---
_id: '981'
abstract:
- lang: eng
  text: The tunability of topological surface states and controllable opening of the
    Dirac gap are of fundamental and practical interest in the field of topological
    materials. In the newly discovered topological crystalline insulators (TCIs),
    theory predicts that the Dirac node is protected by a crystalline symmetry and
    that the surface state electrons can acquire a mass if this symmetry is broken.
    Recent studies have detected signatures of a spontaneously generated Dirac gap
    in TCIs; however, the mechanism of mass formation remains elusive. In this work,
    we present scanning tunnelling microscopy (STM) measurements of the TCI Pb 1â'x
    Sn x Se for a wide range of alloy compositions spanning the topological and non-topological
    regimes. The STM topographies reveal a symmetry-breaking distortion on the surface,
    which imparts mass to the otherwise massless Dirac electrons-a mechanism analogous
    to the long sought-after Higgs mechanism in particle physics. Interestingly, the
    measured Dirac gap decreases on approaching the trivial phase, whereas the magnitude
    of the distortion remains nearly constant. Our data and calculations reveal that
    the penetration depth of Dirac surface states controls the magnitude of the Dirac
    mass. At the limit of the critical composition, the penetration depth is predicted
    to go to infinity, resulting in zero mass, consistent with our measurements. Finally,
    we discover the existence of surface states in the non-topological regime, which
    have the characteristics of gapped, double-branched Dirac fermions and could be
    exploited in realizing superconductivity in these materials.
acknowledgement: We thank R. Buczko, C. Chamon, J. C. Seamus Davis, M. El-Batanouny,
  A. Mesaros, Y. Ran and A. Soumyanarayanan for useful conversations and G. McMahon
  for help with EDS measurements. V.M. gratefully acknowledges funding from the US
  Department of Energy, Scanned Probe Division under Award Number DE-FG02-12ER46880
  for the support of I.Z., Y.O., W.Z. and D.W. for this project. Work at Massachusetts
  Institute of Technology is supported by US Department of Energy, Office of Basic
  Energy Sciences, Division of Materials Sciences and Engineering under Award DE-SC0010526
  (L.F.), and NSF-DMR-1104498 (M.S.). H.L. acknowledges the Singapore National Research
  Foundation for support under NRF Award No. NRF-NRFF2013-03. Y.O. was partly supported
  by JSPS KAKENHI Grant Numbers 26707016 and 00707656. The work at Northeastern University
  is supported by the US Department of Energy grant number DE-FG02-07ER46352, and
  benefited from Northeastern University’s Advanced Scientific Computation Center
  (ASCC), theory support at the Advanced Light Source, Berkeley and the allocation
  of supercomputer time at the NERSC through DOE grant number DE-AC02-05CH11231. Work
  at Princeton University is supported by the US National Science Foundation Grant,
  NSF-DMR-1006492. F.C. acknowledges the support provided by MOST-Taiwan under project
  number NSC-102-2119-M-002-004.
author:
- first_name: Ilija
  full_name: Zeljkovic, Ilija
  last_name: Zeljkovic
- first_name: Yoshinori
  full_name: Okada, Yoshinori
  last_name: Okada
- first_name: Maksym
  full_name: Maksym Serbyn
  id: 47809E7E-F248-11E8-B48F-1D18A9856A87
  last_name: Serbyn
  orcid: 0000-0002-2399-5827
- first_name: Raman
  full_name: Sankar, Raman
  last_name: Sankar
- first_name: Daniel
  full_name: Walkup, Daniel
  last_name: Walkup
- first_name: Wenwen
  full_name: Zhou, Wenwen
  last_name: Zhou
- first_name: Junwei
  full_name: Liu, Junwei
  last_name: Liu
- first_name: Guoqing
  full_name: Chang, Guoqing
  last_name: Chang
- first_name: Yungjui
  full_name: Wang, Yungjui
  last_name: Wang
- first_name: Md
  full_name: Hasan, Md Z
  last_name: Hasan
- first_name: Fangcheng
  full_name: Chou, Fangcheng
  last_name: Chou
- first_name: Hsin
  full_name: Lin, Hsin
  last_name: Lin
- first_name: Arun
  full_name: Bansil, Arun
  last_name: Bansil
- first_name: Liang
  full_name: Fu, Liang
  last_name: Fu
- first_name: Vidya
  full_name: Madhavan, Vidya
  last_name: Madhavan
citation:
  ama: Zeljkovic I, Okada Y, Serbyn M, et al. Dirac mass generation from crystal symmetry
    breaking on the surfaces of topological crystalline insulators. <i>Nature Materials</i>.
    2015;14(3):318-324. doi:<a href="https://doi.org/10.1038/nmat4215">10.1038/nmat4215</a>
  apa: Zeljkovic, I., Okada, Y., Serbyn, M., Sankar, R., Walkup, D., Zhou, W., … Madhavan,
    V. (2015). Dirac mass generation from crystal symmetry breaking on the surfaces
    of topological crystalline insulators. <i>Nature Materials</i>. Nature Publishing
    Group. <a href="https://doi.org/10.1038/nmat4215">https://doi.org/10.1038/nmat4215</a>
  chicago: Zeljkovic, Ilija, Yoshinori Okada, Maksym Serbyn, Raman Sankar, Daniel
    Walkup, Wenwen Zhou, Junwei Liu, et al. “Dirac Mass Generation from Crystal Symmetry
    Breaking on the Surfaces of Topological Crystalline Insulators.” <i>Nature Materials</i>.
    Nature Publishing Group, 2015. <a href="https://doi.org/10.1038/nmat4215">https://doi.org/10.1038/nmat4215</a>.
  ieee: I. Zeljkovic <i>et al.</i>, “Dirac mass generation from crystal symmetry breaking
    on the surfaces of topological crystalline insulators,” <i>Nature Materials</i>,
    vol. 14, no. 3. Nature Publishing Group, pp. 318–324, 2015.
  ista: Zeljkovic I, Okada Y, Serbyn M, Sankar R, Walkup D, Zhou W, Liu J, Chang G,
    Wang Y, Hasan M, Chou F, Lin H, Bansil A, Fu L, Madhavan V. 2015. Dirac mass generation
    from crystal symmetry breaking on the surfaces of topological crystalline insulators.
