[{"external_id":{"arxiv":["1907.00261"],"pmid":["31857492"]},"pmid":1,"related_material":{"record":[{"relation":"other","status":"public","id":"10697"},{"status":"public","relation":"other","id":"10698"},{"id":"10699","relation":"other","status":"public"}]},"doi":"10.1126/science.aay5533","author":[{"full_name":"Serlin, M.","last_name":"Serlin","first_name":"M."},{"full_name":"Tschirhart, C. L.","last_name":"Tschirhart","first_name":"C. L."},{"first_name":"Hryhoriy","id":"edfc7cb1-526e-11ec-b05a-e6ecc27e4e48","orcid":"0000-0001-8223-8896","last_name":"Polshyn","full_name":"Polshyn, Hryhoriy"},{"last_name":"Zhang","full_name":"Zhang, Y.","first_name":"Y."},{"last_name":"Zhu","full_name":"Zhu, J.","first_name":"J."},{"last_name":"Watanabe","full_name":"Watanabe, K.","first_name":"K."},{"first_name":"T.","last_name":"Taniguchi","full_name":"Taniguchi, T."},{"full_name":"Balents, L.","last_name":"Balents","first_name":"L."},{"first_name":"A. F.","full_name":"Young, A. F.","last_name":"Young"}],"oa_version":"Preprint","issue":"6480","publication_status":"published","intvolume":"       367","arxiv":1,"extern":"1","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","article_processing_charge":"No","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1907.00261"}],"volume":367,"title":"Intrinsic quantized anomalous Hall effect in a moiré heterostructure","citation":{"mla":"Serlin, M., et al. “Intrinsic Quantized Anomalous Hall Effect in a Moiré Heterostructure.” <i>Science</i>, vol. 367, no. 6480, American Association for the Advancement of Science, 2019, pp. 900–03, doi:<a href=\"https://doi.org/10.1126/science.aay5533\">10.1126/science.aay5533</a>.","ista":"Serlin M, Tschirhart CL, Polshyn H, Zhang Y, Zhu J, Watanabe K, Taniguchi T, Balents L, Young AF. 2019. Intrinsic quantized anomalous Hall effect in a moiré heterostructure. Science. 367(6480), 900–903.","short":"M. Serlin, C.L. Tschirhart, H. Polshyn, Y. Zhang, J. Zhu, K. Watanabe, T. Taniguchi, L. Balents, A.F. Young, Science 367 (2019) 900–903.","apa":"Serlin, M., Tschirhart, C. L., Polshyn, H., Zhang, Y., Zhu, J., Watanabe, K., … Young, A. F. (2019). Intrinsic quantized anomalous Hall effect in a moiré heterostructure. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.aay5533\">https://doi.org/10.1126/science.aay5533</a>","chicago":"Serlin, M., C. L. Tschirhart, Hryhoriy Polshyn, Y. Zhang, J. Zhu, K. Watanabe, T. Taniguchi, L. Balents, and A. F. Young. “Intrinsic Quantized Anomalous Hall Effect in a Moiré Heterostructure.” <i>Science</i>. American Association for the Advancement of Science, 2019. <a href=\"https://doi.org/10.1126/science.aay5533\">https://doi.org/10.1126/science.aay5533</a>.","ieee":"M. Serlin <i>et al.</i>, “Intrinsic quantized anomalous Hall effect in a moiré heterostructure,” <i>Science</i>, vol. 367, no. 6480. American Association for the Advancement of Science, pp. 900–903, 2019.","ama":"Serlin M, Tschirhart CL, Polshyn H, et al. Intrinsic quantized anomalous Hall effect in a moiré heterostructure. <i>Science</i>. 2019;367(6480):900-903. doi:<a href=\"https://doi.org/10.1126/science.aay5533\">10.1126/science.aay5533</a>"},"year":"2019","publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"type":"journal_article","date_updated":"2023-02-21T16:00:09Z","day":"19","date_published":"2019-12-19T00:00:00Z","language":[{"iso":"eng"}],"month":"12","publication":"Science","oa":1,"status":"public","quality_controlled":"1","keyword":["multidisciplinary"],"_id":"10619","page":"900-903","date_created":"2022-01-13T14:21:32Z","scopus_import":"1","article_type":"original","abstract":[{"lang":"eng","text":"The quantum anomalous Hall (QAH) effect combines topology and magnetism to produce precisely quantized Hall resistance at zero magnetic field. We report the observation of a QAH effect in twisted bilayer graphene aligned to hexagonal boron nitride. The effect is driven by intrinsic strong interactions, which polarize the electrons into a single spin- and valley-resolved moiré miniband with Chern number C = 1. In contrast to magnetically doped systems, the measured transport energy gap is larger than the Curie temperature for magnetic ordering, and quantization to within 0.1% of the von Klitzing constant persists to temperatures of several kelvin at zero magnetic field. Electrical currents as small as 1 nanoampere controllably switch the magnetic order between states of opposite polarization, forming an electrically rewritable magnetic memory."}],"acknowledgement":"The authors acknowledge discussions with A. Macdonald, Y. Saito, and M. Zaletel.","publisher":"American Association for the Advancement of Science"},{"abstract":[{"text":"Partially filled Landau levels host competing electronic orders. For example, electron solids may prevail close to integer filling of the Landau levels before giving way to fractional quantum Hall liquids at higher carrier density1,2. Here, we report the observation of an electron solid with non-collinear spin texture in monolayer graphene, consistent with solidification of skyrmions3—topological spin textures characterized by quantized electrical charge4,5. We probe the spin texture of the solids using a modified Corbino geometry that allows ferromagnetic magnons to be launched and detected6,7. We find that magnon transport is highly efficient when one Landau level is filled (ν=1), consistent with quantum Hall ferromagnetic spin polarization. However, even minimal doping immediately quenches the magnon signal while leaving the vanishing low-temperature charge conductivity unchanged. Our results can be understood by the formation of a solid of charged skyrmions near ν=1, whose non-collinear spin texture leads to rapid magnon decay. Data near fractional fillings show evidence of several fractional skyrmion solids, suggesting that graphene hosts a highly tunable landscape of coupled spin and charge orders.","lang":"eng"}],"article_type":"original","acknowledgement":"We acknowledge discussions with B. Halperin, C. Huang, A. Macdonald and M. Zalatel. Experimental work at UCSB was supported by the Army Research Office under awards nos. MURI W911NF-16-1-0361 and W911NF-16-1-0482. K.W. and T.T. acknowledge support from the Elemental Strategy Initiative conducted by MEXT (Japan) and CREST (JPMJCR15F3), JST. A.F.Y. acknowledges the support of the David and Lucile Packard Foundation and and Alfred. P. Sloan Foundation.","publisher":"Springer Nature","keyword":["General Physics and Astronomy"],"scopus_import":"1","date_created":"2022-01-13T14:45:16Z","page":"154-158","_id":"10620","quality_controlled":"1","status":"public","month":"12","publication":"Nature Physics","language":[{"iso":"eng"}],"date_published":"2019-12-16T00:00:00Z","publication_identifier":{"issn":["1745-2473"],"eissn":["1745-2481"]},"year":"2019","type":"journal_article","day":"16","date_updated":"2022-01-13T15:34:44Z","volume":16,"citation":{"apa":"Zhou, H., Polshyn, H., Taniguchi, T., Watanabe, K., &#38; Young, A. F. (2019). Solids of quantum Hall skyrmions in graphene. <i>Nature Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41567-019-0729-8\">https://doi.org/10.1038/s41567-019-0729-8</a>","ama":"Zhou H, Polshyn H, Taniguchi T, Watanabe K, Young AF. Solids of quantum Hall skyrmions in graphene. <i>Nature Physics</i>. 2019;16(2):154-158. doi:<a href=\"https://doi.org/10.1038/s41567-019-0729-8\">10.1038/s41567-019-0729-8</a>","ieee":"H. Zhou, H. Polshyn, T. Taniguchi, K. Watanabe, and A. F. Young, “Solids of quantum Hall skyrmions in graphene,” <i>Nature Physics</i>, vol. 16, no. 2. Springer Nature, pp. 154–158, 2019.","chicago":"Zhou, H., Hryhoriy Polshyn, T. Taniguchi, K. Watanabe, and A. F. Young. “Solids of Quantum Hall Skyrmions in Graphene.” <i>Nature Physics</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1038/s41567-019-0729-8\">https://doi.org/10.1038/s41567-019-0729-8</a>.","mla":"Zhou, H., et al. “Solids of Quantum Hall Skyrmions in Graphene.” <i>Nature Physics</i>, vol. 16, no. 2, Springer Nature, 2019, pp. 154–58, doi:<a href=\"https://doi.org/10.1038/s41567-019-0729-8\">10.1038/s41567-019-0729-8</a>.","ista":"Zhou H, Polshyn H, Taniguchi T, Watanabe K, Young AF. 2019. Solids of quantum Hall skyrmions in graphene. Nature Physics. 16(2), 154–158.","short":"H. Zhou, H. Polshyn, T. Taniguchi, K. Watanabe, A.F. Young, Nature Physics 16 (2019) 154–158."},"title":"Solids of quantum Hall skyrmions in graphene","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No","extern":"1","intvolume":"        16","publication_status":"published","issue":"2","oa_version":"None","doi":"10.1038/s41567-019-0729-8","author":[{"first_name":"H.","last_name":"Zhou","full_name":"Zhou, H."},{"first_name":"Hryhoriy","id":"edfc7cb1-526e-11ec-b05a-e6ecc27e4e48","orcid":"0000-0001-8223-8896","last_name":"Polshyn","full_name":"Polshyn, Hryhoriy"},{"first_name":"T.","full_name":"Taniguchi, T.","last_name":"Taniguchi"},{"first_name":"K.","full_name":"Watanabe, K.","last_name":"Watanabe"},{"full_name":"Young, A. F.","last_name":"Young","first_name":"A. F."}]},{"citation":{"chicago":"Polshyn, Hryhoriy, Matthew Yankowitz, Shaowen Chen, Yuxuan Zhang, K. Watanabe, T. Taniguchi, Cory R. Dean, and Andrea F. Young. “Large Linear-in-Temperature Resistivity in Twisted Bilayer Graphene.” <i>Nature Physics</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1038/s41567-019-0596-3\">https://doi.org/10.1038/s41567-019-0596-3</a>.","apa":"Polshyn, H., Yankowitz, M., Chen, S., Zhang, Y., Watanabe, K., Taniguchi, T., … Young, A. F. (2019). Large linear-in-temperature resistivity in twisted bilayer graphene. <i>Nature Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41567-019-0596-3\">https://doi.org/10.1038/s41567-019-0596-3</a>","ama":"Polshyn H, Yankowitz M, Chen S, et al. Large linear-in-temperature resistivity in twisted bilayer graphene. <i>Nature Physics</i>. 2019;15(10):1011-1016. doi:<a href=\"https://doi.org/10.1038/s41567-019-0596-3\">10.1038/s41567-019-0596-3</a>","ieee":"H. Polshyn <i>et al.</i>, “Large linear-in-temperature resistivity in twisted bilayer graphene,” <i>Nature Physics</i>, vol. 15, no. 10. Springer Nature, pp. 1011–1016, 2019.","ista":"Polshyn H, Yankowitz M, Chen S, Zhang Y, Watanabe K, Taniguchi T, Dean CR, Young AF. 2019. Large linear-in-temperature resistivity in twisted bilayer graphene. Nature Physics. 15(10), 1011–1016.","mla":"Polshyn, Hryhoriy, et al. “Large Linear-in-Temperature Resistivity in Twisted Bilayer Graphene.” <i>Nature Physics</i>, vol. 15, no. 10, Springer Nature, 2019, pp. 1011–16, doi:<a href=\"https://doi.org/10.1038/s41567-019-0596-3\">10.1038/s41567-019-0596-3</a>.","short":"H. Polshyn, M. Yankowitz, S. Chen, Y. Zhang, K. Watanabe, T. Taniguchi, C.R. Dean, A.F. Young, Nature Physics 15 (2019) 1011–1016."},"title":"Large linear-in-temperature resistivity in twisted bilayer graphene","volume":15,"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1902.00763"}],"article_processing_charge":"No","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","language":[{"iso":"eng"}],"date_published":"2019-08-05T00:00:00Z","date_updated":"2022-01-20T09:33:38Z","day":"05","year":"2019","publication_identifier":{"issn":["1745-2473"],"eissn":["1745-2481"]},"type":"journal_article","quality_controlled":"1","oa":1,"status":"public","month":"08","publication":"Nature Physics","publisher":"Springer Nature","article_type":"original","abstract":[{"lang":"eng","text":"Twisted bilayer graphene has recently emerged as a platform for hosting correlated phenomena. For twist angles near θ ≈ 1.1°, the low-energy electronic structure of twisted bilayer graphene features isolated bands with a flat dispersion1,2. Recent experiments have observed a variety of low-temperature phases that appear to be driven by electron interactions, including insulating states, superconductivity and magnetism3,4,5,6. Here we report electrical transport measurements up to room temperature for twist angles varying between 0.75° and 2°. We find that the resistivity, ρ, scales linearly with temperature, T, over a wide range of T before falling again owing to interband activation. The T-linear response is much larger than observed in monolayer graphene for all measured devices, and in particular increases by more than three orders of magnitude in the range where the flat band exists. Our results point to the dominant role of electron–phonon scattering in twisted bilayer graphene, with possible implications for the origin of the observed superconductivity."