Chernomor, Olga
last_name: Chernomor
- first_name: Bui Quang
full_name: Minh, Bui Quang
last_name: Minh
- first_name: Félix
full_name: Forest, Félix
last_name: Forest
- first_name: Steffen
full_name: Klaere, Steffen
last_name: Klaere
- first_name: Travis
full_name: Ingram, Travis
last_name: Ingram
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Arndt
full_name: von Haeseler, Arndt
last_name: von Haeseler
citation:
ama: Chernomor O, Minh BQ, Forest F, et al. Split diversity in constrained conservation
prioritization using integer linear programming. Methods in Ecology and Evolution.
2015;6(1):83-91. doi:10.1111/2041-210x.12299
apa: Chernomor, O., Minh, B. Q., Forest, F., Klaere, S., Ingram, T., Henzinger,
M. H., & von Haeseler, A. (2015). Split diversity in constrained conservation
prioritization using integer linear programming. Methods in Ecology and Evolution.
Wiley. https://doi.org/10.1111/2041-210x.12299
chicago: Chernomor, Olga, Bui Quang Minh, Félix Forest, Steffen Klaere, Travis Ingram,
Monika H Henzinger, and Arndt von Haeseler. “Split Diversity in Constrained Conservation
Prioritization Using Integer Linear Programming.” Methods in Ecology and Evolution.
Wiley, 2015. https://doi.org/10.1111/2041-210x.12299.
ieee: O. Chernomor et al., “Split diversity in constrained conservation prioritization
using integer linear programming,” Methods in Ecology and Evolution, vol.
6, no. 1. Wiley, pp. 83–91, 2015.
ista: Chernomor O, Minh BQ, Forest F, Klaere S, Ingram T, Henzinger MH, von Haeseler
A. 2015. Split diversity in constrained conservation prioritization using integer
linear programming. Methods in Ecology and Evolution. 6(1), 83–91.
mla: Chernomor, Olga, et al. “Split Diversity in Constrained Conservation Prioritization
Using Integer Linear Programming.” Methods in Ecology and Evolution, vol.
6, no. 1, Wiley, 2015, pp. 83–91, doi:10.1111/2041-210x.12299.
short: O. Chernomor, B.Q. Minh, F. Forest, S. Klaere, T. Ingram, M.H. Henzinger,
A. von Haeseler, Methods in Ecology and Evolution 6 (2015) 83–91.
date_created: 2022-08-16T06:43:49Z
date_published: 2015-01-01T00:00:00Z
date_updated: 2023-02-17T09:30:08Z
day: '01'
ddc:
- '570'
doi: 10.1111/2041-210x.12299
extern: '1'
external_id:
pmid:
- '25893087'
file:
- access_level: open_access
checksum: 880e78f09f0ac99cb351c48dc97623b6
content_type: application/pdf
creator: asandaue
date_created: 2022-08-16T06:52:53Z
date_updated: 2022-08-16T06:52:53Z
file_id: '11846'
file_name: 2015_MethodsInEcologyAndEvolutionChernomor.pdf
file_size: 411415
relation: main_file
success: 1
file_date_updated: 2022-08-16T06:52:53Z
has_accepted_license: '1'
intvolume: ' 6'
issue: '1'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
page: 83-91
pmid: 1
publication: Methods in Ecology and Evolution
publication_identifier:
eissn:
- 2041-210X
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Split diversity in constrained conservation prioritization using integer linear
programming
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 6
year: '2015'
...
---
_id: '11868'
abstract:
- lang: eng
text: "Consider the following Online Boolean Matrix-Vector Multiplication problem:
We are given an n x n matrix M and will receive n column-vectors of size n, denoted
by v1, ..., vn, one by one. After seeing each vector vi, we have to output the
product Mvi before we can see the next vector. A naive algorithm can solve this
problem using O(n3) time in total, and its running time can be slightly improved
to O(n3/log2 n) [Williams SODA'07]. We show that a conjecture that there is no
truly subcubic (O(n3-ε)) time algorithm for this problem can be used to exhibit
the underlying polynomial time hardness shared by many dynamic problems. For a
number of problems, such as subgraph connectivity, Pagh's problem, d-failure connectivity,
decremental single-source shortest paths, and decremental transitive closure,
this conjecture implies tight hardness results. Thus, proving or disproving this
conjecture will be very interesting as it will either imply several tight unconditional
lower bounds or break through a common barrier that blocks progress with these
problems. This conjecture might also be considered as strong evidence against
any further improvement for these problems since refuting it will imply a major
breakthrough for combinatorial Boolean matrix multiplication and other long-standing
problems if the term \"combinatorial algorithms\" is interpreted as \"Strassen-like
algorithms\" [Ballard et al. SPAA'11].\r\n\r\nThe conjecture also leads to hardness
results for problems that were previously based on diverse problems and conjectures
-- such as 3SUM, combinatorial Boolean matrix multiplication, triangle detection,
and multiphase -- thus providing a uniform way to prove polynomial hardness results
for dynamic algorithms; some of the new proofs are also simpler or even become
trivial. The conjecture also leads to stronger and new, non-trivial, hardness
results, e.g., for the fully-dynamic densest subgraph and diameter problems."
article_number: 21-30
article_processing_charge: No
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Sebastian
full_name: Krinninger, Sebastian
last_name: Krinninger
- first_name: Danupon
full_name: Nanongkai, Danupon
last_name: Nanongkai
- first_name: Thatchaphol
full_name: Saranurak, Thatchaphol
last_name: Saranurak
citation:
ama: 'Henzinger MH, Krinninger S, Nanongkai D, Saranurak T. Unifying and strengthening
hardness for dynamic problems via the online matrix-vector multiplication conjecture.
In: 47th Annual ACM Symposium on Theory of Computing. Association for Computing
Machinery; 2015. doi:10.1145/2746539.2746609'
apa: 'Henzinger, M. H., Krinninger, S., Nanongkai, D., & Saranurak, T. (2015).
Unifying and strengthening hardness for dynamic problems via the online matrix-vector
multiplication conjecture. In 47th Annual ACM Symposium on Theory of Computing.
Portland, OR, United States: Association for Computing Machinery. https://doi.org/10.1145/2746539.2746609'
chicago: Henzinger, Monika H, Sebastian Krinninger, Danupon Nanongkai, and Thatchaphol
Saranurak. “Unifying and Strengthening Hardness for Dynamic Problems via the Online
Matrix-Vector Multiplication Conjecture.” In 47th Annual ACM Symposium on Theory
of Computing. Association for Computing Machinery, 2015. https://doi.org/10.1145/2746539.2746609.
ieee: M. H. Henzinger, S. Krinninger, D. Nanongkai, and T. Saranurak, “Unifying
and strengthening hardness for dynamic problems via the online matrix-vector multiplication
conjecture,” in 47th Annual ACM Symposium on Theory of Computing, Portland,
OR, United States, 2015.
ista: 'Henzinger MH, Krinninger S, Nanongkai D, Saranurak T. 2015. Unifying and
strengthening hardness for dynamic problems via the online matrix-vector multiplication
conjecture. 47th Annual ACM Symposium on Theory of Computing. STOC: Symposium
on Theory of Computing, 21–30.'
mla: Henzinger, Monika H., et al. “Unifying and Strengthening Hardness for Dynamic
Problems via the Online Matrix-Vector Multiplication Conjecture.” 47th Annual
ACM Symposium on Theory of Computing, 21–30, Association for Computing Machinery,
2015, doi:10.1145/2746539.2746609.
short: M.H. Henzinger, S. Krinninger, D. Nanongkai, T. Saranurak, in:, 47th Annual
ACM Symposium on Theory of Computing, Association for Computing Machinery, 2015.
conference:
end_date: 2015-06-17
location: Portland, OR, United States
name: 'STOC: Symposium on Theory of Computing'
start_date: 2015-06-14
date_created: 2022-08-16T09:31:21Z
date_published: 2015-06-14T00:00:00Z
date_updated: 2023-02-17T11:09:54Z
day: '14'
doi: 10.1145/2746539.2746609
extern: '1'
external_id:
arxiv:
- '1511.06773'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1511.06773
month: '06'
oa: 1
oa_version: Preprint
publication: 47th Annual ACM Symposium on Theory of Computing
publication_identifier:
isbn:
- 978-145033536-2
issn:
- '0737.8017'
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
scopus_import: '1'
status: public
title: Unifying and strengthening hardness for dynamic problems via the online matrix-vector
multiplication conjecture
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2015'
...
---
_id: '11869'
abstract:
- lang: eng
text: "While in many graph mining applications it is crucial to handle a stream
of updates efficiently in terms of both time and space, not much was known about
achieving such type of algorithm. In this paper we study this issue for a problem
which lies at the core of many graph mining applications called densest subgraph
problem. We develop an algorithm that achieves time- and space-efficiency for
this problem simultaneously. It is one of the first of its kind for graph problems
to the best of our knowledge.\r\n\r\nGiven an input graph, the densest subgraph
is the subgraph that maximizes the ratio between the number of edges and the number
of nodes. For any ε>0, our algorithm can, with high probability, maintain a (4+ε)-approximate
solution under edge insertions and deletions using ~O(n) space and ~O(1) amortized
time per update; here, $n$ is the number of nodes in the graph and ~O hides the
O(polylog_{1+ε} n) term. The approximation ratio can be improved to (2+ε) with
more time. It can be extended to a (2+ε)-approximation sublinear-time algorithm
and a distributed-streaming algorithm. Our algorithm is the first streaming algorithm
that can maintain the densest subgraph in one pass. Prior to this, no algorithm
could do so even in the special case of an incremental stream and even when there
is no time restriction. The previously best algorithm in this setting required
O(log n) passes [BahmaniKV12]. The space required by our algorithm is tight up
to a polylogarithmic factor."
article_processing_charge: No
author:
- first_name: Sayan
full_name: Bhattacharya, Sayan
last_name: Bhattacharya
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Danupon
full_name: Nanongkai, Danupon
last_name: Nanongkai
- first_name: Charalampos
full_name: Tsourakakis, Charalampos
last_name: Tsourakakis
citation:
ama: 'Bhattacharya S, Henzinger MH, Nanongkai D, Tsourakakis C. Space- and time-efficient
algorithm for maintaining dense subgraphs on one-pass dynamic streams. In: 47th
Annual ACM Symposium on Theory of Computing. Association for Computing Machinery;
2015:173-182. doi:10.1145/2746539.2746592'
apa: 'Bhattacharya, S., Henzinger, M. H., Nanongkai, D., & Tsourakakis, C. (2015).
Space- and time-efficient algorithm for maintaining dense subgraphs on one-pass
dynamic streams. In 47th Annual ACM Symposium on Theory of Computing (pp.
173–182). Portland, OR, United States: Association for Computing Machinery. https://doi.org/10.1145/2746539.2746592'
chicago: Bhattacharya, Sayan, Monika H Henzinger, Danupon Nanongkai, and Charalampos
Tsourakakis. “Space- and Time-Efficient Algorithm for Maintaining Dense Subgraphs
on One-Pass Dynamic Streams.” In 47th Annual ACM Symposium on Theory of Computing,
173–82. Association for Computing Machinery, 2015. https://doi.org/10.1145/2746539.2746592.
ieee: S. Bhattacharya, M. H. Henzinger, D. Nanongkai, and C. Tsourakakis, “Space-
and time-efficient algorithm for maintaining dense subgraphs on one-pass dynamic
streams,” in 47th Annual ACM Symposium on Theory of Computing, Portland,
OR, United States, 2015, pp. 173–182.
ista: 'Bhattacharya S, Henzinger MH, Nanongkai D, Tsourakakis C. 2015. Space- and
time-efficient algorithm for maintaining dense subgraphs on one-pass dynamic streams.
47th Annual ACM Symposium on Theory of Computing. STOC: Symposium on Theory of
Computing, 173–182.'
mla: Bhattacharya, Sayan, et al. “Space- and Time-Efficient Algorithm for Maintaining
Dense Subgraphs on One-Pass Dynamic Streams.” 47th Annual ACM Symposium on
Theory of Computing, Association for Computing Machinery, 2015, pp. 173–82,
doi:10.1145/2746539.2746592.
short: S. Bhattacharya, M.H. Henzinger, D. Nanongkai, C. Tsourakakis, in:, 47th
Annual ACM Symposium on Theory of Computing, Association for Computing Machinery,
2015, pp. 173–182.
conference:
end_date: 2015-06-17
location: Portland, OR, United States
name: 'STOC: Symposium on Theory of Computing'
start_date: 2015-06-14
date_created: 2022-08-16T09:36:48Z
date_published: 2015-06-01T00:00:00Z
date_updated: 2023-02-17T11:17:03Z
day: '01'
doi: 10.1145/2746539.2746592
extern: '1'
external_id:
arxiv:
- '1504.02268'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1504.02268
month: '06'
oa: 1
oa_version: Preprint
page: 173 - 182
publication: 47th Annual ACM Symposium on Theory of Computing
publication_identifier:
isbn:
- 978-145033536-2
issn:
- 0737-8017
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
scopus_import: '1'
status: public
title: Space- and time-efficient algorithm for maintaining dense subgraphs on one-pass
dynamic streams
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2015'
...
---
_id: '11837'
abstract:
- lang: eng
text: "Online social networks allow the collection of large amounts of data about
the influence between users connected by a friendship-like relationship. When
distributing items among agents forming a social network, this information allows
us to exploit network externalities that each agent receives from his neighbors
that get the same item. In this paper we consider Friends-of-Friends (2-hop) network
externalities, i.e., externalities that not only depend on the neighbors that
get the same item but also on neighbors of neighbors. For these externalities
we study a setting where multiple different items are assigned to unit-demand
agents. Specifically, we study the problem of welfare maximization under different
types of externality functions. Let n be the number of agents and m be the number
of items. Our contributions are the following: (1) We show that welfare maximization
is APX-hard; we show that even for step functions with 2-hop (and also with 1-hop)
externalities it is NP-hard to approximate social welfare better than (1-1/e).
(2) On the positive side we present (i) an O(sqrt n)-approximation algorithm for
general concave externality functions,\r\n(ii) an O(\\log m)-approximation algorithm
for linear externality functions, and (iii) an (1-1/e)\\frac{1}{6}-approximation
algorithm for 2-hop step function externalities. We also improve the result from
[6] for 1-hop step function externalities by giving a (1-1/e)/2-approximation
algorithm."
alternative_title:
- LIPIcs
article_processing_charge: No
author:
- first_name: Sayan
full_name: Bhattacharya, Sayan
last_name: Bhattacharya
- first_name: Wolfgang
full_name: Dvorák, Wolfgang
last_name: Dvorák
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: ' Martin'
full_name: Starnberger, Martin
last_name: Starnberger
citation:
ama: 'Bhattacharya S, Dvorák W, Henzinger MH, Starnberger Martin. Welfare maximization
with friends-of-friends network externalities. In: 32nd International Symposium
on Theoretical Aspects of Computer Science. Vol 30. Schloss Dagstuhl - Leibniz-Zentrum
für Informatik; 2015:90-102. doi:10.4230/LIPICS.STACS.2015.90'
apa: 'Bhattacharya, S., Dvorák, W., Henzinger, M. H., & Starnberger, Martin.
(2015). Welfare maximization with friends-of-friends network externalities. In
32nd International Symposium on Theoretical Aspects of Computer Science
(Vol. 30, pp. 90–102). Garching, Germany: Schloss Dagstuhl - Leibniz-Zentrum für
Informatik. https://doi.org/10.4230/LIPICS.STACS.2015.90'
chicago: Bhattacharya, Sayan, Wolfgang Dvorák, Monika H Henzinger, and Martin Starnberger.
“Welfare Maximization with Friends-of-Friends Network Externalities.” In 32nd
International Symposium on Theoretical Aspects of Computer Science, 30:90–102.
Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2015. https://doi.org/10.4230/LIPICS.STACS.2015.90.
ieee: S. Bhattacharya, W. Dvorák, M. H. Henzinger, and Martin Starnberger, “Welfare
maximization with friends-of-friends network externalities,” in 32nd International
Symposium on Theoretical Aspects of Computer Science, Garching, Germany, 2015,
vol. 30, pp. 90–102.
ista: 'Bhattacharya S, Dvorák W, Henzinger MH, Starnberger Martin. 2015. Welfare
maximization with friends-of-friends network externalities. 32nd International
Symposium on Theoretical Aspects of Computer Science. STACS: Symposium on Theoretical
Aspects of Computer Science, LIPIcs, vol. 30, 90–102.'
mla: Bhattacharya, Sayan, et al. “Welfare Maximization with Friends-of-Friends Network
Externalities.” 32nd International Symposium on Theoretical Aspects of Computer
Science, vol. 30, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2015,
pp. 90–102, doi:10.4230/LIPICS.STACS.2015.90.
short: S. Bhattacharya, W. Dvorák, M.H. Henzinger, Martin Starnberger, in:, 32nd
International Symposium on Theoretical Aspects of Computer Science, Schloss Dagstuhl
- Leibniz-Zentrum für Informatik, 2015, pp. 90–102.
conference:
end_date: 2015-03-07
location: Garching, Germany
name: 'STACS: Symposium on Theoretical Aspects of Computer Science'
start_date: 2015-03-04
date_created: 2022-08-12T11:39:40Z
date_published: 2015-02-26T00:00:00Z
date_updated: 2023-02-21T16:32:37Z
day: '26'
doi: 10.4230/LIPICS.STACS.2015.90
extern: '1'
intvolume: ' 30'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.4230/LIPICS.STACS.2015.90
month: '02'
oa: 1
oa_version: Published Version
page: 90-102
publication: 32nd International Symposium on Theoretical Aspects of Computer Science
publication_identifier:
isbn:
- 978-3-939897-78-1
issn:
- 1868-8969
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
quality_controlled: '1'
related_material:
record:
- id: '11903'
relation: later_version
status: public
scopus_import: '1'
status: public
title: Welfare maximization with friends-of-friends network externalities
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 30
year: '2015'
...
---
_id: '11901'
abstract:
- lang: eng
text: We consider auctions of indivisible items to unit-demand bidders with budgets.
This setting was suggested as an expressive model for single sponsored search
auctions. Prior work presented mechanisms that compute bidder-optimal outcomes
and are truthful for a restricted set of inputs, i.e., inputs in so-called general
position. This condition is easily violated. We provide the first mechanism that
is truthful in expectation for all inputs and achieves for each bidder no worse
utility than the bidder-optimal outcome. Additionally we give a complete characterization
for which inputs mechanisms that compute bidder-optimal outcomes are truthful.
article_processing_charge: No
article_type: original
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Veronika
full_name: Loitzenbauer, Veronika
last_name: Loitzenbauer
citation:
ama: Henzinger MH, Loitzenbauer V. Truthful unit-demand auctions with budgets revisited.
Theoretical Computer Science. 2015;573:1-15. doi:10.1016/j.tcs.2015.01.033
apa: Henzinger, M. H., & Loitzenbauer, V. (2015). Truthful unit-demand auctions
with budgets revisited. Theoretical Computer Science. Elsevier. https://doi.org/10.1016/j.tcs.2015.01.033
chicago: Henzinger, Monika H, and Veronika Loitzenbauer. “Truthful Unit-Demand Auctions
with Budgets Revisited.” Theoretical Computer Science. Elsevier, 2015.
https://doi.org/10.1016/j.tcs.2015.01.033.
ieee: M. H. Henzinger and V. Loitzenbauer, “Truthful unit-demand auctions with budgets
revisited,” Theoretical Computer Science, vol. 573. Elsevier, pp. 1–15,
2015.
ista: Henzinger MH, Loitzenbauer V. 2015. Truthful unit-demand auctions with budgets
revisited. Theoretical Computer Science. 573, 1–15.
mla: Henzinger, Monika H., and Veronika Loitzenbauer. “Truthful Unit-Demand Auctions
with Budgets Revisited.” Theoretical Computer Science, vol. 573, Elsevier,
2015, pp. 1–15, doi:10.1016/j.tcs.2015.01.033.
short: M.H. Henzinger, V. Loitzenbauer, Theoretical Computer Science 573 (2015)
1–15.
date_created: 2022-08-17T09:06:53Z
date_published: 2015-03-30T00:00:00Z
date_updated: 2023-02-17T14:50:04Z
day: '30'
doi: 10.1016/j.tcs.2015.01.033
extern: '1'
intvolume: ' 573'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.tcs.2015.01.033
month: '03'
oa: 1
oa_version: None
page: 1-15
publication: Theoretical Computer Science
publication_identifier:
issn:
- 0304-3975
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Truthful unit-demand auctions with budgets revisited
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 573
year: '2015'
...
---
_id: '11962'
abstract:
- lang: eng
text: One of the rare alternative reagents for the reduction of carbon–carbon double
bonds is diimide (HNNH), which can be generated in situ from hydrazine hydrate
(N2H4⋅H2O) and O2. Although this selective method is extremely clean and powerful,
it is rarely used, as the rate-determining oxidation of hydrazine in the absence
of a catalyst is relatively slow using conventional batch protocols. A continuous
high-temperature/high-pressure methodology dramatically enhances the initial oxidation
step, at the same time allowing for a safe and scalable processing of the hazardous
reaction mixture. Simple alkenes can be selectively reduced within 10–20 min at
100–120 °C and 20 bar O2 pressure. The development of a multi-injection reactor
platform for the periodic addition of N2H4⋅H2O enables the reduction of less reactive
olefins even at lower reaction temperatures. This concept was utilized for the
highly selective reduction of artemisinic acid to dihydroartemisinic acid, the
precursor molecule for the semisynthesis of the antimalarial drug artemisinin.
The industrially relevant reduction was achieved by using four consecutive liquid
feeds (of N2H4⋅H2O) and residence time units resulting in a highly selective reduction
within approximately 40 min at 60 °C and 20 bar O2 pressure, providing dihydroartemisinic
acid in ≥93 % yield and ≥95 % selectivity.
article_processing_charge: No
article_type: original
author:
- first_name: Bartholomäus
full_name: Pieber, Bartholomäus
id: 93e5e5b2-0da6-11ed-8a41-af589a024726
last_name: Pieber
orcid: 0000-0001-8689-388X
- first_name: Toma
full_name: Glasnov, Toma
last_name: Glasnov
- first_name: C. Oliver
full_name: Kappe, C. Oliver
last_name: Kappe
citation:
ama: Pieber B, Glasnov T, Kappe CO. Continuous flow reduction of artemisinic acid
utilizing multi-injection strategies-closing the gap towards a fully continuous
synthesis of antimalarial drugs. Chemistry - A European Journal. 2015;21(11):4368-4376.
doi:10.1002/chem.201406439
apa: Pieber, B., Glasnov, T., & Kappe, C. O. (2015). Continuous flow reduction
of artemisinic acid utilizing multi-injection strategies-closing the gap towards
a fully continuous synthesis of antimalarial drugs. Chemistry - A European
Journal. Wiley. https://doi.org/10.1002/chem.201406439
chicago: Pieber, Bartholomäus, Toma Glasnov, and C. Oliver Kappe. “Continuous Flow
Reduction of Artemisinic Acid Utilizing Multi-Injection Strategies-Closing the
Gap towards a Fully Continuous Synthesis of Antimalarial Drugs.” Chemistry
- A European Journal. Wiley, 2015. https://doi.org/10.1002/chem.201406439.
ieee: B. Pieber, T. Glasnov, and C. O. Kappe, “Continuous flow reduction of artemisinic
acid utilizing multi-injection strategies-closing the gap towards a fully continuous
synthesis of antimalarial drugs,” Chemistry - A European Journal, vol.
21, no. 11. Wiley, pp. 4368–4376, 2015.
ista: Pieber B, Glasnov T, Kappe CO. 2015. Continuous flow reduction of artemisinic
acid utilizing multi-injection strategies-closing the gap towards a fully continuous
synthesis of antimalarial drugs. Chemistry - A European Journal. 21(11), 4368–4376.
mla: Pieber, Bartholomäus, et al. “Continuous Flow Reduction of Artemisinic Acid
Utilizing Multi-Injection Strategies-Closing the Gap towards a Fully Continuous
Synthesis of Antimalarial Drugs.” Chemistry - A European Journal, vol.
21, no. 11, Wiley, 2015, pp. 4368–76, doi:10.1002/chem.201406439.
short: B. Pieber, T. Glasnov, C.O. Kappe, Chemistry - A European Journal 21 (2015)
4368–4376.
date_created: 2022-08-24T11:11:10Z
date_published: 2015-03-09T00:00:00Z
date_updated: 2023-02-21T10:09:30Z
day: '09'
doi: 10.1002/chem.201406439
extern: '1'
external_id:
pmid:
- '25655090'
intvolume: ' 21'
issue: '11'
language:
- iso: eng
month: '03'
oa_version: None
page: 4368-4376
pmid: 1
publication: Chemistry - A European Journal
publication_identifier:
eissn:
- 1521-3765
issn:
- 0947-6539
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Continuous flow reduction of artemisinic acid utilizing multi-injection strategies-closing
the gap towards a fully continuous synthesis of antimalarial drugs
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 21
year: '2015'
...
---
_id: '11977'
abstract:
- lang: eng
text: The development of a continuous flow multistep strategy for the synthesis
of linear peptoids and their subsequent macrocyclization via Click chemistry is
described. The central transformation of this process is an Ugi four-component
reaction generating the peptidomimetic core structure. In order to avoid exposure
to the often toxic and malodorous isocyanide building blocks, the continuous approach
was telescoped by the dehydration of the corresponding formamide. In a concurrent
operation, the highly energetic azide moiety required for the subsequent intramolecular
copper-catalyzed azide–alkyne cycloaddition (Click reaction) was installed by
nucleophilic substitution from a bromide precursor. All steps yielding to the
linear core structures can be conveniently coupled without the need for purification
steps resulting in a single process generating the desired peptidomimetics in
good to excellent yields within a 25 min reaction time. The following macrocyclization
was realized in a coil reactor made of copper without any additional additive.
A careful process intensification study demonstrated that this transformation
occurs quantitatively within 25 min at 140 °C. Depending on the resulting ring
strain, either a dimeric or a monomeric form of the cyclic product was obtained.
article_processing_charge: No
article_type: original
author:
- first_name: Carlos Eduardo M.
full_name: Salvador, Carlos Eduardo M.
last_name: Salvador
- first_name: Bartholomäus
full_name: Pieber, Bartholomäus
id: 93e5e5b2-0da6-11ed-8a41-af589a024726
last_name: Pieber
orcid: 0000-0001-8689-388X
- first_name: Philipp M.
full_name: Neu, Philipp M.
last_name: Neu
- first_name: Ana
full_name: Torvisco, Ana
last_name: Torvisco
- first_name: Carlos
full_name: Kleber Z. Andrade, Carlos
last_name: Kleber Z. Andrade
- first_name: C. Oliver
full_name: Kappe, C. Oliver
last_name: Kappe
citation:
ama: Salvador CEM, Pieber B, Neu PM, Torvisco A, Kleber Z. Andrade C, Kappe CO.
A sequential Ugi multicomponent/Cu-catalyzed azide–alkyne cycloaddition approach
for the continuous flow generation of cyclic peptoids. The Journal of Organic
Chemistry. 2015;80(9):4590-4602. doi:10.1021/acs.joc.5b00445
apa: Salvador, C. E. M., Pieber, B., Neu, P. M., Torvisco, A., Kleber Z. Andrade,
C., & Kappe, C. O. (2015). A sequential Ugi multicomponent/Cu-catalyzed azide–alkyne
cycloaddition approach for the continuous flow generation of cyclic peptoids.
The Journal of Organic Chemistry. American Chemical Society. https://doi.org/10.1021/acs.joc.5b00445
chicago: Salvador, Carlos Eduardo M., Bartholomäus Pieber, Philipp M. Neu, Ana Torvisco,
Carlos Kleber Z. Andrade, and C. Oliver Kappe. “A Sequential Ugi Multicomponent/Cu-Catalyzed
Azide–Alkyne Cycloaddition Approach for the Continuous Flow Generation of Cyclic
Peptoids.” The Journal of Organic Chemistry. American Chemical Society,
2015. https://doi.org/10.1021/acs.joc.5b00445.
ieee: C. E. M. Salvador, B. Pieber, P. M. Neu, A. Torvisco, C. Kleber Z. Andrade,
and C. O. Kappe, “A sequential Ugi multicomponent/Cu-catalyzed azide–alkyne cycloaddition
approach for the continuous flow generation of cyclic peptoids,” The Journal
of Organic Chemistry, vol. 80, no. 9. American Chemical Society, pp. 4590–4602,
2015.
ista: Salvador CEM, Pieber B, Neu PM, Torvisco A, Kleber Z. Andrade C, Kappe CO.
2015. A sequential Ugi multicomponent/Cu-catalyzed azide–alkyne cycloaddition
approach for the continuous flow generation of cyclic peptoids. The Journal of
Organic Chemistry. 80(9), 4590–4602.
mla: Salvador, Carlos Eduardo M., et al. “A Sequential Ugi Multicomponent/Cu-Catalyzed
Azide–Alkyne Cycloaddition Approach for the Continuous Flow Generation of Cyclic
Peptoids.” The Journal of Organic Chemistry, vol. 80, no. 9, American Chemical
Society, 2015, pp. 4590–602, doi:10.1021/acs.joc.5b00445.
short: C.E.M. Salvador, B. Pieber, P.M. Neu, A. Torvisco, C. Kleber Z. Andrade,
C.O. Kappe, The Journal of Organic Chemistry 80 (2015) 4590–4602.
date_created: 2022-08-25T10:52:24Z
date_published: 2015-05-01T00:00:00Z
date_updated: 2023-02-21T10:10:04Z
day: '01'
doi: 10.1021/acs.joc.5b00445
extern: '1'
external_id:
pmid:
- '25842982'
intvolume: ' 80'
issue: '9'
language:
- iso: eng
month: '05'
oa_version: None
page: 4590-4602
pmid: 1
publication: The Journal of Organic Chemistry
publication_identifier:
eissn:
- 1520-6904
issn:
- 0022-3263
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: A sequential Ugi multicomponent/Cu-catalyzed azide–alkyne cycloaddition approach
for the continuous flow generation of cyclic peptoids
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 80
year: '2015'
...
---
_id: '11989'
abstract:
- lang: eng
text: In recent years, the high demand for sustainable processes resulted in the
development of highly attractive oxidation protocols utilizing molecular oxygen
or even air instead of more uneconomic and often toxic reagents. The application
of these sustainable, gaseous oxidants in conventional batch reactors is often
associated with severe safety risks and process challenges especially on larger
scales. Continuous flow technology offers the possibility to minimize these safety
hazards and concurrently allows working in high-temperature/high-pressure regimes
to access highly efficient oxidation protocols. This review article critically
discusses recent literature examples of flow methodologies for selective aerobic
oxidations of organic compounds. Several technologies and reactor designs for
biphasic gas/liquid as well as supercritical reaction media are presented in detail.
© Springer International Publishing Switzerland 2015.
alternative_title:
- Topics in Organometallic Chemistry
article_processing_charge: No
author:
- first_name: Bartholomäus
full_name: Pieber, Bartholomäus
id: 93e5e5b2-0da6-11ed-8a41-af589a024726
last_name: Pieber
orcid: 0000-0001-8689-388X
- first_name: C. Oliver
full_name: Kappe, C. Oliver
last_name: Kappe
citation:
ama: 'Pieber B, Kappe CO. Aerobic oxidations in continuous flow. In: Noël T, ed.
Organometallic Flow Chemistry. Vol 57. 1st ed. TOPORGAN. Cham: Springer
Nature; 2015:97–136. doi:10.1007/3418_2015_133'
apa: 'Pieber, B., & Kappe, C. O. (2015). Aerobic oxidations in continuous flow.
In T. Noël (Ed.), Organometallic Flow Chemistry (1st ed., Vol. 57, pp.
97–136). Cham: Springer Nature. https://doi.org/10.1007/3418_2015_133'
chicago: 'Pieber, Bartholomäus, and C. Oliver Kappe. “Aerobic Oxidations in Continuous
Flow.” In Organometallic Flow Chemistry, edited by Timothy Noël, 1st ed.,
57:97–136. TOPORGAN. Cham: Springer Nature, 2015. https://doi.org/10.1007/3418_2015_133.'
ieee: 'B. Pieber and C. O. Kappe, “Aerobic oxidations in continuous flow,” in Organometallic
Flow Chemistry, 1st ed., vol. 57, T. Noël, Ed. Cham: Springer Nature, 2015,
pp. 97–136.'
ista: 'Pieber B, Kappe CO. 2015.Aerobic oxidations in continuous flow. In: Organometallic
Flow Chemistry. Topics in Organometallic Chemistry, vol. 57, 97–136.'
mla: Pieber, Bartholomäus, and C. Oliver Kappe. “Aerobic Oxidations in Continuous
Flow.” Organometallic Flow Chemistry, edited by Timothy Noël, 1st ed.,
vol. 57, Springer Nature, 2015, pp. 97–136, doi:10.1007/3418_2015_133.
short: B. Pieber, C.O. Kappe, in:, T. Noël (Ed.), Organometallic Flow Chemistry,
1st ed., Springer Nature, Cham, 2015, pp. 97–136.
date_created: 2022-08-25T11:58:38Z
date_published: 2015-06-10T00:00:00Z
date_updated: 2023-02-21T10:10:35Z
day: '10'
doi: 10.1007/3418_2015_133
edition: '1'
editor:
- first_name: Timothy
full_name: Noël, Timothy
last_name: Noël
extern: '1'
intvolume: ' 57'
language:
- iso: eng
month: '06'
oa_version: None
page: 97–136
place: Cham
publication: Organometallic Flow Chemistry
publication_identifier:
eisbn:
- '9783319332437'
eissn:
- 1616-8534
isbn:
- '9783319332413'
issn:
- 1436-6002
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
series_title: TOPORGAN
status: public
title: Aerobic oxidations in continuous flow
type: book_chapter
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 57
year: '2015'
...
---
_id: '120'
abstract:
- lang: eng
text: Clustering of fine particles is of crucial importance in settings ranging
from the early stages of planet formation to the coagulation of industrial powders
and airborne pollutants. Models of such clustering typically focus on inelastic
deformation and cohesion. However, even in charge-neutral particle systems comprising
grains of the same dielectric material, tribocharging can generate large amounts
of net positive or negative charge on individual particles, resulting in long-range
electrostatic forces. The effects of such forces on cluster formation are not
well understood and have so far not been studied in situ. Here we report the first
observations of individual collide-and-capture events between charged submillimetre
particles, including Kepler-like orbits. Charged particles can become trapped
in their mutual electrostatic energy well and aggregate via multiple bounces.
This enables the initiation of clustering at relative velocities much larger than
the upper limit for sticking after a head-on collision, a long-standing issue
known from pre-planetary dust aggregation. Moreover, Coulomb interactions together
with dielectric polarization are found to stabilize characteristic molecule-like
configurations, providing new insights for the modelling of clustering dynamics
in a wide range of microscopic dielectric systems, such as charged polarizable
ions, biomolecules and colloids.
acknowledgement: This research was supported by NSF through DMR-1309611. The Chicago
MRSEC, supported by NSF DMR-1420709, is gratefully acknowledged for access to its
shared experimental facilities.
author:
- first_name: Victor
full_name: Lee, Victor
last_name: Lee
- first_name: Scott R
full_name: Waitukaitis, Scott R
id: 3A1FFC16-F248-11E8-B48F-1D18A9856A87
last_name: Waitukaitis
orcid: 0000-0002-2299-3176
- first_name: Marc
full_name: Miskin, Marc
last_name: Miskin
- first_name: Heinrich
full_name: Jaeger, Heinrich
last_name: Jaeger
citation:
ama: Lee V, Waitukaitis SR, Miskin M, Jaeger H. Direct observation of particle interactions
and clustering in charged granular streams. Nature Physics. 2015;11(9):733-737.
doi:10.1038/nphys3396
apa: Lee, V., Waitukaitis, S. R., Miskin, M., & Jaeger, H. (2015). Direct observation
of particle interactions and clustering in charged granular streams. Nature
Physics. Nature Publishing Group. https://doi.org/10.1038/nphys3396
chicago: Lee, Victor, Scott R Waitukaitis, Marc Miskin, and Heinrich Jaeger. “Direct
Observation of Particle Interactions and Clustering in Charged Granular Streams.”
Nature Physics. Nature Publishing Group, 2015. https://doi.org/10.1038/nphys3396.
ieee: V. Lee, S. R. Waitukaitis, M. Miskin, and H. Jaeger, “Direct observation of
particle interactions and clustering in charged granular streams,” Nature Physics,
vol. 11, no. 9. Nature Publishing Group, pp. 733–737, 2015.
ista: Lee V, Waitukaitis SR, Miskin M, Jaeger H. 2015. Direct observation of particle
interactions and clustering in charged granular streams. Nature Physics. 11(9),
733–737.
mla: Lee, Victor, et al. “Direct Observation of Particle Interactions and Clustering
in Charged Granular Streams.” Nature Physics, vol. 11, no. 9, Nature Publishing
Group, 2015, pp. 733–37, doi:10.1038/nphys3396.
short: V. Lee, S.R. Waitukaitis, M. Miskin, H. Jaeger, Nature Physics 11 (2015)
733–737.
date_created: 2018-12-11T11:44:44Z
date_published: 2015-07-13T00:00:00Z
date_updated: 2021-01-12T06:49:02Z
day: '13'
doi: 10.1038/nphys3396
extern: '1'
intvolume: ' 11'
issue: '9'
language:
- iso: eng
month: '07'
oa_version: None
page: 733 - 737
publication: Nature Physics
publication_status: published
publisher: Nature Publishing Group
publist_id: '7934'
quality_controlled: '1'
status: public
title: Direct observation of particle interactions and clustering in charged granular
streams
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 11
year: '2015'
...
---
_id: '121'
abstract:
- lang: eng
text: We show that the simplest building blocks of origami-based materials - rigid,
degree-four vertices - are generically multistable. The existence of two distinct
branches of folding motion emerging from the flat state suggests at least bistability,
but we show how nonlinearities in the folding motions allow generic vertex geometries
to have as many as five stable states. In special geometries with collinear folds
and symmetry, more branches emerge leading to as many as six stable states. Tuning
the fold energy parameters, we show how monostability is also possible. Finally,
we show how to program the stability features of a single vertex into a periodic
fold tessellation. The resulting metasheets provide a previously unanticipated
functionality - tunable and switchable shape and size via multistability.
acknowledgement: B. G. C. acknowledges support from FOM, and S. W. and M. v. H. acknowledge
support from NWO.
article_number: '055503'
author:
- first_name: Scott R
full_name: Waitukaitis, Scott R
id: 3A1FFC16-F248-11E8-B48F-1D18A9856A87
last_name: Waitukaitis
orcid: 0000-0002-2299-3176
- first_name: Rémi
full_name: Menaut, Rémi
last_name: Menaut
- first_name: Bryan
full_name: Chen, Bryan
last_name: Chen
- first_name: Martin
full_name: Van Hecke, Martin
last_name: Van Hecke
citation:
ama: 'Waitukaitis SR, Menaut R, Chen B, Van Hecke M. Origami multistability: From
single vertices to metasheets. APS Physics, Physical Review Letters. 2015;114(5).
doi:10.1103/PhysRevLett.114.055503'
apa: 'Waitukaitis, S. R., Menaut, R., Chen, B., & Van Hecke, M. (2015). Origami
multistability: From single vertices to metasheets. APS Physics, Physical Review
Letters. American Physical Society. https://doi.org/10.1103/PhysRevLett.114.055503'
chicago: 'Waitukaitis, Scott R, Rémi Menaut, Bryan Chen, and Martin Van Hecke. “Origami
Multistability: From Single Vertices to Metasheets.” APS Physics, Physical
Review Letters. American Physical Society, 2015. https://doi.org/10.1103/PhysRevLett.114.055503.'
ieee: 'S. R. Waitukaitis, R. Menaut, B. Chen, and M. Van Hecke, “Origami multistability:
From single vertices to metasheets,” APS Physics, Physical Review Letters,
vol. 114, no. 5. American Physical Society, 2015.'
ista: 'Waitukaitis SR, Menaut R, Chen B, Van Hecke M. 2015. Origami multistability:
From single vertices to metasheets. APS Physics, Physical Review Letters. 114(5),
055503.'
mla: 'Waitukaitis, Scott R., et al. “Origami Multistability: From Single Vertices
to Metasheets.” APS Physics, Physical Review Letters, vol. 114, no. 5,
055503, American Physical Society, 2015, doi:10.1103/PhysRevLett.114.055503.'
short: S.R. Waitukaitis, R. Menaut, B. Chen, M. Van Hecke, APS Physics, Physical
Review Letters 114 (2015).
date_created: 2018-12-11T11:44:44Z
date_published: 2015-02-04T00:00:00Z
date_updated: 2021-01-12T06:49:07Z
day: '04'
doi: 10.1103/PhysRevLett.114.055503
extern: '1'
external_id:
arxiv:
- '1408.1607'
intvolume: ' 114'
issue: '5'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1408.1607
month: '02'
oa: 1
oa_version: Preprint
publication: APS Physics, Physical Review Letters
publication_status: published
publisher: American Physical Society
publist_id: '7933'
quality_controlled: '1'
status: public
title: 'Origami multistability: From single vertices to metasheets'
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 114
year: '2015'
...
