[{"date_created":"2023-12-20T10:48:09Z","scopus_import":"1","quality_controlled":"1","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","citation":{"chicago":"Archer, Lynden A., Peter G. Bruce, Ernesto J. Calvo, Daniel Dewar, James H. J. Ellison, Stefan Alexander Freunberger, Xiangwen Gao, et al. “Towards Practical Metal–Oxygen Batteries: General Discussion.” Faraday Discussions. Royal Society of Chemistry, 2024. https://doi.org/10.1039/d3fd90062b.","apa":"Archer, L. A., Bruce, P. G., Calvo, E. J., Dewar, D., Ellison, J. H. J., Freunberger, S. A., … Ye, S. (2024). Towards practical metal–oxygen batteries: General discussion. Faraday Discussions. Royal Society of Chemistry. https://doi.org/10.1039/d3fd90062b","ieee":"L. A. Archer et al., “Towards practical metal–oxygen batteries: General discussion,” Faraday Discussions, vol. 248. Royal Society of Chemistry, pp. 392–411, 2024.","mla":"Archer, Lynden A., et al. “Towards Practical Metal–Oxygen Batteries: General Discussion.” Faraday Discussions, vol. 248, Royal Society of Chemistry, 2024, pp. 392–411, doi:10.1039/d3fd90062b.","ama":"Archer LA, Bruce PG, Calvo EJ, et al. Towards practical metal–oxygen batteries: General discussion. Faraday Discussions. 2024;248:392-411. doi:10.1039/d3fd90062b","short":"L.A. Archer, P.G. Bruce, E.J. Calvo, D. Dewar, J.H.J. Ellison, S.A. Freunberger, X. Gao, L.J. Hardwick, G. Horwitz, J. Janek, L.R. Johnson, J.W. Jordan, S. Matsuda, S. Menkin, S. Mondal, Q. Qiu, T. Samarakoon, I. Temprano, K. Uosaki, G. Vailaya, E.D. Wachsman, Y. Wu, S. Ye, Faraday Discussions 248 (2024) 392–411.","ista":"Archer LA, Bruce PG, Calvo EJ, Dewar D, Ellison JHJ, Freunberger SA, Gao X, Hardwick LJ, Horwitz G, Janek J, Johnson LR, Jordan JW, Matsuda S, Menkin S, Mondal S, Qiu Q, Samarakoon T, Temprano I, Uosaki K, Vailaya G, Wachsman ED, Wu Y, Ye S. 2024. Towards practical metal–oxygen batteries: General discussion. Faraday Discussions. 248, 392–411."},"status":"public","volume":248,"type":"journal_article","year":"2024","pmid":1,"language":[{"iso":"eng"}],"publication":"Faraday Discussions","title":"Towards practical metal–oxygen batteries: General discussion","intvolume":" 248","page":"392-411","date_published":"2024-01-29T00:00:00Z","isi":1,"department":[{"_id":"StFr"}],"publication_identifier":{"issn":["1359-6640"],"eissn":["1364-5498"]},"external_id":{"pmid":["38112202"],"isi":["001130090400001"]},"_id":"14701","publication_status":"published","publisher":"Royal Society of Chemistry","author":[{"full_name":"Archer, Lynden A.","first_name":"Lynden A.","last_name":"Archer"},{"first_name":"Peter G.","full_name":"Bruce, Peter G.","last_name":"Bruce"},{"last_name":"Calvo","full_name":"Calvo, Ernesto J.","first_name":"Ernesto J."},{"full_name":"Dewar, Daniel","first_name":"Daniel","last_name":"Dewar"},{"full_name":"Ellison, James H. J.","first_name":"James H. J.","last_name":"Ellison"},{"first_name":"Stefan Alexander","orcid":"0000-0003-2902-5319","full_name":"Freunberger, Stefan Alexander","last_name":"Freunberger","id":"A8CA28E6-CE23-11E9-AD2D-EC27E6697425"},{"first_name":"Xiangwen","full_name":"Gao, Xiangwen","last_name":"Gao"},{"first_name":"Laurence J.","full_name":"Hardwick, Laurence J.","last_name":"Hardwick"},{"last_name":"Horwitz","first_name":"Gabriela","full_name":"Horwitz, Gabriela"},{"first_name":"Jürgen","full_name":"Janek, Jürgen","last_name":"Janek"},{"last_name":"Johnson","full_name":"Johnson, Lee R.","first_name":"Lee R."},{"last_name":"Jordan","full_name":"Jordan, Jack W.","first_name":"Jack W."},{"full_name":"Matsuda, Shoichi","first_name":"Shoichi","last_name":"Matsuda"},{"last_name":"Menkin","full_name":"Menkin, Svetlana","first_name":"Svetlana"},{"full_name":"Mondal, Soumyadip","first_name":"Soumyadip","id":"d25d21ef-dc8d-11ea-abe3-ec4576307f48","last_name":"Mondal"},{"first_name":"Qianyuan","full_name":"Qiu, Qianyuan","last_name":"Qiu"},{"last_name":"Samarakoon","full_name":"Samarakoon, Thukshan","first_name":"Thukshan"},{"full_name":"Temprano, Israel","first_name":"Israel","last_name":"Temprano"},{"first_name":"Kohei","full_name":"Uosaki, Kohei","last_name":"Uosaki"},{"full_name":"Vailaya, Ganesh","first_name":"Ganesh","last_name":"Vailaya"},{"first_name":"Eric D.","full_name":"Wachsman, Eric D.","last_name":"Wachsman"},{"last_name":"Wu","first_name":"Yiying","full_name":"Wu, Yiying"},{"full_name":"Ye, Shen","first_name":"Shen","last_name":"Ye"}],"day":"29","doi":"10.1039/d3fd90062b","article_processing_charge":"No","date_updated":"2025-09-04T11:34:30Z","month":"01","article_type":"letter_note","oa_version":"None","keyword":["Physical and Theoretical Chemistry"]},{"oa_version":"None","keyword":["Physical and Theoretical Chemistry"],"article_type":"letter_note","date_updated":"2025-09-04T11:35:09Z","month":"01","doi":"10.1039/d3fd90059b","article_processing_charge":"No","_id":"14702","publication_status":"published","external_id":{"isi":["001130029600001"],"pmid":["38109098"]},"author":[{"last_name":"Attard","first_name":"Gary A.","full_name":"Attard, Gary A."},{"last_name":"Calvo","full_name":"Calvo, Ernesto J.","first_name":"Ernesto J."},{"last_name":"Curtiss","first_name":"Larry A.","full_name":"Curtiss, Larry A."},{"last_name":"Dewar","first_name":"Daniel","full_name":"Dewar, Daniel"},{"first_name":"James H. J.","full_name":"Ellison, James H. J.","last_name":"Ellison"},{"full_name":"Gao, Xiangwen","first_name":"Xiangwen","last_name":"Gao"},{"last_name":"Grey","full_name":"Grey, Clare P.","first_name":"Clare P."},{"last_name":"Hardwick","first_name":"Laurence J.","full_name":"Hardwick, Laurence J."},{"full_name":"Horwitz, Gabriela","first_name":"Gabriela","last_name":"Horwitz"},{"first_name":"Juergen","full_name":"Janek, Juergen","last_name":"Janek"},{"first_name":"Lee R.","full_name":"Johnson, Lee R.","last_name":"Johnson"},{"full_name":"Jordan, Jack W.","first_name":"Jack W.","last_name":"Jordan"},{"last_name":"Matsuda","full_name":"Matsuda, Shoichi","first_name":"Shoichi"},{"first_name":"Soumyadip","full_name":"Mondal, Soumyadip","last_name":"Mondal","id":"d25d21ef-dc8d-11ea-abe3-ec4576307f48"},{"last_name":"Neale","full_name":"Neale, Alex R.","first_name":"Alex R."},{"last_name":"Ortiz-Vitoriano","first_name":"Nagore","full_name":"Ortiz-Vitoriano, Nagore"},{"first_name":"Israel","full_name":"Temprano, Israel","last_name":"Temprano"},{"last_name":"Vailaya","full_name":"Vailaya, Ganesh","first_name":"Ganesh"},{"first_name":"Eric D.","full_name":"Wachsman, Eric D.","last_name":"Wachsman"},{"full_name":"Wang, Hsien-Hau","first_name":"Hsien-Hau","last_name":"Wang"},{"last_name":"Wu","first_name":"Yiying","full_name":"Wu, Yiying"},{"full_name":"Ye, Shen","first_name":"Shen","last_name":"Ye"}],"publisher":"Royal Society of Chemistry","day":"29","isi":1,"publication_identifier":{"eissn":["1364-5498"],"issn":["1359-6640"]},"department":[{"_id":"StFr"}],"page":"75-88","date_published":"2024-01-29T00:00:00Z","intvolume":" 248","language":[{"iso":"eng"}],"publication":"Faraday Discussions","title":"Materials for stable metal–oxygen battery cathodes: general discussion","type":"journal_article","year":"2024","pmid":1,"citation":{"chicago":"Attard, Gary A., Ernesto J. Calvo, Larry A. Curtiss, Daniel Dewar, James H. J. Ellison, Xiangwen Gao, Clare P. Grey, et al. “Materials for Stable Metal–Oxygen Battery Cathodes: General Discussion.” Faraday Discussions. Royal Society of Chemistry, 2024. https://doi.org/10.1039/d3fd90059b.","ieee":"G. A. Attard et al., “Materials for stable metal–oxygen battery cathodes: general discussion,” Faraday Discussions, vol. 248. Royal Society of Chemistry, pp. 75–88, 2024.","apa":"Attard, G. A., Calvo, E. J., Curtiss, L. A., Dewar, D., Ellison, J. H. J., Gao, X., … Ye, S. (2024). Materials for stable metal–oxygen battery cathodes: general discussion. Faraday Discussions. Royal Society of Chemistry. https://doi.org/10.1039/d3fd90059b","ama":"Attard GA, Calvo EJ, Curtiss LA, et al. Materials for stable metal–oxygen battery cathodes: general discussion. Faraday Discussions. 2024;248:75-88. doi:10.1039/d3fd90059b","mla":"Attard, Gary A., et al. “Materials for Stable Metal–Oxygen Battery Cathodes: General Discussion.” Faraday Discussions, vol. 248, Royal Society of Chemistry, 2024, pp. 75–88, doi:10.1039/d3fd90059b.","short":"G.A. Attard, E.J. Calvo, L.A. Curtiss, D. Dewar, J.H.J. Ellison, X. Gao, C.P. Grey, L.J. Hardwick, G. Horwitz, J. Janek, L.R. Johnson, J.W. Jordan, S. Matsuda, S. Mondal, A.R. Neale, N. Ortiz-Vitoriano, I. Temprano, G. Vailaya, E.D. Wachsman, H.-H. Wang, Y. Wu, S. Ye, Faraday Discussions 248 (2024) 75–88.","ista":"Attard GA, Calvo EJ, Curtiss LA, Dewar D, Ellison JHJ, Gao X, Grey CP, Hardwick LJ, Horwitz G, Janek J, Johnson LR, Jordan JW, Matsuda S, Mondal S, Neale AR, Ortiz-Vitoriano N, Temprano I, Vailaya G, Wachsman ED, Wang H-H, Wu Y, Ye S. 2024. Materials for stable metal–oxygen battery cathodes: general discussion. Faraday Discussions. 248, 75–88."},"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","status":"public","volume":248,"date_created":"2023-12-20T10:49:43Z","scopus_import":"1","quality_controlled":"1"},{"doi":"10.1007/s10208-024-09686-3","abstract":[{"lang":"eng","text":"We present a discretization of the dynamic optimal transport problem for which we can obtain the convergence rate for the value of the transport cost to its continuous value when the temporal and spatial stepsize vanish. This convergence result does not require any regularity assumption on the measures, though experiments suggest that the rate is not sharp. Via an analysis of the duality gap we also obtain the convergence rates for the gradient of the optimal potentials and the velocity field under mild regularity assumptions. To obtain such rates we discretize the dual formulation of the dynamic optimal transport problem and use the mature literature related to the error due to discretizing the Hamilton-Jacobi equation."}],"article_processing_charge":"Yes (via OA deal)","author":[{"id":"6F7C4B96-A8E9-11E9-A7CA-09ECE5697425","last_name":"Ishida","full_name":"Ishida, Sadashige","orcid":"0000-0002-3121-3100","first_name":"Sadashige"},{"first_name":"Hugo","full_name":"Lavenant, Hugo","last_name":"Lavenant"}],"_id":"14703","external_id":{"isi":["001352503300001"],"arxiv":["2312.12213"]},"publisher":"Springer Nature","publication_status":"epub_ahead","project":[{"grant_number":"101045083","name":"Computational Discovery of Numerical Algorithms for Animation and Simulation of Natural Phenomena","_id":"34bc2376-11ca-11ed-8bc3-9a3b3961a088"}],"day":"11","ddc":["000"],"OA_type":"hybrid","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1007/s10208-024-09686-3"}],"acknowledgement":"The authors would like to thank Chris Wojtan for his continuous support and several interesting discussions. Part of this research was performed during two visits: one of SI to the BIDSA research center at Bocconi University, and one of HL to the Institute of Science and Technology Austria. Both host institutions are warmly acknowledged for the hospitality. HL is partially supported by the MUR-Prin 2022-202244A7YL “Gradient Flows and Non-Smooth Geometric Structures with Applications to Optimization and Machine Learning”, funded by the European Union - Next Generation EU. SI is supported in part by ERC Consolidator Grant 101045083 “CoDiNA” funded by the European Research Council.","date_updated":"2026-06-18T17:37:10Z","month":"11","keyword":["Optimal transport","Hamilton-Jacobi equation","convex optimization"],"oa_version":"Published Version","oa":1,"article_type":"original","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"mla":"Ishida, Sadashige, and Hugo Lavenant. “Quantitative Convergence of a Discretization of Dynamic Optimal Transport Using the Dual Formulation.” Foundations of Computational Mathematics, Springer Nature, 2024, doi:10.1007/s10208-024-09686-3.","ama":"Ishida S, Lavenant H. Quantitative convergence of a discretization of dynamic optimal transport using the dual formulation. Foundations of Computational Mathematics. 2024. doi:10.1007/s10208-024-09686-3","short":"S. Ishida, H. Lavenant, Foundations of Computational Mathematics (2024).","ista":"Ishida S, Lavenant H. 2024. Quantitative convergence of a discretization of dynamic optimal transport using the dual formulation. Foundations of Computational Mathematics.","chicago":"Ishida, Sadashige, and Hugo Lavenant. “Quantitative Convergence of a Discretization of Dynamic Optimal Transport Using the Dual Formulation.” Foundations of Computational Mathematics. Springer Nature, 2024. https://doi.org/10.1007/s10208-024-09686-3.","apa":"Ishida, S., & Lavenant, H. (2024). Quantitative convergence of a discretization of dynamic optimal transport using the dual formulation. Foundations of Computational Mathematics. Springer Nature. https://doi.org/10.1007/s10208-024-09686-3","ieee":"S. Ishida and H. Lavenant, “Quantitative convergence of a discretization of dynamic optimal transport using the dual formulation,” Foundations of Computational Mathematics. Springer Nature, 2024."