}],"acknowledgement":"The authors thank S. Das Sarma and F. Wu for sharing their unpublished theoretical results, and acknowledge further discussions with L. Balents and T. Senthil. Work at both Columbia and UCSB was funded by the Army Research Office under award W911NF-17-1-0323. Sample device design and fabrication was partially supported by DoE Pro-QM EFRC (DE-SC0019443). A.F.Y. and C.R.D. separately acknowledge the support of the David and Lucile Packard Foundation. K.W. and T.T. acknowledge support from the Elemental Strategy Initiative conducted by the MEXT, Japan and the CREST (JPMJCR15F3), JST. A portion of this work was carried out at the KITP, Santa Barbara, supported by the National Science Foundation under grant number NSF PHY-1748958.","page":"1011-1016","scopus_import":"1","date_created":"2022-01-13T15:00:58Z","_id":"10621","keyword":["general physics and astronomy"],"external_id":{"arxiv":["1902.00763"]},"oa_version":"Preprint","author":[{"first_name":"Hryhoriy","id":"edfc7cb1-526e-11ec-b05a-e6ecc27e4e48","last_name":"Polshyn","orcid":"0000-0001-8223-8896","full_name":"Polshyn, Hryhoriy"},{"last_name":"Yankowitz","full_name":"Yankowitz, Matthew","first_name":"Matthew"},{"last_name":"Chen","full_name":"Chen, Shaowen","first_name":"Shaowen"},{"last_name":"Zhang","full_name":"Zhang, Yuxuan","first_name":"Yuxuan"},{"first_name":"K.","full_name":"Watanabe, K.","last_name":"Watanabe"},{"first_name":"T.","full_name":"Taniguchi, T.","last_name":"Taniguchi"},{"first_name":"Cory R.","full_name":"Dean, Cory R.","last_name":"Dean"},{"first_name":"Andrea F.","full_name":"Young, Andrea F.","last_name":"Young"}],"doi":"10.1038/s41567-019-0596-3","intvolume":"        15","publication_status":"published","issue":"10","extern":"1","arxiv":1},{"intvolume":"        19","issue":"8","publication_status":"published","arxiv":1,"extern":"1","pmid":1,"external_id":{"pmid":["31246034"],"arxiv":["1905.06303"]},"oa_version":"Preprint","doi":"10.1021/acs.nanolett.9b01983","author":[{"first_name":"Hryhoriy","id":"edfc7cb1-526e-11ec-b05a-e6ecc27e4e48","last_name":"Polshyn","orcid":"0000-0001-8223-8896","full_name":"Polshyn, Hryhoriy"},{"last_name":"Naibert","full_name":"Naibert, Tyler","first_name":"Tyler"},{"last_name":"Budakian","full_name":"Budakian, Raffi","first_name":"Raffi"}],"quality_controlled":"1","month":"06","publication":"Nano Letters","status":"public","oa":1,"abstract":[{"lang":"eng","text":"We demonstrate a method for manipulating small ensembles of vortices in multiply connected superconducting structures. A micron-size magnetic particle attached to the tip of a silicon cantilever is used to locally apply magnetic flux through the superconducting structure. By scanning the tip over the surface of the device and by utilizing the dynamical coupling between the vortices and the cantilever, a high-resolution spatial map of the different vortex configurations is obtained. Moving the tip to a particular location in the map stabilizes a distinct multivortex configuration. Thus, the scanning of the tip over a particular trajectory in space permits nontrivial operations to be performed, such as braiding of individual vortices within a larger vortex ensemble—a key capability required by many proposals for topological quantum computing."}],"article_type":"original","acknowledgement":"We are grateful to Nadya Mason, Taylor Hughes, and Alexey Bezryadin for useful discussions. This work was supported by the DOE Basic Energy Sciences under DE-SC0012649 and the Department of Physics and the Frederick Seitz Materials Research Laboratory Central Facilities at the University of Illinois.","publisher":"American Chemical Society","keyword":["mechanical engineering","condensed matter physics","general materials science","general chemistry","bioengineering"],"_id":"10622","page":"5476-5482","scopus_import":"1","date_created":"2022-01-13T15:11:14Z","volume":19,"title":"Manipulating multivortex states in superconducting structures","citation":{"ista":"Polshyn H, Naibert T, Budakian R. 2019. Manipulating multivortex states in superconducting structures. Nano Letters. 19(8), 5476–5482.","mla":"Polshyn, Hryhoriy, et al. “Manipulating Multivortex States in Superconducting Structures.” <i>Nano Letters</i>, vol. 19, no. 8, American Chemical Society, 2019, pp. 5476–82, doi:<a href=\"https://doi.org/10.1021/acs.nanolett.9b01983\">10.1021/acs.nanolett.9b01983</a>.","short":"H. Polshyn, T. Naibert, R. Budakian, Nano Letters 19 (2019) 5476–5482.","apa":"Polshyn, H., Naibert, T., &#38; Budakian, R. (2019). Manipulating multivortex states in superconducting structures. <i>Nano Letters</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/acs.nanolett.9b01983\">https://doi.org/10.1021/acs.nanolett.9b01983</a>","ieee":"H. Polshyn, T. Naibert, and R. Budakian, “Manipulating multivortex states in superconducting structures,” <i>Nano Letters</i>, vol. 19, no. 8. American Chemical Society, pp. 5476–5482, 2019.","ama":"Polshyn H, Naibert T, Budakian R. Manipulating multivortex states in superconducting structures. <i>Nano Letters</i>. 2019;19(8):5476-5482. doi:<a href=\"https://doi.org/10.1021/acs.nanolett.9b01983\">10.1021/acs.nanolett.9b01983</a>","chicago":"Polshyn, Hryhoriy, Tyler Naibert, and Raffi Budakian. “Manipulating Multivortex States in Superconducting Structures.” <i>Nano Letters</i>. American Chemical Society, 2019. <a href=\"https://doi.org/10.1021/acs.nanolett.9b01983\">https://doi.org/10.1021/acs.nanolett.9b01983</a>."},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No","main_file_link":[{"url":"https://arxiv.org/abs/1905.06303","open_access":"1"}],"date_published":"2019-06-27T00:00:00Z","language":[{"iso":"eng"}],"publication_identifier":{"eissn":["1530-6992"],"issn":["1530-6984"]},"year":"2019","type":"journal_article","date_updated":"2022-01-13T15:41:24Z","day":"27"},{"date_published":"2019-01-24T00:00:00Z","language":[{"iso":"eng"}],"year":"2019","type":"journal_article","publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"date_updated":"2022-01-14T13:48:32Z","day":"24","volume":363,"title":"Tuning superconductivity in twisted bilayer graphene","citation":{"chicago":"Yankowitz, Matthew, Shaowen Chen, Hryhoriy Polshyn, Yuxuan Zhang, K. Watanabe, T. Taniguchi, David Graf, Andrea F. Young, and Cory R. Dean. “Tuning Superconductivity in Twisted Bilayer Graphene.” <i>Science</i>. American Association for the Advancement of Science (AAAS), 2019. <a href=\"https://doi.org/10.1126/science.aav1910\">https://doi.org/10.1126/science.aav1910</a>.","ieee":"M. Yankowitz <i>et al.</i>, “Tuning superconductivity in twisted bilayer graphene,” <i>Science</i>, vol. 363, no. 6431. American Association for the Advancement of Science (AAAS), pp. 1059–1064, 2019.","ama":"Yankowitz M, Chen S, Polshyn H, et al. Tuning superconductivity in twisted bilayer graphene. <i>Science</i>. 2019;363(6431):1059-1064. doi:<a href=\"https://doi.org/10.1126/science.aav1910\">10.1126/science.aav1910</a>","apa":"Yankowitz, M., Chen, S., Polshyn, H., Zhang, Y., Watanabe, K., Taniguchi, T., … Dean, C. R. (2019). Tuning superconductivity in twisted bilayer graphene. <i>Science</i>. American Association for the Advancement of Science (AAAS). <a href=\"https://doi.org/10.1126/science.aav1910\">https://doi.org/10.1126/science.aav1910</a>","short":"M. Yankowitz, S. Chen, H. Polshyn, Y. Zhang, K. Watanabe, T. Taniguchi, D. Graf, A.F. Young, C.R. Dean, Science 363 (2019) 1059–1064.","mla":"Yankowitz, Matthew, et al. “Tuning Superconductivity in Twisted Bilayer Graphene.” <i>Science</i>, vol. 363, no. 6431, American Association for the Advancement of Science (AAAS), 2019, pp. 1059–64, doi:<a href=\"https://doi.org/10.1126/science.aav1910\">10.1126/science.aav1910</a>.","ista":"Yankowitz M, Chen S, Polshyn H, Zhang Y, Watanabe K, Taniguchi T, Graf D, Young AF, Dean CR. 2019. Tuning superconductivity in twisted bilayer graphene. Science. 363(6431), 1059–1064."},"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","article_processing_charge":"No","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1808.07865"}],"acknowledgement":"We thank J. Zhu and H. Zhou for experimental assistance and D. Shahar, A. Millis, O. Vafek, M. Zaletel, L. Balents, C. Xu, A. Bernevig, L. Fu, M. Koshino, and P. Moon for helpful discussions.","article_type":"original","abstract":[{"lang":"eng","text":"The discovery of superconductivity and exotic insulating phases in twisted bilayer graphene has established this material as a model system of strongly correlated electrons. To achieve superconductivity, the two layers of graphene need to be at a very precise angle with respect to each other. Yankowitz et al. now show that another experimental knob, hydrostatic pressure, can be used to tune the phase diagram of twisted bilayer graphene (see the Perspective by Feldman). Applying pressure increased the coupling between the layers, which shifted the superconducting transition to higher angles and somewhat higher temperatures."}],"publisher":"American Association for the Advancement of Science (AAAS)","keyword":["multidisciplinary"],"_id":"10625","page":"1059-1064","date_created":"2022-01-14T12:14:58Z","scopus_import":"1","quality_controlled":"1","publication":"Science","month":"01","oa":1,"status":"public","oa_version":"Preprint","doi":"10.1126/science.aav1910","author":[{"first_name":"Matthew","last_name":"Yankowitz","full_name":"Yankowitz, Matthew"},{"full_name":"Chen, Shaowen","last_name":"Chen","first_name":"Shaowen"},{"first_name":"Hryhoriy","id":"edfc7cb1-526e-11ec-b05a-e6ecc27e4e48","last_name":"Polshyn","orcid":"0000-0001-8223-8896","full_name":"Polshyn, Hryhoriy"},{"first_name":"Yuxuan","last_name":"Zhang","full_name":"Zhang, Yuxuan"},{"first_name":"K.","last_name":"Watanabe","full_name":"Watanabe, K."},{"last_name":"Taniguchi","full_name":"Taniguchi, T.","first_name":"T."},{"last_name":"Graf","full_name":"Graf, David","first_name":"David"},{"last_name":"Young","full_name":"Young, Andrea F.","first_name":"Andrea F."},{"full_name":"Dean, Cory R.","last_name":"Dean","first_name":"Cory R."