---
_id: '1311'
abstract:
- lang: eng
text: In this paper, we develop an energy method to study finite speed of propagation
and waiting time phenomena for the stochastic porous media equation with linear
multiplicative noise in up to three spatial dimensions. Based on a novel iteration
technique and on stochastic counterparts of weighted integral estimates used in
the deterministic setting, we formulate a sufficient criterion on the growth of
initial data which locally guarantees a waiting time phenomenon to occur almost
surely. Up to a logarithmic factor, this criterion coincides with the optimal
criterion known from the deterministic setting. Our technique can be modified
to prove finite speed of propagation as well.
acknowledgement: The first author has been supported by the Lithuanian-Swiss co- operation
program under the project agreement No. CH-SMM-01/0.
author:
- first_name: Julian L
full_name: Julian Fischer
id: 2C12A0B0-F248-11E8-B48F-1D18A9856A87
last_name: Fischer
orcid: 0000-0002-0479-558X
- first_name: Günther
full_name: Grün, Günther
last_name: Grün
citation:
ama: 'Fischer JL, Grün G. Finite speed of propagation and waiting times for the
stochastic porous medium equation: A unifying approach. SIAM Journal on Mathematical
Analysis. 2015;47(1):825-854. doi:10.1137/140960578'
apa: 'Fischer, J. L., & Grün, G. (2015). Finite speed of propagation and waiting
times for the stochastic porous medium equation: A unifying approach. SIAM
Journal on Mathematical Analysis. Society for Industrial and Applied Mathematics
. https://doi.org/10.1137/140960578'
chicago: 'Fischer, Julian L, and Günther Grün. “Finite Speed of Propagation and
Waiting Times for the Stochastic Porous Medium Equation: A Unifying Approach.”
SIAM Journal on Mathematical Analysis. Society for Industrial and Applied
Mathematics , 2015. https://doi.org/10.1137/140960578.'
ieee: 'J. L. Fischer and G. Grün, “Finite speed of propagation and waiting times
for the stochastic porous medium equation: A unifying approach,” SIAM Journal
on Mathematical Analysis, vol. 47, no. 1. Society for Industrial and Applied
Mathematics , pp. 825–854, 2015.'
ista: 'Fischer JL, Grün G. 2015. Finite speed of propagation and waiting times for
the stochastic porous medium equation: A unifying approach. SIAM Journal on Mathematical
Analysis. 47(1), 825–854.'
mla: 'Fischer, Julian L., and Günther Grün. “Finite Speed of Propagation and Waiting
Times for the Stochastic Porous Medium Equation: A Unifying Approach.” SIAM
Journal on Mathematical Analysis, vol. 47, no. 1, Society for Industrial and
Applied Mathematics , 2015, pp. 825–54, doi:10.1137/140960578.'
short: J.L. Fischer, G. Grün, SIAM Journal on Mathematical Analysis 47 (2015) 825–854.
date_created: 2018-12-11T11:51:18Z
date_published: 2015-01-01T00:00:00Z
date_updated: 2021-01-12T06:49:48Z
day: '01'
doi: 10.1137/140960578
extern: 1
intvolume: ' 47'
issue: '1'
month: '01'
page: 825 - 854
publication: SIAM Journal on Mathematical Analysis
publication_status: published
publisher: 'Society for Industrial and Applied Mathematics '
publist_id: '5958'
quality_controlled: 0
status: public
title: 'Finite speed of propagation and waiting times for the stochastic porous medium
equation: A unifying approach'
type: journal_article
volume: 47
year: '2015'
...
---
_id: '1314'
abstract:
- lang: eng
text: 'We derive a posteriori estimates for the modeling error caused by the assumption
of perfect incompressibility in the incompressible Navier-Stokes equation: Real
fluids are never perfectly incompressible but always feature at least some low
amount of compressibility. Thus, their behavior is described by the compressible
Navier-Stokes equation, the pressure being a steep function of the density. We
rigorously estimate the difference between an approximate solution to the incompressible
Navier-Stokes equation and any weak solution to the compressible Navier-Stokes
equation in the sense of Lions (without assuming any additional regularity of
solutions). Heuristics and numerical results suggest that our error estimates
are of optimal order in the case of "well-behaved" flows and divergence-free
approximations of the velocity field. Thus, we expect our estimates to justify
the idealization of fluids as perfectly incompressible also in practical situations.'
acknowledgement: The research of the author was supported by the Lithuanian-Swiss
cooperation program under the project agreement CH-SMM-01/0.
author:
- first_name: Julian L
full_name: Fischer, Julian L
id: 2C12A0B0-F248-11E8-B48F-1D18A9856A87
last_name: Fischer
orcid: 0000-0002-0479-558X
citation:
ama: Fischer JL. A posteriori modeling error estimates for the assumption of perfect
incompressibility in the Navier-Stokes equation. SIAM Journal on Numerical
Analysis. 2015;53(5):2178-2205. doi:10.1137/140966654
apa: Fischer, J. L. (2015). A posteriori modeling error estimates for the assumption
of perfect incompressibility in the Navier-Stokes equation. SIAM Journal on
Numerical Analysis. Society for Industrial and Applied Mathematics . https://doi.org/10.1137/140966654
chicago: Fischer, Julian L. “A Posteriori Modeling Error Estimates for the Assumption
of Perfect Incompressibility in the Navier-Stokes Equation.” SIAM Journal on
Numerical Analysis. Society for Industrial and Applied Mathematics , 2015.
https://doi.org/10.1137/140966654.
ieee: J. L. Fischer, “A posteriori modeling error estimates for the assumption of
perfect incompressibility in the Navier-Stokes equation,” SIAM Journal on Numerical
Analysis, vol. 53, no. 5. Society for Industrial and Applied Mathematics ,
pp. 2178–2205, 2015.
ista: Fischer JL. 2015. A posteriori modeling error estimates for the assumption
of perfect incompressibility in the Navier-Stokes equation. SIAM Journal on Numerical
Analysis. 53(5), 2178–2205.
mla: Fischer, Julian L. “A Posteriori Modeling Error Estimates for the Assumption
of Perfect Incompressibility in the Navier-Stokes Equation.” SIAM Journal on
Numerical Analysis, vol. 53, no. 5, Society for Industrial and Applied Mathematics
, 2015, pp. 2178–205, doi:10.1137/140966654.
short: J.L. Fischer, SIAM Journal on Numerical Analysis 53 (2015) 2178–2205.
date_created: 2018-12-11T11:51:19Z
date_published: 2015-01-01T00:00:00Z
date_updated: 2021-01-12T06:49:49Z
day: '01'
doi: 10.1137/140966654
extern: '1'
intvolume: ' 53'
issue: '5'
language:
- iso: eng
month: '01'
oa_version: None
page: 2178 - 2205
publication: SIAM Journal on Numerical Analysis
publication_status: published
publisher: 'Society for Industrial and Applied Mathematics '
publist_id: '5957'
quality_controlled: '1'
status: public
title: A posteriori modeling error estimates for the assumption of perfect incompressibility
in the Navier-Stokes equation
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 53
year: '2015'
...
---
_id: '1313'
abstract:
- lang: eng
text: We present an algorithm for the derivation of lower bounds on support propagation
for a certain class of nonlinear parabolic equations. We proceed by combining
the ideas in some recent papers by the author with the algorithmic construction
of entropies due to Jüngel and Matthes, reducing the problem to a quantifier elimination
problem. Due to its complexity, the quantifier elimination problem cannot be solved
by present exact algorithms. However, by tackling the quantifier elimination problem
numerically, in the case of the thin-film equation we are able to improve recent
results by the author in the regime of strong slippage n ∈ (1, 2). For certain
second-order doubly nonlinear parabolic equations, we are able to extend the known
lower bounds on free boundary propagation to the case of irregular oscillatory
initial data. Finally, we apply our method to a sixth-order quantum drift-diffusion
equation, resulting in an upper bound on the time which it takes for the support
to reach every point in the domain.
acknowledgement: This research was supported by the Lithuanian-Swiss cooperation program
under the project agreement No. CH-SMM-01/0.
author:
- first_name: Julian L
full_name: Julian Fischer
id: 2C12A0B0-F248-11E8-B48F-1D18A9856A87
last_name: Fischer
orcid: 0000-0002-0479-558X
citation:
ama: 'Fischer JL. Estimates on front propagation for nonlinear higher-order parabolic
equations: An algorithmic approach. Interfaces and Free Boundaries. 2015;17(1):1-20.
doi:10.4171/IFB/331'
apa: 'Fischer, J. L. (2015). Estimates on front propagation for nonlinear higher-order
parabolic equations: An algorithmic approach. Interfaces and Free Boundaries.
European Mathematical Society Publishing House. https://doi.org/10.4171/IFB/331'
chicago: 'Fischer, Julian L. “Estimates on Front Propagation for Nonlinear Higher-Order
Parabolic Equations: An Algorithmic Approach.” Interfaces and Free Boundaries.
European Mathematical Society Publishing House, 2015. https://doi.org/10.4171/IFB/331.'
ieee: 'J. L. Fischer, “Estimates on front propagation for nonlinear higher-order
parabolic equations: An algorithmic approach,” Interfaces and Free Boundaries,
vol. 17, no. 1. European Mathematical Society Publishing House, pp. 1–20, 2015.'
ista: 'Fischer JL. 2015. Estimates on front propagation for nonlinear higher-order
parabolic equations: An algorithmic approach. Interfaces and Free Boundaries.
17(1), 1–20.'
mla: 'Fischer, Julian L. “Estimates on Front Propagation for Nonlinear Higher-Order
Parabolic Equations: An Algorithmic Approach.” Interfaces and Free Boundaries,
vol. 17, no. 1, European Mathematical Society Publishing House, 2015, pp. 1–20,
doi:10.4171/IFB/331.'
short: J.L. Fischer, Interfaces and Free Boundaries 17 (2015) 1–20.
date_created: 2018-12-11T11:51:19Z
date_published: 2015-01-01T00:00:00Z
date_updated: 2021-01-12T06:49:48Z
day: '01'
doi: 10.4171/IFB/331
extern: 1
intvolume: ' 17'
issue: '1'
month: '01'
page: 1 - 20
publication: Interfaces and Free Boundaries
publication_status: published
publisher: European Mathematical Society Publishing House
publist_id: '5956'
quality_controlled: 0
status: public
title: 'Estimates on front propagation for nonlinear higher-order parabolic equations:
An algorithmic approach'
type: journal_article
volume: 17
year: '2015'
...
---
_id: '1316'
abstract:
- lang: eng
text: In the present work we introduce the notion of a renormalized solution for
reaction–diffusion systems with entropy-dissipating reactions. We establish the
global existence of renormalized solutions. In the case of integrable reaction
terms our notion of a renormalized solution reduces to the usual notion of a weak
solution. Our existence result in particular covers all reaction–diffusion systems
involving a single reversible reaction with mass-action kinetics and (possibly
species-dependent) Fick-law diffusion; more generally, it covers the case of systems
of reversible reactions with mass-action kinetics which satisfy the detailed balance
condition. For such equations the existence of any kind of solution in general
was an open problem, thereby motivating the study of renormalized solutions.
acknowledgement: This research was supported by the Lithuanian-Swiss cooperation program
under the project agreement No. CH-SMM-01/0.
author:
- first_name: Julian L
full_name: Julian Fischer
id: 2C12A0B0-F248-11E8-B48F-1D18A9856A87
last_name: Fischer
orcid: 0000-0002-0479-558X
citation:
ama: Fischer JL. Global existence of renormalized solutions to entropy-dissipating
reaction–diffusion systems. Archive for Rational Mechanics and Analysis.
2015;218(1):553-587. doi:10.1007/s00205-015-0866-x
apa: Fischer, J. L. (2015). Global existence of renormalized solutions to entropy-dissipating
reaction–diffusion systems. Archive for Rational Mechanics and Analysis.
Springer. https://doi.org/10.1007/s00205-015-0866-x
chicago: Fischer, Julian L. “Global Existence of Renormalized Solutions to Entropy-Dissipating
Reaction–Diffusion Systems.” Archive for Rational Mechanics and Analysis.
Springer, 2015. https://doi.org/10.1007/s00205-015-0866-x.
ieee: J. L. Fischer, “Global existence of renormalized solutions to entropy-dissipating
reaction–diffusion systems,” Archive for Rational Mechanics and Analysis,
vol. 218, no. 1. Springer, pp. 553–587, 2015.
ista: Fischer JL. 2015. Global existence of renormalized solutions to entropy-dissipating
reaction–diffusion systems. Archive for Rational Mechanics and Analysis. 218(1),
553–587.
mla: Fischer, Julian L. “Global Existence of Renormalized Solutions to Entropy-Dissipating
Reaction–Diffusion Systems.” Archive for Rational Mechanics and Analysis,
vol. 218, no. 1, Springer, 2015, pp. 553–87, doi:10.1007/s00205-015-0866-x.
short: J.L. Fischer, Archive for Rational Mechanics and Analysis 218 (2015) 553–587.
date_created: 2018-12-11T11:51:20Z
date_published: 2015-10-01T00:00:00Z
date_updated: 2021-01-12T06:49:50Z
day: '01'
doi: 10.1007/s00205-015-0866-x
extern: 1
intvolume: ' 218'
issue: '1'
month: '10'
page: 553 - 587
publication: Archive for Rational Mechanics and Analysis
publication_status: published
publisher: Springer
publist_id: '5955'
quality_controlled: 0
status: public
title: Global existence of renormalized solutions to entropy-dissipating reaction–diffusion
systems
type: journal_article
volume: 218
year: '2015'
...
---
_id: '1383'
abstract:
- lang: eng
text: In plants, vacuolar H+-ATPase (V-ATPase) activity acidifies both the trans-Golgi
network/early endosome (TGN/EE) and the vacuole. This dual V-ATPase function has
impeded our understanding of how the pH homeostasis within the plant TGN/EE controls
exo- and endocytosis. Here, we show that the weak V-ATPase mutant deetiolated3
(det3) displayed a pH increase in the TGN/EE, but not in the vacuole, strongly
impairing secretion and recycling of the brassinosteroid receptor and the cellulose
synthase complexes to the plasma membrane, in contrast to mutants lacking tonoplast-localized
V-ATPase activity only. The brassinosteroid insensitivity and the cellulose deficiency
defects in det3 were tightly correlated with reduced Golgi and TGN/EE motility.
Thus, our results provide strong evidence that acidification of the TGN/EE, but
not of the vacuole, is indispensable for functional secretion and recycling in
plants.
article_number: '15094'
article_processing_charge: No
article_type: original
author:
- first_name: Luo
full_name: Yu, Luo
last_name: Yu
- first_name: Stefan
full_name: Scholl, Stefan
last_name: Scholl
- first_name: Anett
full_name: Doering, Anett
last_name: Doering
- first_name: Zhang
full_name: Yi, Zhang
last_name: Yi
- first_name: Niloufer
full_name: Irani, Niloufer
last_name: Irani
- first_name: Simone
full_name: Di Rubbo, Simone
last_name: Di Rubbo
- first_name: Lutz
full_name: Neumetzler, Lutz
last_name: Neumetzler
- first_name: Praveen
full_name: Krishnamoorthy, Praveen
last_name: Krishnamoorthy
- first_name: Isabelle
full_name: Van Houtte, Isabelle
last_name: Van Houtte
- first_name: Evelien
full_name: Mylle, Evelien
last_name: Mylle
- first_name: Volker
full_name: Bischoff, Volker
last_name: Bischoff
- first_name: Samantha
full_name: Vernhettes, Samantha
last_name: Vernhettes
- first_name: Johan
full_name: Winne, Johan
last_name: Winne
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: York
full_name: Stierhof, York
last_name: Stierhof
- first_name: Karin
full_name: Schumacher, Karin
last_name: Schumacher
- first_name: Staffan
full_name: Persson, Staffan
last_name: Persson
- first_name: Eugenia
full_name: Russinova, Eugenia
last_name: Russinova
citation:
ama: Yu L, Scholl S, Doering A, et al. V-ATPase activity in the TGN/EE is required
for exocytosis and recycling in Arabidopsis. Nature Plants. 2015;1(7).
doi:10.1038/nplants.2015.94
apa: Yu, L., Scholl, S., Doering, A., Yi, Z., Irani, N., Di Rubbo, S., … Russinova,
E. (2015). V-ATPase activity in the TGN/EE is required for exocytosis and recycling
in Arabidopsis. Nature Plants. Nature Publishing Group. https://doi.org/10.1038/nplants.2015.94
chicago: Yu, Luo, Stefan Scholl, Anett Doering, Zhang Yi, Niloufer Irani, Simone
Di Rubbo, Lutz Neumetzler, et al. “V-ATPase Activity in the TGN/EE Is Required
for Exocytosis and Recycling in Arabidopsis.” Nature Plants. Nature Publishing
Group, 2015. https://doi.org/10.1038/nplants.2015.94.
ieee: L. Yu et al., “V-ATPase activity in the TGN/EE is required for exocytosis
and recycling in Arabidopsis,” Nature Plants, vol. 1, no. 7. Nature Publishing
Group, 2015.
ista: Yu L, Scholl S, Doering A, Yi Z, Irani N, Di Rubbo S, Neumetzler L, Krishnamoorthy
P, Van Houtte I, Mylle E, Bischoff V, Vernhettes S, Winne J, Friml J, Stierhof
Y, Schumacher K, Persson S, Russinova E. 2015. V-ATPase activity in the TGN/EE
is required for exocytosis and recycling in Arabidopsis. Nature Plants. 1(7),
15094.
mla: Yu, Luo, et al. “V-ATPase Activity in the TGN/EE Is Required for Exocytosis
and Recycling in Arabidopsis.” Nature Plants, vol. 1, no. 7, 15094, Nature
Publishing Group, 2015, doi:10.1038/nplants.2015.94.
short: L. Yu, S. Scholl, A. Doering, Z. Yi, N. Irani, S. Di Rubbo, L. Neumetzler,
P. Krishnamoorthy, I. Van Houtte, E. Mylle, V. Bischoff, S. Vernhettes, J. Winne,
J. Friml, Y. Stierhof, K. Schumacher, S. Persson, E. Russinova, Nature Plants
1 (2015).
date_created: 2018-12-11T11:51:42Z
date_published: 2015-07-06T00:00:00Z
date_updated: 2021-01-12T06:50:18Z
day: '06'
department:
- _id: JiFr
doi: 10.1038/nplants.2015.94
external_id:
pmid:
- '27250258'
intvolume: ' 1'
issue: '7'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905525/
month: '07'
oa: 1
oa_version: Submitted Version
pmid: 1
publication: Nature Plants
publication_status: published
publisher: Nature Publishing Group
publist_id: '5827'
quality_controlled: '1'
scopus_import: 1
status: public
title: V-ATPase activity in the TGN/EE is required for exocytosis and recycling in
Arabidopsis
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 1
year: '2015'
...
---
_id: '1425'
abstract:
- lang: eng
text: 'In this work we aim at extending the theoretical foundations of lifelong
learning. Previous work analyzing this scenario is based on the assumption that
learning tasks are sampled i.i.d. from a task environment or limited to strongly
constrained data distributions. Instead, we study two scenarios when lifelong
learning is possible, even though the observed tasks do not form an i.i.d. sample:
first, when they are sampled from the same environment, but possibly with dependencies,
and second, when the task environment is allowed to change over time in a consistent
way. In the first case we prove a PAC-Bayesian theorem that can be seen as a direct
generalization of the analogous previous result for the i.i.d. case. For the second
scenario we propose to learn an inductive bias in form of a transfer procedure.
We present a generalization bound and show on a toy example how it can be used
to identify a beneficial transfer algorithm.'
alternative_title:
- Advances in Neural Information Processing Systems
author:
- first_name: Anastasia
full_name: Pentina, Anastasia
id: 42E87FC6-F248-11E8-B48F-1D18A9856A87
last_name: Pentina
- first_name: Christoph
full_name: Lampert, Christoph
id: 40C20FD2-F248-11E8-B48F-1D18A9856A87
last_name: Lampert
orcid: 0000-0001-8622-7887
citation:
ama: 'Pentina A, Lampert C. Lifelong learning with non-i.i.d. tasks. In: Vol 2015.
Neural Information Processing Systems; 2015:1540-1548.'
apa: 'Pentina, A., & Lampert, C. (2015). Lifelong learning with non-i.i.d. tasks
(Vol. 2015, pp. 1540–1548). Presented at the NIPS: Neural Information Processing
Systems, Montreal, Canada: Neural Information Processing Systems.'
chicago: Pentina, Anastasia, and Christoph Lampert. “Lifelong Learning with Non-i.i.d.
Tasks,” 2015:1540–48. Neural Information Processing Systems, 2015.
ieee: 'A. Pentina and C. Lampert, “Lifelong learning with non-i.i.d. tasks,” presented
at the NIPS: Neural Information Processing Systems, Montreal, Canada, 2015, vol.
2015, pp. 1540–1548.'
ista: 'Pentina A, Lampert C. 2015. Lifelong learning with non-i.i.d. tasks. NIPS:
Neural Information Processing Systems, Advances in Neural Information Processing
Systems, vol. 2015, 1540–1548.'
mla: Pentina, Anastasia, and Christoph Lampert. Lifelong Learning with Non-i.i.d.
Tasks. Vol. 2015, Neural Information Processing Systems, 2015, pp. 1540–48.
short: A. Pentina, C. Lampert, in:, Neural Information Processing Systems, 2015,
pp. 1540–1548.
conference:
end_date: 2015-12-12
location: Montreal, Canada
name: 'NIPS: Neural Information Processing Systems'
start_date: 2015-12-07
date_created: 2018-12-11T11:51:57Z
date_published: 2015-01-01T00:00:00Z
date_updated: 2021-01-12T06:50:39Z
day: '01'
department:
- _id: ChLa
ec_funded: 1
intvolume: ' 2015'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://papers.nips.cc/paper/6007-lifelong-learning-with-non-iid-tasks
month: '01'
oa: 1
oa_version: None
page: 1540 - 1548
project:
- _id: 2532554C-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '308036'
name: Lifelong Learning of Visual Scene Understanding
publication_status: published
publisher: Neural Information Processing Systems
publist_id: '5781'
quality_controlled: '1'
scopus_import: 1
status: public
title: Lifelong learning with non-i.i.d. tasks
type: conference
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 2015
year: '2015'
...
---
_id: '1424'
abstract:
- lang: eng
text: We consider the problem of statistical computations with persistence diagrams,
a summary representation of topological features in data. These diagrams encode
persistent homology, a widely used invariant in topological data analysis. While
several avenues towards a statistical treatment of the diagrams have been explored
recently, we follow an alternative route that is motivated by the success of methods
based on the embedding of probability measures into reproducing kernel Hilbert
spaces. In fact, a positive definite kernel on persistence diagrams has recently
been proposed, connecting persistent homology to popular kernel-based learning
techniques such as support vector machines. However, important properties of that
kernel enabling a principled use in the context of probability measure embeddings
remain to be explored. Our contribution is to close this gap by proving universality
of a variant of the original kernel, and to demonstrate its effective use in twosample
hypothesis testing on synthetic as well as real-world data.
acknowledgement: This work was partially supported by the Austrian Science FUnd, project
no. KLI 00012.
alternative_title:
- Advances in Neural Information Processing Systems
author:
- first_name: Roland
full_name: Kwitt, Roland
last_name: Kwitt
- first_name: Stefan
full_name: Huber, Stefan
id: 4700A070-F248-11E8-B48F-1D18A9856A87
last_name: Huber
orcid: 0000-0002-8871-5814
- first_name: Marc
full_name: Niethammer, Marc
last_name: Niethammer
- first_name: Weili
full_name: Lin, Weili
last_name: Lin
- first_name: Ulrich
full_name: Bauer, Ulrich
id: 2ADD483A-F248-11E8-B48F-1D18A9856A87
last_name: Bauer
orcid: 0000-0002-9683-0724
citation:
ama: 'Kwitt R, Huber S, Niethammer M, Lin W, Bauer U. Statistical topological data
analysis-A kernel perspective. In: Vol 28. Neural Information Processing Systems;
2015:3070-3078.'
apa: 'Kwitt, R., Huber, S., Niethammer, M., Lin, W., & Bauer, U. (2015). Statistical
topological data analysis-A kernel perspective (Vol. 28, pp. 3070–3078). Presented
at the NIPS: Neural Information Processing Systems, Montreal, Canada: Neural Information
Processing Systems.'
chicago: Kwitt, Roland, Stefan Huber, Marc Niethammer, Weili Lin, and Ulrich Bauer.
“Statistical Topological Data Analysis-A Kernel Perspective,” 28:3070–78. Neural
Information Processing Systems, 2015.
ieee: 'R. Kwitt, S. Huber, M. Niethammer, W. Lin, and U. Bauer, “Statistical topological
data analysis-A kernel perspective,” presented at the NIPS: Neural Information
Processing Systems, Montreal, Canada, 2015, vol. 28, pp. 3070–3078.'
ista: 'Kwitt R, Huber S, Niethammer M, Lin W, Bauer U. 2015. Statistical topological
data analysis-A kernel perspective. NIPS: Neural Information Processing Systems,
Advances in Neural Information Processing Systems, vol. 28, 3070–3078.'
mla: Kwitt, Roland, et al. Statistical Topological Data Analysis-A Kernel Perspective.
Vol. 28, Neural Information Processing Systems, 2015, pp. 3070–78.
short: R. Kwitt, S. Huber, M. Niethammer, W. Lin, U. Bauer, in:, Neural Information
Processing Systems, 2015, pp. 3070–3078.
conference:
end_date: 2015-12-12
location: Montreal, Canada
name: 'NIPS: Neural Information Processing Systems'
start_date: 2015-12-07
date_created: 2018-12-11T11:51:56Z
date_published: 2015-12-01T00:00:00Z
date_updated: 2021-01-12T06:50:38Z
day: '01'
department:
- _id: HeEd
intvolume: ' 28'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://papers.nips.cc/paper/5887-statistical-topological-data-analysis-a-kernel-perspective
month: '12'
oa: 1
oa_version: Submitted Version
page: 3070 - 3078
publication_status: published
publisher: Neural Information Processing Systems
publist_id: '5782'
quality_controlled: '1'
status: public
title: Statistical topological data analysis-A kernel perspective
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 28
year: '2015'
...
---
_id: '1430'
abstract:
- lang: eng
text: Evolutionary algorithms (EAs) form a popular optimisation paradigm inspired
by natural evolution. In recent years the field of evolutionary computation has
developed a rigorous analytical theory to analyse their runtime on many illustrative
problems. Here we apply this theory to a simple model of natural evolution. In
the Strong Selection Weak Mutation (SSWM) evolutionary regime the time between
occurrence of new mutations is much longer than the time it takes for a new beneficial
mutation to take over the population. In this situation, the population only contains
copies of one genotype and evolution can be modelled as a (1+1)-type process where
the probability of accepting a new genotype (improvements or worsenings) depends
on the change in fitness. We present an initial runtime analysis of SSWM, quantifying
its performance for various parameters and investigating differences to the (1+1)
EA. We show that SSWM can have a moderate advantage over the (1+1) EA at crossing
fitness valleys and study an example where SSWM outperforms the (1+1) EA by taking
advantage of information on the fitness gradient.
author:
- first_name: Tiago
full_name: Paixao, Tiago
id: 2C5658E6-F248-11E8-B48F-1D18A9856A87
last_name: Paixao
orcid: 0000-0003-2361-3953
- first_name: Dirk
full_name: Sudholt, Dirk
last_name: Sudholt
- first_name: Jorge
full_name: Heredia, Jorge
last_name: Heredia
- first_name: Barbora
full_name: Trubenova, Barbora
id: 42302D54-F248-11E8-B48F-1D18A9856A87
last_name: Trubenova
orcid: 0000-0002-6873-2967
citation:
ama: 'Paixao T, Sudholt D, Heredia J, Trubenova B. First steps towards a runtime
comparison of natural and artificial evolution. In: Proceedings of the 2015
Annual Conference on Genetic and Evolutionary Computation. ACM; 2015:1455-1462.
doi:10.1145/2739480.2754758'
apa: 'Paixao, T., Sudholt, D., Heredia, J., & Trubenova, B. (2015). First steps
towards a runtime comparison of natural and artificial evolution. In Proceedings
of the 2015 Annual Conference on Genetic and Evolutionary Computation (pp.
1455–1462). Madrid, Spain: ACM. https://doi.org/10.1145/2739480.2754758'
chicago: Paixao, Tiago, Dirk Sudholt, Jorge Heredia, and Barbora Trubenova. “First
Steps towards a Runtime Comparison of Natural and Artificial Evolution.” In Proceedings
of the 2015 Annual Conference on Genetic and Evolutionary Computation, 1455–62.
ACM, 2015. https://doi.org/10.1145/2739480.2754758.
ieee: T. Paixao, D. Sudholt, J. Heredia, and B. Trubenova, “First steps towards
a runtime comparison of natural and artificial evolution,” in Proceedings of
the 2015 Annual Conference on Genetic and Evolutionary Computation, Madrid,
Spain, 2015, pp. 1455–1462.
ista: 'Paixao T, Sudholt D, Heredia J, Trubenova B. 2015. First steps towards a
runtime comparison of natural and artificial evolution. Proceedings of the 2015
Annual Conference on Genetic and Evolutionary Computation. GECCO: Genetic and
evolutionary computation conference, 1455–1462.'
mla: Paixao, Tiago, et al. “First Steps towards a Runtime Comparison of Natural
and Artificial Evolution.” Proceedings of the 2015 Annual Conference on Genetic
and Evolutionary Computation, ACM, 2015, pp. 1455–62, doi:10.1145/2739480.2754758.
short: T. Paixao, D. Sudholt, J. Heredia, B. Trubenova, in:, Proceedings of the
2015 Annual Conference on Genetic and Evolutionary Computation, ACM, 2015, pp.
1455–1462.
conference:
end_date: 2015-07-15
location: Madrid, Spain
name: 'GECCO: Genetic and evolutionary computation conference'
start_date: 2015-07-11
date_created: 2018-12-11T11:51:58Z
date_published: 2015-07-11T00:00:00Z
date_updated: 2021-01-12T06:50:41Z
day: '11'
department:
- _id: NiBa
- _id: CaGu
doi: 10.1145/2739480.2754758
ec_funded: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/1504.06260
month: '07'
oa: 1
oa_version: Preprint
page: 1455 - 1462
project:
- _id: 25B1EC9E-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '618091'
name: Speed of Adaptation in Population Genetics and Evolutionary Computation
publication: Proceedings of the 2015 Annual Conference on Genetic and Evolutionary
Computation
publication_status: published
publisher: ACM
publist_id: '5768'
quality_controlled: '1'
scopus_import: 1
status: public
title: First steps towards a runtime comparison of natural and artificial evolution
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2015'
...
---
_id: '1474'
abstract:
- lang: eng
text: Cryptographic access control offers selective access to encrypted data via
a combination of key management and functionality-rich cryptographic schemes,
such as attribute-based encryption. Using this approach, publicly available meta-data
may inadvertently leak information on the access policy that is enforced by cryptography,
which renders cryptographic access control unusable in settings where this information
is highly sensitive. We begin to address this problem by presenting rigorous definitions
for policy privacy in cryptographic access control. For concreteness we set our
results in the model of Role-Based Access Control (RBAC), where we identify and
formalize several different flavors of privacy, however, our framework should
serve as inspiration for other models of access control. Based on our insights
we propose a new system which significantly improves on the privacy properties
of state-of-the-art constructions. Our design is based on a novel type of privacy-preserving
attribute-based encryption, which we introduce and show how to instantiate. We
present our results in the context of a cryptographic RBAC system by Ferrara et
al. (CSF'13), which uses cryptography to control read access to files, while write
access is still delegated to trusted monitors. We give an extension of the construction
that permits cryptographic control over write access. Our construction assumes
that key management uses out-of-band channels between the policy enforcer and
the users but eliminates completely the need for monitoring read/write access
to the data.
article_processing_charge: No
author:
- first_name: Anna
full_name: Ferrara, Anna
last_name: Ferrara
- first_name: Georg
full_name: Fuchsbauer, Georg
id: 46B4C3EE-F248-11E8-B48F-1D18A9856A87
last_name: Fuchsbauer
- first_name: Bin
full_name: Liu, Bin
last_name: Liu
- first_name: Bogdan
full_name: Warinschi, Bogdan
last_name: Warinschi
citation:
ama: 'Ferrara A, Fuchsbauer G, Liu B, Warinschi B. Policy privacy in cryptographic
access control. In: IEEE; 2015:46-60. doi:10.1109/CSF.2015.11'
apa: 'Ferrara, A., Fuchsbauer, G., Liu, B., & Warinschi, B. (2015). Policy privacy
in cryptographic access control (pp. 46–60). Presented at the CSF: Computer Security
Foundations, Verona, Italy: IEEE. https://doi.org/10.1109/CSF.2015.11'
chicago: Ferrara, Anna, Georg Fuchsbauer, Bin Liu, and Bogdan Warinschi. “Policy
Privacy in Cryptographic Access Control,” 46–60. IEEE, 2015. https://doi.org/10.1109/CSF.2015.11.
ieee: 'A. Ferrara, G. Fuchsbauer, B. Liu, and B. Warinschi, “Policy privacy in cryptographic
access control,” presented at the CSF: Computer Security Foundations, Verona,
Italy, 2015, pp. 46–60.'
ista: 'Ferrara A, Fuchsbauer G, Liu B, Warinschi B. 2015. Policy privacy in cryptographic
access control. CSF: Computer Security Foundations, 46–60.'
mla: Ferrara, Anna, et al. Policy Privacy in Cryptographic Access Control.
IEEE, 2015, pp. 46–60, doi:10.1109/CSF.2015.11.
short: A. Ferrara, G. Fuchsbauer, B. Liu, B. Warinschi, in:, IEEE, 2015, pp. 46–60.
conference:
end_date: 2015-07-17
location: Verona, Italy
name: 'CSF: Computer Security Foundations'
start_date: 2015-07-13
date_created: 2018-12-11T11:52:14Z
date_published: 2015-09-04T00:00:00Z
date_updated: 2021-01-12T06:50:59Z
day: '04'
department:
- _id: KrPi
doi: 10.1109/CSF.2015.11
ec_funded: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://epubs.surrey.ac.uk/808055/
month: '09'
oa: 1
oa_version: Submitted Version
page: 46-60
project:
- _id: 258C570E-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '259668'
name: Provable Security for Physical Cryptography
publication_status: published
publisher: IEEE
publist_id: '5722'
quality_controlled: '1'
status: public
title: Policy privacy in cryptographic access control
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2015'
...
---
_id: '1473'
abstract:
- lang: eng
text: In this paper we survey geometric and arithmetic techniques to study the cohomology
of semiprojective hyperkähler manifolds including toric hyperkähler varieties,
Nakajima quiver varieties and moduli spaces of Higgs bundles on Riemann surfaces.
The resulting formulae for their Poincaré polynomials are combinatorial and representation
theoretical in nature. In particular we will look at their Betti numbers and will
establish some results and state some expectations on their asymptotic shape.
author:
- first_name: Tamas
full_name: Tamas Hausel
id: 4A0666D8-F248-11E8-B48F-1D18A9856A87
last_name: Hausel
- first_name: Fernando
full_name: Rodríguez Villegas, Fernando
last_name: Rodríguez Villegas
citation:
ama: Hausel T, Rodríguez Villegas F. Cohomology of large semiprojective hyperkähler
varieties. Asterisque. 2015;2015(370):113-156.
apa: Hausel, T., & Rodríguez Villegas, F. (2015). Cohomology of large semiprojective
hyperkähler varieties. Asterisque. Societe Mathematique de France.
chicago: Hausel, Tamás, and Fernando Rodríguez Villegas. “Cohomology of Large Semiprojective
Hyperkähler Varieties.” Asterisque. Societe Mathematique de France, 2015.
ieee: T. Hausel and F. Rodríguez Villegas, “Cohomology of large semiprojective hyperkähler
varieties,” Asterisque, vol. 2015, no. 370. Societe Mathematique de France,
pp. 113–156, 2015.
ista: Hausel T, Rodríguez Villegas F. 2015. Cohomology of large semiprojective hyperkähler
varieties. Asterisque. 2015(370), 113–156.
mla: Hausel, Tamás, and Fernando Rodríguez Villegas. “Cohomology of Large Semiprojective
Hyperkähler Varieties.” Asterisque, vol. 2015, no. 370, Societe Mathematique
de France, 2015, pp. 113–56.
short: T. Hausel, F. Rodríguez Villegas, Asterisque 2015 (2015) 113–156.
date_created: 2018-12-11T11:52:13Z
date_published: 2015-01-01T00:00:00Z
date_updated: 2021-01-12T06:50:59Z
day: '01'
extern: 1
intvolume: ' 2015'
issue: '370'
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/1309.4914
month: '01'
oa: 1
page: 113 - 156
publication: Asterisque
publication_status: published
publisher: Societe Mathematique de France
publist_id: '5723'
quality_controlled: 0
status: public
title: Cohomology of large semiprojective hyperkähler varieties
type: review
volume: 2015
year: '2015'
...
---
_id: '1483'
abstract:
- lang: eng
text: Topological data analysis offers a rich source of valuable information to
study vision problems. Yet, so far we lack a theoretically sound connection to
popular kernel-based learning techniques, such as kernel SVMs or kernel PCA. In
this work, we establish such a connection by designing a multi-scale kernel for
persistence diagrams, a stable summary representation of topological features
in data. We show that this kernel is positive definite and prove its stability
with respect to the 1-Wasserstein distance. Experiments on two benchmark datasets
for 3D shape classification/retrieval and texture recognition show considerable
performance gains of the proposed method compared to an alternative approach that
is based on the recently introduced persistence landscapes.
author:
- first_name: Jan
full_name: Reininghaus, Jan
id: 4505473A-F248-11E8-B48F-1D18A9856A87
last_name: Reininghaus
- first_name: Stefan
full_name: Huber, Stefan
id: 4700A070-F248-11E8-B48F-1D18A9856A87
last_name: Huber
orcid: 0000-0002-8871-5814
- first_name: Ulrich
full_name: Bauer, Ulrich
id: 2ADD483A-F248-11E8-B48F-1D18A9856A87
last_name: Bauer
orcid: 0000-0002-9683-0724
- first_name: Roland
full_name: Kwitt, Roland
last_name: Kwitt
citation:
ama: 'Reininghaus J, Huber S, Bauer U, Kwitt R. A stable multi-scale kernel for
topological machine learning. In: IEEE; 2015:4741-4748. doi:10.1109/CVPR.2015.7299106'
apa: 'Reininghaus, J., Huber, S., Bauer, U., & Kwitt, R. (2015). A stable multi-scale
kernel for topological machine learning (pp. 4741–4748). Presented at the CVPR:
Computer Vision and Pattern Recognition, Boston, MA, USA: IEEE. https://doi.org/10.1109/CVPR.2015.7299106'
chicago: Reininghaus, Jan, Stefan Huber, Ulrich Bauer, and Roland Kwitt. “A Stable
Multi-Scale Kernel for Topological Machine Learning,” 4741–48. IEEE, 2015. https://doi.org/10.1109/CVPR.2015.7299106.
ieee: 'J. Reininghaus, S. Huber, U. Bauer, and R. Kwitt, “A stable multi-scale kernel
for topological machine learning,” presented at the CVPR: Computer Vision and
Pattern Recognition, Boston, MA, USA, 2015, pp. 4741–4748.'
ista: 'Reininghaus J, Huber S, Bauer U, Kwitt R. 2015. A stable multi-scale kernel
for topological machine learning. CVPR: Computer Vision and Pattern Recognition,
4741–4748.'
mla: Reininghaus, Jan, et al. A Stable Multi-Scale Kernel for Topological Machine
Learning. IEEE, 2015, pp. 4741–48, doi:10.1109/CVPR.2015.7299106.
short: J. Reininghaus, S. Huber, U. Bauer, R. Kwitt, in:, IEEE, 2015, pp. 4741–4748.
conference:
end_date: 2015-06-12
location: Boston, MA, USA
name: 'CVPR: Computer Vision and Pattern Recognition'
start_date: 2015-06-07
date_created: 2018-12-11T11:52:17Z
date_published: 2015-10-14T00:00:00Z
date_updated: 2021-01-12T06:51:03Z
day: '14'
department:
- _id: HeEd
doi: 10.1109/CVPR.2015.7299106
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/1412.6821
month: '10'
oa: 1
oa_version: Preprint
page: 4741 - 4748
publication_identifier:
eisbn:
- '978-1-4673-6964-0 '
publication_status: published
publisher: IEEE
publist_id: '5709'
scopus_import: 1
status: public
title: A stable multi-scale kernel for topological machine learning
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2015'
...
---
_id: '1498'
abstract:
- lang: eng
text: Fault-tolerant distributed algorithms play an important role in many critical/high-availability
applications. These algorithms are notoriously difficult to implement correctly,
due to asynchronous communication and the occurrence of faults, such as the network
dropping messages or computers crashing. Nonetheless there is surprisingly little
language and verification support to build distributed systems based on fault-tolerant
algorithms. In this paper, we present some of the challenges that a designer has
to overcome to implement a fault-tolerant distributed system. Then we review different
models that have been proposed to reason about distributed algorithms and sketch
how such a model can form the basis for a domain-specific programming language.
