[{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"fulldoi":"https://doi.org/10.1111/nph.17349","publication":"New Phytologist","publication_status":"published","date_published":"2021-03-17T00:00:00Z","page":"2275-2291","ddc":["580"],"type":"journal_article","scopus_import":"1","article_type":"original","month":"03","isi":1,"pmid":1,"issue":"6","_id":"9288","year":"2021","department":[{"_id":"JiFr"}],"intvolume":"       230","external_id":{"isi":["000639552400001"],"pmid":["33728703"]},"quality_controlled":"1","doi":"10.1111/nph.17349","author":[{"first_name":"I","last_name":"El Houari","full_name":"El Houari, I"},{"last_name":"Van Beirs","full_name":"Van Beirs, C","first_name":"C"},{"last_name":"Arents","full_name":"Arents, HE","first_name":"HE"},{"first_name":"Huibin","last_name":"Han","id":"31435098-F248-11E8-B48F-1D18A9856A87","full_name":"Han, Huibin"},{"first_name":"A","last_name":"Chanoca","full_name":"Chanoca, A"},{"first_name":"D","last_name":"Opdenacker","full_name":"Opdenacker, D"},{"first_name":"J","last_name":"Pollier","full_name":"Pollier, J"},{"full_name":"Storme, V","last_name":"Storme","first_name":"V"},{"first_name":"W","last_name":"Steenackers","full_name":"Steenackers, W"},{"first_name":"M","full_name":"Quareshy, M","last_name":"Quareshy"},{"last_name":"Napier","full_name":"Napier, R","first_name":"R"},{"full_name":"Beeckman, T","last_name":"Beeckman","first_name":"T"},{"orcid":"0000-0002-8302-7596","id":"4159519E-F248-11E8-B48F-1D18A9856A87","full_name":"Friml, Jiří","last_name":"Friml","first_name":"Jiří"},{"first_name":"B","full_name":"De Rybel, B","last_name":"De Rybel"},{"first_name":"W","full_name":"Boerjan, W","last_name":"Boerjan"},{"first_name":"B","full_name":"Vanholme, B","last_name":"Vanholme"}],"date_updated":"2026-06-18T19:44:45Z","date_created":"2021-03-26T12:09:01Z","main_file_link":[{"open_access":"1","url":"https://biblio.ugent.be/publication/8703799/file/8703800.pdf"}],"status":"public","publisher":"Wiley","abstract":[{"lang":"eng","text":"• The phenylpropanoid pathway serves a central role in plant metabolism, providing numerous compounds involved in diverse physiological processes. Most carbon entering the pathway is incorporated into lignin. Although several phenylpropanoid pathway mutants show seedling growth arrest, the role for lignin in seedling growth and development is unexplored.\r\n• We use complementary pharmacological and genetic approaches to block CINNAMATE‐4‐HYDROXYLASE (C4H) functionality in Arabidopsis seedlings and a set of molecular and biochemical techniques to investigate the underlying phenotypes.\r\n• Blocking C4H resulted in reduced lateral rooting and increased adventitious rooting apically in the hypocotyl. These phenotypes coincided with an inhibition in auxin transport. The upstream accumulation in cis‐cinnamic acid was found to likely cause polar auxin transport inhibition. Conversely, a downstream depletion in lignin perturbed phloem‐mediated auxin transport. Restoring lignin deposition effectively reestablished phloem transport and, accordingly, auxin homeostasis.\r\n• Our results show that the accumulation of bioactive intermediates and depletion in lignin jointly cause the aberrant phenotypes upon blocking C4H, and demonstrate that proper deposition of lignin is essential for the establishment of auxin distribution in seedlings. Our data position the phenylpropanoid pathway and lignin in a new physiological framework, consolidating their importance in plant growth and development."}],"title":"Seedling developmental defects upon blocking CINNAMATE-4-HYDROXYLASE are caused by perturbations in auxin transport","article_processing_charge":"No","volume":230,"citation":{"ista":"El Houari I, Van Beirs C, Arents H, Han H, Chanoca A, Opdenacker D, Pollier J, Storme V, Steenackers W, Quareshy M, Napier R, Beeckman T, Friml J, De Rybel B, Boerjan W, Vanholme B. 2021. Seedling developmental defects upon blocking CINNAMATE-4-HYDROXYLASE are caused by perturbations in auxin transport. New Phytologist. 230(6), 2275–2291.","short":"I. El Houari, C. Van Beirs, H. Arents, H. Han, A. Chanoca, D. Opdenacker, J. Pollier, V. Storme, W. Steenackers, M. Quareshy, R. Napier, T. Beeckman, J. Friml, B. De Rybel, W. Boerjan, B. Vanholme, New Phytologist 230 (2021) 2275–2291.","mla":"El Houari, I., et al. “Seedling Developmental Defects upon Blocking CINNAMATE-4-HYDROXYLASE Are Caused by Perturbations in Auxin Transport.” <i>New Phytologist</i>, vol. 230, no. 6, Wiley, 2021, pp. 2275–91, doi:<a href=\"https://doi.org/10.1111/nph.17349\">10.1111/nph.17349</a>.","apa":"El Houari, I., Van Beirs, C., Arents, H., Han, H., Chanoca, A., Opdenacker, D., … Vanholme, B. (2021). Seedling developmental defects upon blocking CINNAMATE-4-HYDROXYLASE are caused by perturbations in auxin transport. <i>New Phytologist</i>. Wiley. <a href=\"https://doi.org/10.1111/nph.17349\">https://doi.org/10.1111/nph.17349</a>","ama":"El Houari I, Van Beirs C, Arents H, et al. Seedling developmental defects upon blocking CINNAMATE-4-HYDROXYLASE are caused by perturbations in auxin transport. <i>New Phytologist</i>. 2021;230(6):2275-2291. doi:<a href=\"https://doi.org/10.1111/nph.17349\">10.1111/nph.17349</a>","ieee":"I. El Houari <i>et al.</i>, “Seedling developmental defects upon blocking CINNAMATE-4-HYDROXYLASE are caused by perturbations in auxin transport,” <i>New Phytologist</i>, vol. 230, no. 6. Wiley, pp. 2275–2291, 2021.","chicago":"El Houari, I, C Van Beirs, HE Arents, Huibin Han, A Chanoca, D Opdenacker, J Pollier, et al. “Seedling Developmental Defects upon Blocking CINNAMATE-4-HYDROXYLASE Are Caused by Perturbations in Auxin Transport.” <i>New Phytologist</i>. Wiley, 2021. <a href=\"https://doi.org/10.1111/nph.17349\">https://doi.org/10.1111/nph.17349</a>."},"language":[{"iso":"eng"}],"day":"17","publication_identifier":{"eissn":["1469-8137"],"issn":["0028-646x"]},"oa_version":"Published Version"},{"scopus_import":"1","article_type":"original","isi":1,"month":"03","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"project":[{"grant_number":"742985","call_identifier":"H2020","name":"Tracing Evolution of Auxin Transport and Polarity in Plants","_id":"261099A6-B435-11E9-9278-68D0E5697425"},{"_id":"26538374-B435-11E9-9278-68D0E5697425","name":"Molecular mechanisms of endocytic cargo recognition in plants","call_identifier":"FWF","grant_number":"I03630"}],"pmid":1,"issue":"9","_id":"9290","year":"2021","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","oa":1,"fulldoi":"https://doi.org/10.1016/j.cub.2021.02.028","publication":"Current Biology","has_accepted_license":"1","publication_status":"published","date_published":"2021-03-10T00:00:00Z","page":"1918-1930","type":"journal_article","ddc":["580"],"abstract":[{"lang":"eng","text":"Polar subcellular localization of the PIN exporters of the phytohormone auxin is a key determinant of directional, intercellular auxin transport and thus a central topic of both plant cell and developmental biology. Arabidopsis mutants lacking PID, a kinase that phosphorylates PINs, or the MAB4/MEL proteins of unknown molecular function display PIN polarity defects and phenocopy pin mutants, but mechanistic insights into how these factors convey PIN polarity are missing. Here, by combining protein biochemistry with quantitative live-cell imaging, we demonstrate that PINs, MAB4/MELs, and AGC kinases interact in the same complex at the plasma membrane. MAB4/MELs are recruited to the plasma membrane by the PINs and in concert with the AGC kinases maintain PIN polarity through limiting lateral diffusion-based escape of PINs from the polar domain. The PIN-MAB4/MEL-PID protein complex has self-reinforcing properties thanks to positive feedback between AGC kinase-mediated PIN phosphorylation and MAB4/MEL recruitment. We thus uncover the molecular mechanism by which AGC kinases and MAB4/MEL proteins regulate PIN localization and plant development."}],"file":[{"checksum":"b1723040ecfd8c81194185472eb62546","file_id":"9303","content_type":"application/pdf","success":1,"file_size":4324371,"relation":"main_file","access_level":"open_access","date_updated":"2021-04-01T10:53:42Z","date_created":"2021-04-01T10:53:42Z","file_name":"2021_CurrentBiology_Glanc.pdf","creator":"dernst"}],"title":"AGC kinases and MAB4/MEL proteins maintain PIN polarity by limiting lateral diffusion in plant cells","acknowledgement":"We acknowledge Ben Scheres, Christian Luschnig, and Claus Schwechheimer for sharing published material. We thank Monika Hrtyan and Dorota Jaworska at IST Austria and Gerda Lamers and Ward de Winter at IBL Netherlands for technical assistance; Corinna Hartinger, Jakub Hajný, Lesia Rodriguez, Mingyue Li, and Lindy Abas for experimental support; and the Bioimaging Facility at IST Austria and the Bioimaging Core at VIB for imaging support. We are grateful to Christian Luschnig, Lindy Abas, and Roman Pleskot for valuable discussions. We also acknowledge the EMBO for supporting M.G. with a long-term fellowship ( ALTF 1005-2019 ) during the finalization and revision of this manuscript in the laboratory of B.D.R., and we thank R. Pierik for allowing K.V.G. to work on this manuscript during a postdoc in his laboratory at Utrecht University. This work was supported by grants from the European Research Council under the European Union’s Seventh Framework Programme (ERC grant agreements 742985 to J.F., 714055 to B.D.R., and 803048 to M.F.), the Austrian Science Fund (FWF; I 3630-B25 to J.F.), Chemical Sciences (partly) financed by the Dutch Research Council (NWO-CW TOP 700.58.301 to R.O.), the Dutch Research Council (NWO-VICI 865.17.002 to R. Pierik), Grants-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology, Japan (KAKENHI grant 17K17595 to S.N.), the Ministry of Education, Youth and Sports of the Czech Republic (MŠMT project NPUI-LO1417 ), and a China Scholarship Council (to X.W.).","article_processing_charge":"No","volume":31,"citation":{"ama":"Glanc M, Van Gelderen K, Hörmayer L, et al. AGC kinases and MAB4/MEL proteins maintain PIN polarity by limiting lateral diffusion in plant cells. <i>Current Biology</i>. 2021;31(9):1918-1930. doi:<a href=\"https://doi.org/10.1016/j.cub.2021.02.028\">10.1016/j.cub.2021.02.028</a>","chicago":"Glanc, Matous, K Van Gelderen, Lukas Hörmayer, Shutang Tan, S Naramoto, Xixi Zhang, David Domjan, et al. “AGC Kinases and MAB4/MEL Proteins Maintain PIN Polarity by Limiting Lateral Diffusion in Plant Cells.” <i>Current Biology</i>. Elsevier, 2021. <a href=\"https://doi.org/10.1016/j.cub.2021.02.028\">https://doi.org/10.1016/j.cub.2021.02.028</a>.","ieee":"M. Glanc <i>et al.</i>, “AGC kinases and MAB4/MEL proteins maintain PIN polarity by limiting lateral diffusion in plant cells,” <i>Current Biology</i>, vol. 31, no. 9. Elsevier, pp. 1918–1930, 2021.","mla":"Glanc, Matous, et al. “AGC Kinases and MAB4/MEL Proteins Maintain PIN Polarity by Limiting Lateral Diffusion in Plant Cells.” <i>Current Biology</i>, vol. 31, no. 9, Elsevier, 2021, pp. 1918–30, doi:<a href=\"https://doi.org/10.1016/j.cub.2021.02.028\">10.1016/j.cub.2021.02.028</a>.","short":"M. Glanc, K. Van Gelderen, L. Hörmayer, S. Tan, S. Naramoto, X. Zhang, D. Domjan, L. Vcelarova, R. Hauschild, A.J. Johnson, E. de Koning, M. van Dop, E. Rademacher, S. Janson, X. Wei, G. Molnar, M. Fendrych, B. De Rybel, R. Offringa, J. Friml, Current Biology 31 (2021) 1918–1930.","apa":"Glanc, M., Van Gelderen, K., Hörmayer, L., Tan, S., Naramoto, S., Zhang, X., … Friml, J. (2021). AGC kinases and MAB4/MEL proteins maintain PIN polarity by limiting lateral diffusion in plant cells. <i>Current Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cub.2021.02.028\">https://doi.org/10.1016/j.cub.2021.02.028</a>","ista":"Glanc M, Van Gelderen K, Hörmayer L, Tan S, Naramoto S, Zhang X, Domjan D, Vcelarova L, Hauschild R, Johnson AJ, de Koning E, van Dop M, Rademacher E, Janson S, Wei X, Molnar G, Fendrych M, De Rybel B, Offringa R, Friml J. 2021. AGC kinases and MAB4/MEL proteins maintain PIN polarity by limiting lateral diffusion in plant cells. Current Biology. 31(9), 1918–1930."