[{"publication_identifier":{"issn":["1943-2631"]},"day":"12","has_accepted_license":"1","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1093/genetics/iyag042"}],"status":"public","publication_status":"epub_ahead","external_id":{"pmid":["41677404"]},"article_processing_charge":"Yes (via OA deal)","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"MaRo"}],"OA_type":"hybrid","date_published":"2026-02-12T00:00:00Z","article_type":"original","title":"A quantitative genetic model for indirect genetic effects and genomic imprinting under random and assortative mating","date_created":"2026-03-23T15:02:54Z","article_number":"iyag042","author":[{"last_name":"Krätschmer","id":"30d4014e-7753-11eb-b44b-db6d61112e73","orcid":"0000-0002-5636-9259","first_name":"Ilse","full_name":"Krätschmer, Ilse"},{"first_name":"Matthew Richard","full_name":"Robinson, Matthew Richard","last_name":"Robinson","id":"E5D42276-F5DA-11E9-8E24-6303E6697425","orcid":"0000-0001-8982-8813"}],"doi":"10.1093/genetics/iyag042","acknowledgement":"We thank members of the Medical Genomics group at ISTA for their comments, which improved this manuscript. This work was funded by an SNSF Eccellenza Grant to MRR (PCEGP3-181181), and by core funding from the Institute of Science and Technology Austria.","ddc":["570"],"pmid":1,"year":"2026","publication":"Genetics","publisher":"Oxford University Press","quality_controlled":"1","oa_version":"Published Version","corr_author":"1","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"date_updated":"2026-06-18T08:31:14Z","language":[{"iso":"eng"}],"_id":"21484","abstract":[{"lang":"eng","text":"An individual's phenotype reflects a complex interplay of the direct effects of their DNA, epigenetic modifications of their DNA induced by their parents, and indirect effects of their parents' DNA. Here, we derive how the genetic variance within a population is changed under the influence of indirect maternal, paternal and parent-of-origin effects under random mating. We also consider indirect effects of a sibling, in particular how the genetic variance is altered when looking at the phenotypic difference between two siblings. The calculations are then extended to include assortative mating (AM), which alters the variance by inducing increased homozygosity and correlations within and across loci. AM likely leads to covariance of parental genetic effects, a measure of the similarity of parents in the indirect effects they have on their children. We propose that this assortment for parental characteristics, where biological parents create similar environments for their children, can create shared parental effects across traits and the appearance of cross-trait AM. Our theory shows how the resemblance among relatives increases under both AM, indirect and parent-of-origin effects. When our model is used to predict correlations among relatives in human height, we find that explaining the patterns observed in real data requires both indirect genetic effects and assortative mating. The degree to which direct, indirect and epigenetic effects shape the phenotypic variance of complex traits remains an open question that requires large-scale family data to be resolved."}],"oa":1,"related_material":{"link":[{"url":"https://github.com/medical-genomics-group/familyMC","relation":"software"}]},"month":"02","citation":{"ama":"Krätschmer I, Robinson MR. A quantitative genetic model for indirect genetic effects and genomic imprinting under random and assortative mating. <i>Genetics</i>. 