Adopting a high-level programming model can simplify the programmer's life and
make the code amenable to automated verification, while still compiling to efficiently
executable code. We conclude by summarizing the current status of an ongoing language
design and implementation project that is based on this idea.
alternative_title:
- LIPIcs
author:
- first_name: Cezara
full_name: Dragoi, Cezara
id: 2B2B5ED0-F248-11E8-B48F-1D18A9856A87
last_name: Dragoi
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Damien
full_name: Zufferey, Damien
id: 4397AC76-F248-11E8-B48F-1D18A9856A87
last_name: Zufferey
orcid: 0000-0002-3197-8736
citation:
ama: Dragoi C, Henzinger TA, Zufferey D. The need for language support for fault-tolerant
distributed systems. 2015;32:90-102. doi:10.4230/LIPIcs.SNAPL.2015.90
apa: 'Dragoi, C., Henzinger, T. A., & Zufferey, D. (2015). The need for language
support for fault-tolerant distributed systems. Presented at the SNAPL: Summit
oN Advances in Programming Languages, Asilomar, CA, United States: Schloss Dagstuhl
- Leibniz-Zentrum für Informatik. https://doi.org/10.4230/LIPIcs.SNAPL.2015.90'
chicago: Dragoi, Cezara, Thomas A Henzinger, and Damien Zufferey. “The Need for
Language Support for Fault-Tolerant Distributed Systems.” Leibniz International
Proceedings in Informatics. Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
2015. https://doi.org/10.4230/LIPIcs.SNAPL.2015.90.
ieee: C. Dragoi, T. A. Henzinger, and D. Zufferey, “The need for language support
for fault-tolerant distributed systems,” vol. 32. Schloss Dagstuhl - Leibniz-Zentrum
für Informatik, pp. 90–102, 2015.
ista: Dragoi C, Henzinger TA, Zufferey D. 2015. The need for language support for
fault-tolerant distributed systems. 32, 90–102.
mla: Dragoi, Cezara, et al. The Need for Language Support for Fault-Tolerant
Distributed Systems. Vol. 32, Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
2015, pp. 90–102, doi:10.4230/LIPIcs.SNAPL.2015.90.
short: C. Dragoi, T.A. Henzinger, D. Zufferey, 32 (2015) 90–102.
conference:
end_date: 2015-05-06
location: Asilomar, CA, United States
name: 'SNAPL: Summit oN Advances in Programming Languages'
start_date: 2015-05-03
date_created: 2018-12-11T11:52:22Z
date_published: 2015-01-01T00:00:00Z
date_updated: 2020-08-11T10:09:14Z
day: '01'
ddc:
- '005'
department:
- _id: ToHe
doi: 10.4230/LIPIcs.SNAPL.2015.90
ec_funded: 1
file:
- access_level: open_access
checksum: cf5e94baa89a2dc4c5de01abc676eda8
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:14:02Z
date_updated: 2020-07-14T12:44:58Z
file_id: '5050'
file_name: IST-2016-499-v1+1_9.pdf
file_size: 489362
relation: main_file
file_date_updated: 2020-07-14T12:44:58Z
has_accepted_license: '1'
intvolume: ' 32'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
page: 90 - 102
project:
- _id: 25EE3708-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '267989'
name: Quantitative Reactive Modeling
- _id: 25F5A88A-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S11402-N23
name: Moderne Concurrency Paradigms
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z211
name: The Wittgenstein Prize
publication_identifier:
isbn:
- '978-3-939897-80-4 '
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
publist_id: '5681'
pubrep_id: '499'
quality_controlled: '1'
scopus_import: 1
series_title: Leibniz International Proceedings in Informatics
status: public
title: The need for language support for fault-tolerant distributed systems
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 32
year: '2015'
...
---
_id: '1497'
abstract:
- lang: eng
text: Detecting allelic biases from high-throughput sequencing data requires an
approach that maximises sensitivity while minimizing false positives. Here, we
present Allelome.PRO, an automated user-friendly bioinformatics pipeline, which
uses high-throughput sequencing data from reciprocal crosses of two genetically
distinct mouse strains to detect allele-specific expression and chromatin modifications.
Allelome.PRO extends approaches used in previous studies that exclusively analyzed
imprinted expression to give a complete picture of the ‘allelome’ by automatically
categorising the allelic expression of all genes in a given cell type into imprinted,
strain-biased, biallelic or non-informative. Allelome.PRO offers increased sensitivity
to analyze lowly expressed transcripts, together with a robust false discovery
rate empirically calculated from variation in the sequencing data. We used RNA-seq
data from mouse embryonic fibroblasts from F1 reciprocal crosses to determine
a biologically relevant allelic ratio cutoff, and define for the first time an
entire allelome. Furthermore, we show that Allelome.PRO detects differential enrichment
of H3K4me3 over promoters from ChIP-seq data validating the RNA-seq results. This
approach can be easily extended to analyze histone marks of active enhancers,
or transcription factor binding sites and therefore provides a powerful tool to
identify candidate cis regulatory elements genome wide.
acknowledgement: "Austrian Science Fund [FWF P25185-B22, FWF F4302- B09, FWFW1207-B09].
Funding for open access charge: Austrian Science Fund.\r\nWe thank Florian Breitwieser
for advice during the early stages of this project. High-throughput sequencing was
conducted by the Biomedical Sequencing Facility (BSF) at CeMM in Vienna."
article_number: e146
author:
- first_name: Daniel
full_name: Andergassen, Daniel
last_name: Andergassen
- first_name: Christoph
full_name: Dotter, Christoph
id: 4C66542E-F248-11E8-B48F-1D18A9856A87
last_name: Dotter
- first_name: Tomasz
full_name: Kulinski, Tomasz
last_name: Kulinski
- first_name: Philipp
full_name: Guenzl, Philipp
last_name: Guenzl
- first_name: Philipp
full_name: Bammer, Philipp
last_name: Bammer
- first_name: Denise
full_name: Barlow, Denise
last_name: Barlow
- first_name: Florian
full_name: Pauler, Florian
last_name: Pauler
- first_name: Quanah
full_name: Hudson, Quanah
last_name: Hudson
citation:
ama: Andergassen D, Dotter C, Kulinski T, et al. Allelome.PRO, a pipeline to define
allele-specific genomic features from high-throughput sequencing data. Nucleic
Acids Research. 2015;43(21). doi:10.1093/nar/gkv727
apa: Andergassen, D., Dotter, C., Kulinski, T., Guenzl, P., Bammer, P., Barlow,
D., … Hudson, Q. (2015). Allelome.PRO, a pipeline to define allele-specific genomic
features from high-throughput sequencing data. Nucleic Acids Research.
Oxford University Press. https://doi.org/10.1093/nar/gkv727
chicago: Andergassen, Daniel, Christoph Dotter, Tomasz Kulinski, Philipp Guenzl,
Philipp Bammer, Denise Barlow, Florian Pauler, and Quanah Hudson. “Allelome.PRO,
a Pipeline to Define Allele-Specific Genomic Features from High-Throughput Sequencing
Data.” Nucleic Acids Research. Oxford University Press, 2015. https://doi.org/10.1093/nar/gkv727.
ieee: D. Andergassen et al., “Allelome.PRO, a pipeline to define allele-specific
genomic features from high-throughput sequencing data,” Nucleic Acids Research,
vol. 43, no. 21. Oxford University Press, 2015.
ista: Andergassen D, Dotter C, Kulinski T, Guenzl P, Bammer P, Barlow D, Pauler
F, Hudson Q. 2015. Allelome.PRO, a pipeline to define allele-specific genomic
features from high-throughput sequencing data. Nucleic Acids Research. 43(21),
e146.
mla: Andergassen, Daniel, et al. “Allelome.PRO, a Pipeline to Define Allele-Specific
Genomic Features from High-Throughput Sequencing Data.” Nucleic Acids Research,
vol. 43, no. 21, e146, Oxford University Press, 2015, doi:10.1093/nar/gkv727.
short: D. Andergassen, C. Dotter, T. Kulinski, P. Guenzl, P. Bammer, D. Barlow,
F. Pauler, Q. Hudson, Nucleic Acids Research 43 (2015).
date_created: 2018-12-11T11:52:22Z
date_published: 2015-07-21T00:00:00Z
date_updated: 2021-01-12T06:51:09Z
day: '21'
ddc:
- '570'
department:
- _id: GaNo
doi: 10.1093/nar/gkv727
file:
- access_level: open_access
checksum: 385b83854fd0eb2e4f386867da2823e2
content_type: application/pdf
creator: dernst
date_created: 2018-12-20T14:18:57Z
date_updated: 2020-07-14T12:44:58Z
file_id: '5768'
file_name: 2015_NucleicAcidsRes_Andergassen.pdf
file_size: 6863297
relation: main_file
file_date_updated: 2020-07-14T12:44:58Z
has_accepted_license: '1'
intvolume: ' 43'
issue: '21'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
publication: Nucleic Acids Research
publication_status: published
publisher: Oxford University Press
publist_id: '5682'
quality_controlled: '1'
scopus_import: 1
status: public
title: Allelome.PRO, a pipeline to define allele-specific genomic features from high-throughput
sequencing data
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 43
year: '2015'
...
---
_id: '1499'
abstract:
- lang: eng
text: "We consider weighted automata with both positive and negative integer weights
on edges and\r\nstudy the problem of synchronization using adaptive strategies
that may only observe whether\r\nthe current weight-level is negative or nonnegative.
We show that the synchronization problem is decidable in polynomial time for deterministic
weighted automata."
acknowledgement: "The research leading to these results has received funding from
the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement
601148 (CASSTING), EU FP7 FET project SENSATION, Sino-Danish Basic Research Center
IDAE4CPS, the European Research Council (ERC) under grant agreement 267989 (QUAREM),
the Austrian Science Fund (FWF) project S11402-N23 (RiSE) and Z211-N23 (Wittgenstein
Award), the Czech Science Foundation under grant agreement P202/12/G061, and People
Programme (Marie Curie Actions) of the European Union’s Seventh Framework\r\nProgramme
(FP7/2007-2013) REA Grant No 291734."
alternative_title:
- LIPIcs
author:
- first_name: Jan
full_name: Kretinsky, Jan
id: 44CEF464-F248-11E8-B48F-1D18A9856A87
last_name: Kretinsky
orcid: 0000-0002-8122-2881
- first_name: Kim
full_name: Larsen, Kim
last_name: Larsen
- first_name: Simon
full_name: Laursen, Simon
last_name: Laursen
- first_name: Jiří
full_name: Srba, Jiří
last_name: Srba
citation:
ama: 'Kretinsky J, Larsen K, Laursen S, Srba J. Polynomial time decidability of
weighted synchronization under partial observability. In: Vol 42. Schloss Dagstuhl
- Leibniz-Zentrum für Informatik; 2015:142-154. doi:10.4230/LIPIcs.CONCUR.2015.142'
apa: 'Kretinsky, J., Larsen, K., Laursen, S., & Srba, J. (2015). Polynomial
time decidability of weighted synchronization under partial observability (Vol.
42, pp. 142–154). Presented at the CONCUR: Concurrency Theory, Madrid, Spain:
Schloss Dagstuhl - Leibniz-Zentrum für Informatik. https://doi.org/10.4230/LIPIcs.CONCUR.2015.142'
chicago: Kretinsky, Jan, Kim Larsen, Simon Laursen, and Jiří Srba. “Polynomial Time
Decidability of Weighted Synchronization under Partial Observability,” 42:142–54.
Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2015. https://doi.org/10.4230/LIPIcs.CONCUR.2015.142.
ieee: 'J. Kretinsky, K. Larsen, S. Laursen, and J. Srba, “Polynomial time decidability
of weighted synchronization under partial observability,” presented at the CONCUR:
Concurrency Theory, Madrid, Spain, 2015, vol. 42, pp. 142–154.'
ista: 'Kretinsky J, Larsen K, Laursen S, Srba J. 2015. Polynomial time decidability
of weighted synchronization under partial observability. CONCUR: Concurrency Theory,
LIPIcs, vol. 42, 142–154.'
mla: Kretinsky, Jan, et al. Polynomial Time Decidability of Weighted Synchronization
under Partial Observability. Vol. 42, Schloss Dagstuhl - Leibniz-Zentrum für
Informatik, 2015, pp. 142–54, doi:10.4230/LIPIcs.CONCUR.2015.142.
short: J. Kretinsky, K. Larsen, S. Laursen, J. Srba, in:, Schloss Dagstuhl - Leibniz-Zentrum
für Informatik, 2015, pp. 142–154.
conference:
end_date: 2015-09-04
location: Madrid, Spain
name: 'CONCUR: Concurrency Theory'
start_date: 2015-09-01
date_created: 2018-12-11T11:52:22Z
date_published: 2015-01-01T00:00:00Z
date_updated: 2021-01-12T06:51:10Z
day: '01'
ddc:
- '000'
- '003'
department:
- _id: ToHe
- _id: KrCh
doi: 10.4230/LIPIcs.CONCUR.2015.142
ec_funded: 1
file:
- access_level: open_access
checksum: 49eb5021caafaabe5356c65b9c5f8c9c
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:08:12Z
date_updated: 2020-07-14T12:44:58Z
file_id: '4672'
file_name: IST-2016-498-v1+1_32.pdf
file_size: 623563
relation: main_file
file_date_updated: 2020-07-14T12:44:58Z
has_accepted_license: '1'
intvolume: ' 42'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
page: 142 - 154
project:
- _id: 25EE3708-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '267989'
name: Quantitative Reactive Modeling
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S 11407_N23
name: Rigorous Systems Engineering
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z211
name: The Wittgenstein Prize
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
publist_id: '5680'
pubrep_id: '498'
quality_controlled: '1'
scopus_import: 1
status: public
title: Polynomial time decidability of weighted synchronization under partial observability
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 42
year: '2015'
...
---
_id: '1495'
abstract:
- lang: eng
text: 'Motivated by biological questions, we study configurations of equal-sized
disks in the Euclidean plane that neither pack nor cover. Measuring the quality
by the probability that a random point lies in exactly one disk, we show that
the regular hexagonal grid gives the maximum among lattice configurations. '
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Mabel
full_name: Iglesias Ham, Mabel
id: 41B58C0C-F248-11E8-B48F-1D18A9856A87
last_name: Iglesias Ham
- first_name: Vitaliy
full_name: Kurlin, Vitaliy
last_name: Kurlin
citation:
ama: 'Edelsbrunner H, Iglesias Ham M, Kurlin V. Relaxed disk packing. In: Proceedings
of the 27th Canadian Conference on Computational Geometry. Vol 2015-August.
Queen’s University; 2015:128-135.'
apa: 'Edelsbrunner, H., Iglesias Ham, M., & Kurlin, V. (2015). Relaxed disk
packing. In Proceedings of the 27th Canadian Conference on Computational Geometry
(Vol. 2015–August, pp. 128–135). Ontario, Canada: Queen’s University.'
chicago: Edelsbrunner, Herbert, Mabel Iglesias Ham, and Vitaliy Kurlin. “Relaxed
Disk Packing.” In Proceedings of the 27th Canadian Conference on Computational
Geometry, 2015–August:128–35. Queen’s University, 2015.
ieee: H. Edelsbrunner, M. Iglesias Ham, and V. Kurlin, “Relaxed disk packing,” in
Proceedings of the 27th Canadian Conference on Computational Geometry,
Ontario, Canada, 2015, vol. 2015–August, pp. 128–135.
ista: 'Edelsbrunner H, Iglesias Ham M, Kurlin V. 2015. Relaxed disk packing. Proceedings
of the 27th Canadian Conference on Computational Geometry. CCCG: Canadian Conference
on Computational Geometry vol. 2015–August, 128–135.'
mla: Edelsbrunner, Herbert, et al. “Relaxed Disk Packing.” Proceedings of the
27th Canadian Conference on Computational Geometry, vol. 2015–August, Queen’s
University, 2015, pp. 128–35.
short: H. Edelsbrunner, M. Iglesias Ham, V. Kurlin, in:, Proceedings of the 27th
Canadian Conference on Computational Geometry, Queen’s University, 2015, pp. 128–135.
conference:
end_date: 2015-08-12
location: Ontario, Canada
name: 'CCCG: Canadian Conference on Computational Geometry'
start_date: 2015-08-10
date_created: 2018-12-11T11:52:21Z
date_published: 2015-08-01T00:00:00Z
date_updated: 2021-01-12T06:51:09Z
day: '01'
department:
- _id: HeEd
ec_funded: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1505.03402
month: '08'
oa: 1
oa_version: Submitted Version
page: 128-135
project:
- _id: 255D761E-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '318493'
name: Topological Complex Systems
publication: Proceedings of the 27th Canadian Conference on Computational Geometry
publication_status: published
publisher: Queen's University
publist_id: '5684'
quality_controlled: '1'
scopus_import: 1
status: public
title: Relaxed disk packing
type: conference
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 2015-August
year: '2015'
...
---
_id: '1504'
abstract:
- lang: eng
text: Let Q = (Q1, . . . , Qn) be a random vector drawn from the uniform distribution
on the set of all n! permutations of {1, 2, . . . , n}. Let Z = (Z1, . . . , Zn),
where Zj is the mean zero variance one random variable obtained by centralizing
and normalizing Qj , j = 1, . . . , n. Assume that Xi , i = 1, . . . ,p are i.i.d.
copies of 1/√ p Z and X = Xp,n is the p × n random matrix with Xi as its ith row.
Then Sn = XX is called the p × n Spearman's rank correlation matrix which can
be regarded as a high dimensional extension of the classical nonparametric statistic
Spearman's rank correlation coefficient between two independent random variables.
In this paper, we establish a CLT for the linear spectral statistics of this nonparametric
random matrix model in the scenario of high dimension, namely, p = p(n) and p/n→c
∈ (0,∞) as n→∞.We propose a novel evaluation scheme to estimate the core quantity
in Anderson and Zeitouni's cumulant method in [Ann. Statist. 36 (2008) 2553-2576]
to bypass the so-called joint cumulant summability. In addition, we raise a two-step
comparison approach to obtain the explicit formulae for the mean and covariance
functions in the CLT. Relying on this CLT, we then construct a distribution-free
statistic to test complete independence for components of random vectors. Owing
to the nonparametric property, we can use this test on generally distributed random
variables including the heavy-tailed ones.
author:
- first_name: Zhigang
full_name: Bao, Zhigang
id: 442E6A6C-F248-11E8-B48F-1D18A9856A87
last_name: Bao
orcid: 0000-0003-3036-1475
- first_name: Liang
full_name: Lin, Liang
last_name: Lin
- first_name: Guangming
full_name: Pan, Guangming
last_name: Pan
- first_name: Wang
full_name: Zhou, Wang
last_name: Zhou
citation:
ama: Bao Z, Lin L, Pan G, Zhou W. Spectral statistics of large dimensional spearman
s rank correlation matrix and its application. Annals of Statistics. 2015;43(6):2588-2623.
doi:10.1214/15-AOS1353
apa: Bao, Z., Lin, L., Pan, G., & Zhou, W. (2015). Spectral statistics of large
dimensional spearman s rank correlation matrix and its application. Annals
of Statistics. Institute of Mathematical Statistics. https://doi.org/10.1214/15-AOS1353
chicago: Bao, Zhigang, Liang Lin, Guangming Pan, and Wang Zhou. “Spectral Statistics
of Large Dimensional Spearman s Rank Correlation Matrix and Its Application.”
Annals of Statistics. Institute of Mathematical Statistics, 2015. https://doi.org/10.1214/15-AOS1353.
ieee: Z. Bao, L. Lin, G. Pan, and W. Zhou, “Spectral statistics of large dimensional
spearman s rank correlation matrix and its application,” Annals of Statistics,
vol. 43, no. 6. Institute of Mathematical Statistics, pp. 2588–2623, 2015.
ista: Bao Z, Lin L, Pan G, Zhou W. 2015. Spectral statistics of large dimensional
spearman s rank correlation matrix and its application. Annals of Statistics.
43(6), 2588–2623.
mla: Bao, Zhigang, et al. “Spectral Statistics of Large Dimensional Spearman s Rank
Correlation Matrix and Its Application.” Annals of Statistics, vol. 43,
no. 6, Institute of Mathematical Statistics, 2015, pp. 2588–623, doi:10.1214/15-AOS1353.
short: Z. Bao, L. Lin, G. Pan, W. Zhou, Annals of Statistics 43 (2015) 2588–2623.
date_created: 2018-12-11T11:52:24Z
date_published: 2015-12-01T00:00:00Z
date_updated: 2021-01-12T06:51:14Z
day: '01'
doi: 10.1214/15-AOS1353
extern: '1'
intvolume: ' 43'
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1312.5119
month: '12'
oa: 1
oa_version: Published Version
page: 2588 - 2623
publication: Annals of Statistics
publication_status: published
publisher: Institute of Mathematical Statistics
publist_id: '5674'
quality_controlled: '1'
status: public
title: Spectral statistics of large dimensional spearman s rank correlation matrix
and its application
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 43
year: '2015'
...
---
_id: '1500'
abstract:
- lang: eng
text: In this poster, we present methods for randomly generating hybrid automata
with affine differential equations, invariants, guards, and assignments. Selecting
an arbitrary affine function from the set of all affine functions results in a
low likelihood of generating hybrid automata with diverse and interesting behaviors,
as there are an uncountable number of elements in the set of all affine functions.
Instead, we partition the set of all affine functions into potentially interesting
classes and randomly select elements from these classes. For example, we partition
the set of all affine differential equations by using restrictions on eigenvalues
such as those that yield stable, unstable, etc. equilibrium points. We partition
the components describing discrete behavior (guards, assignments, and invariants)
to allow either time-dependent or state-dependent switching, and in particular
provide the ability to generate subclasses of piecewise-affine hybrid automata.
Our preliminary experimental results with a prototype tool called HyRG (Hybrid
Random Generator) illustrate the feasibility of this generation method to automatically
create standard hybrid automaton examples like the bouncing ball and thermostat.
alternative_title:
- '18th ACM International Conference on Hybrid Systems: Computation and Control, HSCC
2015'
author:
- first_name: Luan
full_name: Nguyen, Luan V
last_name: Nguyen
- first_name: Christian
full_name: Christian Schilling
id: 3A2F4DCE-F248-11E8-B48F-1D18A9856A87
last_name: Schilling
orcid: 0000-0003-3658-1065
- first_name: Sergiy
full_name: Sergiy Bogomolov
id: 369D9A44-F248-11E8-B48F-1D18A9856A87
last_name: Bogomolov
orcid: 0000-0002-0686-0365
- first_name: Taylor
full_name: Johnson, Taylor T
last_name: Johnson
citation:
ama: 'Nguyen L, Schilling C, Bogomolov S, Johnson T. Poster: HyRG: A Random Generation
Tool for Affine Hybrid Automata. Springer; 2015:289-290. doi:10.1145/2728606.2728650'
apa: 'Nguyen, L., Schilling, C., Bogomolov, S., & Johnson, T. (2015). Poster:
HyRG: A random generation tool for affine hybrid automata. HSCC: Hybrid
Systems - Computation and Control (pp. 289–290). Springer. https://doi.org/10.1145/2728606.2728650'
chicago: 'Nguyen, Luan, Christian Schilling, Sergiy Bogomolov, and Taylor Johnson.
Poster: HyRG: A Random Generation Tool for Affine Hybrid Automata. HSCC:
Hybrid Systems - Computation and Control. Springer, 2015. https://doi.org/10.1145/2728606.2728650.'
ieee: 'L. Nguyen, C. Schilling, S. Bogomolov, and T. Johnson, Poster: HyRG: A
random generation tool for affine hybrid automata. Springer, 2015, pp. 289–290.'
ista: 'Nguyen L, Schilling C, Bogomolov S, Johnson T. 2015. Poster: HyRG: A random
generation tool for affine hybrid automata, Springer,p.'
mla: 'Nguyen, Luan, et al. “Poster: HyRG: A Random Generation Tool for Affine Hybrid
Automata.” HSCC: Hybrid Systems - Computation and Control, Springer, 2015,
pp. 289–90, doi:10.1145/2728606.2728650.'
short: 'L. Nguyen, C. Schilling, S. Bogomolov, T. Johnson, Poster: HyRG: A Random
Generation Tool for Affine Hybrid Automata, Springer, 2015.'
date_created: 2018-12-11T11:52:23Z
date_published: 2015-04-14T00:00:00Z
date_updated: 2019-04-26T07:22:03Z
day: '14'
doi: 10.1145/2728606.2728650
extern: 1
month: '04'
page: 289 - 290
publication: 'HSCC: Hybrid Systems - Computation and Control'
publication_status: published
publisher: Springer
publist_id: '5678'
quality_controlled: 0
status: public
title: 'Poster: HyRG: A random generation tool for affine hybrid automata'
type: conference_poster
year: '2015'
...
---
_id: '1503'
abstract:
- lang: eng
text: A Herman-Avila-Bochi type formula is obtained for the average sum of the top
d Lyapunov exponents over a one-parameter family of double-struck G-cocycles,
where double-struck G is the group that leaves a certain, non-degenerate Hermitian
form of signature (c, d) invariant. The generic example of such a group is the
pseudo-unitary group U(c, d) or, in the case c = d, the Hermitian-symplectic group
HSp(2d) which naturally appears for cocycles related to Schrödinger operators.
In the case d = 1, the formula for HSp(2d) cocycles reduces to the Herman-Avila-Bochi
formula for SL(2, ℝ) cocycles.
author:
- first_name: Christian
full_name: Sadel, Christian
id: 4760E9F8-F248-11E8-B48F-1D18A9856A87
last_name: Sadel
orcid: 0000-0001-8255-3968
citation:
ama: Sadel C. A Herman-Avila-Bochi formula for higher-dimensional pseudo-unitary
and Hermitian-symplectic-cocycles. Ergodic Theory and Dynamical Systems.
2015;35(5):1582-1591. doi:10.1017/etds.2013.103
apa: Sadel, C. (2015). A Herman-Avila-Bochi formula for higher-dimensional pseudo-unitary
and Hermitian-symplectic-cocycles. Ergodic Theory and Dynamical Systems.
Cambridge University Press. https://doi.org/10.1017/etds.2013.103
chicago: Sadel, Christian. “A Herman-Avila-Bochi Formula for Higher-Dimensional
Pseudo-Unitary and Hermitian-Symplectic-Cocycles.” Ergodic Theory and Dynamical
Systems. Cambridge University Press, 2015. https://doi.org/10.1017/etds.2013.103.
ieee: C. Sadel, “A Herman-Avila-Bochi formula for higher-dimensional pseudo-unitary
and Hermitian-symplectic-cocycles,” Ergodic Theory and Dynamical Systems,
vol. 35, no. 5. Cambridge University Press, pp. 1582–1591, 2015.
ista: Sadel C. 2015. A Herman-Avila-Bochi formula for higher-dimensional pseudo-unitary
and Hermitian-symplectic-cocycles. Ergodic Theory and Dynamical Systems. 35(5),
1582–1591.
mla: Sadel, Christian. “A Herman-Avila-Bochi Formula for Higher-Dimensional Pseudo-Unitary
and Hermitian-Symplectic-Cocycles.” Ergodic Theory and Dynamical Systems,
vol. 35, no. 5, Cambridge University Press, 2015, pp. 1582–91, doi:10.1017/etds.2013.103.
short: C. Sadel, Ergodic Theory and Dynamical Systems 35 (2015) 1582–1591.
date_created: 2018-12-11T11:52:24Z
date_published: 2015-03-14T00:00:00Z
date_updated: 2021-01-12T06:51:13Z
day: '14'
doi: 10.1017/etds.2013.103
extern: '1'
intvolume: ' 35'
issue: '5'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1307.8414
month: '03'
oa: 1
oa_version: Preprint
page: 1582 - 1591
publication: Ergodic Theory and Dynamical Systems
publication_status: published
publisher: Cambridge University Press
publist_id: '5675'
quality_controlled: '1'
status: public
title: A Herman-Avila-Bochi formula for higher-dimensional pseudo-unitary and Hermitian-symplectic-cocycles
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 35
year: '2015'
...
---
_id: '1510'
abstract:
- lang: eng
text: 'The concept of well group in a special but important case captures homological
properties of the zero set of a continuous map f from K to R^n on a compact space
K that are invariant with respect to perturbations of f. The perturbations are
arbitrary continuous maps within L_infty distance r from f for a given r >
0. The main drawback of the approach is that the computability of well groups
was shown only when dim K = n or n = 1. Our contribution to the theory of well
groups is twofold: on the one hand we improve on the computability issue, but
on the other hand we present a range of examples where the well groups are incomplete
invariants, that is, fail to capture certain important robust properties of the
zero set. For the first part, we identify a computable subgroup of the well group
that is obtained by cap product with the pullback of the orientation of R^n by
f. In other words, well groups can be algorithmically approximated from below.
When f is smooth and dim K < 2n-2, our approximation of the (dim K-n)th well
group is exact. For the second part, we find examples of maps f, f'' from K to
R^n with all well groups isomorphic but whose perturbations have different zero
sets. We discuss on a possible replacement of the well groups of vector valued
maps by an invariant of a better descriptive power and computability status. '
alternative_title:
- LIPIcs
author:
- first_name: Peter
full_name: Franek, Peter
id: 473294AE-F248-11E8-B48F-1D18A9856A87
last_name: Franek
- first_name: Marek
full_name: Krcál, Marek
id: 33E21118-F248-11E8-B48F-1D18A9856A87
last_name: Krcál
citation:
ama: 'Franek P, Krcál M. On computability and triviality of well groups. In: Vol
34. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2015:842-856. doi:10.4230/LIPIcs.SOCG.2015.842'
apa: 'Franek, P., & Krcál, M. (2015). On computability and triviality of well
groups (Vol. 34, pp. 842–856). Presented at the SoCG: Symposium on Computational
Geometry, Eindhoven, Netherlands: Schloss Dagstuhl - Leibniz-Zentrum für Informatik.
https://doi.org/10.4230/LIPIcs.SOCG.2015.842'
chicago: Franek, Peter, and Marek Krcál. “On Computability and Triviality of Well
Groups,” 34:842–56. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2015. https://doi.org/10.4230/LIPIcs.SOCG.2015.842.
ieee: 'P. Franek and M. Krcál, “On computability and triviality of well groups,”
presented at the SoCG: Symposium on Computational Geometry, Eindhoven, Netherlands,
2015, vol. 34, pp. 842–856.'
ista: 'Franek P, Krcál M. 2015. On computability and triviality of well groups.
SoCG: Symposium on Computational Geometry, LIPIcs, vol. 34, 842–856.'
mla: Franek, Peter, and Marek Krcál. On Computability and Triviality of Well
Groups. Vol. 34, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2015,
pp. 842–56, doi:10.4230/LIPIcs.SOCG.2015.842.
short: P. Franek, M. Krcál, in:, Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
2015, pp. 842–856.
conference:
end_date: 2015-06-25
location: Eindhoven, Netherlands
name: 'SoCG: Symposium on Computational Geometry'
start_date: 2015-06-22
date_created: 2018-12-11T11:52:26Z
date_published: 2015-06-11T00:00:00Z
date_updated: 2023-02-21T17:02:57Z
day: '11'
ddc:
- '510'
department:
- _id: UlWa
- _id: HeEd
doi: 10.4230/LIPIcs.SOCG.2015.842
ec_funded: 1
file:
- access_level: open_access
checksum: 49eb5021caafaabe5356c65b9c5f8c9c
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:13:19Z
date_updated: 2020-07-14T12:44:59Z
file_id: '5001'
file_name: IST-2016-503-v1+1_32.pdf
file_size: 623563
relation: main_file
file_date_updated: 2020-07-14T12:44:59Z
has_accepted_license: '1'
intvolume: ' 34'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: 842 - 856
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
publist_id: '5667'
pubrep_id: '503'
quality_controlled: '1'
related_material:
record:
- id: '1408'
relation: later_version
status: public
scopus_import: 1
status: public
title: On computability and triviality of well groups
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 34
year: '2015'
...
---
_id: '1505'
abstract:
- lang: eng
text: This paper is aimed at deriving the universality of the largest eigenvalue
of a class of high-dimensional real or complex sample covariance matrices of the
form W N =Σ 1/2XX∗Σ 1/2 . Here, X = (xij )M,N is an M× N random matrix with independent
entries xij , 1 ≤ i M,≤ 1 ≤ j ≤ N such that Exij = 0, E|xij |2 = 1/N . On dimensionality,
we assume that M = M(N) and N/M → d ε (0, ∞) as N ∞→. For a class of general deterministic
positive-definite M × M matrices Σ , under some additional assumptions on the
distribution of xij 's, we show that the limiting behavior of the largest eigenvalue
of W N is universal, via pursuing a Green function comparison strategy raised
in [Probab. Theory Related Fields 154 (2012) 341-407, Adv. Math. 229 (2012) 1435-1515]
by Erd″os, Yau and Yin for Wigner matrices and extended by Pillai and Yin [Ann.
Appl. Probab. 24 (2014) 935-1001] to sample covariance matrices in the null case
(&Epsi = I ). Consequently, in the standard complex case (Ex2 ij = 0), combing
this universality property and the results known for Gaussian matrices obtained
by El Karoui in [Ann. Probab. 35 (2007) 663-714] (nonsingular case) and Onatski
in [Ann. Appl. Probab. 18 (2008) 470-490] (singular case), we show that after
an appropriate normalization the largest eigenvalue of W N converges weakly to
the type 2 Tracy-Widom distribution TW2 . Moreover, in the real case, we show
that whenΣ is spiked with a fixed number of subcritical spikes, the type 1 Tracy-Widom
limit TW1 holds for the normalized largest eigenvalue of W N , which extends a
result of Féral and Péché in [J. Math. Phys. 50 (2009) 073302] to the scenario
of nondiagonal Σ and more generally distributed X . In summary, we establish the
Tracy-Widom type universality for the largest eigenvalue of generally distributed
sample covariance matrices under quite light assumptions on &Sigma . Applications
of these limiting results to statistical signal detection and structure recognition
of separable covariance matrices are also discussed.
acknowledgement: "B.Z. was supported in part by NSFC Grant 11071213, ZJNSF
\ Grant R6090034 and SRFDP Grant 20100101110001. P.G. was supported in part
by the Ministry of Education, Singapore, under Grant ARC 14/11. Z.W. was supported
\ in part by the Ministry of Education, Singapore, under Grant ARC 14/11,
\ and by a Grant R-155-000-131-112 at the National University of Singapore\r\n"
author:
- first_name: Zhigang
full_name: Bao, Zhigang
id: 442E6A6C-F248-11E8-B48F-1D18A9856A87
last_name: Bao
orcid: 0000-0003-3036-1475
- first_name: Guangming
full_name: Pan, Guangming
last_name: Pan
- first_name: Wang
full_name: Zhou, Wang
last_name: Zhou
citation:
ama: Bao Z, Pan G, Zhou W. Universality for the largest eigenvalue of sample covariance
matrices with general population. Annals of Statistics. 2015;43(1):382-421.
doi:10.1214/14-AOS1281
apa: Bao, Z., Pan, G., & Zhou, W. (2015). Universality for the largest eigenvalue
of sample covariance matrices with general population. Annals of Statistics.
Institute of Mathematical Statistics. https://doi.org/10.1214/14-AOS1281
chicago: Bao, Zhigang, Guangming Pan, and Wang Zhou. “Universality for the Largest
Eigenvalue of Sample Covariance Matrices with General Population.” Annals of
Statistics. Institute of Mathematical Statistics, 2015. https://doi.org/10.1214/14-AOS1281.
ieee: Z. Bao, G. Pan, and W. Zhou, “Universality for the largest eigenvalue of sample
covariance matrices with general population,” Annals of Statistics, vol.
43, no. 1. Institute of Mathematical Statistics, pp. 382–421, 2015.
ista: Bao Z, Pan G, Zhou W. 2015. Universality for the largest eigenvalue of sample
covariance matrices with general population. Annals of Statistics. 43(1), 382–421.
mla: Bao, Zhigang, et al. “Universality for the Largest Eigenvalue of Sample Covariance
Matrices with General Population.” Annals of Statistics, vol. 43, no. 1,
Institute of Mathematical Statistics, 2015, pp. 382–421, doi:10.1214/14-AOS1281.
short: Z. Bao, G. Pan, W. Zhou, Annals of Statistics 43 (2015) 382–421.
date_created: 2018-12-11T11:52:25Z
date_published: 2015-02-01T00:00:00Z
date_updated: 2021-01-12T06:51:14Z
day: '01'
department:
- _id: LaEr
doi: 10.1214/14-AOS1281
intvolume: ' 43'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1304.5690
month: '02'
oa: 1
oa_version: Preprint
page: 382 - 421
publication: Annals of Statistics
publication_status: published
publisher: Institute of Mathematical Statistics
publist_id: '5672'
quality_controlled: '1'
status: public
title: Universality for the largest eigenvalue of sample covariance matrices with
general population
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 43
year: '2015'
...
---
_id: '1508'
abstract:
- lang: eng
text: We consider generalized Wigner ensembles and general β-ensembles with analytic
potentials for any β ≥ 1. The recent universality results in particular assert
that the local averages of consecutive eigenvalue gaps in the bulk of the spectrum
are universal in the sense that they coincide with those of the corresponding
Gaussian β-ensembles. In this article, we show that local averaging is not necessary
for this result, i.e. we prove that the single gap distributions in the bulk are
universal. In fact, with an additional step, our result can be extended to any
C4(ℝ) potential.
author:
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
- first_name: Horng
full_name: Yau, Horng
last_name: Yau
citation:
ama: Erdös L, Yau H. Gap universality of generalized Wigner and β ensembles. Journal
of the European Mathematical Society. 2015;17(8):1927-2036. doi:10.4171/JEMS/548
apa: Erdös, L., & Yau, H. (2015). Gap universality of generalized Wigner and
β ensembles. Journal of the European Mathematical Society. European Mathematical
Society. https://doi.org/10.4171/JEMS/548
chicago: Erdös, László, and Horng Yau. “Gap Universality of Generalized Wigner and
β Ensembles.” Journal of the European Mathematical Society. European Mathematical
Society, 2015. https://doi.org/10.4171/JEMS/548.
ieee: L. Erdös and H. Yau, “Gap universality of generalized Wigner and β ensembles,”
Journal of the European Mathematical Society, vol. 17, no. 8. European
Mathematical Society, pp. 1927–2036, 2015.
ista: Erdös L, Yau H. 2015. Gap universality of generalized Wigner and β ensembles.
Journal of the European Mathematical Society. 17(8), 1927–2036.
mla: Erdös, László, and Horng Yau. “Gap Universality of Generalized Wigner and β
Ensembles.” Journal of the European Mathematical Society, vol. 17, no.
8, European Mathematical Society, 2015, pp. 1927–2036, doi:10.4171/JEMS/548.
short: L. Erdös, H. Yau, Journal of the European Mathematical Society 17 (2015)
1927–2036.
date_created: 2018-12-11T11:52:26Z
date_published: 2015-08-01T00:00:00Z
date_updated: 2021-01-12T06:51:15Z
day: '01'
department:
- _id: LaEr
doi: 10.4171/JEMS/548
intvolume: ' 17'
issue: '8'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/1211.3786
month: '08'
oa: 1
oa_version: Preprint
page: 1927 - 2036
publication: Journal of the European Mathematical Society
publication_status: published
publisher: European Mathematical Society
publist_id: '5669'
quality_controlled: '1'
scopus_import: 1
status: public
title: Gap universality of generalized Wigner and β ensembles
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2015'
...
---
_id: '1506'
abstract:
- lang: eng
text: Consider the square random matrix An = (aij)n,n, where {aij:= a(n)ij , i,
j = 1, . . . , n} is a collection of independent real random variables with means
zero and variances one. Under the additional moment condition supn max1≤i,j ≤n
Ea4ij <∞, we prove Girko's logarithmic law of det An in the sense that as n→∞
log | detAn| ? (1/2) log(n-1)! d/→√(1/2) log n N(0, 1).
author:
- first_name: Zhigang
full_name: Bao, Zhigang
id: 442E6A6C-F248-11E8-B48F-1D18A9856A87
last_name: Bao
orcid: 0000-0003-3036-1475
- first_name: Guangming
full_name: Pan, Guangming
last_name: Pan
- first_name: Wang
full_name: Zhou, Wang
last_name: Zhou
citation:
ama: Bao Z, Pan G, Zhou W. The logarithmic law of random determinant. Bernoulli.
2015;21(3):1600-1628. doi:10.3150/14-BEJ615
apa: Bao, Z., Pan, G., & Zhou, W. (2015). The logarithmic law of random determinant.
Bernoulli. Bernoulli Society for Mathematical Statistics and Probability.
https://doi.org/10.3150/14-BEJ615
chicago: Bao, Zhigang, Guangming Pan, and Wang Zhou. “The Logarithmic Law of Random
Determinant.” Bernoulli. Bernoulli Society for Mathematical Statistics
and Probability, 2015. https://doi.org/10.3150/14-BEJ615.
ieee: Z. Bao, G. Pan, and W. Zhou, “The logarithmic law of random determinant,”
Bernoulli, vol. 21, no. 3. Bernoulli Society for Mathematical Statistics
and Probability, pp. 1600–1628, 2015.
ista: Bao Z, Pan G, Zhou W. 2015. The logarithmic law of random determinant. Bernoulli.