},"status":"public","date_created":"2023-12-21T10:14:37Z","quality_controlled":"1","scopus_import":"1","language":[{"iso":"eng"}],"corr_author":"1","publication":"Foundations of Computational Mathematics","title":"Quantitative convergence of a discretization of dynamic optimal transport using the dual formulation","type":"journal_article","year":"2024","arxiv":1,"date_published":"2024-11-11T00:00:00Z","OA_place":"publisher","isi":1,"publication_identifier":{"eissn":["1615-3383"],"issn":["1615-3375"]},"department":[{"_id":"GradSch"},{"_id":"ChWo"}]},{"file":[{"relation":"main_file","file_size":847,"checksum":"bdaf1392867786634ec5466d528c36ca","file_name":"readme.txt.txt","date_updated":"2023-12-22T13:54:21Z","date_created":"2023-12-22T13:54:21Z","content_type":"text/plain","file_id":"14707","access_level":"open_access","success":1,"creator":"melkrewi"},{"creator":"melkrewi","success":1,"access_level":"open_access","file_id":"14708","content_type":"application/x-zip-compressed","date_updated":"2023-12-22T14:14:06Z","date_created":"2023-12-22T14:14:06Z","checksum":"973e1cbdab923a71709782177980829f","file_name":"data_artemia_franciscana_genome.zip","file_size":343632753,"relation":"main_file"}],"title":"Data from \"Chromosome-level assembly of Artemia franciscana sheds light on sex-chromosome differentiation\"","corr_author":"1","year":"2024","ddc":["576"],"type":"research_data","citation":{"chicago":"Elkrewi, Marwan N. “Data from ‘Chromosome-Level Assembly of Artemia Franciscana Sheds Light on Sex-Chromosome Differentiation.’” Institute of Science and Technology Austria, 2024. https://doi.org/10.15479/AT:ISTA:14705.","ieee":"M. N. Elkrewi, “Data from ‘Chromosome-level assembly of Artemia franciscana sheds light on sex-chromosome differentiation.’” Institute of Science and Technology Austria, 2024.","apa":"Elkrewi, M. N. (2024). Data from “Chromosome-level assembly of Artemia franciscana sheds light on sex-chromosome differentiation.” Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:14705","ama":"Elkrewi MN. Data from “Chromosome-level assembly of Artemia franciscana sheds light on sex-chromosome differentiation.” 2024. doi:10.15479/AT:ISTA:14705","mla":"Elkrewi, Marwan N. Data from “Chromosome-Level Assembly of Artemia Franciscana Sheds Light on Sex-Chromosome Differentiation.” Institute of Science and Technology Austria, 2024, doi:10.15479/AT:ISTA:14705.","short":"M.N. Elkrewi, (2024).","ista":"Elkrewi MN. 2024. Data from ‘Chromosome-level assembly of Artemia franciscana sheds light on sex-chromosome differentiation’, Institute of Science and Technology Austria, 10.15479/AT:ISTA:14705."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_processing_charge":"No","abstract":[{"lang":"eng","text":"Since the commercialization of brine shrimp (genus Artemia) in the 1950s, this lineage, and in particular the model species Artemia franciscana, has been the subject of extensive research. However, our understanding of the genetic mechanisms underlying various aspects of their reproductive biology, including sex determination, are still lacking. This is partly due to the scarcity of genomic resources for Artemia species and crustaceans in general. Here, we present a chromosome-level genome assembly of Artemia franciscana (Kellogg 1906), from the Great Salt Lake, USA. The genome is 1GB, and the majority of the genome (81%) is scaffolded into 21 linkage groups using a previously published high-density linkage map. We performed coverage and FST analyses using male and female genomic and transcriptomic reads to quantify the extent of differentiation between the Z and W chromosomes. Additionally, we quantified the expression levels in male and female heads and gonads and found further evidence for dosage compensation in this species."}],"doi":"10.15479/AT:ISTA:14705","status":"public","publisher":"Institute of Science and Technology Austria","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"_id":"14705","date_created":"2023-12-22T13:40:48Z","author":[{"id":"0B46FACA-A8E1-11E9-9BD3-79D1E5697425","last_name":"Elkrewi","first_name":"Marwan N","full_name":"Elkrewi, Marwan N","orcid":"0000-0002-5328-7231"}],"day":"02","related_material":{"record":[{"status":"public","id":"15009","relation":"used_in_publication"}]},"project":[{"grant_number":"F8810","_id":"34ae1506-11ca-11ed-8bc3-c14f4c474396","name":"The highjacking of meiosis for asexual reproduction"}],"keyword":["sex chromosome evolution","genome assembly","dosage compensation"],"contributor":[{"contributor_type":"researcher","first_name":"Vincent K","id":"57854184-AAE0-11E9-8D04-98D6E5697425","last_name":"Bett"},{"last_name":"Macon","id":"2A0848E2-F248-11E8-B48F-1D18A9856A87","contributor_type":"project_member","first_name":"Ariana"},{"last_name":"Vicoso","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4579-8306","contributor_type":"supervisor","first_name":"Beatriz"},{"id":"0B46FACA-A8E1-11E9-9BD3-79D1E5697425","last_name":"Elkrewi","orcid":"0000-0002-5328-7231","contributor_type":"researcher","first_name":"Marwan N"}],"file_date_updated":"2023-12-22T14:14:06Z","oa_version":"Published Version","department":[{"_id":"GradSch"},{"_id":"BeVi"}],"oa":1,"date_published":"2024-01-02T00:00:00Z","date_updated":"2025-09-04T12:05:42Z","has_accepted_license":"1","month":"01"},{"day":"19","project":[{"grant_number":"665385","call_identifier":"H2020","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","name":"International IST Doctoral Program"},{"grant_number":"P32896","name":"Causes and consequences of population fragmentation","_id":"c08d3278-5a5b-11eb-8a69-fdb09b55f4b8"},{"grant_number":"26380","_id":"34c872fe-11ca-11ed-8bc3-8534b82131e6","name":"Polygenic Adaptation in a Metapopulation"}],"author":[{"last_name":"Olusanya","id":"41AD96DC-F248-11E8-B48F-1D18A9856A87","first_name":"Oluwafunmilola O","orcid":"0000-0003-1971-8314","full_name":"Olusanya, Oluwafunmilola O"}],"_id":"14711","publisher":"Institute of Science and Technology Austria","publication_status":"published","article_processing_charge":"No","abstract":[{"text":"In nature, different species find their niche in a range of environments, each with its unique characteristics. While some thrive in uniform (homogeneous) landscapes where environmental conditions stay relatively consistent across space, others traverse the complexities of spatially heterogeneous terrains. Comprehending how species are distributed and how they interact within these landscapes holds the key to gaining insights into their evolutionary dynamics while also informing conservation and management strategies.\r\n\r\nFor species inhabiting heterogeneous landscapes, when the rate of dispersal is low compared to spatial fluctuations in selection pressure, localized adaptations may emerge. Such adaptation in response to varying selection strengths plays an important role in the persistence of populations in our rapidly changing world. Hence, species in nature are continuously in a struggle to adapt to local environmental conditions, to ensure their continued survival. Natural populations can often adapt in time scales short enough for evolutionary changes to influence ecological dynamics and vice versa, thereby creating a feedback between evolution and demography. The analysis of this feedback and the relative contributions of gene flow, demography, drift, and natural selection to genetic variation and differentiation has remained a recurring theme in evolutionary biology. Nevertheless, the effective role of these forces in maintaining variation and shaping patterns of diversity is not fully understood. Even in homogeneous environments devoid of local adaptations, such understanding remains elusive. Understanding this feedback is crucial, for example in determining the conditions under which extinction risk can be mitigated in peripheral populations subject to deleterious mutation accumulation at the edges of species’ ranges\r\nas well as in highly fragmented populations.\r\n\r\nIn this thesis we explore both uniform and spatially heterogeneous metapopulations, investigating and providing theoretical insights into the dynamics of local adaptation in the latter and examining the dynamics of load and extinction as well as the impact of joint ecological and evolutionary (eco-evolutionary) dynamics in the former. The thesis is divided into 5 chapters.\r\n\r\nChapter 1 provides a general introduction into the subject matter, clarifying concepts and ideas used throughout the thesis. In chapter 2, we explore how fast a species distributed across a heterogeneous landscape adapts to changing conditions marked by alterations in carrying capacity, selection pressure, and migration rate.\r\n\r\nIn chapter 3, we investigate how migration selection and drift influences adaptation and the maintenance of variation in a metapopulation with three habitats, an extension of previous models of adaptation in two habitats. We further develop analytical approximations for the critical threshold required for polymorphism to persist.\r\n\r\nThe focus of chapter 4 of the thesis is on understanding the interplay between ecology and evolution as coupled processes. We investigate how eco-evolutionary feedback between migration, selection, drift, and demography influences eco-evolutionary outcomes in marginal populations subject to deleterious mutation accumulation. Using simulations as well as theoretical approximations of the coupled dynamics of population size and allele frequency, we analyze how gene flow from a large mainland source influences genetic load and population size on an island (i.e., in a marginal population) under genetically realistic assumptions. Analyses of this sort are important because small isolated populations, are repeatedly affected by complex interactions between ecological and evolutionary processes, which can lead to their death. Understanding these interactions can therefore provide an insight into the conditions under which extinction risk can be mitigated in peripheral populations thus, contributing to conservation and restoration efforts.\r\n\r\nChapter 5 extends the analysis in chapter 4 to consider the dynamics of load (due to deleterious mutation accumulation) and extinction risk in a metapopulation. We explore the role of gene flow, selection, and dominance on load and extinction risk and further pinpoint critical thresholds required for metapopulation persistence.\r\n\r\nOverall this research contributes to our understanding of ecological and evolutionary mechanisms that shape species’ persistence in fragmented landscapes, a crucial foundation for successful conservation efforts and biodiversity management.","lang":"eng"}],"doi":"10.15479/at:ista:14711","ddc":["576"],"ec_funded":1,"month":"01","date_updated":"2026-04-07T12:54:29Z","has_accepted_license":"1","oa":1,"file_date_updated":"2024-01-03T18:31:34Z","oa_version":"Published Version","degree_awarded":"PhD","related_material":{"record":[{"status":"public","id":"10787","relation":"part_of_dissertation"},{"id":"10658","status":"public","relation":"part_of_dissertation"},{"relation":"part_of_dissertation","id":"14732","status":"public"}]},"tmp":{"name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)","image":"/images/cc_by_nc_sa.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode","short":"CC BY-NC-SA (4.0)"},"date_created":"2023-12-26T22:49:53Z","status":"public","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","citation":{"ieee":"O. O. Olusanya, “Local adaptation, genetic load and extinction in metapopulations,” Institute of Science and Technology Austria, 2024.","apa":"Olusanya, O. O. (2024). Local adaptation, genetic load and extinction in metapopulations. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:14711","chicago":"Olusanya, Oluwafunmilola O. “Local Adaptation, Genetic Load and Extinction in Metapopulations.” Institute of Science and Technology Austria, 2024. https://doi.org/10.15479/at:ista:14711.","short":"O.O. Olusanya, Local Adaptation, Genetic Load and Extinction in Metapopulations, Institute of Science and Technology Austria, 2024.","ista":"Olusanya OO. 2024. Local adaptation, genetic load and extinction in metapopulations. Institute of Science and Technology Austria.","ama":"Olusanya OO. Local adaptation, genetic load and extinction in metapopulations. 2024. doi:10.15479/at:ista:14711","mla":"Olusanya, Oluwafunmilola O. Local Adaptation, Genetic Load and Extinction in Metapopulations. Institute of Science and Technology Austria, 2024, doi:10.15479/at:ista:14711."},"type":"dissertation","year":"2024","title":"Local adaptation, genetic load and extinction in metapopulations","corr_author":"1","language":[{"iso":"eng"}],"file":[{"relation":"source_file","file_size":16986244,"checksum":"de179b1c6758f182ff0c70d8b38c1501","file_name":"FinalSubmission_Thesis_OLUSANYA.zip","date_updated":"2024-01-03T18:30:13Z","date_created":"2024-01-03T18:30:13Z","content_type":"application/zip","file_id":"14730","access_level":"closed","creator":"oolusany"},{"relation":"main_file","file_size":6460403,"file_name":"FinalSubmission2_Thesis_OLUSANYA.pdf","checksum":"0e331585e3cd4823320aab4e69e64ccf","date_created":"2024-01-03T18:31:34Z","date_updated":"2024-01-03T18:31:34Z","content_type":"application/pdf","access_level":"open_access","file_id":"14731","success":1,"creator":"oolusany"}],"date_published":"2024-01-19T00:00:00Z","alternative_title":["ISTA Thesis"],"page":"183","supervisor":[{"first_name":"Nicholas H","orcid":"0000-0002-8548-5240","full_name":"Barton, Nicholas H","last_name":"Barton","id":"4880FE40-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Jitka","full_name":"Polechova, Jitka","last_name":"Polechova"},{"last_name":"Sachdeva","full_name":"Sachdeva, Himani","first_name":"Himani"}],"department":[{"_id":"NiBa"},{"_id":"GradSch"}],"publication_identifier":{"issn":["2663-337X"]},"acknowledged_ssus":[{"_id":"SSU"}],"license":"https://creativecommons.org/licenses/by-nc-sa/4.0/","OA_place":"publisher"},{"issue":"5","year":"2024","type":"journal_article","pmid":1,"language":[{"iso":"eng"}],"publication":"The Plant Cell","title":"The RALF signaling pathway regulates cell wall integrity during pollen tube growth in maize","date_created":"2024-01-02T11:19:37Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","short":"CC BY-NC-ND (4.0)","image":"/images/cc_by_nc_nd.png","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)"},"quality_controlled":"1","scopus_import":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"ieee":"L.