},"file_date_updated":"2021-04-01T10:53:42Z","language":[{"iso":"eng"}],"day":"10","publication_identifier":{"eissn":["1879-0445"],"issn":["0960-9822"]},"oa_version":"Published Version","corr_author":"1","department":[{"_id":"JiFr"}],"intvolume":"        31","external_id":{"isi":["000653077800004"],"pmid":["33705718"]},"acknowledged_ssus":[{"_id":"Bio"}],"quality_controlled":"1","doi":"10.1016/j.cub.2021.02.028","date_updated":"2025-04-14T07:45:00Z","author":[{"id":"1AE1EA24-02D0-11E9-9BAA-DAF4881429F2","last_name":"Glanc","full_name":"Glanc, Matous","first_name":"Matous","orcid":"0000-0003-0619-7783"},{"last_name":"Van Gelderen","full_name":"Van Gelderen, K","first_name":"K"},{"first_name":"Lukas","last_name":"Hörmayer","id":"2EEE7A2A-F248-11E8-B48F-1D18A9856A87","full_name":"Hörmayer, Lukas","orcid":"0000-0001-8295-2926"},{"first_name":"Shutang","id":"2DE75584-F248-11E8-B48F-1D18A9856A87","last_name":"Tan","full_name":"Tan, Shutang","orcid":"0000-0002-0471-8285"},{"full_name":"Naramoto, S","last_name":"Naramoto","first_name":"S"},{"first_name":"Xixi","last_name":"Zhang","full_name":"Zhang, Xixi","id":"61A66458-47E9-11EA-85BA-8AEAAF14E49A","orcid":"0000-0001-7048-4627"},{"orcid":"0000-0003-2267-106X","last_name":"Domjan","id":"C684CD7A-257E-11EA-9B6F-D8588B4F947F","full_name":"Domjan, David","first_name":"David"},{"last_name":"Vcelarova","full_name":"Vcelarova, L","first_name":"L"},{"last_name":"Hauschild","full_name":"Hauschild, Robert","id":"4E01D6B4-F248-11E8-B48F-1D18A9856A87","first_name":"Robert","orcid":"0000-0001-9843-3522"},{"first_name":"Alexander J","full_name":"Johnson, Alexander J","id":"46A62C3A-F248-11E8-B48F-1D18A9856A87","last_name":"Johnson","orcid":"0000-0002-2739-8843"},{"first_name":"E","full_name":"de Koning, E","last_name":"de Koning"},{"full_name":"van Dop, M","last_name":"van Dop","first_name":"M"},{"last_name":"Rademacher","full_name":"Rademacher, E","first_name":"E"},{"first_name":"S","full_name":"Janson, S","last_name":"Janson"},{"first_name":"X","full_name":"Wei, X","last_name":"Wei"},{"first_name":"Gergely","last_name":"Molnar","id":"34F1AF46-F248-11E8-B48F-1D18A9856A87","full_name":"Molnar, Gergely"},{"full_name":"Fendrych, Matyas","last_name":"Fendrych","id":"43905548-F248-11E8-B48F-1D18A9856A87","first_name":"Matyas","orcid":"0000-0002-9767-8699"},{"first_name":"B","last_name":"De Rybel","full_name":"De Rybel, B"},{"first_name":"R","last_name":"Offringa","full_name":"Offringa, R"},{"full_name":"Friml, Jiří","last_name":"Friml","id":"4159519E-F248-11E8-B48F-1D18A9856A87","first_name":"Jiří","orcid":"0000-0002-8302-7596"}],"ec_funded":1,"date_created":"2021-03-26T12:09:33Z","status":"public","publisher":"Elsevier"},{"has_accepted_license":"1","status":"public","ddc":["530"],"publisher":"Institute of Science and Technology Austria","type":"research_data","date_published":"2021-03-29T00:00:00Z","doi":"10.15479/AT:ISTA:9291","department":[{"_id":"GeKa"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","fulldoi":"https://doi.org/10.15479/AT:ISTA:9291","oa":1,"date_created":"2021-03-27T13:47:49Z","author":[{"first_name":"Georgios","last_name":"Katsaros","full_name":"Katsaros, Georgios","id":"38DB5788-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8342-202X"}],"date_updated":"2024-02-21T12:37:14Z","file_date_updated":"2021-04-01T07:52:56Z","_id":"9291","citation":{"ista":"Katsaros G. 2021. Raw transport data for: Enhancement of proximity induced superconductivity in planar germanium, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:9291\">10.15479/AT:ISTA:9291</a>.","ieee":"G. Katsaros, “Raw transport data for: Enhancement of proximity induced superconductivity in planar germanium.” Institute of Science and Technology Austria, 2021.","chicago":"Katsaros, Georgios. “Raw Transport Data for: Enhancement of Proximity Induced Superconductivity in Planar Germanium.” Institute of Science and Technology Austria, 2021. <a href=\"https://doi.org/10.15479/AT:ISTA:9291\">https://doi.org/10.15479/AT:ISTA:9291</a>.","ama":"Katsaros G. Raw transport data for: Enhancement of proximity induced superconductivity in planar germanium. 2021. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:9291\">10.15479/AT:ISTA:9291</a>","apa":"Katsaros, G. (2021). Raw transport data for: Enhancement of proximity induced superconductivity in planar germanium. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:9291\">https://doi.org/10.15479/AT:ISTA:9291</a>","mla":"Katsaros, Georgios. <i>Raw Transport Data for: Enhancement of Proximity Induced Superconductivity in Planar Germanium</i>. Institute of Science and Technology Austria, 2021, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:9291\">10.15479/AT:ISTA:9291</a>.","short":"G. Katsaros, (2021)."},"year":"2021","day":"29","oa_version":"Published Version","month":"03","abstract":[{"text":"This .zip File contains the transport data for figures presented in the main text and supplementary material of \"Enhancement of Proximity Induced Superconductivity in Planar Germanium\" by K. Aggarwal, et. al. \r\nThe measurements were done using Labber Software and the data is stored in the hdf5 file format. The files can be opened using either the Labber Log Browser (https://labber.org/overview/) or Labber Python API (http://labber.org/online-doc/api/LogFile.html).","lang":"eng"}],"file":[{"content_type":"application/x-zip-compressed","success":1,"file_id":"9292","checksum":"635df3c08fc13c3dac008cd421aefbe4","access_level":"open_access","file_name":"Raw Data- Enhancement of Superconductivity in a Planar Ge hole gas.zip","creator":"gkatsaro","date_created":"2021-03-27T13:46:17Z","date_updated":"2021-03-27T13:46:17Z","relation":"main_file","file_size":10616071},{"relation":"main_file","file_size":470,"date_updated":"2021-04-01T07:52:56Z","creator":"dernst","date_created":"2021-04-01T07:52:56Z","file_name":"README.txt","access_level":"open_access","file_id":"9302","checksum":"12b3ca69ae7509a346711baae0b02a75","success":1,"content_type":"text/plain"}],"title":"Raw transport data for: Enhancement of proximity induced superconductivity in planar germanium","tmp":{"short":"CC0 (1.0)","legal_code_url":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","name":"Creative Commons Public Domain Dedication (CC0 1.0)","image":"/images/cc_0.png"},"article_processing_charge":"No"},{"oa":1,"fulldoi":"https://doi.org/10.1016/j.devcel.2021.03.002","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","page":"723-725","ddc":["570"],"type":"journal_article","publication_status":"published","date_published":"2021-03-22T00:00:00Z","publication":"Developmental Cell","month":"03","isi":1,"scopus_import":"1","article_type":"original","year":"2021","_id":"9294","pmid":1,"issue":"6","date_created":"2021-03-28T22:01:41Z","date_updated":"2026-06-18T19:45:10Z","author":[{"orcid":"0000-0001-6120-3723","first_name":"Florian R","last_name":"Gärtner","id":"397A88EE-F248-11E8-B48F-1D18A9856A87","full_name":"Gärtner, Florian R"},{"orcid":"0000-0002-6620-9179","full_name":"Sixt, Michael K","last_name":"Sixt","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","first_name":"Michael K"}],"external_id":{"isi":["000631681200004"],"pmid":["33756118"]},"doi":"10.1016/j.devcel.2021.03.002","quality_controlled":"1","department":[{"_id":"MiSi"}],"corr_author":"1","intvolume":"        56","publisher":"Elsevier","status":"public","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1016/j.devcel.2021.03.002"}],"article_processing_charge":"No","abstract":[{"text":"In this issue of Developmental Cell, Doyle and colleagues identify periodic anterior contraction as a characteristic feature of fibroblasts and mesenchymal cancer cells embedded in 3D collagen gels. This contractile mechanism generates a matrix prestrain required for crawling in fibrous 3D environments.","lang":"eng"}],"title":"Engaging the front wheels to drive through fibrous terrain","day":"22","publication_identifier":{"issn":["1534-5807"],"eissn":["1878-1551"]},"oa_version":"Published Version","language":[{"iso":"eng"}],"volume":56,"citation":{"ista":"Gärtner FR, Sixt MK. 2021. Engaging the front wheels to drive through fibrous terrain. Developmental Cell. 56(6), 723–725.","ama":"Gärtner FR, Sixt MK. Engaging the front wheels to drive through fibrous terrain. <i>Developmental Cell</i>. 2021;56(6):723-725. doi:<a href=\"https://doi.org/10.1016/j.devcel.2021.03.002\">10.1016/j.devcel.2021.03.002</a>","ieee":"F. R. Gärtner and M. K. Sixt, “Engaging the front wheels to drive through fibrous terrain,” <i>Developmental Cell</i>, vol. 56, no. 6. Elsevier, pp. 723–725, 2021.","chicago":"Gärtner, Florian R, and Michael K Sixt. “Engaging the Front Wheels to Drive through Fibrous Terrain.” <i>Developmental Cell</i>. Elsevier, 2021. <a href=\"https://doi.org/10.1016/j.devcel.2021.03.002\">https://doi.org/10.1016/j.devcel.2021.03.002</a>.","short":"F.R. Gärtner, M.K. Sixt, Developmental Cell 56 (2021) 723–725.","mla":"Gärtner, Florian R., and Michael K. Sixt. “Engaging the Front Wheels to Drive through Fibrous Terrain.” <i>Developmental Cell</i>, vol. 56, no. 6, Elsevier, 2021, pp. 723–25, doi:<a href=\"https://doi.org/10.1016/j.devcel.2021.03.002\">10.1016/j.devcel.2021.03.002</a>.","apa":"Gärtner, F. R., &#38; Sixt, M. K. (2021). Engaging the front wheels to drive through fibrous terrain. <i>Developmental Cell</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.devcel.2021.03.002\">https://doi.org/10.1016/j.devcel.2021.03.002</a>"}},{"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","fulldoi":"https://doi.org/10.1002/jgt.22665","oa":1,"publication":"Journal of Graph Theory","arxiv":1,"page":"426-440","type":"journal_article","publication_status":"published","date_published":"2021-03-23T00:00:00Z","isi":1,"month":"03","article_type":"original","scopus_import":"1","project":[{"grant_number":"754411","name":"ISTplus - Postdoctoral Fellowships","_id":"260C2330-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"}],"_id":"9295","issue":"3","year":"2021","external_id":{"isi":["000631693200001"],"arxiv":["2002.02287"]},"doi":"10.1002/jgt.22665","quality_controlled":"1","department":[{"_id":"UlWa"}],"intvolume":"        97","author":[{"first_name":"Alan M","last_name":"Arroyo Guevara","id":"3207FDC6-F248-11E8-B48F-1D18A9856A87","full_name":"Arroyo Guevara, Alan M","orcid":"0000-0003-2401-8670"},{"last_name":"Mcquillan","full_name":"Mcquillan, Dan","first_name":"Dan"},{"last_name":"Richter","full_name":"Richter, R. Bruce","first_name":"R. Bruce"},{"first_name":"Gelasio","last_name":"Salazar","full_name":"Salazar, Gelasio"},{"last_name":"Sullivan","full_name":"Sullivan, Matthew","first_name":"Matthew"}],"ec_funded":1,"date_updated":"2025-04-14T07:43:51Z","date_created":"2021-03-28T22:01:41Z","status":"public","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/2002.02287"}],"publisher":"Wiley","acknowledgement":"We thank two reviewers for their corrections and suggestions on the original version of this\r\npaper. This project has received funding from NSERC Grant 50503-10940-500 and from the European Union’s Horizon 2020 research and innovation programme under the Marie SkłodowskaCurie grant agreement No 754411, IST, Klosterneuburg, Austria.","abstract":[{"text":"Hill's Conjecture states that the crossing number  cr(𝐾𝑛)  of the complete graph  𝐾𝑛  in the plane (equivalently, the sphere) is  14⌊𝑛2⌋⌊𝑛−12⌋⌊𝑛−22⌋⌊𝑛−32⌋=𝑛4/64+𝑂(𝑛3) . Moon proved that the expected number of crossings in a spherical drawing in which the points are randomly distributed and joined by geodesics is precisely  𝑛4/64+𝑂(𝑛3) , thus matching asymptotically the conjectured value of  cr(𝐾𝑛) . Let  cr𝑃(𝐺)  denote the crossing number of a graph  𝐺  in the projective plane. Recently, Elkies proved that the expected number of crossings in a naturally defined random projective plane drawing of  𝐾𝑛  is  (𝑛4/8𝜋2)+𝑂(𝑛3) . In analogy with the relation of Moon's result to Hill's conjecture, Elkies asked if  lim𝑛→∞ cr𝑃(𝐾𝑛)/𝑛4=1/8𝜋2 . We construct drawings of  𝐾𝑛  in the projective plane that disprove this.","lang":"eng"}],"title":"Drawings of complete graphs in the projective plane","article_processing_charge":"No","language":[{"iso":"eng"}],"volume":97,"citation":{"ieee":"A. M. Arroyo Guevara, D. Mcquillan, R. B. Richter, G. Salazar, and M. Sullivan, “Drawings of complete graphs in the projective plane,” <i>Journal of Graph Theory</i>, vol. 97, no. 3. Wiley, pp. 426–440, 2021.","chicago":"Arroyo Guevara, Alan M, Dan Mcquillan, R. Bruce Richter, Gelasio Salazar, and Matthew Sullivan. “Drawings of Complete Graphs in the Projective Plane.” <i>Journal of Graph Theory</i>. Wiley, 2021. <a href=\"https://doi.org/10.1002/jgt.22665\">https://doi.org/10.1002/jgt.22665</a>.","ama":"Arroyo Guevara AM, Mcquillan D, Richter RB, Salazar G, Sullivan M. Drawings of complete graphs in the projective plane. <i>Journal of Graph Theory</i>. 2021;97(3):426-440. doi:<a href=\"https://doi.org/10.1002/jgt.22665\">10.1002/jgt.22665</a>","apa":"Arroyo Guevara, A. M., Mcquillan, D., Richter, R. B., Salazar, G., &#38; Sullivan, M. (2021). Drawings of complete graphs in the projective plane. <i>Journal of Graph Theory</i>. Wiley. <a href=\"https://doi.org/10.1002/jgt.22665\">https://doi.org/10.1002/jgt.22665</a>","mla":"Arroyo Guevara, Alan M., et al. “Drawings of Complete Graphs in the Projective Plane.” <i>Journal of Graph Theory</i>, vol. 97, no. 3, Wiley, 2021, pp. 426–40, doi:<a href=\"https://doi.org/10.1002/jgt.22665\">10.1002/jgt.22665</a>.","short":"A.M. Arroyo Guevara, D. Mcquillan, R.B. Richter, G. Salazar, M. Sullivan, Journal of Graph Theory 97 (2021) 426–440.","ista":"Arroyo Guevara AM, Mcquillan D, Richter RB, Salazar G, Sullivan M. 2021. Drawings of complete graphs in the projective plane. Journal of Graph Theory. 97(3), 426–440."},"day":"23","oa_version":"Preprint","publication_identifier":{"issn":["0364-9024"],"eissn":["1097-0118"]}},{"_id":"9296","year":"2021","scopus_import":"1","month":"02","isi":1,"project":[{"grant_number":"754411","name":"ISTplus - Postdoctoral Fellowships","_id":"260C2330-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"},{"call_identifier":"FWF","_id":"268116B8-B435-11E9-9278-68D0E5697425","name":"Mathematics, Computer Science","grant_number":"Z00342"},{"grant_number":"279307","call_identifier":"FP7","name":"Quantitative Graph Games: Theory and Applications","_id":"2581B60A-B435-11E9-9278-68D0E5697425"},{"grant_number":"P 23499-N23","call_identifier":"FWF","name":"Modern Graph Algorithmic Techniques in Formal Verification","_id":"2584A770-B435-11E9-9278-68D0E5697425"},{"call_identifier":"FWF","_id":"25863FF4-B435-11E9-9278-68D0E5697425","name":"Game Theory","grant_number":"S11407"}],"publication":"15th International Conference on Algorithms and Computation","arxiv":1,"publication_status":"published","date_published":"2021-02-16T00:00:00Z","page":"221-233","type":"conference","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","oa":1,"fulldoi":"https://doi.org/10.1007/978-3-030-68211-8_18","volume":12635,"citation":{"ista":"Aichholzer O, Arroyo Guevara AM, Masárová Z, Parada I, Perz D, Pilz A, Tkadlec J, Vogtenhuber B. 2021. On compatible matchings. 15th International Conference on Algorithms and Computation. WALCOM: Algorithms and Computation, LNCS, vol. 12635, 221–233.","ama":"Aichholzer O, Arroyo Guevara AM, Masárová Z, et al. On compatible matchings. In: <i>15th International Conference on Algorithms and Computation</i>. Vol 12635. Springer Nature; 2021:221-233. doi:<a href=\"https://doi.org/10.1007/978-3-030-68211-8_18\">10.1007/978-3-030-68211-8_18</a>","chicago":"Aichholzer, Oswin, Alan M Arroyo Guevara, Zuzana Masárová, Irene Parada, Daniel Perz, Alexander Pilz, Josef Tkadlec, and Birgit Vogtenhuber. “On Compatible Matchings.” In <i>15th International Conference on Algorithms and Computation</i>, 12635:221–33. Springer Nature, 2021. <a href=\"https://doi.org/10.1007/978-3-030-68211-8_18\">https://doi.org/10.1007/978-3-030-68211-8_18</a>.","ieee":"O. Aichholzer <i>et al.