@article{20866, abstract = {In this work, we present hypernode automata as a specification formalism for hyperproperties of systems whose executions may be misaligned among themselves, such as concurrent systems. These automata consist of nodes labeled with hypernode logic formulas and transitions marked with synchronizing actions. Hypernode logic formulas establish relations between sequences of variable values among different system executions. This logic enables both synchronous and asynchronous analysis of traces. In its asynchronous view on execution traces, hypernode formulas establish relations on the order of value changes for each variable without correlating their timing. In both views, the analysis of different execution traces is synchronized through the transitions of hypernode automata. By combining logic’s declarative nature with automata’s procedural power, hypernode automata seamlessly integrate asynchronicity requirements at the node level with synchronicity between node transitions. We show that the model-checking problem for hypernode automata is decidable for specifications where each node specifies either a synchronous or an asynchronous requirement for the system’s executions, but not both.}, author = {Bartocci, Ezio and Chalupa, Marek and Henzinger, Thomas A and Nickovic, Dejan and Oliveira da Costa, Ana}, issn = {1432-0525}, journal = {Acta Informatica}, number = {4}, publisher = {Springer Nature}, title = {{Hypernode automata}}, doi = {10.1007/s00236-025-00509-8}, volume = {62}, year = {2025}, } @article{20867, abstract = {We discuss the embeddability of subspaces of the Gromov–Hausdorff space, which consists of isometry classes of compact metric spaces endowed with the Gromov–Hausdorff distance, into Hilbert spaces. These embeddings are particularly valuable for applications to topological data analysis. We prove that its subspace consisting of metric spaces with at most n points has asymptotic dimension n(n−1)∕2. Thus, there exists a coarse embedding of that space into a Hilbert space. On the contrary, if the number of points is not bounded, then the subspace cannot be coarsely embedded into any uniformly convex Banach space and so, in particular, into any Hilbert space. Furthermore, we prove that, even if we restrict to finite metric spaces whose diameter is bounded by some constant, the subspace still cannot be bi-Lipschitz embedded into any finite-dimensional Hilbert space. We obtain both nonembeddability results by finding obstructions to coarse and bi-Lipschitz embeddings in families of isometry classes of finite subsets of the real line endowed with the Euclidean–Hausdorff distance.}, author = {Zava, Nicolò}, issn = {1472-2739}, journal = {Algebraic & Geometric Topology}, number = {8}, pages = {5153--5174}, publisher = {Mathematical Sciences Publishers}, title = {{Coarse and bi-Lipschitz embeddability of subspaces of the Gromov–Hausdorff space into Hilbert spaces}}, doi = {10.2140/agt.2025.25.5153}, volume = {25}, year = {2025}, } @article{20868, abstract = {Residents of low-latitude megacities face growing vulnerability to humid-heat stress under urbanization and global warming, yet limited research has assessed the morbidity burden of mental and behavioral disorders (MBDs) linked to humid-heat exposures in these cities. Here we quantify the hospital admissions of MBDs in Shanghai, a megacity of over 25 million inhabitants, attributable to humid heat, and project future burdens under various greenhouse gas (GHG)-emission and population scenarios. Humid heat drives a higher morbidity burden than high temperature alone, especially in humid-heat nights. Without population change, the humid-heat-related morbidity burden of MBDs would increase by 68.2% (95% empirical confidence interval 56.7%–81.6%) under the highest-GHG-emission scenario by the 2090s, while 8,465 (95% empirical confidence interval 6,928–10,053) cases would be avoided by reducing emissions to the lowest pathway. With projected population decline, the attributable hospital admissions will decrease toward century’s end. These findings highlight the benefit of GHG mitigation in reducing the growing MBD risks posed by extreme humid heat.