-Z. Zhou et al., “The RALF signaling pathway regulates cell wall integrity during pollen tube growth in maize,” The Plant Cell, vol. 36, no. 5. Oxford University Press, 2024.","apa":"Zhou, L.-Z., Wang, L., Chen, X., Ge, Z., Mergner, J., Li, X., … Dresselhaus, T. (2024). The RALF signaling pathway regulates cell wall integrity during pollen tube growth in maize. The Plant Cell. Oxford University Press. https://doi.org/10.1093/plcell/koad324","chicago":"Zhou, Liang-Zi, Lele Wang, Xia Chen, Zengxiang Ge, Julia Mergner, Xingli Li, Bernhard Küster, Gernot Längst, Li-Jia Qu, and Thomas Dresselhaus. “The RALF Signaling Pathway Regulates Cell Wall Integrity during Pollen Tube Growth in Maize.” The Plant Cell. Oxford University Press, 2024. https://doi.org/10.1093/plcell/koad324.","short":"L.-Z. Zhou, L. Wang, X. Chen, Z. Ge, J. Mergner, X. Li, B. Küster, G. Längst, L.-J. Qu, T. Dresselhaus, The Plant Cell 36 (2024).","ista":"Zhou L-Z, Wang L, Chen X, Ge Z, Mergner J, Li X, Küster B, Längst G, Qu L-J, Dresselhaus T. 2024. The RALF signaling pathway regulates cell wall integrity during pollen tube growth in maize. The Plant Cell. 36(5), koad324.","ama":"Zhou L-Z, Wang L, Chen X, et al. The RALF signaling pathway regulates cell wall integrity during pollen tube growth in maize. The Plant Cell. 2024;36(5). doi:10.1093/plcell/koad324","mla":"Zhou, Liang-Zi, et al. “The RALF Signaling Pathway Regulates Cell Wall Integrity during Pollen Tube Growth in Maize.” The Plant Cell, vol. 36, no. 5, koad324, Oxford University Press, 2024, doi:10.1093/plcell/koad324."},"status":"public","volume":36,"publication_identifier":{"issn":["1040-4651"],"eissn":["1532-298X"]},"intvolume":" 36","date_published":"2024-05-01T00:00:00Z","article_number":"koad324","ddc":["580"],"author":[{"last_name":"Zhou","first_name":"Liang-Zi","full_name":"Zhou, Liang-Zi"},{"first_name":"Lele","full_name":"Wang, Lele","last_name":"Wang"},{"last_name":"Chen","first_name":"Xia","full_name":"Chen, Xia"},{"first_name":"Zengxiang","orcid":"0000-0001-9381-3577","full_name":"Ge, Zengxiang","last_name":"Ge","id":"f43371a3-09ff-11eb-8013-bd0c6a2f6de8"},{"first_name":"Julia","full_name":"Mergner, Julia","last_name":"Mergner"},{"last_name":"Li","full_name":"Li, Xingli","first_name":"Xingli"},{"last_name":"Küster","first_name":"Bernhard","full_name":"Küster, Bernhard"},{"last_name":"Längst","first_name":"Gernot","full_name":"Längst, Gernot"},{"last_name":"Qu","full_name":"Qu, Li-Jia","first_name":"Li-Jia"},{"first_name":"Thomas","full_name":"Dresselhaus, Thomas","last_name":"Dresselhaus"}],"_id":"14726","external_id":{"pmid":["38142229"]},"publication_status":"published","publisher":"Oxford University Press","extern":"1","day":"01","doi":"10.1093/plcell/koad324","article_processing_charge":"No","abstract":[{"lang":"eng","text":"Autocrine signaling pathways regulated by RAPID ALKALINIZATION FACTORs (RALFs) control cell wall integrity during pollen tube germination and growth in Arabidopsis (Arabidopsis thaliana). To investigate the role of pollen-specific RALFs in another plant species, we combined gene expression data with phylogenetic and biochemical studies to identify candidate orthologs in maize (Zea mays). We show that Clade IB ZmRALF2/3 mutations, but not Clade III ZmRALF1/5 mutations, cause cell wall instability in the sub-apical region of the growing pollen tube. ZmRALF2/3 are mainly located in the cell wall and are partially able to complement the pollen germination defect of their Arabidopsis orthologs AtRALF4/19. Mutations in ZmRALF2/3 compromise pectin distribution patterns leading to altered cell wall organization and thickness culminating in pollen tube burst. Clade IB, but not Clade III ZmRALFs, strongly interact as ligands with the pollen-specific Catharanthus roseus RLK1-like (CrRLK1L) receptor kinases Zea mays FERONIA-like (ZmFERL) 4/7/9, LORELEI-like glycosylphosphatidylinositol-anchor (LLG) proteins Zea mays LLG 1 and 2 (ZmLLG1/2) and Zea mays pollen extension-like (PEX) cell wall proteins ZmPEX2/4. Notably, ZmFERL4 outcompetes ZmLLG2 and ZmPEX2 outcompetes ZmFERL4 for ZmRALF2 binding. Based on these data, we suggest that Clade IB RALFs act in a dual role as cell wall components and extracellular sensors to regulate cell wall integrity and thickness during pollen tube growth in maize and probably other plants."}],"oa":1,"article_type":"original","oa_version":"Published Version","keyword":["Cell Biology","Plant Science"],"has_accepted_license":"1","date_updated":"2024-07-16T11:18:46Z","month":"05","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1093/plcell/koad324"}]},{"ddc":["540"],"ec_funded":1,"_id":"14733","author":[{"orcid":"0000-0002-0404-4356","full_name":"Jethwa, Rajesh B","first_name":"Rajesh B","last_name":"Jethwa","id":"4cc538d5-803f-11ed-ab7e-8139573aad8f"},{"last_name":"Hey","full_name":"Hey, Dominic","first_name":"Dominic"},{"full_name":"Kerber, Rachel N.","first_name":"Rachel N.","last_name":"Kerber"},{"last_name":"Bond","full_name":"Bond, Andrew D.","first_name":"Andrew D."},{"first_name":"Dominic S.","full_name":"Wright, Dominic S.","last_name":"Wright"},{"last_name":"Grey","first_name":"Clare P.","full_name":"Grey, Clare P."}],"publisher":"American Chemical Society","external_id":{"isi":["001146733200001"],"pmid":["38273966"]},"publication_status":"published","project":[{"_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","name":"IST-BRIDGE: International postdoctoral program","grant_number":"101034413","call_identifier":"H2020"}],"day":"22","doi":"10.1021/acsaem.3c02223","abstract":[{"lang":"eng","text":"Redox flow batteries (RFBs) rely on the development of cheap, highly soluble, and high-energy-density electrolytes. Several candidate quinones have already been investigated in the literature as two-electron anolytes or catholytes, benefiting from fast kinetics, high tunability, and low cost. Here, an investigation of nitrogen-rich fused heteroaromatic quinones was carried out to explore avenues for electrolyte development. These quinones were synthesized and screened by using electrochemical techniques. The most promising candidate, 4,8-dioxo-4,8-dihydrobenzo[1,2-d:4,5-d′]bis([1,2,3]triazole)-1,5-diide (−0.68 V(SHE)), was tested in both an asymmetric and symmetric full-cell setup resulting in capacity fade rates of 0.35% per cycle and 0.0124% per cycle, respectively. In situ ultraviolet-visible spectroscopy (UV–Vis), nuclear magnetic resonance (NMR), and electron paramagnetic resonance (EPR) spectroscopies were used to investigate the electrochemical stability of the charged species during operation. UV–Vis spectroscopy, supported by density functional theory (DFT) modeling, reaffirmed that the two-step charging mechanism observed during battery operation consisted of two, single-electron transfers. The radical concentration during battery operation and the degree of delocalization of the unpaired electron were quantified with NMR and EPR spectroscopy."}],"article_processing_charge":"Yes (in subscription journal)","oa":1,"article_type":"original","oa_version":"Published Version","file_date_updated":"2024-07-16T11:59:24Z","keyword":["Electrical and Electronic Engineering","Materials Chemistry","Electrochemistry","Energy Engineering and Power Technology","Chemical Engineering (miscellaneous)"],"has_accepted_license":"1","date_updated":"2025-09-04T11:36:32Z","month":"01","main_file_link":[{"url":"https://doi.org/10.1021/acsaem.3c02223","open_access":"1"}],"type":"journal_article","issue":"2","year":"2024","pmid":1,"file":[{"checksum":"2841e86a041d249ac0df2531b7f9aec1","file_name":"2024_ACSAppElecMaterials_Jethwa.pdf","relation":"main_file","file_size":5607177,"content_type":"application/pdf","date_updated":"2024-07-16T11:59:24Z","date_created":"2024-07-16T11:59:24Z","success":1,"file_id":"17262","access_level":"open_access","creator":"dernst"}],"language":[{"iso":"eng"}],"publication":"ACS Applied Energy Materials","title":"Exploring the landscape of heterocyclic quinones for redox flow batteries","date_created":"2024-01-05T09:20:48Z","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"quality_controlled":"1","scopus_import":"1","citation":{"ieee":"R. B. Jethwa, D. Hey, R. N. Kerber, A. D. Bond, D. S. Wright, and C. P. Grey, “Exploring the landscape of heterocyclic quinones for redox flow batteries,” ACS Applied Energy Materials, vol. 7, no. 2. American Chemical Society, pp. 414–426, 2024.","apa":"Jethwa, R. B., Hey, D., Kerber, R. N., Bond, A. D., Wright, D. S., & Grey, C. P. (2024). Exploring the landscape of heterocyclic quinones for redox flow batteries. ACS Applied Energy Materials. American Chemical Society. https://doi.org/10.1021/acsaem.3c02223","chicago":"Jethwa, Rajesh B, Dominic Hey, Rachel N. Kerber, Andrew D. Bond, Dominic S. Wright, and Clare P. Grey. “Exploring the Landscape of Heterocyclic Quinones for Redox Flow Batteries.” ACS Applied Energy Materials. American Chemical Society, 2024. https://doi.org/10.1021/acsaem.3c02223.","short":"R.B. Jethwa, D. Hey, R.N. Kerber, A.D. Bond, D.S. Wright, C.P. Grey, ACS Applied Energy Materials 7 (2024) 414–426.","ista":"Jethwa RB, Hey D, Kerber RN, Bond AD, Wright DS, Grey CP. 2024. Exploring the landscape of heterocyclic quinones for redox flow batteries. ACS Applied Energy Materials. 7(2), 414–426.","ama":"Jethwa RB, Hey D, Kerber RN, Bond AD, Wright DS, Grey CP. Exploring the landscape of heterocyclic quinones for redox flow batteries. ACS Applied Energy Materials. 2024;7(2):414-426. doi:10.1021/acsaem.3c02223","mla":"Jethwa, Rajesh B., et al. “Exploring the Landscape of Heterocyclic Quinones for Redox Flow Batteries.” ACS Applied Energy Materials, vol. 7, no. 2, American Chemical Society, 2024, pp. 414–26, doi:10.1021/acsaem.3c02223."},"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","status":"public","volume":7,"isi":1,"department":[{"_id":"StFr"}],"publication_identifier":{"eissn":["2574-0962"]},"intvolume":" 7","page":"414-426","date_published":"2024-01-22T00:00:00Z"},{"date_created":"2024-01-07T23:00:51Z","quality_controlled":"1","scopus_import":"1","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","citation":{"short":"S. Wan, S. Xiao, M. Li, X. Wang, K.H. Lim, M. Hong, M. Ibáñez, A. Cabot, Y. Liu, Small Methods 8 (2024).","ista":"Wan S, Xiao S, Li M, Wang X, Lim KH, Hong M, Ibáñez M, Cabot A, Liu Y. 2024. Band engineering through Pb-doping of nanocrystal building blocks to enhance thermoelectric performance in Cu3SbSe4. Small Methods. 8(8), 2301377.","ama":"Wan S, Xiao S, Li M, et al. Band engineering through Pb-doping of nanocrystal building blocks to enhance thermoelectric performance in Cu3SbSe4. Small Methods. 2024;8(8). doi:10.1002/smtd.202301377","mla":"Wan, Shanhong, et al. “Band Engineering through Pb-Doping of Nanocrystal Building Blocks to Enhance Thermoelectric Performance in Cu3SbSe4.” Small Methods, vol. 8, no. 8, 2301377, Wiley, 2024, doi:10.1002/smtd.202301377.","ieee":"S. Wan et al., “Band engineering through Pb-doping of nanocrystal building blocks to enhance thermoelectric performance in Cu3SbSe4,” Small Methods, vol. 8, no. 8. Wiley, 2024.","apa":"Wan, S., Xiao, S., Li, M., Wang, X., Lim, K. H., Hong, M., … Liu, Y. (2024). Band engineering through Pb-doping of nanocrystal building blocks to enhance thermoelectric performance in Cu3SbSe4. Small Methods. Wiley. https://doi.org/10.1002/smtd.202301377","chicago":"Wan, Shanhong, Shanshan Xiao, Mingquan Li, Xin Wang, Khak Ho Lim, Min Hong, Maria Ibáñez, Andreu Cabot, and Yu Liu. “Band Engineering through Pb-Doping of Nanocrystal Building Blocks to Enhance Thermoelectric Performance in Cu3SbSe4.” Small Methods. Wiley, 2024. https://doi.org/10.1002/smtd.202301377."