2026. doi:<a href=\"https://doi.org/10.1093/genetics/iyag042\">10.1093/genetics/iyag042</a>","ista":"Krätschmer I, Robinson MR. 2026. A quantitative genetic model for indirect genetic effects and genomic imprinting under random and assortative mating. Genetics., iyag042.","chicago":"Krätschmer, Ilse, and Matthew Richard Robinson. “A Quantitative Genetic Model for Indirect Genetic Effects and Genomic Imprinting under Random and Assortative Mating.” <i>Genetics</i>. Oxford University Press, 2026. <a href=\"https://doi.org/10.1093/genetics/iyag042\">https://doi.org/10.1093/genetics/iyag042</a>.","apa":"Krätschmer, I., &#38; Robinson, M. R. (2026). A quantitative genetic model for indirect genetic effects and genomic imprinting under random and assortative mating. <i>Genetics</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/genetics/iyag042\">https://doi.org/10.1093/genetics/iyag042</a>","short":"I. Krätschmer, M.R. Robinson, Genetics (2026).","mla":"Krätschmer, Ilse, and Matthew Richard Robinson. “A Quantitative Genetic Model for Indirect Genetic Effects and Genomic Imprinting under Random and Assortative Mating.” <i>Genetics</i>, iyag042, Oxford University Press, 2026, doi:<a href=\"https://doi.org/10.1093/genetics/iyag042\">10.1093/genetics/iyag042</a>.","ieee":"I. Krätschmer and M. R. Robinson, “A quantitative genetic model for indirect genetic effects and genomic imprinting under random and assortative mating,” <i>Genetics</i>. Oxford University Press, 2026."},"type":"journal_article","OA_place":"publisher","PlanS_conform":"1","license":"https://creativecommons.org/licenses/by/4.0/"},{"DOAJ_listed":"1","OA_place":"publisher","citation":{"short":"S. Akther, A.B. Lee, A. Konno, A. Asiminas, M. Vittani, T. Mishima, H. Hirai, C.F. Meehan, J. Duran, J. Guinovart, H. Ashida, T. Morita, O. Baba, R. Shigemoto, M. Nedergaard, H. Hirase, IScience 29 (2026).","apa":"Akther, S., Lee, A. B., Konno, A., Asiminas, A., Vittani, M., Mishima, T., … Hirase, H. (2026). Distribution and functional significance of rodent cerebellar glycogen. <i>IScience</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.isci.2026.115192\">https://doi.org/10.1016/j.isci.2026.115192</a>","ama":"Akther S, Lee AB, Konno A, et al. Distribution and functional significance of rodent cerebellar glycogen. <i>iScience</i>. 2026;29(4). doi:<a href=\"https://doi.org/10.1016/j.isci.2026.115192\">10.1016/j.isci.2026.115192</a>","chicago":"Akther, Sonam, Ashley Bomin Lee, Ayumu Konno, Antonis Asiminas, Marta Vittani, Tsuneko Mishima, Hirokazu Hirai, et al. “Distribution and Functional Significance of Rodent Cerebellar Glycogen.” <i>IScience</i>. Elsevier, 2026. <a href=\"https://doi.org/10.1016/j.isci.2026.115192\">https://doi.org/10.1016/j.isci.2026.115192</a>.","ista":"Akther S, Lee AB, Konno A, Asiminas A, Vittani M, Mishima T, Hirai H, Meehan CF, Duran J, Guinovart J, Ashida H, Morita T, Baba O, Shigemoto R, Nedergaard M, Hirase H. 2026. Distribution and functional significance of rodent cerebellar glycogen. iScience. 29(4), 115192.","ieee":"S. Akther <i>et al.</i>, “Distribution and functional significance of rodent cerebellar glycogen,” <i>iScience</i>, vol. 29, no. 4. Elsevier, 2026.","mla":"Akther, Sonam, et al. “Distribution and Functional Significance of Rodent Cerebellar Glycogen.” <i>IScience</i>, vol. 29, no. 4, 115192, Elsevier, 2026, doi:<a href=\"https://doi.org/10.1016/j.isci.2026.115192\">10.1016/j.isci.2026.115192</a>."},"type":"journal_article","month":"03","oa":1,"abstract":[{"text":"The mammalian brain stores glucose, the main circulating energy substrate, as glycogen. In rodents, the cerebellum contains relatively high glycogen levels, yet its cellular and subcellular distribution remains poorly defined. Using monoclonal antibodies against glycogen, we examined its distribution in the mouse cerebellar cortex. Glycogen was predominantly localized to Bergmann glia (BG) processes in the molecular layer and was also detected in Purkinje cells (PCs), the principal cerebellar neurons. To assess the functional significance of cerebellar glycogen, we analyzed behavior in mice lacking glycogen synthase 1 (Gys1) in