}, author = {Liang, Chen and Yuan, Jiacan and Zhang, Renhe and Tang, Xu and Schumann, Gunter and Hitchen, Esther and Polemiti, Elli and Serin, Emin and Kebir, Hedi and Lett, Tristram A. and Vaidya, Nilakshi and Roy, Jean-Charles and Walter, Henrik and Heinz, Andreas and Ralser, Markus and Twardziok, Sven and Eils, Roland and Jentsch, Marcel and Taron, Ulrike-Helene and Schütz, Tatjana and Schepanski, Kerstin and Banaschewski, Tobias and Neidhart, Maja and Meyer-Lindenberg, Andreas and Tost, Heike and Holz, Nathalie and Schwarz, Emanuel and Stringaris, Argyris and Christmann, Nina and Janson, Karina and Nees, Frauke and Neidhart, Maja and Seefried, Beke and Aden, Rieke and Andreassen, Ole A. and Westlye, Lars T. and van der Meer, Dennis and Fernández-Cabello, Sara and Kjelkenes, Rikka and Ask, Helga and Rapp, Michael and Tschorn, Mira and Böttger, Sarah Jane and Marquand, Andre and Bernas, Antoine and Novarino, Gaia and Slater, Mel and Gallego, Jaime and Pastor, Álvaro and Feixas, Guillem and Eiroa-Orosa, Francisco José and Nöthen, Markus M. and Forstner, Andreas J. and Claus, Isabelle and Mathey, Carina and Heilmann-Heimbach, Stefanie and Hoffmann, Per and Miller, Abigail and Sommer, Peter and Schmitt, Karen and Wilbertz, Johannes and Patraskaki, Myrto and Jirsa, Viktor and Petkoski, Spase and Athanasiadis, Anastasios-Polykarpos and Spanlang, Bernhard and Pearmund, Charlie and Hese, Sören and Renner, Paul and Jia, Tianye and Chang, Xiao and Dai, Yuxiang and Xia, Yunman and Li, Yuzhu and Zhang, Yanqing and Calhoun, Vince and Thompson, Paul and Clinton, Nicholas and Desrivières, Sylvane and Agunbiade, Kofoworola and Yu, Xinyang and Zhang, Zuo and Chen, Di and Young, Allan H. and Schwalber, Ameli and Köhler, Vanessa and Stahl, Bernd and Ogoh, George and Schikowski, Tamara and Brandlistuen, Ragnhild}, issn = {2731-6076}, journal = {Nature Mental Health}, number = {12}, pages = {1532--1544}, publisher = {Springer Nature}, title = {{Projecting the morbidity burden of mental and behavioral disorders associated with increasing humid heat in Shanghai}}, doi = {10.1038/s44220-025-00519-y}, volume = {3}, year = {2025}, } @article{20869, abstract = {Premise: What maintains trait divergence in the face of gene flow? Two varieties of wild snapdragon (Antirrhinum majus) characterized by divergent flower color hybridize in their native range. Selection on flower color genes is indicated by sharp clines, but the selective agents have not been demonstrated. Although previous work has focused on pollinators, pigmentation genes can also contribute to abiotic stress tolerance. We hypothesized that pigmentation in A. majus mediates stress tolerance, which could contribute to hybrid zone maintenance through parental niche divergence or hybrid maladaptation. Specifically, we tested whether morphotype mediates drought tolerance in an experiment comparing magenta-flowered var. pseudomajus, yellow-flowered var. striatum, and their pink-flowered hybrid cross. Methods: We experimentally compared drought tolerance of each morphotype from allopatric crosses within and between varieties using three greenhouse treatments. Control plants were watered as needed, while drought-treated plants were watered half as often, either from the transplant stage (“early” drought), or from flowering onset (“late” drought). Results: Parental morphotypes responded identically to drought in fitness and most phenotypic traits. However, hybrids had lower survival (14%) under late drought stress than parental morphotypes (70%). All hybrids that flowered in the late drought treatment died, compared to ~20% of flowering parental morphotypes. Conclusions: Hybrid maladaptation to abiotic stress could potentially contribute to flower color divergence in the face of gene flow in A. majus. Further research should test the relevance of our results to field conditions and explicitly probe the role of flower color genes in drought tolerance.}, author = {Fuster‐Calvo, Alexandre and Jaworski, Coline C. and Ellis, Thomas and Baskett, Carina}, issn = {1537-2197}, journal = {American Journal of Botany}, number = {12}, publisher = {Wiley}, title = {{Reduced fitness under drought stress in F1 hybrids of Antirrhinum majus varieties with divergent flower colors}}, doi = {10.1002/ajb2.70129}, volume = {112}, year = {2025}, } @inbook{20870, abstract = {RNA sequencing (RNA-seq) methodologies have evolved rapidly, offering powerful tools to study gene expression, transcriptome dynamics, and molecular mechanisms in various biological contexts. However, the complexity of these approaches poses challenges in data interpretation, sensitivity, and applicability. This chapter provides a comprehensive overview of RNA-seq methodologies, highlighting their advantages, limitations, and applications, particularly in cardiovascular research. Bulk RNA sequencing enables high-throughput gene expression profiling but lacks the resolution to capture cellular heterogeneity and spatial context. Direct RNA sequencing preserves native RNA modifications, offering insights into post-transcriptional regulation, though it remains technically challenging. Single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) bridge these gaps by resolving transcriptomic complexity at the cellular level and within tissue architecture, providing crucial insights into disease mechanisms such as atherosclerosis. By summarizing the strengths and limitations of these methodologies, this chapter aims to guide researchers in selecting the most suitable transcriptomic approach for their studies, ultimately advancing precision medicine and biomarker discovery in cardiovascular disease.