21(3), 1600–1628.
mla: Bao, Zhigang, et al. “The Logarithmic Law of Random Determinant.” Bernoulli,
vol. 21, no. 3, Bernoulli Society for Mathematical Statistics and Probability,
2015, pp. 1600–28, doi:10.3150/14-BEJ615.
short: Z. Bao, G. Pan, W. Zhou, Bernoulli 21 (2015) 1600–1628.
date_created: 2018-12-11T11:52:25Z
date_published: 2015-08-01T00:00:00Z
date_updated: 2021-01-12T06:51:14Z
day: '01'
department:
- _id: LaEr
doi: 10.3150/14-BEJ615
intvolume: ' 21'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/1208.5823
month: '08'
oa: 1
oa_version: Preprint
page: 1600 - 1628
publication: Bernoulli
publication_status: published
publisher: Bernoulli Society for Mathematical Statistics and Probability
publist_id: '5671'
quality_controlled: '1'
status: public
title: The logarithmic law of random determinant
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 21
year: '2015'
...
---
_id: '1513'
abstract:
- lang: eng
text: "Insects of the order Hemiptera (true bugs) use a wide range of mechanisms
of sex determination, including genetic sex determination, paternal genome elimination,
and haplodiploidy. Genetic sex determination, the prevalent mode, is generally
controlled by a pair of XY sex chromosomes or by an XX/X0 system, but different
configurations that include additional sex chromosomes are also present. Although
this diversity of sex determining systems has been extensively studied at the
cytogenetic level, only the X chromosome of the model pea aphid Acyrthosiphon
pisum has been analyzed at the genomic level, and little is known about X chromosome
biology in the rest of the order.\r\n\r\nIn this study, we take advantage of published
DNA- and RNA-seq data from three additional Hemiptera species to perform a comparative
analysis of the gene content and expression of the X chromosome throughout this
clade. We find that, despite showing evidence of dosage compensation, the X chromosomes
of these species show female-biased expression, and a deficit of male-biased genes,
in direct contrast to the pea aphid X. We further detect an excess of shared gene
content between these very distant species, suggesting that despite the diversity
of sex determining systems, the same chromosomal element is used as the X throughout
a large portion of the order. "
article_processing_charge: No
author:
- first_name: Arka
full_name: Pal, Arka
id: 6AAB2240-CA9A-11E9-9C1A-D9D1E5697425
last_name: Pal
- first_name: Beatriz
full_name: Vicoso, Beatriz
id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
last_name: Vicoso
orcid: 0000-0002-4579-8306
citation:
ama: 'Pal A, Vicoso B. The X chromosome of hemipteran insects: Conservation, dosage
compensation and sex-biased expression. Genome Biology and Evolution. 2015;7(12):3259-3268.
doi:10.1093/gbe/evv215'
apa: 'Pal, A., & Vicoso, B. (2015). The X chromosome of hemipteran insects:
Conservation, dosage compensation and sex-biased expression. Genome Biology
and Evolution. Oxford University Press. https://doi.org/10.1093/gbe/evv215'
chicago: 'Pal, Arka, and Beatriz Vicoso. “The X Chromosome of Hemipteran Insects:
Conservation, Dosage Compensation and Sex-Biased Expression.” Genome Biology
and Evolution. Oxford University Press, 2015. https://doi.org/10.1093/gbe/evv215.'
ieee: 'A. Pal and B. Vicoso, “The X chromosome of hemipteran insects: Conservation,
dosage compensation and sex-biased expression,” Genome Biology and Evolution,
vol. 7, no. 12. Oxford University Press, pp. 3259–3268, 2015.'
ista: 'Pal A, Vicoso B. 2015. The X chromosome of hemipteran insects: Conservation,
dosage compensation and sex-biased expression. Genome Biology and Evolution. 7(12),
3259–3268.'
mla: 'Pal, Arka, and Beatriz Vicoso. “The X Chromosome of Hemipteran Insects: Conservation,
Dosage Compensation and Sex-Biased Expression.” Genome Biology and Evolution,
vol. 7, no. 12, Oxford University Press, 2015, pp. 3259–68, doi:10.1093/gbe/evv215.'
short: A. Pal, B. Vicoso, Genome Biology and Evolution 7 (2015) 3259–3268.
date_created: 2018-12-11T11:52:27Z
date_published: 2015-12-01T00:00:00Z
date_updated: 2021-01-12T06:51:18Z
day: '01'
ddc:
- '570'
department:
- _id: BeVi
doi: 10.1093/gbe/evv215
ec_funded: 1
file:
- access_level: open_access
checksum: 2b56b8c2e2a1d4cc3c9cb8daba26dd9b
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:17:29Z
date_updated: 2020-07-14T12:45:00Z
file_id: '5284'
file_name: IST-2016-496-v1+1_Genome_Biol_Evol-2015-Pal-3259-68.pdf
file_size: 858027
relation: main_file
file_date_updated: 2020-07-14T12:45:00Z
has_accepted_license: '1'
intvolume: ' 7'
issue: '12'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: 3259 - 3268
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication: Genome Biology and Evolution
publication_status: published
publisher: Oxford University Press
publist_id: '5664'
pubrep_id: '496'
quality_controlled: '1'
scopus_import: 1
status: public
title: 'The X chromosome of hemipteran insects: Conservation, dosage compensation
and sex-biased expression'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 7
year: '2015'
...
---
_id: '1517'
abstract:
- lang: eng
text: "We study the large deviation rate functional for the empirical distribution
of independent Brownian particles with drift. In one dimension, it has been shown
by Adams, Dirr, Peletier and Zimmer that this functional is asymptotically equivalent
(in the sense of Γ-convergence) to the Jordan-Kinderlehrer-Otto functional arising
in the Wasserstein gradient flow structure of the Fokker-Planck equation. In higher
dimensions, part of this statement (the lower bound) has been recently proved
by Duong, Laschos and Renger, but the upper bound remained open, since the proof
of Duong et al relies on regularity properties of optimal transport maps that
are restricted to one dimension. In this note we present a new proof of the upper
bound, thereby generalising the result of Adams et al to arbitrary dimensions.\r\n"
article_number: '89'
author:
- first_name: Matthias
full_name: Erbar, Matthias
last_name: Erbar
- first_name: Jan
full_name: Maas, Jan
id: 4C5696CE-F248-11E8-B48F-1D18A9856A87
last_name: Maas
orcid: 0000-0002-0845-1338
- first_name: Michiel
full_name: Renger, Michiel
last_name: Renger
citation:
ama: Erbar M, Maas J, Renger M. From large deviations to Wasserstein gradient flows
in multiple dimensions. Electronic Communications in Probability. 2015;20.
doi:10.1214/ECP.v20-4315
apa: Erbar, M., Maas, J., & Renger, M. (2015). From large deviations to Wasserstein
gradient flows in multiple dimensions. Electronic Communications in Probability.
Institute of Mathematical Statistics. https://doi.org/10.1214/ECP.v20-4315
chicago: Erbar, Matthias, Jan Maas, and Michiel Renger. “From Large Deviations to
Wasserstein Gradient Flows in Multiple Dimensions.” Electronic Communications
in Probability. Institute of Mathematical Statistics, 2015. https://doi.org/10.1214/ECP.v20-4315.
ieee: M. Erbar, J. Maas, and M. Renger, “From large deviations to Wasserstein gradient
flows in multiple dimensions,” Electronic Communications in Probability,
vol. 20. Institute of Mathematical Statistics, 2015.
ista: Erbar M, Maas J, Renger M. 2015. From large deviations to Wasserstein gradient
flows in multiple dimensions. Electronic Communications in Probability. 20, 89.
mla: Erbar, Matthias, et al. “From Large Deviations to Wasserstein Gradient Flows
in Multiple Dimensions.” Electronic Communications in Probability, vol.
20, 89, Institute of Mathematical Statistics, 2015, doi:10.1214/ECP.v20-4315.
short: M. Erbar, J. Maas, M. Renger, Electronic Communications in Probability 20
(2015).
date_created: 2018-12-11T11:52:29Z
date_published: 2015-11-29T00:00:00Z
date_updated: 2021-01-12T06:51:19Z
day: '29'
ddc:
- '519'
department:
- _id: JaMa
doi: 10.1214/ECP.v20-4315
file:
- access_level: open_access
checksum: 135741c17d3e1547ca696b6fbdcd559c
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:10:39Z
date_updated: 2020-07-14T12:45:00Z
file_id: '4828'
file_name: IST-2016-494-v1+1_4315-23820-1-PB.pdf
file_size: 230525
relation: main_file
file_date_updated: 2020-07-14T12:45:00Z
has_accepted_license: '1'
intvolume: ' 20'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
publication: Electronic Communications in Probability
publication_status: published
publisher: Institute of Mathematical Statistics
publist_id: '5660'
pubrep_id: '494'
quality_controlled: '1'
scopus_import: 1
status: public
title: From large deviations to Wasserstein gradient flows in multiple dimensions
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 20
year: '2015'
...
---
_id: '1515'
abstract:
- lang: eng
text: Type 1 metabotropic glutamate (mGlu1) receptors play a pivotal role in different
forms of synaptic plasticity in the cerebellar cortex, e.g. long-term depression
at glutamatergic synapses and rebound potentiation at GABAergic synapses. These
various forms of plasticity might depend on the subsynaptic arrangement of the
receptor in Purkinje cells that can be regulated by protein-protein interactions.
This study investigated, by means of the freeze-fracture replica immunogold labelling
method, the subcellular localization of mGlu1 receptors in the rodent cerebellum
and whether Homer proteins regulate their subsynaptic distribution. We observed
a widespread extrasynaptic localization of mGlu1 receptors and confirmed their
peri-synaptic enrichment at glutamatergic synapses. Conversely, we detected mGlu1
receptors within the main body of GABAergic synapses onto Purkinje cell dendrites.
Although Homer proteins are known to interact with the mGlu1 receptor C-terminus,
we could not detect Homer3, the most abundant Homer protein in the cerebellar
cortex, at GABAergic synapses by pre-embedding and post-embedding immunoelectron
microscopy. We then hypothesized a critical role for Homer proteins in the peri-junctional
localization of mGlu1 receptors at glutamatergic synapses. To disrupt Homer-associated
protein complexes, mice were tail-vein injected with the membrane-permeable dominant-negative
TAT-Homer1a. Freeze-fracture replica immunogold labelling analysis showed no significant
alteration in the mGlu1 receptor distribution pattern at parallel fibre-Purkinje
cell synapses, suggesting that other scaffolding proteins are involved in the
peri-synaptic confinement. The identification of interactors that regulate the
subsynaptic localization of the mGlu1 receptor at neurochemically distinct synapses
may offer new insight into its trafficking and intracellular signalling.
acknowledgement: This work was supported by the Austrian Science Fund (FWF) (project
W012060-10 to F.F.), The Japan Society for the Promotion of Science (JSPS) (to R.S.)
and Agence Nationale de la Recherche (ANR-11-BSV4-018-03, DELTAPLAN), Région Languedoc-Roussillon
(Chercheur d’Avenir) (to J.P.). The authors thank S. Schönherr for excellent technical
support and Dr Furuichi for kindly providing anti-Homer3 antibodies.
author:
- first_name: Mahnaz
full_name: Mansouri, Mahnaz
last_name: Mansouri
- first_name: Yu
full_name: Kasugai, Yu
last_name: Kasugai
- first_name: Yugo
full_name: Fukazawa, Yugo
last_name: Fukazawa
- first_name: Federica
full_name: Bertaso, Federica
last_name: Bertaso
- first_name: Fabrice
full_name: Raynaud, Fabrice
last_name: Raynaud
- first_name: Julie
full_name: Perroy, Julie
last_name: Perroy
- first_name: Laurent
full_name: Fagni, Laurent
last_name: Fagni
- first_name: Walter
full_name: Walter Kaufmann
id: 3F99E422-F248-11E8-B48F-1D18A9856A87
last_name: Kaufmann
orcid: 0000-0001-9735-5315
- first_name: Masahiko
full_name: Watanabe, Masahiko
last_name: Watanabe
- first_name: Ryuichi
full_name: Ryuichi Shigemoto
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Francesco
full_name: Ferraguti, Francesco
last_name: Ferraguti
citation:
ama: Mansouri M, Kasugai Y, Fukazawa Y, et al. Distinct subsynaptic localization
of type 1 metabotropic glutamate receptors at glutamatergic and GABAergic synapses
in the rodent cerebellar cortex. European Journal of Neuroscience. 2015;41(2):157-167.
doi:10.1111/ejn.12779
apa: Mansouri, M., Kasugai, Y., Fukazawa, Y., Bertaso, F., Raynaud, F., Perroy,
J., … Ferraguti, F. (2015). Distinct subsynaptic localization of type 1 metabotropic
glutamate receptors at glutamatergic and GABAergic synapses in the rodent cerebellar
cortex. European Journal of Neuroscience. Wiley-Blackwell. https://doi.org/10.1111/ejn.12779
chicago: Mansouri, Mahnaz, Yu Kasugai, Yugo Fukazawa, Federica Bertaso, Fabrice
Raynaud, Julie Perroy, Laurent Fagni, et al. “Distinct Subsynaptic Localization
of Type 1 Metabotropic Glutamate Receptors at Glutamatergic and GABAergic Synapses
in the Rodent Cerebellar Cortex.” European Journal of Neuroscience. Wiley-Blackwell,
2015. https://doi.org/10.1111/ejn.12779.
ieee: M. Mansouri et al., “Distinct subsynaptic localization of type 1 metabotropic
glutamate receptors at glutamatergic and GABAergic synapses in the rodent cerebellar
cortex,” European Journal of Neuroscience, vol. 41, no. 2. Wiley-Blackwell,
pp. 157–167, 2015.
ista: Mansouri M, Kasugai Y, Fukazawa Y, Bertaso F, Raynaud F, Perroy J, Fagni L,
Kaufmann W, Watanabe M, Shigemoto R, Ferraguti F. 2015. Distinct subsynaptic localization
of type 1 metabotropic glutamate receptors at glutamatergic and GABAergic synapses
in the rodent cerebellar cortex. European Journal of Neuroscience. 41(2), 157–167.
mla: Mansouri, Mahnaz, et al. “Distinct Subsynaptic Localization of Type 1 Metabotropic
Glutamate Receptors at Glutamatergic and GABAergic Synapses in the Rodent Cerebellar
Cortex.” European Journal of Neuroscience, vol. 41, no. 2, Wiley-Blackwell,
2015, pp. 157–67, doi:10.1111/ejn.12779.
short: M. Mansouri, Y. Kasugai, Y. Fukazawa, F. Bertaso, F. Raynaud, J. Perroy,
L. Fagni, W. Kaufmann, M. Watanabe, R. Shigemoto, F. Ferraguti, European Journal
of Neuroscience 41 (2015) 157–167.
date_created: 2018-12-11T11:52:28Z
date_published: 2015-01-01T00:00:00Z
date_updated: 2023-02-23T10:02:24Z
day: '01'
doi: 10.1111/ejn.12779
extern: 1
intvolume: ' 41'
issue: '2'
month: '01'
page: 157 - 167
publication: European Journal of Neuroscience
publication_status: published
publisher: Wiley-Blackwell
publist_id: '5662'
quality_controlled: 0
status: public
title: Distinct subsynaptic localization of type 1 metabotropic glutamate receptors
at glutamatergic and GABAergic synapses in the rodent cerebellar cortex
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
volume: 41
year: '2015'
...
---
_id: '1514'
abstract:
- lang: eng
text: 'Endocannabinoids (eCBs) play key roles in brain function, acting as modulatory
signals in synaptic transmission and plasticity. They are recognized as retrograde
messengers that mediate long-term synaptic depression (LTD), but their ability
to induce long-term potentiation (LTP) is poorly known. We show that eCBs induce
the long-term enhancement of transmitter release at single hippocampal synapses
through stimulation of astrocytes when coincident with postsynaptic activity.
This LTP requires the coordinated activity of the 3 elements of the tripartite
synapse: 1) eCB-evoked astrocyte calcium signal that stimulates glutamate release;
2) postsynaptic nitric oxide production; and 3) activation of protein kinase C
and presynaptic group I metabotropic glutamate receptors, whose location at presynaptic
sites was confirmed by immunoelectron microscopy. Hence, while eCBs act as retrograde
signals to depress homoneuronal synapses, they serve as lateral messengers to
induce LTP in distant heteroneuronal synapses through stimulation of astrocytes.
Therefore, eCBs can trigger LTP through stimulation of astrocyte-neuron signaling,
revealing novel cellular mechanisms of eCB effects on synaptic plasticity.'
acknowledgement: |-
This work was supported by grants from Ministerio de Economia y Competitividad, Spain (MINECO; BFU2010-15832), European Union (HEALTH-F2-2007-202167), and Cajal Blue Brain to A.A. Grants from Spain (MINECO; BFU-2009-08404 and
CSD2008-00005) to R.L. Grants from Spain (MINECO; Consolider, CSD2010-00045; Ramón y Cajal Program, RYC-2012-12014; and BFU2013-47265) to G.P. We thank Dr Atsu Aiba (Animal Resources, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, University of Tokyo) for the donation of the mGluR1b rescue mice.
author:
- first_name: Marta
full_name: Gómez-Gonzalo, Marta
last_name: Gómez Gonzalo
- first_name: Marta
full_name: Navarrete, Marta
last_name: Navarrete
- first_name: Gertrudis
full_name: Perea, Gertrudis
last_name: Perea
- first_name: Ana
full_name: Covelo, Ana
last_name: Covelo
- first_name: Mario
full_name: Martín-Fernández, Mario
last_name: Martín Fernández
- first_name: Ryuichi
full_name: Ryuichi Shigemoto
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Rafael
full_name: Luján, Rafael
last_name: Luján
- first_name: Alfonso
full_name: Araque, Alfonso
last_name: Araque
citation:
ama: Gómez Gonzalo M, Navarrete M, Perea G, et al. Endocannabinoids induce lateral
long term potentiation of transmitter release by stimulation of gliotransmission.
Cerebral Cortex. 2015;25(10):3699-3712. doi:10.1093/cercor/bhu231
apa: Gómez Gonzalo, M., Navarrete, M., Perea, G., Covelo, A., Martín Fernández,
M., Shigemoto, R., … Araque, A. (2015). Endocannabinoids induce lateral long term
potentiation of transmitter release by stimulation of gliotransmission. Cerebral
Cortex. Oxford University Press. https://doi.org/10.1093/cercor/bhu231
chicago: Gómez Gonzalo, Marta, Marta Navarrete, Gertrudis Perea, Ana Covelo, Mario
Martín Fernández, Ryuichi Shigemoto, Rafael Luján, and Alfonso Araque. “Endocannabinoids
Induce Lateral Long Term Potentiation of Transmitter Release by Stimulation of
Gliotransmission.” Cerebral Cortex. Oxford University Press, 2015. https://doi.org/10.1093/cercor/bhu231.
ieee: M. Gómez Gonzalo et al., “Endocannabinoids induce lateral long term
potentiation of transmitter release by stimulation of gliotransmission,” Cerebral
Cortex, vol. 25, no. 10. Oxford University Press, pp. 3699–3712, 2015.
ista: Gómez Gonzalo M, Navarrete M, Perea G, Covelo A, Martín Fernández M, Shigemoto
R, Luján R, Araque A. 2015. Endocannabinoids induce lateral long term potentiation
of transmitter release by stimulation of gliotransmission. Cerebral Cortex. 25(10),
3699–3712.
mla: Gómez Gonzalo, Marta, et al. “Endocannabinoids Induce Lateral Long Term Potentiation
of Transmitter Release by Stimulation of Gliotransmission.” Cerebral Cortex,
vol. 25, no. 10, Oxford University Press, 2015, pp. 3699–712, doi:10.1093/cercor/bhu231.
short: M. Gómez Gonzalo, M. Navarrete, G. Perea, A. Covelo, M. Martín Fernández,
R. Shigemoto, R. Luján, A. Araque, Cerebral Cortex 25 (2015) 3699–3712.
date_created: 2018-12-11T11:52:27Z
date_published: 2015-10-10T00:00:00Z
date_updated: 2021-01-12T06:51:18Z
day: '10'
doi: 10.1093/cercor/bhu231
extern: 1
intvolume: ' 25'
issue: '10'
month: '10'
page: 3699 - 3712
publication: Cerebral Cortex
publication_status: published
publisher: Oxford University Press
publist_id: '5663'
quality_controlled: 0
status: public
title: Endocannabinoids induce lateral long term potentiation of transmitter release
by stimulation of gliotransmission
type: journal_article
volume: 25
year: '2015'
...
---
_id: '1519'
abstract:
- lang: eng
text: Evolutionary biologists have an array of powerful theoretical techniques that
can accurately predict changes in the genetic composition of populations. Changes
in gene frequencies and genetic associations between loci can be tracked as they
respond to a wide variety of evolutionary forces. However, it is often less clear
how to decompose these various forces into components that accurately reflect
the underlying biology. Here, we present several issues that arise in the definition
and interpretation of selection and selection coefficients, focusing on insights
gained through the examination of selection coefficients in multilocus notation.
Using this notation, we discuss how its flexibility-which allows different biological
units to be identified as targets of selection-is reflected in the interpretation
of the coefficients that the notation generates. In many situations, it can be
difficult to agree on whether loci can be considered to be under "direct"
versus "indirect" selection, or to quantify this selection. We present
arguments for what the terms direct and indirect selection might best encompass,
considering a range of issues, from viability and sexual selection to kin selection.
We show how multilocus notation can discriminate between direct and indirect selection,
and describe when it can do so.
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Maria
full_name: Servedio, Maria
last_name: Servedio
citation:
ama: Barton NH, Servedio M. The interpretation of selection coefficients. Evolution.
2015;69(5):1101-1112. doi:10.1111/evo.12641
apa: Barton, N. H., & Servedio, M. (2015). The interpretation of selection coefficients.
Evolution. Wiley. https://doi.org/10.1111/evo.12641
chicago: Barton, Nicholas H, and Maria Servedio. “The Interpretation of Selection
Coefficients.” Evolution. Wiley, 2015. https://doi.org/10.1111/evo.12641.
ieee: N. H. Barton and M. Servedio, “The interpretation of selection coefficients,”
Evolution, vol. 69, no. 5. Wiley, pp. 1101–1112, 2015.
ista: Barton NH, Servedio M. 2015. The interpretation of selection coefficients.
Evolution. 69(5), 1101–1112.
mla: Barton, Nicholas H., and Maria Servedio. “The Interpretation of Selection Coefficients.”
Evolution, vol. 69, no. 5, Wiley, 2015, pp. 1101–12, doi:10.1111/evo.12641.
short: N.H. Barton, M. Servedio, Evolution 69 (2015) 1101–1112.
date_created: 2018-12-11T11:52:29Z
date_published: 2015-03-19T00:00:00Z
date_updated: 2021-01-12T06:51:20Z
day: '19'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.1111/evo.12641
ec_funded: 1
file:
- access_level: open_access
checksum: fd8d23f476bc194419929b72ca265c02
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:10:34Z
date_updated: 2020-07-14T12:45:00Z
file_id: '4822'
file_name: IST-2016-560-v1+1_Interpreting_ML_coefficients_11.2.15_App.pdf
file_size: 188872
relation: main_file
- access_level: open_access
checksum: b774911e70044641d556e258efcb52ef
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:10:35Z
date_updated: 2020-07-14T12:45:00Z
file_id: '4823'
file_name: IST-2016-560-v1+2_Interpreting_ML_coefficients_11.2.15_mainText.pdf
file_size: 577415
relation: main_file
file_date_updated: 2020-07-14T12:45:00Z
has_accepted_license: '1'
intvolume: ' 69'
issue: '5'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Submitted Version
page: 1101 - 1112
project:
- _id: 25B07788-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '250152'
name: Limits to selection in biology and in evolutionary computation
publication: Evolution
publication_status: published
publisher: Wiley
publist_id: '5656'
pubrep_id: '560'
quality_controlled: '1'
scopus_import: 1
status: public
title: The interpretation of selection coefficients
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 69
year: '2015'
...
---
_id: '1525'
abstract:
- lang: eng
text: 'Based on 16 recommendations, efforts should be made to achieve the following
goal: By 2025, all scholarly publication activity in Austria should be Open Access.
In other words, the final versions of all scholarly publications resulting from
the support of public resources must be freely accessible on the Internet without
delay (Gold Open Access). The resources required to meet this obligation shall
be provided to the authors, or the cost of the publication venues shall be borne
directly by the research organisations.'
article_processing_charge: No
article_type: original
author:
- first_name: Bruno
full_name: Bauer, Bruno
last_name: Bauer
- first_name: Guido
full_name: Blechl, Guido
last_name: Blechl
- first_name: Christoph
full_name: Bock, Christoph
last_name: Bock
- first_name: Patrick
full_name: Danowski, Patrick
id: 2EBD1598-F248-11E8-B48F-1D18A9856A87
last_name: Danowski
orcid: 0000-0002-6026-4409
- first_name: Andreas
full_name: Ferus, Andreas
last_name: Ferus
- first_name: Anton
full_name: Graschopf, Anton
last_name: Graschopf
- first_name: Thomas
full_name: König, Thomas
last_name: König
- first_name: Katja
full_name: Mayer, Katja
last_name: Mayer
- first_name: Falk
full_name: Reckling, Falk
last_name: Reckling
- first_name: Katharina
full_name: Rieck, Katharina
last_name: Rieck
- first_name: Peter
full_name: Seitz, Peter
last_name: Seitz
- first_name: Herwig
full_name: Stöger, Herwig
last_name: Stöger
- first_name: Elvira
full_name: Welzig, Elvira
last_name: Welzig
citation:
ama: Bauer B, Blechl G, Bock C, et al. Arbeitsgruppe „Nationale Strategie“ des Open
Access Network Austria OANA. VÖB Mitteilungen. 2015;68(3):580-607. doi:10.5281/zenodo.33178
apa: Bauer, B., Blechl, G., Bock, C., Danowski, P., Ferus, A., Graschopf, A., …
Welzig, E. (2015). Arbeitsgruppe „Nationale Strategie“ des Open Access Network
Austria OANA. VÖB Mitteilungen. Verein Österreichischer Bibliothekare.
https://doi.org/10.5281/zenodo.33178
chicago: Bauer, Bruno, Guido Blechl, Christoph Bock, Patrick Danowski, Andreas Ferus,
Anton Graschopf, Thomas König, et al. “Arbeitsgruppe „Nationale Strategie“ Des
Open Access Network Austria OANA.” VÖB Mitteilungen. Verein Österreichischer
Bibliothekare, 2015. https://doi.org/10.5281/zenodo.33178.
ieee: B. Bauer et al., “Arbeitsgruppe „Nationale Strategie“ des Open Access
Network Austria OANA,” VÖB Mitteilungen, vol. 68, no. 3. Verein Österreichischer
Bibliothekare, pp. 580–607, 2015.
ista: Bauer B, Blechl G, Bock C, Danowski P, Ferus A, Graschopf A, König T, Mayer
K, Reckling F, Rieck K, Seitz P, Stöger H, Welzig E. 2015. Arbeitsgruppe „Nationale
Strategie“ des Open Access Network Austria OANA. VÖB Mitteilungen. 68(3), 580–607.
mla: Bauer, Bruno, et al. “Arbeitsgruppe „Nationale Strategie“ Des Open Access Network
Austria OANA.” VÖB Mitteilungen, vol. 68, no. 3, Verein Österreichischer
Bibliothekare, 2015, pp. 580–607, doi:10.5281/zenodo.33178.
short: B. Bauer, G. Blechl, C. Bock, P. Danowski, A. Ferus, A. Graschopf, T. König,
K. Mayer, F. Reckling, K. Rieck, P. Seitz, H. Stöger, E. Welzig, VÖB Mitteilungen
68 (2015) 580–607.
date_created: 2018-12-11T11:52:31Z
date_published: 2015-11-12T00:00:00Z
date_updated: 2021-01-12T06:51:22Z
day: '12'
ddc:
- '020'
department:
- _id: E-Lib
doi: 10.5281/zenodo.33178
file:
- access_level: open_access
checksum: a495fe253bbc7615b1d60e9e85c94408
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:17:59Z
date_updated: 2020-07-14T12:45:00Z
file_id: '5317'
file_name: IST-2016-720-v1+1_OANA_OA-Empfehlungen_12-11-2015.pdf
file_size: 931707
relation: main_file
file_date_updated: 2020-07-14T12:45:00Z
has_accepted_license: '1'
intvolume: ' 68'
issue: '3'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
page: 580 - 607
publication: VÖB Mitteilungen
publication_status: published
publisher: Verein Österreichischer Bibliothekare
publist_id: '5648'
pubrep_id: '720'
quality_controlled: '1'
scopus_import: 1
status: public
title: Arbeitsgruppe „Nationale Strategie“ des Open Access Network Austria OANA
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 68
year: '2015'
...
---
_id: '1520'
abstract:
- lang: eng
text: Creating mechanical automata that can walk in stable and pleasing manners
is a challenging task that requires both skill and expertise. We propose to use
computational design to offset the technical difficulties of this process. A simple
drag-and-drop interface allows casual users to create personalized walking toys
from a library of pre-defined template mechanisms. Provided with this input, our
method leverages physical simulation and evolutionary optimization to refine the
mechanical designs such that the resulting toys are able to walk. The optimization
process is guided by an intuitive set of objectives that measure the quality of
the walking motions. We demonstrate our approach on a set of simulated mechanical
toys with different numbers of legs and various distinct gaits. Two fabricated
prototypes showcase the feasibility of our designs.
author:
- first_name: Gaurav
full_name: Bharaj, Gaurav
last_name: Bharaj
- first_name: Stelian
full_name: Coros, Stelian
last_name: Coros
- first_name: Bernhard
full_name: Thomaszewski, Bernhard
last_name: Thomaszewski
- first_name: James
full_name: Tompkin, James
last_name: Tompkin
- first_name: Bernd
full_name: Bickel, Bernd
id: 49876194-F248-11E8-B48F-1D18A9856A87
last_name: Bickel
orcid: 0000-0001-6511-9385
- first_name: Hanspeter
full_name: Pfister, Hanspeter
last_name: Pfister
citation:
ama: 'Bharaj G, Coros S, Thomaszewski B, Tompkin J, Bickel B, Pfister H. Computational
design of walking automata. In: ACM; 2015:93-100. doi:10.1145/2786784.2786803'
apa: 'Bharaj, G., Coros, S., Thomaszewski, B., Tompkin, J., Bickel, B., & Pfister,
H. (2015). Computational design of walking automata (pp. 93–100). Presented at
the SCA: ACM SIGGRAPH/Eurographics Symposium on Computer animation, Los Angeles,
CA, United States: ACM. https://doi.org/10.1145/2786784.2786803'
chicago: Bharaj, Gaurav, Stelian Coros, Bernhard Thomaszewski, James Tompkin, Bernd
Bickel, and Hanspeter Pfister. “Computational Design of Walking Automata,” 93–100.
ACM, 2015. https://doi.org/10.1145/2786784.2786803.
ieee: 'G. Bharaj, S. Coros, B. Thomaszewski, J. Tompkin, B. Bickel, and H. Pfister,
“Computational design of walking automata,” presented at the SCA: ACM SIGGRAPH/Eurographics
Symposium on Computer animation, Los Angeles, CA, United States, 2015, pp. 93–100.'
ista: 'Bharaj G, Coros S, Thomaszewski B, Tompkin J, Bickel B, Pfister H. 2015.
Computational design of walking automata. SCA: ACM SIGGRAPH/Eurographics Symposium
on Computer animation, 93–100.'
mla: Bharaj, Gaurav, et al. Computational Design of Walking Automata. ACM,
2015, pp. 93–100, doi:10.1145/2786784.2786803.
short: G. Bharaj, S. Coros, B. Thomaszewski, J. Tompkin, B. Bickel, H. Pfister,
in:, ACM, 2015, pp. 93–100.
conference:
end_date: 2015-08-09
location: Los Angeles, CA, United States
name: 'SCA: ACM SIGGRAPH/Eurographics Symposium on Computer animation'
start_date: 2015-08-07
date_created: 2018-12-11T11:52:30Z
date_published: 2015-08-01T00:00:00Z
date_updated: 2021-01-12T06:51:21Z
day: '01'
department:
- _id: BeBi
doi: 10.1145/2786784.2786803
language:
- iso: eng
month: '08'
oa_version: None
page: 93 - 100
publication_identifier:
isbn:
- 978-1-4503-3496-9
publication_status: published
publisher: ACM
publist_id: '5655'
quality_controlled: '1'
scopus_import: 1
status: public
title: Computational design of walking automata
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2015'
...
---
_id: '1532'
abstract:
- lang: eng
text: Ammonium is the major nitrogen source in some plant ecosystems but is toxic
at high concentrations, especially when available as the exclusive nitrogen source.
Ammonium stress rapidly leads to various metabolic and hormonal imbalances that
ultimately inhibit root and shoot growth in many plant species, including Arabidopsis
thaliana (L.) Heynh. To identify molecular and genetic factors involved in seedling
survival with prolonged exclusive NH4+ nutrition, a transcriptomic analysis with
microarrays was used. Substantial transcriptional differences were most pronounced
in (NH4)2SO4-grown seedlings, compared with plants grown on KNO3 or NH4NO3. Consistent
with previous physiological analyses, major differences in the expression modules
of photosynthesis-related genes, an altered mitochondrial metabolism, differential
expression of the primary NH4+ assimilation, alteration of transporter gene expression
and crucial changes in cell wall biosynthesis were found. A major difference in
plant hormone responses, particularly of auxin but not cytokinin, was striking.
The activity of the DR5::GUS reporter revealed a dramatically decreased auxin
response in (NH4)2SO4-grown primary roots. The impaired root growth on (NH4)2SO4
was partially rescued by exogenous auxin or in specific mutants in the auxin pathway.
The data suggest that NH4+-induced nutritional and metabolic imbalances can be
partially overcome by elevated auxin levels.
article_processing_charge: No
article_type: original
author:
- first_name: Huaiyu
full_name: Yang, Huaiyu
last_name: Yang
- first_name: Jenny
full_name: Von Der Fecht Bartenbach, Jenny
last_name: Von Der Fecht Bartenbach
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Jan
full_name: Lohmann, Jan
last_name: Lohmann
- first_name: Benjamin
full_name: Neuhäuser, Benjamin
last_name: Neuhäuser
- first_name: Uwe
full_name: Ludewig, Uwe
last_name: Ludewig
citation:
ama: Yang H, Von Der Fecht Bartenbach J, Friml J, Lohmann J, Neuhäuser B, Ludewig
U. Auxin-modulated root growth inhibition in Arabidopsis thaliana seedlings with
ammonium as the sole nitrogen source. Functional Plant Biology. 2015;42(3):239-251.
doi:10.1071/FP14171
apa: Yang, H., Von Der Fecht Bartenbach, J., Friml, J., Lohmann, J., Neuhäuser,
B., & Ludewig, U. (2015). Auxin-modulated root growth inhibition in Arabidopsis
thaliana seedlings with ammonium as the sole nitrogen source. Functional Plant
Biology. CSIRO. https://doi.org/10.1071/FP14171
chicago: Yang, Huaiyu, Jenny Von Der Fecht Bartenbach, Jiří Friml, Jan Lohmann,
Benjamin Neuhäuser, and Uwe Ludewig. “Auxin-Modulated Root Growth Inhibition in
Arabidopsis Thaliana Seedlings with Ammonium as the Sole Nitrogen Source.” Functional
Plant Biology. CSIRO, 2015. https://doi.org/10.1071/FP14171.
ieee: H. Yang, J. Von Der Fecht Bartenbach, J. Friml, J. Lohmann, B. Neuhäuser,
and U. Ludewig, “Auxin-modulated root growth inhibition in Arabidopsis thaliana
seedlings with ammonium as the sole nitrogen source,” Functional Plant Biology,
vol. 42, no. 3. CSIRO, pp. 239–251, 2015.
ista: Yang H, Von Der Fecht Bartenbach J, Friml J, Lohmann J, Neuhäuser B, Ludewig
U. 2015. Auxin-modulated root growth inhibition in Arabidopsis thaliana seedlings
with ammonium as the sole nitrogen source. Functional Plant Biology. 42(3), 239–251.
mla: Yang, Huaiyu, et al. “Auxin-Modulated Root Growth Inhibition in Arabidopsis
Thaliana Seedlings with Ammonium as the Sole Nitrogen Source.” Functional Plant
Biology, vol. 42, no. 3, CSIRO, 2015, pp. 239–51, doi:10.1071/FP14171.
short: H. Yang, J. Von Der Fecht Bartenbach, J. Friml, J. Lohmann, B. Neuhäuser,
U. Ludewig, Functional Plant Biology 42 (2015) 239–251.
date_created: 2018-12-11T11:52:34Z
date_published: 2015-03-01T00:00:00Z
date_updated: 2022-05-24T09:02:24Z
day: '01'
department:
- _id: JiFr
doi: 10.1071/FP14171
external_id:
pmid:
- '32480670'
intvolume: ' 42'
issue: '3'
language:
- iso: eng
month: '03'
oa_version: None
page: 239 - 251
pmid: 1
publication: Functional Plant Biology
publication_identifier:
issn:
- 1445-4408
publication_status: published
publisher: CSIRO
publist_id: '5639'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Auxin-modulated root growth inhibition in Arabidopsis thaliana seedlings with
ammonium as the sole nitrogen source
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 42
year: '2015'
...
---
_id: '1531'
abstract:
- lang: eng
text: The Heat Kernel Signature (HKS) is a scalar quantity which is derived from
the heat kernel of a given shape. Due to its robustness, isometry invariance,
and multiscale nature, it has been successfully applied in many geometric applications.
From a more general point of view, the HKS can be considered as a descriptor of
the metric of a Riemannian manifold. Given a symmetric positive definite tensor
field we may interpret it as the metric of some Riemannian manifold and thereby
apply the HKS to visualize and analyze the given tensor data. In this paper, we
propose a generalization of this approach that enables the treatment of indefinite
tensor fields, like the stress tensor, by interpreting them as a generator of
a positive definite tensor field. To investigate the usefulness of this approach
we consider the stress tensor from the two-point-load model example and from a
mechanical work piece.
alternative_title:
- Mathematics and Visualization
article_processing_charge: No
author:
- first_name: Valentin
full_name: Zobel, Valentin
last_name: Zobel
- first_name: Jan
full_name: Reininghaus, Jan
id: 4505473A-F248-11E8-B48F-1D18A9856A87
last_name: Reininghaus
- first_name: Ingrid
full_name: Hotz, Ingrid
last_name: Hotz
citation:
ama: 'Zobel V, Reininghaus J, Hotz I. Visualizing symmetric indefinite 2D tensor
fields using The Heat Kernel Signature. In: Hotz I, Schultz T, eds. Visualization
and Processing of Higher Order Descriptors for Multi-Valued Data. Vol 40.
1st ed. Springer; 2015:257-267. doi:10.1007/978-3-319-15090-1_13'
apa: Zobel, V., Reininghaus, J., & Hotz, I. (2015). Visualizing symmetric indefinite
2D tensor fields using The Heat Kernel Signature. In I. Hotz & T. Schultz
(Eds.), Visualization and Processing of Higher Order Descriptors for Multi-Valued
Data (1st ed., Vol. 40, pp. 257–267). Springer. https://doi.org/10.1007/978-3-319-15090-1_13
chicago: Zobel, Valentin, Jan Reininghaus, and Ingrid Hotz. “Visualizing Symmetric
Indefinite 2D Tensor Fields Using The Heat Kernel Signature.” In Visualization
and Processing of Higher Order Descriptors for Multi-Valued Data, edited by
Ingrid Hotz and Thomas Schultz, 1st ed., 40:257–67. Springer, 2015. https://doi.org/10.1007/978-3-319-15090-1_13.
ieee: V. Zobel, J. Reininghaus, and I. Hotz, “Visualizing symmetric indefinite 2D
tensor fields using The Heat Kernel Signature,” in Visualization and Processing
of Higher Order Descriptors for Multi-Valued Data, 1st ed., vol. 40, I. Hotz
and T. Schultz, Eds. Springer, 2015, pp. 257–267.
ista: 'Zobel V, Reininghaus J, Hotz I. 2015.Visualizing symmetric indefinite 2D
tensor fields using The Heat Kernel Signature. In: Visualization and Processing
of Higher Order Descriptors for Multi-Valued Data. Mathematics and Visualization,
vol. 40, 257–267.'
mla: Zobel, Valentin, et al. “Visualizing Symmetric Indefinite 2D Tensor Fields
Using The Heat Kernel Signature.” Visualization and Processing of Higher Order
Descriptors for Multi-Valued Data, edited by Ingrid Hotz and Thomas Schultz,
1st ed., vol. 40, Springer, 2015, pp. 257–67, doi:10.1007/978-3-319-15090-1_13.
short: V. Zobel, J. Reininghaus, I. Hotz, in:, I. Hotz, T. Schultz (Eds.), Visualization
and Processing of Higher Order Descriptors for Multi-Valued Data, 1st ed., Springer,
2015, pp. 257–267.
date_created: 2018-12-11T11:52:33Z
date_published: 2015-01-01T00:00:00Z
date_updated: 2022-06-10T09:50:14Z
day: '01'
department:
- _id: HeEd
doi: 10.1007/978-3-319-15090-1_13
edition: '1'
editor:
- first_name: Ingrid
full_name: Hotz, Ingrid
last_name: Hotz
- first_name: Thomas
full_name: Schultz, Thomas
last_name: Schultz
intvolume: ' 40'
language:
- iso: eng
month: '01'
oa_version: None
page: 257 - 267
publication: Visualization and Processing of Higher Order Descriptors for Multi-Valued
Data
publication_identifier:
isbn:
- 978-3-319-15089-5
publication_status: published
publisher: Springer
publist_id: '5640'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Visualizing symmetric indefinite 2D tensor fields using The Heat Kernel Signature
type: book_chapter
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 40
year: '2015'
...