BG or PCs using a floxed Gys1 line. Gys1 deficiency in either PCs or GFAP-positive cells reduced anxiety-like behavior, whereas combined deletion caused PC degeneration and ataxia. These findings reveal a critical role for glycogen metabolism in both astrocytes and neurons in cerebellar function.","lang":"eng"}],"_id":"21502","date_updated":"2026-06-18T08:32:22Z","language":[{"iso":"eng"}],"oa_version":"Published Version","quality_controlled":"1","publisher":"Elsevier","volume":29,"year":"2026","publication":"iScience","pmid":1,"scopus_import":"1","intvolume":"        29","ddc":["570"],"acknowledgement":"This work was supported by the Novo Nordisk Foundation (NNFOC0058058, H. Hirase), the Danmarks Frie Forskningsfond (0134-00107B and 5283-00069A, H.Hirase), the Lundbeck Foundation, Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research (KAKENHI) program (22K06454/24H01221, A.K.; 23K27482, H.Hirai), the Japan Agency for Medical Research and Development (AMED) Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS) (JP21dm0207111, H. Hirai), AMED Brain/MINDS 2.0 (JP23wm0625001 and JP24wm0625103, H. Hirai), and grants from the Spanish Ministerio de Ciencia e Innovación (MCIU/FEDER/AEI) (PID2020-118699 GB-100, J.D.) and the Fundación Ramón Areces (J.D.). Sonam Akther has been supported by the RIKEN IPA fellowship. We are thankful to Dr. Yuki Oe for his support in the initial stage of this study and to Dan Xue for his help with the graphical abstract. We thank Dr. Pia Weikop for providing CTN research infrastructure. The authors declare no competing financial interests.","doi":"10.1016/j.isci.2026.115192","issue":"4","title":"Distribution and functional significance of rodent cerebellar glycogen","date_created":"2026-03-29T22:07:07Z","author":[{"last_name":"Akther","full_name":"Akther, Sonam","first_name":"Sonam"},{"first_name":"Ashley Bomin","full_name":"Lee, Ashley Bomin","last_name":"Lee"},{"last_name":"Konno","first_name":"Ayumu","full_name":"Konno, Ayumu"},{"full_name":"Asiminas, Antonis","first_name":"Antonis","last_name":"Asiminas"},{"last_name":"Vittani","first_name":"Marta","full_name":"Vittani, Marta"},{"last_name":"Mishima","first_name":"Tsuneko","full_name":"Mishima, Tsuneko"},{"last_name":"Hirai","first_name":"Hirokazu","full_name":"Hirai, Hirokazu"},{"full_name":"Meehan, Claire Francesca","first_name":"Claire Francesca","last_name":"Meehan"},{"last_name":"Duran","first_name":"Jordi","full_name":"Duran, Jordi"},{"first_name":"Joan","full_name":"Guinovart, Joan","last_name":"Guinovart"},{"last_name":"Ashida","full_name":"Ashida, Hitoshi","first_name":"Hitoshi"},{"last_name":"Morita","first_name":"Tsuyoshi","full_name":"Morita, Tsuyoshi"},{"last_name":"Baba","first_name":"Otto","full_name":"Baba, Otto"},{"full_name":"Shigemoto, Ryuichi","first_name":"Ryuichi","orcid":"0000-0001-8761-9444","last_name":"Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Maiken","full_name":"Nedergaard, Maiken","last_name":"Nedergaard"},{"first_name":"Hajime","full_name":"Hirase, Hajime","last_name":"Hirase"}],"article_number":"115192","article_type":"original","date_published":"2026-03-17T00:00:00Z","OA_type":"gold","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"RySh"}],"article_processing_charge":"Yes","external_id":{"pmid":["41890976"]},"publication_status":"epub_ahead","status":"public","main_file_link":[{"url":"https://doi.org/10.1016/j.isci.2026.115192","open_access":"1"}],"publication_identifier":{"eissn":["2589-0042"]},"day":"17"},{"quality_controlled":"1","publisher":"Springer Nature","corr_author":"1","oa_version":"Published Version","date_updated":"2026-06-18T08:32:52Z","language":[{"iso":"eng"}],"_id":"21436","abstract":[{"text":"The cobalt-intercalated transition metal dichalcogenide CoxTaS2 hosts a rich landscape of magnetic phases that depend sensitively on