}, author = {Stopa, Victoria and Sopić, Miron and Li, Guanliang and Sluimer, Judith and Basílio, José and van der Laan, Sander W. and Kreil, David P. and Devaux, Yvan and Hochreiter, Bernhard}, booktitle = {Transcriptomics in Atherosclerosis}, editor = {Devaux, Yvan and Sopic, Miron}, isbn = {9780443330643}, pages = {131--172}, publisher = {Elsevier}, title = {{Essentials of transcriptomic methods: Navigating through RNA sequencing and beyond}}, doi = {10.1016/b978-0-443-33064-3.00016-5}, year = {2025}, } @misc{20883, abstract = {Evading imminent predator threat is critical for survival. Effective defensive strategies can vary, even between closely related species. However, the neural basis of such species-specific behaviours is still poorly understood. Here we find that two sister species of deer mice (genus Peromyscus) show different responses to the same looming stimulus: P. maniculatus, which occupies densely vegetated habitats, predominantly escapes, while the open field specialist, P. polionotus, briefly freezes. This difference arises from species-specific escape thresholds, is largely context-independent, and can be triggered by both visual and auditory threat stimuli. Using immunohistochemistry and electrophysiological recordings, we find that although visual threat activates the superior colliculus in both species, the role of the dorsal periaqueductal gray (dPAG) in driving behaviour differs. While dPAG activity scales with running speed in P. maniculatus, neural activity in the dPAG of P. polionotus correlates poorly with movement, including during visually triggered escape. Moreover, optogenetic activation of dPAG neurons elicits acceleration in P. maniculatus but not P. polionotus, while their chemogenetic inhibition during a looming stimulus delays escape onset in P. maniculatus to match that of P. polionotus. Together, we trace species-specific escape thresholds to a central circuit node, downstream of peripheral sensory neurons, localizing an ecologically relevant behavioural difference to a specific region of the mammalian brain.}, author = {Felix, Baier and Reinhard, Katja and Nuttin, Bram and Sans Dublanc, Arnau and Liu, Chen and Tong, Victoria and Murmann, Julie Stefanie and Wierda, Keimpe and Farrow, Karl and Hoekstra, Hopi}, publisher = {Dryad}, title = {{The neural basis of species-specific defensive behaviour in Peromyscus mice}}, doi = {10.5061/DRYAD.Q2BVQ83XC}, year = {2025}, } @phdthesis{20920, abstract = {Verifiable Delay Functions (VDFs) introduced by Boneh et al. (CRYPTO'18) are functions that require a prescribed number of sequential steps T to evaluate, yet their output can be verified in time much faster than T. Since their introduction, VDFs have gained a lot of attention due to their applications in blockchain protocols, randomness beacons, timestamping and deniability. This thesis explores the theory and applications of VDFs, focusing on enhancing their soundness, efficiency and practicality. The only practical VDFs known to date are based on repeated squaring in hidden order groups. Consider the function VDF(x,T)=x^(2^T). The iterated squaring assumption states that, for a random group element x, the result of VDF cannot be computed significantly faster than performing T sequential squarings if the group order is unknown. To make the result verifiable a prover can compute a proof of exponentiation (PoE) \pi. Given \pi, the output of VDF can be verified in time much less than T. We first present new constructions of statistically sound proofs of exponentiation, which are an important building block in the construction of SNARKs (Succinct Non-Interactive Argument of Knowledge). Statistical soundness means that the proofs remain secure against computationally unbounded adversaries, in particular, it remains secure even when the group order is known. We thereby address limitations in previous PoE protocols which either required (non-standard) hardness assumptions or a lot of parallel repetitions. Our construction significantly reduces the proof size of statistically sound PoEs that allow for a structured exponent, which leads to better efficiency of SNARKs and other applications. Secondly, we introduce improved batching techniques for PoEs, which allow multiple proofs to be aggregated and verified with minimal overhead. These protocols optimize communication and computation complexity in large-scale blockchain environments and enable scalable remote benchmarking of parallel computation resources. We then construct VDFs with enhanced properties such as