</i>, “On compatible matchings,” in <i>15th International Conference on Algorithms and Computation</i>, Yangon, Myanmar, 2021, vol. 12635, pp. 221–233.","mla":"Aichholzer, Oswin, et al. “On Compatible Matchings.” <i>15th International Conference on Algorithms and Computation</i>, vol. 12635, Springer Nature, 2021, pp. 221–33, doi:<a href=\"https://doi.org/10.1007/978-3-030-68211-8_18\">10.1007/978-3-030-68211-8_18</a>.","short":"O. Aichholzer, A.M. Arroyo Guevara, Z. Masárová, I. Parada, D. Perz, A. Pilz, J. Tkadlec, B. Vogtenhuber, in:, 15th International Conference on Algorithms and Computation, Springer Nature, 2021, pp. 221–233.","apa":"Aichholzer, O., Arroyo Guevara, A. M., Masárová, Z., Parada, I., Perz, D., Pilz, A., … Vogtenhuber, B. (2021). On compatible matchings. In <i>15th International Conference on Algorithms and Computation</i> (Vol. 12635, pp. 221–233). Yangon, Myanmar: Springer Nature. <a href=\"https://doi.org/10.1007/978-3-030-68211-8_18\">https://doi.org/10.1007/978-3-030-68211-8_18</a>"},"conference":{"location":"Yangon, Myanmar","start_date":"2021-02-28","end_date":"2021-03-02","name":"WALCOM: Algorithms and Computation"},"alternative_title":["LNCS"],"language":[{"iso":"eng"}],"day":"16","oa_version":"Preprint","publication_identifier":{"isbn":["9783030682101"],"issn":["0302-9743"],"eissn":["1611-3349"],"eisbn":["9783030682118"]},"abstract":[{"text":" matching is compatible to two or more labeled point sets of size n with labels   {1,…,n}  if its straight-line drawing on each of these point sets is crossing-free. We study the maximum number of edges in a matching compatible to two or more labeled point sets in general position in the plane. We show that for any two labeled convex sets of n points there exists a compatible matching with   ⌊2n−−√⌋  edges. More generally, for any   ℓ  labeled point sets we construct compatible matchings of size   Ω(n1/ℓ) . As a corresponding upper bound, we use probabilistic arguments to show that for any   ℓ  given sets of n points there exists a labeling of each set such that the largest compatible matching has   O(n2/(ℓ+1))  edges. Finally, we show that   Θ(logn)  copies of any set of n points are necessary and sufficient for the existence of a labeling such that any compatible matching consists only of a single edge.","lang":"eng"}],"title":"On compatible matchings","related_material":{"record":[{"id":"11938","status":"public","relation":"later_version"}]},"acknowledgement":"A.A. funded by the Marie Skłodowska-Curie grant agreement No. 754411. Z.M. partially funded by Wittgenstein Prize, Austrian Science Fund (FWF), grant no. Z 342-N31. I.P., D.P., and B.V. partially supported by FWF within the collaborative DACH project Arrangements and Drawings as FWF project I 3340-N35. A.P. supported by a Schrödinger fellowship of the FWF: J-3847-N35. J.T. partially supported by ERC Start grant no. (279307: Graph Games), FWF grant no. P23499-N23 and S11407-N23 (RiSE).","article_processing_charge":"No","main_file_link":[{"url":"https://arxiv.org/abs/2101.03928","open_access":"1"}],"status":"public","publisher":"Springer Nature","department":[{"_id":"UlWa"},{"_id":"HeEd"},{"_id":"KrCh"}],"intvolume":"     12635","external_id":{"isi":["001435069600018"],"arxiv":["2101.03928"]},"quality_controlled":"1","doi":"10.1007/978-3-030-68211-8_18","date_created":"2021-03-28T22:01:41Z","ec_funded":1,"author":[{"first_name":"Oswin","last_name":"Aichholzer","full_name":"Aichholzer, Oswin"},{"orcid":"0000-0003-2401-8670","first_name":"Alan M","full_name":"Arroyo Guevara, Alan M","last_name":"Arroyo Guevara","id":"3207FDC6-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0002-6660-1322","first_name":"Zuzana","id":"45CFE238-F248-11E8-B48F-1D18A9856A87","full_name":"Masárová, Zuzana","last_name":"Masárová"},{"full_name":"Parada, Irene","last_name":"Parada","first_name":"Irene"},{"first_name":"Daniel","full_name":"Perz, Daniel","last_name":"Perz"},{"first_name":"Alexander","full_name":"Pilz, Alexander","last_name":"Pilz"},{"orcid":"0000-0002-1097-9684","full_name":"Tkadlec, Josef","last_name":"Tkadlec","id":"3F24CCC8-F248-11E8-B48F-1D18A9856A87","first_name":"Josef"},{"first_name":"Birgit","full_name":"Vogtenhuber, Birgit","last_name":"Vogtenhuber"}],"date_updated":"2026-04-16T09:18:21Z"},{"doi":"10.1017/jfm.2021.89","quality_controlled":"1","external_id":{"isi":["000629677500001"],"arxiv":["2008.08851"]},"intvolume":"       915","department":[{"_id":"BjHo"}],"date_updated":"2023-08-07T14:30:11Z","date_created":"2021-03-28T22:01:42Z","author":[{"first_name":"T.","last_name":"Liu","full_name":"Liu, T."},{"first_name":"B.","full_name":"Semin, B.","last_name":"Semin"},{"orcid":"0000-0003-1740-7635","id":"2C9AF1C2-F248-11E8-B48F-1D18A9856A87","last_name":"Klotz","full_name":"Klotz, Lukasz","first_name":"Lukasz"},{"full_name":"Godoy-Diana, R.","last_name":"Godoy-Diana","first_name":"R."},{"full_name":"Wesfreid, J. E.","last_name":"Wesfreid","first_name":"J. E."},{"full_name":"Mullin, T.","last_name":"Mullin","first_name":"T."}],"status":"public","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/2008.08851"}],"publisher":"Cambridge University Press","acknowledgement":"We gratefully acknowledge Joran Rolland, Yohann Duguet, Romain Monchaux, S´ebastien Gom´e, Laurette Tuckerman, Dwight Barkley, Olivier Dauchot and Sabine Bottin for fruitful discussions. We thank Xavier Benoit-Gonin, Amaury Fourgeaud, Thierry Darnige, Olivier Brouard and Justine Laurent for technical help. This work has benefited from the ANR TransFlow, and by starting grants obtained by B.S. from CNRS (INSIS) and ESPCI. T.M. was\r\nsupported by a Joliot visiting professorship grant from ESPCI.","title":"Decay of streaks and rolls in plane Couette-Poiseuille flow","abstract":[{"lang":"eng","text":"We report the results of an experimental investigation into the decay of turbulence in plane Couette–Poiseuille flow using ‘quench’ experiments where the flow laminarises after a sudden reduction in Reynolds number Re. Specifically, we study the velocity field in the streamwise–spanwise plane. We show that the spanwise velocity containing rolls decays faster than the streamwise velocity, which displays elongated regions of higher or lower velocity called streaks. At final Reynolds numbers above 425, the decay of streaks displays two stages: first a slow decay when rolls are present and secondly a more rapid decay of streaks alone. The difference in behaviour results from the regeneration of streaks by rolls, called the lift-up effect. We define the turbulent fraction as the portion of the flow containing turbulence and this is estimated by thresholding the spanwise velocity component. It decreases linearly with time in the whole range of final Re. The corresponding decay slope increases linearly with final Re. The extrapolated value at which this decay slope vanishes is Reaz≈656±10, close to Reg≈670 at which turbulence is self-sustained. The decay of the energy computed from the spanwise velocity component is found to be exponential. The corresponding decay rate increases linearly with Re, with an extrapolated vanishing value at ReAz≈688±10. This value is also close to the value at which the turbulence is self-sustained, showing that valuable information on the transition can be obtained over a wide range of Re."}],"article_processing_charge":"No","language":[{"iso":"eng"}],"citation":{"ieee":"T. Liu, B. Semin, L. Klotz, R. Godoy-Diana, J. E. Wesfreid, and T. Mullin, “Decay of streaks and rolls in plane Couette-Poiseuille flow,” <i>Journal of Fluid Mechanics</i>, vol. 915. Cambridge University Press, 2021.","chicago":"Liu, T., B. Semin, Lukasz Klotz, R. Godoy-Diana, J. E. Wesfreid, and T. Mullin. “Decay of Streaks and Rolls in Plane Couette-Poiseuille Flow.” <i>Journal of Fluid Mechanics</i>. Cambridge University Press, 2021. <a href=\"https://doi.org/10.1017/jfm.2021.89\">https://doi.org/10.1017/jfm.2021.89</a>.","ama":"Liu T, Semin B, Klotz L, Godoy-Diana R, Wesfreid JE, Mullin T. Decay of streaks and rolls in plane Couette-Poiseuille flow. <i>Journal of Fluid Mechanics</i>. 2021;915. doi:<a href=\"https://doi.org/10.1017/jfm.2021.89\">10.1017/jfm.2021.89</a>","apa":"Liu, T., Semin, B., Klotz, L., Godoy-Diana, R., Wesfreid, J. E., &#38; Mullin, T. (2021). Decay of streaks and rolls in plane Couette-Poiseuille flow. <i>Journal of Fluid Mechanics</i>. Cambridge University Press. <a href=\"https://doi.org/10.1017/jfm.2021.89\">https://doi.org/10.1017/jfm.2021.89</a>","short":"T. Liu, B. Semin, L. Klotz, R. Godoy-Diana, J.E. Wesfreid, T. Mullin, Journal of Fluid Mechanics 915 (2021).","mla":"Liu, T., et al. “Decay of Streaks and Rolls in Plane Couette-Poiseuille Flow.” <i>Journal of Fluid Mechanics</i>, vol. 915, A65, Cambridge University Press, 2021, doi:<a href=\"https://doi.org/10.1017/jfm.2021.89\">10.1017/jfm.2021.89</a>.","ista":"Liu T, Semin B, Klotz L, Godoy-Diana R, Wesfreid JE, Mullin T. 2021. Decay of streaks and rolls in plane Couette-Poiseuille flow. Journal of Fluid Mechanics. 915, A65."},"volume":915,"oa_version":"Preprint","publication_identifier":{"eissn":["1469-7645"],"issn":["0022-1120"]},"day":"17","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","oa":1,"fulldoi":"https://doi.org/10.1017/jfm.2021.89","arxiv":1,"publication":"Journal of Fluid Mechanics","type":"journal_article","date_published":"2021-03-17T00:00:00Z","publication_status":"published","month":"03","isi":1,"article_type":"original","scopus_import":"1","_id":"9297","article_number":"A65","year":"2021"},{"publisher":"National Academy of Sciences","status":"public","main_file_link":[{"url":"https://doi.org/10.26434/chemrxiv.11447775","open_access":"1"}],"date_created":"2021-03-31T07:00:01Z","author":[{"first_name":"Christian","last_name":"Prehal","full_name":"Prehal, Christian"},{"last_name":"Samojlov","full_name":"Samojlov, Aleksej","first_name":"Aleksej"},{"last_name":"Nachtnebel","full_name":"Nachtnebel, Manfred","first_name":"Manfred"},{"orcid":"0000-0001-6206-4200","first_name":"Ludek","last_name":"Lovicar","full_name":"Lovicar, Ludek","id":"36DB3A20-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Manfred","last_name":"Kriechbaum","full_name":"Kriechbaum, Manfred"},{"first_name":"Heinz","full_name":"Amenitsch, Heinz","last_name":"Amenitsch"},{"orcid":"0000-0003-2902-5319","last_name":"Freunberger","id":"A8CA28E6-CE23-11E9-AD2D-EC27E6697425","full_name":"Freunberger, Stefan Alexander","first_name":"Stefan Alexander"}],"date_updated":"2025-06-12T06:56:39Z","quality_controlled":"1","doi":"10.1073/pnas.2021893118","external_id":{"isi":["000637398300050"],"pmid":["33785597"]},"acknowledged_ssus":[{"_id":"EM-Fac"}],"intvolume":"       118","department":[{"_id":"StFr"},{"_id":"EM-Fac"}],"publication_identifier":{"issn":["0027-8424"],"eissn":["1091-6490"]},"oa_version":"Preprint","day":"06","language":[{"iso":"eng"}],"citation":{"ista":"Prehal C, Samojlov A, Nachtnebel M, Lovicar L, Kriechbaum M, Amenitsch H, Freunberger SA. 2021. In situ small-angle X-ray scattering reveals solution phase discharge of Li–O2 batteries with weakly solvating electrolytes. Proceedings of the National Academy of Sciences of the United States of America. 118(14), e2021893118.","mla":"Prehal, Christian, et al. “In Situ Small-Angle X-Ray Scattering Reveals Solution Phase Discharge of Li–O2 Batteries with Weakly Solvating Electrolytes.” <i>Proceedings of the National Academy of Sciences of the United States of America</i>, vol. 118, no. 14, e2021893118, National Academy of Sciences, 2021, doi:<a href=\"https://doi.org/10.1073/pnas.2021893118\">10.1073/pnas.2021893118</a>.","short":"C. Prehal, A. Samojlov, M. Nachtnebel, L. Lovicar, M. Kriechbaum, H. Amenitsch, S.A. Freunberger, Proceedings of the National Academy of Sciences of the United States of America 118 (2021).","apa":"Prehal, C., Samojlov, A., Nachtnebel, M., Lovicar, L., Kriechbaum, M., Amenitsch, H., &#38; Freunberger, S. A. (2021). In situ small-angle X-ray scattering reveals solution phase discharge of Li–O2 batteries with weakly solvating electrolytes. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.2021893118\">https://doi.org/10.1073/pnas.2021893118</a>","ama":"Prehal C, Samojlov A, Nachtnebel M, et al. In situ small-angle X-ray scattering reveals solution phase discharge of Li–O2 batteries with weakly solvating electrolytes. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. 2021;118(14). doi:<a href=\"https://doi.org/10.1073/pnas.2021893118\">10.1073/pnas.2021893118</a>","chicago":"Prehal, Christian, Aleksej Samojlov, Manfred Nachtnebel, Ludek Lovicar, Manfred Kriechbaum, Heinz Amenitsch, and Stefan Alexander Freunberger. “In Situ Small-Angle X-Ray Scattering Reveals Solution Phase Discharge of Li–O2 Batteries with Weakly Solvating Electrolytes.” <i>Proceedings of the National Academy of Sciences of the United States of America</i>. National Academy of Sciences, 2021. <a href=\"https://doi.org/10.1073/pnas.2021893118\">https://doi.org/10.1073/pnas.2021893118</a>.","ieee":"C. Prehal <i>et al.</i>, “In situ small-angle X-ray scattering reveals solution phase discharge of Li–O2 batteries with weakly solvating electrolytes,” <i>Proceedings of the National Academy of Sciences of the United States of America</i>, vol. 118, no. 14. National Academy of Sciences, 2021."