---
_id: '1530'
abstract:
- lang: eng
text: In growing cells, protein synthesis and cell growth are typically not synchronous,
and, thus, protein concentrations vary over the cell division cycle. We have developed
a theoretical description of genetic regulatory systems in bacteria that explicitly
considers the cell division cycle to investigate its impact on gene expression.
We calculate the cell-to-cell variations arising from cells being at different
stages in the division cycle for unregulated genes and for basic regulatory mechanisms.
These variations contribute to the extrinsic noise observed in single-cell experiments,
and are most significant for proteins with short lifetimes. Negative autoregulation
buffers against variation of protein concentration over the division cycle, but
the effect is found to be relatively weak. Stronger buffering is achieved by an
increased protein lifetime. Positive autoregulation can strongly amplify such
variation if the parameters are set to values that lead to resonance-like behaviour.
For cooperative positive autoregulation, the concentration variation over the
division cycle diminishes the parameter region of bistability and modulates the
switching times between the two stable states. The same effects are seen for a
two-gene mutual-repression toggle switch. By contrast, an oscillatory circuit,
the repressilator, is only weakly affected by the division cycle.
article_number: '066003'
author:
- first_name: Veronika
full_name: Bierbaum, Veronika
id: 3FD04378-F248-11E8-B48F-1D18A9856A87
last_name: Bierbaum
- first_name: Stefan
full_name: Klumpp, Stefan
last_name: Klumpp
citation:
ama: Bierbaum V, Klumpp S. Impact of the cell division cycle on gene circuits. Physical
Biology. 2015;12(6). doi:10.1088/1478-3975/12/6/066003
apa: Bierbaum, V., & Klumpp, S. (2015). Impact of the cell division cycle on
gene circuits. Physical Biology. IOP Publishing Ltd. https://doi.org/10.1088/1478-3975/12/6/066003
chicago: Bierbaum, Veronika, and Stefan Klumpp. “Impact of the Cell Division Cycle
on Gene Circuits.” Physical Biology. IOP Publishing Ltd., 2015. https://doi.org/10.1088/1478-3975/12/6/066003.
ieee: V. Bierbaum and S. Klumpp, “Impact of the cell division cycle on gene circuits,”
Physical Biology, vol. 12, no. 6. IOP Publishing Ltd., 2015.
ista: Bierbaum V, Klumpp S. 2015. Impact of the cell division cycle on gene circuits.
Physical Biology. 12(6), 066003.
mla: Bierbaum, Veronika, and Stefan Klumpp. “Impact of the Cell Division Cycle on
Gene Circuits.” Physical Biology, vol. 12, no. 6, 066003, IOP Publishing
Ltd., 2015, doi:10.1088/1478-3975/12/6/066003.
short: V. Bierbaum, S. Klumpp, Physical Biology 12 (2015).
date_created: 2018-12-11T11:52:33Z
date_published: 2015-09-25T00:00:00Z
date_updated: 2021-01-12T06:51:25Z
day: '25'
department:
- _id: MiSi
doi: 10.1088/1478-3975/12/6/066003
intvolume: ' 12'
issue: '6'
language:
- iso: eng
month: '09'
oa_version: None
publication: Physical Biology
publication_status: published
publisher: IOP Publishing Ltd.
publist_id: '5641'
quality_controlled: '1'
scopus_import: 1
status: public
title: Impact of the cell division cycle on gene circuits
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 12
year: '2015'
...
---
_id: '1539'
abstract:
- lang: eng
text: 'Many stochastic models of biochemical reaction networks contain some chemical
species for which the number of molecules that are present in the system can only
be finite (for instance due to conservation laws), but also other species that
can be present in arbitrarily large amounts. The prime example of such networks
are models of gene expression, which typically contain a small and finite number
of possible states for the promoter but an infinite number of possible states
for the amount of mRNA and protein. One of the main approaches to analyze such
models is through the use of equations for the time evolution of moments of the
chemical species. Recently, a new approach based on conditional moments of the
species with infinite state space given all the different possible states of the
finite species has been proposed. It was argued that this approach allows one
to capture more details about the full underlying probability distribution with
a smaller number of equations. Here, I show that the result that less moments
provide more information can only stem from an unnecessarily complicated description
of the system in the classical formulation. The foundation of this argument will
be the derivation of moment equations that describe the complete probability distribution
over the finite state space but only low-order moments over the infinite state
space. I will show that the number of equations that is needed is always less
than what was previously claimed and always less than the number of conditional
moment equations up to the same order. To support these arguments, a symbolic
algorithm is provided that can be used to derive minimal systems of unconditional
moment equations for models with partially finite state space. '
article_number: '244103'
author:
- first_name: Jakob
full_name: Ruess, Jakob
id: 4A245D00-F248-11E8-B48F-1D18A9856A87
last_name: Ruess
orcid: 0000-0003-1615-3282
citation:
ama: Ruess J. Minimal moment equations for stochastic models of biochemical reaction
networks with partially finite state space. Journal of Chemical Physics.
2015;143(24). doi:10.1063/1.4937937
apa: Ruess, J. (2015). Minimal moment equations for stochastic models of biochemical
reaction networks with partially finite state space. Journal of Chemical Physics.
American Institute of Physics. https://doi.org/10.1063/1.4937937
chicago: Ruess, Jakob. “Minimal Moment Equations for Stochastic Models of Biochemical
Reaction Networks with Partially Finite State Space.” Journal of Chemical Physics.
American Institute of Physics, 2015. https://doi.org/10.1063/1.4937937.
ieee: J. Ruess, “Minimal moment equations for stochastic models of biochemical reaction
networks with partially finite state space,” Journal of Chemical Physics,
vol. 143, no. 24. American Institute of Physics, 2015.
ista: Ruess J. 2015. Minimal moment equations for stochastic models of biochemical
reaction networks with partially finite state space. Journal of Chemical Physics.
143(24), 244103.
mla: Ruess, Jakob. “Minimal Moment Equations for Stochastic Models of Biochemical
Reaction Networks with Partially Finite State Space.” Journal of Chemical Physics,
vol. 143, no. 24, 244103, American Institute of Physics, 2015, doi:10.1063/1.4937937.
short: J. Ruess, Journal of Chemical Physics 143 (2015).
date_created: 2018-12-11T11:52:36Z
date_published: 2015-12-22T00:00:00Z
date_updated: 2021-01-12T06:51:28Z
day: '22'
ddc:
- '000'
department:
- _id: ToHe
- _id: GaTk
doi: 10.1063/1.4937937
ec_funded: 1
file:
- access_level: open_access
checksum: 838657118ae286463a2b7737319f35ce
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:07:43Z
date_updated: 2020-07-14T12:45:01Z
file_id: '4641'
file_name: IST-2016-593-v1+1_Minimal_moment_equations.pdf
file_size: 605355
relation: main_file
file_date_updated: 2020-07-14T12:45:01Z
has_accepted_license: '1'
intvolume: ' 143'
issue: '24'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
project:
- _id: 25EE3708-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '267989'
name: Quantitative Reactive Modeling
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S 11407_N23
name: Rigorous Systems Engineering
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z211
name: The Wittgenstein Prize
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication: Journal of Chemical Physics
publication_status: published
publisher: American Institute of Physics
publist_id: '5632'
pubrep_id: '593'
quality_controlled: '1'
scopus_import: 1
status: public
title: Minimal moment equations for stochastic models of biochemical reaction networks
with partially finite state space
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 143
year: '2015'
...
---
_id: '1534'
abstract:
- lang: eng
text: PIN proteins are auxin export carriers that direct intercellular auxin flow
and in turn regulate many aspects of plant growth and development including responses
to environmental changes. The Arabidopsis R2R3-MYB transcription factor FOUR LIPS
(FLP) and its paralogue MYB88 regulate terminal divisions during stomatal development,
as well as female reproductive development and stress responses. Here we show
that FLP and MYB88 act redundantly but differentially in regulating the transcription
of PIN3 and PIN7 in gravity-sensing cells of primary and lateral roots. On the
one hand, FLP is involved in responses to gravity stimulation in primary roots,
whereas on the other, FLP and MYB88 function complementarily in establishing the
gravitropic set-point angles of lateral roots. Our results support a model in
which FLP and MYB88 expression specifically determines the temporal-spatial patterns
of PIN3 and PIN7 transcription that are closely associated with their preferential
functions during root responses to gravity.
article_number: '8822'
author:
- first_name: Hongzhe
full_name: Wang, Hongzhe
last_name: Wang
- first_name: Kezhen
full_name: Yang, Kezhen
last_name: Yang
- first_name: Junjie
full_name: Zou, Junjie
last_name: Zou
- first_name: Lingling
full_name: Zhu, Lingling
last_name: Zhu
- first_name: Zidian
full_name: Xie, Zidian
last_name: Xie
- first_name: Miyoterao
full_name: Morita, Miyoterao
last_name: Morita
- first_name: Masao
full_name: Tasaka, Masao
last_name: Tasaka
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Erich
full_name: Grotewold, Erich
last_name: Grotewold
- first_name: Tom
full_name: Beeckman, Tom
last_name: Beeckman
- first_name: Steffen
full_name: Vanneste, Steffen
last_name: Vanneste
- first_name: Fred
full_name: Sack, Fred
last_name: Sack
- first_name: Jie
full_name: Le, Jie
last_name: Le
citation:
ama: Wang H, Yang K, Zou J, et al. Transcriptional regulation of PIN genes by FOUR
LIPS and MYB88 during Arabidopsis root gravitropism. Nature Communications.
2015;6. doi:10.1038/ncomms9822
apa: Wang, H., Yang, K., Zou, J., Zhu, L., Xie, Z., Morita, M., … Le, J. (2015).
Transcriptional regulation of PIN genes by FOUR LIPS and MYB88 during Arabidopsis
root gravitropism. Nature Communications. Nature Publishing Group. https://doi.org/10.1038/ncomms9822
chicago: Wang, Hongzhe, Kezhen Yang, Junjie Zou, Lingling Zhu, Zidian Xie, Miyoterao
Morita, Masao Tasaka, et al. “Transcriptional Regulation of PIN Genes by FOUR
LIPS and MYB88 during Arabidopsis Root Gravitropism.” Nature Communications.
Nature Publishing Group, 2015. https://doi.org/10.1038/ncomms9822.
ieee: H. Wang et al., “Transcriptional regulation of PIN genes by FOUR LIPS
and MYB88 during Arabidopsis root gravitropism,” Nature Communications,
vol. 6. Nature Publishing Group, 2015.
ista: Wang H, Yang K, Zou J, Zhu L, Xie Z, Morita M, Tasaka M, Friml J, Grotewold
E, Beeckman T, Vanneste S, Sack F, Le J. 2015. Transcriptional regulation of PIN
genes by FOUR LIPS and MYB88 during Arabidopsis root gravitropism. Nature Communications.
6, 8822.
mla: Wang, Hongzhe, et al. “Transcriptional Regulation of PIN Genes by FOUR LIPS
and MYB88 during Arabidopsis Root Gravitropism.” Nature Communications,
vol. 6, 8822, Nature Publishing Group, 2015, doi:10.1038/ncomms9822.
short: H. Wang, K. Yang, J. Zou, L. Zhu, Z. Xie, M. Morita, M. Tasaka, J. Friml,
E. Grotewold, T. Beeckman, S. Vanneste, F. Sack, J. Le, Nature Communications
6 (2015).
date_created: 2018-12-11T11:52:34Z
date_published: 2015-11-18T00:00:00Z
date_updated: 2021-01-12T06:51:26Z
day: '18'
ddc:
- '570'
department:
- _id: JiFr
doi: 10.1038/ncomms9822
ec_funded: 1
file:
- access_level: open_access
checksum: 3c06735fc7cd7e482ca830cbd26001bf
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:17:07Z
date_updated: 2020-07-14T12:45:01Z
file_id: '5259'
file_name: IST-2016-485-v1+1_ncomms9822.pdf
file_size: 1852268
relation: main_file
file_date_updated: 2020-07-14T12:45:01Z
has_accepted_license: '1'
intvolume: ' 6'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
project:
- _id: 25716A02-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '282300'
name: Polarity and subcellular dynamics in plants
publication: Nature Communications
publication_status: published
publisher: Nature Publishing Group
publist_id: '5637'
pubrep_id: '485'
quality_controlled: '1'
scopus_import: 1
status: public
title: Transcriptional regulation of PIN genes by FOUR LIPS and MYB88 during Arabidopsis
root gravitropism
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 6
year: '2015'
...
---
_id: '1538'
abstract:
- lang: eng
text: Systems biology rests on the idea that biological complexity can be better
unraveled through the interplay of modeling and experimentation. However, the
success of this approach depends critically on the informativeness of the chosen
experiments, which is usually unknown a priori. Here, we propose a systematic
scheme based on iterations of optimal experiment design, flow cytometry experiments,
and Bayesian parameter inference to guide the discovery process in the case of
stochastic biochemical reaction networks. To illustrate the benefit of our methodology,
we apply it to the characterization of an engineered light-inducible gene expression
circuit in yeast and compare the performance of the resulting model with models
identified from nonoptimal experiments. In particular, we compare the parameter
posterior distributions and the precision to which the outcome of future experiments
can be predicted. Moreover, we illustrate how the identified stochastic model
can be used to determine light induction patterns that make either the average
amount of protein or the variability in a population of cells follow a desired
profile. Our results show that optimal experiment design allows one to derive
models that are accurate enough to precisely predict and regulate the protein
expression in heterogeneous cell populations over extended periods of time.
acknowledgement: 'J.R., F.P., and J.L. acknowledge support from the European Commission
under the Network of Excellence HYCON2 (highly-complex and networked control systems)
and SystemsX.ch under the SignalX Project. J.R. acknowledges support from the People
Programme (Marie Curie Actions) of the European Union’s Seventh Framework Programme
FP7/2007-2013 under REA (Research Executive Agency) Grant 291734. M.K. acknowledges
support from Human Frontier Science Program Grant RP0061/2011 (www.hfsp.org). '
author:
- first_name: Jakob
full_name: Ruess, Jakob
id: 4A245D00-F248-11E8-B48F-1D18A9856A87
last_name: Ruess
orcid: 0000-0003-1615-3282
- first_name: Francesca
full_name: Parise, Francesca
last_name: Parise
- first_name: Andreas
full_name: Milias Argeitis, Andreas
last_name: Milias Argeitis
- first_name: Mustafa
full_name: Khammash, Mustafa
last_name: Khammash
- first_name: John
full_name: Lygeros, John
last_name: Lygeros
citation:
ama: Ruess J, Parise F, Milias Argeitis A, Khammash M, Lygeros J. Iterative experiment
design guides the characterization of a light-inducible gene expression circuit.
PNAS. 2015;112(26):8148-8153. doi:10.1073/pnas.1423947112
apa: Ruess, J., Parise, F., Milias Argeitis, A., Khammash, M., & Lygeros, J.
(2015). Iterative experiment design guides the characterization of a light-inducible
gene expression circuit. PNAS. National Academy of Sciences. https://doi.org/10.1073/pnas.1423947112
chicago: Ruess, Jakob, Francesca Parise, Andreas Milias Argeitis, Mustafa Khammash,
and John Lygeros. “Iterative Experiment Design Guides the Characterization of
a Light-Inducible Gene Expression Circuit.” PNAS. National Academy of Sciences,
2015. https://doi.org/10.1073/pnas.1423947112.
ieee: J. Ruess, F. Parise, A. Milias Argeitis, M. Khammash, and J. Lygeros, “Iterative
experiment design guides the characterization of a light-inducible gene expression
circuit,” PNAS, vol. 112, no. 26. National Academy of Sciences, pp. 8148–8153,
2015.
ista: Ruess J, Parise F, Milias Argeitis A, Khammash M, Lygeros J. 2015. Iterative
experiment design guides the characterization of a light-inducible gene expression
circuit. PNAS. 112(26), 8148–8153.
mla: Ruess, Jakob, et al. “Iterative Experiment Design Guides the Characterization
of a Light-Inducible Gene Expression Circuit.” PNAS, vol. 112, no. 26,
National Academy of Sciences, 2015, pp. 8148–53, doi:10.1073/pnas.1423947112.
short: J. Ruess, F. Parise, A. Milias Argeitis, M. Khammash, J. Lygeros, PNAS 112
(2015) 8148–8153.
date_created: 2018-12-11T11:52:36Z
date_published: 2015-06-30T00:00:00Z
date_updated: 2021-01-12T06:51:27Z
day: '30'
department:
- _id: ToHe
- _id: GaTk
doi: 10.1073/pnas.1423947112
ec_funded: 1
external_id:
pmid:
- '26085136'
intvolume: ' 112'
issue: '26'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491780/
month: '06'
oa: 1
oa_version: Submitted Version
page: 8148 - 8153
pmid: 1
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication: PNAS
publication_status: published
publisher: National Academy of Sciences
publist_id: '5633'
quality_controlled: '1'
scopus_import: 1
status: public
title: Iterative experiment design guides the characterization of a light-inducible
gene expression circuit
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 112
year: '2015'
...
---
_id: '1535'
abstract:
- lang: eng
text: Neuronal and neuroendocrine L-type calcium channels (Cav1.2, Cav1.3) open
readily at relatively low membrane potentials and allow Ca2+ to enter the cells
near resting potentials. In this way, Cav1.2 and Cav1.3 shape the action potential
waveform, contribute to gene expression, synaptic plasticity, neuronal differentiation,
hormone secretion and pacemaker activity. In the chromaffin cells (CCs) of the
adrenal medulla, Cav1.3 is highly expressed and is shown to support most of the
pacemaking current that sustains action potential (AP) firings and part of the
catecholamine secretion. Cav1.3 forms Ca2+-nanodomains with the fast inactivating
BK channels and drives the resting SK currents. These latter set the inter-spike
interval duration between consecutive spikes during spontaneous firing and the
rate of spike adaptation during sustained depolarizations. Cav1.3 plays also a
primary role in the switch from “tonic” to “burst” firing that occurs in mouse
CCs when either the availability of voltage-gated Na channels (Nav) is reduced
or the β2 subunit featuring the fast inactivating BK channels is deleted. Here,
we discuss the functional role of these “neuronlike” firing modes in CCs and how
Cav1.3 contributes to them. The open issue is to understand how these novel firing
patterns are adapted to regulate the quantity of circulating catecholamines during
resting condition or in response to acute and chronic stress.
acknowledgement: This work was supported by the Italian MIUR (PRIN 2010/2011 project
2010JFYFY2) and the University of Torino.
article_processing_charge: No
article_type: original
author:
- first_name: David H
full_name: Vandael, David H
id: 3AE48E0A-F248-11E8-B48F-1D18A9856A87
last_name: Vandael
orcid: 0000-0001-7577-1676
- first_name: Andrea
full_name: Marcantoni, Andrea
last_name: Marcantoni
- first_name: Emilio
full_name: Carbone, Emilio
last_name: Carbone
citation:
ama: Vandael DH, Marcantoni A, Carbone E. Cav1.3 channels as key regulators of neuron-like
firings and catecholamine release in chromaffin cells. Current Molecular Pharmacology.
2015;8(2):149-161. doi:10.2174/1874467208666150507105443
apa: Vandael, D. H., Marcantoni, A., & Carbone, E. (2015). Cav1.3 channels as
key regulators of neuron-like firings and catecholamine release in chromaffin
cells. Current Molecular Pharmacology. Bentham Science Publishers. https://doi.org/10.2174/1874467208666150507105443
chicago: Vandael, David H, Andrea Marcantoni, and Emilio Carbone. “Cav1.3 Channels
as Key Regulators of Neuron-like Firings and Catecholamine Release in Chromaffin
Cells.” Current Molecular Pharmacology. Bentham Science Publishers, 2015.
https://doi.org/10.2174/1874467208666150507105443.
ieee: D. H. Vandael, A. Marcantoni, and E. Carbone, “Cav1.3 channels as key regulators
of neuron-like firings and catecholamine release in chromaffin cells,” Current
Molecular Pharmacology, vol. 8, no. 2. Bentham Science Publishers, pp. 149–161,
2015.
ista: Vandael DH, Marcantoni A, Carbone E. 2015. Cav1.3 channels as key regulators
of neuron-like firings and catecholamine release in chromaffin cells. Current
Molecular Pharmacology. 8(2), 149–161.
mla: Vandael, David H., et al. “Cav1.3 Channels as Key Regulators of Neuron-like
Firings and Catecholamine Release in Chromaffin Cells.” Current Molecular Pharmacology,
vol. 8, no. 2, Bentham Science Publishers, 2015, pp. 149–61, doi:10.2174/1874467208666150507105443.
short: D.H. Vandael, A. Marcantoni, E. Carbone, Current Molecular Pharmacology 8
(2015) 149–161.
date_created: 2018-12-11T11:52:35Z
date_published: 2015-10-01T00:00:00Z
date_updated: 2021-01-12T06:51:26Z
day: '01'
department:
- _id: PeJo
doi: 10.2174/1874467208666150507105443
external_id:
pmid:
- '25966692'
intvolume: ' 8'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384372/
month: '10'
oa: 1
oa_version: Submitted Version
page: 149 - 161
pmid: 1
publication: Current Molecular Pharmacology
publication_status: published
publisher: Bentham Science Publishers
publist_id: '5636'
quality_controlled: '1'
scopus_import: 1
status: public
title: Cav1.3 channels as key regulators of neuron-like firings and catecholamine
release in chromaffin cells
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 8
year: '2015'
...
---
_id: '1536'
abstract:
- lang: eng
text: Strigolactones, first discovered as germination stimulants for parasitic weeds
[1], are carotenoid-derived phytohormones that play major roles in inhibiting
lateral bud outgrowth and promoting plant-mycorrhizal symbiosis [2-4]. Furthermore,
strigolactones are involved in the regulation of lateral and adventitious root
development, root cell division [5, 6], secondary growth [7], and leaf senescence
[8]. Recently, we discovered the strigolactone transporter Petunia axillaris PLEIOTROPIC
DRUG RESISTANCE 1 (PaPDR1), which is required for efficient mycorrhizal colonization
and inhibition of lateral bud outgrowth [9]. However, how strigolactones are transported
through the plant remained unknown. Here we show that PaPDR1 exhibits a cell-type-specific
asymmetric localization in different root tissues. In root tips, PaPDR1 is co-expressed
with the strigolactone biosynthetic gene DAD1 (CCD8), and it is localized at the
apical membrane of root hypodermal cells, presumably mediating the shootward transport
of strigolactone. Above the root tip, in the hypodermal passage cells that form
gates for the entry of mycorrhizal fungi, PaPDR1 is present in the outer-lateral
membrane, compatible with its postulated function as strigolactone exporter from
root to soil. Transport studies are in line with our localization studies since
(1) a papdr1 mutant displays impaired transport of strigolactones out of the root
tip to the shoot as well as into the rhizosphere and (2) DAD1 expression and PIN1/PIN2
levels change in plants deregulated for PDR1 expression, suggestive of variations
in endogenous strigolactone contents. In conclusion, our results indicate that
the polar localizations of PaPDR1 mediate directional shootward strigolactone
transport as well as localized exudation into the soil.
acknowledgement: "This work was funded by a grant of the Swiss National Foundation
to E.M.\r\nWe thank Dr. José María Mateos (University of Zurich) for providing us
with the vibratome, Prof. Dolf Weijers (Wageningen University, the Netherlands)
for shipping us his set of ligation-independent cloning vectors, Prof. Bruno Humbel
(University of Lausanne) for suggestions on GFP-PDR1 detection, and Dr. Undine Krügel
(University of Zurich) and Prof. Michal Jasinski (Polish Academy of Science) for
hints on protein quantification."
author:
- first_name: Joëlle
full_name: Sasse, Joëlle
last_name: Sasse
- first_name: Sibu
full_name: Simon, Sibu
id: 4542EF9A-F248-11E8-B48F-1D18A9856A87
last_name: Simon
orcid: 0000-0002-1998-6741
- first_name: Christian
full_name: Gübeli, Christian
last_name: Gübeli
- first_name: Guowei
full_name: Liu, Guowei
last_name: Liu
- first_name: Xi
full_name: Cheng, Xi
last_name: Cheng
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Harro
full_name: Bouwmeester, Harro
last_name: Bouwmeester
- first_name: Enrico
full_name: Martinoia, Enrico
last_name: Martinoia
- first_name: Lorenzo
full_name: Borghi, Lorenzo
last_name: Borghi
citation:
ama: Sasse J, Simon S, Gübeli C, et al. Asymmetric localizations of the ABC transporter
PaPDR1 trace paths of directional strigolactone transport. Current Biology.
2015;25(5):647-655. doi:10.1016/j.cub.2015.01.015
apa: Sasse, J., Simon, S., Gübeli, C., Liu, G., Cheng, X., Friml, J., … Borghi,
L. (2015). Asymmetric localizations of the ABC transporter PaPDR1 trace paths
of directional strigolactone transport. Current Biology. Cell Press. https://doi.org/10.1016/j.cub.2015.01.015
chicago: Sasse, Joëlle, Sibu Simon, Christian Gübeli, Guowei Liu, Xi Cheng, Jiří
Friml, Harro Bouwmeester, Enrico Martinoia, and Lorenzo Borghi. “Asymmetric Localizations
of the ABC Transporter PaPDR1 Trace Paths of Directional Strigolactone Transport.”
Current Biology. Cell Press, 2015. https://doi.org/10.1016/j.cub.2015.01.015.
ieee: J. Sasse et al., “Asymmetric localizations of the ABC transporter PaPDR1
trace paths of directional strigolactone transport,” Current Biology, vol.
25, no. 5. Cell Press, pp. 647–655, 2015.
ista: Sasse J, Simon S, Gübeli C, Liu G, Cheng X, Friml J, Bouwmeester H, Martinoia
E, Borghi L. 2015. Asymmetric localizations of the ABC transporter PaPDR1 trace
paths of directional strigolactone transport. Current Biology. 25(5), 647–655.
mla: Sasse, Joëlle, et al. “Asymmetric Localizations of the ABC Transporter PaPDR1
Trace Paths of Directional Strigolactone Transport.” Current Biology, vol.
25, no. 5, Cell Press, 2015, pp. 647–55, doi:10.1016/j.cub.2015.01.015.
short: J. Sasse, S. Simon, C. Gübeli, G. Liu, X. Cheng, J. Friml, H. Bouwmeester,
E. Martinoia, L. Borghi, Current Biology 25 (2015) 647–655.
date_created: 2018-12-11T11:52:35Z
date_published: 2015-02-12T00:00:00Z
date_updated: 2021-01-12T06:51:27Z
day: '12'
department:
- _id: JiFr
doi: 10.1016/j.cub.2015.01.015
intvolume: ' 25'
issue: '5'
language:
- iso: eng
month: '02'
oa_version: None
page: 647 - 655
publication: Current Biology
publication_status: published
publisher: Cell Press
publist_id: '5635'
quality_controlled: '1'
scopus_import: 1
status: public
title: Asymmetric localizations of the ABC transporter PaPDR1 trace paths of directional
strigolactone transport
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 25
year: '2015'
...
---
_id: '1533'
abstract:
- lang: eng
text: This paper addresses the problem of semantic segmentation, where the possible
class labels are from a predefined set. We exploit top-down guidance, i.e., the
coarse localization of the objects and their class labels provided by object detectors.
For each detected bounding box, figure-ground segmentation is performed and the
final result is achieved by merging the figure-ground segmentations. The main
idea of the proposed approach, which is presented in our preliminary work, is
to reformulate the figure-ground segmentation problem as sparse reconstruction
pursuing the object mask in a nonparametric manner. The latent segmentation mask
should be coherent subject to sparse error caused by intra-category diversity;
thus, the object mask is inferred by making use of sparse representations over
the training set. To handle local spatial deformations, local patch-level masks
are also considered and inferred by sparse representations over the spatially
nearby patches. The sparse reconstruction coefficients and the latent mask are
alternately optimized by applying the Lasso algorithm and the accelerated proximal
gradient method. The proposed formulation results in a convex optimization problem;
thus, the global optimal solution is achieved. In this paper, we provide theoretical
analysis of the convergence and optimality. We also give an extended numerical
analysis of the proposed algorithm and a comprehensive comparison with the related
semantic segmentation methods on the challenging PASCAL visual object class object
segmentation datasets and the Weizmann horse dataset. The experimental results
demonstrate that the proposed algorithm achieves a competitive performance when
compared with the state of the arts.
author:
- first_name: Wei
full_name: Xia, Wei
last_name: Xia
- first_name: Csaba
full_name: Domokos, Csaba
id: 492DACF8-F248-11E8-B48F-1D18A9856A87
last_name: Domokos
- first_name: Junjun
full_name: Xiong, Junjun
last_name: Xiong
- first_name: Loongfah
full_name: Cheong, Loongfah
last_name: Cheong
- first_name: Shuicheng
full_name: Yan, Shuicheng
last_name: Yan
citation:
ama: Xia W, Domokos C, Xiong J, Cheong L, Yan S. Segmentation over detection via
optimal sparse reconstructions. IEEE Transactions on Circuits and Systems for
Video Technology. 2015;25(8):1295-1308. doi:10.1109/TCSVT.2014.2379972
apa: Xia, W., Domokos, C., Xiong, J., Cheong, L., & Yan, S. (2015). Segmentation
over detection via optimal sparse reconstructions. IEEE Transactions on Circuits
and Systems for Video Technology. IEEE. https://doi.org/10.1109/TCSVT.2014.2379972
chicago: Xia, Wei, Csaba Domokos, Junjun Xiong, Loongfah Cheong, and Shuicheng Yan.
“Segmentation over Detection via Optimal Sparse Reconstructions.” IEEE Transactions
on Circuits and Systems for Video Technology. IEEE, 2015. https://doi.org/10.1109/TCSVT.2014.2379972.
ieee: W. Xia, C. Domokos, J. Xiong, L. Cheong, and S. Yan, “Segmentation over detection
via optimal sparse reconstructions,” IEEE Transactions on Circuits and Systems
for Video Technology, vol. 25, no. 8. IEEE, pp. 1295–1308, 2015.
ista: Xia W, Domokos C, Xiong J, Cheong L, Yan S. 2015. Segmentation over detection
via optimal sparse reconstructions. IEEE Transactions on Circuits and Systems
for Video Technology. 25(8), 1295–1308.
mla: Xia, Wei, et al. “Segmentation over Detection via Optimal Sparse Reconstructions.”
IEEE Transactions on Circuits and Systems for Video Technology, vol. 25,
no. 8, IEEE, 2015, pp. 1295–308, doi:10.1109/TCSVT.2014.2379972.
short: W. Xia, C. Domokos, J. Xiong, L. Cheong, S. Yan, IEEE Transactions on Circuits
and Systems for Video Technology 25 (2015) 1295–1308.
date_created: 2018-12-11T11:52:34Z
date_published: 2015-08-01T00:00:00Z
date_updated: 2021-01-12T06:51:26Z
day: '01'
department:
- _id: ChLa
doi: 10.1109/TCSVT.2014.2379972
intvolume: ' 25'
issue: '8'
language:
- iso: eng
month: '08'
oa_version: None
page: 1295 - 1308
publication: IEEE Transactions on Circuits and Systems for Video Technology
publication_status: published
publisher: IEEE
publist_id: '5638'
quality_controlled: '1'
scopus_import: 1
status: public
title: Segmentation over detection via optimal sparse reconstructions
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 25
year: '2015'
...
---
_id: '1542'
abstract:
- lang: eng
text: 'The theory of population genetics and evolutionary computation have been
evolving separately for nearly 30 years. Many results have been independently
obtained in both fields and many others are unique to its respective field. We
aim to bridge this gap by developing a unifying framework for evolutionary processes
that allows both evolutionary algorithms and population genetics models to be
cast in the same formal framework. The framework we present here decomposes the
evolutionary process into its several components in order to facilitate the identification
of similarities between different models. In particular, we propose a classification
of evolutionary operators based on the defining properties of the different components.
We cast several commonly used operators from both fields into this common framework.
Using this, we map different evolutionary and genetic algorithms to different
evolutionary regimes and identify candidates with the most potential for the translation
of results between the fields. This provides a unified description of evolutionary
processes and represents a stepping stone towards new tools and results to both
fields. '
author:
- first_name: Tiago
full_name: Paixao, Tiago
id: 2C5658E6-F248-11E8-B48F-1D18A9856A87
last_name: Paixao
orcid: 0000-0003-2361-3953
- first_name: Golnaz
full_name: Badkobeh, Golnaz
last_name: Badkobeh
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Doğan
full_name: Çörüş, Doğan
last_name: Çörüş
- first_name: Duccuong
full_name: Dang, Duccuong
last_name: Dang
- first_name: Tobias
full_name: Friedrich, Tobias
last_name: Friedrich
- first_name: Per
full_name: Lehre, Per
last_name: Lehre
- first_name: Dirk
full_name: Sudholt, Dirk
last_name: Sudholt
- first_name: Andrew
full_name: Sutton, Andrew
last_name: Sutton
- first_name: Barbora
full_name: Trubenova, Barbora
id: 42302D54-F248-11E8-B48F-1D18A9856A87
last_name: Trubenova
orcid: 0000-0002-6873-2967
citation:
ama: Paixao T, Badkobeh G, Barton NH, et al. Toward a unifying framework for evolutionary
processes. Journal of Theoretical Biology. 2015;383:28-43. doi:10.1016/j.jtbi.2015.07.011
apa: Paixao, T., Badkobeh, G., Barton, N. H., Çörüş, D., Dang, D., Friedrich, T.,
… Trubenova, B. (2015). Toward a unifying framework for evolutionary processes.
Journal of Theoretical Biology. Elsevier. https://doi.org/10.1016/j.jtbi.2015.07.011
chicago: Paixao, Tiago, Golnaz Badkobeh, Nicholas H Barton, Doğan Çörüş, Duccuong
Dang, Tobias Friedrich, Per Lehre, Dirk Sudholt, Andrew Sutton, and Barbora Trubenova.
“Toward a Unifying Framework for Evolutionary Processes.” Journal of Theoretical
Biology. Elsevier, 2015. https://doi.org/10.1016/j.jtbi.2015.07.011.
ieee: T. Paixao et al., “Toward a unifying framework for evolutionary processes,”
Journal of Theoretical Biology, vol. 383. Elsevier, pp. 28–43, 2015.
ista: Paixao T, Badkobeh G, Barton NH, Çörüş D, Dang D, Friedrich T, Lehre P, Sudholt
D, Sutton A, Trubenova B. 2015. Toward a unifying framework for evolutionary processes. Journal
of Theoretical Biology. 383, 28–43.
mla: Paixao, Tiago, et al. “Toward a Unifying Framework for Evolutionary Processes.”
Journal of Theoretical Biology, vol. 383, Elsevier, 2015, pp. 28–43, doi:10.1016/j.jtbi.2015.07.011.
short: T. Paixao, G. Badkobeh, N.H. Barton, D. Çörüş, D. Dang, T. Friedrich, P.
Lehre, D. Sudholt, A. Sutton, B. Trubenova, Journal of Theoretical Biology 383
(2015) 28–43.
date_created: 2018-12-11T11:52:37Z
date_published: 2015-10-21T00:00:00Z
date_updated: 2021-01-12T06:51:29Z
day: '21'
ddc:
- '570'
department:
- _id: NiBa
- _id: CaGu
doi: 10.1016/j.jtbi.2015.07.011
ec_funded: 1
file:
- access_level: open_access
checksum: 33b60ecfea60764756a9ee9df5eb65ca
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:16:53Z
date_updated: 2020-07-14T12:45:01Z
file_id: '5244'
file_name: IST-2016-483-v1+1_1-s2.0-S0022519315003409-main.pdf
file_size: 595307
relation: main_file
file_date_updated: 2020-07-14T12:45:01Z
has_accepted_license: '1'
intvolume: ' 383'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '10'
oa: 1
oa_version: Published Version
page: 28 - 43
project:
- _id: 25B1EC9E-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '618091'
name: Speed of Adaptation in Population Genetics and Evolutionary Computation
- _id: 25B07788-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '250152'
name: Limits to selection in biology and in evolutionary computation
publication: ' Journal of Theoretical Biology'
publication_status: published
publisher: Elsevier
publist_id: '5629'
pubrep_id: '483'
quality_controlled: '1'
scopus_import: 1
status: public
title: Toward a unifying framework for evolutionary processes
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 383
year: '2015'
...
---
_id: '1546'
abstract:
- lang: eng
text: Synaptic efficacy and precision are influenced by the coupling of voltage-gated
Ca2+ channels (VGCCs) to vesicles. But because the topography of VGCCs and their
proximity to vesicles is unknown, a quantitative understanding of the determinants
of vesicular release at nanometer scale is lacking. To investigate this, we combined
freeze-fracture replica immunogold labeling of Cav2.1 channels, local [Ca2+] imaging,
and patch pipette perfusion of EGTA at the calyx of Held. Between postnatal day
7 and 21, VGCCs formed variable sized clusters and vesicular release became less
sensitive to EGTA, whereas fixed Ca2+ buffer properties remained constant. Experimentally
constrained reaction-diffusion simulations suggest that Ca2+ sensors for vesicular
release are located at the perimeter of VGCC clusters (<30nm) and predict that
VGCC number per cluster determines vesicular release probability without altering
release time course. This "perimeter release model" provides a unifying
framework accounting for developmental changes in both synaptic efficacy and time
course.
acknowledgement: This work was supported by the Core Research for Evolutional Science
and Technology (CREST) of Japan Science and Technology Agency to T.T. and R.S.;
by the funding provided by Okinawa Institute of Science and Technology (OIST) to
T.T. and Y.N.; by JSPS Core-to-Core Program, A. Advanced Networks to T.T.; by the
Grant-in-Aid for Young Scientists from the Japanese Ministry of Education, Culture,
Sports, Science and Technology (#23700474) to Y.N.; by the Centre National de la
Recherche Scientifique through the Actions Thematiques et Initatives sur Programme,
Fondation Fyssen, Fondation pour la Recherche Medicale, Federation pour la Recherche
sur le Cerveau, Agence Nationale de la Recherche (ANR-2007-Neuro-008-01 and ANR-2010-BLAN-1411-01)
to D.D. and Y.N.; and by the European Commission Coordination Action ENINET (LSHM-CT-2005-19063)
to D.D. and R.A.S. R.A.S. and J.S.R. were funded by Wellcome Trust Senior (064413)
and Principal (095667) Research Fellowship and an ERC advance grant (294667) to
RAS.
author:
- first_name: Yukihiro
full_name: Nakamura, Yukihiro
last_name: Nakamura
- first_name: Harumi
full_name: Harada, Harumi
id: 2E55CDF2-F248-11E8-B48F-1D18A9856A87
last_name: Harada
orcid: 0000-0001-7429-7896
- first_name: Naomi
full_name: Kamasawa, Naomi
last_name: Kamasawa
- first_name: Ko
full_name: Matsui, Ko
last_name: Matsui
- first_name: Jason
full_name: Rothman, Jason
last_name: Rothman
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: R Angus
full_name: Silver, R Angus
last_name: Silver
- first_name: David
full_name: Digregorio, David
last_name: Digregorio
- first_name: Tomoyuki
full_name: Takahashi, Tomoyuki
last_name: Takahashi
citation:
ama: Nakamura Y, Harada H, Kamasawa N, et al. Nanoscale distribution of presynaptic
Ca2+ channels and its impact on vesicular release during development. Neuron.
2015;85(1):145-158. doi:10.1016/j.neuron.2014.11.019
apa: Nakamura, Y., Harada, H., Kamasawa, N., Matsui, K., Rothman, J., Shigemoto,
R., … Takahashi, T. (2015). Nanoscale distribution of presynaptic Ca2+ channels
and its impact on vesicular release during development. Neuron. Elsevier.
https://doi.org/10.1016/j.neuron.2014.11.019
chicago: Nakamura, Yukihiro, Harumi Harada, Naomi Kamasawa, Ko Matsui, Jason Rothman,
Ryuichi Shigemoto, R Angus Silver, David Digregorio, and Tomoyuki Takahashi. “Nanoscale
Distribution of Presynaptic Ca2+ Channels and Its Impact on Vesicular Release
during Development.” Neuron. Elsevier, 2015. https://doi.org/10.1016/j.neuron.2014.11.019.
ieee: Y. Nakamura et al., “Nanoscale distribution of presynaptic Ca2+ channels
and its impact on vesicular release during development,” Neuron, vol. 85,
no. 1. Elsevier, pp. 145–158, 2015.
ista: Nakamura Y, Harada H, Kamasawa N, Matsui K, Rothman J, Shigemoto R, Silver
RA, Digregorio D, Takahashi T. 2015. Nanoscale distribution of presynaptic Ca2+
channels and its impact on vesicular release during development. Neuron. 85(1),
145–158.
mla: Nakamura, Yukihiro, et al. “Nanoscale Distribution of Presynaptic Ca2+ Channels
and Its Impact on Vesicular Release during Development.” Neuron, vol. 85,
no. 1, Elsevier, 2015, pp. 145–58, doi:10.1016/j.neuron.2014.11.019.
short: Y. Nakamura, H. Harada, N. Kamasawa, K. Matsui, J. Rothman, R. Shigemoto,
R.A. Silver, D. Digregorio, T. Takahashi, Neuron 85 (2015) 145–158.
date_created: 2018-12-11T11:52:39Z
date_published: 2015-01-07T00:00:00Z
date_updated: 2021-01-12T06:51:31Z
day: '07'
ddc:
- '570'
department:
- _id: RySh
doi: 10.1016/j.neuron.2014.11.019
file:
- access_level: open_access
checksum: 725f4d5be2dbb44b283ce722645ef37d
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:15:47Z
date_updated: 2020-07-14T12:45:01Z
file_id: '5170'
file_name: IST-2016-482-v1+1_1-s2.0-S0896627314010472-main.pdf
file_size: 3080111
relation: main_file
file_date_updated: 2020-07-14T12:45:01Z
has_accepted_license: '1'
intvolume: ' 85'
issue: '1'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
page: 145 - 158
publication: Neuron
publication_status: published
publisher: Elsevier
publist_id: '5625'
pubrep_id: '482'
quality_controlled: '1'
scopus_import: 1
status: public
title: Nanoscale distribution of presynaptic Ca2+ channels and its impact on vesicular
release during development
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 85
year: '2015'
...