}],"pmid":1,"external_id":{"pmid":["30679385 "],"arxiv":["1808.07865"]},"arxiv":1,"extern":"1","intvolume":"       363","issue":"6431","publication_status":"published"},{"publication_status":"published","status":"public","oa":1,"publication":"Journal Club for Condensed Matter Physics","month":"02","quality_controlled":"1","intvolume":"         3","date_created":"2022-01-25T15:09:58Z","_id":"10664","abstract":[{"text":"Since the discovery of correlated insulators and superconductivity in magic-angle twisted bilayer graphene (tBLG) ([1, 2], JCCM April 2018), theorists have been excitedly pursuing the alluring mix of band topology, symmetry breaking, Mott insulators and superconductivity at play, as well as the potential relation (if any) to high-Tc physics. Now a new stream\r\nof experimental work is arriving which further enriches the story. To briefly recap Episodes 1 and 2 (JCCM April and November 2018), when two graphene layers are stacked with a small rotational mismatch θ, the resulting long-wavelength moire pattern leads to a superlattice potential which reconstructs the low energy band structure. When θ approaches the “magic-angle” θM ∼ 1 ◦, the band structure features eight nearly-flat bands which fill when the electron number per moire unit cell, n/n0, lies between −4 < n/n0 < 4. The bands can be counted as 8 = 2 × 2 × 2: for each spin (2×) and valley (2×) characteristic of monolayergraphene, tBLG has has 2× flat bands which cross at mini-Dirac points.","lang":"eng"}],"article_type":"original","extern":"1","publisher":"Simons Foundation ; University of California, Riverside","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","main_file_link":[{"url":"https://www.condmatjclub.org/?p=3541","open_access":"1"}],"article_processing_charge":"No","volume":"03","citation":{"mla":"Yankowitz, Mathew, et al. “New Correlated Phenomena in Magic-Angle Twisted Bilayer Graphene/S.” <i>Journal Club for Condensed Matter Physics</i>, vol. 03, Simons Foundation ; University of California, Riverside, 2019, doi:<a href=\"https://doi.org/10.36471/jccm_february_2019_03\">10.36471/jccm_february_2019_03</a>.","ista":"Yankowitz M, Chen S, Polshyn H, Watanabe K, Taniguchi T, Graf D, Young AF, Dean CR, Sharpe AL, Fox EJ, Barnard AW, Finney J. 2019. New correlated phenomena in magic-angle twisted bilayer graphene/s. Journal Club for Condensed Matter Physics. 03.","short":"M. Yankowitz, S. Chen, H. Polshyn, K. Watanabe, T. Taniguchi, D. Graf, A.F. Young, C.R. Dean, A.L. Sharpe, E.J. Fox, A.W. Barnard, J. Finney, Journal Club for Condensed Matter Physics 03 (2019).","ieee":"M. Yankowitz <i>et al.</i>, “New correlated phenomena in magic-angle twisted bilayer graphene/s,” <i>Journal Club for Condensed Matter Physics</i>, vol. 03. Simons Foundation ; University of California, Riverside, 2019.","apa":"Yankowitz, M., Chen, S., Polshyn, H., Watanabe, K., Taniguchi, T., Graf, D., … Finney, J. (2019). New correlated phenomena in magic-angle twisted bilayer graphene/s. <i>Journal Club for Condensed Matter Physics</i>. Simons Foundation ; University of California, Riverside. <a href=\"https://doi.org/10.36471/jccm_february_2019_03\">https://doi.org/10.36471/jccm_february_2019_03</a>","chicago":"Yankowitz, Mathew, Shaowen Chen, Hryhoriy Polshyn, K. Watanabe, T. Taniguchi, David Graf, Andrea F. Young, et al. “New Correlated Phenomena in Magic-Angle Twisted Bilayer Graphene/S.” <i>Journal Club for Condensed Matter Physics</i>. Simons Foundation ; University of California, Riverside, 2019. <a href=\"https://doi.org/10.36471/jccm_february_2019_03\">https://doi.org/10.36471/jccm_february_2019_03</a>.","ama":"Yankowitz M, Chen S, Polshyn H, et al. New correlated phenomena in magic-angle twisted bilayer graphene/s. <i>Journal Club for Condensed Matter Physics</i>. 2019;03. doi:<a href=\"https://doi.org/10.36471/jccm_february_2019_03\">10.36471/jccm_february_2019_03</a>"},"title":"New correlated phenomena in magic-angle twisted bilayer graphene/s","type":"journal_article","year":"2019","doi":"10.36471/jccm_february_2019_03","date_updated":"2025-01-14T14:28:17Z","author":[{"first_name":"Mathew","last_name":"Yankowitz","full_name":"Yankowitz, Mathew"},{"first_name":"Shaowen","full_name":"Chen, Shaowen","last_name":"Chen"},{"orcid":"0000-0001-8223-8896","last_name":"Polshyn","full_name":"Polshyn, Hryhoriy","first_name":"Hryhoriy","id":"edfc7cb1-526e-11ec-b05a-e6ecc27e4e48"},{"last_name":"Watanabe","full_name":"Watanabe, K.","first_name":"K."},{"first_name":"T.","last_name":"Taniguchi","full_name":"Taniguchi, T."},{"full_name":"Graf, David","last_name":"Graf","first_name":"David"},{"full_name":"Young, Andrea F.","last_name":"Young","first_name":"Andrea F."},{"first_name":"Cory R.","last_name":"Dean","full_name":"Dean, Cory R."},{"first_name":"Aaron L.","last_name":"Sharpe","full_name":"Sharpe, Aaron L."},{"full_name":"Fox, E.J.","last_name":"Fox","first_name":"E.J."},{"full_name":"Barnard, A.W.","last_name":"Barnard","first_name":"A.W."},{"last_name":"Finney","full_name":"Finney, Joe","first_name":"Joe"}],"day":"28","date_published":"2019-02-28T00:00:00Z","language":[{"iso":"eng"}],"oa_version":"Published Version"},{"day":"01","date_updated":"2022-02-08T10:25:30Z","year":"2019","type":"conference","publication_identifier":{"issn":["0003-0503"]},"language":[{"iso":"eng"}],"date_published":"2019-03-01T00:00:00Z","main_file_link":[{"url":"https://meetings.aps.org/Meeting/MAR19/Session/L14.6","open_access":"1"}],"article_processing_charge":"No","conference":{"start_date":"2019-03-04","end_date":"2019-03-08","name":"APS: American Physical Society","location":"Boston, MA, United States"},"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","title":"Direct Imaging of magnetic structure in twisted bilayer graphene with scanning nanoSQUID-On-Tip microscopy","citation":{"ieee":"M. Serlin, C. Tschirhart, H. Polshyn, J. Zhu, M. E. Huber, and A. Young, “Direct Imaging of magnetic structure in twisted bilayer graphene with scanning nanoSQUID-On-Tip microscopy,” in <i>APS March Meeting 2019</i>, Boston, MA, United States, 2019, vol. 64, no. 2.","chicago":"Serlin, Marec, Charles Tschirhart, Hryhoriy Polshyn, Jiacheng Zhu, Martin E. Huber, and Andrea Young. “Direct Imaging of Magnetic Structure in Twisted Bilayer Graphene with Scanning NanoSQUID-On-Tip Microscopy.” In <i>APS March Meeting 2019</i>, Vol. 64. American Physical Society, 2019.","apa":"Serlin, M., Tschirhart, C., Polshyn, H., Zhu, J., Huber, M. E., &#38; Young, A. (2019). Direct Imaging of magnetic structure in twisted bilayer graphene with scanning nanoSQUID-On-Tip microscopy. In <i>APS March Meeting 2019</i> (Vol. 64). Boston, MA, United States: American Physical Society.","ama":"Serlin M, Tschirhart C, Polshyn H, Zhu J, Huber ME, Young A. Direct Imaging of magnetic structure in twisted bilayer graphene with scanning nanoSQUID-On-Tip microscopy. In: <i>APS March Meeting 2019</i>. Vol 64. American Physical Society; 2019.","short":"M. Serlin, C. Tschirhart, H. Polshyn, J. Zhu, M.E. Huber, A. Young, in:, APS March Meeting 2019, American Physical Society, 2019.","mla":"Serlin, Marec, et al. “Direct Imaging of Magnetic Structure in Twisted Bilayer Graphene with Scanning NanoSQUID-On-Tip Microscopy.” <i>APS March Meeting 2019</i>, vol. 64, no. 2, L14.00006, American Physical Society, 2019.","ista":"Serlin M, Tschirhart C, Polshyn H, Zhu J, Huber ME, Young A. 2019. Direct Imaging of magnetic structure in twisted bilayer graphene with scanning nanoSQUID-On-Tip microscopy. APS March Meeting 2019. APS: American Physical Society, Bulletin of the American Physical Society, vol. 64, L14.00006."},"volume":64,"_id":"10722","date_created":"2022-02-04T11:54:21Z","publisher":"American Physical Society","abstract":[{"text":"Bilayer graphene, rotationally faulted to ~1.1 degree misalignment, has recently been shown to host superconducting and resistive states associated with the formation of a flat electronic band. While numerous theories exist for the origins of both states, direct validation of these theories remains an outstanding experimental problem. Here, we focus on the resistive states occurring at commensurate filling (1/2, 1/4, and 3/4) of the two lowest superlattice bands. We test theoretical proposals that these states arise due to broken spin—and/or valley—symmetry by performing direct magnetic imaging with nanoscale SQUID-on-tip microscopy. This technique provides single-spin resolved magnetometry on sub-100nm length scales. I will present imaging data from our 4.2K nSOT microscope on graphite-gated twisted bilayers near the flat band condition and discuss the implications for the physics of the commensurate resistive states.","lang":"eng"}],"month":"03","publication":"APS March Meeting 2019","status":"public","oa":1,"quality_controlled":"1","author":[{"first_name":"Marec","last_name":"Serlin","full_name":"Serlin, Marec"},{"last_name":"Tschirhart","full_name":"Tschirhart, Charles","first_name":"Charles"},{"id":"edfc7cb1-526e-11ec-b05a-e6ecc27e4e48","first_name":"Hryhoriy","full_name":"Polshyn, Hryhoriy","orcid":"0000-0001-8223-8896","last_name":"Polshyn"},{"first_name":"Jiacheng","last_name":"Zhu","full_name":"Zhu, Jiacheng"},{"first_name":"Martin E.","last_name":"Huber","full_name":"Huber, Martin E."},{"last_name":"Young","full_name":"Young, Andrea","first_name":"Andrea"}],"oa_version":"Published Version","extern":"1","alternative_title":["Bulletin of the American Physical Society"],"issue":"2","publication_status":"published","article_number":"L14.00006","intvolume":"        64"},{"article_processing_charge":"No","main_file_link":[{"url":"https://meetings.aps.org/Meeting/MAR19/Session/P01.4","open_access":"1"}],"conference":{"name":"APS: American Physical Society","end_date":"2019-03-08","location":"Boston, MA, United States","start_date":"2019-03-04"},"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","title":"Spin wave transport through electron solids and fractional quantum Hall liquids in graphene","citation":{"chicago":"Zhou, Haoxin, Hryhoriy Polshyn, Takashi Tanaguchi, Kenji Watanabe, and Andrea Young. “Spin Wave Transport through Electron Solids and Fractional Quantum Hall Liquids in Graphene.” In <i>APS March Meeting 2019</i>, Vol. 64. American Physical Society, 2019.","apa":"Zhou, H., Polshyn, H., Tanaguchi, T., Watanabe, K., &#38; Young, A. (2019). Spin wave transport through electron solids and fractional quantum Hall liquids in graphene. In <i>APS March Meeting 2019</i> (Vol. 64). Boston, MA, United States: American Physical Society.","ama":"Zhou H, Polshyn H, Tanaguchi T, Watanabe K, Young A. Spin wave transport through electron solids and fractional quantum Hall liquids in graphene. In: <i>APS March Meeting 2019</i>. Vol 64. American Physical Society; 2019.","ieee":"H. Zhou, H. Polshyn, T. Tanaguchi, K. Watanabe, and A. Young, “Spin wave transport through electron solids and fractional quantum Hall liquids in graphene,” in <i>APS March Meeting 2019</i>, Boston, MA, United States, 2019, vol. 64, no. 2.","short":"H. Zhou, H. Polshyn, T. Tanaguchi, K. Watanabe, A. Young, in:, APS March Meeting 2019, American Physical Society, 2019.","ista":"Zhou H, Polshyn H, Tanaguchi T, Watanabe K, Young A. 2019. Spin wave transport through electron solids and fractional quantum Hall liquids in graphene. APS March Meeting 2019. APS: American Physical Society vol. 64, P01.00004.","mla":"Zhou, Haoxin, et al. “Spin Wave Transport through Electron Solids and Fractional Quantum Hall Liquids in Graphene.” <i>APS March Meeting 2019</i>, vol. 64, no. 2, P01.00004, American Physical Society, 2019."