},"volume":118,"article_processing_charge":"No","acknowledgement":"S.A.F. and C.P. are indebted to the European Research Council under the European Union's Horizon 2020 research and innovation program (Grant Agreement No. 636069), the Austrian Federal Ministry of Science, Research and Economy, and the Austrian Research Promotion Agency (Grant No. 845364). We acknowledge A. Zankel and H. Schroettner for support with SEM measurements. C.P. thanks N. Kostoglou, C. Koczwara, M. Hartmann, and M. Burian for discussions on gas sorption analysis, C++ programming, Monte Carlo modeling, and in situ SAXS experiments, respectively. We thank S. Stadlbauer for help with Karl Fischer titration, R. Riccò for gas sorption measurements, and acknowledge Graz University of Technology for support through the Lead Project LP-03. Likewise, the use of SOMAPP Lab, a core facility supported by the Austrian Federal Ministry of Education, Science and Research, the Graz University of Technology, the University of Graz, and Anton Paar GmbH is acknowledged. S.A.F. is indebted to Institute of Science and Technology Austria (IST Austria) for support. This research was supported by the Scientific Service Units of IST Austria through resources provided by the Electron Microscopy Facility.","title":"In situ small-angle X-ray scattering reveals solution phase discharge of Li–O2 batteries with weakly solvating electrolytes","abstract":[{"text":"Electrodepositing insulating lithium peroxide (Li2O2) is the key process during discharge of aprotic Li–O2 batteries and determines rate, capacity, and reversibility. Current understanding states that the partition between surface adsorbed and dissolved lithium superoxide governs whether Li2O2 grows as a conformal surface film or larger particles, leading to low or high capacities, respectively. However, better understanding governing factors for Li2O2 packing density and capacity requires structural sensitive in situ metrologies. Here, we establish in situ small- and wide-angle X-ray scattering (SAXS/WAXS) as a suitable method to record the Li2O2 phase evolution with atomic to submicrometer resolution during cycling a custom-built in situ Li–O2 cell. Combined with sophisticated data analysis, SAXS allows retrieving rich quantitative structural information from complex multiphase systems. Surprisingly, we find that features are absent that would point at a Li2O2 surface film formed via two consecutive electron transfers, even in poorly solvating electrolytes thought to be prototypical for surface growth. All scattering data can be modeled by stacks of thin Li2O2 platelets potentially forming large toroidal particles. Li2O2 solution growth is further justified by rotating ring-disk electrode measurements and electron microscopy. Higher discharge overpotentials lead to smaller Li2O2 particles, but there is no transition to an electronically passivating, conformal Li2O2 coating. Hence, mass transport of reactive species rather than electronic transport through a Li2O2 film limits the discharge capacity. Provided that species mobilities and carbon surface areas are high, this allows for high discharge capacities even in weakly solvating electrolytes. The currently accepted Li–O2 reaction mechanism ought to be reconsidered.","lang":"eng"}],"type":"journal_article","date_published":"2021-04-06T00:00:00Z","publication_status":"published","publication":"Proceedings of the National Academy of Sciences of the United States of America","fulldoi":"https://doi.org/10.1073/pnas.2021893118","oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_number":"e2021893118","year":"2021","_id":"9301","issue":"14","pmid":1,"keyword":["small-angle X-ray scattering","oxygen reduction","disproportionation","Li-air battery"],"month":"04","isi":1,"article_type":"original","scopus_import":"1"},{"ec_funded":1,"date_created":"2021-04-04T22:01:20Z","author":[{"first_name":"Yu","last_name":"Zhang","full_name":"Zhang, Yu"},{"last_name":"Xing","full_name":"Xing, Congcong","first_name":"Congcong"},{"orcid":"0000-0001-7313-6740","last_name":"Liu","full_name":"Liu, Yu","id":"2A70014E-F248-11E8-B48F-1D18A9856A87","first_name":"Yu"},{"first_name":"Mengyao","full_name":"Li, Mengyao","last_name":"Li"},{"full_name":"Xiao, Ke","last_name":"Xiao","first_name":"Ke"},{"full_name":"Guardia, Pablo","last_name":"Guardia","first_name":"Pablo"},{"last_name":"Lee","full_name":"Lee, Seungho","id":"BB243B88-D767-11E9-B658-BC13E6697425","first_name":"Seungho","orcid":"0000-0002-6962-8598"},{"last_name":"Han","full_name":"Han, Xu","first_name":"Xu"},{"last_name":"Moghaddam","full_name":"Moghaddam, Ahmad","first_name":"Ahmad"},{"first_name":"Joan J","full_name":"Roa, Joan J","last_name":"Roa"},{"full_name":"Arbiol, Jordi","last_name":"Arbiol","first_name":"Jordi"},{"first_name":"Maria","id":"43C61214-F248-11E8-B48F-1D18A9856A87","full_name":"Ibáñez, Maria","last_name":"Ibáñez","orcid":"0000-0001-5013-2843"},{"first_name":"Kai","full_name":"Pan, Kai","last_name":"Pan"},{"full_name":"Prato, Mirko","last_name":"Prato","first_name":"Mirko"},{"first_name":"Ying","last_name":"Xie","full_name":"Xie, Ying"},{"last_name":"Cabot","full_name":"Cabot, Andreu","first_name":"Andreu"}],"date_updated":"2025-04-14T07:43:52Z","external_id":{"isi":["000655672000005"]},"doi":"10.1016/j.cej.2021.129374","quality_controlled":"1","department":[{"_id":"MaIb"}],"intvolume":"       418","publisher":"Elsevier","status":"public","main_file_link":[{"url":"https://ddd.uab.cat/record/271949","open_access":"1"}],"article_processing_charge":"No","acknowledgement":"This work was supported by the European Regional Development Funds and by the Generalitat de Catalunya through the project 2017SGR1246. Y.Z, C.X, M.L, K.X and X.H thank the China Scholarship Council for the scholarship support. MI acknowledges financial support from IST Austria. YL acknowledges funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No. 754411. ICN2\r\nacknowledges funding from Generalitat de Catalunya 2017 SGR 327 and the Spanish MINECO project ENE2017-85087-C3. ICN2 is supported by the Severo Ochoa program from the Spanish MINECO (grant no. SEV-2017-0706) and is funded by the CERCA Program/Generalitat de Catalunya. Part of the present work has been performed in the framework of Universitat Autònoma de Barcelona Materials Science PhD program.","abstract":[{"lang":"eng","text":"The high processing cost, poor mechanical properties and moderate performance of Bi2Te3–based alloys used in thermoelectric devices limit the cost-effectiveness of this energy conversion technology. Towards solving these current challenges, in the present work, we detail a low temperature solution-based approach to produce Bi2Te3-Cu2-xTe nanocomposites with improved thermoelectric performance. Our approach consists in combining proper ratios of colloidal nanoparticles and to consolidate the resulting mixture into nanocomposites using a hot press. The transport properties of the nanocomposites are characterized and compared with those of pure Bi2Te3 nanomaterials obtained following the same procedure. In contrast with most previous works, the presence of Cu2-xTe nanodomains does not result in a significant reduction of the lattice thermal conductivity of the reference Bi2Te3 nanomaterial, which is already very low. However, the introduction of Cu2-xTe yields a nearly threefold increase of the power factor associated to a simultaneous increase of the Seebeck coefficient and electrical conductivity at temperatures above 400 K. Taking into account the band alignment of the two materials, we rationalize this increase by considering that Cu2-xTe nanostructures, with a relatively low electron affinity, are able to inject electrons into Bi2Te3, enhancing in this way its electrical conductivity. The simultaneous increase of the Seebeck coefficient is related to the energy filtering of charge carriers at energy barriers within Bi2Te3 domains associated with the accumulation of electrons in regions nearby a Cu2-xTe/Bi2Te3 heterojunction. Overall, with the incorporation of a proper amount of Cu2-xTe nanoparticles, we demonstrate a 250% improvement of the thermoelectric figure of merit of Bi2Te3."}],"title":"Influence of copper telluride nanodomains on the transport properties of n-type bismuth telluride","day":"15","oa_version":"Submitted Version","publication_identifier":{"issn":["1385-8947"]},"language":[{"iso":"eng"}],"volume":418,"citation":{"ista":"Zhang Y, Xing C, Liu Y, Li M, Xiao K, Guardia P, Lee S, Han X, Moghaddam A, Roa JJ, Arbiol J, Ibáñez M, Pan K, Prato M, Xie Y, Cabot A. 2021. Influence of copper telluride nanodomains on the transport properties of n-type bismuth telluride. Chemical Engineering Journal. 418(8), 129374.","chicago":"Zhang, Yu, Congcong Xing, Yu Liu, Mengyao Li, Ke Xiao, Pablo Guardia, Seungho Lee, et al. “Influence of Copper Telluride Nanodomains on the Transport Properties of N-Type Bismuth Telluride.” <i>Chemical Engineering Journal</i>. Elsevier, 2021. <a href=\"https://doi.org/10.1016/j.cej.2021.129374\">https://doi.org/10.1016/j.cej.2021.129374</a>.","ieee":"Y. Zhang <i>et al.</i>, “Influence of copper telluride nanodomains on the transport properties of n-type bismuth telluride,” <i>Chemical Engineering Journal</i>, vol. 418, no. 8. Elsevier, 2021.","ama":"Zhang Y, Xing C, Liu Y, et al. Influence of copper telluride nanodomains on the transport properties of n-type bismuth telluride. <i>Chemical Engineering Journal</i>. 2021;418(8). doi:<a href=\"https://doi.org/10.1016/j.cej.2021.129374\">10.1016/j.cej.2021.129374</a>","apa":"Zhang, Y., Xing, C., Liu, Y., Li, M., Xiao, K., Guardia, P., … Cabot, A. (2021). Influence of copper telluride nanodomains on the transport properties of n-type bismuth telluride. <i>Chemical Engineering Journal</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cej.2021.129374\">https://doi.org/10.1016/j.cej.2021.129374</a>","short":"Y. Zhang, C. Xing, Y. Liu, M. Li, K. Xiao, P. Guardia, S. Lee, X. Han, A. Moghaddam, J.J. Roa, J. Arbiol, M. Ibáñez, K. Pan, M. Prato, Y. Xie, A. Cabot, Chemical Engineering Journal 418 (2021).","mla":"Zhang, Yu, et al. “Influence of Copper Telluride Nanodomains on the Transport Properties of N-Type Bismuth Telluride.” <i>Chemical Engineering Journal</i>, vol. 418, no. 8, 129374, Elsevier, 2021, doi:<a href=\"https://doi.org/10.1016/j.cej.2021.129374\">10.1016/j.cej.2021.129374</a>."},"fulldoi":"https://doi.org/10.1016/j.cej.2021.129374","oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","type":"journal_article","publication_status":"published","date_published":"2021-08-15T00:00:00Z","publication":"Chemical Engineering Journal","project":[{"_id":"260C2330-B435-11E9-9278-68D0E5697425","name":"ISTplus - Postdoctoral Fellowships","call_identifier":"H2020","grant_number":"754411"}],"month":"08","isi":1,"article_type":"original","scopus_import":"1","year":"2021","article_number":"129374","_id":"9304","issue":"8"},{"corr_author":"1","department":[{"_id":"MaIb"}],"intvolume":"        85","external_id":{"isi":["000663442200004"]},"quality_controlled":"1","doi":"10.1016/j.nanoen.2021.105991","date_updated":"2025-04-14T07:43:52Z","date_created":"2021-04-04T22:01:21Z","ec_funded":1,"author":[{"first_name":"Yu","last_name":"Zhang","full_name":"Zhang, Yu"},{"first_name":"Congcong","last_name":"Xing","full_name":"Xing, Congcong"},{"orcid":"0000-0001-7313-6740","first_name":"Yu","full_name":"Liu, Yu","last_name":"Liu","id":"2A70014E-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Spadaro, Maria Chiara","last_name":"Spadaro","first_name":"Maria Chiara"},{"first_name":"Xiang","last_name":"Wang","full_name":"Wang, Xiang"},{"full_name":"Li, Mengyao","last_name":"Li","first_name":"Mengyao"},{"first_name":"Ke","last_name":"Xiao","full_name":"Xiao, Ke"},{"first_name":"Ting","full_name":"Zhang, Ting","last_name":"Zhang"},{"first_name":"Pablo","last_name":"Guardia","full_name":"Guardia, Pablo"},{"first_name":"Khak Ho","last_name":"Lim","full_name":"Lim, Khak Ho"},{"first_name":"Ahmad Ostovari","full_name":"Moghaddam, Ahmad Ostovari","last_name":"Moghaddam"},{"first_name":"Jordi","full_name":"Llorca, Jordi","last_name":"Llorca"},{"first_name":"Jordi","last_name":"Arbiol","full_name":"Arbiol, Jordi"},{"id":"43C61214-F248-11E8-B48F-1D18A9856A87","full_name":"Ibáñez, Maria","last_name":"Ibáñez","first_name":"Maria","orcid":"0000-0001-5013-2843"},{"full_name":"Cabot, Andreu","last_name":"Cabot","first_name":"Andreu"}],"main_file_link":[{"open_access":"1","url":"https://ddd.uab.cat/record/271947"}],"status":"public","publisher":"Elsevier","abstract":[{"text":"Copper chalcogenides are outstanding thermoelectric materials for applications in the medium-high temperature range. Among different chalcogenides, while Cu2−xSe is characterized by higher thermoelectric figures of merit, Cu2−xS provides advantages in terms of low cost and element abundance. In the present work, we investigate the effect of different dopants to enhance the Cu2−xS performance and also its thermal stability. Among the tested options, Pb-doped Cu2−xS shows the highest improvement in stability against sulfur volatilization. Additionally, Pb incorporation allows tuning charge carrier concentration, which enables a significant improvement of the power factor. We demonstrate here that the introduction of an optimal additive amount of just 0.3% results in a threefold increase of the power factor in the middle-temperature range (500–800 K) and a record dimensionless thermoelectric figure of merit above 2 at 880 K.","lang":"eng"}],"title":"Doping-mediated stabilization of copper vacancies to promote thermoelectric properties of Cu2-xS","acknowledgement":"This work was supported by the European Regional Development Fund and by the Spanish Ministerio de Economía y Competitividad through the project SEHTOP (ENE2016-77798-C4-3-R). MI acknowledges financial support from IST Austria. YL acknowledges funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No. 754411. YZ, CX, XW, KX and TZ thank the China Scholarship Council for the scholarship support. ICN2 acknowledges funding from Generalitat de Catalunya 2017 SGR 327 and the Spanish MINECO project ENE2017-85087-C3. ICN2 is supported by the Severo Ochoa program from the Spanish MINECO (grant no. SEV-2017-0706) and is funded by the CERCA program/Generalitat de Catalunya. Part of the present work has been performed in the framework of Universitat Autònoma de Barcelona Materials Science Ph.D. program. M.C.S. has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 754510 (PROBIST) and the Severo Ochoa programme. P.G. acknowledges financial support from the Spanish government (MICIU) through the RTI2018-102006-J-I00 project and the Catalan Agency of Competitiveness (ACCIO) through the TecnioSpring+ Marie Sklodowska-Curie action TECSPR16-1-0082. YZ and CX contributed equally to this work.","article_processing_charge":"No","volume":85,"citation":{"mla":"Zhang, Yu, et al. “Doping-Mediated Stabilization of Copper Vacancies to Promote Thermoelectric Properties of Cu2-XS.” <i>Nano Energy</i>, vol. 85, no. 7, 105991, Elsevier, 2021, doi:<a href=\"https://doi.org/10.1016/j.nanoen.2021.105991\">10.1016/j.nanoen.2021.105991</a>.","short":"Y. Zhang, C. Xing, Y. Liu, M.C. Spadaro, X. Wang, M. Li, K. Xiao, T. Zhang, P. Guardia, K.H. Lim, A.O. Moghaddam, J. Llorca, J. Arbiol, M. Ibáñez, A. Cabot, Nano Energy 85 (2021).","apa":"Zhang, Y., Xing, C., Liu, Y., Spadaro, M. C., Wang, X., Li, M., … Cabot, A. (2021). Doping-mediated stabilization of copper vacancies to promote thermoelectric properties of Cu2-xS. <i>Nano Energy</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.nanoen.2021.105991\">https://doi.org/10.1016/j.nanoen.2021.105991</a>","ama":"Zhang Y, Xing C, Liu Y, et al. Doping-mediated stabilization of copper vacancies to promote thermoelectric properties of Cu2-xS. <i>Nano Energy</i>. 