---
_id: '1541'
abstract:
- lang: eng
text: We present XSpeed a parallel state-space exploration algorithm for continuous
systems with linear dynamics and nondeterministic inputs. The motivation of having
parallel algorithms is to exploit the computational power of multi-core processors
to speed-up performance. The parallelization is achieved on two fronts. First,
we propose a parallel implementation of the support function algorithm by sampling
functions in parallel. Second, we propose a parallel state-space exploration by
slicing the time horizon and computing the reachable states in the time slices
in parallel. The second method can be however applied only to a class of linear
systems with invertible dynamics and fixed input. A GP-GPU implementation is also
presented following a lazy evaluation strategy on support functions. The parallel
algorithms are implemented in the tool XSpeed. We evaluated the performance on
two benchmarks including an 28 dimension Helicopter model. Comparison with the
sequential counterpart shows a maximum speed-up of almost 7× on a 6 core, 12 thread
Intel Xeon CPU E5-2420 processor. Our GP-GPU implementation shows a maximum speed-up
of 12× over the sequential implementation and 53× over SpaceEx (LGG scenario),
the state of the art tool for reachability analysis of linear hybrid systems.
Experiments illustrate that our parallel algorithm with time slicing not only
speeds-up performance but also improves precision.
acknowledgement: This work was supported in part by the European Research Council
(ERC) under grant 267989 (QUAREM) and by the Austrian Science Fund (FWF) under grants
S11402-N23, S11405-N23 and S11412-N23 (RiSE/SHiNE) and Z211-N23 (Wittgenstein Award).
alternative_title:
- LNCS
author:
- first_name: Rajarshi
full_name: Ray, Rajarshi
last_name: Ray
- first_name: Amit
full_name: Gurung, Amit
last_name: Gurung
- first_name: Binayak
full_name: Das, Binayak
last_name: Das
- first_name: Ezio
full_name: Bartocci, Ezio
last_name: Bartocci
- first_name: Sergiy
full_name: Bogomolov, Sergiy
id: 369D9A44-F248-11E8-B48F-1D18A9856A87
last_name: Bogomolov
orcid: 0000-0002-0686-0365
- first_name: Radu
full_name: Grosu, Radu
last_name: Grosu
citation:
ama: 'Ray R, Gurung A, Das B, Bartocci E, Bogomolov S, Grosu R. XSpeed: Accelerating
reachability analysis on multi-core processors. 2015;9434:3-18. doi:10.1007/978-3-319-26287-1_1'
apa: 'Ray, R., Gurung, A., Das, B., Bartocci, E., Bogomolov, S., & Grosu, R.
(2015). XSpeed: Accelerating reachability analysis on multi-core processors. Presented
at the HVC: Haifa Verification Conference, Haifa, Israel: Springer. https://doi.org/10.1007/978-3-319-26287-1_1'
chicago: 'Ray, Rajarshi, Amit Gurung, Binayak Das, Ezio Bartocci, Sergiy Bogomolov,
and Radu Grosu. “XSpeed: Accelerating Reachability Analysis on Multi-Core Processors.”
Lecture Notes in Computer Science. Springer, 2015. https://doi.org/10.1007/978-3-319-26287-1_1.'
ieee: 'R. Ray, A. Gurung, B. Das, E. Bartocci, S. Bogomolov, and R. Grosu, “XSpeed:
Accelerating reachability analysis on multi-core processors,” vol. 9434. Springer,
pp. 3–18, 2015.'
ista: 'Ray R, Gurung A, Das B, Bartocci E, Bogomolov S, Grosu R. 2015. XSpeed: Accelerating
reachability analysis on multi-core processors. 9434, 3–18.'
mla: 'Ray, Rajarshi, et al. XSpeed: Accelerating Reachability Analysis on Multi-Core
Processors. Vol. 9434, Springer, 2015, pp. 3–18, doi:10.1007/978-3-319-26287-1_1.'
short: R. Ray, A. Gurung, B. Das, E. Bartocci, S. Bogomolov, R. Grosu, 9434 (2015)
3–18.
conference:
end_date: 2015-11-19
location: Haifa, Israel
name: 'HVC: Haifa Verification Conference'
start_date: 2015-11-17
date_created: 2018-12-11T11:52:37Z
date_published: 2015-11-28T00:00:00Z
date_updated: 2020-08-11T10:09:17Z
day: '28'
department:
- _id: ToHe
doi: 10.1007/978-3-319-26287-1_1
ec_funded: 1
intvolume: ' 9434'
language:
- iso: eng
month: '11'
oa_version: None
page: 3 - 18
project:
- _id: 25EE3708-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '267989'
name: Quantitative Reactive Modeling
- _id: 25F5A88A-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S11402-N23
name: Moderne Concurrency Paradigms
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S 11407_N23
name: Rigorous Systems Engineering
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z211
name: The Wittgenstein Prize
publication_status: published
publisher: Springer
publist_id: '5630'
quality_controlled: '1'
scopus_import: 1
series_title: Lecture Notes in Computer Science
status: public
title: 'XSpeed: Accelerating reachability analysis on multi-core processors'
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 9434
year: '2015'
...
---
_id: '1543'
abstract:
- lang: eng
text: A plethora of diverse programmed cell death (PCD) processes has been described
in living organisms. In animals and plants, different forms of PCD play crucial
roles in development, immunity, and responses to the environment. While the molecular
control of some animal PCD forms such as apoptosis is known in great detail, we
still know comparatively little about the regulation of the diverse types of plant
PCD. In part, this deficiency in molecular understanding is caused by the lack
of reliable reporters to detect PCD processes. Here, we addressed this issue by
using a combination of bioinformatics approaches to identify commonly regulated
genes during diverse plant PCD processes in Arabidopsis (Arabidopsis thaliana).
Our results indicate that the transcriptional signatures of developmentally controlled
cell death are largely distinct from the ones associated with environmentally
induced cell death. Moreover, different cases of developmental PCD share a set
of cell death-associated genes. Most of these genes are evolutionary conserved
within the green plant lineage, arguing for an evolutionary conserved core machinery
of developmental PCD. Based on this information, we established an array of specific
promoter-reporter lines for developmental PCD in Arabidopsis. These PCD indicators
represent a powerful resource that can be used in addition to established morphological
and biochemical methods to detect and analyze PCD processes in vivo and in planta.
author:
- first_name: Yadira
full_name: Olvera Carrillo, Yadira
last_name: Olvera Carrillo
- first_name: Michiel
full_name: Van Bel, Michiel
last_name: Van Bel
- first_name: Tom
full_name: Van Hautegem, Tom
last_name: Van Hautegem
- first_name: Matyas
full_name: Fendrych, Matyas
id: 43905548-F248-11E8-B48F-1D18A9856A87
last_name: Fendrych
orcid: 0000-0002-9767-8699
- first_name: Marlies
full_name: Huysmans, Marlies
last_name: Huysmans
- first_name: Mária
full_name: Šimášková, Mária
last_name: Šimášková
- first_name: Matthias
full_name: Van Durme, Matthias
last_name: Van Durme
- first_name: Pierre
full_name: Buscaill, Pierre
last_name: Buscaill
- first_name: Susana
full_name: Rivas, Susana
last_name: Rivas
- first_name: Núria
full_name: Coll, Núria
last_name: Coll
- first_name: Frederik
full_name: Coppens, Frederik
last_name: Coppens
- first_name: Steven
full_name: Maere, Steven
last_name: Maere
- first_name: Moritz
full_name: Nowack, Moritz
last_name: Nowack
citation:
ama: Olvera Carrillo Y, Van Bel M, Van Hautegem T, et al. A conserved core of programmed
cell death indicator genes discriminates developmentally and environmentally induced
programmed cell death in plants. Plant Physiology. 2015;169(4):2684-2699.
doi:10.1104/pp.15.00769
apa: Olvera Carrillo, Y., Van Bel, M., Van Hautegem, T., Fendrych, M., Huysmans,
M., Šimášková, M., … Nowack, M. (2015). A conserved core of programmed cell death
indicator genes discriminates developmentally and environmentally induced programmed
cell death in plants. Plant Physiology. American Society of Plant Biologists.
https://doi.org/10.1104/pp.15.00769
chicago: Olvera Carrillo, Yadira, Michiel Van Bel, Tom Van Hautegem, Matyas Fendrych,
Marlies Huysmans, Mária Šimášková, Matthias Van Durme, et al. “A Conserved Core
of Programmed Cell Death Indicator Genes Discriminates Developmentally and Environmentally
Induced Programmed Cell Death in Plants.” Plant Physiology. American Society
of Plant Biologists, 2015. https://doi.org/10.1104/pp.15.00769.
ieee: Y. Olvera Carrillo et al., “A conserved core of programmed cell death
indicator genes discriminates developmentally and environmentally induced programmed
cell death in plants,” Plant Physiology, vol. 169, no. 4. American Society
of Plant Biologists, pp. 2684–2699, 2015.
ista: Olvera Carrillo Y, Van Bel M, Van Hautegem T, Fendrych M, Huysmans M, Šimášková
M, Van Durme M, Buscaill P, Rivas S, Coll N, Coppens F, Maere S, Nowack M. 2015.
A conserved core of programmed cell death indicator genes discriminates developmentally
and environmentally induced programmed cell death in plants. Plant Physiology.
169(4), 2684–2699.
mla: Olvera Carrillo, Yadira, et al. “A Conserved Core of Programmed Cell Death
Indicator Genes Discriminates Developmentally and Environmentally Induced Programmed
Cell Death in Plants.” Plant Physiology, vol. 169, no. 4, American Society
of Plant Biologists, 2015, pp. 2684–99, doi:10.1104/pp.15.00769.
short: Y. Olvera Carrillo, M. Van Bel, T. Van Hautegem, M. Fendrych, M. Huysmans,
M. Šimášková, M. Van Durme, P. Buscaill, S. Rivas, N. Coll, F. Coppens, S. Maere,
M. Nowack, Plant Physiology 169 (2015) 2684–2699.
date_created: 2018-12-11T11:52:38Z
date_published: 2015-12-01T00:00:00Z
date_updated: 2021-01-12T06:51:30Z
day: '01'
department:
- _id: JiFr
doi: 10.1104/pp.15.00769
intvolume: ' 169'
issue: '4'
language:
- iso: eng
month: '12'
oa_version: None
page: 2684 - 2699
publication: Plant Physiology
publication_status: published
publisher: American Society of Plant Biologists
publist_id: '5628'
scopus_import: 1
status: public
title: A conserved core of programmed cell death indicator genes discriminates developmentally
and environmentally induced programmed cell death in plants
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 169
year: '2015'
...
---
_id: '1544'
abstract:
- lang: eng
text: 'Cell division in prokaryotes and eukaryotes is commonly initiated by the
well-controlled binding of proteins to the cytoplasmic side of the cell membrane.
However, a precise characterization of the spatiotemporal dynamics of membrane-bound
proteins is often difficult to achieve in vivo. Here, we present protocols for
the use of supported lipid bilayers to rebuild the cytokinetic machineries of
cells with greatly different dimensions: the bacterium Escherichia coli and eggs
of the vertebrate Xenopus laevis. Combined with total internal reflection fluorescence
microscopy, these experimental setups allow for precise quantitative analyses
of membrane-bound proteins. The protocols described to obtain glass-supported
membranes from bacterial and vertebrate lipids can be used as starting points
for other reconstitution experiments. We believe that similar biochemical assays
will be instrumental to study the biochemistry and biophysics underlying a variety
of complex cellular tasks, such as signaling, vesicle trafficking, and cell motility.'
author:
- first_name: Phuong
full_name: Nguyen, Phuong
last_name: Nguyen
- first_name: Christine
full_name: Field, Christine
last_name: Field
- first_name: Aaron
full_name: Groen, Aaron
last_name: Groen
- first_name: Timothy
full_name: Mitchison, Timothy
last_name: Mitchison
- first_name: Martin
full_name: Loose, Martin
id: 462D4284-F248-11E8-B48F-1D18A9856A87
last_name: Loose
orcid: 0000-0001-7309-9724
citation:
ama: 'Nguyen P, Field C, Groen A, Mitchison T, Loose M. Using supported bilayers
to study the spatiotemporal organization of membrane-bound proteins. In: Building
a Cell from Its Components Parts. Vol 128. Academic Press; 2015:223-241. doi:10.1016/bs.mcb.2015.01.007'
apa: Nguyen, P., Field, C., Groen, A., Mitchison, T., & Loose, M. (2015). Using
supported bilayers to study the spatiotemporal organization of membrane-bound
proteins. In Building a Cell from its Components Parts (Vol. 128, pp. 223–241).
Academic Press. https://doi.org/10.1016/bs.mcb.2015.01.007
chicago: Nguyen, Phuong, Christine Field, Aaron Groen, Timothy Mitchison, and Martin
Loose. “Using Supported Bilayers to Study the Spatiotemporal Organization of Membrane-Bound
Proteins.” In Building a Cell from Its Components Parts, 128:223–41. Academic
Press, 2015. https://doi.org/10.1016/bs.mcb.2015.01.007.
ieee: P. Nguyen, C. Field, A. Groen, T. Mitchison, and M. Loose, “Using supported
bilayers to study the spatiotemporal organization of membrane-bound proteins,”
in Building a Cell from its Components Parts, vol. 128, Academic Press,
2015, pp. 223–241.
ista: 'Nguyen P, Field C, Groen A, Mitchison T, Loose M. 2015.Using supported bilayers
to study the spatiotemporal organization of membrane-bound proteins. In: Building
a Cell from its Components Parts. vol. 128, 223–241.'
mla: Nguyen, Phuong, et al. “Using Supported Bilayers to Study the Spatiotemporal
Organization of Membrane-Bound Proteins.” Building a Cell from Its Components
Parts, vol. 128, Academic Press, 2015, pp. 223–41, doi:10.1016/bs.mcb.2015.01.007.
short: P. Nguyen, C. Field, A. Groen, T. Mitchison, M. Loose, in:, Building a Cell
from Its Components Parts, Academic Press, 2015, pp. 223–241.
date_created: 2018-12-11T11:52:38Z
date_published: 2015-04-08T00:00:00Z
date_updated: 2021-01-12T06:51:30Z
day: '08'
department:
- _id: MaLo
doi: 10.1016/bs.mcb.2015.01.007
external_id:
pmid:
- '25997350'
intvolume: ' 128'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578691/
month: '04'
oa: 1
oa_version: Submitted Version
page: 223 - 241
pmid: 1
publication: Building a Cell from its Components Parts
publication_status: published
publisher: Academic Press
publist_id: '5627'
quality_controlled: '1'
scopus_import: 1
status: public
title: Using supported bilayers to study the spatiotemporal organization of membrane-bound
proteins
type: book_chapter
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 128
year: '2015'
...
---
_id: '1540'
abstract:
- lang: eng
text: 'Plant sexual reproduction involves highly structured and specialized organs:
stamens (male) and gynoecia (female, containing ovules). These organs synchronously
develop within protective flower buds, until anthesis, via tightly coordinated
mechanisms that are essential for effective fertilization and production of viable
seeds. The phytohormone auxin is one of the key endogenous signalling molecules
controlling initiation and development of these, and other, plant organs. In particular,
its uneven distribution, resulting from tightly controlled production, metabolism
and directional transport, is an important morphogenic factor. In this review
we discuss how developmentally controlled and localized auxin biosynthesis and
transport contribute to the coordinated development of plants'' reproductive organs,
and their fertilized derivatives (embryos) via the regulation of auxin levels
and distribution within and around them. Current understanding of the links between
de novo local auxin biosynthesis, auxin transport and/or signalling is presented
to highlight the importance of the non-cell autonomous action of auxin production
on development and morphogenesis of reproductive organs and embryos. An overview
of transcription factor families, which spatiotemporally define local auxin production
by controlling key auxin biosynthetic enzymes, is also presented.'
acknowledgement: 'The work was supported by grants from: the Employment of Best Young
Scientists for International Cooperation Empowerment/OPVKII programme (CZ.1.07/2.3.00/30.0037)
to HSR and LCK; the Czech Science Foundation (GA13-39982S) to EB, LCK and SM; and
the SoMoPro II programme (3SGA5602), cofinanced by the South-Moravian Region and
the EU (FP7/2007–2013 People Programme), to HSR.'
author:
- first_name: Hélène
full_name: Robert, Hélène
last_name: Robert
- first_name: Lucie
full_name: Crhák Khaitová, Lucie
last_name: Crhák Khaitová
- first_name: Souad
full_name: Mroue, Souad
last_name: Mroue
- first_name: Eva
full_name: Benková, Eva
id: 38F4F166-F248-11E8-B48F-1D18A9856A87
last_name: Benková
orcid: 0000-0002-8510-9739
citation:
ama: Robert H, Crhák Khaitová L, Mroue S, Benková E. The importance of localized
auxin production for morphogenesis of reproductive organs and embryos in Arabidopsis.
Journal of Experimental Botany. 2015;66(16):5029-5042. doi:10.1093/jxb/erv256
apa: Robert, H., Crhák Khaitová, L., Mroue, S., & Benková, E. (2015). The importance
of localized auxin production for morphogenesis of reproductive organs and embryos
in Arabidopsis. Journal of Experimental Botany. Oxford University Press.
https://doi.org/10.1093/jxb/erv256
chicago: Robert, Hélène, Lucie Crhák Khaitová, Souad Mroue, and Eva Benková. “The
Importance of Localized Auxin Production for Morphogenesis of Reproductive Organs
and Embryos in Arabidopsis.” Journal of Experimental Botany. Oxford University
Press, 2015. https://doi.org/10.1093/jxb/erv256.
ieee: H. Robert, L. Crhák Khaitová, S. Mroue, and E. Benková, “The importance of
localized auxin production for morphogenesis of reproductive organs and embryos
in Arabidopsis,” Journal of Experimental Botany, vol. 66, no. 16. Oxford
University Press, pp. 5029–5042, 2015.
ista: Robert H, Crhák Khaitová L, Mroue S, Benková E. 2015. The importance of localized
auxin production for morphogenesis of reproductive organs and embryos in Arabidopsis.
Journal of Experimental Botany. 66(16), 5029–5042.
mla: Robert, Hélène, et al. “The Importance of Localized Auxin Production for Morphogenesis
of Reproductive Organs and Embryos in Arabidopsis.” Journal of Experimental
Botany, vol. 66, no. 16, Oxford University Press, 2015, pp. 5029–42, doi:10.1093/jxb/erv256.
short: H. Robert, L. Crhák Khaitová, S. Mroue, E. Benková, Journal of Experimental
Botany 66 (2015) 5029–5042.
date_created: 2018-12-11T11:52:36Z
date_published: 2015-05-05T00:00:00Z
date_updated: 2021-01-12T06:51:29Z
day: '05'
department:
- _id: EvBe
doi: 10.1093/jxb/erv256
intvolume: ' 66'
issue: '16'
language:
- iso: eng
month: '05'
oa_version: None
page: 5029 - 5042
publication: Journal of Experimental Botany
publication_status: published
publisher: Oxford University Press
publist_id: '5631'
quality_controlled: '1'
scopus_import: 1
status: public
title: The importance of localized auxin production for morphogenesis of reproductive
organs and embryos in Arabidopsis
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 66
year: '2015'
...
---
_id: '1551'
abstract:
- lang: eng
text: 'Reciprocal coevolution between host and pathogen is widely seen as a major
driver of evolution and biological innovation. Yet, to date, the underlying genetic
mechanisms and associated trait functions that are unique to rapid coevolutionary
change are generally unknown. We here combined experimental evolution of the bacterial
biocontrol agent Bacillus thuringiensis and its nematode host Caenorhabditis elegans
with large-scale phenotyping, whole genome analysis, and functional genetics to
demonstrate the selective benefit of pathogen virulence and the underlying toxin
genes during the adaptation process. We show that: (i) high virulence was specifically
favoured during pathogen–host coevolution rather than pathogen one-sided adaptation
to a nonchanging host or to an environment without host; (ii) the pathogen genotype
BT-679 with known nematocidal toxin genes and high virulence specifically swept
to fixation in all of the independent replicate populations under coevolution
but only some under one-sided adaptation; (iii) high virulence in the BT-679-dominated
populations correlated with elevated copy numbers of the plasmid containing the
nematocidal toxin genes; (iv) loss of virulence in a toxin-plasmid lacking BT-679
isolate was reconstituted by genetic reintroduction or external addition of the
toxins.We conclude that sustained coevolution is distinct from unidirectional
selection in shaping the pathogen''s genome and life history characteristics.
To our knowledge, this study is the first to characterize the pathogen genes involved
in coevolutionary adaptation in an animal host–pathogen interaction system.'
acknowledgement: We are very grateful for funding from the German Science Foundation
(DFG) to HS (SCHU 1415/8, SCHU 1415/9), PR (RO 2994/3), EBB (BO 2544/7), HL (LI
1690/2), AT (TE 976/2), RDS (SCHU 2522/1), JK (KU 1929/4); from the Kiel Excellence
Cluster Inflammation at Interfaces to HS and PR; and from the ISTFELLOW program
(Co-fund Marie Curie Actions of the European Commission) to LM.
author:
- first_name: Leila
full_name: El Masri, Leila
id: 349A6E66-F248-11E8-B48F-1D18A9856A87
last_name: El Masri
- first_name: Antoine
full_name: Branca, Antoine
last_name: Branca
- first_name: Anna
full_name: Sheppard, Anna
last_name: Sheppard
- first_name: Andrei
full_name: Papkou, Andrei
last_name: Papkou
- first_name: David
full_name: Laehnemann, David
last_name: Laehnemann
- first_name: Patrick
full_name: Guenther, Patrick
last_name: Guenther
- first_name: Swantje
full_name: Prahl, Swantje
last_name: Prahl
- first_name: Manja
full_name: Saebelfeld, Manja
last_name: Saebelfeld
- first_name: Jacqueline
full_name: Hollensteiner, Jacqueline
last_name: Hollensteiner
- first_name: Heiko
full_name: Liesegang, Heiko
last_name: Liesegang
- first_name: Elzbieta
full_name: Brzuszkiewicz, Elzbieta
last_name: Brzuszkiewicz
- first_name: Rolf
full_name: Daniel, Rolf
last_name: Daniel
- first_name: Nico
full_name: Michiels, Nico
last_name: Michiels
- first_name: Rebecca
full_name: Schulte, Rebecca
last_name: Schulte
- first_name: Joachim
full_name: Kurtz, Joachim
last_name: Kurtz
- first_name: Philip
full_name: Rosenstiel, Philip
last_name: Rosenstiel
- first_name: Arndt
full_name: Telschow, Arndt
last_name: Telschow
- first_name: Erich
full_name: Bornberg Bauer, Erich
last_name: Bornberg Bauer
- first_name: Hinrich
full_name: Schulenburg, Hinrich
last_name: Schulenburg
citation:
ama: 'El Masri L, Branca A, Sheppard A, et al. Host–pathogen coevolution: The selective
advantage of Bacillus thuringiensis virulence and its cry toxin genes. PLoS
Biology. 2015;13(6):1-30. doi:10.1371/journal.pbio.1002169'
apa: 'El Masri, L., Branca, A., Sheppard, A., Papkou, A., Laehnemann, D., Guenther,
P., … Schulenburg, H. (2015). Host–pathogen coevolution: The selective advantage
of Bacillus thuringiensis virulence and its cry toxin genes. PLoS Biology.
Public Library of Science. https://doi.org/10.1371/journal.pbio.1002169'
chicago: 'El Masri, Leila, Antoine Branca, Anna Sheppard, Andrei Papkou, David Laehnemann,
Patrick Guenther, Swantje Prahl, et al. “Host–Pathogen Coevolution: The Selective
Advantage of Bacillus Thuringiensis Virulence and Its Cry Toxin Genes.” PLoS
Biology. Public Library of Science, 2015. https://doi.org/10.1371/journal.pbio.1002169.'
ieee: 'L. El Masri et al., “Host–pathogen coevolution: The selective advantage
of Bacillus thuringiensis virulence and its cry toxin genes,” PLoS Biology,
vol. 13, no. 6. Public Library of Science, pp. 1–30, 2015.'
ista: 'El Masri L, Branca A, Sheppard A, Papkou A, Laehnemann D, Guenther P, Prahl
S, Saebelfeld M, Hollensteiner J, Liesegang H, Brzuszkiewicz E, Daniel R, Michiels
N, Schulte R, Kurtz J, Rosenstiel P, Telschow A, Bornberg Bauer E, Schulenburg
H. 2015. Host–pathogen coevolution: The selective advantage of Bacillus thuringiensis
virulence and its cry toxin genes. PLoS Biology. 13(6), 1–30.'
mla: 'El Masri, Leila, et al. “Host–Pathogen Coevolution: The Selective Advantage
of Bacillus Thuringiensis Virulence and Its Cry Toxin Genes.” PLoS Biology,
vol. 13, no. 6, Public Library of Science, 2015, pp. 1–30, doi:10.1371/journal.pbio.1002169.'
short: L. El Masri, A. Branca, A. Sheppard, A. Papkou, D. Laehnemann, P. Guenther,
S. Prahl, M. Saebelfeld, J. Hollensteiner, H. Liesegang, E. Brzuszkiewicz, R.
Daniel, N. Michiels, R. Schulte, J. Kurtz, P. Rosenstiel, A. Telschow, E. Bornberg
Bauer, H. Schulenburg, PLoS Biology 13 (2015) 1–30.
date_created: 2018-12-11T11:52:40Z
date_published: 2015-06-04T00:00:00Z
date_updated: 2021-01-12T06:51:33Z
day: '04'
ddc:
- '570'
department:
- _id: SyCr
doi: 10.1371/journal.pbio.1002169
ec_funded: 1
file:
- access_level: open_access
checksum: 30dee7a2c11ed09f2f5634655c0146f8
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:14:13Z
date_updated: 2020-07-14T12:45:02Z
file_id: '5063'
file_name: IST-2016-481-v1+1_journal.pbio.1002169.pdf
file_size: 3468956
relation: main_file
file_date_updated: 2020-07-14T12:45:02Z
has_accepted_license: '1'
intvolume: ' 13'
issue: '6'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: 1 - 30
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication: PLoS Biology
publication_status: published
publisher: Public Library of Science
publist_id: '5620'
pubrep_id: '481'
quality_controlled: '1'
scopus_import: 1
status: public
title: 'Host–pathogen coevolution: The selective advantage of Bacillus thuringiensis
virulence and its cry toxin genes'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 13
year: '2015'
...
---
_id: '1549'
abstract:
- lang: eng
text: Nature has incorporated small photochromic molecules, colloquially termed
'photoswitches', in photoreceptor proteins to sense optical cues in photo-taxis
and vision. While Nature's ability to employ light-responsive functionalities
has long been recognized, it was not until recently that scientists designed,
synthesized and applied synthetic photochromes to manipulate many of which open
rapidly and locally in their native cell types, biological processes with the
temporal and spatial resolution of light. Ion channels in particular have come
to the forefront of proteins that can be put under the designer control of synthetic
photochromes. Photochromic ion channel controllers are comprised of three classes,
photochromic soluble ligands (PCLs), photochromic tethered ligands (PTLs) and
photochromic crosslinkers (PXs), and in each class ion channel functionality is
controlled through reversible changes in photochrome structure. By acting as light-dependent
ion channel agonists, antagonist or modulators, photochromic controllers effectively
converted a wide range of ion channels, including voltage-gated ion channels,
'leak channels', tri-, tetra- and pentameric ligand-gated ion channels, and temperaturesensitive
ion channels, into man-made photoreceptors. Control by photochromes can be reversible,
unlike in the case of 'caged' compounds, and non-invasive with high spatial precision,
unlike pharmacology and electrical manipulation. Here, we introduce design principles
of emerging photochromic molecules that act on ion channels and discuss the impact
that these molecules are beginning to have on ion channel biophysics and neuronal
physiology.
author:
- first_name: Catherine
full_name: Mckenzie, Catherine
id: 3EEDE19A-F248-11E8-B48F-1D18A9856A87
last_name: Mckenzie
- first_name: Inmaculada
full_name: Sanchez Romero, Inmaculada
id: 3D9C5D30-F248-11E8-B48F-1D18A9856A87
last_name: Sanchez Romero
- first_name: Harald L
full_name: Janovjak, Harald L
id: 33BA6C30-F248-11E8-B48F-1D18A9856A87
last_name: Janovjak
orcid: 0000-0002-8023-9315
citation:
ama: 'Mckenzie C, Sanchez-Romero I, Janovjak HL. Flipping the photoswitch: Ion channels
under light control. In: Novel Chemical Tools to Study Ion Channel Biology.
Vol 869. Advances in Experimental Medicine and Biology. Springer; 2015:101-117.
doi:10.1007/978-1-4939-2845-3_6'
apa: 'Mckenzie, C., Sanchez-Romero, I., & Janovjak, H. L. (2015). Flipping the
photoswitch: Ion channels under light control. In Novel chemical tools to study
ion channel biology (Vol. 869, pp. 101–117). Springer. https://doi.org/10.1007/978-1-4939-2845-3_6'
chicago: 'Mckenzie, Catherine, Inmaculada Sanchez-Romero, and Harald L Janovjak.
“Flipping the Photoswitch: Ion Channels under Light Control.” In Novel Chemical
Tools to Study Ion Channel Biology, 869:101–17. Advances in Experimental Medicine
and Biology. Springer, 2015. https://doi.org/10.1007/978-1-4939-2845-3_6.'
ieee: 'C. Mckenzie, I. Sanchez-Romero, and H. L. Janovjak, “Flipping the photoswitch:
Ion channels under light control,” in Novel chemical tools to study ion channel
biology, vol. 869, Springer, 2015, pp. 101–117.'
ista: 'Mckenzie C, Sanchez-Romero I, Janovjak HL. 2015.Flipping the photoswitch:
Ion channels under light control. In: Novel chemical tools to study ion channel
biology. vol. 869, 101–117.'
mla: 'Mckenzie, Catherine, et al. “Flipping the Photoswitch: Ion Channels under
Light Control.” Novel Chemical Tools to Study Ion Channel Biology, vol.
869, Springer, 2015, pp. 101–17, doi:10.1007/978-1-4939-2845-3_6.'
short: C. Mckenzie, I. Sanchez-Romero, H.L. Janovjak, in:, Novel Chemical Tools
to Study Ion Channel Biology, Springer, 2015, pp. 101–117.
date_created: 2018-12-11T11:52:39Z
date_published: 2015-09-18T00:00:00Z
date_updated: 2021-01-12T06:51:32Z
day: '18'
ddc:
- '571'
- '576'
department:
- _id: HaJa
doi: 10.1007/978-1-4939-2845-3_6
file:
- access_level: open_access
checksum: bd1bfdf2423a0c3b6e7cabfa8b44bc0f
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:11:02Z
date_updated: 2020-07-14T12:45:01Z
file_id: '4854'
file_name: IST-2017-839-v1+1_mckenzie.pdf
file_size: 1919655
relation: main_file
file_date_updated: 2020-07-14T12:45:01Z
has_accepted_license: '1'
intvolume: ' 869'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Submitted Version
page: 101 - 117
publication: Novel chemical tools to study ion channel biology
publication_identifier:
isbn:
- 978-1-4939-2844-6
publication_status: published
publisher: Springer
publist_id: '5622'
pubrep_id: '839'
quality_controlled: '1'
scopus_import: 1
series_title: Advances in Experimental Medicine and Biology
status: public
title: 'Flipping the photoswitch: Ion channels under light control'
type: book_chapter
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 869
year: '2015'
...
---
_id: '1548'
abstract:
- lang: eng
text: Reproduction within a host and transmission to the next host are crucial for
the virulence and fitness of pathogens. Nevertheless, basic knowledge about such
parameters is often missing from the literature, even for well-studied bacteria,
such as Bacillus thuringiensis, an endospore-forming insect pathogen, which infects
its hosts via the oral route. To characterize bacterial replication success, we
made use of an experimental oral infection system for the red flour beetle Tribolium
castaneum and developed a flow cytometric assay for the quantification of both
spore ingestion by the individual beetle larvae and the resulting spore load after
bacterial replication and resporulation within cadavers. On average, spore numbers
increased 460-fold, showing that Bacillus thuringiensis grows and replicates successfully
in insect cadavers. By inoculating cadaver-derived spores and spores from bacterial
stock cultures into nutrient medium, we next investigated outgrowth characteristics
of vegetative cells and found that cadaver- derived bacteria showed reduced growth
compared to bacteria from the stock cultures. Interestingly, this reduced growth
was a consequence of inhibited spore germination, probably originating from the
host and resulting in reduced host mortality in subsequent infections by cadaver-derived
spores. Nevertheless, we further showed that Bacillus thuringiensis transmission
was possible via larval cannibalism when no other food was offered. These results
contribute to our understanding of the ecology of Bacillus thuringiensis as an
insect pathogen.
author:
- first_name: Barbara
full_name: Milutinovic, Barbara
id: 2CDC32B8-F248-11E8-B48F-1D18A9856A87
last_name: Milutinovic
orcid: 0000-0002-8214-4758
- first_name: Christina
full_name: Höfling, Christina
last_name: Höfling
- first_name: Momir
full_name: Futo, Momir
last_name: Futo
- first_name: Jörn
full_name: Scharsack, Jörn
last_name: Scharsack
- first_name: Joachim
full_name: Kurtz, Joachim
last_name: Kurtz
citation:
ama: 'Milutinovic B, Höfling C, Futo M, Scharsack J, Kurtz J. Infection of Tribolium
castaneum with Bacillus thuringiensis: Quantification of bacterial replication
within cadavers, transmission via cannibalism, and inhibition of spore germination.
Applied and Environmental Microbiology. 2015;81(23):8135-8144. doi:10.1128/AEM.02051-15'
apa: 'Milutinovic, B., Höfling, C., Futo, M., Scharsack, J., & Kurtz, J. (2015).
Infection of Tribolium castaneum with Bacillus thuringiensis: Quantification of
bacterial replication within cadavers, transmission via cannibalism, and inhibition
of spore germination. Applied and Environmental Microbiology. American
Society for Microbiology. https://doi.org/10.1128/AEM.02051-15'
chicago: 'Milutinovic, Barbara, Christina Höfling, Momir Futo, Jörn Scharsack, and
Joachim Kurtz. “Infection of Tribolium Castaneum with Bacillus Thuringiensis:
Quantification of Bacterial Replication within Cadavers, Transmission via Cannibalism,
and Inhibition of Spore Germination.” Applied and Environmental Microbiology.
American Society for Microbiology, 2015. https://doi.org/10.1128/AEM.02051-15.'
ieee: 'B. Milutinovic, C. Höfling, M. Futo, J. Scharsack, and J. Kurtz, “Infection
of Tribolium castaneum with Bacillus thuringiensis: Quantification of bacterial
replication within cadavers, transmission via cannibalism, and inhibition of spore
germination,” Applied and Environmental Microbiology, vol. 81, no. 23.
American Society for Microbiology, pp. 8135–8144, 2015.'
ista: 'Milutinovic B, Höfling C, Futo M, Scharsack J, Kurtz J. 2015. Infection of
Tribolium castaneum with Bacillus thuringiensis: Quantification of bacterial replication
within cadavers, transmission via cannibalism, and inhibition of spore germination.
Applied and Environmental Microbiology. 81(23), 8135–8144.'
mla: 'Milutinovic, Barbara, et al. “Infection of Tribolium Castaneum with Bacillus
Thuringiensis: Quantification of Bacterial Replication within Cadavers, Transmission
via Cannibalism, and Inhibition of Spore Germination.” Applied and Environmental
Microbiology, vol. 81, no. 23, American Society for Microbiology, 2015, pp.
8135–44, doi:10.1128/AEM.02051-15.'
short: B. Milutinovic, C. Höfling, M. Futo, J. Scharsack, J. Kurtz, Applied and
Environmental Microbiology 81 (2015) 8135–8144.
date_created: 2018-12-11T11:52:39Z
date_published: 2015-12-01T00:00:00Z
date_updated: 2021-01-12T06:51:31Z
day: '01'
department:
- _id: SyCr
doi: 10.1128/AEM.02051-15
external_id:
pmid:
- '26386058'
intvolume: ' 81'
issue: '23'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651099/
month: '12'
oa: 1
oa_version: Submitted Version
page: 8135 - 8144
pmid: 1
publication: Applied and Environmental Microbiology
publication_status: published
publisher: American Society for Microbiology
publist_id: '5623'
quality_controlled: '1'
scopus_import: 1
status: public
title: 'Infection of Tribolium castaneum with Bacillus thuringiensis: Quantification
of bacterial replication within cadavers, transmission via cannibalism, and inhibition
of spore germination'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 81
year: '2015'
...
---
_id: '1553'
abstract:
- lang: eng
text: Cell movement has essential functions in development, immunity, and cancer.
Various cell migration patterns have been reported, but no general rule has emerged
so far. Here, we show on the basis of experimental data in vitro and in vivo that
cell persistence, which quantifies the straightness of trajectories, is robustly
coupled to cell migration speed. We suggest that this universal coupling constitutes
a generic law of cell migration, which originates in the advection of polarity
cues by an actin cytoskeleton undergoing flows at the cellular scale. Our analysis
relies on a theoretical model that we validate by measuring the persistence of
cells upon modulation of actin flow speeds and upon optogenetic manipulation of
the binding of an actin regulator to actin filaments. Beyond the quantitative
prediction of the coupling, the model yields a generic phase diagram of cellular
trajectories, which recapitulates the full range of observed migration patterns.
author:
- first_name: Paolo
full_name: Maiuri, Paolo
last_name: Maiuri
- first_name: Jean
full_name: Rupprecht, Jean
last_name: Rupprecht
- first_name: Stefan
full_name: Wieser, Stefan
id: 355AA5A0-F248-11E8-B48F-1D18A9856A87
last_name: Wieser
orcid: 0000-0002-2670-2217
- first_name: Verena
full_name: Ruprecht, Verena
id: 4D71A03A-F248-11E8-B48F-1D18A9856A87
last_name: Ruprecht
orcid: 0000-0003-4088-8633
- first_name: Olivier
full_name: Bénichou, Olivier
last_name: Bénichou
- first_name: Nicolas
full_name: Carpi, Nicolas
last_name: Carpi
- first_name: Mathieu
full_name: Coppey, Mathieu
last_name: Coppey
- first_name: Simon
full_name: De Beco, Simon
last_name: De Beco
- first_name: Nir
full_name: Gov, Nir
last_name: Gov
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Carolina
full_name: Lage Crespo, Carolina
last_name: Lage Crespo
- first_name: Franziska
full_name: Lautenschlaeger, Franziska
last_name: Lautenschlaeger
- first_name: Maël
full_name: Le Berre, Maël
last_name: Le Berre
- first_name: Ana
full_name: Lennon Duménil, Ana
last_name: Lennon Duménil
- first_name: Matthew
full_name: Raab, Matthew
last_name: Raab
- first_name: Hawa
full_name: Thiam, Hawa
last_name: Thiam
- first_name: Matthieu
full_name: Piel, Matthieu
last_name: Piel
- first_name: Michael K
full_name: Sixt, Michael K
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
- first_name: Raphaël
full_name: Voituriez, Raphaël
last_name: Voituriez
citation:
ama: Maiuri P, Rupprecht J, Wieser S, et al. Actin flows mediate a universal coupling
between cell speed and cell persistence. Cell. 2015;161(2):374-386. doi:10.1016/j.cell.2015.01.056
apa: Maiuri, P., Rupprecht, J., Wieser, S., Ruprecht, V., Bénichou, O., Carpi, N.,
… Voituriez, R. (2015). Actin flows mediate a universal coupling between cell
speed and cell persistence. Cell. Cell Press. https://doi.org/10.1016/j.cell.2015.01.056
chicago: Maiuri, Paolo, Jean Rupprecht, Stefan Wieser, Verena Ruprecht, Olivier
Bénichou, Nicolas Carpi, Mathieu Coppey, et al. “Actin Flows Mediate a Universal
Coupling between Cell Speed and Cell Persistence.” Cell. Cell Press, 2015.
https://doi.org/10.1016/j.cell.2015.01.056.
ieee: P. Maiuri et al., “Actin flows mediate a universal coupling between
cell speed and cell persistence,” Cell, vol. 161, no. 2. Cell Press, pp.