},"volume":64,"author":[{"last_name":"Zhou","full_name":"Zhou, Haoxin","first_name":"Haoxin"},{"full_name":"Polshyn, Hryhoriy","last_name":"Polshyn","orcid":"0000-0001-8223-8896","id":"edfc7cb1-526e-11ec-b05a-e6ecc27e4e48","first_name":"Hryhoriy"},{"full_name":"Tanaguchi, Takashi","last_name":"Tanaguchi","first_name":"Takashi"},{"last_name":"Watanabe","full_name":"Watanabe, Kenji","first_name":"Kenji"},{"last_name":"Young","full_name":"Young, Andrea","first_name":"Andrea"}],"date_updated":"2022-02-04T13:59:47Z","day":"01","publication_identifier":{"issn":["0003-0503"]},"type":"conference","year":"2019","oa_version":"Published Version","language":[{"iso":"eng"}],"date_published":"2019-03-01T00:00:00Z","month":"03","publication":"APS March Meeting 2019","status":"public","oa":1,"issue":"2","publication_status":"published","article_number":"P01.00004","intvolume":"        64","quality_controlled":"1","_id":"10723","date_created":"2022-02-04T12:14:02Z","extern":"1","publisher":"American Physical Society","abstract":[{"text":"In monolayer graphene, the interplay of electronic correlations with the internal spin- and valley- degrees of freedom leads to a complex phase diagram of isospin symmetry breaking at high magnetic fields. Recently, Wei et al. (Science (2018)) demonstrated that spin waves can be electrically generated and detected in graphene heterojunctions, allowing direct experiment access to the spin degree of freedom. Here, we apply this technique to high quality graphite-gated graphene devices showing robust fractional quantum Hall phases and isospin phase transitions. We use an edgeless Corbino geometry to eliminate the contributions of edge states to the spin-wave mediated nonlocal voltage, allowing unambiguous identification of spin wave transport signatures. Our data reveal two phases within the ν = 1 plateau. For exactly ν=1, charge is localized but spin waves propagate freely while small carrier doping completely quenches the low-energy spin-wave transport, even as those charges remain localized. We identify this new phase as a spin textured electron solid. We also find that spin-wave transport is modulated by phase transitions in the valley order that preserve spin polarization, suggesting that this technique is sensitive to both spin and valley order.","lang":"eng"}]},{"abstract":[{"text":"Twisted bilayer graphene (tBLG) near the flat band condition is a versatile new platform for the study of correlated physics in 2D. Resistive states have been observed at several commensurate fillings of the flat miniband, along with superconducting states near half filling. To better understand the electronic structure of this system, we study electronic transport of graphite gated superconducting tBLG devices in the normal regime. At high magnetic fields, we observe full lifting of the spin and valley degeneracy. The transitions in the splitting of this four-fold degeneracy as a function of carrier density indicate Landau level (LL) crossings, which tilted field measurements show occur between LLs with different valley polarization. Similar LL structure measured in two devices, one with twist angle θ=1.08° at ambient pressure and one at θ=1.27° and 1.33GPa, suggests that the dimensionless combination of twist angle and interlayer coupling controls the relevant details of the band structure. In addition, we find that the temperature dependence of the resistance at B=0 shows linear growth at several hundred Ohm/K in a broad range of temperatures. We discuss the implications for modeling the scattering processes in this system.","lang":"eng"}],"publisher":"American Physical Society","_id":"10724","date_created":"2022-02-04T12:25:04Z","quality_controlled":"1","publication":"APS March Meeting 2019","month":"03","oa":1,"status":"public","language":[{"iso":"eng"}],"date_published":"2019-03-01T00:00:00Z","type":"conference","publication_identifier":{"issn":["0003-0503"]},"year":"2019","day":"01","date_updated":"2022-02-08T10:23:13Z","volume":64,"title":"Normal state transport in superconducting twisted bilayer graphene","citation":{"apa":"Polshyn, H., Zhang, Y., Yankowitz, M., Chen, S., Taniguchi, T., Watanabe, K., … Young, A. (2019). Normal state transport in superconducting twisted bilayer graphene. In <i>APS March Meeting 2019</i> (Vol. 64). Boston, MA, United States: American Physical Society.","ama":"Polshyn H, Zhang Y, Yankowitz M, et al. Normal state transport in superconducting twisted bilayer graphene. In: <i>APS March Meeting 2019</i>. Vol 64. American Physical Society; 2019.","ieee":"H. Polshyn <i>et al.</i>, “Normal state transport in superconducting twisted bilayer graphene,” in <i>APS March Meeting 2019</i>, Boston, MA, United States, 2019, vol. 64, no. 2.","chicago":"Polshyn, Hryhoriy, Yuxuan Zhang, Matthew Yankowitz, Shaowen Chen, Takashi Taniguchi, Kenji Watanabe, David E. Graf, Cory R. Dean, and Andrea Young. “Normal State Transport in Superconducting Twisted Bilayer Graphene.” In <i>APS March Meeting 2019</i>, Vol. 64. American Physical Society, 2019.","short":"H. Polshyn, Y. Zhang, M. Yankowitz, S. Chen, T. Taniguchi, K. Watanabe, D.E. Graf, C.R. Dean, A. Young, in:, APS March Meeting 2019, American Physical Society, 2019.","mla":"Polshyn, Hryhoriy, et al. “Normal State Transport in Superconducting Twisted Bilayer Graphene.” <i>APS March Meeting 2019</i>, vol. 64, no. 2, V14.00008, American Physical Society, 2019.","ista":"Polshyn H, Zhang Y, Yankowitz M, Chen S, Taniguchi T, Watanabe K, Graf DE, Dean CR, Young A. 2019. Normal state transport in superconducting twisted bilayer graphene. APS March Meeting 2019. APS: American Physical Society, Bulletin of the American Physical Society, vol. 64, V14.00008."},"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","main_file_link":[{"url":"https://meetings.aps.org/Meeting/MAR19/Session/V14.8","open_access":"1"}],"article_processing_charge":"No","conference":{"name":"APS: American Physical Society","end_date":"2019-03-08","location":"Boston, MA, United States","start_date":"2019-03-04"},"extern":"1","intvolume":"        64","alternative_title":["Bulletin of the American Physical Society"],"issue":"2","article_number":"V14.00008","publication_status":"published","oa_version":"Published Version","author":[{"id":"edfc7cb1-526e-11ec-b05a-e6ecc27e4e48","first_name":"Hryhoriy","full_name":"Polshyn, Hryhoriy","orcid":"0000-0001-8223-8896","last_name":"Polshyn"},{"first_name":"Yuxuan","full_name":"Zhang, Yuxuan","last_name":"Zhang"},{"first_name":"Matthew","full_name":"Yankowitz, Matthew","last_name":"Yankowitz"},{"first_name":"Shaowen","full_name":"Chen, Shaowen","last_name":"Chen"},{"first_name":"Takashi","full_name":"Taniguchi, Takashi","last_name":"Taniguchi"},{"last_name":"Watanabe","full_name":"Watanabe, Kenji","first_name":"Kenji"},{"full_name":"Graf, David E.","last_name":"Graf","first_name":"David E."},{"first_name":"Cory R.","full_name":"Dean, Cory R.","last_name":"Dean"},{"first_name":"Andrea","full_name":"Young, Andrea","last_name":"Young"}]},{"quality_controlled":"1","oa":1,"status":"public","month":"03","publication":"APS March Meeting 2019","abstract":[{"text":"Bilayer graphene with ~ 1.1 degrees twist mismatch between the layers hosts a low energy flat band in which the Coulomb interaction is large relative to the bandwidth, promoting correlated insulating states at half band filling, and superconducting (SC) phases with dome-like structure neighboring correlated insulating states. Here we show measurements of a dual-graphite-gated twisted bilayer graphene device, which minimizes charge inhomogeneity. We observe new correlated phases, including for the first time a SC pocket near half-filling of the electron-doped band and resistive states at quarter-filling of both bands that emerge in a magnetic field. Changing the layer polarization with vertical electric field reveals an unexpected competition between SC and correlated insulator phases, which we interpret to result from differences in disorder of each graphene layer and underscores the spatial inhomogeneity like twist angle as a significant source of disorder in these devices [1].","lang":"eng"}],"publisher":"American Physical Society","date_created":"2022-02-04T13:48:04Z","_id":"10725","volume":64,"citation":{"mla":"Chen, Shaowen, et al. “Correlated Insulating and Superconducting Phases in Twisted Bilayer Graphene.” <i>APS March Meeting 2019</i>, vol. 64, no. 2, R14.00004, American Physical Society, 2019.","ista":"Chen S, Yankowitz M, Polshyn H, Watanabe K, Taniguchi T, Graf DE, Young A, Dean CR. 2019. Correlated insulating and superconducting phases in twisted bilayer graphene. APS March Meeting 2019. APS: American Physical Society, Bulletin of the American Physical Society, vol. 64, R14.00004.","short":"S. Chen, M. Yankowitz, H. Polshyn, K. Watanabe, T. Taniguchi, D.E. Graf, A. Young, C.R. Dean, in:, APS March Meeting 2019, American Physical Society, 2019.","chicago":"Chen, Shaowen, Matthew Yankowitz, Hryhoriy Polshyn, Kenji Watanabe, Takashi Taniguchi, David E. Graf, Andrea Young, and Cory R. Dean. “Correlated Insulating and Superconducting Phases in Twisted Bilayer Graphene.” In <i>APS March Meeting 2019</i>, Vol. 64. American Physical Society, 2019.","apa":"Chen, S., Yankowitz, M., Polshyn, H., Watanabe, K., Taniguchi, T., Graf, D. E., … Dean, C. R. (2019). Correlated insulating and superconducting phases in twisted bilayer graphene. In <i>APS March Meeting 2019</i> (Vol. 64). Boston, MA, United States: American Physical Society.","ama":"Chen S, Yankowitz M, Polshyn H, et al. Correlated insulating and superconducting phases in twisted bilayer graphene. In: <i>APS March Meeting 2019</i>. Vol 64. American Physical Society; 2019.","ieee":"S. Chen <i>et al.</i>, “Correlated insulating and superconducting phases in twisted bilayer graphene,” in <i>APS March Meeting 2019</i>, Boston, MA, United States, 2019, vol. 64, no. 2."},"title":"Correlated insulating and superconducting phases in twisted bilayer graphene","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","conference":{"start_date":"2019-03-04","location":"Boston, MA, United States","name":"APS: American Physical Society","end_date":"2019-03-08"},"main_file_link":[{"url":"https://meetings.aps.org/Meeting/MAR19/Session/R14.4","open_access":"1"}],"article_processing_charge":"No","language":[{"iso":"eng"}],"date_published":"2019-03-01T00:00:00Z","year":"2019","type":"conference","publication_identifier":{"issn":["0003-0503"]},"day":"01","date_updated":"2022-02-08T10:24:13Z","intvolume":"        64","publication_status":"published","article_number":"R14.00004","issue":"2","alternative_title":["Bulletin of the American Physical Society"],"extern":"1","related_material":{"link":[{"relation":"used_in_publication","url":"https://arxiv.org/abs/1808.07865"}]},"oa_version":"Published Version","author":[{"first_name":"Shaowen","last_name":"Chen","full_name":"Chen, Shaowen"},{"first_name":"Matthew","full_name":"Yankowitz, Matthew","last_name":"Yankowitz"},{"first_name":"Hryhoriy","id":"edfc7cb1-526e-11ec-b05a-e6ecc27e4e48","orcid":"0000-0001-8223-8896","last_name":"Polshyn","full_name":"Polshyn, Hryhoriy"},{"first_name":"Kenji","last_name":"Watanabe","full_name":"Watanabe, Kenji"},{"last_name":"Taniguchi","full_name":"Taniguchi, Takashi","first_name":"Takashi"},{"first_name":"David E.","full_name":"Graf, David E.","last_name":"Graf"},{"last_name":"Young","full_name":"Young, Andrea","first_name":"Andrea"},{"first_name":"Cory R.","last_name":"Dean","full_name":"Dean, Cory R."}]},{"publisher":"EasyChair","abstract":[{"lang":"eng","text":"We present the results of a friendly competition for formal verification of continuous and hybrid systems with nonlinear continuous dynamics. The friendly competition took place as part of the workshop Applied Verification for Continuous and Hybrid Systems (ARCH) in 2019. In this year, 6 tools Ariadne, CORA, DynIbex, Flow*, Isabelle/HOL, and JuliaReach (in alphabetic order) participated. They are applied to solve reachability analysis problems on four benchmark problems, one of them with hybrid dynamics. We do not rank the tools based on the results, but show the current status and discover the potential advantages of different tools."