    Nature Materials. 14(3), 318–324.
  mla: Zeljkovic, Ilija, et al. “Dirac Mass Generation from Crystal Symmetry Breaking
    on the Surfaces of Topological Crystalline Insulators.” <i>Nature Materials</i>,
    vol. 14, no. 3, Nature Publishing Group, 2015, pp. 318–24, doi:<a href="https://doi.org/10.1038/nmat4215">10.1038/nmat4215</a>.
  short: I. Zeljkovic, Y. Okada, M. Serbyn, R. Sankar, D. Walkup, W. Zhou, J. Liu,
    G. Chang, Y. Wang, M. Hasan, F. Chou, H. Lin, A. Bansil, L. Fu, V. Madhavan, Nature
    Materials 14 (2015) 318–324.
date_created: 2018-12-11T11:49:31Z
date_published: 2015-03-01T00:00:00Z
date_updated: 2021-01-12T08:22:24Z
day: '01'
doi: 10.1038/nmat4215
extern: 1
intvolume: '        14'
issue: '3'
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1403.4906
month: '03'
oa: 1
page: 318 - 324
publication: Nature Materials
publication_status: published
publisher: Nature Publishing Group
publist_id: '6419'
quality_controlled: 0
status: public
title: Dirac mass generation from crystal symmetry breaking on the surfaces of topological
  crystalline insulators
type: journal_article
volume: 14
year: '2015'
...
---
_id: '982'
abstract:
- lang: eng
  text: We propose a new approach to probing ergodicity and its breakdown in one-dimensional
    quantum manybody systems based on their response to a local perturbation. We study
    the distribution of matrix elements of a local operator between the system's eigenstates,
    finding a qualitatively different behavior in the manybody localized (MBL) and
    ergodic phases. To characterize how strongly a local perturbation modifies the
    eigenstates, we introduce the parameter g(L) = (In (Vnm/δ)) which represents the
    disorder-averaged ratio of a typical matrix element of a local operator V to energy
    level spacing δ this parameter is reminiscent of the Thouless conductance in the
    single-particle localization. We show that the parameter g(L) decreases with system
    size L in the MBL phase and grows in the ergodic phase. We surmise that the delocalization
    transition occurs when g(L) is independent of system size, g(L)=gc ~ 1. We illustrate
    our approach by studying the many-body localization transition and resolving the
    many-body mobility edge in a disordered one-dimensional XXZ spin-1=2 chain using
    exact diagonalization and time-evolving block-decimation methods. Our criterion
    for the MBL transition gives insights into microscopic details of transition.
    Its direct physical consequences, in particular, logarithmically slow transport
    at the transition and extensive entanglement entropy of the eigenstates, are consistent
    with recent renormalization-group predictions.
acknowledgement: We acknowledge helpful discussions with Sid Parameswaran, Andrew
  Potter, Antonello Scardicchio, Romain Vasseur, and especially with Ehud Altman and
  David Huse. We would like to thank Miles Stoudenmire for the assistance with ITensor
  library. Research at Perimeter Institute is supported by the Government of Canada
  through Industry Canada and by the Province of Ontario through the Ministry of Economic
  Development & Innovation. This research was supported by Gordon and Betty Moore
  Foundation EPiQS Initiative through Grant No. GBMF4307 (M. S.), Sloan Foundation,
  NSERC, and Early Researcher Award of Ontario (D. A.). This work made use of the
  facilities of N8 HPC Centre of Excellence, provided and funded by the N8 consortium
  and EPSRC (Grant No. EP/K000225/1). The Centre is coordinated by the Universities
  of Leeds and Manchester.
author:
- first_name: Maksym
  full_name: Maksym Serbyn
  id: 47809E7E-F248-11E8-B48F-1D18A9856A87
  last_name: Serbyn
  orcid: 0000-0002-2399-5827
- first_name: Zlatko
  full_name: Papić, Zlatko
  last_name: Papić
- first_name: Dmitry
  full_name: Abanin, Dmitry A
  last_name: Abanin
citation:
  ama: Serbyn M, Papić Z, Abanin D. Criterion for many-body localization-delocalization
    phase transition. <i>Physical Review X</i>. 2015;5(4). doi:<a href="https://doi.org/10.1103/PhysRevX.5.041047">10.1103/PhysRevX.5.041047</a>
  apa: Serbyn, M., Papić, Z., &#38; Abanin, D. (2015). Criterion for many-body localization-delocalization
    phase transition. <i>Physical Review X</i>. American Physical Society. <a href="https://doi.org/10.1103/PhysRevX.5.041047">https://doi.org/10.1103/PhysRevX.5.041047</a>
  chicago: Serbyn, Maksym, Zlatko Papić, and Dmitry Abanin. “Criterion for Many-Body
    Localization-Delocalization Phase Transition.” <i>Physical Review X</i>. American
    Physical Society, 2015. <a href="https://doi.org/10.1103/PhysRevX.5.041047">https://doi.org/10.1103/PhysRevX.5.041047</a>.
  ieee: M. Serbyn, Z. Papić, and D. Abanin, “Criterion for many-body localization-delocalization
    phase transition,” <i>Physical Review X</i>, vol. 5, no. 4. American Physical
    Society, 2015.
  ista: Serbyn M, Papić Z, Abanin D. 2015. Criterion for many-body localization-delocalization
    phase transition. Physical Review X. 5(4).
  mla: Serbyn, Maksym, et al. “Criterion for Many-Body Localization-Delocalization
    Phase Transition.” <i>Physical Review X</i>, vol. 5, no. 4, American Physical
    Society, 2015, doi:<a href="https://doi.org/10.1103/PhysRevX.5.041047">10.1103/PhysRevX.5.041047</a>.
  short: M. Serbyn, Z. Papić, D. Abanin, Physical Review X 5 (2015).
date_created: 2018-12-11T11:49:32Z
date_published: 2015-01-01T00:00:00Z
date_updated: 2021-01-12T08:22:25Z
day: '01'
doi: 10.1103/PhysRevX.5.041047
extern: 1
intvolume: '         5'
issue: '4'
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1507.01635
month: '01'
oa: 1
publication: Physical Review X
publication_status: published
publisher: American Physical Society
publist_id: '6418'
quality_controlled: 0
status: public
title: Criterion for many-body localization-delocalization phase transition
type: journal_article
volume: 5
year: '2015'
...
---
_id: '6507'
abstract:
- lang: eng
  text: The osteoclast-associated receptor (OSCAR) is a collagen-binding immune receptor
    with important roles in dendritic cell maturation and activation of inflammatory
    monocytes as well as in osteoclastogenesis. The crystal structure of the OSCAR
    ectodomain is presented, both free and in complex with a consensus triple-helical
    peptide (THP). The structures revealed a collagen-binding site in each immunoglobulin-like
    domain (D1 and D2). The THP binds near a predicted collagen-binding groove in
    D1, but a more extensive interaction with D2 is facilitated by the unusually wide
    D1-D2 interdomain angle in OSCAR. Direct binding assays, combined with site-directed
    mutagenesis, confirm that the primary collagen-binding site in OSCAR resides in
    D2, in marked contrast to the related collagen receptors, glycoprotein VI (GPVI)
    and leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1). Monomeric OSCAR
    D1D2 binds to the consensus THP with a KD of 28 µM measured in solution, but shows
    a higher affinity (KD 1.5 μM) when binding to a solid-phase THP, most likely due
    to an avidity effect. These data suggest a 2-stage model for the interaction of
    OSCAR with a collagen fibril, with transient, low-affinity interactions initiated
    by the membrane-distal D1, followed by firm adhesion to the primary binding site
    in D2.