374–386, 2015.
ista: Maiuri P, Rupprecht J, Wieser S, Ruprecht V, Bénichou O, Carpi N, Coppey M,
De Beco S, Gov N, Heisenberg C-PJ, Lage Crespo C, Lautenschlaeger F, Le Berre
M, Lennon Duménil A, Raab M, Thiam H, Piel M, Sixt MK, Voituriez R. 2015. Actin
flows mediate a universal coupling between cell speed and cell persistence. Cell.
161(2), 374–386.
mla: Maiuri, Paolo, et al. “Actin Flows Mediate a Universal Coupling between Cell
Speed and Cell Persistence.” Cell, vol. 161, no. 2, Cell Press, 2015, pp.
374–86, doi:10.1016/j.cell.2015.01.056.
short: P. Maiuri, J. Rupprecht, S. Wieser, V. Ruprecht, O. Bénichou, N. Carpi, M.
Coppey, S. De Beco, N. Gov, C.-P.J. Heisenberg, C. Lage Crespo, F. Lautenschlaeger,
M. Le Berre, A. Lennon Duménil, M. Raab, H. Thiam, M. Piel, M.K. Sixt, R. Voituriez,
Cell 161 (2015) 374–386.
date_created: 2018-12-11T11:52:41Z
date_published: 2015-04-09T00:00:00Z
date_updated: 2021-01-12T06:51:33Z
day: '09'
department:
- _id: MiSi
- _id: CaHe
doi: 10.1016/j.cell.2015.01.056
ec_funded: 1
intvolume: ' 161'
issue: '2'
language:
- iso: eng
month: '04'
oa_version: None
page: 374 - 386
project:
- _id: 2529486C-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: T 560-B17
name: Cell- and Tissue Mechanics in Zebrafish Germ Layer Formation
- _id: 25A603A2-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '281556'
name: Cytoskeletal force generation and force transduction of migrating leukocytes
(EU)
- _id: 25ABD200-B435-11E9-9278-68D0E5697425
grant_number: RGP0058/2011
name: 'Cell migration in complex environments: from in vivo experiments to theoretical
models'
publication: Cell
publication_status: published
publisher: Cell Press
publist_id: '5618'
quality_controlled: '1'
scopus_import: 1
status: public
title: Actin flows mediate a universal coupling between cell speed and cell persistence
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 161
year: '2015'
...
---
_id: '1550'
abstract:
- lang: eng
text: The medial ganglionic eminence (MGE) gives rise to the majority of mouse forebrain
interneurons. Here, we examine the lineage relationship among MGE-derived interneurons
using a replication-defective retroviral library containing a highly diverse set
of DNA barcodes. Recovering the barcodes from the mature progeny of infected progenitor
cells enabled us to unambiguously determine their respective lineal relationship.
We found that clonal dispersion occurs across large areas of the brain and is
not restricted by anatomical divisions. As such, sibling interneurons can populate
the cortex, hippocampus striatum, and globus pallidus. The majority of interneurons
appeared to be generated from asymmetric divisions of MGE progenitor cells, followed
by symmetric divisions within the subventricular zone. Altogether, our findings
uncover that lineage relationships do not appear to determine interneuron allocation
to particular regions. As such, it is likely that clonally related interneurons
have considerable flexibility as to the particular forebrain circuits to which
they can contribute.
acknowledgement: "Research in the G.F. laboratory is supported by NIH (NS 081297,
MH095147, and P01NS074972) and the Simons Foundation. Research in the S.H. laboratory
is supported by the European Union (FP7-CIG618444). C.M. is supported by EMBO ALTF
(1295-2012). X.H.J. is supported by EMBO (ALTF 303-2010) and HFSP (LT000078/2011-L).\r\n\r\n"
author:
- first_name: Christian
full_name: Mayer, Christian
last_name: Mayer
- first_name: Xavier
full_name: Jaglin, Xavier
last_name: Jaglin
- first_name: Lucy
full_name: Cobbs, Lucy
last_name: Cobbs
- first_name: Rachel
full_name: Bandler, Rachel
last_name: Bandler
- first_name: Carmen
full_name: Streicher, Carmen
id: 36BCB99C-F248-11E8-B48F-1D18A9856A87
last_name: Streicher
- first_name: Constance
full_name: Cepko, Constance
last_name: Cepko
- first_name: Simon
full_name: Hippenmeyer, Simon
id: 37B36620-F248-11E8-B48F-1D18A9856A87
last_name: Hippenmeyer
orcid: 0000-0003-2279-1061
- first_name: Gord
full_name: Fishell, Gord
last_name: Fishell
citation:
ama: Mayer C, Jaglin X, Cobbs L, et al. Clonally related forebrain interneurons
disperse broadly across both functional areas and structural boundaries. Neuron.
2015;87(5):989-998. doi:10.1016/j.neuron.2015.07.011
apa: Mayer, C., Jaglin, X., Cobbs, L., Bandler, R., Streicher, C., Cepko, C., …
Fishell, G. (2015). Clonally related forebrain interneurons disperse broadly across
both functional areas and structural boundaries. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2015.07.011
chicago: Mayer, Christian, Xavier Jaglin, Lucy Cobbs, Rachel Bandler, Carmen Streicher,
Constance Cepko, Simon Hippenmeyer, and Gord Fishell. “Clonally Related Forebrain
Interneurons Disperse Broadly across Both Functional Areas and Structural Boundaries.”
Neuron. Elsevier, 2015. https://doi.org/10.1016/j.neuron.2015.07.011.
ieee: C. Mayer et al., “Clonally related forebrain interneurons disperse
broadly across both functional areas and structural boundaries,” Neuron,
vol. 87, no. 5. Elsevier, pp. 989–998, 2015.
ista: Mayer C, Jaglin X, Cobbs L, Bandler R, Streicher C, Cepko C, Hippenmeyer S,
Fishell G. 2015. Clonally related forebrain interneurons disperse broadly across
both functional areas and structural boundaries. Neuron. 87(5), 989–998.
mla: Mayer, Christian, et al. “Clonally Related Forebrain Interneurons Disperse
Broadly across Both Functional Areas and Structural Boundaries.” Neuron,
vol. 87, no. 5, Elsevier, 2015, pp. 989–98, doi:10.1016/j.neuron.2015.07.011.
short: C. Mayer, X. Jaglin, L. Cobbs, R. Bandler, C. Streicher, C. Cepko, S. Hippenmeyer,
G. Fishell, Neuron 87 (2015) 989–998.
date_created: 2018-12-11T11:52:40Z
date_published: 2015-09-02T00:00:00Z
date_updated: 2021-01-12T06:51:32Z
day: '02'
department:
- _id: SiHi
doi: 10.1016/j.neuron.2015.07.011
external_id:
pmid:
- '26299473'
intvolume: ' 87'
issue: '5'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560602/
month: '09'
oa: 1
oa_version: Submitted Version
page: 989 - 998
pmid: 1
publication: Neuron
publication_status: published
publisher: Elsevier
publist_id: '5621'
quality_controlled: '1'
scopus_import: 1
status: public
title: Clonally related forebrain interneurons disperse broadly across both functional
areas and structural boundaries
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 87
year: '2015'
...
---
_id: '1547'
abstract:
- lang: eng
text: Let G be a graph on the vertex set V(G) = {x1,…,xn} with the edge set E(G),
and let R = K[x1,…, xn] be the polynomial ring over a field K. Two monomial ideals
are associated to G, the edge ideal I(G) generated by all monomials xixj with
{xi,xj} ∈ E(G), and the vertex cover ideal IG generated by monomials ∏xi∈Cxi for
all minimal vertex covers C of G. A minimal vertex cover of G is a subset C ⊂
V(G) such that each edge has at least one vertex in C and no proper subset of
C has the same property. Indeed, the vertex cover ideal of G is the Alexander
dual of the edge ideal of G. In this paper, for an unmixed bipartite graph G we
consider the lattice of vertex covers LG and we explicitly describe the minimal
free resolution of the ideal associated to LG which is exactly the vertex cover
ideal of G. Then we compute depth, projective dimension, regularity and extremal
Betti numbers of R/I(G) in terms of the associated lattice.
author:
- first_name: Fatemeh
full_name: Mohammadi, Fatemeh
id: 2C29581E-F248-11E8-B48F-1D18A9856A87
last_name: Mohammadi
- first_name: Somayeh
full_name: Moradi, Somayeh
last_name: Moradi
citation:
ama: Mohammadi F, Moradi S. Resolution of unmixed bipartite graphs. Bulletin
of the Korean Mathematical Society. 2015;52(3):977-986. doi:10.4134/BKMS.2015.52.3.977
apa: Mohammadi, F., & Moradi, S. (2015). Resolution of unmixed bipartite graphs.
Bulletin of the Korean Mathematical Society. Korean Mathematical Society.
https://doi.org/10.4134/BKMS.2015.52.3.977
chicago: Mohammadi, Fatemeh, and Somayeh Moradi. “Resolution of Unmixed Bipartite
Graphs.” Bulletin of the Korean Mathematical Society. Korean Mathematical
Society, 2015. https://doi.org/10.4134/BKMS.2015.52.3.977.
ieee: F. Mohammadi and S. Moradi, “Resolution of unmixed bipartite graphs,” Bulletin
of the Korean Mathematical Society, vol. 52, no. 3. Korean Mathematical Society,
pp. 977–986, 2015.
ista: Mohammadi F, Moradi S. 2015. Resolution of unmixed bipartite graphs. Bulletin
of the Korean Mathematical Society. 52(3), 977–986.
mla: Mohammadi, Fatemeh, and Somayeh Moradi. “Resolution of Unmixed Bipartite Graphs.”
Bulletin of the Korean Mathematical Society, vol. 52, no. 3, Korean Mathematical
Society, 2015, pp. 977–86, doi:10.4134/BKMS.2015.52.3.977.
short: F. Mohammadi, S. Moradi, Bulletin of the Korean Mathematical Society 52 (2015)
977–986.
date_created: 2018-12-11T11:52:39Z
date_published: 2015-05-31T00:00:00Z
date_updated: 2021-01-12T06:51:31Z
day: '31'
department:
- _id: CaUh
doi: 10.4134/BKMS.2015.52.3.977
intvolume: ' 52'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/0901.3015
month: '05'
oa: 1
oa_version: Preprint
page: 977 - 986
publication: Bulletin of the Korean Mathematical Society
publication_identifier:
eissn:
- 2234-3016
publication_status: published
publisher: Korean Mathematical Society
publist_id: '5624'
quality_controlled: '1'
scopus_import: 1
status: public
title: Resolution of unmixed bipartite graphs
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 52
year: '2015'
...
---
_id: '1556'
abstract:
- lang: eng
text: The elongator complex subunit 2 (ELP2) protein, one subunit of an evolutionarily
conserved histone acetyltransferase complex, has been shown to participate in
leaf patterning, plant immune and abiotic stress responses in Arabidopsis thaliana.
Here, its role in root development was explored. Compared to the wild type, the
elp2 mutant exhibited an accelerated differentiation of its root stem cells and
cell division was more active in its quiescent centre (QC). The key transcription
factors responsible for maintaining root stem cell and QC identity, such as AP2
transcription factors PLT1 (PLETHORA1) and PLT2 (PLETHORA2), GRAS transcription
factors such as SCR (SCARECROW) and SHR (SHORT ROOT) and WUSCHEL-RELATED HOMEOBOX5
transcription factor WOX5, were all strongly down-regulated in the mutant. On
the other hand, expression of the G2/M transition activator CYCB1 was substantially
induced in elp2. The auxin efflux transporters PIN1 and PIN2 showed decreased
protein levels and PIN1 also displayed mild polarity alterations in elp2, which
resulted in a reduced auxin content in the root tip. Either the acetylation or
methylation level of each of these genes differed between the mutant and the wild
type, suggesting that the ELP2 regulation of root development involves the epigenetic
modification of a range of transcription factors and other developmental regulators.
author:
- first_name: Yuebin
full_name: Jia, Yuebin
last_name: Jia
- first_name: Huiyu
full_name: Tian, Huiyu
last_name: Tian
- first_name: Hongjiang
full_name: Li, Hongjiang
id: 33CA54A6-F248-11E8-B48F-1D18A9856A87
last_name: Li
orcid: 0000-0001-5039-9660
- first_name: Qianqian
full_name: Yu, Qianqian
last_name: Yu
- first_name: Lei
full_name: Wang, Lei
last_name: Wang
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Zhaojun
full_name: Ding, Zhaojun
last_name: Ding
citation:
ama: Jia Y, Tian H, Li H, et al. The Arabidopsis thaliana elongator complex subunit
2 epigenetically affects root development. Journal of Experimental Botany.
2015;66(15):4631-4642. doi:10.1093/jxb/erv230
apa: Jia, Y., Tian, H., Li, H., Yu, Q., Wang, L., Friml, J., & Ding, Z. (2015).
The Arabidopsis thaliana elongator complex subunit 2 epigenetically affects root
development. Journal of Experimental Botany. Oxford University Press. https://doi.org/10.1093/jxb/erv230
chicago: Jia, Yuebin, Huiyu Tian, Hongjiang Li, Qianqian Yu, Lei Wang, Jiří Friml,
and Zhaojun Ding. “The Arabidopsis Thaliana Elongator Complex Subunit 2 Epigenetically
Affects Root Development.” Journal of Experimental Botany. Oxford University
Press, 2015. https://doi.org/10.1093/jxb/erv230.
ieee: Y. Jia et al., “The Arabidopsis thaliana elongator complex subunit
2 epigenetically affects root development,” Journal of Experimental Botany,
vol. 66, no. 15. Oxford University Press, pp. 4631–4642, 2015.
ista: Jia Y, Tian H, Li H, Yu Q, Wang L, Friml J, Ding Z. 2015. The Arabidopsis
thaliana elongator complex subunit 2 epigenetically affects root development.
Journal of Experimental Botany. 66(15), 4631–4642.
mla: Jia, Yuebin, et al. “The Arabidopsis Thaliana Elongator Complex Subunit 2 Epigenetically
Affects Root Development.” Journal of Experimental Botany, vol. 66, no.
15, Oxford University Press, 2015, pp. 4631–42, doi:10.1093/jxb/erv230.
short: Y. Jia, H. Tian, H. Li, Q. Yu, L. Wang, J. Friml, Z. Ding, Journal of Experimental
Botany 66 (2015) 4631–4642.
date_created: 2018-12-11T11:52:42Z
date_published: 2015-08-01T00:00:00Z
date_updated: 2021-01-12T06:51:35Z
day: '01'
ddc:
- '570'
department:
- _id: JiFr
doi: 10.1093/jxb/erv230
file:
- access_level: open_access
checksum: 257919be0ce3d306185d3891ad7acf39
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:14:02Z
date_updated: 2020-07-14T12:45:02Z
file_id: '5051'
file_name: IST-2016-480-v1+1_J._Exp._Bot.-2015-Jia-4631-42.pdf
file_size: 7753043
relation: main_file
file_date_updated: 2020-07-14T12:45:02Z
has_accepted_license: '1'
intvolume: ' 66'
issue: '15'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: 4631 - 4642
publication: Journal of Experimental Botany
publication_status: published
publisher: Oxford University Press
publist_id: '5615'
pubrep_id: '480'
quality_controlled: '1'
scopus_import: 1
status: public
title: The Arabidopsis thaliana elongator complex subunit 2 epigenetically affects
root development
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 66
year: '2015'
...
---
_id: '1555'
abstract:
- lang: eng
text: We show that incorporating spatial dispersal of individuals into a simple
vaccination epidemic model may give rise to a model that exhibits rich dynamical
behavior. Using an SIVS (susceptible-infected-vaccinated-susceptible) model as
a basis, we describe the spread of an infectious disease in a population split
into two regions. In each subpopulation, both forward and backward bifurcations
can occur. This implies that for disconnected regions the two-patch system may
admit several steady states. We consider traveling between the regions and investigate
the impact of spatial dispersal of individuals on the model dynamics. We establish
conditions for the existence of multiple nontrivial steady states in the system,
and we study the structure of the equilibria. The mathematical analysis reveals
an unusually rich dynamical behavior, not normally found in the simple epidemic
models. In addition to the disease-free equilibrium, eight endemic equilibria
emerge from backward transcritical and saddle-node bifurcation points, forming
an interesting bifurcation diagram. Stability of steady states, their bifurcations,
and the global dynamics are investigated with analytical tools, numerical simulations,
and rigorous set-oriented numerical computations.
acknowledgement: Institute of Science and Technology Austria, Am Campus 1, 3400 Klosterneuburg,
Austria (pawel.pilarczyk@ist.ac.at). This author’s work was partially supported
by the People Programme (Marie Curie Actions) of the European Union’s Seventh Framework
Programme (FP7/2007-2013) under REA grant agreement 622033, by Fundo Europeu de
Desenvolvimento Regional (FEDER) through COMPETE—Programa Operacional Factores de
Competitividade (POFC), by the Portuguese national funds through Funda ̧caoparaaCiˆencia
e a Tecnologia (FCT) in the framework of the research project FCOMP-01-0124-FEDER-010645
(ref. FCT PTDC/MAT/098871/2008), and by European Research Council through StG 259559
in the framework of the EPIDELAY project.
article_processing_charge: No
article_type: original
author:
- first_name: Diána
full_name: Knipl, Diána
last_name: Knipl
- first_name: Pawel
full_name: Pilarczyk, Pawel
id: 3768D56A-F248-11E8-B48F-1D18A9856A87
last_name: Pilarczyk
- first_name: Gergely
full_name: Röst, Gergely
last_name: Röst
citation:
ama: Knipl D, Pilarczyk P, Röst G. Rich bifurcation structure in a two patch vaccination
model. SIAM Journal on Applied Dynamical Systems. 2015;14(2):980-1017.
doi:10.1137/140993934
apa: Knipl, D., Pilarczyk, P., & Röst, G. (2015). Rich bifurcation structure
in a two patch vaccination model. SIAM Journal on Applied Dynamical Systems.
Society for Industrial and Applied Mathematics . https://doi.org/10.1137/140993934
chicago: Knipl, Diána, Pawel Pilarczyk, and Gergely Röst. “Rich Bifurcation Structure
in a Two Patch Vaccination Model.” SIAM Journal on Applied Dynamical Systems.
Society for Industrial and Applied Mathematics , 2015. https://doi.org/10.1137/140993934.
ieee: D. Knipl, P. Pilarczyk, and G. Röst, “Rich bifurcation structure in a two
patch vaccination model,” SIAM Journal on Applied Dynamical Systems, vol.
14, no. 2. Society for Industrial and Applied Mathematics , pp. 980–1017, 2015.
ista: Knipl D, Pilarczyk P, Röst G. 2015. Rich bifurcation structure in a two patch
vaccination model. SIAM Journal on Applied Dynamical Systems. 14(2), 980–1017.
mla: Knipl, Diána, et al. “Rich Bifurcation Structure in a Two Patch Vaccination
Model.” SIAM Journal on Applied Dynamical Systems, vol. 14, no. 2, Society
for Industrial and Applied Mathematics , 2015, pp. 980–1017, doi:10.1137/140993934.
short: D. Knipl, P. Pilarczyk, G. Röst, SIAM Journal on Applied Dynamical Systems
14 (2015) 980–1017.
date_created: 2018-12-11T11:52:42Z
date_published: 2015-01-01T00:00:00Z
date_updated: 2021-01-12T06:51:34Z
day: '01'
ddc:
- '510'
department:
- _id: HeEd
doi: 10.1137/140993934
ec_funded: 1
intvolume: ' 14'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://discovery.ucl.ac.uk/1473750/1/99393.pdf
month: '01'
oa: 1
oa_version: Published Version
page: 980 - 1017
project:
- _id: 255F06BE-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '622033'
name: Persistent Homology - Images, Data and Maps
publication: SIAM Journal on Applied Dynamical Systems
publication_identifier:
eissn:
- 1536-0040
publication_status: published
publisher: 'Society for Industrial and Applied Mathematics '
publist_id: '5616'
quality_controlled: '1'
scopus_import: 1
status: public
title: Rich bifurcation structure in a two patch vaccination model
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 14
year: '2015'
...
---
_id: '1558'
abstract:
- lang: eng
text: CyclophilinAis a conserved peptidyl-prolyl cis-trans isomerase (PPIase) best
known as the cellular receptor of the immunosuppressant cyclosporine A. Despite
significant effort, evidence of developmental functions of cyclophilin A in non-plant
systems has remained obscure. Mutations in a tomato (Solanum lycopersicum) cyclophilin
A ortholog, DIAGEOTROPICA (DGT), have been shown to abolish the organogenesis
of lateral roots; however, a mechanistic explanation of the phenotype is lacking.
Here, we show that the dgt mutant lacks auxin maxima relevant to priming and specification
of lateral root founder cells. DGT is expressed in shoot and root, and localizes
to both the nucleus and cytoplasm during lateral root organogenesis. Mutation
of ENTIRE/ IAA9, a member of the auxin-responsive Aux/IAA protein family of transcriptional
repressors, partially restores the inability of dgt to initiate lateral root primordia
but not the primordia outgrowth. By comparison, grafting of a wild-type scion
restores the process of lateral root formation, consistent with participation
of a mobile signal. Antibodies do not detect movement of the DGT protein into
the dgt rootstock; however, experiments with radiolabeled auxin and an auxin-specific
microelectrode demonstrate abnormal auxin fluxes. Functional studies of DGT in
heterologous yeast and tobacco-leaf auxin-transport systems demonstrate that DGT
negatively regulates PIN-FORMED (PIN) auxin efflux transporters by affecting their
plasma membrane localization. Studies in tomato support complex effects of the
dgt mutation on PIN expression level, expression domain and plasma membrane localization.
Our data demonstrate that DGT regulates auxin transport in lateral root formation.
author:
- first_name: Maria
full_name: Ivanchenko, Maria
last_name: Ivanchenko
- first_name: Jinsheng
full_name: Zhu, Jinsheng
last_name: Zhu
- first_name: Bangjun
full_name: Wang, Bangjun
last_name: Wang
- first_name: Eva
full_name: Medvecka, Eva
id: 298814E2-F248-11E8-B48F-1D18A9856A87
last_name: Medvecka
- first_name: Yunlong
full_name: Du, Yunlong
last_name: Du
- first_name: Elisa
full_name: Azzarello, Elisa
last_name: Azzarello
- first_name: Stefano
full_name: Mancuso, Stefano
last_name: Mancuso
- first_name: Molly
full_name: Megraw, Molly
last_name: Megraw
- first_name: Sergei
full_name: Filichkin, Sergei
last_name: Filichkin
- first_name: Joseph
full_name: Dubrovsky, Joseph
last_name: Dubrovsky
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Markus
full_name: Geisler, Markus
last_name: Geisler
citation:
ama: Ivanchenko M, Zhu J, Wang B, et al. The cyclophilin a DIAGEOTROPICA gene affects
auxin transport in both root and shoot to control lateral root formation. Development.
2015;142(4):712-721. doi:10.1242/dev.113225
apa: Ivanchenko, M., Zhu, J., Wang, B., Medvecka, E., Du, Y., Azzarello, E., … Geisler,
M. (2015). The cyclophilin a DIAGEOTROPICA gene affects auxin transport in both
root and shoot to control lateral root formation. Development. Company
of Biologists. https://doi.org/10.1242/dev.113225
chicago: Ivanchenko, Maria, Jinsheng Zhu, Bangjun Wang, Eva Medvecka, Yunlong Du,
Elisa Azzarello, Stefano Mancuso, et al. “The Cyclophilin a DIAGEOTROPICA Gene
Affects Auxin Transport in Both Root and Shoot to Control Lateral Root Formation.”
Development. Company of Biologists, 2015. https://doi.org/10.1242/dev.113225.
ieee: M. Ivanchenko et al., “The cyclophilin a DIAGEOTROPICA gene affects
auxin transport in both root and shoot to control lateral root formation,” Development,
vol. 142, no. 4. Company of Biologists, pp. 712–721, 2015.
ista: Ivanchenko M, Zhu J, Wang B, Medvecka E, Du Y, Azzarello E, Mancuso S, Megraw
M, Filichkin S, Dubrovsky J, Friml J, Geisler M. 2015. The cyclophilin a DIAGEOTROPICA
gene affects auxin transport in both root and shoot to control lateral root formation.
Development. 142(4), 712–721.
mla: Ivanchenko, Maria, et al. “The Cyclophilin a DIAGEOTROPICA Gene Affects Auxin
Transport in Both Root and Shoot to Control Lateral Root Formation.” Development,
vol. 142, no. 4, Company of Biologists, 2015, pp. 712–21, doi:10.1242/dev.113225.
short: M. Ivanchenko, J. Zhu, B. Wang, E. Medvecka, Y. Du, E. Azzarello, S. Mancuso,
M. Megraw, S. Filichkin, J. Dubrovsky, J. Friml, M. Geisler, Development 142 (2015)
712–721.
date_created: 2018-12-11T11:52:42Z
date_published: 2015-02-15T00:00:00Z
date_updated: 2021-01-12T06:51:35Z
day: '15'
department:
- _id: JiFr
doi: 10.1242/dev.113225
intvolume: ' 142'
issue: '4'
language:
- iso: eng
month: '02'
oa_version: None
page: 712 - 721
publication: Development
publication_status: published
publisher: Company of Biologists
publist_id: '5613'
quality_controlled: '1'
scopus_import: 1
status: public
title: The cyclophilin a DIAGEOTROPICA gene affects auxin transport in both root and
shoot to control lateral root formation
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 142
year: '2015'
...
---
_id: '1557'
abstract:
- lang: eng
text: γ-Aminobutyric acid (GABA)- and glycine-mediated hyperpolarizing inhibition
is associated with a chloride influx that depends on the inwardly directed chloride
electrochemical gradient. In neurons, the extrusion of chloride from the cytosol
primarily depends on the expression of an isoform of potassium-chloride cotransporters
(KCC2s). KCC2 is crucial in the regulation of the inhibitory tone of neural circuits,
including pain processing neural assemblies. Thus we investigated the cellular
distribution of KCC2 in neurons underlying pain processing in the superficial
spinal dorsal horn of rats by using high-resolution immunocytochemical methods.
We demonstrated that perikarya and dendrites widely expressed KCC2, but axon terminals
proved to be negative for KCC2. In single ultrathin sections, silver deposits
labeling KCC2 molecules showed different densities on the surface of dendritic
profiles, some of which were negative for KCC2. In freeze fracture replicas and
tissue sections double stained for the β3-subunit of GABAA receptors and KCC2,
GABAA receptors were revealed on dendritic segments with high and also with low
KCC2 densities. By measuring the distances between spots immunoreactive for gephyrin
(a scaffolding protein of GABAA and glycine receptors) and KCC2 on the surface
of neurokinin 1 (NK1) receptor-immunoreactive dendrites, we found that gephyrin-immunoreactive
spots were located at various distances from KCC2 cotransporters; 5.7 % of them
were recovered in the middle of 4-10-μm-long dendritic segments that were free
of KCC2 immunostaining. The variable local densities of KCC2 may result in variable
postsynaptic potentials evoked by the activation of GABAA and glycine receptors
along the dendrites of spinal neurons.
acknowledgement: "Funded by:\r\nHungarian Academy of Sciences. Grant Number: MTA-TKI
242\r\nHungarian Brain Research Program. Grant Number: KTIA_NAP_13-1-2013-0001\r\nSolution
Oriented Research for Science and Technology from the Japan Science and Technology
Agency Japanese Ministry of Education, Culture, Sports, Science and Technology"
author:
- first_name: Fariba
full_name: Javdani, Fariba
last_name: Javdani
- first_name: Krisztina
full_name: Holló, Krisztina
last_name: Holló
- first_name: Krisztina
full_name: Hegedűs, Krisztina
last_name: Hegedűs
- first_name: Gréta
full_name: Kis, Gréta
last_name: Kis
- first_name: Zoltán
full_name: Hegyi, Zoltán
last_name: Hegyi
- first_name: Klaudia
full_name: Dócs, Klaudia
last_name: Dócs
- first_name: Yu
full_name: Kasugai, Yu
last_name: Kasugai
- first_name: Yugo
full_name: Fukazawa, Yugo
last_name: Fukazawa
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Miklós
full_name: Antal, Miklós
last_name: Antal
citation:
ama: Javdani F, Holló K, Hegedűs K, et al. Differential expression patterns of K+Cl-
cotransporter 2 in neurons within the superficial spinal dorsal horn of rats.
Journal of Comparative Neurology. 2015;523(13):1967-1983. doi:10.1002/cne.23774
apa: Javdani, F., Holló, K., Hegedűs, K., Kis, G., Hegyi, Z., Dócs, K., … Antal,
M. (2015). Differential expression patterns of K+Cl- cotransporter 2 in neurons
within the superficial spinal dorsal horn of rats. Journal of Comparative Neurology.
Wiley-Blackwell. https://doi.org/10.1002/cne.23774
chicago: Javdani, Fariba, Krisztina Holló, Krisztina Hegedűs, Gréta Kis, Zoltán
Hegyi, Klaudia Dócs, Yu Kasugai, Yugo Fukazawa, Ryuichi Shigemoto, and Miklós
Antal. “Differential Expression Patterns of K+Cl- Cotransporter 2 in Neurons within
the Superficial Spinal Dorsal Horn of Rats.” Journal of Comparative Neurology.
Wiley-Blackwell, 2015. https://doi.org/10.1002/cne.23774.
ieee: F. Javdani et al., “Differential expression patterns of K+Cl- cotransporter
2 in neurons within the superficial spinal dorsal horn of rats,” Journal of
Comparative Neurology, vol. 523, no. 13. Wiley-Blackwell, pp. 1967–1983, 2015.
ista: Javdani F, Holló K, Hegedűs K, Kis G, Hegyi Z, Dócs K, Kasugai Y, Fukazawa
Y, Shigemoto R, Antal M. 2015. Differential expression patterns of K+Cl- cotransporter
2 in neurons within the superficial spinal dorsal horn of rats. Journal of Comparative
Neurology. 523(13), 1967–1983.
mla: Javdani, Fariba, et al. “Differential Expression Patterns of K+Cl- Cotransporter
2 in Neurons within the Superficial Spinal Dorsal Horn of Rats.” Journal of
Comparative Neurology, vol. 523, no. 13, Wiley-Blackwell, 2015, pp. 1967–83,
doi:10.1002/cne.23774.
short: F. Javdani, K. Holló, K. Hegedűs, G. Kis, Z. Hegyi, K. Dócs, Y. Kasugai,
Y. Fukazawa, R. Shigemoto, M. Antal, Journal of Comparative Neurology 523 (2015)
1967–1983.
date_created: 2018-12-11T11:52:42Z
date_published: 2015-09-01T00:00:00Z
date_updated: 2021-01-12T06:51:35Z
day: '01'
department:
- _id: RySh
doi: 10.1002/cne.23774
intvolume: ' 523'
issue: '13'
language:
- iso: eng
month: '09'
oa_version: None
page: 1967 - 1983
publication: Journal of Comparative Neurology
publication_status: published
publisher: Wiley-Blackwell
publist_id: '5614'
quality_controlled: '1'
scopus_import: 1
status: public
title: Differential expression patterns of K+Cl- cotransporter 2 in neurons within
the superficial spinal dorsal horn of rats
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 523
year: '2015'
...
---
_id: '1559'
abstract:
- lang: eng
text: 'There are deep, yet largely unexplored, connections between computer science
and biology. Both disciplines examine how information proliferates in time and
space. Central results in computer science describe the complexity of algorithms
that solve certain classes of problems. An algorithm is deemed efficient if it
can solve a problem in polynomial time, which means the running time of the algorithm
is a polynomial function of the length of the input. There are classes of harder
problems for which the fastest possible algorithm requires exponential time. Another
criterion is the space requirement of the algorithm. There is a crucial distinction
between algorithms that can find a solution, verify a solution, or list several
distinct solutions in given time and space. The complexity hierarchy that is generated
in this way is the foundation of theoretical computer science. Precise complexity
results can be notoriously difficult. The famous question whether polynomial time
equals nondeterministic polynomial time (i.e., P = NP) is one of the hardest open
problems in computer science and all of mathematics. Here, we consider simple
processes of ecological and evolutionary spatial dynamics. The basic question
is: What is the probability that a new invader (or a new mutant)will take over
a resident population?We derive precise complexity results for a variety of scenarios.
We therefore show that some fundamental questions in this area cannot be answered
by simple equations (assuming that P is not equal to NP).'
author:
- first_name: Rasmus
full_name: Ibsen-Jensen, Rasmus
id: 3B699956-F248-11E8-B48F-1D18A9856A87
last_name: Ibsen-Jensen
orcid: 0000-0003-4783-0389
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Martin
full_name: Nowak, Martin
last_name: Nowak
citation:
ama: Ibsen-Jensen R, Chatterjee K, Nowak M. Computational complexity of ecological
and evolutionary spatial dynamics. PNAS. 2015;112(51):15636-15641. doi:10.1073/pnas.1511366112
apa: Ibsen-Jensen, R., Chatterjee, K., & Nowak, M. (2015). Computational complexity
of ecological and evolutionary spatial dynamics. PNAS. National Academy
of Sciences. https://doi.org/10.1073/pnas.1511366112
chicago: Ibsen-Jensen, Rasmus, Krishnendu Chatterjee, and Martin Nowak. “Computational
Complexity of Ecological and Evolutionary Spatial Dynamics.” PNAS. National
Academy of Sciences, 2015. https://doi.org/10.1073/pnas.1511366112.
ieee: R. Ibsen-Jensen, K. Chatterjee, and M. Nowak, “Computational complexity of
ecological and evolutionary spatial dynamics,” PNAS, vol. 112, no. 51.
National Academy of Sciences, pp. 15636–15641, 2015.
ista: Ibsen-Jensen R, Chatterjee K, Nowak M. 2015. Computational complexity of ecological
and evolutionary spatial dynamics. PNAS. 112(51), 15636–15641.
mla: Ibsen-Jensen, Rasmus, et al. “Computational Complexity of Ecological and Evolutionary
Spatial Dynamics.” PNAS, vol. 112, no. 51, National Academy of Sciences,
2015, pp. 15636–41, doi:10.1073/pnas.1511366112.
short: R. Ibsen-Jensen, K. Chatterjee, M. Nowak, PNAS 112 (2015) 15636–15641.
date_created: 2018-12-11T11:52:43Z
date_published: 2015-12-22T00:00:00Z
date_updated: 2021-01-12T06:51:36Z
day: '22'
department:
- _id: KrCh
doi: 10.1073/pnas.1511366112
external_id:
pmid:
- '26644569'
intvolume: ' 112'
issue: '51'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697423/
month: '12'
oa: 1
oa_version: Submitted Version
page: 15636 - 15641
pmid: 1
publication: PNAS
publication_status: published
publisher: National Academy of Sciences
publist_id: '5612'
quality_controlled: '1'
scopus_import: 1
status: public
title: Computational complexity of ecological and evolutionary spatial dynamics
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 112
year: '2015'
...
---
_id: '1561'
abstract:
- lang: eng
text: Replication-deficient recombinant adenoviruses are potent vectors for the
efficient transient expression of exogenous genes in resting immune cells. However,
most leukocytes are refractory to efficient adenoviral transduction as they lack
expression of the coxsackie/adenovirus receptor (CAR). To circumvent this obstacle,
we generated the R26/CAG-CARΔ1StopF (where R26 is ROSA26 and CAG is CMV early
enhancer/chicken β actin promoter) knock-in mouse line. This strain allows monitoring
of in situ Cre recombinase activity through expression of CARΔ1. Simultaneously,
CARΔ1 expression permits selective and highly efficient adenoviral transduction
of immune cell populations, such as mast cells or T cells, directly ex vivo in
bulk cultures without prior cell purification or activation. Furthermore, we show
that CARΔ1 expression dramatically improves adenoviral infection of in vitro differentiated
conventional and plasmacytoid dendritic cells (DCs), basophils, mast cells, as
well as Hoxb8-immortalized hematopoietic progenitor cells. This novel dual function
mouse strain will hence be a valuable tool to rapidly dissect the function of
specific genes in leukocyte physiology.
author:
- first_name: Klaus
full_name: Heger, Klaus
last_name: Heger
- first_name: Maike
full_name: Kober, Maike
last_name: Kober
- first_name: David
full_name: Rieß, David
last_name: Rieß
- first_name: Christoph
full_name: Drees, Christoph
last_name: Drees
- first_name: Ingrid
full_name: De Vries, Ingrid
id: 4C7D837E-F248-11E8-B48F-1D18A9856A87
last_name: De Vries
- first_name: Arianna
full_name: Bertossi, Arianna
last_name: Bertossi
- first_name: Axel
full_name: Roers, Axel
last_name: Roers
- first_name: Michael K
full_name: Sixt, Michael K
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
- first_name: Marc
full_name: Schmidt Supprian, Marc
last_name: Schmidt Supprian
citation:
ama: Heger K, Kober M, Rieß D, et al. A novel Cre recombinase reporter mouse strain
facilitates selective and efficient infection of primary immune cells with adenoviral
vectors. European Journal of Immunology. 2015;45(6):1614-1620. doi:10.1002/eji.201545457
apa: Heger, K., Kober, M., Rieß, D., Drees, C., de Vries, I., Bertossi, A., … Schmidt
Supprian, M. (2015). A novel Cre recombinase reporter mouse strain facilitates
selective and efficient infection of primary immune cells with adenoviral vectors.
European Journal of Immunology. Wiley. https://doi.org/10.1002/eji.201545457
chicago: Heger, Klaus, Maike Kober, David Rieß, Christoph Drees, Ingrid de Vries,
Arianna Bertossi, Axel Roers, Michael K Sixt, and Marc Schmidt Supprian. “A Novel
Cre Recombinase Reporter Mouse Strain Facilitates Selective and Efficient Infection
of Primary Immune Cells with Adenoviral Vectors.” European Journal of Immunology.
Wiley, 2015. https://doi.org/10.1002/eji.201545457.
ieee: K. Heger et al., “A novel Cre recombinase reporter mouse strain facilitates
selective and efficient infection of primary immune cells with adenoviral vectors,”
European Journal of Immunology, vol. 45, no. 6. Wiley, pp. 1614–1620, 2015.
ista: Heger K, Kober M, Rieß D, Drees C, de Vries I, Bertossi A, Roers A, Sixt MK,
Schmidt Supprian M. 2015. A novel Cre recombinase reporter mouse strain facilitates
selective and efficient infection of primary immune cells with adenoviral vectors.
European Journal of Immunology. 45(6), 1614–1620.
mla: Heger, Klaus, et al. “A Novel Cre Recombinase Reporter Mouse Strain Facilitates
Selective and Efficient Infection of Primary Immune Cells with Adenoviral Vectors.”
European Journal of Immunology, vol. 45, no. 6, Wiley, 2015, pp. 1614–20,
doi:10.1002/eji.201545457.
short: K. Heger, M. Kober, D. Rieß, C. Drees, I. de Vries, A. Bertossi, A. Roers,
M.K. Sixt, M. Schmidt Supprian, European Journal of Immunology 45 (2015) 1614–1620.
date_created: 2018-12-11T11:52:44Z
date_published: 2015-06-01T00:00:00Z
date_updated: 2021-01-12T06:51:36Z
day: '01'
department:
- _id: MiSi
doi: 10.1002/eji.201545457
intvolume: ' 45'
issue: '6'
language:
- iso: eng
month: '06'
oa_version: None
page: 1614 - 1620
publication: European Journal of Immunology
publication_status: published
publisher: Wiley
publist_id: '5610'
quality_controlled: '1'
scopus_import: 1
status: public
title: A novel Cre recombinase reporter mouse strain facilitates selective and efficient
infection of primary immune cells with adenoviral vectors
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 45
year: '2015'
...
---
_id: '1554'
abstract:
- lang: eng
text: The visualization of hormonal signaling input and output is key to understanding
how multicellular development is regulated. The plant signaling molecule auxin
triggers many growth and developmental responses, but current tools lack the sensitivity
or precision to visualize these. We developed a set of fluorescent reporters that
allow sensitive and semiquantitative readout of auxin responses at cellular resolution
in Arabidopsis thaliana. These generic tools are suitable for any transformable
plant species.
author:
- first_name: Cheyang
full_name: Liao, Cheyang
last_name: Liao
- first_name: Wouter
full_name: Smet, Wouter
last_name: Smet
- first_name: Géraldine
full_name: Brunoud, Géraldine
last_name: Brunoud
- first_name: Saiko
full_name: Yoshida, Saiko
id: 2E46069C-F248-11E8-B48F-1D18A9856A87
last_name: Yoshida
- first_name: Teva
full_name: Vernoux, Teva
last_name: Vernoux
- first_name: Dolf
full_name: Weijers, Dolf
last_name: Weijers
citation:
ama: Liao C, Smet W, Brunoud G, Yoshida S, Vernoux T, Weijers D. Reporters for sensitive
and quantitative measurement of auxin response. Nature Methods. 2015;12(3):207-210.
doi:10.1038/nmeth.3279
apa: Liao, C., Smet, W., Brunoud, G., Yoshida, S., Vernoux, T., & Weijers, D.
(2015). Reporters for sensitive and quantitative measurement of auxin response.