x. While the stoichiometric compound with x = 1/3 exhibits a single magnetic transition, samples with x≤0.325 display two transitions with an anomalous Hall effect (AHE) emerging in the lower temperature phase. Here, we resolve the spin structure in each phase by employing a suite of magneto-optical probes that include the discovery of anomalous magneto-birefringence: a spontaneous time-reversal sensitive rotation of the principal optic axes. A symmetry-based analysis identifies the AHE-active phase as an anisotropic (2+1)Q state, in which magnetic modulation at one wavevector (Q) differs in symmetry from that at the remaining two. The (2+1)Q state naturally exhibits scalar spin chirality as a mechanism for the AHE and expands the classification of multi-Q magnetic phases.","lang":"eng"}],"oa":1,"type":"journal_article","month":"04","citation":{"ama":"Kruppe J, Rodriguez J, Xu C, Analytis J, Orenstein J, Sunko V. Anisotropic multi-Q order in CoxTaS2. <i>npj Quantum Materials</i>. 2026. doi:<a href=\"https://doi.org/10.1038/s41535-026-00856-w\">10.1038/s41535-026-00856-w</a>","chicago":"Kruppe, Jonathon, Josue Rodriguez, Catherine Xu, James Analytis, Joseph Orenstein, and Veronika Sunko. “Anisotropic Multi-Q Order in CoxTaS2.” <i>Npj Quantum Materials</i>. Springer Nature, 2026. <a href=\"https://doi.org/10.1038/s41535-026-00856-w\">https://doi.org/10.1038/s41535-026-00856-w</a>.","ista":"Kruppe J, Rodriguez J, Xu C, Analytis J, Orenstein J, Sunko V. 2026. Anisotropic multi-Q order in CoxTaS2. npj Quantum Materials., 2507.12588.","short":"J. Kruppe, J. Rodriguez, C. Xu, J. Analytis, J. Orenstein, V. Sunko, Npj Quantum Materials (2026).","apa":"Kruppe, J., Rodriguez, J., Xu, C., Analytis, J., Orenstein, J., &#38; Sunko, V. (2026). Anisotropic multi-Q order in CoxTaS2. <i>Npj Quantum Materials</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41535-026-00856-w\">https://doi.org/10.1038/s41535-026-00856-w</a>","ieee":"J. Kruppe, J. Rodriguez, C. Xu, J. Analytis, J. Orenstein, and V. Sunko, “Anisotropic multi-Q order in CoxTaS2,” <i>npj Quantum Materials</i>. Springer Nature, 2026.","mla":"Kruppe, Jonathon, et al. “Anisotropic Multi-Q Order in CoxTaS2.” <i>Npj Quantum Materials</i>, 2507.12588, Springer Nature, 2026, doi:<a href=\"https://doi.org/10.1038/s41535-026-00856-w\">10.1038/s41535-026-00856-w</a>."},"OA_place":"publisher","arxiv":1,"publication_identifier":{"eissn":["2397-4648"]},"day":"09","status":"public","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1038/s41535-026-00856-w"}],"external_id":{"arxiv":["2507.12588"]},"publication_status":"epub_ahead","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_processing_charge":"Yes","department":[{"_id":"VeSu"}],"OA_type":"gold","date_published":"2026-04-09T00:00:00Z","article_type":"original","date_created":"2026-03-11T10:39:55Z","author":[{"last_name":"Kruppe","first_name":"Jonathon","full_name":"Kruppe, Jonathon"},{"last_name":"Rodriguez","first_name":"Josue","full_name":"Rodriguez, Josue"},{"first_name":"Catherine","full_name":"Xu, Catherine","last_name":"Xu"},{"first_name":"James","full_name":"Analytis, James","last_name":"Analytis"},{"first_name":"Joseph","full_name":"Orenstein, Joseph","last_name":"Orenstein"},{"orcid":"0000-0003-2724-3523","id":"23cb1cf6-2c7a-11ef-91a4-f72fc19f20b3","last_name":"Sunko","full_name":"Sunko, Veronika","first_name":"Veronika"}],"title":"Anisotropic multi-Q order in CoxTaS2","article_number":"2507.12588","ddc":["530"],"doi":"10.1038/s41535-026-00856-w","acknowledgement":"We thank Linda Ye and Yue Sun for helpful discussion. Experimental and theoretical work at LBNL and UC Berkeley was funded by the Quantum Materials (KC2202) program under the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, Materials Sciences and Engineering Division under Contract No. DE-AC02-05CH11231. V.S. and J.O. received support from the Gordon and Betty Moore Foundation’s EPiQS Initiative through Grant GBMF4537 to J.O. at UC Berkeley. J.K. received support from the National Science Foundation Graduate Research Fellowship Program under Grant No. 2146752. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation. During the preparation of this manuscript, we became aware of the following related work: refs. 56,57,58.","year":"2026","publication":"npj Quantum Materials","scopus_import":"1"},{"file_date_updated":"2026-06-19T06:31:16Z","OA_type":"gold","publication_status":"published","external_id":{"pmid":["42221941"]},"department":[{"_id":"LaVe"}],"article_processing_charge":"Yes","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","day":"04","publication_identifier":{"eissn":["2694-2445"]},"status":"public","has_accepted_license":"1","pmid":1,"scopus_import":"1","year":"2026","publication":"ACS Physical Chemistry Au","volume":6,"acknowledgement":"We thank Michael Inkpen, Timothy Su, Masha Kamenetska, and Wanzhuo Shi for comments and Jyotisman Hazarika for data collection. This work was supported in part by the National Science Foundation (NSF-DMR 2241180) and by the Institute of Science and Technology Austria.","doi":"10.1021/acsphyschemau.6c00026","ddc":["540"],"intvolume":"         6","date_created":"2026-06-10T07:38:41Z","author":[{"first_name":"Emma","full_name":"York, Emma","last_name":"York","id":"08dde91e-8e0a-11f0-9d7d-9e8d80864f16"},{"orcid":"0000-0002-6957-6089","last_name":"Venkataraman","id":"9ebb78a5-cc0d-11ee-8322-fae086a32caf","full_name":"Venkataraman, Latha","first_name":"Latha"}],"title":"Scanning tunneling microscope-based break-junction technique - A tutorial","issue":"3","file":[{"date_created":"2026-06-19T06:31:16Z","creator":"dernst","file_size":11251172,"content_type":"application/pdf","checksum":"1dc16bdfb1c1cd3acde802f4350cb42a","access_level":"open_access","success":1,"file_id":"22020","date_updated":"2026-06-19T06:31:16Z","relation":"main_file","file_name":"2026_ACSPhysChem_York.pdf"}],"date_published":"2026-05-04T00:00:00Z","article_type":"original","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"date_updated":"2026-06-19T06:35:58Z","language":[{"iso":"eng"}],"publisher":"American Chemical Society","quality_controlled":"1","oa_version":"Published Version","corr_author":"1","PlanS_conform":"1","OA_place":"publisher","DOAJ_listed":"1","page":"408-424","oa":1,"type":"journal_article","citation":{"ista":"York E, Venkataraman L. 2026. Scanning tunneling microscope-based break-junction technique - A tutorial. ACS Physical Chemistry Au. 6(3), 408–424.","chicago":"York, Emma, and Latha Venkataraman. “Scanning Tunneling Microscope-Based Break-Junction Technique - A Tutorial.” <i>ACS Physical Chemistry Au</i>. American Chemical Society, 2026. <a href=\"https://doi.org/10.1021/acsphyschemau.6c00026\">https://doi.org/10.1021/acsphyschemau.6c00026</a>.","ama":"York E, Venkataraman L. Scanning tunneling microscope-based break-junction technique - A tutorial. <i>ACS Physical Chemistry Au</i>. 2026;6(3):408-424. doi:<a href=\"https://doi.org/10.1021/acsphyschemau.6c00026\">10.1021/acsphyschemau.6c00026</a>","short":"E. York, L. Venkataraman, ACS Physical Chemistry Au 6 (2026) 408–424.","apa":"York, E., &#38; Venkataraman, L. (2026). Scanning tunneling microscope-based break-junction technique - A tutorial. <i>ACS Physical Chemistry Au</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/acsphyschemau.6c00026\">https://doi.org/10.1021/acsphyschemau.6c00026</a>","ieee":"E. York and L. Venkataraman, “Scanning tunneling microscope-based break-junction technique - A tutorial,” <i>ACS Physical Chemistry Au</i>, vol. 6, no. 3. American Chemical Society, pp. 408–424, 2026.","mla":"York, Emma, and Latha Venkataraman. “Scanning Tunneling Microscope-Based Break-Junction Technique - A Tutorial.” <i>ACS Physical Chemistry Au</i>, vol. 6, no. 3, American Chemical Society, 2026, pp. 408–24, doi:<a href=\"https://doi.org/10.1021/acsphyschemau.6c00026\">10.1021/acsphyschemau.6c00026</a>."