author:
- first_name: Long
  full_name: Zhou, Long
  id: 3E751364-F248-11E8-B48F-1D18A9856A87
  last_name: Zhou
  orcid: 0000-0002-1864-8951
- first_name: J. M.
  full_name: Hinerman, J. M.
  last_name: Hinerman
- first_name: M.
  full_name: Blaszczyk, M.
  last_name: Blaszczyk
- first_name: J. L. C.
  full_name: Miller, J. L. C.
  last_name: Miller
- first_name: D. G.
  full_name: Conrady, D. G.
  last_name: Conrady
- first_name: A. D.
  full_name: Barrow, A. D.
  last_name: Barrow
- first_name: D. Y.
  full_name: Chirgadze, D. Y.
  last_name: Chirgadze
- first_name: D.
  full_name: Bihan, D.
  last_name: Bihan
- first_name: R. W.
  full_name: Farndale, R. W.
  last_name: Farndale
- first_name: A. B.
  full_name: Herr, A. B.
  last_name: Herr
citation:
  ama: Zhou L, Hinerman JM, Blaszczyk M, et al. Structural basis for collagen recognition
    by the immune receptor OSCAR. <i>Blood</i>. 2015;127(5):529-537. doi:<a href="https://doi.org/10.1182/blood-2015-08-667055">10.1182/blood-2015-08-667055</a>
  apa: Zhou, L., Hinerman, J. M., Blaszczyk, M., Miller, J. L. C., Conrady, D. G.,
    Barrow, A. D., … Herr, A. B. (2015). Structural basis for collagen recognition
    by the immune receptor OSCAR. <i>Blood</i>. American Society of Hematology. <a
    href="https://doi.org/10.1182/blood-2015-08-667055">https://doi.org/10.1182/blood-2015-08-667055</a>
  chicago: Zhou, Long, J. M. Hinerman, M. Blaszczyk, J. L. C. Miller, D. G. Conrady,
    A. D. Barrow, D. Y. Chirgadze, D. Bihan, R. W. Farndale, and A. B. Herr. “Structural
    Basis for Collagen Recognition by the Immune Receptor OSCAR.” <i>Blood</i>. American
    Society of Hematology, 2015. <a href="https://doi.org/10.1182/blood-2015-08-667055">https://doi.org/10.1182/blood-2015-08-667055</a>.
  ieee: L. Zhou <i>et al.</i>, “Structural basis for collagen recognition by the immune
    receptor OSCAR,” <i>Blood</i>, vol. 127, no. 5. American Society of Hematology,
    pp. 529–537, 2015.
  ista: Zhou L, Hinerman JM, Blaszczyk M, Miller JLC, Conrady DG, Barrow AD, Chirgadze
    DY, Bihan D, Farndale RW, Herr AB. 2015. Structural basis for collagen recognition
    by the immune receptor OSCAR. Blood. 127(5), 529–537.
  mla: Zhou, Long, et al. “Structural Basis for Collagen Recognition by the Immune
    Receptor OSCAR.” <i>Blood</i>, vol. 127, no. 5, American Society of Hematology,
    2015, pp. 529–37, doi:<a href="https://doi.org/10.1182/blood-2015-08-667055">10.1182/blood-2015-08-667055</a>.
  short: L. Zhou, J.M. Hinerman, M. Blaszczyk, J.L.C. Miller, D.G. Conrady, A.D. Barrow,
    D.Y. Chirgadze, D. Bihan, R.W. Farndale, A.B. Herr, Blood 127 (2015) 529–537.
date_created: 2019-05-31T09:38:50Z
date_published: 2015-11-02T00:00:00Z
date_updated: 2021-01-12T08:07:47Z
day: '02'
doi: 10.1182/blood-2015-08-667055
extern: '1'
external_id:
  pmid:
  - '26552697'
intvolume: '       127'
issue: '5'
language:
- iso: eng
month: '11'
oa_version: None
page: 529-537
pmid: 1
publication: Blood
publication_identifier:
  issn:
  - 0006-4971
  - 1528-0020
publication_status: published
publisher: American Society of Hematology
quality_controlled: '1'
status: public
title: Structural basis for collagen recognition by the immune receptor OSCAR
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 127
year: '2015'
...
---
_id: '6736'
abstract:
- lang: eng
  text: Motivated by the significant performance gains which polar codes experience
    under successive cancellation list decoding, their scaling exponent is studied
    as a function of the list size. In particular, the error probability is fixed,
    and the tradeoff between the block length and back-off from capacity is analyzed.
    A lower bound is provided on the error probability under MAP decoding with list
    size L for any binary-input memoryless output-symmetric channel and for any class
    of linear codes such that their minimum distance is unbounded as the block length
    grows large. Then, it is shown that under MAP decoding, although the introduction
    of a list can significantly improve the involved constants, the scaling exponent
    itself, i.e., the speed at which capacity is approached, stays unaffected for
    any finite list size. In particular, this result applies to polar codes, since
    their minimum distance tends to infinity as the block length increases. A similar
    result is proved for genie-aided successive cancellation decoding when transmission
    takes place over the binary erasure channel, namely, the scaling exponent remains
    constant for any fixed number of helps from the genie. Note that since genie-aided
    successive cancellation decoding might be strictly worse than successive cancellation
    list decoding, the problem of establishing the scaling exponent of the latter
    remains open.
arxiv: 1
author:
- first_name: Marco
  full_name: Mondelli, Marco
  id: 27EB676C-8706-11E9-9510-7717E6697425
  last_name: Mondelli
  orcid: 0000-0002-3242-7020
- first_name: Hamed
  full_name: Hassani, Hamed
  last_name: Hassani
- first_name: Rudiger
  full_name: Urbanke, Rudiger
  last_name: Urbanke
citation:
  ama: Mondelli M, Hassani H, Urbanke R. Scaling exponent of list decoders with applications
    to polar codes. <i>IEEE Transactions on Information Theory</i>. 2015;61(9):4838-4851.
    doi:<a href="https://doi.org/10.1109/tit.2015.2453315">10.1109/tit.2015.2453315</a>
  apa: Mondelli, M., Hassani, H., &#38; Urbanke, R. (2015). Scaling exponent of list
    decoders with applications to polar codes. <i>IEEE Transactions on Information
    Theory</i>. IEEE. <a href="https://doi.org/10.1109/tit.2015.2453315">https://doi.org/10.1109/tit.2015.2453315</a>
  chicago: Mondelli, Marco, Hamed Hassani, and Rudiger Urbanke. “Scaling Exponent
    of List Decoders with Applications to Polar Codes.” <i>IEEE Transactions on Information
    Theory</i>. IEEE, 2015. <a href="https://doi.org/10.1109/tit.2015.2453315">https://doi.org/10.1109/tit.2015.2453315</a>.
  ieee: M. Mondelli, H. Hassani, and R. Urbanke, “Scaling exponent of list decoders
    with applications to polar codes,” <i>IEEE Transactions on Information Theory</i>,
    vol. 61, no. 9. IEEE, pp. 4838–4851, 2015.
  ista: Mondelli M, Hassani H, Urbanke R. 2015. Scaling exponent of list decoders
    with applications to polar codes. IEEE Transactions on Information Theory. 61(9),
    4838–4851.
  mla: Mondelli, Marco, et al. “Scaling Exponent of List Decoders with Applications
    to Polar Codes.” <i>IEEE Transactions on Information Theory</i>, vol. 61, no.