Nature Methods. Nature Publishing Group. https://doi.org/10.1038/nmeth.3279
chicago: Liao, Cheyang, Wouter Smet, Géraldine Brunoud, Saiko Yoshida, Teva Vernoux,
and Dolf Weijers. “Reporters for Sensitive and Quantitative Measurement of Auxin
Response.” Nature Methods. Nature Publishing Group, 2015. https://doi.org/10.1038/nmeth.3279.
ieee: C. Liao, W. Smet, G. Brunoud, S. Yoshida, T. Vernoux, and D. Weijers, “Reporters
for sensitive and quantitative measurement of auxin response,” Nature Methods,
vol. 12, no. 3. Nature Publishing Group, pp. 207–210, 2015.
ista: Liao C, Smet W, Brunoud G, Yoshida S, Vernoux T, Weijers D. 2015. Reporters
for sensitive and quantitative measurement of auxin response. Nature Methods.
12(3), 207–210.
mla: Liao, Cheyang, et al. “Reporters for Sensitive and Quantitative Measurement
of Auxin Response.” Nature Methods, vol. 12, no. 3, Nature Publishing Group,
2015, pp. 207–10, doi:10.1038/nmeth.3279.
short: C. Liao, W. Smet, G. Brunoud, S. Yoshida, T. Vernoux, D. Weijers, Nature
Methods 12 (2015) 207–210.
date_created: 2018-12-11T11:52:41Z
date_published: 2015-02-26T00:00:00Z
date_updated: 2021-01-12T06:51:34Z
day: '26'
department:
- _id: JiFr
doi: 10.1038/nmeth.3279
external_id:
pmid:
- '25643149'
intvolume: ' 12'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344836/
month: '02'
oa: 1
oa_version: Submitted Version
page: 207 - 210
pmid: 1
publication: Nature Methods
publication_status: published
publisher: Nature Publishing Group
publist_id: '5617'
quality_controlled: '1'
scopus_import: 1
status: public
title: Reporters for sensitive and quantitative measurement of auxin response
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 12
year: '2015'
...
---
_id: '1560'
abstract:
- lang: eng
text: Stromal cells in the subcapsular sinus of the lymph node 'decide' which cells
and molecules are allowed access to the deeper parenchyma. The glycoprotein PLVAP
is a crucial component of this selector function.
author:
- first_name: Miroslav
full_name: Hons, Miroslav
id: 4167FE56-F248-11E8-B48F-1D18A9856A87
last_name: Hons
orcid: 0000-0002-6625-3348
- first_name: Michael K
full_name: Sixt, Michael K
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
citation:
ama: Hons M, Sixt MK. The lymph node filter revealed. Nature Immunology.
2015;16(4):338-340. doi:10.1038/ni.3126
apa: Hons, M., & Sixt, M. K. (2015). The lymph node filter revealed. Nature
Immunology. Nature Publishing Group. https://doi.org/10.1038/ni.3126
chicago: Hons, Miroslav, and Michael K Sixt. “The Lymph Node Filter Revealed.” Nature
Immunology. Nature Publishing Group, 2015. https://doi.org/10.1038/ni.3126.
ieee: M. Hons and M. K. Sixt, “The lymph node filter revealed,” Nature Immunology,
vol. 16, no. 4. Nature Publishing Group, pp. 338–340, 2015.
ista: Hons M, Sixt MK. 2015. The lymph node filter revealed. Nature Immunology.
16(4), 338–340.
mla: Hons, Miroslav, and Michael K. Sixt. “The Lymph Node Filter Revealed.” Nature
Immunology, vol. 16, no. 4, Nature Publishing Group, 2015, pp. 338–40, doi:10.1038/ni.3126.
short: M. Hons, M.K. Sixt, Nature Immunology 16 (2015) 338–340.
date_created: 2018-12-11T11:52:43Z
date_published: 2015-03-19T00:00:00Z
date_updated: 2021-01-12T06:51:36Z
day: '19'
department:
- _id: MiSi
doi: 10.1038/ni.3126
intvolume: ' 16'
issue: '4'
language:
- iso: eng
month: '03'
oa_version: None
page: 338 - 340
publication: Nature Immunology
publication_status: published
publisher: Nature Publishing Group
publist_id: '5611'
quality_controlled: '1'
scopus_import: 1
status: public
title: The lymph node filter revealed
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 16
year: '2015'
...
---
_id: '1565'
abstract:
- lang: eng
text: Leptin is an adipokine produced by the adipose tissue regulating body weight
through its appetite-suppressing effect. Besides being expressed in the hypothalamus
and hippocampus, leptin receptors (ObRs) are also present in chromaffin cells
of the adrenal medulla. In the present study, we report the effect of leptin on
mouse chromaffin cell (MCC) functionality, focusing on cell excitability and catecholamine
secretion. Acute application of leptin (1 nm) on spontaneously firing MCCs caused
a slowly developing membrane hyperpolarization followed by complete blockade of
action potential (AP) firing. This inhibitory effect at rest was abolished by
the BK channel blocker paxilline (1 μm), suggesting the involvement of BK potassium
channels. Single-channel recordings in 'perforated microvesicles' confirmed that
leptin increased BK channel open probability without altering its unitary conductance.
BK channel up-regulation was associated with the phosphoinositide 3-kinase (PI3K)
signalling cascade because the PI3K specific inhibitor wortmannin (100 nm) fully
prevented BK current increase. We also tested the effect of leptin on evoked AP
firing and Ca2+-driven exocytosis. Although leptin preserves well-adapted AP trains
of lower frequency, APs are broader and depolarization-evoked exocytosis is increased
as a result of the larger size of the ready-releasable pool and higher frequency
of vesicle release. The kinetics and quantal size of single secretory events remained
unaltered. Leptin had no effect on firing and secretion in db-/db- mice lacking
the ObR gene, confirming its specificity. In conclusion, leptin exhibits a dual
action on MCC activity. It dampens AP firing at rest but preserves AP firing and
increases catecholamine secretion during sustained stimulation, highlighting the
importance of the adipo-adrenal axis in the leptin-mediated increase of sympathetic
tone and catecholamine release.
acknowledgement: "This work was supported by the Compagnia di San Paolo Foundation
‘Neuroscience Program’ to VC and ‘Progetto di Ateneo 2011-13’ to EC.\r\nWe thank
Dr Claudio Franchino for cell preparation and for providing excellent technical
support."
author:
- first_name: Daniela
full_name: Gavello, Daniela
last_name: Gavello
- first_name: David H
full_name: Vandael, David H
id: 3AE48E0A-F248-11E8-B48F-1D18A9856A87
last_name: Vandael
orcid: 0000-0001-7577-1676
- first_name: Sara
full_name: Gosso, Sara
last_name: Gosso
- first_name: Emilio
full_name: Carbone, Emilio
last_name: Carbone
- first_name: Valentina
full_name: Carabelli, Valentina
last_name: Carabelli
citation:
ama: Gavello D, Vandael DH, Gosso S, Carbone E, Carabelli V. Dual action of leptin
on rest-firing and stimulated catecholamine release via phosphoinositide 3-kinase-riven
BK channel up-regulation in mouse chromaffin cells. Journal of Physiology.
2015;593(22):4835-4853. doi:10.1113/JP271078
apa: Gavello, D., Vandael, D. H., Gosso, S., Carbone, E., & Carabelli, V. (2015).
Dual action of leptin on rest-firing and stimulated catecholamine release via
phosphoinositide 3-kinase-riven BK channel up-regulation in mouse chromaffin cells.
Journal of Physiology. Wiley-Blackwell. https://doi.org/10.1113/JP271078
chicago: Gavello, Daniela, David H Vandael, Sara Gosso, Emilio Carbone, and Valentina
Carabelli. “Dual Action of Leptin on Rest-Firing and Stimulated Catecholamine
Release via Phosphoinositide 3-Kinase-Riven BK Channel up-Regulation in Mouse
Chromaffin Cells.” Journal of Physiology. Wiley-Blackwell, 2015. https://doi.org/10.1113/JP271078.
ieee: D. Gavello, D. H. Vandael, S. Gosso, E. Carbone, and V. Carabelli, “Dual action
of leptin on rest-firing and stimulated catecholamine release via phosphoinositide
3-kinase-riven BK channel up-regulation in mouse chromaffin cells,” Journal
of Physiology, vol. 593, no. 22. Wiley-Blackwell, pp. 4835–4853, 2015.
ista: Gavello D, Vandael DH, Gosso S, Carbone E, Carabelli V. 2015. Dual action
of leptin on rest-firing and stimulated catecholamine release via phosphoinositide
3-kinase-riven BK channel up-regulation in mouse chromaffin cells. Journal of
Physiology. 593(22), 4835–4853.
mla: Gavello, Daniela, et al. “Dual Action of Leptin on Rest-Firing and Stimulated
Catecholamine Release via Phosphoinositide 3-Kinase-Riven BK Channel up-Regulation
in Mouse Chromaffin Cells.” Journal of Physiology, vol. 593, no. 22, Wiley-Blackwell,
2015, pp. 4835–53, doi:10.1113/JP271078.
short: D. Gavello, D.H. Vandael, S. Gosso, E. Carbone, V. Carabelli, Journal of
Physiology 593 (2015) 4835–4853.
date_created: 2018-12-11T11:52:45Z
date_published: 2015-11-15T00:00:00Z
date_updated: 2021-01-12T06:51:38Z
day: '15'
department:
- _id: PeJo
doi: 10.1113/JP271078
external_id:
pmid:
- '26282459'
intvolume: ' 593'
issue: '22'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650409/
month: '11'
oa: 1
oa_version: Submitted Version
page: 4835 - 4853
pmid: 1
publication: Journal of Physiology
publication_status: published
publisher: Wiley-Blackwell
publist_id: '5606'
quality_controlled: '1'
scopus_import: 1
status: public
title: Dual action of leptin on rest-firing and stimulated catecholamine release via
phosphoinositide 3-kinase-riven BK channel up-regulation in mouse chromaffin cells
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 593
year: '2015'
...
---
_id: '1562'
abstract:
- lang: eng
text: The plant hormone auxin is a key regulator of plant growth and development.
Auxin levels are sensed and interpreted by distinct receptor systems that activate
a broad range of cellular responses. The Auxin-Binding Protein1 (ABP1) that has
been identified based on its ability to bind auxin with high affinity is a prime
candidate for the extracellular receptor responsible for mediating a range of
auxin effects, in particular, the fast non-transcriptional ones. Contradictory
genetic studies suggested prominent or no importance of ABP1 in many developmental
processes. However, how crucial the role of auxin binding to ABP1 is for its functions
has not been addressed. Here, we show that the auxin-binding pocket of ABP1 is
essential for its gain-of-function cellular and developmental roles. In total,
16 different abp1 mutants were prepared that possessed substitutions in the metal
core or in the hydrophobic amino acids of the auxin-binding pocket as well as
neutral mutations. Their analysis revealed that an intact auxin-binding pocket
is a prerequisite for ABP1 to activate downstream components of the ABP1 signalling
pathway, such as Rho of Plants (ROPs) and to mediate the clathrin association
with membranes for endocytosis regulation. In planta analyses demonstrated the
importance of the auxin binding pocket for all known ABP1-mediated postembryonic
developmental processes, including morphology of leaf epidermal cells, root growth
and root meristem activity, and vascular tissue differentiation. Taken together,
these findings suggest that auxin binding to ABP1 is central to its function,
supporting the role of ABP1 as auxin receptor.
acknowledgement: This work was supported by ERC Independent Research grant (ERC-2011-StG-
20101109-PSDP to JF); the European Social Fund and the state budget of the Czech
Republic [the project ‘Employment of Newly Graduated Doctors of Science for Scientific
Excellence’ (CZ.1.07/2.3.00/30.0009) to TN]; the Czech Science Foundation (GACR)
[project 13-40637S to JF].
article_type: original
author:
- first_name: Peter
full_name: Grones, Peter
id: 399876EC-F248-11E8-B48F-1D18A9856A87
last_name: Grones
- first_name: Xu
full_name: Chen, Xu
id: 4E5ADCAA-F248-11E8-B48F-1D18A9856A87
last_name: Chen
- first_name: Sibu
full_name: Simon, Sibu
id: 4542EF9A-F248-11E8-B48F-1D18A9856A87
last_name: Simon
orcid: 0000-0002-1998-6741
- first_name: Walter
full_name: Kaufmann, Walter
id: 3F99E422-F248-11E8-B48F-1D18A9856A87
last_name: Kaufmann
orcid: 0000-0001-9735-5315
- first_name: Riet
full_name: De Rycke, Riet
last_name: De Rycke
- first_name: Tomasz
full_name: Nodzyński, Tomasz
last_name: Nodzyński
- first_name: Eva
full_name: Zažímalová, Eva
last_name: Zažímalová
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Grones P, Chen X, Simon S, et al. Auxin-binding pocket of ABP1 is crucial for
its gain-of-function cellular and developmental roles. Journal of Experimental
Botany. 2015;66(16):5055-5065. doi:10.1093/jxb/erv177
apa: Grones, P., Chen, X., Simon, S., Kaufmann, W., De Rycke, R., Nodzyński, T.,
… Friml, J. (2015). Auxin-binding pocket of ABP1 is crucial for its gain-of-function
cellular and developmental roles. Journal of Experimental Botany. Oxford
University Press. https://doi.org/10.1093/jxb/erv177
chicago: Grones, Peter, Xu Chen, Sibu Simon, Walter Kaufmann, Riet De Rycke, Tomasz
Nodzyński, Eva Zažímalová, and Jiří Friml. “Auxin-Binding Pocket of ABP1 Is Crucial
for Its Gain-of-Function Cellular and Developmental Roles.” Journal of Experimental
Botany. Oxford University Press, 2015. https://doi.org/10.1093/jxb/erv177.
ieee: P. Grones et al., “Auxin-binding pocket of ABP1 is crucial for its
gain-of-function cellular and developmental roles,” Journal of Experimental
Botany, vol. 66, no. 16. Oxford University Press, pp. 5055–5065, 2015.
ista: Grones P, Chen X, Simon S, Kaufmann W, De Rycke R, Nodzyński T, Zažímalová
E, Friml J. 2015. Auxin-binding pocket of ABP1 is crucial for its gain-of-function
cellular and developmental roles. Journal of Experimental Botany. 66(16), 5055–5065.
mla: Grones, Peter, et al. “Auxin-Binding Pocket of ABP1 Is Crucial for Its Gain-of-Function
Cellular and Developmental Roles.” Journal of Experimental Botany, vol.
66, no. 16, Oxford University Press, 2015, pp. 5055–65, doi:10.1093/jxb/erv177.
short: P. Grones, X. Chen, S. Simon, W. Kaufmann, R. De Rycke, T. Nodzyński, E.
Zažímalová, J. Friml, Journal of Experimental Botany 66 (2015) 5055–5065.
date_created: 2018-12-11T11:52:44Z
date_published: 2015-08-01T00:00:00Z
date_updated: 2023-02-23T10:04:26Z
day: '01'
department:
- _id: JiFr
- _id: EM-Fac
doi: 10.1093/jxb/erv177
ec_funded: 1
intvolume: ' 66'
issue: '16'
language:
- iso: eng
month: '08'
oa_version: None
page: 5055 - 5065
project:
- _id: 25716A02-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '282300'
name: Polarity and subcellular dynamics in plants
publication: Journal of Experimental Botany
publication_status: published
publisher: Oxford University Press
publist_id: '5609'
quality_controlled: '1'
scopus_import: 1
status: public
title: Auxin-binding pocket of ABP1 is crucial for its gain-of-function cellular and
developmental roles
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 66
year: '2015'
...
---
_id: '1564'
article_number: '145'
author:
- first_name: Matthieu
full_name: Gilson, Matthieu
last_name: Gilson
- first_name: Cristina
full_name: Savin, Cristina
id: 3933349E-F248-11E8-B48F-1D18A9856A87
last_name: Savin
- first_name: Friedemann
full_name: Zenke, Friedemann
last_name: Zenke
citation:
ama: 'Gilson M, Savin C, Zenke F. Editorial: Emergent neural computation from the
interaction of different forms of plasticity. Frontiers in Computational Neuroscience.
2015;9(11). doi:10.3389/fncom.2015.00145'
apa: 'Gilson, M., Savin, C., & Zenke, F. (2015). Editorial: Emergent neural
computation from the interaction of different forms of plasticity. Frontiers
in Computational Neuroscience. Frontiers Research Foundation. https://doi.org/10.3389/fncom.2015.00145'
chicago: 'Gilson, Matthieu, Cristina Savin, and Friedemann Zenke. “Editorial: Emergent
Neural Computation from the Interaction of Different Forms of Plasticity.” Frontiers
in Computational Neuroscience. Frontiers Research Foundation, 2015. https://doi.org/10.3389/fncom.2015.00145.'
ieee: 'M. Gilson, C. Savin, and F. Zenke, “Editorial: Emergent neural computation
from the interaction of different forms of plasticity,” Frontiers in Computational
Neuroscience, vol. 9, no. 11. Frontiers Research Foundation, 2015.'
ista: 'Gilson M, Savin C, Zenke F. 2015. Editorial: Emergent neural computation
from the interaction of different forms of plasticity. Frontiers in Computational
Neuroscience. 9(11), 145.'
mla: 'Gilson, Matthieu, et al. “Editorial: Emergent Neural Computation from the
Interaction of Different Forms of Plasticity.” Frontiers in Computational Neuroscience,
vol. 9, no. 11, 145, Frontiers Research Foundation, 2015, doi:10.3389/fncom.2015.00145.'
short: M. Gilson, C. Savin, F. Zenke, Frontiers in Computational Neuroscience 9
(2015).
date_created: 2018-12-11T11:52:45Z
date_published: 2015-11-30T00:00:00Z
date_updated: 2021-01-12T06:51:37Z
day: '30'
ddc:
- '570'
department:
- _id: GaTk
doi: 10.3389/fncom.2015.00145
ec_funded: 1
file:
- access_level: open_access
checksum: cea73b6d3ef1579f32da10b82f4de4fd
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:12:09Z
date_updated: 2020-07-14T12:45:02Z
file_id: '4927'
file_name: IST-2016-479-v1+1_fncom-09-00145.pdf
file_size: 187038
relation: main_file
file_date_updated: 2020-07-14T12:45:02Z
has_accepted_license: '1'
intvolume: ' 9'
issue: '11'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication: Frontiers in Computational Neuroscience
publication_status: published
publisher: Frontiers Research Foundation
publist_id: '5607'
pubrep_id: '479'
quality_controlled: '1'
scopus_import: 1
status: public
title: 'Editorial: Emergent neural computation from the interaction of different forms
of plasticity'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 9
year: '2015'
...
---
_id: '1568'
abstract:
- lang: eng
text: Aiming at the automatic diagnosis of tumors from narrow band imaging (NBI)
magnifying endoscopy (ME) images of the stomach, we combine methods from image
processing, computational topology, and machine learning to classify patterns
into normal, tubular, vessel. Training the algorithm on a small number of images
of each type, we achieve a high rate of correct classifications. The analysis
of the learning algorithm reveals that a handful of geometric and topological
features are responsible for the overwhelming majority of decisions.
acknowledgement: This research is supported by the project No. 477 of P.G. Demidov
Yaroslavl State University within State Assignment for Research.
author:
- first_name: Olga
full_name: Dunaeva, Olga
last_name: Dunaeva
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Anton
full_name: Lukyanov, Anton
last_name: Lukyanov
- first_name: Michael
full_name: Machin, Michael
last_name: Machin
- first_name: Daria
full_name: Malkova, Daria
last_name: Malkova
citation:
ama: 'Dunaeva O, Edelsbrunner H, Lukyanov A, Machin M, Malkova D. The classification
of endoscopy images with persistent homology. In: Proceedings - 16th International
Symposium on Symbolic and Numeric Algorithms for Scientific Computing. IEEE;
2015:7034731. doi:10.1109/SYNASC.2014.81'
apa: 'Dunaeva, O., Edelsbrunner, H., Lukyanov, A., Machin, M., & Malkova, D.
(2015). The classification of endoscopy images with persistent homology. In Proceedings
- 16th International Symposium on Symbolic and Numeric Algorithms for Scientific
Computing (p. 7034731). Timisoara, Romania: IEEE. https://doi.org/10.1109/SYNASC.2014.81'
chicago: Dunaeva, Olga, Herbert Edelsbrunner, Anton Lukyanov, Michael Machin, and
Daria Malkova. “The Classification of Endoscopy Images with Persistent Homology.”
In Proceedings - 16th International Symposium on Symbolic and Numeric Algorithms
for Scientific Computing, 7034731. IEEE, 2015. https://doi.org/10.1109/SYNASC.2014.81.
ieee: O. Dunaeva, H. Edelsbrunner, A. Lukyanov, M. Machin, and D. Malkova, “The
classification of endoscopy images with persistent homology,” in Proceedings
- 16th International Symposium on Symbolic and Numeric Algorithms for Scientific
Computing, Timisoara, Romania, 2015, p. 7034731.
ista: 'Dunaeva O, Edelsbrunner H, Lukyanov A, Machin M, Malkova D. 2015. The classification
of endoscopy images with persistent homology. Proceedings - 16th International
Symposium on Symbolic and Numeric Algorithms for Scientific Computing. SYNASC:
Symbolic and Numeric Algorithms for Scientific Computing, 7034731.'
mla: Dunaeva, Olga, et al. “The Classification of Endoscopy Images with Persistent
Homology.” Proceedings - 16th International Symposium on Symbolic and Numeric
Algorithms for Scientific Computing, IEEE, 2015, p. 7034731, doi:10.1109/SYNASC.2014.81.
short: O. Dunaeva, H. Edelsbrunner, A. Lukyanov, M. Machin, D. Malkova, in:, Proceedings
- 16th International Symposium on Symbolic and Numeric Algorithms for Scientific
Computing, IEEE, 2015, p. 7034731.
conference:
end_date: 2014-09-25
location: Timisoara, Romania
name: 'SYNASC: Symbolic and Numeric Algorithms for Scientific Computing'
start_date: 2014-09-22
date_created: 2018-12-11T11:52:46Z
date_published: 2015-02-05T00:00:00Z
date_updated: 2023-02-21T16:57:29Z
day: '05'
department:
- _id: HeEd
doi: 10.1109/SYNASC.2014.81
language:
- iso: eng
month: '02'
oa_version: None
page: '7034731'
publication: Proceedings - 16th International Symposium on Symbolic and Numeric Algorithms
for Scientific Computing
publication_status: published
publisher: IEEE
publist_id: '5603'
quality_controlled: '1'
related_material:
record:
- id: '1289'
relation: later_version
status: public
scopus_import: 1
status: public
title: The classification of endoscopy images with persistent homology
type: conference
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
year: '2015'
...
---
_id: '1567'
abstract:
- lang: eng
text: My personal journey to the fascinating world of geometric forms started more
than 30 years ago with the invention of alpha shapes in the plane. It took about
10 years before we generalized the concept to higher dimensions, we produced working
software with a graphics interface for the three-dimensional case. At the same
time, we added homology to the computations. Needless to say that this foreshadowed
the inception of persistent homology, because it suggested the study of filtrations
to capture the scale of a shape or data set. Importantly, this method has fast
algorithms. The arguably most useful result on persistent homology is the stability
of its diagrams under perturbations.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
citation:
ama: 'Edelsbrunner H. Shape, homology, persistence, and stability. In: 23rd International
Symposium. Vol 9411. Springer Nature; 2015.'
apa: 'Edelsbrunner, H. (2015). Shape, homology, persistence, and stability. In 23rd
International Symposium (Vol. 9411). Los Angeles, CA, United States: Springer
Nature.'
chicago: Edelsbrunner, Herbert. “Shape, Homology, Persistence, and Stability.” In
23rd International Symposium, Vol. 9411. Springer Nature, 2015.
ieee: H. Edelsbrunner, “Shape, homology, persistence, and stability,” in 23rd
International Symposium, Los Angeles, CA, United States, 2015, vol. 9411.
ista: 'Edelsbrunner H. 2015. Shape, homology, persistence, and stability. 23rd International
Symposium. GD: Graph Drawing and Network Visualization, LNCS, vol. 9411.'
mla: Edelsbrunner, Herbert. “Shape, Homology, Persistence, and Stability.” 23rd
International Symposium, vol. 9411, Springer Nature, 2015.
short: H. Edelsbrunner, in:, 23rd International Symposium, Springer Nature, 2015.
conference:
end_date: 2015-09-26
location: Los Angeles, CA, United States
name: 'GD: Graph Drawing and Network Visualization'
start_date: 2015-09-24
date_created: 2018-12-11T11:52:46Z
date_published: 2015-01-01T00:00:00Z
date_updated: 2022-01-28T08:25:00Z
day: '01'
department:
- _id: HeEd
intvolume: ' 9411'
language:
- iso: eng
month: '01'
oa_version: None
publication: 23rd International Symposium
publication_status: published
publisher: Springer Nature
publist_id: '5604'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Shape, homology, persistence, and stability
type: conference
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 9411
year: '2015'
...
---
_id: '1563'
abstract:
- lang: eng
text: For a given self-map $f$ of $M$, a closed smooth connected and simply-connected
manifold of dimension $m\geq 4$, we provide an algorithm for estimating the values
of the topological invariant $D^m_r[f]$, which equals the minimal number of $r$-periodic
points in the smooth homotopy class of $f$. Our results are based on the combinatorial
scheme for computing $D^m_r[f]$ introduced by G. Graff and J. Jezierski [J. Fixed
Point Theory Appl. 13 (2013), 63-84]. An open-source implementation of the algorithm
programmed in C++ is publicly available at {\tt http://www.pawelpilarczyk.com/combtop/}.
author:
- first_name: Grzegorz
full_name: Graff, Grzegorz
last_name: Graff
- first_name: Pawel
full_name: Pilarczyk, Pawel
id: 3768D56A-F248-11E8-B48F-1D18A9856A87
last_name: Pilarczyk
citation:
ama: Graff G, Pilarczyk P. An algorithmic approach to estimating the minimal number
of periodic points for smooth self-maps of simply-connected manifolds. Topological
Methods in Nonlinear Analysis. 2015;45(1):273-286. doi:10.12775/TMNA.2015.014
apa: Graff, G., & Pilarczyk, P. (2015). An algorithmic approach to estimating
the minimal number of periodic points for smooth self-maps of simply-connected
manifolds. Topological Methods in Nonlinear Analysis. Juliusz Schauder
Center for Nonlinear Studies. https://doi.org/10.12775/TMNA.2015.014
chicago: Graff, Grzegorz, and Pawel Pilarczyk. “An Algorithmic Approach to Estimating
the Minimal Number of Periodic Points for Smooth Self-Maps of Simply-Connected
Manifolds.” Topological Methods in Nonlinear Analysis. Juliusz Schauder
Center for Nonlinear Studies, 2015. https://doi.org/10.12775/TMNA.2015.014.
ieee: G. Graff and P. Pilarczyk, “An algorithmic approach to estimating the minimal
number of periodic points for smooth self-maps of simply-connected manifolds,”
Topological Methods in Nonlinear Analysis, vol. 45, no. 1. Juliusz Schauder
Center for Nonlinear Studies, pp. 273–286, 2015.
ista: Graff G, Pilarczyk P. 2015. An algorithmic approach to estimating the minimal
number of periodic points for smooth self-maps of simply-connected manifolds.
Topological Methods in Nonlinear Analysis. 45(1), 273–286.
mla: Graff, Grzegorz, and Pawel Pilarczyk. “An Algorithmic Approach to Estimating
the Minimal Number of Periodic Points for Smooth Self-Maps of Simply-Connected
Manifolds.” Topological Methods in Nonlinear Analysis, vol. 45, no. 1,
Juliusz Schauder Center for Nonlinear Studies, 2015, pp. 273–86, doi:10.12775/TMNA.2015.014.
short: G. Graff, P. Pilarczyk, Topological Methods in Nonlinear Analysis 45 (2015)
273–286.
date_created: 2018-12-11T11:52:44Z
date_published: 2015-03-01T00:00:00Z
date_updated: 2021-01-12T06:51:37Z
day: '01'
department:
- _id: HeEd
doi: 10.12775/TMNA.2015.014
intvolume: ' 45'
issue: '1'
language:
- iso: eng
month: '03'
oa_version: None
page: 273 - 286
publication: Topological Methods in Nonlinear Analysis
publication_status: published
publisher: Juliusz Schauder Center for Nonlinear Studies
publist_id: '5608'
quality_controlled: '1'
scopus_import: 1
status: public
title: An algorithmic approach to estimating the minimal number of periodic points
for smooth self-maps of simply-connected manifolds
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 45
year: '2015'
...
---
_id: '1574'
abstract:
- lang: eng
text: Multiple plant developmental processes, such as lateral root development,
depend on auxin distribution patterns that are in part generated by the PIN-formed
family of auxin-efflux transporters. Here we propose that AUXIN RESPONSE FACTOR7
(ARF7) and the ARF7-regulated FOUR LIPS/MYB124 (FLP) transcription factors jointly
form a coherent feed-forward motif that mediates the auxin-responsive PIN3 transcription
in planta to steer the early steps of lateral root formation. This regulatory
mechanism might endow the PIN3 circuitry with a temporal 'memory' of auxin stimuli,
potentially maintaining and enhancing the robustness of the auxin flux directionality
during lateral root development. The cooperative action between canonical auxin
signalling and other transcription factors might constitute a general mechanism
by which transcriptional auxin-sensitivity can be regulated at a tissue-specific
level.
acknowledgement: 'of the European Research Council (project ERC-2011-StG-20101109-PSDP)
(to J.F.), a FEBS long-term fellowship (to P.M.) '
article_number: '8821'
author:
- first_name: Qian
full_name: Chen, Qian
last_name: Chen
- first_name: Yang
full_name: Liu, Yang
last_name: Liu
- first_name: Steven
full_name: Maere, Steven
last_name: Maere
- first_name: Eunkyoung
full_name: Lee, Eunkyoung
last_name: Lee
- first_name: Gert
full_name: Van Isterdael, Gert
last_name: Van Isterdael
- first_name: Zidian
full_name: Xie, Zidian
last_name: Xie
- first_name: Wei
full_name: Xuan, Wei
last_name: Xuan
- first_name: Jessica
full_name: Lucas, Jessica
last_name: Lucas
- first_name: Valya
full_name: Vassileva, Valya
last_name: Vassileva
- first_name: Saeko
full_name: Kitakura, Saeko
last_name: Kitakura
- first_name: Peter
full_name: Marhavy, Peter
id: 3F45B078-F248-11E8-B48F-1D18A9856A87
last_name: Marhavy
orcid: 0000-0001-5227-5741
- first_name: Krzysztof T
full_name: Wabnik, Krzysztof T
id: 4DE369A4-F248-11E8-B48F-1D18A9856A87
last_name: Wabnik
orcid: 0000-0001-7263-0560
- first_name: Niko
full_name: Geldner, Niko
last_name: Geldner
- first_name: Eva
full_name: Benková, Eva
id: 38F4F166-F248-11E8-B48F-1D18A9856A87
last_name: Benková
orcid: 0000-0002-8510-9739
- first_name: Jie
full_name: Le, Jie
last_name: Le
- first_name: Hidehiro
full_name: Fukaki, Hidehiro
last_name: Fukaki
- first_name: Erich
full_name: Grotewold, Erich
last_name: Grotewold
- first_name: Chuanyou
full_name: Li, Chuanyou
last_name: Li
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Fred
full_name: Sack, Fred
last_name: Sack
- first_name: Tom
full_name: Beeckman, Tom
last_name: Beeckman
- first_name: Steffen
full_name: Vanneste, Steffen
last_name: Vanneste
citation:
ama: Chen Q, Liu Y, Maere S, et al. A coherent transcriptional feed-forward motif
model for mediating auxin-sensitive PIN3 expression during lateral root development.
Nature Communications. 2015;6. doi:10.1038/ncomms9821
apa: Chen, Q., Liu, Y., Maere, S., Lee, E., Van Isterdael, G., Xie, Z., … Vanneste,
S. (2015). A coherent transcriptional feed-forward motif model for mediating auxin-sensitive
PIN3 expression during lateral root development. Nature Communications.
Nature Publishing Group. https://doi.org/10.1038/ncomms9821
chicago: Chen, Qian, Yang Liu, Steven Maere, Eunkyoung Lee, Gert Van Isterdael,
Zidian Xie, Wei Xuan, et al. “A Coherent Transcriptional Feed-Forward Motif Model
for Mediating Auxin-Sensitive PIN3 Expression during Lateral Root Development.”
Nature Communications. Nature Publishing Group, 2015. https://doi.org/10.1038/ncomms9821.
ieee: Q. Chen et al., “A coherent transcriptional feed-forward motif model
for mediating auxin-sensitive PIN3 expression during lateral root development,”
Nature Communications, vol. 6. Nature Publishing Group, 2015.
ista: Chen Q, Liu Y, Maere S, Lee E, Van Isterdael G, Xie Z, Xuan W, Lucas J, Vassileva
V, Kitakura S, Marhavý P, Wabnik KT, Geldner N, Benková E, Le J, Fukaki H, Grotewold
E, Li C, Friml J, Sack F, Beeckman T, Vanneste S. 2015. A coherent transcriptional
feed-forward motif model for mediating auxin-sensitive PIN3 expression during
lateral root development. Nature Communications. 6, 8821.
mla: Chen, Qian, et al. “A Coherent Transcriptional Feed-Forward Motif Model for
Mediating Auxin-Sensitive PIN3 Expression during Lateral Root Development.” Nature
Communications, vol. 6, 8821, Nature Publishing Group, 2015, doi:10.1038/ncomms9821.
short: Q. Chen, Y. Liu, S. Maere, E. Lee, G. Van Isterdael, Z. Xie, W. Xuan, J.
Lucas, V. Vassileva, S. Kitakura, P. Marhavý, K.T. Wabnik, N. Geldner, E. Benková,
J. Le, H. Fukaki, E. Grotewold, C. Li, J. Friml, F. Sack, T. Beeckman, S. Vanneste,
Nature Communications 6 (2015).
date_created: 2018-12-11T11:52:48Z
date_published: 2015-11-18T00:00:00Z
date_updated: 2021-01-12T06:51:42Z
day: '18'
ddc:
- '580'
department:
- _id: EvBe
- _id: JiFr
doi: 10.1038/ncomms9821
file:
- access_level: open_access
checksum: 8ff5c108899b548806e1cb7a302fe76d
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:14:32Z
date_updated: 2020-07-14T12:45:02Z
file_id: '5085'
file_name: IST-2016-477-v1+1_ncomms9821.pdf
file_size: 1701815
relation: main_file
file_date_updated: 2020-07-14T12:45:02Z
has_accepted_license: '1'
intvolume: ' 6'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
publication: Nature Communications
publication_status: published
publisher: Nature Publishing Group
publist_id: '5597'
pubrep_id: '477'
quality_controlled: '1'
scopus_import: 1
status: public
title: A coherent transcriptional feed-forward motif model for mediating auxin-sensitive
PIN3 expression during lateral root development
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 6
year: '2015'
...
---
_id: '1575'
abstract:
- lang: eng
text: The immune response relies on the migration of leukocytes and on their ability
to stop in precise anatomical locations to fulfil their task. How leukocyte migration
and function are coordinated is unknown. Here we show that in immature dendritic
cells, which patrol their environment by engulfing extracellular material, cell
migration and antigen capture are antagonistic. This antagonism results from transient
enrichment of myosin IIA at the cell front, which disrupts the back-to-front gradient
of the motor protein, slowing down locomotion but promoting antigen capture. We
further highlight that myosin IIA enrichment at the cell front requires the MHC
class II-associated invariant chain (Ii). Thus, by controlling myosin IIA localization,
Ii imposes on dendritic cells an intermittent antigen capture behaviour that might
facilitate environment patrolling. We propose that the requirement for myosin
II in both cell migration and specific cell functions may provide a general mechanism
for their coordination in time and space.
acknowledgement: M.C. and M.L.H. were supported by fellowships from the Fondation
pour la Recherche Médicale and the Association pour la Recherche contre le Cancer,
respectively. This work was funded by grants from the City of Paris and the European
Research Council to A.-M.L.-D. (Strapacemi 243103), the Association Nationale pour
la Recherche (ANR-09-PIRI-0027-PCVI) and the InnaBiosanté foundation (Micemico)
to A.-M.L.-D., M.P. and R.V., and the DCBIOL Labex from the French Government (ANR-10-IDEX-0001-02-PSL*
and ANR-11-LABX-0043). The super-resolution SIM microscope was funded through an
ERC Advanced Investigator Grant (250367) to Edith Heard (CNRS UMR3215/Inserm U934,
Institut Curie).
article_number: '7526'
author:
- first_name: Mélanie
full_name: Chabaud, Mélanie
last_name: Chabaud
- first_name: Mélina
full_name: Heuzé, Mélina
last_name: Heuzé
- first_name: Marine
full_name: Bretou, Marine
last_name: Bretou
- first_name: Pablo
full_name: Vargas, Pablo
last_name: Vargas
- first_name: Paolo
full_name: Maiuri, Paolo
last_name: Maiuri
- first_name: Paola
full_name: Solanes, Paola
last_name: Solanes
- first_name: Mathieu
full_name: Maurin, Mathieu
last_name: Maurin
- first_name: Emmanuel
full_name: Terriac, Emmanuel
last_name: Terriac
- first_name: Maël
full_name: Le Berre, Maël
last_name: Le Berre
- first_name: Danielle
full_name: Lankar, Danielle
last_name: Lankar
- first_name: Tristan
full_name: Piolot, Tristan
last_name: Piolot
- first_name: Robert
full_name: Adelstein, Robert
last_name: Adelstein
- first_name: Yingfan
full_name: Zhang, Yingfan
last_name: Zhang
- first_name: Michael K
full_name: Sixt, Michael K
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
- first_name: Jordan
full_name: Jacobelli, Jordan
last_name: Jacobelli
- first_name: Olivier
full_name: Bénichou, Olivier
last_name: Bénichou
- first_name: Raphaël
full_name: Voituriez, Raphaël
last_name: Voituriez
- first_name: Matthieu
full_name: Piel, Matthieu
last_name: Piel
- first_name: Ana
full_name: Lennon Duménil, Ana
last_name: Lennon Duménil
citation:
ama: Chabaud M, Heuzé M, Bretou M, et al. Cell migration and antigen capture are
antagonistic processes coupled by myosin II in dendritic cells. Nature Communications.
2015;6. doi:10.1038/ncomms8526
apa: Chabaud, M., Heuzé, M., Bretou, M., Vargas, P., Maiuri, P., Solanes, P., …
Lennon Duménil, A. (2015). Cell migration and antigen capture are antagonistic
processes coupled by myosin II in dendritic cells. Nature Communications.
Nature Publishing Group. https://doi.org/10.1038/ncomms8526
chicago: Chabaud, Mélanie, Mélina Heuzé, Marine Bretou, Pablo Vargas, Paolo Maiuri,
Paola Solanes, Mathieu Maurin, et al. “Cell Migration and Antigen Capture Are
Antagonistic Processes Coupled by Myosin II in Dendritic Cells.” Nature Communications.
Nature Publishing Group, 2015. https://doi.org/10.1038/ncomms8526.
ieee: M. Chabaud et al., “Cell migration and antigen capture are antagonistic
processes coupled by myosin II in dendritic cells,” Nature Communications,
vol. 6. Nature Publishing Group, 2015.
ista: Chabaud M, Heuzé M, Bretou M, Vargas P, Maiuri P, Solanes P, Maurin M, Terriac
E, Le Berre M, Lankar D, Piolot T, Adelstein R, Zhang Y, Sixt MK, Jacobelli J,
Bénichou O, Voituriez R, Piel M, Lennon Duménil A. 2015. Cell migration and antigen
capture are antagonistic processes coupled by myosin II in dendritic cells. Nature
Communications. 6, 7526.
mla: Chabaud, Mélanie, et al. “Cell Migration and Antigen Capture Are Antagonistic
Processes Coupled by Myosin II in Dendritic Cells.” Nature Communications,
vol. 6, 7526, Nature Publishing Group, 2015, doi:10.1038/ncomms8526.
short: M. Chabaud, M. Heuzé, M. Bretou, P. Vargas, P. Maiuri, P. Solanes, M. Maurin,
E. Terriac, M. Le Berre, D. Lankar, T. Piolot, R. Adelstein, Y. Zhang, M.K. Sixt,
J. Jacobelli, O. Bénichou, R. Voituriez, M. Piel, A. Lennon Duménil, Nature Communications
6 (2015).
date_created: 2018-12-11T11:52:48Z
date_published: 2015-06-25T00:00:00Z
date_updated: 2021-01-12T06:51:42Z
day: '25'
ddc:
- '570'
department:
- _id: MiSi
doi: 10.1038/ncomms8526
file:
- access_level: open_access
checksum: bae12e86be2adb28253f890b8bba8315
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:11:58Z
date_updated: 2020-07-14T12:45:02Z
file_id: '4915'
file_name: IST-2016-476-v1+1_ncomms8526.pdf
file_size: 4530215
relation: main_file
file_date_updated: 2020-07-14T12:45:02Z
has_accepted_license: '1'
intvolume: ' 6'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
publication: Nature Communications
publication_status: published
publisher: Nature Publishing Group
publist_id: '5596'
pubrep_id: '476'
quality_controlled: '1'
scopus_import: 1
status: public
title: Cell migration and antigen capture are antagonistic processes coupled by myosin
II in dendritic cells
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 6
year: '2015'
...