2021;85(7). doi:<a href=\"https://doi.org/10.1016/j.nanoen.2021.105991\">10.1016/j.nanoen.2021.105991</a>","chicago":"Zhang, Yu, Congcong Xing, Yu Liu, Maria Chiara Spadaro, Xiang Wang, Mengyao Li, Ke Xiao, et al. “Doping-Mediated Stabilization of Copper Vacancies to Promote Thermoelectric Properties of Cu2-XS.” <i>Nano Energy</i>. Elsevier, 2021. <a href=\"https://doi.org/10.1016/j.nanoen.2021.105991\">https://doi.org/10.1016/j.nanoen.2021.105991</a>.","ieee":"Y. Zhang <i>et al.</i>, “Doping-mediated stabilization of copper vacancies to promote thermoelectric properties of Cu2-xS,” <i>Nano Energy</i>, vol. 85, no. 7. Elsevier, 2021.","ista":"Zhang Y, Xing C, Liu Y, Spadaro MC, Wang X, Li M, Xiao K, Zhang T, Guardia P, Lim KH, Moghaddam AO, Llorca J, Arbiol J, Ibáñez M, Cabot A. 2021. Doping-mediated stabilization of copper vacancies to promote thermoelectric properties of Cu2-xS. Nano Energy. 85(7), 105991."},"language":[{"iso":"eng"}],"day":"01","oa_version":"Submitted Version","publication_identifier":{"issn":["2211-2855"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","fulldoi":"https://doi.org/10.1016/j.nanoen.2021.105991","oa":1,"publication":"Nano Energy","publication_status":"published","date_published":"2021-07-01T00:00:00Z","type":"journal_article","scopus_import":"1","article_type":"original","month":"07","isi":1,"project":[{"grant_number":"754411","call_identifier":"H2020","name":"ISTplus - Postdoctoral Fellowships","_id":"260C2330-B435-11E9-9278-68D0E5697425"}],"issue":"7","_id":"9305","year":"2021","article_number":"105991"},{"oa":1,"fulldoi":"https://doi.org/10.1083/jcb.202003052","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","date_published":"2021-03-19T00:00:00Z","publication_status":"published","ddc":["576"],"type":"journal_article","publication":"Journal of Cell Biology","has_accepted_license":"1","project":[{"call_identifier":"FWF","name":"Active mechano-chemical description of the cell cytoskeleton","_id":"268294B6-B435-11E9-9278-68D0E5697425","grant_number":"P31639"}],"tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"article_type":"original","scopus_import":"1","isi":1,"month":"03","article_number":"e202003052","year":"2021","issue":"4","pmid":1,"_id":"9306","date_created":"2021-04-04T22:01:21Z","author":[{"first_name":"Ulrich","last_name":"Dobramysl","full_name":"Dobramysl, Ulrich"},{"first_name":"Iris Katharina","full_name":"Jarsch, Iris Katharina","last_name":"Jarsch"},{"full_name":"Inoue, Yoshiko","last_name":"Inoue","first_name":"Yoshiko"},{"last_name":"Shimo","full_name":"Shimo, Hanae","first_name":"Hanae"},{"full_name":"Richier, Benjamin","last_name":"Richier","first_name":"Benjamin"},{"first_name":"Jonathan R.","last_name":"Gadsby","full_name":"Gadsby, Jonathan R."},{"last_name":"Mason","full_name":"Mason, Julia","first_name":"Julia"},{"first_name":"Alicja","last_name":"Szałapak","full_name":"Szałapak, Alicja"},{"full_name":"Ioannou, Pantelis Savvas","last_name":"Ioannou","first_name":"Pantelis Savvas"},{"first_name":"Guilherme Pereira","last_name":"Correia","full_name":"Correia, Guilherme Pereira"},{"last_name":"Walrant","full_name":"Walrant, Astrid","first_name":"Astrid"},{"first_name":"Richard","full_name":"Butler, Richard","last_name":"Butler"},{"first_name":"Edouard B","full_name":"Hannezo, Edouard B","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","last_name":"Hannezo","orcid":"0000-0001-6005-1561"},{"full_name":"Simons, Benjamin D.","last_name":"Simons","first_name":"Benjamin D."},{"last_name":"Gallop","full_name":"Gallop, Jennifer L.","first_name":"Jennifer L."}],"date_updated":"2026-04-02T13:59:43Z","intvolume":"       220","department":[{"_id":"EdHa"}],"quality_controlled":"1","doi":"10.1083/jcb.202003052","external_id":{"isi":["000663160600002"],"pmid":["33740033"]},"publisher":"Rockefeller University Press","status":"public","article_processing_charge":"No","title":"Stochastic combinations of actin regulatory proteins are sufficient to drive filopodia formation","file":[{"file_name":"2021_JCB_Dobramysl.pdf","date_updated":"2021-04-06T10:39:08Z","date_created":"2021-04-06T10:39:08Z","creator":"dernst","access_level":"open_access","file_size":9019720,"relation":"main_file","success":1,"content_type":"application/pdf","checksum":"4739ffd90f2c7e05ac5b00f057c58aa2","file_id":"9310"}],"abstract":[{"lang":"eng","text":"Assemblies of actin and its regulators underlie the dynamic morphology of all eukaryotic cells. To understand how actin regulatory proteins work together to generate actin-rich structures such as filopodia, we analyzed the localization of diverse actin regulators within filopodia in Drosophila embryos and in a complementary in vitro system of filopodia-like structures (FLSs). We found that the composition of the regulatory protein complex where actin is incorporated (the filopodial tip complex) is remarkably heterogeneous both in vivo and in vitro. Our data reveal that different pairs of proteins correlate with each other and with actin bundle length, suggesting the presence of functional subcomplexes. This is consistent with a theoretical framework where three or more redundant subcomplexes join the tip complex stochastically, with any two being sufficient to drive filopodia formation. We provide an explanation for the observed heterogeneity and suggest that a mechanism based on multiple components allows stereotypical filopodial dynamics to arise from diverse upstream signaling pathways."}],"acknowledgement":"This work was supported by European Research Council grant 281971, Wellcome Trust Research Career Development Fellowship WT095829AIA and Wellcome Trust Senior Research\r\nFellowship 219482/Z/19/Z to J.L. Gallop, a Wellcome Trust Senior Investigator Award 098357 to B.D. Simons, and an Austrian Science Fund grant (P31639) to E. Hannezo. We acknowledge\r\ncore funding by the Wellcome Trust (092096) and Cancer Research UK (C6946/A14492). U. Dobramysl was supported by a Wellcome Trust Junior Interdisciplinary Fellowship grant\r\n(105602/Z/14/Z) and a Herchel Smith Postdoctoral Fellowship. H. Shimo was supported by a Funai Foundation Overseas scholarship.","oa_version":"Published Version","publication_identifier":{"eissn":["1540-8140"]},"day":"19","citation":{"ista":"Dobramysl U, Jarsch IK, Inoue Y, Shimo H, Richier B, Gadsby JR, Mason J, Szałapak A, Ioannou PS, Correia GP, Walrant A, Butler R, Hannezo EB, Simons BD, Gallop JL. 2021. Stochastic combinations of actin regulatory proteins are sufficient to drive filopodia formation. Journal of Cell Biology. 220(4), e202003052.","ama":"Dobramysl U, Jarsch IK, Inoue Y, et al. Stochastic combinations of actin regulatory proteins are sufficient to drive filopodia formation. <i>Journal of Cell Biology</i>. 2021;220(4). doi:<a href=\"https://doi.org/10.1083/jcb.202003052\">10.1083/jcb.202003052</a>","chicago":"Dobramysl, Ulrich, Iris Katharina Jarsch, Yoshiko Inoue, Hanae Shimo, Benjamin Richier, Jonathan R. Gadsby, Julia Mason, et al. “Stochastic Combinations of Actin Regulatory Proteins Are Sufficient to Drive Filopodia Formation.” <i>Journal of Cell Biology</i>. Rockefeller University Press, 2021. <a href=\"https://doi.org/10.1083/jcb.202003052\">https://doi.org/10.1083/jcb.202003052</a>.","ieee":"U. Dobramysl <i>et al.</i>, “Stochastic combinations of actin regulatory proteins are sufficient to drive filopodia formation,” <i>Journal of Cell Biology</i>, vol. 220, no. 4. Rockefeller University Press, 2021.","short":"U. Dobramysl, I.K. Jarsch, Y. Inoue, H. Shimo, B. Richier, J.R. Gadsby, J. Mason, A. Szałapak, P.S. Ioannou, G.P. Correia, A. Walrant, R. Butler, E.B. Hannezo, B.D. Simons, J.L. Gallop, Journal of Cell Biology 220 (2021).","mla":"Dobramysl, Ulrich, et al. “Stochastic Combinations of Actin Regulatory Proteins Are Sufficient to Drive Filopodia Formation.” <i>Journal of Cell Biology</i>, vol. 220, no. 4, e202003052, Rockefeller University Press, 2021, doi:<a href=\"https://doi.org/10.1083/jcb.202003052\">10.1083/jcb.202003052</a>.","apa":"Dobramysl, U., Jarsch, I. K., Inoue, Y., Shimo, H., Richier, B., Gadsby, J. R., … Gallop, J. L. (2021). Stochastic combinations of actin regulatory proteins are sufficient to drive filopodia formation. <i>Journal of Cell Biology</i>. Rockefeller University Press. <a href=\"https://doi.org/10.1083/jcb.202003052\">https://doi.org/10.1083/jcb.202003052</a>"},"volume":220,"file_date_updated":"2021-04-06T10:39:08Z","language":[{"iso":"eng"}]},{"_id":"9307","year":"2021","month":"03","isi":1,"article_type":"original","scopus_import":"1","project":[{"call_identifier":"H2020","name":"International IST Doctoral Program","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","grant_number":"665385"}],"tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"has_accepted_license":"1","publication":"Stochastics and Partial Differential Equations: Analysis and Computations","type":"journal_article","ddc":["510"],"page":"892–939","date_published":"2021-03-21T00:00:00Z","publication_status":"published","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","oa":1,"fulldoi":"https://doi.org/10.1007/s40072-021-00188-9","file_date_updated":"2021-04-06T09:31:28Z","language":[{"iso":"eng"}],"citation":{"mla":"Hensel, Sebastian. “Finite Time Extinction for the 1D Stochastic Porous Medium Equation with Transport Noise.” <i>Stochastics and Partial Differential Equations: Analysis and Computations</i>, vol. 9, Springer Nature, 2021, pp. 892–939, doi:<a href=\"https://doi.org/10.1007/s40072-021-00188-9\">10.1007/s40072-021-00188-9</a>.","short":"S. Hensel, Stochastics and Partial Differential Equations: Analysis and Computations 9 (2021) 892–939.","apa":"Hensel, S. (2021). Finite time extinction for the 1D stochastic porous medium equation with transport noise. <i>Stochastics and Partial Differential Equations: Analysis and Computations</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s40072-021-00188-9\">https://doi.org/10.1007/s40072-021-00188-9</a>","ama":"Hensel S. Finite time extinction for the 1D stochastic porous medium equation with transport noise. <i>Stochastics and Partial Differential Equations: Analysis and Computations</i>. 2021;9:892–939. doi:<a href=\"https://doi.org/10.1007/s40072-021-00188-9\">10.1007/s40072-021-00188-9</a>","ieee":"S. Hensel, “Finite time extinction for the 1D stochastic porous medium equation with transport noise,” <i>Stochastics and Partial Differential Equations: Analysis and Computations</i>, vol. 9. Springer Nature, pp. 892–939, 2021.","chicago":"Hensel, Sebastian. “Finite Time Extinction for the 1D Stochastic Porous Medium Equation with Transport Noise.” <i>Stochastics and Partial Differential Equations: Analysis and Computations</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1007/s40072-021-00188-9\">https://doi.org/10.1007/s40072-021-00188-9</a>.","ista":"Hensel S. 2021. Finite time extinction for the 1D stochastic porous medium equation with transport noise. Stochastics and Partial Differential Equations: Analysis and Computations. 9, 892–939."},"volume":9,"oa_version":"Published Version","publication_identifier":{"eissn":["2194-041X"],"issn":["2194-0401"]},"day":"21","acknowledgement":"This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie Grant Agreement No. 665385 . I am very grateful to M. Gerencsér and J. Maas for proposing this problem as well as helpful discussions. Special thanks go to F. Cornalba for suggesting the additional κ-truncation in Proposition 5. I am also indebted to an anonymous referee for pointing out a gap in a previous version of the proof of Lemma 9 (concerning the treatment of the noise term). The issue is resolved in this version.","title":"Finite time extinction for the 1D stochastic porous medium equation with transport noise","abstract":[{"text":"We establish finite time extinction with probability one for weak solutions of the Cauchy–Dirichlet problem for the 1D stochastic porous medium equation with Stratonovich transport noise and compactly supported smooth initial datum. Heuristically, this is expected to hold because Brownian motion has average spread rate O(t12) whereas the support of solutions to the deterministic PME grows only with rate O(t1m+1). The rigorous proof relies on a contraction principle up to time-dependent shift for Wong–Zakai type approximations, the transformation to a deterministic PME with two copies of a Brownian path as the lateral boundary, and techniques from the theory of viscosity solutions.","lang":"eng"}],"file":[{"access_level":"open_access","file_name":"2021_StochPartDiffEquation_Hensel.pdf","date_created":"2021-04-06T09:31:28Z","date_updated":"2021-04-06T09:31:28Z","creator":"dernst","relation":"main_file","file_size":727005,"content_type":"application/pdf","success":1,"file_id":"9309","checksum":"6529b609c9209861720ffa4685111bc6"}],"article_processing_charge":"Yes (via OA deal)","status":"public","publisher":"Springer Nature","doi":"10.1007/s40072-021-00188-9","quality_controlled":"1","external_id":{"isi":["000631001700001"]},"intvolume":"         9","department":[{"_id":"JuFi"}],"author":[{"orcid":"0000-0001-7252-8072","first_name":"Sebastian","last_name":"Hensel","id":"4D23B7DA-F248-11E8-B48F-1D18A9856A87","full_name":"Hensel, Sebastian"}],"ec_funded":1,"date_created":"2021-04-04T22:01:21Z","date_updated":"2025-03-31T16:00:58Z"},{"day":"25","oa_version":"None","publication_identifier":{"eissn":["1420-9012"],"issn":["1422-6383"]},"volume":76,"citation":{"ama":"Iyiola OS, Shehu Y. New convergence results for inertial Krasnoselskii–Mann iterations in Hilbert spaces with applications. <i>Results in Mathematics</i>. 