zero-knowledge and watermarkability. It was shown by Arun, Bonneau and Clark (ASIACRYPT'22) that these features enable new cryptographic primitives called short-lived proofs and signatures. The validity of such proofs and signatures expires after a predefined amount of time T, i.e., they are deniable after time T. Our constructions improve upon the constructions by Arun, Bonneau and Clark in several dimensions (faster forging times, arguably weaker assumptions). Finally, we apply PoEs in the realm of primality testing, providing cryptographically sound proofs of non-primality for large Proth numbers. This work gives a surprising application of VDFs in the area of computational number theory. Together, our contributions advance both the theoretical foundations and the real-world usability of VDFs in general and in particular of PoEs, making them more adaptable and secure for current and emerging cryptographic applications.}, author = {Hoffmann, Charlotte}, issn = {2663-337X}, pages = {116}, publisher = {Institute of Science and Technology Austria}, title = {{Theory and applications of verifiable delay functions}}, doi = {10.15479/AT-ISTA-20920}, year = {2025}, } @article{20924, abstract = {Pioneer transcription factors (TFs) possess the ability to read out DNA motifs embedded within nucleosomes, driving changes in gene expression during cellular differentiation and reprogramming. Here, we present selected engagement on nucleosome sequencing (SeEN-seq), a protocol designed to systematically identify potential TF-binding sites on the nucleosome. We describe steps for nucleosome library assembly, SeEN-seq assay, and cryoelectron microscopy (cryo-EM) sample preparation. This protocol facilitates the preparation of homogeneous pioneer TF-nucleosome complexes for cryo-EM structure determination using single-particle analysis. For complete details on the use and execution of this protocol, please refer to Michael et al.1}, author = {Kobayashi, Wataru and Michael, Alicia and Ruangroengkulrith, Siwat and Kümmecke, Maximilian and Tachibana, Kikuë}, issn = {2666-1667}, journal = {STAR Protocols}, publisher = {Elsevier}, title = {{Protocol for integrative analysis of transcription factor-nucleosome interactions using SeEN-seq and cryo-EM structure determination}}, doi = {10.1016/j.xpro.2025.104295}, volume = {7}, year = {2025}, } @article{20925, abstract = {We prove normal typicality and dynamical typicality for a (centered) random block-band matrix model with block-dependent variances. A key feature of our model is that we achieve intermediate equilibration times, an aspect that has not been proven rigorously in any model before. Our proof builds on recently established concentration estimates for products of resolvents of Wigner type random matrices (Erdős and Riabov in Commun Math Phys 405(12): 282, 2024) and an intricate analysis of the deterministic approximation.}, author = {Erdös, László and Henheik, Sven Joscha and Vogel, Cornelia}, issn = {1573-0530}, journal = {Letters in Mathematical Physics}, publisher = {Springer Nature}, title = {{Normal typicality and dynamical typicality for a random block-band matrix model}}, doi = {10.1007/s11005-025-02037-5}, volume = {116}, year = {2025}, } @article{20926, abstract = {Most current machine learning interatomic potentials (MLIPs) rely on short-range approximations, without explicit treatment of long-range electrostatics. To address this, we recently developed the Latent Ewald Summation (LES) method, which infers electrostatic interactions, polarization, and Born effective charges (BECs), just by learning from energy and force training data. Here, we present LES as a standalone library, compatible with any short-range MLIP, and demonstrate its integration with methods such as MACE, NequIP, Allegro, CACE, CHGNet, and UMA. We benchmark LES-enhanced models on distinct systems, including bulk water, polar dipeptides, and gold dimer adsorption on defective substrates, and show that LES not only captures correct electrostatics but also improves accuracy. Additionally, we scale LES to large and chemically diverse data by training MACELES-OFF on the SPICE set containing molecules and clusters, making a universal MLIP with electrostatics for organic systems, including biomolecules. MACELES-OFF is more accurate than its short-range counterpart (MACE-OFF) trained on the same data set, predicts dipoles and BECs reliably, and has better descriptions of bulk liquids. By enabling efficient long-range electrostatics without directly training on electrical properties, LES paves the way for electrostatic foundation MLIPs.