},"volume":8,"status":"public","year":"2024","issue":"8","type":"journal_article","pmid":1,"language":[{"iso":"eng"}],"title":"Band engineering through Pb-doping of nanocrystal building blocks to enhance thermoelectric performance in Cu3SbSe4","publication":"Small Methods","intvolume":" 8","article_number":"2301377","date_published":"2024-08-01T00:00:00Z","publication_identifier":{"eissn":["2366-9608"]},"department":[{"_id":"MaIb"}],"isi":1,"_id":"14734","external_id":{"isi":["001133369800001"],"pmid":["38152986"]},"publication_status":"published","author":[{"full_name":"Wan, Shanhong","first_name":"Shanhong","last_name":"Wan"},{"last_name":"Xiao","full_name":"Xiao, Shanshan","first_name":"Shanshan"},{"last_name":"Li","first_name":"Mingquan","full_name":"Li, Mingquan"},{"first_name":"Xin","full_name":"Wang, Xin","last_name":"Wang"},{"last_name":"Lim","first_name":"Khak Ho","full_name":"Lim, Khak Ho"},{"first_name":"Min","full_name":"Hong, Min","last_name":"Hong"},{"last_name":"Ibáñez","id":"43C61214-F248-11E8-B48F-1D18A9856A87","first_name":"Maria","orcid":"0000-0001-5013-2843","full_name":"Ibáñez, Maria"},{"full_name":"Cabot, Andreu","first_name":"Andreu","last_name":"Cabot"},{"first_name":"Yu","orcid":"0000-0001-7313-6740","full_name":"Liu, Yu","last_name":"Liu","id":"2A70014E-F248-11E8-B48F-1D18A9856A87"}],"publisher":"Wiley","day":"01","project":[{"_id":"9B8F7476-BA93-11EA-9121-9846C619BF3A","name":"HighTE: The Werner Siemens Laboratory for the High Throughput Discovery of Semiconductors for Waste Heat Recovery"}],"abstract":[{"text":"Developing cost-effective and high-performance thermoelectric (TE) materials to assemble efficient TE devices presents a multitude of challenges and opportunities. Cu3SbSe4 is a promising p-type TE material based on relatively earth abundant elements. However, the challenge lies in its poor electrical conductivity. Herein, an efficient and scalable solution-based approach is developed to synthesize high-quality Cu3SbSe4 nanocrystals doped with Pb at the Sb site. After ligand displacement and annealing treatments, the dried powders are consolidated into dense pellets, and their TE properties are investigated. Pb doping effectively increases the charge carrier concentration, resulting in a significant increase in electrical conductivity, while the Seebeck coefficients remain consistently high. The calculated band structure shows that Pb doping induces band convergence, thereby increasing the effective mass. Furthermore, the large ionic radius of Pb2+ results in the generation of additional point and plane defects and interphases, dramatically enhancing phonon scattering, which significantly decreases the lattice thermal conductivity at high temperatures. Overall, a maximum figure of merit (zTmax) ≈ 0.85 at 653 K is obtained in Cu3Sb0.97Pb0.03Se4. This represents a 1.6-fold increase compared to the undoped sample and exceeds most doped Cu3SbSe4-based materials produced by solid-state, demonstrating advantages of versatility and cost-effectiveness using a solution-based technology.","lang":"eng"}],"article_processing_charge":"No","doi":"10.1002/smtd.202301377","date_updated":"2025-09-04T11:37:19Z","month":"08","OA_type":"closed access","acknowledgement":"Y.L. acknowledges funding from the National Natural Science Foundation of China (NSFC) (Grants No. 22209034), the Innovation and Entrepreneurship Project of Overseas Returnees in Anhui Province (Grant No. 2022LCX002). K.H.L. acknowledges financial support from the National Natural Science Foundation of China (NSFC) (Grant No. 22208293). M.I. acknowledges financial support from ISTA and the Werner Siemens Foundation.","article_type":"original","oa_version":"None"},{"publication":"2024 Proceedings of the Symposium on Algorithm Engineering and Experiments","corr_author":"1","title":"Experimental evaluation of fully dynamic k-means via coresets","language":[{"iso":"eng"}],"year":"2024","type":"conference","status":"public","citation":{"ieee":"M. Henzinger, D. Saulpic, and L. Sidl, “Experimental evaluation of fully dynamic k-means via coresets,” in 2024 Proceedings of the Symposium on Algorithm Engineering and Experiments, Alexandria, VA, United States, 2024, pp. 220–233.","apa":"Henzinger, M., Saulpic, D., & Sidl, L. (2024). Experimental evaluation of fully dynamic k-means via coresets. In 2024 Proceedings of the Symposium on Algorithm Engineering and Experiments (pp. 220–233). Alexandria, VA, United States: Society for Industrial and Applied Mathematics. https://doi.org/10.1137/1.9781611977929.17","chicago":"Henzinger, Monika, David Saulpic, and Leonhard Sidl. “Experimental Evaluation of Fully Dynamic K-Means via Coresets.” In 2024 Proceedings of the Symposium on Algorithm Engineering and Experiments, 220–33. Society for Industrial and Applied Mathematics, 2024. https://doi.org/10.1137/1.9781611977929.17.","ista":"Henzinger M, Saulpic D, Sidl L. 2024. Experimental evaluation of fully dynamic k-means via coresets. 2024 Proceedings of the Symposium on Algorithm Engineering and Experiments. ALENEX: Workshop on Algorithm Engineering and Experiments, 220–233.","short":"M. Henzinger, D. Saulpic, L. Sidl, in:, 2024 Proceedings of the Symposium on Algorithm Engineering and Experiments, Society for Industrial and Applied Mathematics, 2024, pp. 220–233.","ama":"Henzinger M, Saulpic D, Sidl L. Experimental evaluation of fully dynamic k-means via coresets. In: 2024 Proceedings of the Symposium on Algorithm Engineering and Experiments. Society for Industrial and Applied Mathematics; 2024:220-233. doi:10.1137/1.9781611977929.17","mla":"Henzinger, Monika, et al. “Experimental Evaluation of Fully Dynamic K-Means via Coresets.” 2024 Proceedings of the Symposium on Algorithm Engineering and Experiments, Society for Industrial and Applied Mathematics, 2024, pp. 220–33, doi:10.1137/1.9781611977929.17."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","scopus_import":"1","quality_controlled":"1","date_created":"2024-01-09T16:22:47Z","publication_identifier":{"eisbn":["9781611977929"]},"department":[{"_id":"MoHe"}],"date_published":"2024-01-04T00:00:00Z","page":"220-233","arxiv":1,"ec_funded":1,"doi":"10.1137/1.9781611977929.17","article_processing_charge":"No","abstract":[{"lang":"eng","text":"For a set of points in Rd, the Euclidean k-means problems consists of finding k centers such that the sum of distances squared from each data point to its closest center is minimized. Coresets are one the main tools developed recently to solve this problem in a big data context. They allow to compress the initial dataset while preserving its structure: running any algorithm on the coreset provides a guarantee almost equivalent to running it on the full data. In this work, we study coresets in a fully-dynamic setting: points are added and deleted with the goal to efficiently maintain a coreset with which a k-means solution can be computed. Based on an algorithm from Henzinger and Kale [ESA'20], we present an efficient and practical implementation of a fully dynamic coreset algorithm, that improves the running time by up to a factor of 20 compared to our non-optimized implementation of the algorithm by Henzinger and Kale, without sacrificing more than 7% on the quality of the k-means solution."}],"project":[{"_id":"bd9ca328-d553-11ed-ba76-dc4f890cfe62","name":"The design and evaluation of modern fully dynamic data structures","call_identifier":"H2020","grant_number":"101019564"},{"name":"Efficient algorithms","_id":"34def286-11ca-11ed-8bc3-da5948e1613c","grant_number":"Z00422"},{"_id":"bda196b2-d553-11ed-ba76-8e8ee6c21103","name":"Static and Dynamic Hierarchical Graph Decompositions","grant_number":"I05982"},{"grant_number":"P33775","name":"Fast Algorithms for a Reactive Network Layer","_id":"bd9e3a2e-d553-11ed-ba76-8aa684ce17fe"},{"name":"IST-BRIDGE: International postdoctoral program","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","grant_number":"101034413","call_identifier":"H2020"}],"conference":{"end_date":"2024-01-08","location":"Alexandria, VA, United States","start_date":"2024-01-07","name":"ALENEX: Workshop on Algorithm Engineering and Experiments"},"day":"04","_id":"14769","external_id":{"arxiv":["2310.18034"]},"author":[{"first_name":"Monika H","orcid":"0000-0002-5008-6530","full_name":"Henzinger, Monika H","last_name":"Henzinger","id":"540c9bbd-f2de-11ec-812d-d04a5be85630"},{"first_name":"David","full_name":"Saulpic, David","id":"f8e48cf0-b0ff-11ed-b0e9-b4c35598f964","last_name":"Saulpic"},{"last_name":"Sidl","id":"8b563fd0-b441-11ee-9101-a3891c61efa6","full_name":"Sidl, Leonhard","first_name":"Leonhard"}],"publisher":"Society for Industrial and Applied Mathematics","publication_status":"published","oa_version":"Preprint","oa":1,"acknowledgement":"This project has received funding from the Euro-pean Research Council (ERC) under the EuropeanUnion’s Horizon 2020 research and innovation programme (Grant agreement No. 101019564 “The De-sign of Modern Fully Dynamic Data Structures (Mo-DynStruct)” and the Austrian Science Fund (FWF)project Z 422-N, project “Static and Dynamic Hierar-chical Graph Decompositions”, I 5982-N, and project“Fast Algorithms for a Reactive Network Layer (Re-actNet)”, P 33775-N, with additional funding from thenetidee SCIENCE Stiftung, 2020–2024.D. Sauplic has received funding from the Euro-pean Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreementNo 101034413.","main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2310.18034","open_access":"1"}],"month":"01","date_updated":"2025-04-14T13:50:50Z"},{"publication":"Nature Communications","corr_author":"1","title":"Parity-conserving Cooper-pair transport and ideal superconducting diode in planar germanium","file":[{"file_id":"14825","access_level":"open_access","success":1,"creator":"dernst","relation":"main_file","file_size":2336595,"file_name":"2024_NatureComm_Valentini.pdf","checksum":"ef79173b45eeaf984ffa61ef2f8a52ab","date_created":"2024-01-17T11:03:00Z","date_updated":"2024-01-17T11:03:00Z","content_type":"application/pdf"}],"language":[{"iso":"eng"}],"pmid":1,"type":"journal_article","year":"2024","status":"public","volume":15,"APC_amount":"6468 EUR","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","citation":{"chicago":"Valentini, Marco, Oliver Sagi, Levon Baghumyan, Thijs de Gijsel, Jason Jung, Stefano Calcaterra, Andrea Ballabio, et al. “Parity-Conserving Cooper-Pair Transport and Ideal Superconducting Diode in Planar Germanium.” Nature Communications. Springer Nature, 2024. https://doi.org/10.1038/s41467-023-44114-0.","apa":"Valentini, M., Sagi, O., Baghumyan, L., de Gijsel, T., Jung, J., Calcaterra, S., … Katsaros, G. (2024). Parity-conserving Cooper-pair transport and ideal superconducting diode in planar germanium. Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-023-44114-0","ieee":"M. Valentini et al., “Parity-conserving Cooper-pair transport and ideal superconducting diode in planar germanium,” Nature Communications, vol. 15. Springer Nature, 2024.","mla":"Valentini, Marco, et al. “Parity-Conserving Cooper-Pair Transport and Ideal Superconducting Diode in Planar Germanium.” Nature Communications, vol. 15, 169, Springer Nature, 2024, doi:10.1038/s41467-023-44114-0.","ama":"Valentini M, Sagi O, Baghumyan L, et al. Parity-conserving Cooper-pair transport and ideal superconducting diode in planar germanium. Nature Communications. 2024;15. doi:10.1038/s41467-023-44114-0","ista":"Valentini M, Sagi O, Baghumyan L, de Gijsel T, Jung J, Calcaterra S, Ballabio A, Aguilera Servin JL, Aggarwal K, Janik M, Adletzberger T, Seoane Souto R, Leijnse M, Danon J, Schrade C, Bakkers E, Chrastina D, Isella G, Katsaros G. 2024. Parity-conserving Cooper-pair transport and ideal superconducting diode in planar germanium. Nature Communications. 15, 169.","short":"M. Valentini, O. Sagi, L. Baghumyan, T. de Gijsel, J. Jung, S. Calcaterra, A. Ballabio, J.L. Aguilera Servin, K. Aggarwal, M. Janik, T. Adletzberger, R. Seoane Souto, M. Leijnse, J. Danon, C. Schrade, E. Bakkers, D. Chrastina, G. Isella, G. Katsaros, Nature Communications 15 (2024)."},"scopus_import":"1","quality_controlled":"1","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"date_created":"2024-01-14T23:00:56Z","OA_place":"publisher","isi":1,"department":[{"_id":"GeKa"}],"publication_identifier":{"eissn":["2041-1723"]},"acknowledged_ssus":[{"_id":"M-Shop"},{"_id":"NanoFab"}],"date_published":"2024-01-02T00:00:00Z","article_number":"169","intvolume":" 15","DOAJ_listed":"1","ec_funded":1,"ddc":["530"],"doi":"10.1038/s41467-023-44114-0","article_processing_charge":"Yes","abstract":[{"lang":"eng","text":"Superconductor/semiconductor hybrid devices have attracted increasing interest in the past years. Superconducting electronics aims to complement semiconductor technology, while hybrid architectures are at the forefront of new ideas such as topological superconductivity and protected qubits. In this work, we engineer the induced superconductivity in two-dimensional germanium hole gas by varying the distance between the quantum well and the aluminum. We demonstrate a hard superconducting gap and realize an electrically and flux tunable superconducting diode using a superconducting quantum interference device (SQUID). This allows to tune the current phase relation (CPR), to a regime where single Cooper pair tunneling is suppressed, creating a sin(2y) CPR. Shapiro experiments complement this interpretation and the microwave drive allows to create a diode with ≈ 100% efficiency. The reported results open up the path towards integration of spin qubit devices, microwave resonators and (protected) superconducting qubits on the same silicon technology compatible platform."}],"project":[{"name":"TOPOLOGICALLY PROTECTED AND SCALABLE QUANTUM BITS","_id":"237E5020-32DE-11EA-91FC-C7463DDC885E","grant_number":"862046","call_identifier":"H2020"},{"grant_number":"101069515","_id":"34c0acea-11ca-11ed-8bc3-8775e10fd452","name":"Integrated Germanium Quantum Technology"},{"grant_number":"101115315","name":"Quantum bits with Kitaev Transmons","_id":"bdc2ca30-d553-11ed-ba76-cf164a5bb811"},{"name":"Towards scalable hut wire quantum devices","_id":"237B3DA4-32DE-11EA-91FC-C7463DDC885E","call_identifier":"FWF","grant_number":"P32235"},{"name":"Merging spin and superconducting qubits in planar Ge","_id":"bd8bd29e-d553-11ed-ba76-f0070d4b237a","grant_number":"P36507"},{"grant_number":"F8606","name":"Center for Correlated Quantum Materials and Solid State Quantum Systems: Conventional and unconventional topological superconductors","_id":"34a66131-11ca-11ed-8bc3-a31681c6b03e"},{"call_identifier":"FWF","name":"FWF Open Access Fund","_id":"3AC91DDA-15DF-11EA-824D-93A3E7B544D1"}],"day":"02","_id":"14793","publication_status":"published","publisher":"Springer Nature","author":[{"last_name":"Valentini","id":"C0BB2FAC-D767-11E9-B658-BC13E6697425","first_name":"Marco","full_name":"Valentini, Marco"},{"last_name":"Sagi","id":"71616374-A8E9-11E9-A7CA-09ECE5697425","first_name":"Oliver","full_name":"Sagi, Oliver"},{"id":"7aa1f788-b527-11ee-aa9e-e6111a79e0c7","last_name":"Baghumyan","first_name":"Levon","full_name":"Baghumyan, Levon"},{"first_name":"Thijs","full_name":"de Gijsel, Thijs","id":"a0ece13c-b527-11ee-929d-bad130106eee","last_name":"de Gijsel"},{"first_name":"Jason","full_name":"Jung, Jason","last_name":"Jung","id":"4C9ACE7A-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Calcaterra, Stefano","first_name":"Stefano","last_name":"Calcaterra"},{"first_name":"Andrea","full_name":"Ballabio, Andrea","last_name":"Ballabio"},{"orcid":"0000-0002-2862-8372","full_name":"Aguilera Servin, Juan L","first_name":"Juan L","last_name":"Aguilera