}],"_id":"7576","date_created":"2020-03-08T23:00:49Z","scopus_import":"1","page":"41-61","quality_controlled":"1","ddc":["000"],"publication":"EPiC Series in Computing","month":"05","oa":1,"status":"public","corr_author":"1","date_published":"2019-05-25T00:00:00Z","language":[{"iso":"eng"}],"has_accepted_license":"1","department":[{"_id":"ToHe"}],"file_date_updated":"2020-07-14T12:48:00Z","date_updated":"2026-04-03T09:51:13Z","day":"25","type":"conference","publication_identifier":{"eissn":["2398-7340"]},"year":"2019","title":"ARCH-COMP19 Category Report: Continuous and hybrid systems with nonlinear dynamics","citation":{"short":"F. Immler, M. Althoff, L. Benet, A. Chapoutot, X. Chen, M. Forets, L. Geretti, N. Kochdumper, D.P. Sanders, C. Schilling, in:, EPiC Series in Computing, EasyChair, 2019, pp. 41–61.","mla":"Immler, Fabian, et al. “ARCH-COMP19 Category Report: Continuous and Hybrid Systems with Nonlinear Dynamics.” <i>EPiC Series in Computing</i>, vol. 61, EasyChair, 2019, pp. 41–61, doi:<a href=\"https://doi.org/10.29007/m75b\">10.29007/m75b</a>.","ista":"Immler F, Althoff M, Benet L, Chapoutot A, Chen X, Forets M, Geretti L, Kochdumper N, Sanders DP, Schilling C. 2019. ARCH-COMP19 Category Report: Continuous and hybrid systems with nonlinear dynamics. EPiC Series in Computing. ARCH: International Workshop on Applied Verification on Continuous and Hybrid Systems vol. 61, 41–61.","ieee":"F. Immler <i>et al.</i>, “ARCH-COMP19 Category Report: Continuous and hybrid systems with nonlinear dynamics,” in <i>EPiC Series in Computing</i>, Montreal, Canada, 2019, vol. 61, pp. 41–61.","chicago":"Immler, Fabian, Matthias Althoff, Luis Benet, Alexandre Chapoutot, Xin Chen, Marcelo Forets, Luca Geretti, Niklas Kochdumper, David P. Sanders, and Christian Schilling. “ARCH-COMP19 Category Report: Continuous and Hybrid Systems with Nonlinear Dynamics.” In <i>EPiC Series in Computing</i>, 61:41–61. EasyChair, 2019. <a href=\"https://doi.org/10.29007/m75b\">https://doi.org/10.29007/m75b</a>.","ama":"Immler F, Althoff M, Benet L, et al. ARCH-COMP19 Category Report: Continuous and hybrid systems with nonlinear dynamics. In: <i>EPiC Series in Computing</i>. Vol 61. EasyChair; 2019:41-61. doi:<a href=\"https://doi.org/10.29007/m75b\">10.29007/m75b</a>","apa":"Immler, F., Althoff, M., Benet, L., Chapoutot, A., Chen, X., Forets, M., … Schilling, C. (2019). ARCH-COMP19 Category Report: Continuous and hybrid systems with nonlinear dynamics. In <i>EPiC Series in Computing</i> (Vol. 61, pp. 41–61). Montreal, Canada: EasyChair. <a href=\"https://doi.org/10.29007/m75b\">https://doi.org/10.29007/m75b</a>"},"volume":61,"article_processing_charge":"No","conference":{"name":"ARCH: International Workshop on Applied Verification on Continuous and Hybrid Systems","end_date":"2019-04-15","location":"Montreal, Canada","start_date":"2019-04-15"},"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","intvolume":"        61","publication_status":"published","oa_version":"Published Version","file":[{"checksum":"9138977a06fcd6a95976eb4bca875f0c","file_size":1934830,"content_type":"application/pdf","file_id":"7617","relation":"main_file","access_level":"open_access","date_created":"2020-03-24T07:36:36Z","date_updated":"2020-07-14T12:48:00Z","creator":"dernst","file_name":"2019_ARCH19_Immler.pdf"}],"author":[{"last_name":"Immler","full_name":"Immler, Fabian","first_name":"Fabian"},{"first_name":"Matthias","full_name":"Althoff, Matthias","last_name":"Althoff"},{"full_name":"Benet, Luis","last_name":"Benet","first_name":"Luis"},{"last_name":"Chapoutot","full_name":"Chapoutot, Alexandre","first_name":"Alexandre"},{"last_name":"Chen","full_name":"Chen, Xin","first_name":"Xin"},{"first_name":"Marcelo","last_name":"Forets","full_name":"Forets, Marcelo"},{"last_name":"Geretti","full_name":"Geretti, Luca","first_name":"Luca"},{"first_name":"Niklas","full_name":"Kochdumper, Niklas","last_name":"Kochdumper"},{"last_name":"Sanders","full_name":"Sanders, David P.","first_name":"David P."},{"id":"3A2F4DCE-F248-11E8-B48F-1D18A9856A87","first_name":"Christian","full_name":"Schilling, Christian","last_name":"Schilling","orcid":"0000-0003-3658-1065"}],"doi":"10.29007/m75b"},{"external_id":{"arxiv":["1812.01475"],"isi":["000540384500015"]},"related_material":{"record":[{"status":"public","relation":"dissertation_contains","id":"15020"}]},"doi":"10.1109/ITW44776.2019.8989292","author":[{"id":"4171253A-F248-11E8-B48F-1D18A9856A87","first_name":"Michal","full_name":"Hledik, Michal","last_name":"Hledik"},{"orcid":"0000-0002-1287-3779","last_name":"Sokolowski","full_name":"Sokolowski, Thomas R","first_name":"Thomas R","id":"3E999752-F248-11E8-B48F-1D18A9856A87"},{"id":"3D494DCA-F248-11E8-B48F-1D18A9856A87","first_name":"Gašper","full_name":"Tkačik, Gašper","last_name":"Tkačik","orcid":"0000-0002-6699-1455"}],"oa_version":"Preprint","article_number":"8989292","publication_status":"published","arxiv":1,"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","conference":{"name":"Information Theory Workshop","end_date":"2019-08-28","location":"Visby, Sweden","start_date":"2019-08-25"},"main_file_link":[{"url":"https://arxiv.org/abs/1812.01475","open_access":"1"}],"article_processing_charge":"No","project":[{"grant_number":"665385","name":"International IST Doctoral Program","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"}],"citation":{"apa":"Hledik, M., Sokolowski, T. R., &#38; Tkačik, G. (2019). A tight upper bound on mutual information. In <i>IEEE Information Theory Workshop, ITW 2019</i>. Visby, Sweden: IEEE. <a href=\"https://doi.org/10.1109/ITW44776.2019.8989292\">https://doi.org/10.1109/ITW44776.2019.8989292</a>","chicago":"Hledik, Michal, Thomas R Sokolowski, and Gašper Tkačik. “A Tight Upper Bound on Mutual Information.” In <i>IEEE Information Theory Workshop, ITW 2019</i>. IEEE, 2019. <a href=\"https://doi.org/10.1109/ITW44776.2019.8989292\">https://doi.org/10.1109/ITW44776.2019.8989292</a>.","ama":"Hledik M, Sokolowski TR, Tkačik G. A tight upper bound on mutual information. In: <i>IEEE Information Theory Workshop, ITW 2019</i>. IEEE; 2019. doi:<a href=\"https://doi.org/10.1109/ITW44776.2019.8989292\">10.1109/ITW44776.2019.8989292</a>","ieee":"M. Hledik, T. R. Sokolowski, and G. Tkačik, “A tight upper bound on mutual information,” in <i>IEEE Information Theory Workshop, ITW 2019</i>, Visby, Sweden, 2019.","short":"M. Hledik, T.R. Sokolowski, G. Tkačik, in:, IEEE Information Theory Workshop, ITW 2019, IEEE, 2019.","ista":"Hledik M, Sokolowski TR, Tkačik G. 2019. A tight upper bound on mutual information. IEEE Information Theory Workshop, ITW 2019. Information Theory Workshop, 8989292.","mla":"Hledik, Michal, et al. “A Tight Upper Bound on Mutual Information.” <i>IEEE Information Theory Workshop, ITW 2019</i>, 8989292, IEEE, 2019, doi:<a href=\"https://doi.org/10.1109/ITW44776.2019.8989292\">10.1109/ITW44776.2019.8989292</a>."},"title":"A tight upper bound on mutual information","type":"conference","year":"2019","publication_identifier":{"isbn":["9781538669006"]},"day":"01","date_updated":"2026-04-07T12:59:24Z","department":[{"_id":"GaTk"}],"date_published":"2019-08-01T00:00:00Z","language":[{"iso":"eng"}],"isi":1,"status":"public","oa":1,"month":"08","publication":"IEEE Information Theory Workshop, ITW 2019","quality_controlled":"1","date_created":"2020-03-22T23:00:47Z","scopus_import":"1","_id":"7606","abstract":[{"text":"We derive a tight lower bound on equivocation (conditional entropy), or equivalently a tight upper bound on mutual information between a signal variable and channel outputs. The bound is in terms of the joint distribution of the signals and maximum a posteriori decodes (most probable signals given channel output). As part of our derivation, we describe the key properties of the distribution of signals, channel outputs and decodes, that minimizes equivocation and maximizes mutual information. This work addresses a problem in data analysis, where mutual information between signals and decodes is sometimes used to lower bound the mutual information between signals and channel outputs. Our result provides a corresponding upper bound.","lang":"eng"}],"ec_funded":1,"publisher":"IEEE"},{"extern":"1","publisher":"ChemRxiv","abstract":[{"text":"Electrodepositing  insulating  and  insoluble  Li2O2  is  the  key  process  during  discharge  of  aprotic  Li-O2 batteries  and  determines  rate,  capacity,  and  reversibility.  Current  understanding  states  that  the partition  between  surface  adsorbed  and  solvated  LiO2  governs  whether  Li2O2  grows  as  surface  film, leading to low capacity even at low rates, or in solution, leading to particles and high capacities. Here we show that Li2O2 forms to the widest extent as particles via solution mediated LiO2 disproportionation. We  describe  a  unified  Li2O2  growth  model  that  conclusively  explains  capacity  limitations  across  the whole range of electrolytes. Deciding for particle morphology, achievable rate and capacities are species mobilities,   electrode   specific   surface   area   (determining  true   areal   rate)   and   the  concentration distribution of associated LiO2 in solution. Provided that species mobilities and surface are high, high, capacities are possible even with low-donor-number electrolytes, previously considered prototypical for low   capacity   via   surface   growth.   The   tools   for   these   insights   are   microscopy,   hydrodynamic voltammetry, a numerical reaction model, and in situ small/wide angle X-ray scattering (SAXS/WAXS). Combined with sophisticated data analysis, SAXS allows retrieving rich quantitative information from complex multi-phase systems. On a wider perspective, this SAXS method is a powerful in situ metrology with  atomic  to  sub-micron  resolution  to  study  mechanisms  in  complex  electrochemical  systems  and beyond. ","lang":"eng"}],"_id":"7627","date_created":"2020-04-01T10:10:21Z","page":"50","month":"12","status":"public","oa":1,"publication_status":"submitted","oa_version":"Preprint","date_published":"2019-12-26T00:00:00Z","language":[{"iso":"eng"}],"date_updated":"2020-04-06T10:36:21Z","day":"26","author":[{"full_name":"Prehal, Christian","last_name":"Prehal","first_name":"Christian"},{"last_name":"Samojlov","full_name":"Samojlov, Aleksej","first_name":"Aleksej"},{"full_name":"Nachtnebel, Manfred","last_name":"Nachtnebel","first_name":"Manfred"},{"first_name":"Manfred","full_name":"Kriechbaum, Manfred","last_name":"Kriechbaum"},{"first_name":"Heinz","last_name":"Amenitsch","full_name":"Amenitsch, Heinz"},{"first_name":"Stefan Alexander","id":"A8CA28E6-CE23-11E9-AD2D-EC27E6697425","last_name":"Freunberger","orcid":"0000-0003-2902-5319","full_name":"Freunberger, Stefan Alexander"}],"type":"preprint","year":"2019","title":"A revised O2 reduction model in Li-O2 batteries as revealed by in situ small angle X-ray scattering","citation":{"short":"C. Prehal, A. Samojlov, M. Nachtnebel, M. Kriechbaum, H. Amenitsch, S.A. Freunberger, (n.d.).","ista":"Prehal C, Samojlov A, Nachtnebel M, Kriechbaum M, Amenitsch H, Freunberger SA. A revised O2 reduction model in Li-O2 batteries as revealed by in situ small angle X-ray scattering.","mla":"Prehal, Christian, et al. <i>A Revised O2 Reduction Model in Li-O2 Batteries as Revealed by in Situ Small Angle X-Ray Scattering</i>. ChemRxiv.","ama":"Prehal C, Samojlov A, Nachtnebel M, Kriechbaum M, Amenitsch H, Freunberger SA. A revised O2 reduction model in Li-O2 batteries as revealed by in situ small angle X-ray scattering.","chicago":"Prehal, Christian, Aleksej Samojlov, Manfred Nachtnebel, Manfred Kriechbaum, Heinz Amenitsch, and Stefan Alexander Freunberger. “A Revised O2 Reduction Model in Li-O2 Batteries as Revealed by in Situ Small Angle X-Ray Scattering.” ChemRxiv, n.d.","apa":"Prehal, C., Samojlov, A., Nachtnebel, M., Kriechbaum, M., Amenitsch, H., &#38; Freunberger, S. A. (n.d.). A revised O2 reduction model in Li-O2 batteries as revealed by in situ small angle X-ray scattering. ChemRxiv.","ieee":"C. Prehal, A. Samojlov, M. Nachtnebel, M. Kriechbaum, H. Amenitsch, and S. A. Freunberger, “A revised O2 reduction model in Li-O2 batteries as revealed by in situ small angle X-ray scattering.” ChemRxiv."