}, author = {Kim, Dongjin and Wang, Xiaoyu and Vargas, Santiago and Zhong, Peichen and King, Daniel S. and Inizan, Theo Jaffrelot and Cheng, Bingqing}, issn = {1549-9626}, journal = {Journal of Chemical Theory and Computation}, number = {24}, pages = {12709--12724}, publisher = {American Chemical Society}, title = {{A universal augmentation framework for long-range electrostatics in machine learning interatomic potentials}}, doi = {10.1021/acs.jctc.5c01400}, volume = {21}, year = {2025}, } @article{20927, abstract = {Cavity-magnon polaritons are hybrid excitations from the interaction between cavity photons and magnons, the quanta of collective spin oscillations. Along with the tunability of the magnon-photon coupling strength, fast information transfer and conversion speed are desired in hybrid devices. This can be achieved utilizing the propagating nature of spin waves with nonzero momentum for their ultrafast time dynamics and reduced ohmic dissipation. Antiferromagnets are particularly interesting as hosts for magnons since stray-field interactions are minimized and they support multiple modes with distinctive magnetic-field behavior across the phase diagram. Chromium trichloride (CrCl3) is a van der Waals layered antiferromagnet having a strong easy-plane anisotropy and a weak in-plane easy-axis anisotropy. Despite some magnetic resonance studies, the impact of magnetic reorientation of spins in CrCl3 on the cavity-magnon-polariton interaction strength as a function of magnetic field remains largely unexplored. In this study, we investigate the coupling between magnons in CrCl3 and photons in a coplanar waveguide resonator as a function of magnetic field. In particular, we find that the magnon-photon coupling strength varies nonmonotonically and distinctly with the magnetic field for the acoustic and the optical magnons, which can be utilized to tune the magnon-photon coupling strength using an external magnetic field as a knob. We find the signature of spin-flop transition in the two harmonics of the cavity due to a stronger dispersive coupling between optical magnons and cavity photons at lower fields. Additionally, we find standing modes formed by spin waves with nonzero momentum associated with the two hybrid magnons when the external field is applied at an angle with the crystal plane. These modes do not undergo substantial coupling with the cavity mode unlike the antiferromagnetic modes and can be used as low-loss propagation channels in hybrid devices.}, author = {Mandal, Supriya and Maji, Krishnendu and Kapoor, Lucky and Sasmal, Souvik and Manni, Soham and Jesudasan, John and Raychaudhuri, Pratap and Thamizhavel, Arumugam and Deshmukh, Mandar M.}, issn = {2469-9969}, journal = {Physical Review B}, number = {21}, publisher = {American Physical Society}, title = {{Cavity based sensing of antiferromagnetic canting and nonzero-momentum spin waves in a van der Waals cavity-magnon-polariton system}}, doi = {10.1103/bdd1-b8ys}, volume = {112}, year = {2025}, } @article{20928, abstract = {The current work focuses on the performance of hydrodynamics and mass transfer in a microchannel. A hydrodynamic model is developed for a gas–liquid (CO2–water) system and slug flow pattern. For the first time in literature, a concept of pulsating velocity input is introduced in an enhanced cross-T-junction microchannel to study the mass transfer using the physical absorption mechanism in ANSYS FLUENT R2 2024. The mass transfer model is associated with the hydrodynamic model and some user-defined functions in FLUENT. This work demonstrates that incorporating obstructions and applying trapezoidal and sinusoidal wave inputs improve the CO2 absorption rate. The obtained data are further compared with the plain T-junction microchannel in terms of mass transfer coefficient. Solubility of CO2 in three different solvents (ethyl alcohol, water, and ethylene glycol) has been revealed in an enhanced cross T-junction microchannel at two different temperatures, i.e., 298.15 and 303.15 K. The numerical simulations illustrate that an increase in temperature has an adverse effect on the mass transfer rate.}, author = {Khatoon, Bushra and Chaudhary, Vikas K. and Kamil, Shoaib and Hasan, Shabih Ul and Alam, M. Siraj}, issn = {1089-7666}, journal = {Physics of Fluids}, number = {12}, publisher = {AIP Publishing}, title = {{Enhanced mass transfer in microgeometry using pulsating velocity inputs: Hydrodynamic analysis and numerical simulation}}, doi = {10.1063/5.0303132}, volume = {37}, year = {2025}, } @article{20929, abstract = {Insulin/insulin-like growth factor signaling inhibits FOXO transcription factors to control development, homeostasis, and aging. Here, we use proximity labeling to identify proteins interacting with the C. elegans FOXO DAF-16. We show that in well-fed, unstressed animals harboring active insulin signaling, DAF-16 forms a complex with the PAR-1/MARK serine/threonine kinase, a key regulator of cell polarity. PAR-1 inhibits