Servin","id":"2A67C376-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Aggarwal","id":"b22ab905-3539-11eb-84c3-fc159dcd79cb","orcid":"0000-0001-9985-9293","full_name":"Aggarwal, Kushagra","first_name":"Kushagra"},{"first_name":"Marian","full_name":"Janik, Marian","orcid":"0009-0003-9037-8831","id":"396A1950-F248-11E8-B48F-1D18A9856A87","last_name":"Janik"},{"id":"38756BB2-F248-11E8-B48F-1D18A9856A87","last_name":"Adletzberger","full_name":"Adletzberger, Thomas","first_name":"Thomas"},{"first_name":"Rubén","full_name":"Seoane Souto, Rubén","last_name":"Seoane Souto"},{"last_name":"Leijnse","full_name":"Leijnse, Martin","first_name":"Martin"},{"last_name":"Danon","first_name":"Jeroen","full_name":"Danon, Jeroen"},{"first_name":"Constantin","full_name":"Schrade, Constantin","last_name":"Schrade"},{"first_name":"Erik","full_name":"Bakkers, Erik","last_name":"Bakkers"},{"last_name":"Chrastina","full_name":"Chrastina, Daniel","first_name":"Daniel"},{"full_name":"Isella, Giovanni","first_name":"Giovanni","last_name":"Isella"},{"orcid":"0000-0001-8342-202X","full_name":"Katsaros, Georgios","first_name":"Georgios","last_name":"Katsaros","id":"38DB5788-F248-11E8-B48F-1D18A9856A87"}],"external_id":{"isi":["001142794000839"],"pmid":["38167818"]},"file_date_updated":"2024-01-17T11:03:00Z","oa_version":"Published Version","article_type":"original","oa":1,"acknowledgement":"We acknowledge Alexander Brinkmann, Alessandro Crippa, Francesco Giazotto, Andrew Higginbotham, Andrea Iorio, Giordano Scappucci, Christian Schonenberger, and Lukas Splitthoff for helpful discussions. We thank Marcel Verheijen for the support in the TEM analysis. This research and related results were made possible with the support of the NOMIS\r\nFoundation. It was supported by the Scientific Service Units of ISTA through resources provided by the MIBA Machine Shop and the nanofabrication facility, the European Union’s Horizon 2020 research andinnovation programme under Grant Agreement No 862046, the HORIZONRIA\r\n101069515 project, the European Innovation Council Pathfinder grant no. 101115315 (QuKiT), and the FWF Projects #P-32235, #P-36507 and #F-8606. For the purpose of open access, the authors have applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission. R.S.S. acknowledges Spanish CM “Talento Program\"\r\nProject No. 2022-T1/IND-24070. J.J. acknowledges European Research Council TOCINA 834290.","OA_type":"gold","month":"01","has_accepted_license":"1","date_updated":"2025-10-15T06:31:47Z"},{"acknowledgement":"We thank Florian Pauler for discussion and his expert technical support. This research was supported by the Scientific Service Units (SSU) at IST Austria through resources provided by the Imaging and Optics Facility (IOF) and Preclinical Facility (PCF). A.H.H. was a recipient of a DOC Fellowship (24812) of the Austrian Academy of Sciences.","month":"03","date_updated":"2025-04-15T07:32:40Z","has_accepted_license":"1","file_date_updated":"2024-07-16T12:04:46Z","oa_version":"Published Version","article_type":"review","oa":1,"abstract":[{"text":"Mosaic analysis with double markers (MADM) technology enables the sparse labeling of genetically defined neurons. We present a protocol for time-lapse imaging of cortical projection neuron migration in mice using MADM. We describe steps for the isolation, culturing, and 4D imaging of neuronal dynamics in MADM-labeled brain tissue. While this protocol is compatible with other single-cell labeling methods, the MADM approach provides a genetic platform for the functional assessment of cell-autonomous candidate gene function and the relative contribution of non-cell-autonomous effects.\r\n\r\nFor complete details on the use and execution of this protocol, please refer to Hansen et al. (2022),1 Contreras et al. (2021),2 and Amberg and Hippenmeyer (2021).3","lang":"eng"}],"article_processing_charge":"Yes","doi":"10.1016/j.xpro.2023.102795","day":"15","project":[{"_id":"2625A13E-B435-11E9-9278-68D0E5697425","name":"Molecular mechanisms of radial neuronal migration","grant_number":"24812"}],"_id":"14794","publication_status":"published","author":[{"full_name":"Hansen, Andi H","first_name":"Andi H","id":"38853E16-F248-11E8-B48F-1D18A9856A87","last_name":"Hansen"},{"last_name":"Hippenmeyer","id":"37B36620-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-2279-1061","full_name":"Hippenmeyer, Simon","first_name":"Simon"}],"external_id":{"pmid":["38165800"]},"publisher":"Elsevier","ddc":["570"],"article_number":"102795","date_published":"2024-03-15T00:00:00Z","intvolume":" 5","publication_identifier":{"eissn":["2666-1667"]},"department":[{"_id":"SiHi"}],"acknowledged_ssus":[{"_id":"Bio"},{"_id":"PreCl"}],"volume":5,"status":"public","citation":{"chicago":"Hansen, Andi H, and Simon Hippenmeyer. “Time-Lapse Imaging of Cortical Projection Neuron Migration in Mice Using Mosaic Analysis with Double Markers.” STAR Protocols. Elsevier, 2024. https://doi.org/10.1016/j.xpro.2023.102795.","apa":"Hansen, A. H., & Hippenmeyer, S. (2024). Time-lapse imaging of cortical projection neuron migration in mice using mosaic analysis with double markers. STAR Protocols. Elsevier. https://doi.org/10.1016/j.xpro.2023.102795","ieee":"A. H. Hansen and S. Hippenmeyer, “Time-lapse imaging of cortical projection neuron migration in mice using mosaic analysis with double markers,” STAR Protocols, vol. 5, no. 1. Elsevier, 2024.","mla":"Hansen, Andi H., and Simon Hippenmeyer. “Time-Lapse Imaging of Cortical Projection Neuron Migration in Mice Using Mosaic Analysis with Double Markers.” STAR Protocols, vol. 5, no. 1, 102795, Elsevier, 2024, doi:10.1016/j.xpro.2023.102795.","ama":"Hansen AH, Hippenmeyer S. Time-lapse imaging of cortical projection neuron migration in mice using mosaic analysis with double markers. STAR Protocols. 2024;5(1). doi:10.1016/j.xpro.2023.102795","ista":"Hansen AH, Hippenmeyer S. 2024. Time-lapse imaging of cortical projection neuron migration in mice using mosaic analysis with double markers. STAR Protocols. 5(1), 102795.","short":"A.H. Hansen, S. Hippenmeyer, STAR Protocols 5 (2024)."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","related_material":{"link":[{"relation":"software","url":"http://github.com/hippenmeyerlab"}]},"quality_controlled":"1","scopus_import":"1","date_created":"2024-01-14T23:00:56Z","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"title":"Time-lapse imaging of cortical projection neuron migration in mice using mosaic analysis with double markers","publication":"STAR Protocols","corr_author":"1","language":[{"iso":"eng"}],"file":[{"file_id":"17264","access_level":"open_access","success":1,"creator":"dernst","relation":"main_file","file_size":3758943,"file_name":"2024_STARProtoc_Hansen.pdf","checksum":"4644d537451c5c114a9d7c7829b65bba","date_created":"2024-07-16T12:04:46Z","date_updated":"2024-07-16T12:04:46Z","content_type":"application/pdf"}],"pmid":1,"type":"journal_article","issue":"1","year":"2024"},{"pmid":1,"issue":"1","type":"journal_article","year":"2024","title":"Adhesion-induced cortical flows pattern E-cadherin-mediated cell contacts","corr_author":"1","publication":"Current Biology","language":[{"iso":"eng"}],"file":[{"content_type":"application/pdf","date_updated":"2024-01-16T10:53:31Z","date_created":"2024-01-16T10:53:31Z","checksum":"51220b76d72a614208f84bdbfbaf9b72","file_name":"2024_CurrentBiology_Arslan.pdf","file_size":5183861,"relation":"main_file","creator":"dernst","success":1,"access_level":"open_access","file_id":"14813"}],"quality_controlled":"1","scopus_import":"1","date_created":"2024-01-14T23:00:56Z","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"volume":34,"status":"public","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","citation":{"ista":"Arslan FN, Hannezo EB, Merrin J, Loose M, Heisenberg C-PJ. 2024. Adhesion-induced cortical flows pattern E-cadherin-mediated cell contacts. Current Biology. 34(1), 171–182.e8.","short":"F.N. Arslan, E.B. Hannezo, J. Merrin, M. Loose, C.-P.J. Heisenberg, Current Biology 34 (2024) 171–182.e8.","mla":"Arslan, Feyza N., et al. “Adhesion-Induced Cortical Flows Pattern E-Cadherin-Mediated Cell Contacts.” Current Biology, vol. 34, no. 1, Elsevier, 2024, p. 171–182.e8, doi:10.1016/j.cub.2023.11.067.","ama":"Arslan FN, Hannezo EB, Merrin J, Loose M, Heisenberg C-PJ. Adhesion-induced cortical flows pattern E-cadherin-mediated cell contacts. Current Biology. 2024;34(1):171-182.e8. doi:10.1016/j.cub.2023.11.067","apa":"Arslan, F. N., Hannezo, E. B., Merrin, J., Loose, M., & Heisenberg, C.-P. J. (2024). Adhesion-induced cortical flows pattern E-cadherin-mediated cell contacts. Current Biology. Elsevier. https://doi.org/10.1016/j.cub.2023.11.067","ieee":"F. N. Arslan, E. B. Hannezo, J. Merrin, M. Loose, and C.-P. J. Heisenberg, “Adhesion-induced cortical flows pattern E-cadherin-mediated cell contacts,” Current Biology, vol. 34, no. 1. Elsevier, p. 171–182.e8, 2024.","chicago":"Arslan, Feyza N, Edouard B Hannezo, Jack Merrin, Martin Loose, and Carl-Philipp J Heisenberg. “Adhesion-Induced Cortical Flows Pattern E-Cadherin-Mediated Cell Contacts.” Current Biology. Elsevier, 2024. https://doi.org/10.1016/j.cub.2023.11.067."},"department":[{"_id":"CaHe"},{"_id":"EdHa"},{"_id":"MaLo"},{"_id":"NanoFab"}],"publication_identifier":{"eissn":["1879-0445"],"issn":["0960-9822"]},"isi":1,"acknowledged_ssus":[{"_id":"Bio"},{"_id":"PreCl"}],"intvolume":" 34","date_published":"2024-01-08T00:00:00Z","page":"171-182.e8","ddc":["570"],"ec_funded":1,"day":"08","project":[{"call_identifier":"H2020","grant_number":"742573","name":"Interaction and feedback between cell mechanics and fate specification in vertebrate gastrulation","_id":"260F1432-B435-11E9-9278-68D0E5697425"}],"external_id":{"pmid":["38134934"],"isi":["001154500400001"]},"_id":"14795","publication_status":"published","author":[{"first_name":"Feyza N","orcid":"0000-0001-5809-9566","full_name":"Arslan, Feyza N","last_name":"Arslan","id":"49DA7910-F248-11E8-B48F-1D18A9856A87"},{"id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","last_name":"Hannezo","first_name":"Edouard B","full_name":"Hannezo, Edouard B","orcid":"0000-0001-6005-1561"},{"first_name":"Jack","full_name":"Merrin, Jack","orcid":"0000-0001-5145-4609","id":"4515C308-F248-11E8-B48F-1D18A9856A87","last_name":"Merrin"},{"orcid":"0000-0001-7309-9724","full_name":"Loose, Martin","first_name":"Martin","last_name":"Loose","id":"462D4284-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Carl-Philipp J","full_name":"Heisenberg, Carl-Philipp J","orcid":"0000-0002-0912-4566","id":"39427864-F248-11E8-B48F-1D18A9856A87","last_name":"Heisenberg"}],"publisher":"Elsevier","abstract":[{"lang":"eng","text":"Metazoan development relies on the formation and remodeling of cell-cell contacts. Dynamic reorganization of adhesion receptors and the actomyosin cell cortex in space and time plays a central role in cell-cell contact formation and maturation. Nevertheless, how this process is mechanistically achieved when new contacts are formed remains unclear. Here, by building a biomimetic assay composed of progenitor cells adhering to supported lipid bilayers functionalized with E-cadherin ectodomains, we show that cortical F-actin flows, driven by the depletion of myosin-2 at the cell contact center, mediate the dynamic reorganization of adhesion receptors and cell cortex at the contact. E-cadherin-dependent downregulation of the small GTPase RhoA at the forming contact leads to both a depletion of myosin-2 and a decrease of F-actin at the contact center. At the contact rim, in contrast, myosin-2 becomes enriched by the retraction of bleb-like protrusions, resulting in a cortical tension gradient from the contact rim to its center. This tension gradient, in turn, triggers centrifugal F-actin flows, leading to further accumulation of F-actin at the contact rim and the progressive redistribution of E-cadherin from the contact center to the rim. Eventually, this combination of actomyosin downregulation and flows at the contact determines the characteristic molecular organization, with E-cadherin and F-actin accumulating at the contact rim, where they are needed to mechanically link the contractile cortices of the adhering cells."}],"article_processing_charge":"Yes (via OA deal)","doi":"10.1016/j.cub.2023.11.067","oa":1,"article_type":"original","oa_version":"Published Version","file_date_updated":"2024-01-16T10:53:31Z","month":"01","date_updated":"2025-09-04T11:39:10Z","has_accepted_license":"1","acknowledgement":"We are grateful to Edwin Munro for their feedback and help with the single particle analysis. We thank members of the Heisenberg and Loose labs for their help and feedback on the manuscript, notably Xin Tong for making the PCS2-mCherry-AHPH plasmid. Finally, we thank the Aquatics and Imaging & Optics facilities of ISTA for their continuous support, especially Yann Cesbron for assistance with the laser cutter. This work was supported by an ERC\r\nAdvanced Grant (MECSPEC) to C.-P.H."},{"oa":1,"article_type":"original","file_date_updated":"2025-01-09T08:10:54Z","oa_version":"Published Version","has_accepted_license":"1","date_updated":"2025-09-04T11:43:43Z","month":"10","OA_type":"hybrid","acknowledgement":"NC has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant agreement No 948819).