    9, IEEE, 2015, pp. 4838–51, doi:<a href="https://doi.org/10.1109/tit.2015.2453315">10.1109/tit.2015.2453315</a>.
  short: M. Mondelli, H. Hassani, R. Urbanke, IEEE Transactions on Information Theory
    61 (2015) 4838–4851.
date_created: 2019-07-31T06:50:34Z
date_published: 2015-09-01T00:00:00Z
date_updated: 2021-01-12T08:08:45Z
day: '01'
doi: 10.1109/tit.2015.2453315
extern: '1'
external_id:
  arxiv:
  - '1304.5220'
intvolume: '        61'
issue: '9'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1304.5220
month: '09'
oa: 1
oa_version: Preprint
page: 4838-4851
publication: IEEE Transactions on Information Theory
publication_status: published
publisher: IEEE
quality_controlled: '1'
status: public
title: Scaling exponent of list decoders with applications to polar codes
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 61
year: '2015'
...
---
_id: '6737'
abstract:
- lang: eng
  text: This paper presents polar coding schemes for the two-user discrete memoryless
    broadcast channel (DM-BC) which achieve Marton's region with both common and private
    messages. This is the best achievable rate region known to date, and it is tight
    for all classes of two-user DM-BCs whose capacity regions are known. To accomplish
    this task, we first construct polar codes for both the superposition as well as
    binning strategy. By combining these two schemes, we obtain Marton's region with
    private messages only. Finally, we show how to handle the case of common information.
    The proposed coding schemes possess the usual advantages of polar codes, i.e.,
    they have low encoding and decoding complexity and a superpolynomial decay rate
    of the error probability. We follow the lead of Goela, Abbe, and Gastpar, who
    recently introduced polar codes emulating the superposition and binning schemes.
    To align the polar indices, for both schemes, their solution involves some degradedness
    constraints that are assumed to hold between the auxiliary random variables and
    channel outputs. To remove these constraints, we consider the transmission of
    k blocks and employ a chaining construction that guarantees the proper alignment
    of the polarized indices. The techniques described in this paper are quite general,
    and they can be adopted to many other multiterminal scenarios whenever there polar
    indices need to be aligned.
arxiv: 1
author:
- first_name: Marco
  full_name: Mondelli, Marco
  id: 27EB676C-8706-11E9-9510-7717E6697425
  last_name: Mondelli
  orcid: 0000-0002-3242-7020
- first_name: Hamed
  full_name: Hassani, Hamed
  last_name: Hassani
- first_name: Igal
  full_name: Sason, Igal
  last_name: Sason
- first_name: Rudiger
  full_name: Urbanke, Rudiger
  last_name: Urbanke
citation:
  ama: Mondelli M, Hassani H, Sason I, Urbanke R. Achieving Marton’s region for broadcast
    channels using polar codes. <i>IEEE Transactions on Information Theory</i>. 2015;61(2):783-800.
    doi:<a href="https://doi.org/10.1109/tit.2014.2368555">10.1109/tit.2014.2368555</a>
  apa: Mondelli, M., Hassani, H., Sason, I., &#38; Urbanke, R. (2015). Achieving Marton’s
    region for broadcast channels using polar codes. <i>IEEE Transactions on Information
    Theory</i>. IEEE. <a href="https://doi.org/10.1109/tit.2014.2368555">https://doi.org/10.1109/tit.2014.2368555</a>
  chicago: Mondelli, Marco, Hamed Hassani, Igal Sason, and Rudiger Urbanke. “Achieving
    Marton’s Region for Broadcast Channels Using Polar Codes.” <i>IEEE Transactions
    on Information Theory</i>. IEEE, 2015. <a href="https://doi.org/10.1109/tit.2014.2368555">https://doi.org/10.1109/tit.2014.2368555</a>.
  ieee: M. Mondelli, H. Hassani, I. Sason, and R. Urbanke, “Achieving Marton’s region
    for broadcast channels using polar codes,” <i>IEEE Transactions on Information
    Theory</i>, vol. 61, no. 2. IEEE, pp. 783–800, 2015.
  ista: Mondelli M, Hassani H, Sason I, Urbanke R. 2015. Achieving Marton’s region
    for broadcast channels using polar codes. IEEE Transactions on Information Theory.
    61(2), 783–800.
  mla: Mondelli, Marco, et al. “Achieving Marton’s Region for Broadcast Channels Using
    Polar Codes.” <i>IEEE Transactions on Information Theory</i>, vol. 61, no. 2,
    IEEE, 2015, pp. 783–800, doi:<a href="https://doi.org/10.1109/tit.2014.2368555">10.1109/tit.2014.2368555</a>.
  short: M. Mondelli, H. Hassani, I. Sason, R. Urbanke, IEEE Transactions on Information
    Theory 61 (2015) 783–800.
date_created: 2019-07-31T07:03:38Z
date_published: 2015-02-01T00:00:00Z
date_updated: 2021-01-12T08:08:46Z
day: '01'
doi: 10.1109/tit.2014.2368555
extern: '1'
external_id:
  arxiv:
  - '1401.6060'
intvolume: '        61'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1401.6060
month: '02'
oa: 1
oa_version: Preprint
page: 783-800
publication: IEEE Transactions on Information Theory
publication_status: published
publisher: IEEE
quality_controlled: '1'
status: public
title: Achieving Marton’s region for broadcast channels using polar codes
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 61
year: '2015'
...