},"article_processing_charge":"No","main_file_link":[{"url":"https://doi.org/10.26434/chemrxiv.11447775.v1","open_access":"1"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"},{"oa_version":"None","language":[{"iso":"eng"}],"date_published":"2019-10-01T00:00:00Z","department":[{"_id":"VlKo"}],"author":[{"first_name":"Amal","full_name":"Rannen-Triki, Amal","last_name":"Rannen-Triki"},{"last_name":"Berman","full_name":"Berman, Maxim","first_name":"Maxim"},{"first_name":"Vladimir","id":"3D50B0BA-F248-11E8-B48F-1D18A9856A87","last_name":"Kolmogorov","full_name":"Kolmogorov, Vladimir"},{"first_name":"Matthew B.","last_name":"Blaschko","full_name":"Blaschko, Matthew B."}],"day":"01","date_updated":"2023-09-08T11:19:12Z","doi":"10.1109/ICCVW.2019.00097","year":"2019","publication_identifier":{"isbn":["9781728150239"]},"type":"conference","title":"Function norms for neural networks","citation":{"short":"A. Rannen-Triki, M. Berman, V. Kolmogorov, M.B. Blaschko, in:, Proceedings of the 2019 International Conference on Computer Vision Workshop, IEEE, 2019.","mla":"Rannen-Triki, Amal, et al. “Function Norms for Neural Networks.” <i>Proceedings of the 2019 International Conference on Computer Vision Workshop</i>, 748–752, IEEE, 2019, doi:<a href=\"https://doi.org/10.1109/ICCVW.2019.00097\">10.1109/ICCVW.2019.00097</a>.","ista":"Rannen-Triki A, Berman M, Kolmogorov V, Blaschko MB. 2019. Function norms for neural networks. Proceedings of the 2019 International Conference on Computer Vision Workshop. ICCVW: International Conference on Computer Vision Workshop, 748–752.","ieee":"A. Rannen-Triki, M. Berman, V. Kolmogorov, and M. B. Blaschko, “Function norms for neural networks,” in <i>Proceedings of the 2019 International Conference on Computer Vision Workshop</i>, Seoul, South Korea, 2019.","chicago":"Rannen-Triki, Amal, Maxim Berman, Vladimir Kolmogorov, and Matthew B. Blaschko. “Function Norms for Neural Networks.” In <i>Proceedings of the 2019 International Conference on Computer Vision Workshop</i>. IEEE, 2019. <a href=\"https://doi.org/10.1109/ICCVW.2019.00097\">https://doi.org/10.1109/ICCVW.2019.00097</a>.","apa":"Rannen-Triki, A., Berman, M., Kolmogorov, V., &#38; Blaschko, M. B. (2019). Function norms for neural networks. In <i>Proceedings of the 2019 International Conference on Computer Vision Workshop</i>. Seoul, South Korea: IEEE. <a href=\"https://doi.org/10.1109/ICCVW.2019.00097\">https://doi.org/10.1109/ICCVW.2019.00097</a>","ama":"Rannen-Triki A, Berman M, Kolmogorov V, Blaschko MB. Function norms for neural networks. In: <i>Proceedings of the 2019 International Conference on Computer Vision Workshop</i>. IEEE; 2019. doi:<a href=\"https://doi.org/10.1109/ICCVW.2019.00097\">10.1109/ICCVW.2019.00097</a>"},"article_processing_charge":"No","conference":{"start_date":"2019-10-27","location":"Seoul, South Korea","name":"ICCVW: International Conference on Computer Vision Workshop","end_date":"2019-10-28"},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","external_id":{"isi":["000554591600090"]},"publisher":"IEEE","abstract":[{"text":"Deep neural networks (DNNs) have become increasingly important due to their excellent empirical performance on a wide range of problems. However, regularization is generally achieved by indirect means, largely due to the complex set of functions defined by a network and the difficulty in measuring function complexity. There exists no method in the literature for additive regularization based on a norm of the function, as is classically considered in statistical learning theory. In this work, we study the tractability of function norms for deep neural networks with ReLU activations. We provide, to the best of our knowledge, the first proof in the literature of the NP-hardness of computing function norms of DNNs of 3 or more layers. We also highlight a fundamental difference between shallow and deep networks. In the light on these results, we propose a new regularization strategy based on approximate function norms, and show its efficiency on a segmentation task with a DNN.","lang":"eng"}],"_id":"7639","date_created":"2020-04-05T22:00:50Z","scopus_import":"1","quality_controlled":"1","month":"10","publication":"Proceedings of the 2019 International Conference on Computer Vision Workshop","status":"public","article_number":"748-752","publication_status":"published","isi":1},{"arxiv":1,"article_number":"1749-1753","publication_status":"published","doi":"10.1109/ICCVW.2019.00217","author":[{"first_name":"Alexander","id":"2D157DB6-F248-11E8-B48F-1D18A9856A87","last_name":"Kolesnikov","full_name":"Kolesnikov, Alexander"},{"last_name":"Kuznetsova","full_name":"Kuznetsova, Alina","first_name":"Alina"},{"id":"40C20FD2-F248-11E8-B48F-1D18A9856A87","first_name":"Christoph","full_name":"Lampert, Christoph","last_name":"Lampert","orcid":"0000-0001-8622-7887"},{"first_name":"Vittorio","full_name":"Ferrari, Vittorio","last_name":"Ferrari"}],"oa_version":"Preprint","external_id":{"isi":["000554591601098"],"arxiv":["1807.02136"]},"_id":"7640","scopus_import":"1","date_created":"2020-04-05T22:00:51Z","ec_funded":1,"abstract":[{"text":"We propose a new model for detecting visual relationships, such as \"person riding motorcycle\" or \"bottle on table\". This task is an important step towards comprehensive structured mage understanding, going beyond detecting individual objects. Our main novelty is a Box Attention mechanism that allows to model pairwise interactions between objects using standard object detection pipelines. The resulting model is conceptually clean, expressive and relies on well-justified training and prediction procedures. Moreover, unlike previously proposed approaches, our model does not introduce any additional complex components or hyperparameters on top of those already required by the underlying detection model. We conduct an experimental evaluation on two datasets, V-COCO and Open Images, demonstrating strong quantitative and qualitative results.","lang":"eng"}],"publisher":"IEEE","isi":1,"publication":"Proceedings of the 2019 International Conference on Computer Vision Workshop","month":"10","status":"public","oa":1,"quality_controlled":"1","type":"conference","publication_identifier":{"isbn":["9781728150239"]},"year":"2019","day":"01","date_updated":"2025-04-15T07:10:23Z","department":[{"_id":"ChLa"}],"date_published":"2019-10-01T00:00:00Z","language":[{"iso":"eng"}],"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","article_processing_charge":"No","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1807.02136"}],"conference":{"end_date":"2019-10-28","name":"ICCVW: International Conference on Computer Vision Workshop","location":"Seoul, South Korea","start_date":"2019-10-27"},"project":[{"call_identifier":"FP7","_id":"2532554C-B435-11E9-9278-68D0E5697425","name":"Lifelong Learning of Visual Scene Understanding","grant_number":"308036"}],"title":"Detecting visual relationships using box attention","citation":{"ista":"Kolesnikov A, Kuznetsova A, Lampert C, Ferrari V. 2019. Detecting visual relationships using box attention. Proceedings of the 2019 International Conference on Computer Vision Workshop. ICCVW: International Conference on Computer Vision Workshop, 1749–1753.","mla":"Kolesnikov, Alexander, et al. “Detecting Visual Relationships Using Box Attention.” <i>Proceedings of the 2019 International Conference on Computer Vision Workshop</i>, 1749–1753, IEEE, 2019, doi:<a href=\"https://doi.org/10.1109/ICCVW.2019.00217\">10.1109/ICCVW.2019.00217</a>.","short":"A. Kolesnikov, A. Kuznetsova, C. Lampert, V. Ferrari, in:, Proceedings of the 2019 International Conference on Computer Vision Workshop, IEEE, 2019.","apa":"Kolesnikov, A., Kuznetsova, A., Lampert, C., &#38; Ferrari, V. (2019). Detecting visual relationships using box attention. In <i>Proceedings of the 2019 International Conference on Computer Vision Workshop</i>. Seoul, South Korea: IEEE. <a href=\"https://doi.org/10.1109/ICCVW.2019.00217\">https://doi.org/10.1109/ICCVW.2019.00217</a>","chicago":"Kolesnikov, Alexander, Alina Kuznetsova, Christoph Lampert, and Vittorio Ferrari. “Detecting Visual Relationships Using Box Attention.” In <i>Proceedings of the 2019 International Conference on Computer Vision Workshop</i>. IEEE, 2019. <a href=\"https://doi.org/10.1109/ICCVW.2019.00217\">https://doi.org/10.1109/ICCVW.2019.00217</a>.","ama":"Kolesnikov A, Kuznetsova A, Lampert C, Ferrari V. Detecting visual relationships using box attention. In: <i>Proceedings of the 2019 International Conference on Computer Vision Workshop</i>. IEEE; 2019. doi:<a href=\"https://doi.org/10.1109/ICCVW.2019.00217\">10.1109/ICCVW.2019.00217</a>","ieee":"A. Kolesnikov, A. Kuznetsova, C. Lampert, and V. Ferrari, “Detecting visual relationships using box attention,” in <i>Proceedings of the 2019 International Conference on Computer Vision Workshop</i>, Seoul, South Korea, 2019."}},{"doi":"10.1038/s41467-019-13225-y","publication_identifier":{"issn":["2041-1723"]},"type":"journal_article","year":"2019","author":[{"last_name":"Delaneau","full_name":"Delaneau, Olivier","first_name":"Olivier"},{"first_name":"Jean-François","last_name":"Zagury","full_name":"Zagury, Jean-François"},{"id":"E5D42276-F5DA-11E9-8E24-6303E6697425","first_name":"Matthew Richard","full_name":"Robinson, Matthew Richard","orcid":"0000-0001-8982-8813","last_name":"Robinson"},{"full_name":"Marchini, Jonathan L.","last_name":"Marchini","first_name":"Jonathan L."},{"first_name":"Emmanouil T.","full_name":"Dermitzakis, Emmanouil T.","last_name":"Dermitzakis"}],"date_updated":"2021-01-12T08:15:01Z","day":"28","oa_version":"Published Version","date_published":"2019-11-28T00:00:00Z","language":[{"iso":"eng"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_processing_charge":"No","main_file_link":[{"url":"https://doi.org/10.1038/s41467-019-13225-y","open_access":"1"}],"volume":10,"title":"Accurate, scalable and integrative haplotype estimation","citation":{"mla":"Delaneau, Olivier, et al. “Accurate, Scalable and Integrative Haplotype Estimation.” <i>Nature Communications</i>, vol. 10, 5436, Springer Nature, 2019, doi:<a href=\"https://doi.org/10.1038/s41467-019-13225-y\">10.1038/s41467-019-13225-y</a>.","ista":"Delaneau O, Zagury J-F, Robinson MR, Marchini JL, Dermitzakis ET. 2019. Accurate, scalable and integrative haplotype estimation. Nature Communications. 10, 5436.","short":"O. Delaneau, J.-F. Zagury, M.R. Robinson, J.L. Marchini, E.T. Dermitzakis, Nature Communications 10 (2019).","ama":"Delaneau O, Zagury J-F, Robinson MR, Marchini JL, Dermitzakis ET. Accurate, scalable and integrative haplotype estimation. <i>Nature Communications</i>. 2019;10. doi:<a href=\"https://doi.org/10.1038/s41467-019-13225-y\">10.1038/s41467-019-13225-y</a>","chicago":"Delaneau, Olivier, Jean-François Zagury, Matthew Richard Robinson, Jonathan L. Marchini, and Emmanouil T. Dermitzakis. “Accurate, Scalable and Integrative Haplotype Estimation.” <i>Nature Communications</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1038/s41467-019-13225-y\">https://doi.org/10.1038/s41467-019-13225-y</a>.","ieee":"O. Delaneau, J.-F. Zagury, M. R. Robinson, J. L. Marchini, and E. T. Dermitzakis, “Accurate, scalable and integrative haplotype estimation,” <i>Nature Communications</i>, vol. 10. Springer Nature, 2019.","apa":"Delaneau, O., Zagury, J.