\r\nFM is supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) through the SPP 2265 Random Geometric Systems. FM has been funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy EXC 2044 -390685587, Mathematics Münster: Dynamics–Geometry–Structure. FM has been funded by the Max Planck Institute for Mathematics in the Sciences.","ddc":["510"],"ec_funded":1,"_id":"14797","publisher":"Springer Nature","publication_status":"published","external_id":{"isi":["001136206200002"],"arxiv":["2303.00353"]},"author":[{"last_name":"Clozeau","id":"fea1b376-906f-11eb-847d-b2c0cf46455b","full_name":"Clozeau, Nicolas","first_name":"Nicolas"},{"full_name":"Mattesini, Francesco","first_name":"Francesco","last_name":"Mattesini"}],"project":[{"_id":"0aa76401-070f-11eb-9043-b5bb049fa26d","name":"Bridging Scales in Random Materials","call_identifier":"H2020","grant_number":"948819"}],"day":"01","doi":"10.1007/s00440-023-01254-0","article_processing_charge":"Yes (in subscription journal)","abstract":[{"lang":"eng","text":"We study a random matching problem on closed compact 2 -dimensional Riemannian manifolds (with respect to the squared Riemannian distance), with samples of random points whose common law is absolutely continuous with respect to the volume measure with strictly positive and bounded density. We show that given two sequences of numbers n and m=m(n) of points, asymptotically equivalent as n goes to infinity, the optimal transport plan between the two empirical measures μn and νm is quantitatively well-approximated by (Id,exp(∇hn))#μn where hn solves a linear elliptic PDE obtained by a regularized first-order linearization of the Monge-Ampère equation. This is obtained in the case of samples of correlated random points for which a stretched exponential decay of the α -mixing coefficient holds and for a class of discrete-time Markov chains having a unique absolutely continuous invariant measure with respect to the volume measure."}],"isi":1,"department":[{"_id":"JuFi"}],"publication_identifier":{"eissn":["1432-2064"],"issn":["0178-8051"]},"OA_place":"publisher","intvolume":" 190","page":"485-541","arxiv":1,"date_published":"2024-10-01T00:00:00Z","type":"journal_article","year":"2024","file":[{"creator":"dernst","success":1,"file_id":"18788","access_level":"open_access","content_type":"application/pdf","date_created":"2025-01-09T08:10:54Z","date_updated":"2025-01-09T08:10:54Z","file_name":"2024_ProbTheoryRelatFields_Clozeau.pdf","checksum":"34f44cad6a210ff66791ee37e590af2c","file_size":880117,"relation":"main_file"}],"language":[{"iso":"eng"}],"corr_author":"1","publication":"Probability Theory and Related Fields","title":"Annealed quantitative estimates for the quadratic 2D-discrete random matching problem","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"date_created":"2024-01-14T23:00:57Z","scopus_import":"1","quality_controlled":"1","citation":{"chicago":"Clozeau, Nicolas, and Francesco Mattesini. “Annealed Quantitative Estimates for the Quadratic 2D-Discrete Random Matching Problem.” Probability Theory and Related Fields. Springer Nature, 2024. https://doi.org/10.1007/s00440-023-01254-0.","ieee":"N. Clozeau and F. Mattesini, “Annealed quantitative estimates for the quadratic 2D-discrete random matching problem,” Probability Theory and Related Fields, vol. 190. Springer Nature, pp. 485–541, 2024.","apa":"Clozeau, N., & Mattesini, F. (2024). Annealed quantitative estimates for the quadratic 2D-discrete random matching problem. Probability Theory and Related Fields. Springer Nature. https://doi.org/10.1007/s00440-023-01254-0","ama":"Clozeau N, Mattesini F. Annealed quantitative estimates for the quadratic 2D-discrete random matching problem. Probability Theory and Related Fields. 2024;190:485-541. doi:10.1007/s00440-023-01254-0","mla":"Clozeau, Nicolas, and Francesco Mattesini. “Annealed Quantitative Estimates for the Quadratic 2D-Discrete Random Matching Problem.” Probability Theory and Related Fields, vol. 190, Springer Nature, 2024, pp. 485–541, doi:10.1007/s00440-023-01254-0.","ista":"Clozeau N, Mattesini F. 2024. Annealed quantitative estimates for the quadratic 2D-discrete random matching problem. Probability Theory and Related Fields. 190, 485–541.","short":"N. Clozeau, F. Mattesini, Probability Theory and Related Fields 190 (2024) 485–541."},"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","status":"public","volume":190},{"article_type":"original","oa":1,"oa_version":"Published Version","file_date_updated":"2024-01-17T08:53:16Z","keyword":["Atomic and Molecular Physics","and Optics","Electronic","Optical and Magnetic Materials"],"has_accepted_license":"1","date_updated":"2025-09-04T12:13:27Z","month":"01","OA_type":"gold","acknowledgement":"We thank Rishabh Sahu and Sebastian Wald for technical contributions to the experiment. Funding by Institute of Science and Technology Austria.","ddc":["530"],"_id":"14802","author":[{"last_name":"Diorico","id":"2E054C4C-F248-11E8-B48F-1D18A9856A87","first_name":"Fritz R","orcid":"0000-0002-4947-8924","full_name":"Diorico, Fritz R"},{"first_name":"Artem","full_name":"Zhutov, Artem","id":"0f02ed6a-b514-11ee-b891-8379c5f19cb7","last_name":"Zhutov"},{"last_name":"Hosten","id":"4C02D85E-F248-11E8-B48F-1D18A9856A87","first_name":"Onur","orcid":"0000-0002-2031-204X","full_name":"Hosten, Onur"}],"external_id":{"isi":["001202817000004"]},"publication_status":"published","publisher":"Optica Publishing Group","day":"20","doi":"10.1364/optica.507451","article_processing_charge":"Yes","abstract":[{"lang":"eng","text":"Frequency-stable lasers form the back bone of precision measurements in science and technology. Such lasers typically attain their stability through frequency locking to reference cavities. State-of-the-art locking performances to date had been achieved using frequency modulation based methods, complemented with active drift cancellation systems. We demonstrate an all passive, modulation-free laser-cavity locking technique (squash locking) that utilizes changes in spatial beam ellipticity for error signal generation, and a coherent polarization post-selection for noise resilience. By comparing two identically built proof-of-principle systems, we show a frequency locking instability of 5×10−7 relative to the cavity linewidth at 10 s averaging. The results surpass the demonstrated performances of methods engineered over the last five decades, potentially enabling an advancement in the precision control of lasers, while creating avenues for bridging the performance gaps between industrial grade lasers with scientific ones due to the afforded simplicity and scalability."}],"isi":1,"publication_identifier":{"issn":["2334-2536"]},"department":[{"_id":"OnHo"}],"OA_place":"publisher","DOAJ_listed":"1","intvolume":" 11","page":"26-31","date_published":"2024-01-20T00:00:00Z","issue":"1","type":"journal_article","year":"2024","file":[{"success":1,"file_id":"14824","access_level":"open_access","creator":"dernst","file_name":"2023_Optica_Diorico.pdf","checksum":"eb99ca7d0fe73e22f121875175546ed7","relation":"main_file","file_size":4558986,"content_type":"application/pdf","date_created":"2024-01-17T08:53:16Z","date_updated":"2024-01-17T08:53:16Z"}],"language":[{"iso":"eng"}],"corr_author":"1","publication":"Optica","title":"Laser-cavity locking utilizing beam ellipticity: accessing the 10−7 instability scale relative to cavity linewidth","date_created":"2024-01-15T10:25:38Z","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"quality_controlled":"1","scopus_import":"1","APC_amount":"3393,38 EUR","citation":{"chicago":"Diorico, Fritz R, Artem Zhutov, and Onur Hosten. “Laser-Cavity Locking Utilizing Beam Ellipticity: Accessing the 10−7 Instability Scale Relative to Cavity Linewidth.” Optica. Optica Publishing Group, 2024. https://doi.org/10.1364/optica.507451.","ieee":"F. R. Diorico, A. Zhutov, and O. Hosten, “Laser-cavity locking utilizing beam ellipticity: accessing the 10−7 instability scale relative to cavity linewidth,” Optica, vol. 11, no. 1. Optica Publishing Group, pp. 26–31, 2024.","apa":"Diorico, F. R., Zhutov, A., & Hosten, O. (2024). Laser-cavity locking utilizing beam ellipticity: accessing the 10−7 instability scale relative to cavity linewidth. Optica. Optica Publishing Group. https://doi.org/10.1364/optica.507451","ama":"Diorico FR, Zhutov A, Hosten O. Laser-cavity locking utilizing beam ellipticity: accessing the 10−7 instability scale relative to cavity linewidth. Optica. 2024;11(1):26-31. doi:10.1364/optica.507451","mla":"Diorico, Fritz R., et al. “Laser-Cavity Locking Utilizing Beam Ellipticity: Accessing the 10−7 Instability Scale Relative to Cavity Linewidth.” Optica, vol. 11, no. 1, Optica Publishing Group, 2024, pp. 26–31, doi:10.1364/optica.507451.","short":"F.R. Diorico, A. Zhutov, O. Hosten, Optica 11 (2024) 26–31.","ista":"Diorico FR, Zhutov A, Hosten O. 2024. Laser-cavity locking utilizing beam ellipticity: accessing the 10−7 instability scale relative to cavity linewidth. Optica. 11(1), 26–31."},"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","status":"public","volume":11},{"article_number":"114353","date_published":"2024-03-21T00:00:00Z","intvolume":" 989","isi":1,"department":[{"_id":"KrCh"},{"_id":"KrPi"}],"publication_identifier":{"issn":["0304-3975"]},"status":"public","volume":989,"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","citation":{"ista":"Schmid S, Svoboda J, Yeo MX. 2024. Weighted packet selection for rechargeable links in cryptocurrency networks: Complexity and approximation. Theoretical Computer Science. 989, 114353.","short":"S. Schmid, J. Svoboda, M.X. Yeo, Theoretical Computer Science 989 (2024).","mla":"Schmid, Stefan, et al. “Weighted Packet Selection for Rechargeable Links in Cryptocurrency Networks: Complexity and Approximation.” Theoretical Computer Science, vol. 989, 114353, Elsevier, 2024, doi:10.1016/j.tcs.2023.114353.","ama":"Schmid S, Svoboda J, Yeo MX. Weighted packet selection for rechargeable links in cryptocurrency networks: Complexity and approximation. Theoretical Computer Science. 2024;989. doi:10.1016/j.tcs.2023.114353","apa":"Schmid, S., Svoboda, J., & Yeo, M. X. (2024). Weighted packet selection for rechargeable links in cryptocurrency networks: Complexity and approximation. Theoretical Computer Science. Elsevier. https://doi.org/10.1016/j.tcs.2023.114353","ieee":"S. Schmid, J. Svoboda, and M. X. Yeo, “Weighted packet selection for rechargeable links in cryptocurrency networks: Complexity and approximation,” Theoretical Computer Science, vol. 989. Elsevier, 2024.","chicago":"Schmid, Stefan, Jakub Svoboda, and Michelle X Yeo. “Weighted Packet Selection for Rechargeable Links in Cryptocurrency Networks: Complexity and Approximation.” Theoretical Computer Science. Elsevier, 2024. https://doi.org/10.1016/j.tcs.2023.114353."},"quality_controlled":"1","scopus_import":"1","related_material":{"record":[{"status":"public","id":"19985","relation":"earlier_version"}]},"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"date_created":"2024-01-16T13:40:41Z","publication":"Theoretical Computer Science","corr_author":"1","title":"Weighted packet selection for rechargeable links in cryptocurrency networks: Complexity and approximation","file":[{"date_created":"2024-07-16T12:02:25Z","date_updated":"2024-07-16T12:02:25Z","content_type":"application/pdf","file_size":603570,"relation":"main_file","file_name":"2024_TheorComputerScience_Schmid.pdf","checksum":"efd5b7e738bf845312ba53889a3e13e4","creator":"dernst","access_level":"open_access","file_id":"17263","success":1}],"language":[{"iso":"eng"}],"year":"2024","type":"journal_article","acknowledgement":"We thank Mahsa Bastankhah and Mohammad Ali Maddah-Ali for fruitful discussions about different variants of the problem. This work is supported by the European Research Council (ERC) Consolidator Project 864228 (AdjustNet), 2020-2025, the ERC CoG 863818 (ForM-SMArt), and the German Research Foundation (DFG) grant 470029389 (FlexNets), 2021-2024.","month":"03","has_accepted_license":"1","date_updated":"2025-12-02T14:02:37Z","file_date_updated":"2024-07-16T12:02:25Z","keyword":["General Computer Science","Theoretical Computer Science"],"oa_version":"Published Version","oa":1,"article_type":"original","doi":"10.1016/j.tcs.2023.114353","abstract":[{"text":"We consider a natural problem dealing with weighted packet selection across a rechargeable link, which e.g., finds applications in cryptocurrency networks. The capacity of a link (u, v) is determined by how many nodes u and v allocate for this link. Specifically, the input is a finite ordered sequence of packets that arrive in both directions along a link. Given (u, v) and a packet of weight x going from u to v, node u can either accept or reject the packet. If u accepts the packet, the capacity on link (u, v) decreases by x. Correspondingly, v's capacity on \r\n increases by x. If a node rejects the packet, this will entail a cost affinely linear in the weight of the packet. A link is “rechargeable” in the sense that the total capacity of the link has to remain constant, but the allocation of capacity at the ends of the link can depend arbitrarily on the nodes' decisions. The goal is to minimise the sum of the capacity injected into the link and the cost of rejecting packets. We show that the problem is NP-hard, but can be approximated efficiently with a ratio of (1+E) . (1+3) for some arbitrary E>0.","lang":"eng"}],"article_processing_charge":"Yes (via OA deal)","project":[{"_id":"0599E47C-7A3F-11EA-A408-12923DDC885E","name":"Formal Methods for Stochastic Models: Algorithms and Applications","call_identifier":"H2020","grant_number":"863818"}],"day":"21","publisher":"Elsevier","_id":"14820","publication_status":"published","external_id":{"isi":["001168211400001"]},"author":[{"first_name":"Stefan","full_name":"Schmid, Stefan","last_name":"Schmid"},{"id":"130759D2-D7DD-11E9-87D2-DE0DE6697425","last_name":"Svoboda","full_name":"Svoboda, Jakub","orcid":"0000-0002-1419-3267","first_name":"Jakub"},{"last_name":"Yeo","id":"2D82B818-F248-11E8-B48F-1D18A9856A87","orcid":"0009-0001-3676-4809","full_name":"Yeo, Michelle X","first_name":"Michelle X"}],"ec_funded":1,"ddc":["000"]},{"date_created":"2024-01-17T12:45:40Z","tmp":{"short":"CC BY-NC (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","image":"/images/cc_by_nc.png"},"related_material":{"record":[{"relation":"dissertation_contains","id":"19395","status":"public"}]},"quality_controlled":"1","scopus_import":"1","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","citation":{"apa":"Kuhn, A., Roosjen, M., Mutte, S., Dubey, S. M., Carrillo Carrasco, V. P., Boeren, S., … Weijers, D. (2024). RAF-like protein kinases mediate a deeply conserved, rapid auxin response. Cell. Elsevier. https://doi.org/10.1016/j.cell.2023.11.021","ieee":"A. Kuhn et al., “RAF-like protein kinases mediate a deeply conserved, rapid auxin response,” Cell, vol. 187, no. 1. Elsevier, p. 130–148.e17, 2024.","chicago":"Kuhn, Andre, Mark Roosjen, Sumanth Mutte, Shiv Mani Dubey, Vanessa Polet Carrillo Carrasco, Sjef Boeren, Aline Monzer, et al. “RAF-like Protein Kinases Mediate a Deeply Conserved, Rapid Auxin Response.” Cell. Elsevier, 2024. https://doi.org/10.1016/j.cell.2023.11.021.","ista":"Kuhn A, Roosjen M, Mutte S, Dubey SM, Carrillo Carrasco VP, Boeren S, Monzer A, Koehorst J, Kohchi T, Nishihama R, Fendrych M, Sprakel J, Friml J, Weijers D. 2024. RAF-like protein kinases mediate a deeply conserved, rapid auxin response. Cell. 187(1), 130–148.e17.","short":"A. Kuhn, M. Roosjen, S. Mutte, S.M. Dubey, V.P. Carrillo Carrasco, S. Boeren, A. Monzer, J. Koehorst, T. Kohchi, R. Nishihama, M. Fendrych, J. Sprakel, J. Friml, D. Weijers, Cell 187 (2024) 130–148.e17.","mla":"Kuhn, Andre, et al. “RAF-like Protein Kinases Mediate a Deeply Conserved, Rapid Auxin Response.” Cell, vol. 187, no. 1, Elsevier, 2024, p. 130–148.e17, doi:10.1016/j.cell.2023.11.021.","ama":"Kuhn A, Roosjen M, Mutte S, et al. RAF-like protein kinases mediate a deeply conserved, rapid auxin response. Cell. 2024;187(1):130-148.e17. doi:10.1016/j.cell.2023.11.021"},"volume":187,"status":"public","issue":"1","type":"journal_article","year":"2024","pmid":1,"language":[{"iso":"eng"}],"file":[{"creator":"dernst","access_level":"open_access","file_id":"14874","success":1,"date_created":"2024-01-22T13:41:41Z","date_updated":"2024-01-22T13:41:41Z","content_type":"application/pdf","relation":"main_file","file_size":13194060,"file_name":"2024_Cell_Kuhn.pdf","checksum":"06fd236a9ee0b46ccb05f44695bfc34b"}],"title":"RAF-like protein kinases mediate a deeply conserved, rapid auxin response","publication":"Cell","intvolume":" 187","page":"130-148.e17","date_published":"2024-01-04T00:00:00Z","license":"https://creativecommons.org/licenses/by-nc/4.0/","publication_identifier":{"eissn":["1097-4172"],"issn":["0092-8674"]},"department":[{"_id":"JiFr"}],"isi":1,"_id":"14826","publication_status":"published","author":[{"last_name":"Kuhn","first_name":"Andre","full_name":"Kuhn, Andre"},{"full_name":"Roosjen, Mark","first_name":"Mark","last_name":"Roosjen"},{"last_name":"Mutte","first_name":"Sumanth","full_name":"Mutte, Sumanth"},{"last_name":"Dubey","first_name":"Shiv Mani","full_name":"Dubey, Shiv Mani"},{"full_name":"Carrillo Carrasco, Vanessa Polet","first_name":"Vanessa Polet","last_name":"Carrillo Carrasco"},{"first_name":"Sjef","full_name":"Boeren, Sjef","last_name":"Boeren"},{"last_name":"Monzer","id":"2DB5D88C-D7B3-11E9-B8FD-7907E6697425","full_name":"Monzer, Aline","first_name":"Aline"},{"first_name":"Jasper","full_name":"Koehorst, Jasper","last_name":"Koehorst"},{"first_name":"Takayuki","full_name":"Kohchi, Takayuki","last_name":"Kohchi"},{"last_name":"Nishihama","full_name":"Nishihama, Ryuichi","first_name":"Ryuichi"},{"first_name":"Matyas","orcid":"0000-0002-9767-8699","full_name":"Fendrych, Matyas","last_name":"Fendrych","id":"43905548-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Sprakel, Joris","first_name":"Joris","last_name":"Sprakel"},{"last_name":"Friml","id":"4159519E-F248-11E8-B48F-1D18A9856A87","first_name":"Jiří","orcid":"0000-0002-8302-7596","full_name":"Friml, Jiří"},{"full_name":"Weijers, Dolf","first_name":"Dolf","last_name":"Weijers"}],"publisher":"Elsevier","external_id":{"pmid":["38128538"],"isi":["001152705700001"]},"day":"04","project":[{"name":"Tracing Evolution of Auxin Transport and Polarity in Plants","_id":"261099A6-B435-11E9-9278-68D0E5697425","grant_number":"742985","call_identifier":"H2020"},{"name":"RNA-directed DNA methylation in plant development","_id":"262EF96E-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","grant_number":"P29988"}],"article_processing_charge":"Yes (in subscription journal)","abstract":[{"lang":"eng","text":"The plant-signaling molecule auxin triggers fast and slow cellular responses across land plants and algae. The nuclear auxin pathway mediates gene expression and controls growth and development in land plants, but this pathway is absent from algal sister groups. Several components of rapid responses have been identified in Arabidopsis, but it is unknown if these are part of a conserved mechanism. We recently identified a fast, proteome-wide phosphorylation response to auxin. Here, we show that this response occurs across 5 land plant and algal species and converges on a core group of shared targets. We found conserved rapid physiological responses to auxin in the same species and identified rapidly accelerated fibrosarcoma (RAF)-like protein kinases as central mediators of auxin-triggered phosphorylation across species. Genetic analysis connects this kinase to both auxin-triggered protein phosphorylation and rapid cellular response, thus identifying an ancient mechanism for fast auxin responses in the green lineage."}],"doi":"10.1016/j.cell.2023.11.021","ddc":["580"],"ec_funded":1,"date_updated":"2026-04-07T11:48:32Z","has_accepted_license":"1","month":"01","acknowledgement":"We are grateful to Asuka Shitaku and Eri Koide for generating and sharing the Marchantia PRAF-mCitrine line and Peng-Cheng Wang for sharing the Arabidopsis raf mutant. We are grateful to our team members for discussions and helpful advice. This work was supported by funding from the Netherlands Organization for Scientific Research (NWO): VICI grant 865.14.001 and ENW-KLEIN OCENW.KLEIN.027 grants to D.W.; VENI grant VI.VENI.212.003 to A.K.; the European Research Council AdG DIRNDL (contract number 833867) to D.W.; CoG CATCH to J.S.; StG CELLONGATE (contract 803048) to M.F.; and AdG ETAP (contract 742985) to J.F.; MEXT KAKENHI grant number JP19H05675 to T.K.; JSPS KAKENHI grant number JP20H03275 to R.N.; Takeda Science Foundation to R.N.; and the Austrian Science Fund (FWF, P29988) to J.F.","oa":1,"article_type":"original","oa_version":"Published Version","file_date_updated":"2024-01-22T13:41:41Z","keyword":["General Biochemistry","Genetics and Molecular Biology"]},{"day":"08","_id":"14828","publication_status":"published","publisher":"American Chemical Society","external_id":{"isi":["001138342900001"]},"author":[{"last_name":"Kiran","first_name":"Gundegowda Kalligowdanadoddi","full_name":"Kiran, Gundegowda Kalligowdanadoddi"},{"first_name":"Saurabh","full_name":"Singh, Saurabh","orcid":"0000-0003-2209-5269","id":"12d625da-9cb3-11ed-9667-af09d37d3f0a","last_name":"Singh"},{"first_name":"Neelima","full_name":"Mahato, Neelima","last_name":"Mahato"},{"full_name":"Sreekanth, Thupakula Venkata Madhukar","first_name":"Thupakula Venkata Madhukar","last_name":"Sreekanth"},{"first_name":"Gowra Raghupathy","full_name":"Dillip, Gowra Raghupathy","last_name":"Dillip"},{"first_name":"Kisoo","full_name":"Yoo, Kisoo","last_name":"Yoo"},{"last_name":"Kim","full_name":"Kim, Jonghoon","first_name":"Jonghoon"}],"doi":"10.1021/acsaem.3c02519","abstract":[{"lang":"eng","text":"Production of hydrogen at large scale requires development of non-noble, inexpensive, and high-performing catalysts for constructing water-splitting devices. Herein, we report the synthesis of Zn-doped NiO heterostructure (ZnNiO) catalysts at room temperature via a coprecipitation method followed by drying (at 80 °C, 6 h) and calcination at an elevated temperature of 400 °C for 5 h under three distinct conditions, namely, air, N2, and vacuum. The vacuum-synthesized catalyst demonstrates a low overpotential of 88 mV at −10 mA cm–2 and a small Tafel slope of 73 mV dec–1 suggesting relatively higher charge transfer kinetics for hydrogen evolution reactions (HER) compared with the specimens synthesized under N2 or O2 atmosphere. It also demonstrates an oxygen evolution (OER) overpotential of 260 mV at 10 mA cm–2 with a low Tafel slope of 63 mV dec–1. In a full-cell water-splitting device, the vacuum-synthesized ZnNiO heterostructure demonstrates a cell voltage of 1.94 V at 50 mA cm–2 and shows remarkable stability over 24 h at a high current density of 100 mA cm–2. It is also demonstrated in this study that Zn-doping, surface, and interface engineering in transition-metal oxides play a crucial role in efficient electrocatalytic water splitting. Also, the results obtained from density functional theory (DFT + U = 0–8 eV), where U is the on-site Coulomb repulsion parameter also known as Hubbard U, based electronic structure calculations confirm that Zn doping constructively modifies the electronic structure, in both the valence band and the conduction band, and found to be suitable in tailoring the carrier’s effective masses of electrons and holes. The decrease in electron’s effective masses together with large differences between the effective masses of electrons and holes is noticed, which is found to be mainly responsible for achieving the best water-splitting performance from a 9% Zn-doped NiO sample prepared under vacuum."}],"article_processing_charge":"No","article_type":"original","keyword":["Electrical and Electronic Engineering","Materials Chemistry","Electrochemistry","Energy Engineering and Power Technology","Chemical Engineering (miscellaneous)"],"oa_version":"None","month":"01","date_updated":"2024-10-09T21:07:53Z","acknowledgement":"This work was supported by the Technology Innovation Program (20011622, Development of Battery System Applied High-Efficiency Heat Control Polymer and Part Component) funded by the Ministry of Trade, Industry & Energy (MOTIE, Korea). Author acknowledge to Prof. Tsunehiro Takeuchi from Toyota Technological Institute, Nagoya, Japan for the support of computational resources.","type":"journal_article","issue":"1","year":"2024","corr_author":"1","publication":"ACS Applied Energy Materials","title":"Interface engineering modulation combined with electronic structure modification of Zn-doped NiO heterostructure for efficient water-splitting activity","language":[{"iso":"eng"}],"scopus_import":"1","quality_controlled":"1","date_created":"2024-01-17T12:48:35Z","status":"public","volume":7,"citation":{"ama":"Kiran GK, Singh S, Mahato N, et al. Interface engineering modulation combined with electronic structure modification of Zn-doped NiO heterostructure for efficient water-splitting activity. ACS Applied Energy Materials. 2024;7(1):214-229. doi:10.1021/acsaem.3c02519","mla":"Kiran, Gundegowda Kalligowdanadoddi, et al. “Interface Engineering Modulation Combined with Electronic Structure Modification of Zn-Doped NiO Heterostructure for Efficient Water-Splitting Activity.” ACS Applied Energy Materials, vol. 7, no. 1, American Chemical Society, 2024, pp. 214–29, doi:10.1021/acsaem.3c02519.","short":"G.K. Kiran, S. Singh, N. Mahato, T.V.M. Sreekanth, G.R. Dillip, K. Yoo, J. Kim, ACS Applied Energy Materials 7 (2024) 214–229.","ista":"Kiran GK, Singh S, Mahato N, Sreekanth TVM, Dillip GR, Yoo K, Kim J. 2024. Interface engineering modulation combined with electronic structure modification of Zn-doped NiO heterostructure for efficient water-splitting activity. ACS Applied Energy Materials. 7(1), 214–229.","chicago":"Kiran, Gundegowda Kalligowdanadoddi, Saurabh Singh, Neelima Mahato, Thupakula Venkata Madhukar Sreekanth, Gowra Raghupathy Dillip, Kisoo Yoo, and Jonghoon Kim. “Interface Engineering Modulation Combined with Electronic Structure Modification of Zn-Doped NiO Heterostructure for Efficient Water-Splitting Activity.” ACS Applied Energy Materials. American Chemical Society, 2024. https://doi.org/10.1021/acsaem.3c02519.","ieee":"G. K. Kiran et al., “Interface engineering modulation combined with electronic structure modification of Zn-doped NiO heterostructure for efficient water-splitting activity,” ACS Applied Energy Materials, vol. 7, no. 1. American Chemical Society, pp. 214–229, 2024.","apa":"Kiran, G. K., Singh, S., Mahato, N., Sreekanth, T. V. M., Dillip, G. R., Yoo, K., & Kim, J. (2024). Interface engineering modulation combined with electronic structure modification of Zn-doped NiO heterostructure for efficient water-splitting activity. ACS Applied Energy Materials. American Chemical Society. https://doi.org/10.1021/acsaem.3c02519"},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","isi":1,"department":[{"_id":"MaIb"}],"publication_identifier":{"issn":["2574-0962"]},"intvolume":" 7","date_published":"2024-01-08T00:00:00Z","page":"214-229"},{"intvolume":" 103","date_published":"2024-03-01T00:00:00Z","article_number":"151380","isi":1,"department":[{"_id":"MaLo"}],"publication_identifier":{"issn":["0171-9335"]},"quality_controlled":"1","scopus_import":"1","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"date_created":"2024-01-18T08:16:43Z","status":"public","volume":103,"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","citation":{"ieee":"P. Radler and M. Loose, “A dynamic duo: Understanding the roles of FtsZ and FtsA for Escherichia coli cell division through in vitro approaches,” European Journal of Cell Biology, vol. 103, no. 1. Elsevier, 2024.","apa":"Radler, P., & Loose, M. (2024). A dynamic duo: Understanding the roles of FtsZ and FtsA for Escherichia coli cell division through in vitro approaches. European Journal of Cell Biology. Elsevier. https://doi.org/10.1016/j.ejcb.2023.151380","chicago":"Radler, Philipp, and Martin Loose. “A Dynamic Duo: Understanding the Roles of FtsZ and FtsA for Escherichia Coli Cell Division through in Vitro Approaches.” European Journal of Cell Biology. Elsevier, 2024. https://doi.org/10.1016/j.ejcb.2023.151380.","ista":"Radler P, Loose M. 2024. A dynamic duo: Understanding the roles of FtsZ and FtsA for Escherichia coli cell division through in vitro approaches. European Journal of Cell Biology. 