---
_id: '7070'
abstract:
- lang: eng
  text: 'Torque magnetization measurements on YBa2Cu3Oy (YBCO) at doping y=6.67 (p=0.12),
    in dc fields (B) up to 33 T and temperatures down to 4.5 K, show that weak diamagnetism
    persists above the extrapolated irreversibility field Hirr(T=0)≈24 T. The differential
    susceptibility dM/dB, however, is more rapidly suppressed for B≳16 T than expected
    from the properties of the low field superconducting state, and saturates at a
    low value for fields B≳24 T. In addition, torque measurements on a p=0.11 YBCO
    crystal in pulsed field up to 65 T and temperatures down to 8 K show similar behavior,
    with no additional features at higher fields. We offer two candidate scenarios
    to explain these observations: (a) superconductivity survives but is heavily suppressed
    at high field by competition with charge-density-wave (CDW) order; (b) static
    superconductivity disappears near 24 T and is followed by a region of fluctuating
    superconductivity, which causes dM/dB to saturate at high field. The diamagnetic
    signal observed above 50 T for the p=0.11 crystal at 40 K and below may be caused
    by changes in the normal state susceptibility rather than bulk or fluctuating
    superconductivity. There will be orbital (Landau) diamagnetism from electron pockets
    and possibly a reduction in spin susceptibility caused by the stronger three-dimensional
    ordered CDW.'
article_number: '180509'
article_processing_charge: No
article_type: original
author:
- first_name: Jing Fei
  full_name: Yu, Jing Fei
  last_name: Yu
- first_name: B. J.
  full_name: Ramshaw, B. J.
  last_name: Ramshaw
- first_name: I.
  full_name: Kokanović, I.
  last_name: Kokanović
- first_name: Kimberly A
  full_name: Modic, Kimberly A
  id: 13C26AC0-EB69-11E9-87C6-5F3BE6697425
  last_name: Modic
  orcid: 0000-0001-9760-3147
- first_name: N.
  full_name: Harrison, N.
  last_name: Harrison
- first_name: James
  full_name: Day, James
  last_name: Day
- first_name: Ruixing
  full_name: Liang, Ruixing
  last_name: Liang
- first_name: W. N.
  full_name: Hardy, W. N.
  last_name: Hardy
- first_name: D. A.
  full_name: Bonn, D. A.
  last_name: Bonn
- first_name: A.
  full_name: McCollam, A.
  last_name: McCollam
- first_name: S. R.
  full_name: Julian, S. R.
  last_name: Julian
- first_name: J. R.
  full_name: Cooper, J. R.
  last_name: Cooper
citation:
  ama: Yu JF, Ramshaw BJ, Kokanović I, et al. Magnetization of underdoped YBa2Cu3Oy
    above the irreversibility field. <i>Physical Review B</i>. 2015;92(18). doi:<a
    href="https://doi.org/10.1103/physrevb.92.180509">10.1103/physrevb.92.180509</a>
  apa: Yu, J. F., Ramshaw, B. J., Kokanović, I., Modic, K. A., Harrison, N., Day,
    J., … Cooper, J. R. (2015). Magnetization of underdoped YBa2Cu3Oy above the irreversibility
    field. <i>Physical Review B</i>. APS. <a href="https://doi.org/10.1103/physrevb.92.180509">https://doi.org/10.1103/physrevb.92.180509</a>
  chicago: Yu, Jing Fei, B. J. Ramshaw, I. Kokanović, Kimberly A Modic, N. Harrison,
    James Day, Ruixing Liang, et al. “Magnetization of Underdoped YBa2Cu3Oy above
    the Irreversibility Field.” <i>Physical Review B</i>. APS, 2015. <a href="https://doi.org/10.1103/physrevb.92.180509">https://doi.org/10.1103/physrevb.92.180509</a>.
  ieee: J. F. Yu <i>et al.</i>, “Magnetization of underdoped YBa2Cu3Oy above the irreversibility
    field,” <i>Physical Review B</i>, vol. 92, no. 18. APS, 2015.
  ista: Yu JF, Ramshaw BJ, Kokanović I, Modic KA, Harrison N, Day J, Liang R, Hardy
    WN, Bonn DA, McCollam A, Julian SR, Cooper JR. 2015. Magnetization of underdoped
    YBa2Cu3Oy above the irreversibility field. Physical Review B. 92(18), 180509.
  mla: Yu, Jing Fei, et al. “Magnetization of Underdoped YBa2Cu3Oy above the Irreversibility
    Field.” <i>Physical Review B</i>, vol. 92, no. 18, 180509, APS, 2015, doi:<a href="https://doi.org/10.1103/physrevb.92.180509">10.1103/physrevb.92.180509</a>.
  short: J.F. Yu, B.J. Ramshaw, I. Kokanović, K.A. Modic, N. Harrison, J. Day, R.
    Liang, W.N. Hardy, D.A. Bonn, A. McCollam, S.R. Julian, J.R. Cooper, Physical
    Review B 92 (2015).
date_created: 2019-11-19T13:22:06Z
date_published: 2015-11-23T00:00:00Z
date_updated: 2021-01-12T08:11:42Z
day: '23'
doi: 10.1103/physrevb.92.180509
extern: '1'
intvolume: '        92'
issue: '18'
language:
- iso: eng
month: '11'
oa_version: None
publication: Physical Review B
publication_identifier:
  issn:
  - 1098-0121
  - 1550-235X
publication_status: published
publisher: APS
quality_controlled: '1'
status: public
title: Magnetization of underdoped YBa2Cu3Oy above the irreversibility field
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 92
year: '2015'
...
---
_id: '7456'
abstract:
- lang: eng
  text: The rational design of monodisperse ferroelectric nanocrystals with controlled
    size and shape and their organization into hierarchical structures has been a
    critical step for understanding the polar ordering in nanoscale ferroelectrics,
    as well as the design of nanocrystal-based functional materials which harness
    the properties of individual nanoparticles and the collective interactions between
    them. We report here on the synthesis and self-assembly of aggregate-free, single-crystalline
    titanium-based perovskite nanoparticles with controlled morphology and surface
    composition by using a simple, easily scalable and highly versatile colloidal
    route. Single-crystalline, non-aggregated BaTiO3 colloidal nanocrystals, used
    as a model system, have been prepared under solvothermal conditions at temperatures
    as low as 180 °C. The shape of the nanocrystals was tuned from spheroidal to cubic
    upon changing the polarity of the solvent, whereas their size was varied from
    16 to 30 nm for spheres and 5 to 78 nm for cubes by changing the concentration
    of the precursors and the reaction time, respectively. The hydrophobic, oleic
    acid-passivated nanoparticles exhibit very good solubility in non-polar solvents
    and can be rendered dispersible in polar solvents by a simple process involving
    the oxidative cleavage of the double bond upon treating the nanopowders with the
    Lemieux–von Rudloff reagent. Lattice dynamic analysis indicated that regardless
    of their size, BaTiO3 nanocrystals present local disorder within the perovskite
    unit cell, associated with the existence of polar ordering. We also demonstrate
    for the first time that, in addition to being used for fabricating large area,
    crack-free, highly uniform films, BaTiO3 nanocubes can serve as building blocks
    for the design of 2D and 3D mesoscale structures, such as superlattices and superparticles.