-F., Robinson, M. R., Marchini, J. L., &#38; Dermitzakis, E. T. (2019). Accurate, scalable and integrative haplotype estimation. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-019-13225-y\">https://doi.org/10.1038/s41467-019-13225-y</a>"},"_id":"7710","date_created":"2020-04-30T10:40:32Z","abstract":[{"lang":"eng","text":"The number of human genomes being genotyped or sequenced increases exponentially and efficient haplotype estimation methods able to handle this amount of data are now required. Here we present a method, SHAPEIT4, which substantially improves upon other methods to process large genotype and high coverage sequencing datasets. It notably exhibits sub-linear running times with sample size, provides highly accurate haplotypes and allows integrating external phasing information such as large reference panels of haplotypes, collections of pre-phased variants and long sequencing reads. We provide SHAPEIT4 in an open source format and demonstrate its performance in terms of accuracy and running times on two gold standard datasets: the UK Biobank data and the Genome In A Bottle."}],"article_type":"original","extern":"1","publisher":"Springer Nature","publication_status":"published","article_number":"5436","publication":"Nature Communications","month":"11","status":"public","oa":1,"intvolume":"        10","quality_controlled":"1"},{"oa_version":"None","date_published":"2019-12-09T00:00:00Z","language":[{"iso":"eng"}],"author":[{"first_name":"Roel P. J.","full_name":"Bevers, Roel P. J.","last_name":"Bevers"},{"full_name":"Litovchenko, Maria","last_name":"Litovchenko","first_name":"Maria"},{"first_name":"Adamandia","last_name":"Kapopoulou","full_name":"Kapopoulou, Adamandia"},{"full_name":"Braman, Virginie S.","last_name":"Braman","first_name":"Virginie S."},{"id":"E5D42276-F5DA-11E9-8E24-6303E6697425","first_name":"Matthew Richard","full_name":"Robinson, Matthew Richard","orcid":"0000-0001-8982-8813","last_name":"Robinson"},{"last_name":"Auwerx","full_name":"Auwerx, Johan","first_name":"Johan"},{"first_name":"Brian","full_name":"Hollis, Brian","last_name":"Hollis"},{"first_name":"Bart","full_name":"Deplancke, Bart","last_name":"Deplancke"}],"date_updated":"2021-01-12T08:15:01Z","day":"09","doi":"10.1038/s42255-019-0147-3","publication_identifier":{"issn":["2522-5812"]},"year":"2019","type":"journal_article","title":"Mitochondrial haplotypes affect metabolic phenotypes in the Drosophila Genetic Reference Panel","related_material":{"link":[{"relation":"erratum","url":"https://doi.org/10.1038/s42255-020-0202-0"}]},"citation":{"apa":"Bevers, R. P. J., Litovchenko, M., Kapopoulou, A., Braman, V. S., Robinson, M. R., Auwerx, J., … Deplancke, B. (2019). Mitochondrial haplotypes affect metabolic phenotypes in the Drosophila Genetic Reference Panel. <i>Nature Metabolism</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s42255-019-0147-3\">https://doi.org/10.1038/s42255-019-0147-3</a>","ieee":"R. P. J. Bevers <i>et al.</i>, “Mitochondrial haplotypes affect metabolic phenotypes in the Drosophila Genetic Reference Panel,” <i>Nature Metabolism</i>, vol. 1, no. 12. Springer Nature, pp. 1226–1242, 2019.","ama":"Bevers RPJ, Litovchenko M, Kapopoulou A, et al. Mitochondrial haplotypes affect metabolic phenotypes in the Drosophila Genetic Reference Panel. <i>Nature Metabolism</i>. 2019;1(12):1226-1242. doi:<a href=\"https://doi.org/10.1038/s42255-019-0147-3\">10.1038/s42255-019-0147-3</a>","chicago":"Bevers, Roel P. J., Maria Litovchenko, Adamandia Kapopoulou, Virginie S. Braman, Matthew Richard Robinson, Johan Auwerx, Brian Hollis, and Bart Deplancke. “Mitochondrial Haplotypes Affect Metabolic Phenotypes in the Drosophila Genetic Reference Panel.” <i>Nature Metabolism</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1038/s42255-019-0147-3\">https://doi.org/10.1038/s42255-019-0147-3</a>.","short":"R.P.J. Bevers, M. Litovchenko, A. Kapopoulou, V.S. Braman, M.R. Robinson, J. Auwerx, B. Hollis, B. Deplancke, Nature Metabolism 1 (2019) 1226–1242.","ista":"Bevers RPJ, Litovchenko M, Kapopoulou A, Braman VS, Robinson MR, Auwerx J, Hollis B, Deplancke B. 2019. Mitochondrial haplotypes affect metabolic phenotypes in the Drosophila Genetic Reference Panel. Nature Metabolism. 1(12), 1226–1242.","mla":"Bevers, Roel P. J., et al. “Mitochondrial Haplotypes Affect Metabolic Phenotypes in the Drosophila Genetic Reference Panel.” <i>Nature Metabolism</i>, vol. 1, no. 12, Springer Nature, 2019, pp. 1226–42, doi:<a href=\"https://doi.org/10.1038/s42255-019-0147-3\">10.1038/s42255-019-0147-3</a>."},"volume":1,"article_processing_charge":"No","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"Springer Nature","extern":"1","abstract":[{"text":"The nature and extent of mitochondrial DNA variation in a population and how it affects traits is poorly understood. Here we resequence the mitochondrial genomes of 169 Drosophila Genetic Reference Panel lines, identifying 231 variants that stratify along 12 mitochondrial haplotypes. We identify 1,845 cases of mitonuclear allelic imbalances, thus implying that mitochondrial haplotypes are reflected in the nuclear genome. However, no major fitness effects are associated with mitonuclear imbalance, suggesting that such imbalances reflect population structure at the mitochondrial level rather than genomic incompatibilities. Although mitochondrial haplotypes have no direct impact on mitochondrial respiration, some haplotypes are associated with stress- and metabolism-related phenotypes, including food intake in males. Finally, through reciprocal swapping of mitochondrial genomes, we demonstrate that a mitochondrial haplotype associated with high food intake can rescue a low food intake phenotype. Together, our findings provide new insight into population structure at the mitochondrial level and point to the importance of incorporating mitochondrial haplotypes in genotype–phenotype relationship studies.","lang":"eng"}],"article_type":"original","_id":"7711","page":"1226-1242","date_created":"2020-04-30T10:40:56Z","intvolume":"         1","quality_controlled":"1","month":"12","publication":"Nature Metabolism","status":"public","issue":"12","publication_status":"published"},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_processing_charge":"No","main_file_link":[{"url":"https://doi.org/10.1101/632380 ","open_access":"1"}],"title":"Maximum likelihood method quantifies the overall contribution of gene-environment interaction to continuous traits: An application to complex traits in the UK Biobank","citation":{"apa":"Sulc, J., Mounier, N., Günther, F., Winkler, T., Wood, A. R., Frayling, T. M., … Kutalik, Z. (2019). Maximum likelihood method quantifies the overall contribution of gene-environment interaction to continuous traits: An application to complex traits in the UK Biobank. <i>bioRxiv</i>. Cold Spring Harbor Laboratory.","ama":"Sulc J, Mounier N, Günther F, et al. Maximum likelihood method quantifies the overall contribution of gene-environment interaction to continuous traits: An application to complex traits in the UK Biobank. <i>bioRxiv</i>. 2019.","ieee":"J. Sulc <i>et al.</i>, “Maximum likelihood method quantifies the overall contribution of gene-environment interaction to continuous traits: An application to complex traits in the UK Biobank,” <i>bioRxiv</i>. Cold Spring Harbor Laboratory, 2019.","chicago":"Sulc, Jonathan, Ninon Mounier, Felix Günther, Thomas Winkler, Andrew R. Wood, Timothy M. Frayling, Iris M. Heid, Matthew Richard Robinson, and Zoltán Kutalik. “Maximum Likelihood Method Quantifies the Overall Contribution of Gene-Environment Interaction to Continuous Traits: An Application to Complex Traits in the UK Biobank.” <i>BioRxiv</i>. Cold Spring Harbor Laboratory, 2019.","ista":"Sulc J, Mounier N, Günther F, Winkler T, Wood AR, Frayling TM, Heid IM, Robinson MR, Kutalik Z. 2019. Maximum likelihood method quantifies the overall contribution of gene-environment interaction to continuous traits: An application to complex traits in the UK Biobank. bioRxiv, .","mla":"Sulc, Jonathan, et al. “Maximum Likelihood Method Quantifies the Overall Contribution of Gene-Environment Interaction to Continuous Traits: An Application to Complex Traits in the UK Biobank.” <i>BioRxiv</i>, Cold Spring Harbor Laboratory, 2019.","short":"J. Sulc, N. Mounier, F. Günther, T. Winkler, A.R. Wood, T.M. Frayling, I.M. Heid, M.R. Robinson, Z. Kutalik, BioRxiv (2019)."},"year":"2019","type":"preprint","author":[{"last_name":"Sulc","full_name":"Sulc, Jonathan","first_name":"Jonathan"},{"first_name":"Ninon","last_name":"Mounier","full_name":"Mounier, Ninon"},{"first_name":"Felix","last_name":"Günther","full_name":"Günther, Felix"},{"first_name":"Thomas","last_name":"Winkler","full_name":"Winkler, Thomas"},{"last_name":"Wood","full_name":"Wood, Andrew R.","first_name":"Andrew R."},{"full_name":"Frayling, Timothy M.","last_name":"Frayling","first_name":"Timothy M."},{"first_name":"Iris M.","last_name":"Heid","full_name":"Heid, Iris M."},{"first_name":"Matthew Richard","id":"E5D42276-F5DA-11E9-8E24-6303E6697425","last_name":"Robinson","orcid":"0000-0001-8982-8813","full_name":"Robinson, Matthew Richard"},{"first_name":"Zoltán","full_name":"Kutalik, Zoltán","last_name":"Kutalik"}],"date_updated":"2021-01-12T08:15:30Z","day":"14","oa_version":"Preprint","language":[{"iso":"eng"}],"date_published":"2019-06-14T00:00:00Z","publication_status":"published","publication":"bioRxiv","month":"06","oa":1,"status":"public","_id":"7782","date_created":"2020-04-30T13:04:26Z","page":"20","abstract":[{"text":"As genome-wide association studies (GWAS) increased in size, numerous gene-environment interactions (GxE) have been discovered, many of which however explore only one environment at a time and may suffer from statistical artefacts leading to biased interaction estimates. Here we propose a maximum likelihood method to estimate the contribution of GxE to complex traits taking into account all interacting environmental variables at the same time, without the need to measure any. This is possible because GxE induces fluctuations in the conditional trait variance, the extent of which depends on the strength of GxE. The approach can be applied to continuous outcomes and for single SNPs or genetic risk scores (GRS). Extensive simulations demonstrated that our method yields unbiased interaction estimates and excellent confidence interval coverage. We also offer a strategy to distinguish specific GxE from general heteroscedasticity (scale effects). Applying our method to 32 complex traits in the UK Biobank reveals that for body mass index (BMI) the GRSxE explains an additional 1.9% variance on top of the 5.2% GRS contribution. However, this interaction is not specific to the GRS and holds for any variable similarly correlated with BMI. On the contrary, the GRSxE interaction effect for leg impedance Embedded Image is significantly (P < 10−56) larger than it would be expected for a similarly correlated variable Embedded Image. We showed that our method could robustly detect the global contribution of GxE to complex traits, which turned out to be substantial for certain obesity measures.","lang":"eng"}],"extern":"1","publisher":"Cold Spring Harbor Laboratory"},{"date_created":"2020-06-08T12:25:25Z","_id":"7950","abstract":[{"lang":"eng","text":"The input to the token swapping problem is a graph with vertices v1, v2, . . . , vn, and n tokens with labels 1,2, . . . , n, one on each vertex.  The goal is to get token i to vertex vi for all i= 1, . . . , n using a minimum number of swaps, where a swap exchanges the tokens on the endpoints of an edge.Token swapping on a tree, also known as “sorting with a transposition tree,” is not known to be in P nor NP-complete.  