DAF-16 accumulation and promotes DAF-16 phosphorylation at S249, at a conserved motif that PAR-1/human MARK2 phosphorylates in vitro. DAF-2 insulin-like receptor signaling stimulates DAF-16 S249 phosphorylation, suggesting DAF-2 activates PAR-1. DAF-2 also promotes PAR-1 expression by inhibiting DAF-16. PAR-1 knockdown, or DAF-16 S249A, prolong lifespan, whereas phosphomimetic DAF-16 S249D suppresses the longevity of daf-2 mutants. At low insulin signaling, DAF-16 proximity labeling highlights transcription factors, chromatin regulators, and DNA repair proteins. One interactor, the zinc finger/homeobox protein ZFH-2/ZFHX3, forms a complex with DAF-16 and prolongs lifespan. Our work provides entry points for hypothesis-driven studies of FOXO function and longevity.}, author = {Artan, Murat and Schön, Hanna and De Bono, Mario}, issn = {2041-1723}, journal = {Nature Communications}, publisher = {Springer Nature}, title = {{Proximity labeling of DAF-16 FOXO highlights aging regulatory proteins}}, doi = {10.1038/s41467-025-66409-0}, volume = {16}, year = {2025}, } @article{20930, abstract = {Context. Beta Pictoris is an A-type star that hosts a complex planetary system with two massive gas giants and a prominent debris disc. Variable absorption lines in its stellar spectrum have been interpreted as signatures of exocomets – comet-like bodies transiting the star. Stellar flybys can gravitationally perturb objects in the outer comet reservoir, altering their orbits and potentially injecting them into the inner system, thereby triggering exocomet showers. Aims. We assessed the contribution of stellar flybys to the observed exocomet activity by reconstructing the stellar encounter history of β Pictoris in the past and future. Methods. We used Gaia DR3 data, supplemented with radial velocities from complementary spectroscopic surveys, to compile a catalogue of stars currently within 80 pc of β Pictoris. Their orbits were integrated backwards and forwards in time in an axisymmetric Galactic potential (via the GALA package) to identify encounters within 2 pc of the system. Results. We identified 99 416 stars currently within 80 pc of β Pictoris with resolved kinematics. Among these, 49 stars (including the eight components of five binaries) encounter β Pictoris within 2 pc between –1.5 Myr and +2 Myr. For four of the binaries, the centre-of-mass trajectories also pass within 2 pc. We estimated the sample to be more than 60% complete within 0.5 Myr of today. Conclusions. Despite β Pictoris being the eponym of its famous moving group, none of the identified encounters involved its moving group members; all are unrelated field stars. We found no encounter capable of shaping the observed disc structures, although stellar flybys may contribute to the long-term evolution of an Oort Cloud-like structure. Our catalogue constitutes the most complete reconstruction of the β Pictoris encounter history to date and provides a robust foundation for future dynamical simulations.}, author = {Gragera-Más, J. L. and Torres Rodriguez, Santiago and Mustill, A. J. and Villaver, E.}, issn = {1432-0746}, journal = {Astronomy & Astrophysics}, publisher = {EDP Sciences}, title = {{A kinematic history of stellar encounters with Beta Pictoris}}, doi = {10.1051/0004-6361/202555940}, volume = {704}, year = {2025}, } @article{20931, abstract = {Context. Asymmetries in the observed rotational splittings of a multiplet contain information about the star’s rotation profile and internal magnetic field. Moreover, the frequency regularities of multiplets can be used for mode identification. However, to exploit this information, highly accurate theoretical predictions are needed. Aims. We aim to quantify the difference in the predicted mode asymmetries between a 1D perturbative method and a 2D method that includes a 2D stellar structure model, which takes rotation into account. We then place these differences between 1D and 2D methods in the context of asteroseismic measurements of internal magnetic fields. We only focus on the asymmetries and not on possible additional frequency peaks that can arise when the magnetic and rotation axis are misaligned. Methods. We coupled the 1D pulsation codes GYRE and StORM to the 2D stellar structure code ESTER and compared the oscillation predictions with the results from the 2D TOP pulsation code. We focused on zero-age main-sequence models representative of rotating β Cephei pulsators spinning at up to 20 per cent of the critical Keplerian rotation rate. Specifically, we investigated low-radial-order gravity and pressure modes. Results. We find a generally good agreement between the oscillation frequencies resulting from the 1D and 2D pulsation codes. We report differences in predicted mode multiplet asymmetries of mostly below 0.06 