2021;76(2). doi:<a href=\"https://doi.org/10.1007/s00025-021-01381-x\">10.1007/s00025-021-01381-x</a>","ieee":"O. S. Iyiola and Y. Shehu, “New convergence results for inertial Krasnoselskii–Mann iterations in Hilbert spaces with applications,” <i>Results in Mathematics</i>, vol. 76, no. 2. Springer Nature, 2021.","chicago":"Iyiola, Olaniyi S., and Yekini Shehu. “New Convergence Results for Inertial Krasnoselskii–Mann Iterations in Hilbert Spaces with Applications.” <i>Results in Mathematics</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1007/s00025-021-01381-x\">https://doi.org/10.1007/s00025-021-01381-x</a>.","mla":"Iyiola, Olaniyi S., and Yekini Shehu. “New Convergence Results for Inertial Krasnoselskii–Mann Iterations in Hilbert Spaces with Applications.” <i>Results in Mathematics</i>, vol. 76, no. 2, 75, Springer Nature, 2021, doi:<a href=\"https://doi.org/10.1007/s00025-021-01381-x\">10.1007/s00025-021-01381-x</a>.","short":"O.S. Iyiola, Y. Shehu, Results in Mathematics 76 (2021).","apa":"Iyiola, O. S., &#38; Shehu, Y. (2021). New convergence results for inertial Krasnoselskii–Mann iterations in Hilbert spaces with applications. <i>Results in Mathematics</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s00025-021-01381-x\">https://doi.org/10.1007/s00025-021-01381-x</a>","ista":"Iyiola OS, Shehu Y. 2021. New convergence results for inertial Krasnoselskii–Mann iterations in Hilbert spaces with applications. Results in Mathematics. 76(2), 75."},"language":[{"iso":"eng"}],"article_processing_charge":"No","abstract":[{"text":"We consider inertial iteration methods for Fermat–Weber location problem and primal–dual three-operator splitting in real Hilbert spaces. To do these, we first obtain weak convergence analysis and nonasymptotic O(1/n) convergence rate of the inertial Krasnoselskii–Mann iteration for fixed point of nonexpansive operators in infinite dimensional real Hilbert spaces under some seemingly easy to implement conditions on the iterative parameters. One of our contributions is that the convergence analysis and rate of convergence results are obtained using conditions which appear not complicated and restrictive as assumed in other previous related results in the literature. We then show that Fermat–Weber location problem and primal–dual three-operator splitting are special cases of fixed point problem of nonexpansive mapping and consequently obtain the convergence analysis of inertial iteration methods for Fermat–Weber location problem and primal–dual three-operator splitting in real Hilbert spaces. Some numerical implementations are drawn from primal–dual three-operator splitting to support the theoretical analysis.","lang":"eng"}],"title":"New convergence results for inertial Krasnoselskii–Mann iterations in Hilbert spaces with applications","acknowledgement":"The research of this author is supported by the Postdoctoral Fellowship from Institute of Science and Technology (IST), Austria.","publisher":"Springer Nature","status":"public","author":[{"last_name":"Iyiola","full_name":"Iyiola, Olaniyi S.","first_name":"Olaniyi S."},{"orcid":"0000-0001-9224-7139","id":"3FC7CB58-F248-11E8-B48F-1D18A9856A87","last_name":"Shehu","full_name":"Shehu, Yekini","first_name":"Yekini"}],"date_created":"2021-04-11T22:01:14Z","date_updated":"2024-10-09T21:00:33Z","corr_author":"1","department":[{"_id":"VlKo"}],"intvolume":"        76","external_id":{"isi":["000632917700001"]},"doi":"10.1007/s00025-021-01381-x","quality_controlled":"1","year":"2021","article_number":"75","issue":"2","_id":"9315","scopus_import":"1","article_type":"original","isi":1,"month":"03","publication_status":"published","date_published":"2021-03-25T00:00:00Z","type":"journal_article","publication":"Results in Mathematics","fulldoi":"https://doi.org/10.1007/s00025-021-01381-x","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"},{"day":"01","publication_identifier":{"eissn":["1097-4172"],"issn":["0092-8674"]},"oa_version":"Published Version","file_date_updated":"2021-06-08T10:04:10Z","language":[{"iso":"eng"}],"volume":184,"citation":{"ista":"Petridou N, Corominas-Murtra B, Heisenberg C-PJ, Hannezo EB. 2021. Rigidity percolation uncovers a structural basis for embryonic tissue phase transitions. Cell. 184(7), 1914–1928.e19.","ama":"Petridou N, Corominas-Murtra B, Heisenberg C-PJ, Hannezo EB. Rigidity percolation uncovers a structural basis for embryonic tissue phase transitions. <i>Cell</i>. 2021;184(7):1914-1928.e19. doi:<a href=\"https://doi.org/10.1016/j.cell.2021.02.017\">10.1016/j.cell.2021.02.017</a>","ieee":"N. Petridou, B. Corominas-Murtra, C.-P. J. Heisenberg, and E. B. Hannezo, “Rigidity percolation uncovers a structural basis for embryonic tissue phase transitions,” <i>Cell</i>, vol. 184, no. 7. Elsevier, p. 1914–1928.e19, 2021.","chicago":"Petridou, Nicoletta, Bernat Corominas-Murtra, Carl-Philipp J Heisenberg, and Edouard B Hannezo. “Rigidity Percolation Uncovers a Structural Basis for Embryonic Tissue Phase Transitions.” <i>Cell</i>. Elsevier, 2021. <a href=\"https://doi.org/10.1016/j.cell.2021.02.017\">https://doi.org/10.1016/j.cell.2021.02.017</a>.","mla":"Petridou, Nicoletta, et al. “Rigidity Percolation Uncovers a Structural Basis for Embryonic Tissue Phase Transitions.” <i>Cell</i>, vol. 184, no. 7, Elsevier, 2021, p. 1914–1928.e19, doi:<a href=\"https://doi.org/10.1016/j.cell.2021.02.017\">10.1016/j.cell.2021.02.017</a>.","short":"N. Petridou, B. Corominas-Murtra, C.-P.J. Heisenberg, E.B. Hannezo, Cell 184 (2021) 1914–1928.e19.","apa":"Petridou, N., Corominas-Murtra, B., Heisenberg, C.-P. J., &#38; Hannezo, E. B. (2021). Rigidity percolation uncovers a structural basis for embryonic tissue phase transitions. <i>Cell</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cell.2021.02.017\">https://doi.org/10.1016/j.cell.2021.02.017</a>"},"article_processing_charge":"No","acknowledgement":"We thank Carl Goodrich and the members of the Heisenberg and Hannezo groups, in particular Reka Korei, for help, technical advice, and discussions; and the Bioimaging and zebrafish facilities of the IST Austria for continuous support. This work was supported by the Elise Richter Program of Austrian Science Fund (FWF) to N.I.P. ( V 736-B26 ) and the European Union (European Research Council Advanced Grant 742573 to C.-P.H. and European Research Council Starting Grant 851288 to E.H.).","related_material":{"link":[{"url":"https://ist.ac.at/en/news/embryonic-tissue-undergoes-phase-transition/","description":"News on IST Homepage","relation":"press_release"}]},"abstract":[{"lang":"eng","text":"Embryo morphogenesis is impacted by dynamic changes in tissue material properties, which have been proposed to occur via processes akin to phase transitions (PTs). Here, we show that rigidity percolation provides a simple and robust theoretical framework to predict material/structural PTs of embryonic tissues from local cell connectivity. By using percolation theory, combined with directly monitoring dynamic changes in tissue rheology and cell contact mechanics, we demonstrate that the zebrafish blastoderm undergoes a genuine rigidity PT, brought about by a small reduction in adhesion-dependent cell connectivity below a critical value. We quantitatively predict and experimentally verify hallmarks of PTs, including power-law exponents and associated discontinuities of macroscopic observables. Finally, we show that this uniform PT depends on blastoderm cells undergoing meta-synchronous divisions causing random and, consequently, uniform changes in cell connectivity. Collectively, our theoretical and experimental findings reveal the structural basis of material PTs in an organismal context."}],"file":[{"success":1,"content_type":"application/pdf","checksum":"1e5295fbd9c2a459173ec45a0e8a7c2e","file_id":"9534","date_created":"2021-06-08T10:04:10Z","file_name":"2021_Cell_Petridou.pdf","creator":"cziletti","date_updated":"2021-06-08T10:04:10Z","access_level":"open_access","file_size":11405875,"relation":"main_file"}],"title":"Rigidity percolation uncovers a structural basis for embryonic tissue phase transitions","publisher":"Elsevier","status":"public","ec_funded":1,"date_created":"2021-04-11T22:01:14Z","author":[{"orcid":"0000-0002-8451-1195","first_name":"Nicoletta","id":"2A003F6C-F248-11E8-B48F-1D18A9856A87","last_name":"Petridou","full_name":"Petridou, Nicoletta"},{"orcid":"0000-0001-9806-5643","last_name":"Corominas-Murtra","id":"43BE2298-F248-11E8-B48F-1D18A9856A87","full_name":"Corominas-Murtra, Bernat","first_name":"Bernat"},{"orcid":"0000-0002-0912-4566","first_name":"Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87","full_name":"Heisenberg, Carl-Philipp J","last_name":"Heisenberg"},{"id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","last_name":"Hannezo","full_name":"Hannezo, Edouard B","first_name":"Edouard B","orcid":"0000-0001-6005-1561"}],"date_updated":"2025-07-10T12:01:42Z","external_id":{"isi":["000636734000022"],"pmid":["33730596"]},"acknowledged_ssus":[{"_id":"Bio"},{"_id":"PreCl"}],"quality_controlled":"1","doi":"10.1016/j.cell.2021.02.017","department":[{"_id":"CaHe"},{"_id":"EdHa"}],"corr_author":"1","intvolume":"       184","year":"2021","_id":"9316","pmid":1,"issue":"7","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"project":[{"grant_number":"742573","_id":"260F1432-B435-11E9-9278-68D0E5697425","name":"Interaction and feedback between cell mechanics and fate specification in vertebrate gastrulation","call_identifier":"H2020"},{"grant_number":"851288","_id":"05943252-7A3F-11EA-A408-12923DDC885E","name":"Design Principles of Branching Morphogenesis","call_identifier":"H2020"},{"call_identifier":"FWF","_id":"2693FD8C-B435-11E9-9278-68D0E5697425","name":"Tissue material properties in embryonic development","grant_number":"V00736"}],"month":"04","isi":1,"article_type":"original","scopus_import":"1","page":"1914-1928.e19","type":"journal_article","ddc":["570"],"publication_status":"published","date_published":"2021-04-01T00:00:00Z","publication":"Cell","has_accepted_license":"1","fulldoi":"https://doi.org/10.1016/j.cell.2021.02.017","oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"},{"pmid":1,"_id":"9317","year":"2021","article_type":"original","scopus_import":"1","month":"03","isi":1,"project":[{"grant_number":"788183","_id":"266A2E9E-B435-11E9-9278-68D0E5697425","name":"Alpha Shape Theory Extended","call_identifier":"H2020"},{"_id":"2561EBF4-B435-11E9-9278-68D0E5697425","name":"Persistence and stability of geometric complexes","call_identifier":"FWF","grant_number":"I02979-N35"}],"tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"publication":"Discrete and Computational Geometry","has_accepted_license":"1","date_published":"2021-03-31T00:00:00Z","publication_status":"published","type":"journal_article","ddc":["516"],"page":"1296–1313","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","fulldoi":"https://doi.org/10.1007/s00454-021-00281-9","oa":1,"citation":{"ista":"Edelsbrunner H, Osang GF. 2021. The multi-cover persistence of Euclidean balls. Discrete and Computational Geometry. 65, 1296–1313.","ama":"Edelsbrunner H, Osang GF. The multi-cover persistence of Euclidean balls. <i>Discrete and Computational Geometry</i>. 2021;65:1296–1313. doi:<a href=\"https://doi.org/10.1007/s00454-021-00281-9\">10.1007/s00454-021-00281-9</a>","ieee":"H. Edelsbrunner and G. F. Osang, “The multi-cover persistence of Euclidean balls,” <i>Discrete and Computational Geometry</i>, vol. 65. Springer Nature, pp. 1296–1313, 2021.","chicago":"Edelsbrunner, Herbert, and Georg F Osang. “The Multi-Cover Persistence of Euclidean Balls.” <i>Discrete and Computational Geometry</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1007/s00454-021-00281-9\">https://doi.org/10.1007/s00454-021-00281-9</a>.","short":"H. Edelsbrunner, G.F. Osang, Discrete and Computational Geometry 65 (2021) 1296–1313.","mla":"Edelsbrunner, Herbert, and Georg F. Osang. “The Multi-Cover Persistence of Euclidean Balls.” <i>Discrete and Computational Geometry</i>, vol. 65, Springer Nature, 2021, pp. 1296–1313, doi:<a href=\"https://doi.org/10.1007/s00454-021-00281-9\">10.1007/s00454-021-00281-9</a>.","apa":"Edelsbrunner, H., &#38; Osang, G. F. (2021). The multi-cover persistence of Euclidean balls. <i>Discrete and Computational Geometry</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s00454-021-00281-9\">https://doi.org/10.1007/s00454-021-00281-9</a>"},"volume":65,"language":[{"iso":"eng"}],"file_date_updated":"2021-12-01T10:56:53Z","oa_version":"Published Version","publication_identifier":{"eissn":["1432-0444"],"issn":["0179-5376"]},"day":"31","title":"The multi-cover persistence of Euclidean balls","file":[{"success":1,"content_type":"application/pdf","checksum":"59b4e1e827e494209bcb4aae22e1d347","file_id":"10394","file_name":"2021_DisCompGeo_Edelsbrunner_Osang.pdf","creator":"cchlebak","date_created":"2021-12-01T10:56:53Z","date_updated":"2021-12-01T10:56:53Z","access_level":"open_access","file_size":677704,"relation":"main_file"}],"abstract":[{"lang":"eng","text":"Given a locally finite X⊆Rd and a radius r≥0, the k-fold cover of X and r consists of all points in Rd that have k or more points of X within distance r. We consider two filtrations—one in scale obtained by fixing k and increasing r, and the other in depth obtained by fixing r and decreasing k—and we compute the persistence diagrams of both. While standard methods suffice for the filtration in scale, we need novel geometric and topological concepts for the filtration in depth. In particular, we introduce a rhomboid tiling in Rd+1 whose horizontal integer slices are the order-k Delaunay mosaics of X, and construct a zigzag module of Delaunay mosaics that is isomorphic to the persistence module of the multi-covers."