    Interestingly, the type of superlattice structure (simple cubic or face centered
    cubic) appears to be determined by the type of solvent in which the nanocrystals
    were dispersed. This approach provides an excellent platform for the synthesis
    of other titanium-based perovskite colloidal nanocrystals with controlled chemical
    composition, surface structure and morphology and for their assembly into complex
    architectures, therefore opening the door for the design of novel mesoscale functional
    materials/nanocomposites with potential applications in energy conversion, data
    storage and the biomedical field.
article_processing_charge: No
article_type: original
author:
- first_name: Daniela
  full_name: Caruntu, Daniela
  last_name: Caruntu
- first_name: Taha
  full_name: Rostamzadeh, Taha
  last_name: Rostamzadeh
- first_name: Tommaso
  full_name: Costanzo, Tommaso
  id: D93824F4-D9BA-11E9-BB12-F207E6697425
  last_name: Costanzo
  orcid: 0000-0001-9732-3815
- first_name: Saman
  full_name: Salemizadeh Parizi, Saman
  last_name: Salemizadeh Parizi
- first_name: Gabriel
  full_name: Caruntu, Gabriel
  last_name: Caruntu
citation:
  ama: Caruntu D, Rostamzadeh T, Costanzo T, Salemizadeh Parizi S, Caruntu G. Solvothermal
    synthesis and controlled self-assembly of monodisperse titanium-based perovskite
    colloidal nanocrystals. <i>Nanoscale</i>. 2015;7(30):12955-12969. doi:<a href="https://doi.org/10.1039/c5nr00737b">10.1039/c5nr00737b</a>
  apa: Caruntu, D., Rostamzadeh, T., Costanzo, T., Salemizadeh Parizi, S., &#38; Caruntu,
    G. (2015). Solvothermal synthesis and controlled self-assembly of monodisperse
    titanium-based perovskite colloidal nanocrystals. <i>Nanoscale</i>. RSC. <a href="https://doi.org/10.1039/c5nr00737b">https://doi.org/10.1039/c5nr00737b</a>
  chicago: Caruntu, Daniela, Taha Rostamzadeh, Tommaso Costanzo, Saman Salemizadeh
    Parizi, and Gabriel Caruntu. “Solvothermal Synthesis and Controlled Self-Assembly
    of Monodisperse Titanium-Based Perovskite Colloidal Nanocrystals.” <i>Nanoscale</i>.
    RSC, 2015. <a href="https://doi.org/10.1039/c5nr00737b">https://doi.org/10.1039/c5nr00737b</a>.
  ieee: D. Caruntu, T. Rostamzadeh, T. Costanzo, S. Salemizadeh Parizi, and G. Caruntu,
    “Solvothermal synthesis and controlled self-assembly of monodisperse titanium-based
    perovskite colloidal nanocrystals,” <i>Nanoscale</i>, vol. 7, no. 30. RSC, pp.
    12955–12969, 2015.
  ista: Caruntu D, Rostamzadeh T, Costanzo T, Salemizadeh Parizi S, Caruntu G. 2015.
    Solvothermal synthesis and controlled self-assembly of monodisperse titanium-based
    perovskite colloidal nanocrystals. Nanoscale. 7(30), 12955–12969.
  mla: Caruntu, Daniela, et al. “Solvothermal Synthesis and Controlled Self-Assembly
    of Monodisperse Titanium-Based Perovskite Colloidal Nanocrystals.” <i>Nanoscale</i>,
    vol. 7, no. 30, RSC, 2015, pp. 12955–69, doi:<a href="https://doi.org/10.1039/c5nr00737b">10.1039/c5nr00737b</a>.
  short: D. Caruntu, T. Rostamzadeh, T. Costanzo, S. Salemizadeh Parizi, G. Caruntu,
    Nanoscale 7 (2015) 12955–12969.
date_created: 2020-02-05T14:16:37Z
date_published: 2015-08-14T00:00:00Z
date_updated: 2023-02-23T13:08:24Z
day: '14'
doi: 10.1039/c5nr00737b
extern: '1'
external_id:
  pmid:
  - '26168304'
intvolume: '         7'
issue: '30'
language:
- iso: eng
month: '08'
oa_version: None
page: 12955-12969
pmid: 1
publication: Nanoscale
publication_identifier:
  issn:
  - 2040-3364
  - 2040-3372
publication_status: published
publisher: RSC
quality_controlled: '1'
status: public
title: Solvothermal synthesis and controlled self-assembly of monodisperse titanium-based
  perovskite colloidal nanocrystals
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 7
year: '2015'
...
---
_id: '7457'
abstract:
- lang: eng
  text: A new organic–inorganic ferroelectric hybrid capacitor designed by uniformly
    incorporating surface modified monodisperse 15 nm ferroelectric BaTiO3 nanocubes
    into non-polar polymer blends of poly(methyl methacrylate) (PMMA) polymer and
    acrylonitrile-butadiene-styrene (ABS) terpolymer is described. The investigation
    of spatial distribution of nanofillers via a non-distractive thermal pulse method
    illustrates that the surface functionalization of nanocubes plays a key role in
    the uniform distribution of charge polarization within the polymer matrix. The
    discharged energy density of the nanocomposite with 30 vol% BaTiO3 nanocubes is
    ∼44 × 10−3 J cm−3, which is almost six times higher than that of the neat polymer.
    The facile processing, along with the superior mechanical and electrical properties
    of the BaTiO3/PMMA–ABS nanocomposites make them suitable for implementation into
    capacitive electrical energy storage devices.
article_processing_charge: No
article_type: original
author:
- first_name: Saman Salemizadeh
  full_name: Parizi, Saman Salemizadeh
  last_name: Parizi
- first_name: Gavin
  full_name: Conley, Gavin
  last_name: Conley
- first_name: Tommaso
  full_name: Costanzo, Tommaso
  id: D93824F4-D9BA-11E9-BB12-F207E6697425
  last_name: Costanzo
  orcid: 0000-0001-9732-3815
- first_name: Bob
  full_name: Howell, Bob
  last_name: Howell
- first_name: Axel
  full_name: Mellinger, Axel
  last_name: Mellinger
- first_name: Gabriel
  full_name: Caruntu, Gabriel
  last_name: Caruntu
citation:
  ama: Parizi SS, Conley G, Costanzo T, Howell B, Mellinger A, Caruntu G. Fabrication
    of barium titanate/acrylonitrile-butadiene styrene/poly(methyl methacrylate) nanocomposite
    films for hybrid ferroelectric capacitors. <i>RSC Advances</i>. 2015;5(93):76356-76362.
    doi:<a href="https://doi.org/10.1039/c5ra11347d">10.1039/c5ra11347d</a>
  apa: Parizi, S. S., Conley, G., Costanzo, T., Howell, B., Mellinger, A., &#38; Caruntu,
    G. (2015). Fabrication of barium titanate/acrylonitrile-butadiene styrene/poly(methyl
    methacrylate) nanocomposite films for hybrid ferroelectric capacitors. <i>RSC
    Advances</i>. RSC. <a href="https://doi.org/10.1039/c5ra11347d">https://doi.org/10.1039/c5ra11347d</a>
  chicago: Parizi, Saman Salemizadeh, Gavin Conley, Tommaso Costanzo, Bob Howell,
    Axel Mellinger, and Gabriel Caruntu. “Fabrication of Barium Titanate/Acrylonitrile-Butadiene
    Styrene/Poly(Methyl Methacrylate) Nanocomposite Films for Hybrid Ferroelectric
    Capacitors.” <i>RSC Advances</i>. RSC, 2015. <a href="https://doi.org/10.1039/c5ra11347d">https://doi.org/10.1039/c5ra11347d</a>.