103(1), 151380.","short":"P. Radler, M. Loose, European Journal of Cell Biology 103 (2024).","ama":"Radler P, Loose M. A dynamic duo: Understanding the roles of FtsZ and FtsA for Escherichia coli cell division through in vitro approaches. European Journal of Cell Biology. 2024;103(1). doi:10.1016/j.ejcb.2023.151380","mla":"Radler, Philipp, and Martin Loose. “A Dynamic Duo: Understanding the Roles of FtsZ and FtsA for Escherichia Coli Cell Division through in Vitro Approaches.” European Journal of Cell Biology, vol. 103, no. 1, 151380, Elsevier, 2024, doi:10.1016/j.ejcb.2023.151380."},"pmid":1,"issue":"1","year":"2024","type":"journal_article","publication":"European Journal of Cell Biology","corr_author":"1","title":"A dynamic duo: Understanding the roles of FtsZ and FtsA for Escherichia coli cell division through in vitro approaches","file":[{"creator":"dernst","success":1,"file_id":"17265","access_level":"open_access","content_type":"application/pdf","date_created":"2024-07-16T12:07:20Z","date_updated":"2024-07-16T12:07:20Z","file_name":"2024_EJCB_Radler.pdf","checksum":"5d170abbc87585205c010657e4552360","file_size":9995304,"relation":"main_file"}],"language":[{"iso":"eng"}],"month":"03","has_accepted_license":"1","date_updated":"2025-09-04T11:45:31Z","acknowledgement":"We acknowledge members of the Loose laboratory at ISTA for helpful discussions—in particular M. Kojic for his insightful comments. This work was supported by the Austrian Science Fund (FWF P34607) to M.L.","oa":1,"article_type":"review","oa_version":"Published Version","file_date_updated":"2024-07-16T12:07:20Z","keyword":["Cell Biology","General Medicine","Histology","Pathology and Forensic Medicine"],"project":[{"grant_number":"P34607","name":"In vitro reconstitution of bacterial cell division","_id":"fc38323b-9c52-11eb-aca3-ff8afb4a011d"}],"day":"01","publication_status":"published","_id":"14834","external_id":{"pmid":["38218128"],"isi":["001166216800001"]},"publisher":"Elsevier","author":[{"full_name":"Radler, Philipp","orcid":"0000-0001-9198-2182 ","first_name":"Philipp","id":"40136C2A-F248-11E8-B48F-1D18A9856A87","last_name":"Radler"},{"last_name":"Loose","id":"462D4284-F248-11E8-B48F-1D18A9856A87","first_name":"Martin","orcid":"0000-0001-7309-9724","full_name":"Loose, Martin"}],"doi":"10.1016/j.ejcb.2023.151380","abstract":[{"lang":"eng","text":"Bacteria divide by binary fission. The protein machine responsible for this process is the divisome, a transient assembly of more than 30 proteins in and on the surface of the cytoplasmic membrane. Together, they constrict the cell envelope and remodel the peptidoglycan layer to eventually split the cell into two. For Escherichia coli, most molecular players involved in this process have probably been identified, but obtaining the quantitative information needed for a mechanistic understanding can often not be achieved from experiments in vivo alone. Since the discovery of the Z-ring more than 30 years ago, in vitro reconstitution experiments have been crucial to shed light on molecular processes normally hidden in the complex environment of the living cell. In this review, we summarize how rebuilding the divisome from purified components – or at least parts of it - have been instrumental to obtain the detailed mechanistic understanding of the bacterial cell division machinery that we have today."}],"article_processing_charge":"Yes","ddc":["570"]},{"department":[{"_id":"TiVo"}],"publication_identifier":{"eissn":["1091-6490"]},"isi":1,"OA_place":"publisher","intvolume":" 121","article_number":"e2307776121","date_published":"2024-01-16T00:00:00Z","pmid":1,"type":"journal_article","year":"2024","issue":"3","title":"A structurally precise mechanism links an epilepsy-associated KCNC2 potassium channel mutation to interneuron dysfunction","publication":"Proceedings of the National Academy of Sciences of the United States of America","language":[{"iso":"eng"}],"file":[{"file_name":"2024_PNAS_Clatot.pdf","checksum":"f498c643be81895dd3a69ee90115a782","relation":"main_file","file_size":3060109,"content_type":"application/pdf","date_created":"2025-04-23T13:51:16Z","date_updated":"2025-04-23T13:51:16Z","success":1,"access_level":"open_access","file_id":"19613","creator":"dernst"}],"related_material":{"link":[{"url":"https://github.com/ChrisCurrin/pv-kcnc2 ","relation":"software"}]},"scopus_import":"1","quality_controlled":"1","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","short":"CC BY-NC-ND (4.0)","image":"/images/cc_by_nc_nd.png","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)"},"date_created":"2024-01-21T23:00:56Z","volume":121,"status":"public","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","citation":{"ieee":"J. Clatot et al., “A structurally precise mechanism links an epilepsy-associated KCNC2 potassium channel mutation to interneuron dysfunction,” Proceedings of the National Academy of Sciences of the United States of America, vol. 121, no. 3. National Academy of Sciences, 2024.","apa":"Clatot, J., Currin, C., Liang, Q., Pipatpolkai, T., Massey, S. L., Helbig, I., … Goldberg, E. M. (2024). A structurally precise mechanism links an epilepsy-associated KCNC2 potassium channel mutation to interneuron dysfunction. Proceedings of the National Academy of Sciences of the United States of America. National Academy of Sciences. https://doi.org/10.1073/pnas.2307776121","chicago":"Clatot, Jerome, Christopher Currin, Qiansheng Liang, Tanadet Pipatpolkai, Shavonne L. Massey, Ingo Helbig, Lucie Delemotte, Tim P Vogels, Manuel Covarrubias, and Ethan M. Goldberg. “A Structurally Precise Mechanism Links an Epilepsy-Associated KCNC2 Potassium Channel Mutation to Interneuron Dysfunction.” Proceedings of the National Academy of Sciences of the United States of America. National Academy of Sciences, 2024. https://doi.org/10.1073/pnas.2307776121.","ista":"Clatot J, Currin C, Liang Q, Pipatpolkai T, Massey SL, Helbig I, Delemotte L, Vogels TP, Covarrubias M, Goldberg EM. 2024. A structurally precise mechanism links an epilepsy-associated KCNC2 potassium channel mutation to interneuron dysfunction. Proceedings of the National Academy of Sciences of the United States of America. 121(3), e2307776121.","short":"J. Clatot, C. Currin, Q. Liang, T. Pipatpolkai, S.L. Massey, I. Helbig, L. Delemotte, T.P. Vogels, M. Covarrubias, E.M. Goldberg, Proceedings of the National Academy of Sciences of the United States of America 121 (2024).","ama":"Clatot J, Currin C, Liang Q, et al. A structurally precise mechanism links an epilepsy-associated KCNC2 potassium channel mutation to interneuron dysfunction. Proceedings of the National Academy of Sciences of the United States of America. 2024;121(3). doi:10.1073/pnas.2307776121","mla":"Clatot, Jerome, et al. “A Structurally Precise Mechanism Links an Epilepsy-Associated KCNC2 Potassium Channel Mutation to Interneuron Dysfunction.” Proceedings of the National Academy of Sciences of the United States of America, vol. 121, no. 3, e2307776121, National Academy of Sciences, 2024, doi:10.1073/pnas.2307776121."},"oa":1,"article_type":"original","file_date_updated":"2025-04-23T13:51:16Z","oa_version":"Published Version","month":"01","date_updated":"2025-09-04T11:47:47Z","has_accepted_license":"1","acknowledgement":"This work was supported by an ERC Consolidator Grant (SYNAPSEEK) to T.P.V., the NOMIS Foundation through the NOMIS Fellowships program at IST Austria to C.B.C., a Jefferson Synaptic Biology Center Pilot Project Grant to M.C., NIH NINDS U54 NS108874 (PI, Alfred L. George), and NIH NINDS R01 NS122887 to E.M.G. The computations were enabled by resources provided by the Swedish National Infrastructure for Computing (SNIC) at the PDC Center for High-Performance Computing, KTH Royal Institute of Technology, partially funded by the Swedish Research Council through grant agreement no. 2018-05973. We thank Akshay Sridhar for the fruitful discussion of the project.","OA_type":"hybrid","ddc":["570"],"ec_funded":1,"day":"16","project":[{"grant_number":"819603","call_identifier":"H2020","_id":"0aacfa84-070f-11eb-9043-d7eb2c709234","name":"Learning the shape of synaptic plasticity rules for neuronal architectures and function through machine learning."}],"publisher":"National Academy of Sciences","_id":"14841","external_id":{"isi":["001167401000001"],"pmid":["38194456"]},"author":[{"full_name":"Clatot, Jerome","first_name":"Jerome","last_name":"Clatot"},{"orcid":"0000-0002-4809-5059","full_name":"Currin, Christopher","first_name":"Christopher","last_name":"Currin","id":"e8321fc5-3091-11eb-8a53-83f309a11ac9"},{"first_name":"Qiansheng","full_name":"Liang, Qiansheng","last_name":"Liang"},{"full_name":"Pipatpolkai, Tanadet","first_name":"Tanadet","last_name":"Pipatpolkai"},{"full_name":"Massey, Shavonne L.","first_name":"Shavonne L.","last_name":"Massey"},{"full_name":"Helbig, Ingo","first_name":"Ingo","last_name":"Helbig"},{"last_name":"Delemotte","first_name":"Lucie","full_name":"Delemotte, Lucie"},{"orcid":"0000-0003-3295-6181","full_name":"Vogels, Tim P","first_name":"Tim P","last_name":"Vogels","id":"CB6FF8D2-008F-11EA-8E08-2637E6697425"},{"full_name":"Covarrubias, Manuel","first_name":"Manuel","last_name":"Covarrubias"},{"last_name":"Goldberg","first_name":"Ethan M.","full_name":"Goldberg, Ethan M."}],"publication_status":"published","article_processing_charge":"Yes (in subscription journal)","abstract":[{"lang":"eng","text":"De novo heterozygous variants in KCNC2 encoding the voltage-gated potassium (K+) channel subunit Kv3.2 are a recently described cause of developmental and epileptic encephalopathy (DEE). A de novo variant in KCNC2 c.374G > A (p.Cys125Tyr) was identified via exome sequencing in a patient with DEE. Relative to wild-type Kv3.2, Kv3.2-p.Cys125Tyr induces K+ currents exhibiting a large hyperpolarizing shift in the voltage dependence of activation, accelerated activation, and delayed deactivation consistent with a relative stabilization of the open conformation, along with increased current density. Leveraging the cryogenic electron microscopy (cryo-EM) structure of Kv3.1, molecular dynamic simulations suggest that a strong π-π stacking interaction between the variant Tyr125 and Tyr156 in the α-6 helix of the T1 domain promotes a relative stabilization of the open conformation of the channel, which underlies the observed gain of function. A multicompartment computational model of a Kv3-expressing parvalbumin-positive cerebral cortex fast-spiking γ-aminobutyric acidergic (GABAergic) interneuron (PV-IN) demonstrates how the Kv3.2-Cys125Tyr variant impairs neuronal excitability and dysregulates inhibition in cerebral cortex circuits to explain the resulting epilepsy."}],"doi":"10.1073/pnas.2307776121"},{"pmid":1,"type":"other_academic_publication","issue":"1","year":"2024","publication":"Current Biology","corr_author":"1","title":"Eva Benkova","language":[{"iso":"eng"}],"quality_controlled":"1","date_created":"2024-01-21T23:00:56Z","status":"public","volume":34,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"chicago":"Benková, Eva. Eva Benkova. Current Biology. Vol. 34. Elsevier, 2024. https://doi.org/10.1016/j.cub.2023.11.039.","ieee":"E. Benková, Eva Benkova, vol. 34, no. 1. Elsevier, 2024, pp. R3–R5.","apa":"Benková, E. (2024). Eva Benkova. Current Biology (Vol. 34, pp. R3–R5). Elsevier. https://doi.org/10.1016/j.cub.2023.11.039","ama":"Benková E. Eva Benkova. Vol 34. Elsevier; 2024:R3-R5. doi:10.1016/j.cub.2023.11.039","mla":"Benková, Eva. “Eva Benkova.” Current Biology, vol. 34, no. 1, Elsevier, 2024, pp. R3–5, doi:10.1016/j.cub.2023.11.039.","short":"E. Benková, Eva Benkova, Elsevier, 2024.","ista":"Benková E. 2024. Eva Benkova, Elsevier,p."},"publication_identifier":{"eissn":["1879-0445"]},"department":[{"_id":"EvBe"}],"intvolume":" 34","date_published":"2024-01-08T00:00:00Z","page":"R3-R5","ddc":["580"],"day":"08","external_id":{"pmid":["38194926"]},"_id":"14842","publication_status":"published","author":[{"full_name":"Benková, Eva","orcid":"0000-0002-8510-9739","first_name":"Eva","id":"38F4F166-F248-11E8-B48F-1D18A9856A87","last_name":"Benková"}],"publisher":"Elsevier","doi":"10.1016/j.cub.2023.11.039","article_processing_charge":"No","abstract":[{"lang":"eng","text":"Eva Benkova received a PhD in Biophysics at the Institute of Biophysics of the Czech Academy of Sciences in 1998. After working as a postdoc at the Max Planck Institute in Cologne and the Center for Plant Molecular Biology (ZMBP) in Tübingen, she became a group leader at the Plant Systems Biology Department of the Vlaams Instituut voor Biotechnologie (VIB) in Gent. In 2012, she transitioned to an Assistant Professor position at the Institute of Science and Technology Austria (ISTA) where she was later promoted to Professor. Since 2021, she has served as the Dean of the ISTA Graduate School. As a plant developmental biologist, she focuses on unraveling the molecular mechanisms and principles that underlie hormonal interactions in plants. In her current work, she explores the intricate connections between hormones and regulatory pathways that mediate the perception of environmental stimuli, including abiotic stress and nitrate availability."}],"oa":1,"oa_version":"Published Version","month":"01","date_updated":"2026-06-18T17:40:39Z","main_file_link":[{"url":"https://doi.org/10.1016/j.cub.2023.11.039","open_access":"1"}]}]