}],"related_material":{"record":[{"status":"public","id":"187","relation":"earlier_version"}]},"acknowledgement":"This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant Agreement No. 78818 Alpha), and by the DFG Collaborative Research Center TRR 109, ‘Discretization in Geometry and Dynamics’, through Grant No. I02979-N35 of the Austrian Science Fund (FWF)\r\nOpen Access funding provided by the Institute of Science and Technology (IST Austria).","article_processing_charge":"Yes (via OA deal)","status":"public","publisher":"Springer Nature","intvolume":"        65","corr_author":"1","department":[{"_id":"HeEd"}],"quality_controlled":"1","doi":"10.1007/s00454-021-00281-9","external_id":{"pmid":["34720303"],"isi":["000635460400001"]},"author":[{"last_name":"Edelsbrunner","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","full_name":"Edelsbrunner, Herbert","first_name":"Herbert","orcid":"0000-0002-9823-6833"},{"first_name":"Georg F","full_name":"Osang, Georg F","id":"464B40D6-F248-11E8-B48F-1D18A9856A87","last_name":"Osang","orcid":"0000-0002-8882-5116"}],"date_updated":"2025-06-12T06:36:54Z","ec_funded":1,"date_created":"2021-04-11T22:01:15Z"},{"publisher":"Cambridge University Press","status":"public","date_created":"2021-04-11T22:01:15Z","ec_funded":1,"author":[{"first_name":"Lea","full_name":"Bossmann, Lea","last_name":"Bossmann","id":"A2E3BCBE-5FCC-11E9-AA4B-76F3E5697425","orcid":"0000-0002-6854-1343"},{"orcid":"0000-0002-9166-5889","id":"40AC02DC-F248-11E8-B48F-1D18A9856A87","full_name":"Petrat, Sören P","last_name":"Petrat","first_name":"Sören P"},{"full_name":"Seiringer, Robert","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","last_name":"Seiringer","first_name":"Robert","orcid":"0000-0002-6781-0521"}],"date_updated":"2026-04-02T14:02:29Z","department":[{"_id":"RoSe"}],"intvolume":"         9","external_id":{"isi":["000634006900001"]},"quality_controlled":"1","doi":"10.1017/fms.2021.22","day":"26","publication_identifier":{"eissn":["2050-5094"]},"oa_version":"Published Version","volume":9,"citation":{"ieee":"L. Bossmann, S. P. Petrat, and R. Seiringer, “Asymptotic expansion of low-energy excitations for weakly interacting bosons,” <i>Forum of Mathematics, Sigma</i>, vol. 9. Cambridge University Press, 2021.","chicago":"Bossmann, Lea, Sören P Petrat, and Robert Seiringer. “Asymptotic Expansion of Low-Energy Excitations for Weakly Interacting Bosons.” <i>Forum of Mathematics, Sigma</i>. Cambridge University Press, 2021. <a href=\"https://doi.org/10.1017/fms.2021.22\">https://doi.org/10.1017/fms.2021.22</a>.","ama":"Bossmann L, Petrat SP, Seiringer R. Asymptotic expansion of low-energy excitations for weakly interacting bosons. <i>Forum of Mathematics, Sigma</i>. 2021;9. doi:<a href=\"https://doi.org/10.1017/fms.2021.22\">10.1017/fms.2021.22</a>","apa":"Bossmann, L., Petrat, S. P., &#38; Seiringer, R. (2021). Asymptotic expansion of low-energy excitations for weakly interacting bosons. <i>Forum of Mathematics, Sigma</i>. Cambridge University Press. <a href=\"https://doi.org/10.1017/fms.2021.22\">https://doi.org/10.1017/fms.2021.22</a>","short":"L. Bossmann, S.P. Petrat, R. Seiringer, Forum of Mathematics, Sigma 9 (2021).","mla":"Bossmann, Lea, et al. “Asymptotic Expansion of Low-Energy Excitations for Weakly Interacting Bosons.” <i>Forum of Mathematics, Sigma</i>, vol. 9, e28, Cambridge University Press, 2021, doi:<a href=\"https://doi.org/10.1017/fms.2021.22\">10.1017/fms.2021.22</a>.","ista":"Bossmann L, Petrat SP, Seiringer R. 2021. Asymptotic expansion of low-energy excitations for weakly interacting bosons. Forum of Mathematics, Sigma. 9, e28."},"file_date_updated":"2021-04-12T07:15:58Z","language":[{"iso":"eng"}],"article_processing_charge":"Yes (via OA deal)","file":[{"relation":"main_file","file_size":883851,"date_updated":"2021-04-12T07:15:58Z","creator":"dernst","file_name":"2021_ForumMath_Bossmann.pdf","date_created":"2021-04-12T07:15:58Z","access_level":"open_access","file_id":"9319","checksum":"17a3e6786d1e930cf0c14a880a6d7e92","success":1,"content_type":"application/pdf"}],"abstract":[{"text":"We consider a system of N bosons in the mean-field scaling regime for a class of interactions including the repulsive Coulomb potential. We derive an asymptotic expansion of the low-energy eigenstates and the corresponding energies, which provides corrections to Bogoliubov theory to any order in 1/N.","lang":"eng"}],"title":"Asymptotic expansion of low-energy excitations for weakly interacting bosons","acknowledgement":"The first author gratefully acknowledges funding from the European Union’s Horizon 2020 research and innovation programme under Marie Skłodowska-Curie Grant Agreement No. 754411. The third author was supported by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant Agreement No. 694227).","publication_status":"published","date_published":"2021-03-26T00:00:00Z","type":"journal_article","ddc":["510"],"publication":"Forum of Mathematics, Sigma","has_accepted_license":"1","fulldoi":"https://doi.org/10.1017/fms.2021.22","oa":1,"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","year":"2021","article_number":"e28","_id":"9318","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"project":[{"call_identifier":"H2020","_id":"260C2330-B435-11E9-9278-68D0E5697425","name":"ISTplus - Postdoctoral Fellowships","grant_number":"754411"},{"_id":"25C6DC12-B435-11E9-9278-68D0E5697425","name":"Analysis of quantum many-body systems","call_identifier":"H2020","grant_number":"694227"}],"scopus_import":"1","article_type":"original","month":"03","isi":1},{"tmp":{"short":"CC0 (1.0)","legal_code_url":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","name":"Creative Commons Public Domain Dedication (CC0 1.0)","image":"/images/cc_0.png"},"article_processing_charge":"No","abstract":[{"lang":"eng","text":"This .zip File contains the data for figures presented in the main text and supplementary material of \"A singlet triplet hole spin qubit in planar Ge\" by D. Jirovec, et. al. The measurements were done using Labber Software and the data is stored in the hdf5 file format. The files can be opened using either the Labber Log Browser (https://labber.org/overview/) or Labber Python API (http://labber.org/online-doc/api/LogFile.html). A single file is acquired with QCodes and features the corresponding data type. XRD data are in .dat format and a code to open the data is provided. The code for simulations is as well provided in Python."}],"file":[{"relation":"main_file","file_size":221832287,"access_level":"open_access","creator":"djirovec","file_name":"DataRepositorySTqubit.zip","date_updated":"2021-04-14T09:48:47Z","date_created":"2021-04-14T09:48:47Z","checksum":"c569d2a2ce1694445cdbca19cf8ae023","file_id":"9324","content_type":"application/x-zip-compressed","success":1},{"file_id":"9325","checksum":"845bdf87430718ad6aff47eda7b5fc92","success":1,"content_type":"application/octet-stream","relation":"main_file","file_size":4323,"creator":"djirovec","date_updated":"2021-04-14T09:49:30Z","date_created":"2021-04-14T09:49:30Z","file_name":"ReadMe","access_level":"open_access"}],"title":"Research data for \"A singlet-triplet hole spin qubit planar Ge\"","related_material":{"record":[{"status":"public","id":"8909","relation":"used_in_publication"}]},"month":"04","day":"14","oa_version":"Published Version","year":"2021","citation":{"ista":"Jirovec D. 2021. Research data for ‘A singlet-triplet hole spin qubit planar Ge’, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:9323\">10.15479/AT:ISTA:9323</a>.","ama":"Jirovec D. Research data for “A singlet-triplet hole spin qubit planar Ge.” 2021. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:9323\">10.15479/AT:ISTA:9323</a>","chicago":"Jirovec, Daniel. “Research Data for ‘A Singlet-Triplet Hole Spin Qubit Planar Ge.’” Institute of Science and Technology Austria, 2021. <a href=\"https://doi.org/10.15479/AT:ISTA:9323\">https://doi.org/10.15479/AT:ISTA:9323</a>.","ieee":"D. Jirovec, “Research data for ‘A singlet-triplet hole spin qubit planar Ge.’” Institute of Science and Technology Austria, 2021.","short":"D. Jirovec, (2021).","mla":"Jirovec, Daniel. <i>Research Data for “A Singlet-Triplet Hole Spin Qubit Planar Ge.”</i> Institute of Science and Technology Austria, 2021, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:9323\">10.15479/AT:ISTA:9323</a>.","apa":"Jirovec, D. (2021). Research data for “A singlet-triplet hole spin qubit planar Ge.” Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:9323\">https://doi.org/10.15479/AT:ISTA:9323</a>"},"file_date_updated":"2021-04-14T09:49:30Z","_id":"9323","contributor":[{"contributor_type":"project_member","last_name":"Jirovec","id":"4C473F58-F248-11E8-B48F-1D18A9856A87","first_name":"Daniel"}],"fulldoi":"https://doi.org/10.15479/AT:ISTA:9323","oa":1,"date_updated":"2025-06-12T06:57:18Z","date_created":"2021-04-14T09:50:22Z","author":[{"orcid":"0000-0002-7197-4801","id":"4C473F58-F248-11E8-B48F-1D18A9856A87","full_name":"Jirovec, Daniel","last_name":"Jirovec","first_name":"Daniel"}],"department":[{"_id":"GradSch"},{"_id":"GeKa"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","doi":"10.15479/AT:ISTA:9323","date_published":"2021-04-14T00:00:00Z","publisher":"Institute of Science and Technology Austria","ddc":["530"],"type":"research_data","has_accepted_license":"1","status":"public"},{"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","department":[{"_id":"GradSch"},{"_id":"ChWo"}],"doi":"10.15479/AT:ISTA:9327","date_updated":"2026-06-18T19:57:47Z","date_created":"2021-04-16T14:26:19Z","author":[{"first_name":"Georg","full_name":"Sperl, Georg","last_name":"Sperl","id":"4DD40360-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Narain, Rahul","last_name":"Narain","first_name":"Rahul"},{"orcid":"0000-0001-6646-5546","first_name":"Christopher J","id":"3C61F1D2-F248-11E8-B48F-1D18A9856A87","last_name":"Wojtan","full_name":"Wojtan, Christopher J"}],"fulldoi":"https://doi.org/10.15479/AT:ISTA:9327","oa":1,"has_accepted_license":"1","status":"public","date_published":"2021-05-01T00:00:00Z","publisher":"IST Austria","type":"software","ddc":["005"],"title":"Mechanics-Aware Deformation of Yarn Pattern Geometry (Additional Animation/Model Data)","file":[{"file_id":"9328","checksum":"0324cb519273371708743f3282e7c081","success":1,"content_type":"application/zip","relation":"main_file","file_size":802586232,"creator":"gsperl","file_name":"MADYPG_extra_data.zip","date_created":"2021-04-16T14:15:12Z","date_updated":"2021-04-16T14:15:12Z","access_level":"open_access"},{"access_level":"open_access","date_updated":"2021-04-26T09:33:44Z","date_created":"2021-04-26T09:33:44Z","creator":"pub-gitlab-bot","file_name":"MADYPG.zip","relation":"main_file","file_size":64962865,"content_type":"application/gzip","checksum":"4c224551adf852b136ec21a4e13f0c1b","file_id":"9353"}],"abstract":[{"lang":"eng","text":"This archive contains the missing sweater mesh animations and displacement models for the code of \"Mechanics-Aware Deformation of Yarn Pattern Geometry\"\r\n\r\nCode Repository: https://git.ist.ac.at/gsperl/MADYPG"}],"license":"https://opensource.org/licenses/MIT","related_material":{"record":[{"relation":"used_for_analysis_in","id":"9818","status":"public"}]},"month":"05","gitlab_commit_id":"6a77e7e22769230ae5f5edaa090fb4b828e57573","gitlab_url":"https://git.ist.ac.at/gsperl/MADYPG","tmp":{"name":"The MIT License","legal_code_url":"https://opensource.org/licenses/MIT","short":"MIT"},"citation":{"ama":"Sperl G, Narain R, Wojtan C. Mechanics-Aware Deformation of Yarn Pattern Geometry (Additional Animation/Model Data). 2021. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:9327\">10.15479/AT:ISTA:9327</a>","chicago":"Sperl, Georg, Rahul Narain, and Chris Wojtan. “Mechanics-Aware Deformation of Yarn Pattern Geometry (Additional Animation/Model Data).” IST Austria, 2021. <a href=\"https://doi.org/10.15479/AT:ISTA:9327\">https://doi.org/10.15479/AT:ISTA:9327</a>.","ieee":"G. Sperl, R. Narain, and C. Wojtan, “Mechanics-Aware Deformation of Yarn Pattern Geometry (Additional Animation/Model Data).” IST Austria, 2021.","mla":"Sperl, Georg, et al. <i>Mechanics-Aware Deformation of Yarn Pattern Geometry (Additional Animation/Model Data)</i>. IST Austria, 2021, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:9327\">10.15479/AT:ISTA:9327</a>.","short":"G. Sperl, R. Narain, C. Wojtan, (2021).","apa":"Sperl, G., Narain, R., &#38; Wojtan, C. (2021). Mechanics-Aware Deformation of Yarn Pattern Geometry (Additional Animation/Model Data). IST Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:9327\">https://doi.org/10.15479/AT:ISTA:9327</a>","ista":"Sperl G, Narain R, Wojtan C. 2021. Mechanics-Aware Deformation of Yarn Pattern Geometry (Additional Animation/Model Data), IST Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:9327\">10.15479/AT:ISTA:9327</a>."},"_id":"9327","file_date_updated":"2021-04-26T09:33:44Z","year":"2021"},{"publication_identifier":{"eissn":["1872-678X"],"issn":["0165-0270"]},"oa_version":"Published Version","day":"09","language":[{"iso":"eng"}],"file_date_updated":"2021-04-19T08:30:22Z","citation":{"ista":"Zhang X, Schlögl A, Vandael DH, Jonas PM. 2021. MOD: A novel machine-learning optimal-filtering method for accurate and efficient detection of subthreshold synaptic events in vivo. Journal of Neuroscience Methods. 