d−1. Since the magnetic asymmetries are small compared to the differences in the rotational asymmetries resulting from the 1D and 2D predictions, accurate measurements of the magnetic field are in most cases challenging. Conclusions. Differences in the predicted mode asymmetries of a rotating star between 1D perturbative methods and 2D non-perturbative methods can greatly hinder accurate measurements of internal magnetic fields in main-sequence pulsators with low-order modes. Nevertheless, reasonably accurate measurements could be possible with npg ≥ 2 modes if the internal rotation is roughly below 10 per cent of the Keplerian critical rotation frequency for (aligned) magnetic fields of the order of a few hundred kilogauss. While the differences between the 1D and 2D frequency predictions are mostly too large for internal magnetic field detections, the rotational asymmetries predicted by StORM are in general accurate enough for asteroseismic modelling of the stellar rotation in main-sequence stars with identified low-order modes.}, author = {Mombarg, J. S.G. and Vanlaer, V. and Das, Srijan B and Rieutord, M. and Aerts, C. and Bugnet, Lisa Annabelle and Mathis, S. and Reese, D. R. and Ballot, J.}, issn = {1432-0746}, journal = {Astronomy & Astrophysics}, publisher = {EDP Sciences}, title = {{Is a 1D perturbative method sufficient for asteroseismic modelling of β Cephei pulsators? Implications for measurements of rotation and internal magnetic fields}}, doi = {10.1051/0004-6361/202557247}, volume = {704}, year = {2025}, } @article{20932, abstract = {Identifying Lyman continuum (LyC) leakers at intermediate redshifts is crucial for understanding the properties of cosmic reionizers because the opacity of the intergalactic medium (IGM) prevents the direct detection of LyC emission from sources during the Epoch of Reionization (EoR). In this study, we confirm two new LyC candidate leakers at z ∼ 3 in the Abell 2744 cluster field, with absolute escape fractions (fesc) of 0.83−0.80+0.15 and 0.74−0.70+0.23, respectively. The LyC emission was detected using HST/WFC3/F275W and F336W imaging. These two candidate leakers appear to be faint (MUV = −17.61 ± 0.06 and −18.22 ± 0.10), exhibit blue UV continuum slopes (β = −2.43 ± 0.05 and −1.92 ± 0.09), have low masses (M★ ∼ 107.51 ± 0.03 and 107.17 ± 0.15 M⊙) and Lyα equivalent widths of 90 ± 3 Å and 28 ± 12 Å, respectively. These two LyC candidate leakers were detected in a catalog of 91 spectroscopically confirmed sources using public spectra from the JWST and/or MUSE. We also analyzed properties that were proposed as indirect indicators of LyC emission, such as Lyα, the O32 ratio, and M★. We created a galaxy subsample that was selected according to these properties, stacked the LyC observations of this subsample, and assessed the limits of the escape fractions in the stacks. We aim to enhance our understanding of LyC escape mechanisms and improve our predictions of the LyC fesc during the EoR by analyzing the individual candidates and the stacks in the context of the currently limited sample of known LyC leakers at z ∼ 3.}, author = {Liu, Y. and Mascia, Sara and Pentericci, L. and Watson, P. and Alavi, A. and Bergamini, P. and Bradač, M. and Calabrò, A. and Glazebrook, K. and Henry, A. and Llerena, M. and Merlin, E. and Metha, B. and Nanayakkara, T. and Napolitano, L. and Roy, N. and Siana, B. and Vanzella, E. and Vulcani, B. and Wang, X.}, issn = {1432-0746}, journal = {Astronomy & Astrophysics}, publisher = {EDP Sciences}, title = {{A Lyman continuum analysis of ∼100 galaxies at z spec∼ 3 in the Abell 2744 cluster field}}, doi = {10.1051/0004-6361/202556410}, volume = {704}, year = {2025}, } @article{20933, abstract = {Photo-responsive systems based on azobenzenes usually require UV light for E→Z isomerization, limiting their applicability, especially in biomedical contexts. Disequilibration by sensitization of azobenzene under confinement (DESC) has recently emerged as a supramolecular strategy to bypass this limitation without the need to derivatize the azobenzene scaffold. Here, we expand DESC to water-soluble azopolymers obtained by RAFT polymerization and systematically investigate the interplay between the polymer structure and DESC efficiency. Using this approach, we achieved as much as 85% of the direct photoexcitation (UV) switching efficiency, while utilizing low-energy (yellow) light. These results establish general design principles for combining DESC with polymeric systems, opening new opportunities for the development of functional materials driven with low-energy light.