We present some partial results:\r\n1.  An optimum swap sequence may need to perform a swap on a leaf vertex that has the correct token (a “happy leaf”), disproving a conjecture of Vaughan.\r\n2.  Any algorithm that fixes happy leaves—as all known approximation algorithms for the problem do—has approximation factor at least 4/3.  Furthermore, the two best-known 2-approximation algorithms have approximation factor exactly 2.\r\n3.  A generalized problem—weighted coloured token swapping—is NP-complete on trees, but solvable in polynomial time on paths and stars.  In this version, tokens and  vertices  have  colours,  and  colours  have  weights.   The  goal  is  to  get  every token to a vertex of the same colour, and the cost of a swap is the sum of the weights of the two tokens involved."}],"arxiv":1,"status":"public","oa":1,"month":"03","publication":"arXiv","article_number":"1903.06981","publication_status":"draft","day":"16","date_updated":"2026-04-08T07:23:00Z","author":[{"last_name":"Biniaz","full_name":"Biniaz, Ahmad","first_name":"Ahmad"},{"first_name":"Kshitij","last_name":"Jain","full_name":"Jain, Kshitij"},{"last_name":"Lubiw","full_name":"Lubiw, Anna","first_name":"Anna"},{"first_name":"Zuzana","id":"45CFE238-F248-11E8-B48F-1D18A9856A87","last_name":"Masárová","orcid":"0000-0002-6660-1322","full_name":"Masárová, Zuzana"},{"first_name":"Tillmann","last_name":"Miltzow","full_name":"Miltzow, Tillmann"},{"first_name":"Debajyoti","full_name":"Mondal, Debajyoti","last_name":"Mondal"},{"first_name":"Anurag Murty","last_name":"Naredla","full_name":"Naredla, Anurag Murty"},{"orcid":"0000-0002-1097-9684","last_name":"Tkadlec","full_name":"Tkadlec, Josef","first_name":"Josef","id":"3F24CCC8-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Alexi","last_name":"Turcotte","full_name":"Turcotte, Alexi"}],"year":"2019","type":"preprint","doi":"10.48550/arXiv.1903.06981","language":[{"iso":"eng"}],"date_published":"2019-03-16T00:00:00Z","oa_version":"Preprint","department":[{"_id":"HeEd"},{"_id":"UlWa"},{"_id":"KrCh"}],"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1903.06981"}],"article_processing_charge":"No","external_id":{"arxiv":["1903.06981"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"mla":"Biniaz, Ahmad, et al. “Token Swapping on Trees.” <i>ArXiv</i>, 1903.06981, doi:<a href=\"https://doi.org/10.48550/arXiv.1903.06981\">10.48550/arXiv.1903.06981</a>.","ista":"Biniaz A, Jain K, Lubiw A, Masárová Z, Miltzow T, Mondal D, Naredla AM, Tkadlec J, Turcotte A. Token swapping on trees. arXiv, 1903.06981.","short":"A. Biniaz, K. Jain, A. Lubiw, Z. Masárová, T. Miltzow, D. Mondal, A.M. Naredla, J. Tkadlec, A. Turcotte, ArXiv (n.d.).","chicago":"Biniaz, Ahmad, Kshitij Jain, Anna Lubiw, Zuzana Masárová, Tillmann Miltzow, Debajyoti Mondal, Anurag Murty Naredla, Josef Tkadlec, and Alexi Turcotte. “Token Swapping on Trees.” <i>ArXiv</i>, n.d. <a href=\"https://doi.org/10.48550/arXiv.1903.06981\">https://doi.org/10.48550/arXiv.1903.06981</a>.","apa":"Biniaz, A., Jain, K., Lubiw, A., Masárová, Z., Miltzow, T., Mondal, D., … Turcotte, A. (n.d.). Token swapping on trees. <i>arXiv</i>. <a href=\"https://doi.org/10.48550/arXiv.1903.06981\">https://doi.org/10.48550/arXiv.1903.06981</a>","ama":"Biniaz A, Jain K, Lubiw A, et al. Token swapping on trees. <i>arXiv</i>. doi:<a href=\"https://doi.org/10.48550/arXiv.1903.06981\">10.48550/arXiv.1903.06981</a>","ieee":"A. Biniaz <i>et al.</i>, “Token swapping on trees,” <i>arXiv</i>. ."},"related_material":{"record":[{"id":"12833","status":"public","relation":"later_version"},{"relation":"dissertation_contains","status":"public","id":"7944"}]},"title":"Token swapping on trees"},{"doi":"10.1523/JNEUROSCI.1059-18.2018","author":[{"last_name":"Trébuchet","full_name":"Trébuchet, Guillaume","first_name":"Guillaume"},{"full_name":"Cattenoz, Pierre B","last_name":"Cattenoz","first_name":"Pierre B"},{"first_name":"János","last_name":"Zsámboki","full_name":"Zsámboki, János"},{"first_name":"David","full_name":"Mazaud, David","last_name":"Mazaud"},{"first_name":"Daria E","id":"3D224B9E-F248-11E8-B48F-1D18A9856A87","last_name":"Siekhaus","orcid":"0000-0001-8323-8353","full_name":"Siekhaus, Daria E"},{"first_name":"Manolis","full_name":"Fanto, Manolis","last_name":"Fanto"},{"first_name":"Angela","last_name":"Giangrande","full_name":"Giangrande, Angela"}],"file":[{"relation":"main_file","access_level":"open_access","file_id":"8596","file_size":9455414,"content_type":"application/pdf","checksum":"8f6925eb4cd1e8747d8ea25929c68de6","creator":"dernst","file_name":"2019_JournNeuroscience_Trebuchet.pdf","date_created":"2020-10-02T09:33:28Z","date_updated":"2020-10-02T09:33:28Z","success":1}],"oa_version":"Published Version","external_id":{"isi":["000455189900006"],"pmid":["30504274"]},"pmid":1,"publication_status":"published","issue":"2","intvolume":"        39","type":"journal_article","year":"2019","day":"09","date_updated":"2025-04-15T06:52:10Z","file_date_updated":"2020-10-02T09:33:28Z","department":[{"_id":"DaSi"}],"has_accepted_license":"1","language":[{"iso":"eng"}],"date_published":"2019-01-09T00:00:00Z","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","article_processing_charge":"No","volume":39,"project":[{"grant_number":"334077","name":"Investigating the role of transporters in invasive migration through junctions","_id":"2536F660-B435-11E9-9278-68D0E5697425","call_identifier":"FP7"}],"citation":{"mla":"Trébuchet, Guillaume, et al. “The Repo Homeodomain Transcription Factor Suppresses Hematopoiesis in Drosophila and Preserves the Glial Fate.” <i>Journal of Neuroscience</i>, vol. 39, no. 2, Society for Neuroscience, 2019, pp. 238–55, doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.1059-18.2018\">10.1523/JNEUROSCI.1059-18.2018</a>.","ista":"Trébuchet G, Cattenoz PB, Zsámboki J, Mazaud D, Siekhaus DE, Fanto M, Giangrande A. 2019. The Repo homeodomain transcription factor suppresses hematopoiesis in Drosophila and preserves the glial fate. Journal of Neuroscience. 39(2), 238–255.","short":"G. Trébuchet, P.B. Cattenoz, J. Zsámboki, D. Mazaud, D.E. Siekhaus, M. Fanto, A. Giangrande, Journal of Neuroscience 39 (2019) 238–255.","chicago":"Trébuchet, Guillaume, Pierre B Cattenoz, János Zsámboki, David Mazaud, Daria E Siekhaus, Manolis Fanto, and Angela Giangrande. “The Repo Homeodomain Transcription Factor Suppresses Hematopoiesis in Drosophila and Preserves the Glial Fate.” <i>Journal of Neuroscience</i>. Society for Neuroscience, 2019. <a href=\"https://doi.org/10.1523/JNEUROSCI.1059-18.2018\">https://doi.org/10.1523/JNEUROSCI.1059-18.2018</a>.","ama":"Trébuchet G, Cattenoz PB, Zsámboki J, et al. The Repo homeodomain transcription factor suppresses hematopoiesis in Drosophila and preserves the glial fate. <i>Journal of Neuroscience</i>. 2019;39(2):238-255. doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.1059-18.2018\">10.1523/JNEUROSCI.1059-18.2018</a>","ieee":"G. Trébuchet <i>et al.</i>, “The Repo homeodomain transcription factor suppresses hematopoiesis in Drosophila and preserves the glial fate,” <i>Journal of Neuroscience</i>, vol. 39, no. 2. Society for Neuroscience, pp. 238–255, 2019.","apa":"Trébuchet, G., Cattenoz, P. B., Zsámboki, J., Mazaud, D., Siekhaus, D. E., Fanto, M., &#38; Giangrande, A. (2019). The Repo homeodomain transcription factor suppresses hematopoiesis in Drosophila and preserves the glial fate. <i>Journal of Neuroscience</i>. Society for Neuroscience. <a href=\"https://doi.org/10.1523/JNEUROSCI.1059-18.2018\">https://doi.org/10.1523/JNEUROSCI.1059-18.2018</a>"},"title":"The Repo homeodomain transcription factor suppresses hematopoiesis in Drosophila and preserves the glial fate","date_created":"2018-12-11T11:44:07Z","scopus_import":"1","page":"238-255","publist_id":"8048","_id":"8","article_type":"original","acknowledgement":"This work was supported by INSERM, CNRS, UDS, Ligue Régionale contre le Cancer, Hôpital de Strasbourg, Association pour la Recherche sur le Cancer (ARC) and Agence Nationale de la Recherche (ANR) grants. P.B.C. was funded by the ANR and by the ARSEP (Fondation pour l'Aide à la Recherche sur la Sclérose en Plaques), and G.T. by governmental and ARC fellowships. This work was also supported by grants from the Ataxia UK (2491) and the NC3R (NC/L000199/1) awarded to M.F. The Institut de Génétique et de Biologie Moléculaire et Cellulaire was also supported by a French state fund through the ANR labex. D.E.S. was funded by Marie Curie Grant CIG 334077/IRTIM. We thank B. Altenhein, K. Brückner, M. Crozatier, L. Waltzer, M. Logan, E. Kurant, R. Reuter, E. Kurucz, J.L Dimarcq, J. Hoffmann, C. Goodman, the DHSB, and the BDSC for reagents and flies. We also thank all of the laboratory members for comments on the manuscript; C. Diebold, C. Delaporte, M. Pezze, the fly, and imaging and antibody facilities for technical assistance; and D. Dembele for help with statistics. In addition, we thank Alison Brewer for help with Luciferase assays.","abstract":[{"text":"Despite their different origins, Drosophila glia and hemocytes are related cell populations that provide an immune function. Drosophila hemocytes patrol the body cavity and act as macrophages outside the nervous system whereas glia originate from the neuroepithelium and provide the scavenger population of the nervous system. Drosophila glia are hence the functional orthologs of vertebrate microglia, even though the latter are cells of immune origin that subsequently move into the brain during development. Interestingly, the Drosophila immune cells within (glia) and outside the nervous system (hemocytes) require the same transcription factor Glide/Gcm for their development. This raises the issue of how do glia specifically differentiate in the nervous system and hemocytes in the procephalic mesoderm. The Repo homeodomain transcription factor and pan-glial direct target of Glide/Gcm is known to ensure glial terminal differentiation. Here we show that Repo also takes center stage in the process that discriminates between glia and hemocytes. First, Repo expression is repressed in the hemocyte anlagen by mesoderm-specific factors. Second, Repo ectopic activation in the procephalic mesoderm is sufficient to repress the expression of hemocyte-specific genes. Third, the lack of Repo triggers the expression of hemocyte markers in glia. Thus, a complex network of tissue-specific cues biases the potential of Glide/Gcm. These data allow us to revise the concept of fate determinants and help us understand the bases of cell specification. Both sexes were analyzed.SIGNIFICANCE STATEMENTDistinct cell types often require the same pioneer transcription factor, raising the issue of how does one factor trigger different fates. In Drosophila, glia and hemocytes provide a scavenger activity within and outside the nervous system, respectively. While they both require the Glide/Gcm transcription factor, glia originate from the ectoderm, hemocytes from the mesoderm. Here we show that tissue-specific factors inhibit the gliogenic potential of Glide/Gcm in the mesoderm by repressing the expression of the homeodomain protein Repo, a major glial-specific target of Glide/Gcm. Repo expression in turn inhibits the expression of hemocyte-specific genes in the nervous system. These cell-specific networks secure the establishment of the glial fate only in the nervous system and allow cell diversification.","lang":"eng"}],"ec_funded":1,"publisher":"Society for Neuroscience","isi":1,"status":"public","oa":1,"month":"01","publication":"Journal of Neuroscience","quality_controlled":"1","ddc":["570"]}]