357(6), 109125.","apa":"Zhang, X., Schlögl, A., Vandael, D. H., &#38; Jonas, P. M. (2021). MOD: A novel machine-learning optimal-filtering method for accurate and efficient detection of subthreshold synaptic events in vivo. <i>Journal of Neuroscience Methods</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.jneumeth.2021.109125\">https://doi.org/10.1016/j.jneumeth.2021.109125</a>","mla":"Zhang, Xiaomin, et al. “MOD: A Novel Machine-Learning Optimal-Filtering Method for Accurate and Efficient Detection of Subthreshold Synaptic Events in Vivo.” <i>Journal of Neuroscience Methods</i>, vol. 357, no. 6, 109125, Elsevier, 2021, doi:<a href=\"https://doi.org/10.1016/j.jneumeth.2021.109125\">10.1016/j.jneumeth.2021.109125</a>.","short":"X. Zhang, A. Schlögl, D.H. Vandael, P.M. Jonas, Journal of Neuroscience Methods 357 (2021).","ieee":"X. Zhang, A. Schlögl, D. H. Vandael, and P. M. Jonas, “MOD: A novel machine-learning optimal-filtering method for accurate and efficient detection of subthreshold synaptic events in vivo,” <i>Journal of Neuroscience Methods</i>, vol. 357, no. 6. Elsevier, 2021.","chicago":"Zhang, Xiaomin, Alois Schlögl, David H Vandael, and Peter M Jonas. “MOD: A Novel Machine-Learning Optimal-Filtering Method for Accurate and Efficient Detection of Subthreshold Synaptic Events in Vivo.” <i>Journal of Neuroscience Methods</i>. Elsevier, 2021. <a href=\"https://doi.org/10.1016/j.jneumeth.2021.109125\">https://doi.org/10.1016/j.jneumeth.2021.109125</a>.","ama":"Zhang X, Schlögl A, Vandael DH, Jonas PM. MOD: A novel machine-learning optimal-filtering method for accurate and efficient detection of subthreshold synaptic events in vivo. <i>Journal of Neuroscience Methods</i>. 2021;357(6). doi:<a href=\"https://doi.org/10.1016/j.jneumeth.2021.109125\">10.1016/j.jneumeth.2021.109125</a>"},"volume":357,"article_processing_charge":"Yes (via OA deal)","acknowledgement":"This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement number 692692 to P.J.) and the Fond zur Förderung der Wissenschaftlichen Forschung (Z 312-B27, Wittgenstein award to P.J.). We thank Drs. Jozsef Csicsvari, Christoph Lampert, and Federico Stella for critically reading previous manuscript versions. We are also grateful to Drs. Josh Merel and Ben Shababo for their help with applying the Bayesian detection method to our data. We also thank Florian Marr for technical assistance, Eleftheria Kralli-Beller for manuscript editing, and the Scientific Service Units of IST Austria for efficient support.","title":"MOD: A novel machine-learning optimal-filtering method for accurate and efficient detection of subthreshold synaptic events in vivo","file":[{"success":1,"content_type":"application/pdf","checksum":"2a5800d91b96d08b525e17319dcd5e44","file_id":"9339","date_created":"2021-04-19T08:30:22Z","date_updated":"2021-04-19T08:30:22Z","creator":"dernst","file_name":"2021_JourNeuroscienceMeth_Zhang.pdf","access_level":"open_access","relation":"main_file","file_size":6924738}],"abstract":[{"lang":"eng","text":"Background: To understand information coding in single neurons, it is necessary to analyze subthreshold synaptic events, action potentials (APs), and their interrelation in different behavioral states. However, detecting excitatory postsynaptic potentials (EPSPs) or currents (EPSCs) in behaving animals remains challenging, because of unfavorable signal-to-noise ratio, high frequency, fluctuating amplitude, and variable time course of synaptic events.\r\nNew method: We developed a method for synaptic event detection, termed MOD (Machine-learning Optimal-filtering Detection-procedure), which combines concepts of supervised machine learning and optimal Wiener filtering. Experts were asked to manually score short epochs of data. The algorithm was trained to obtain the optimal filter coefficients of a Wiener filter and the optimal detection threshold. Scored and unscored data were then processed with the optimal filter, and events were detected as peaks above threshold.\r\nResults: We challenged MOD with EPSP traces in vivo in mice during spatial navigation and EPSC traces in vitro in slices under conditions of enhanced transmitter release. The area under the curve (AUC) of the receiver operating characteristics (ROC) curve was, on average, 0.894 for in vivo and 0.969 for in vitro data sets, indicating high detection accuracy and efficiency.\r\nComparison with existing methods: When benchmarked using a (1 − AUC)−1 metric, MOD outperformed previous methods (template-fit, deconvolution, and Bayesian methods) by an average factor of 3.13 for in vivo data sets, but showed comparable (template-fit, deconvolution) or higher (Bayesian) computational efficacy.\r\nConclusions: MOD may become an important new tool for large-scale, real-time analysis of synaptic activity."}],"publisher":"Elsevier","status":"public","date_created":"2021-04-18T22:01:39Z","author":[{"first_name":"Xiaomin","id":"423EC9C2-F248-11E8-B48F-1D18A9856A87","full_name":"Zhang, Xiaomin","last_name":"Zhang"},{"id":"45BF87EE-F248-11E8-B48F-1D18A9856A87","last_name":"Schlögl","full_name":"Schlögl, Alois","first_name":"Alois","orcid":"0000-0002-5621-8100"},{"first_name":"David H","full_name":"Vandael, David H","id":"3AE48E0A-F248-11E8-B48F-1D18A9856A87","last_name":"Vandael","orcid":"0000-0001-7577-1676"},{"first_name":"Peter M","last_name":"Jonas","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","full_name":"Jonas, Peter M","orcid":"0000-0001-5001-4804"}],"date_updated":"2025-06-12T06:39:15Z","ec_funded":1,"quality_controlled":"1","doi":"10.1016/j.jneumeth.2021.109125","external_id":{"isi":["000661088500005"],"pmid":["33711356"]},"acknowledged_ssus":[{"_id":"SSU"}],"intvolume":"       357","department":[{"_id":"PeJo"},{"_id":"ScienComp"}],"article_number":"109125","year":"2021","_id":"9329","issue":"6","pmid":1,"project":[{"call_identifier":"H2020","_id":"25B7EB9E-B435-11E9-9278-68D0E5697425","name":"Biophysics and circuit function of a giant cortical glutamatergic synapse","grant_number":"692692"},{"grant_number":"Z00312","call_identifier":"FWF","_id":"25C5A090-B435-11E9-9278-68D0E5697425","name":"Synaptic communication in neuronal microcircuits"}],"tmp":{"short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","image":"/images/cc_by_nc_nd.png"},"isi":1,"month":"03","scopus_import":"1","article_type":"original","type":"journal_article","ddc":["570"],"date_published":"2021-03-09T00:00:00Z","publication_status":"published","has_accepted_license":"1","publication":"Journal of Neuroscience Methods","fulldoi":"https://doi.org/10.1016/j.jneumeth.2021.109125","oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"},{"publisher":"National Academy of Sciences","status":"public","date_created":"2021-04-18T22:01:40Z","author":[{"first_name":"Clemens L.","last_name":"Schöpf","full_name":"Schöpf, Clemens L."},{"first_name":"Cornelia","last_name":"Ablinger","full_name":"Ablinger, Cornelia"},{"full_name":"Geisler, Stefanie M.","last_name":"Geisler","first_name":"Stefanie M."},{"full_name":"Stanika, Ruslan I.","last_name":"Stanika","first_name":"Ruslan I."},{"last_name":"Campiglio","full_name":"Campiglio, Marta","first_name":"Marta"},{"first_name":"Walter","id":"3F99E422-F248-11E8-B48F-1D18A9856A87","last_name":"Kaufmann","full_name":"Kaufmann, Walter","orcid":"0000-0001-9735-5315"},{"full_name":"Nimmervoll, Benedikt","last_name":"Nimmervoll","first_name":"Benedikt"},{"first_name":"Bettina","full_name":"Schlick, Bettina","last_name":"Schlick"},{"first_name":"Johannes","full_name":"Brockhaus, Johannes","last_name":"Brockhaus"},{"first_name":"Markus","last_name":"Missler","full_name":"Missler, Markus"},{"orcid":"0000-0001-8761-9444","first_name":"Ryuichi","last_name":"Shigemoto","full_name":"Shigemoto, Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Gerald J.","last_name":"Obermair","full_name":"Obermair, Gerald J."}],"date_updated":"2025-06-12T06:56:21Z","ec_funded":1,"intvolume":"       118","department":[{"_id":"EM-Fac"},{"_id":"RySh"}],"doi":"10.1073/pnas.1920827118","quality_controlled":"1","external_id":{"pmid":["33782113"],"isi":["000637398300002"]},"acknowledged_ssus":[{"_id":"EM-Fac"}],"oa_version":"Published Version","publication_identifier":{"eissn":["1091-6490"]},"day":"06","citation":{"ista":"Schöpf CL, Ablinger C, Geisler SM, Stanika RI, Campiglio M, Kaufmann W, Nimmervoll B, Schlick B, Brockhaus J, Missler M, Shigemoto R, Obermair GJ. 2021. Presynaptic α2δ subunits are key organizers of glutamatergic synapses. Proceedings of the National Academy of Sciences of the United States of America. 118(14).","ama":"Schöpf CL, Ablinger C, Geisler SM, et al. Presynaptic α2δ subunits are key organizers of glutamatergic synapses. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. 2021;118(14). doi:<a href=\"https://doi.org/10.1073/pnas.1920827118\">10.1073/pnas.1920827118</a>","chicago":"Schöpf, Clemens L., Cornelia Ablinger, Stefanie M. Geisler, Ruslan I. Stanika, Marta Campiglio, Walter Kaufmann, Benedikt Nimmervoll, et al. “Presynaptic Α2δ Subunits Are Key Organizers of Glutamatergic Synapses.” <i>Proceedings of the National Academy of Sciences of the United States of America</i>. National Academy of Sciences, 2021. <a href=\"https://doi.org/10.1073/pnas.1920827118\">https://doi.org/10.1073/pnas.1920827118</a>.","ieee":"C. L. Schöpf <i>et al.</i>, “Presynaptic α2δ subunits are key organizers of glutamatergic synapses,” <i>Proceedings of the National Academy of Sciences of the United States of America</i>, vol. 118, no. 14. National Academy of Sciences, 2021.","short":"C.L. Schöpf, C. Ablinger, S.M. Geisler, R.I. Stanika, M. Campiglio, W. Kaufmann, B. Nimmervoll, B. Schlick, J. Brockhaus, M. Missler, R. Shigemoto, G.J. Obermair, Proceedings of the National Academy of Sciences of the United States of America 118 (2021).","mla":"Schöpf, Clemens L., et al. “Presynaptic Α2δ Subunits Are Key Organizers of Glutamatergic Synapses.” <i>Proceedings of the National Academy of Sciences of the United States of America</i>, vol. 118, no. 14, National Academy of Sciences, 2021, doi:<a href=\"https://doi.org/10.1073/pnas.1920827118\">10.1073/pnas.1920827118</a>.","apa":"Schöpf, C. L., Ablinger, C., Geisler, S. M., Stanika, R. I., Campiglio, M., Kaufmann, W., … Obermair, G. J. (2021). Presynaptic α2δ subunits are key organizers of glutamatergic synapses. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.1920827118\">https://doi.org/10.1073/pnas.1920827118</a>"},"volume":118,"language":[{"iso":"eng"}],"file_date_updated":"2021-04-19T10:10:56Z","article_processing_charge":"No","title":"Presynaptic α2δ subunits are key organizers of glutamatergic synapses","abstract":[{"text":"In nerve cells the genes encoding for α2δ subunits of voltage-gated calcium channels have been linked to synaptic functions and neurological disease. Here we show that α2δ subunits are essential for the formation and organization of glutamatergic synapses. Using a cellular α2δ subunit triple-knockout/knockdown model, we demonstrate a failure in presynaptic differentiation evidenced by defective presynaptic calcium channel clustering and calcium influx, smaller presynaptic active zones, and a strongly reduced accumulation of presynaptic vesicle-associated proteins (synapsin and vGLUT). The presynaptic defect is associated with the downscaling of postsynaptic AMPA receptors and the postsynaptic density. The role of α2δ isoforms as synaptic organizers is highly redundant, as each individual α2δ isoform can rescue presynaptic calcium channel trafficking and expression of synaptic proteins. Moreover, α2δ-2 and α2δ-3 with mutated metal ion-dependent adhesion sites can fully rescue presynaptic synapsin expression but only partially calcium channel trafficking, suggesting that the regulatory role of α2δ subunits is independent from its role as a calcium channel subunit. Our findings influence the current view on excitatory synapse formation. First, our study suggests that postsynaptic differentiation is secondary to presynaptic differentiation. Second, the dependence of presynaptic differentiation on α2δ implicates α2δ subunits as potential nucleation points for the organization of synapses. Finally, our results suggest that α2δ subunits act as transsynaptic organizers of glutamatergic synapses, thereby aligning the synaptic active zone with the postsynaptic density.","lang":"eng"}],"file":[{"relation":"main_file","file_size":2603911,"creator":"dernst","date_created":"2021-04-19T10:10:56Z","date_updated":"2021-04-19T10:10:56Z","file_name":"2021_PNAS_Schoepf.pdf","access_level":"open_access","checksum":"dd014f68ae9d7d8d8fc4139a24e04506","file_id":"9340","success":1,"content_type":"application/pdf"}],"acknowledgement":"We thank Arnold Schwartz for providing α2δ-1 knockout mice; Ariane Benedetti, Sabine Baumgartner, Sandra Demetz, and Irene Mahlknecht for technical support; Nadine Ortner and Andreas Lieb for electrophysiological experiments; the team of the Electron Microscopy Facility at the Institute of Science and Technology Austria for technical support related to ultrastructural analysis; Hermann Dietrich and Anja Beierfuß and her team for animal care; Jutta Engel and Jörg Striessnig for critical discussions; and Bruno Benedetti and Bernhard Flucher for critical discussions and reading the manuscript. This study was supported by Austrian Science Fund Grants P24079, F44060, F44150, and DOC30-B30 (to G.J.O.) and T855 (to M.C.), European Research Council Grant AdG 694539 (to R.S.), Deutsche Forschungsgemeinschaft\r\nGrant SFB1348-TP A03 (to M.M.), and Interdisziplinäre Zentrum für Klinische Forschung Münster Grant Mi3/004/19 (to M.M.). This work is part of the PhD theses of C.L.S., S.M.G., and C.A.","date_published":"2021-04-06T00:00:00Z","publication_status":"published","type":"journal_article","ddc":["570"],"publication":"Proceedings of the National Academy of Sciences of the United States of America","has_accepted_license":"1","fulldoi":"https://doi.org/10.1073/pnas.1920827118","oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","year":"2021","issue":"14","pmid":1,"_id":"9330","project":[{"call_identifier":"H2020","_id":"25CA28EA-B435-11E9-9278-68D0E5697425","name":"In situ analysis of single channel subunit composition in neurons: physiological implication in synaptic plasticity and behaviour","grant_number":"694539"}],"tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"article_type":"original","scopus_import":"1","month":"04","isi":1}]