}, author = {Meteling, Henning Jörn and Gemen, Julius and Häkkinen, Satu and Klajn, Rafal and Priimagi, Arri}, issn = {1521-3773}, journal = {Angewandte Chemie International Edition}, publisher = {Wiley}, title = {{Sensitized disequilibration of water-soluble azopolymers}}, doi = {10.1002/anie.202523447}, year = {2025}, } @article{20934, abstract = { Supervised learning for causal discovery from observational data often achieves competitive performance despite seemingly avoiding the explicit assumptions that traditional methods require for identifiability. In this work, we analyze CSIvA (Ke et al., 2023) on bivariate causal models, a transformer architecture for amortized inference promising to train on synthetic data and transfer to real ones. First, we bridge the gap with identifiability theory, showing that the training distribution implicitly defines a prior on the causal model of the test observations: consistent with classical approaches, good performance is achieved when we have a good prior on the test data, and the underlying model is identifiable. Second, we find that CSIvA can not generalize to classes of causal models unseen during training: to overcome this limitation, we theoretically and empirically analyze \textit{when} training CSIvA on datasets generated by multiple identifiable causal models with different structural assumptions improves its generalization at test time. Overall, we find that amortized causal discovery still adheres to identifiability theory, violating the previous hypothesis from Lopez-Paz et al. (2015) that supervised learning methods could overcome its restrictions.}, author = {Montagna, Francesco and Cairney-Leeming, Maximilian T and Sridhar, Dhanya and Locatello, Francesco}, issn = {2835-8856}, journal = {Transactions on Machine Learning Research}, publisher = {ML Research Press}, title = {{Demystifying amortized causal discovery with transformers}}, year = {2025}, } @article{20935, abstract = {In situ cryo-electron tomography (cryo-ET) has emerged as the method of choice to investigate the structures of biomolecules in their native context. However, challenges remain for the efficient production and sharing of large-scale cryo-ET datasets. Here, we combined cryogenic plasma-based focused ion beam (cryo-PFIB) milling with recent advances in cryo-ET acquisition and processing to generate a dataset of 1,829 annotated tomograms of the green alga Chlamydomonas reinhardtii, which we provide as a community resource to drive method development and inspire biological discovery. To assay data quality, we performed subtomogram averaging of both soluble and membrane-bound complexes ranging in size from >3 MDa to ∼200 kDa, including 80S ribosomes, Rubisco, nucleosomes, microtubules, clathrin, photosystem II, and mitochondrial ATP synthase. The majority of these density maps reached sub-nanometer resolution, demonstrating the potential of this C. reinhardtii dataset as well as the promise of modern cryo-ET workflows and open data sharing to empower visual proteomics.}, author = {Kelley, Ron and Khavnekar, Sagar and Righetto, Ricardo D. and Heebner, Jessica and Obr, Martin and Zhang, Xianjun and Chakraborty, Saikat and Tagiltsev, Grigory and Michael, Alicia and Van Dorst, Sofie and Waltz, Florent and Mccafferty, Caitlyn L. and Lamm, Lorenz and Zufferey, Simon and Van Der Stappen, Philippe and Van Den Hoek, Hugo and Wietrzynski, Wojciech and Harar, Pavol and Wan, William and Briggs, John A.G. and Plitzko, Jürgen M. and Engel, Benjamin D. and Kotecha, Abhay}, issn = {1097-4164}, journal = {Molecular Cell}, publisher = {Elsevier}, title = {{Toward community-driven visual proteomics with large-scale cryo-electron tomography of Chlamydomonas reinhardtii}}, doi = {10.1016/j.molcel.2025.11.029}, year = {2025}, } @misc{20936, abstract = {Supplementary material for Mombarg et al. (2025, A&A). Title: "Is a 1D perturbative method sufficient for asteroseismic modelling of ~Cephei pulsators? Implications for measurements of rotation and internal magnetic fields" Content: - Non-rotating ESTER models and associated .GSM models. (Xini = 0.71, Zini = 0.014, vertical/horizonal viscosity 10^7 cm^2/s, vertical chemical diffusion 10^4 cm^2/s for evolution model. More details on the ESTER models can be found in the ESTER manual. - Rotational asymmetries computed with StORM and TOP in 1/d, and the central m=0 frequency from TOP in 1/d. (all_A*_new.pkl) - Magnetic asymmetries in 1/d for different obliquity angles between 0 and 90 deg for ZAMS and MAMS model, for B_0 = 75 kG. *_nu key gives unperturbed mode frequencies, *_npg the radial order (asym_dict.pkl, asym_dict_evol.pkl)}, author = {Mombarg, Joey and Vanlaer, Vincent and Das, Srijan B and Rieutord, Michel and Aerts, Conny and Bugnet, Lisa Annabelle and Mathis, Stephane and Reese, Daniel and Ballot, Jerome}, publisher = {Zenodo}, title = {{Is a 1D perturbative method sufficient for asteroseismic modelling of β Cephei pulsators?}}, doi = {10.5281/ZENODO.17580178}, year = {2025}, }