  ieee: S. S. Parizi, G. Conley, T. Costanzo, B. Howell, A. Mellinger, and G. Caruntu,
    “Fabrication of barium titanate/acrylonitrile-butadiene styrene/poly(methyl methacrylate)
    nanocomposite films for hybrid ferroelectric capacitors,” <i>RSC Advances</i>,
    vol. 5, no. 93. RSC, pp. 76356–76362, 2015.
  ista: Parizi SS, Conley G, Costanzo T, Howell B, Mellinger A, Caruntu G. 2015. Fabrication
    of barium titanate/acrylonitrile-butadiene styrene/poly(methyl methacrylate) nanocomposite
    films for hybrid ferroelectric capacitors. RSC Advances. 5(93), 76356–76362.
  mla: Parizi, Saman Salemizadeh, et al. “Fabrication of Barium Titanate/Acrylonitrile-Butadiene
    Styrene/Poly(Methyl Methacrylate) Nanocomposite Films for Hybrid Ferroelectric
    Capacitors.” <i>RSC Advances</i>, vol. 5, no. 93, RSC, 2015, pp. 76356–62, doi:<a
    href="https://doi.org/10.1039/c5ra11347d">10.1039/c5ra11347d</a>.
  short: S.S. Parizi, G. Conley, T. Costanzo, B. Howell, A. Mellinger, G. Caruntu,
    RSC Advances 5 (2015) 76356–76362.
date_created: 2020-02-05T14:17:26Z
date_published: 2015-09-01T00:00:00Z
date_updated: 2023-02-23T13:08:26Z
day: '01'
doi: 10.1039/c5ra11347d
extern: '1'
intvolume: '         5'
issue: '93'
language:
- iso: eng
month: '09'
oa_version: Submitted Version
page: 76356-76362
publication: RSC Advances
publication_identifier:
  issn:
  - 2046-2069
publication_status: published
publisher: RSC
quality_controlled: '1'
status: public
title: Fabrication of barium titanate/acrylonitrile-butadiene styrene/poly(methyl
  methacrylate) nanocomposite films for hybrid ferroelectric capacitors
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 5
year: '2015'
...
---
_id: '99'
abstract:
- lang: eng
  text: Quasiparticle excitations can compromise the performance of superconducting
    devices, causing high-frequency dissipation, decoherence in Josephson qubits,
    and braiding errors in proposed Majorana-based topological quantum computers.
    Quasiparticle dynamics have been studied in detail in metallic superconductors
    but remain relatively unexplored in semiconductor-superconductor structures, which
    are now being intensely pursued in the context of topological superconductivity.
    To this end, we use a system comprising a gate-confined semiconductor nanowire
    with an epitaxially grown superconductor layer, yielding an isolated, proximitized
    nanowire segment. We identify bound states in the semiconductor by means of bias
    spectroscopy, determine the characteristic temperatures and magnetic fields for
    quasiparticle excitations, and extract a parity lifetime (poisoning time) of the
    bound state in the semiconductor exceeding 10 ms.
acknowledgement: Research support by Microsoft Project Q, the Danish National Research
  Foundation, the Lundbeck Foundation, the Carlsberg Foundation, and the European
  Commission. A.P.H. acknowledges support from the US Department of Energy, C.M.M.
  acknowledges support from the Villum Foundation.
arxiv: 1
author:
- first_name: Andrew P
  full_name: Higginbotham, Andrew P
  id: 4AD6785A-F248-11E8-B48F-1D18A9856A87
  last_name: Higginbotham
  orcid: 0000-0003-2607-2363
- first_name: S M
  full_name: Albrecht, S M
  last_name: Albrecht
- first_name: Gediminas
  full_name: Kiršanskas, Gediminas
  last_name: Kiršanskas
- first_name: W
  full_name: Chang, W
  last_name: Chang
- first_name: Ferdinand
  full_name: Kuemmeth, Ferdinand
  last_name: Kuemmeth
- first_name: Peter
  full_name: Krogstrup, Peter
  last_name: Krogstrup
- first_name: Thomas
  full_name: Jespersen, Thomas
  last_name: Jespersen
- first_name: Jesper
  full_name: Nygård, Jesper
  last_name: Nygård
- first_name: Karsten
  full_name: Flensberg, Karsten
  last_name: Flensberg
- first_name: Charles
  full_name: Marcus, Charles
  last_name: Marcus
citation:
  ama: Higginbotham AP, Albrecht SM, Kiršanskas G, et al. Parity lifetime of bound
    states in a proximitized semiconductor nanowire. <i>Nature Physics</i>. 2015;11(12):1017-1021.
    doi:<a href="https://doi.org/10.1038/nphys3461">10.1038/nphys3461</a>
  apa: Higginbotham, A. P., Albrecht, S. M., Kiršanskas, G., Chang, W., Kuemmeth,
    F., Krogstrup, P., … Marcus, C. (2015). Parity lifetime of bound states in a proximitized
    semiconductor nanowire. <i>Nature Physics</i>. Nature Publishing Group. <a href="https://doi.org/10.1038/nphys3461">https://doi.org/10.1038/nphys3461</a>
  chicago: Higginbotham, Andrew P, S M Albrecht, Gediminas Kiršanskas, W Chang, Ferdinand
    Kuemmeth, Peter Krogstrup, Thomas Jespersen, Jesper Nygård, Karsten Flensberg,
    and Charles Marcus. “Parity Lifetime of Bound States in a Proximitized Semiconductor
    Nanowire.” <i>Nature Physics</i>. Nature Publishing Group, 2015. <a href="https://doi.org/10.1038/nphys3461">https://doi.org/10.1038/nphys3461</a>.
  ieee: A. P. Higginbotham <i>et al.</i>, “Parity lifetime of bound states in a proximitized
    semiconductor nanowire,” <i>Nature Physics</i>, vol. 11, no. 12. Nature Publishing
    Group, pp. 1017–1021, 2015.
  ista: Higginbotham AP, Albrecht SM, Kiršanskas G, Chang W, Kuemmeth F, Krogstrup
    P, Jespersen T, Nygård J, Flensberg K, Marcus C. 2015. Parity lifetime of bound
    states in a proximitized semiconductor nanowire. Nature Physics. 11(12), 1017–1021.
  mla: Higginbotham, Andrew P., et al. “Parity Lifetime of Bound States in a Proximitized
    Semiconductor Nanowire.” <i>Nature Physics</i>, vol. 11, no. 12, Nature Publishing
    Group, 2015, pp. 1017–21, doi:<a href="https://doi.org/10.1038/nphys3461">10.1038/nphys3461</a>.
  short: A.P. Higginbotham, S.M. Albrecht, G. Kiršanskas, W. Chang, F. Kuemmeth, P.
    Krogstrup, T. Jespersen, J. Nygård, K. Flensberg, C. Marcus, Nature Physics 11
    (2015) 1017–1021.
date_created: 2018-12-11T11:44:37Z
date_published: 2015-09-14T00:00:00Z
date_updated: 2021-01-12T08:22:28Z
day: '14'
doi: 10.1038/nphys3461
extern: '1'
external_id:
  arxiv:
  - '1501.05155'
intvolume: '        11'
issue: '12'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1501.05155
month: '09'
oa: 1
oa_version: Preprint
page: 1017 - 1021
publication: Nature Physics
publication_status: published
publisher: Nature Publishing Group
publist_id: '7955'
quality_controlled: '1'
status: public
title: Parity lifetime of bound states in a proximitized semiconductor nanowire
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 11
year: '2015'
...
---
_id: '1619'
abstract:
- lang: eng
  text: The emergence of drug resistant pathogens is a serious public health problem.
    It is a long-standing goal to predict rates of resistance evolution and design
    optimal treatment strategies accordingly. To this end, it is crucial to reveal
    the underlying causes of drug-specific differences in the evolutionary dynamics
    leading to resistance. However, it remains largely unknown why the rates of resistance
    evolution via spontaneous mutations and the diversity of mutational paths vary
    substantially between drugs. Here we comprehensively quantify the distribution
    of fitness effects (DFE) of mutations, a key determinant of evolutionary dynamics,
    in the presence of eight antibiotics representing the main modes of action. Using
    precise high-throughput fitness measurements for genome-wide Escherichia coli
    gene deletion strains, we find that the width of the DFE varies dramatically between
    antibiotics and, contrary to conventional wisdom, for some drugs the DFE width
    is lower than in the absence of stress. We show that this previously underappreciated
    divergence in DFE width among antibiotics is largely caused by their distinct
    drug-specific dose-response characteristics. Unlike the DFE, the magnitude of
    the changes in tolerated drug concentration resulting from genome-wide mutations
    is similar for most drugs but exceptionally small for the antibiotic nitrofurantoin,
    i.e., mutations generally have considerably smaller resistance effects for nitrofurantoin
    than for other drugs. A population genetics model predicts that resistance evolution
    for drugs with this property is severely limited and confined to reproducible
    mutational paths. We tested this prediction in laboratory evolution experiments
    using the “morbidostat”, a device for evolving bacteria in well-controlled drug
    environments. Nitrofurantoin resistance indeed evolved extremely slowly via reproducible
    mutations—an almost paradoxical behavior since this drug causes DNA damage and
    increases the mutation rate. Overall, we identified novel quantitative characteristics
    of the evolutionary landscape that provide the conceptual foundation for predicting
    the dynamics of drug resistance evolution.
article_number: e1002299
article_processing_charge: No
author:
- first_name: Guillaume
  full_name: Chevereau, Guillaume
  id: 424D78A0-F248-11E8-B48F-1D18A9856A87
  last_name: Chevereau
- first_name: Marta
  full_name: Dravecka, Marta
  id: 4342E402-F248-11E8-B48F-1D18A9856A87
  last_name: Dravecka
  orcid: 0000-0002-2519-8004
- first_name: Tugce
  full_name: Batur, Tugce
  last_name: Batur
- first_name: Aysegul
  full_name: Guvenek, Aysegul
  last_name: Guvenek
- first_name: Dilay
  full_name: Ayhan, Dilay
  last_name: Ayhan
- first_name: Erdal
  full_name: Toprak, Erdal
  last_name: Toprak
- first_name: Mark Tobias
  full_name: Bollenbach, Mark Tobias
  id: 3E6DB97A-F248-11E8-B48F-1D18A9856A87
  last_name: Bollenbach
  orcid: 0000-0003-4398-476X
citation:
  ama: Chevereau G, Lukacisinova M, Batur T, et al. Quantifying the determinants of
    evolutionary dynamics leading to drug resistance. <i>PLoS Biology</i>. 2015;13(11).
    doi:<a href="https://doi.org/10.1371/journal.pbio.1002299">10.1371/journal.pbio.1002299</a>
  apa: Chevereau, G., Lukacisinova, M., Batur, T., Guvenek, A., Ayhan, D., Toprak,
    E., &#38; Bollenbach, M. T. (2015). Quantifying the determinants of evolutionary
    dynamics leading to drug resistance. <i>PLoS Biology</i>. Public Library of Science.
    <a href="https://doi.org/10.1371/journal.pbio.1002299">https://doi.org/10.1371/journal.pbio.1002299</a>
  chicago: Chevereau, Guillaume, Marta Lukacisinova, Tugce Batur, Aysegul Guvenek,
    Dilay Ayhan, Erdal Toprak, and Mark Tobias Bollenbach. “Quantifying the Determinants
    of Evolutionary Dynamics Leading to Drug Resistance.” <i>PLoS Biology</i>. Public
    Library of Science, 2015. <a href="https://doi.org/10.1371/journal.pbio.1002299">https://doi.org/10.1371/journal.pbio.1002299</a>.
  ieee: G. Chevereau <i>et al.</i>, “Quantifying the determinants of evolutionary
    dynamics leading to drug resistance,” <i>PLoS Biology</i>, vol. 13, no. 11. Public
    Library of Science, 2015.
  ista: Chevereau G, Lukacisinova M, Batur T, Guvenek A, Ayhan D, Toprak E, Bollenbach
    MT. 2015. Quantifying the determinants of evolutionary dynamics leading to drug
    resistance. PLoS Biology. 13(11), e1002299.
  mla: Chevereau, Guillaume, et al. “Quantifying the Determinants of Evolutionary
    Dynamics Leading to Drug Resistance.” <i>PLoS Biology</i>, vol. 13, no. 11, e1002299,
    Public Library of Science, 2015, doi:<a href="https://doi.org/10.1371/journal.pbio.1002299">10.1371/journal.pbio.1002299</a>.
  short: G. Chevereau, M. Lukacisinova, T. Batur, A. Guvenek, D. Ayhan, E. Toprak,
    M.T. Bollenbach, PLoS Biology 13 (2015).
corr_author: '1'
date_created: 2018-12-11T11:53:04Z
date_published: 2015-11-18T00:00:00Z
date_updated: 2026-07-01T22:30:39Z
day: '18'
ddc:
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department:
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doi: 10.1371/journal.pbio.1002299
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title: Quantifying the determinants of evolutionary dynamics leading to drug resistance
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