},"month":"05","_id":"21986","abstract":[{"lang":"eng","text":"Over the past two decades, molecular electronics has made significant progress toward discovering nanoscale analogues of conventional electronic components, largely enabled by the development of the scanning tunneling microscope-based break-junction (STM-BJ) technique. The STM-BJ technique enables precise and highly reproducible measurement of a molecule’s electronic transport properties, making it a powerful technique to explore physiochemical and electrochemical phenomena that are otherwise difficult to access. It has gained substantial popularity in the past 20 years, with experiments becoming increasingly diverse and sophisticated. Despite the wealth of literature, an accessible, practical guide to performing STM-BJ experiments and interpreting the data is largely absent. This tutorial includes a brief background into the development of STM-BJ measurements, followed by detailed explanations of instrumentation, data collection, statistical analysis, variations on standard experiments, and some troubleshooting methods. It is aimed at researchers looking to begin or improve STM-BJ studies in their laboratories, graduate students and postdoctoral researchers learning the technique, and readers seeking to critically evaluate the growing body of STM-BJ literature."}]},{"OA_place":"publisher","DOAJ_listed":"1","oa":1,"citation":{"apa":"Krätschmer, I., Hegemann, L., Hofmeister, R. J., Corfield, E. C., Mahmoudi, M., Delaneau, O., … Robinson, M. R. (n.d.). Separating direct, indirect, and parent-of-origin genetic effects in the human population. <i>Cell Genomics</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.xgen.2026.101277\">https://doi.org/10.1016/j.xgen.2026.101277</a>","short":"I. Krätschmer, L. Hegemann, R.J. Hofmeister, E.C. Corfield, M. Mahmoudi, O. Delaneau, O.A. Andreassen, A. Campbell, C. Hayward, R.E. Marioni, E. Ystrom, A. Havdahl, M.R. Robinson, Cell Genomics (n.d.).","chicago":"Krätschmer, Ilse, Laura Hegemann, Robin J. Hofmeister, Elizabeth C. Corfield, Mahdi Mahmoudi, Olivier Delaneau, Ole A. Andreassen, et al. “Separating Direct, Indirect, and Parent-of-Origin Genetic Effects in the Human Population.” <i>Cell Genomics</i>. Elsevier, n.d. <a href=\"https://doi.org/10.1016/j.xgen.2026.101277\">https://doi.org/10.1016/j.xgen.2026.101277</a>.","ista":"Krätschmer I, Hegemann L, Hofmeister RJ, Corfield EC, Mahmoudi M, Delaneau O, Andreassen OA, Campbell A, Hayward C, Marioni RE, Ystrom E, Havdahl A, Robinson MR. Separating direct, indirect, and parent-of-origin genetic effects in the human population. Cell Genomics., 101277.","ama":"Krätschmer I, Hegemann L, Hofmeister RJ, et al. Separating direct, indirect, and parent-of-origin genetic effects in the human population. <i>Cell Genomics</i>. doi:<a href=\"https://doi.org/10.1016/j.xgen.2026.101277\">10.1016/j.xgen.2026.101277</a>","mla":"Krätschmer, Ilse, et al. “Separating Direct, Indirect, and Parent-of-Origin Genetic Effects in the Human Population.” <i>Cell Genomics</i>, 101277, Elsevier, doi:<a href=\"https://doi.org/10.1016/j.xgen.2026.101277\">10.1016/j.xgen.2026.101277</a>.","ieee":"I. Krätschmer <i>et al.</i>, “Separating direct, indirect, and parent-of-origin genetic effects in the human population,” <i>Cell Genomics</i>. Elsevier."},"month":"06","type":"journal_article","_id":"21987","abstract":[{"lang":"eng","text":"We introduce JODIE, a genetic joint modeling approach that estimates how DNA loci influence human traits by partitioning genetic effects into four components: direct effects (from a child’s alleles), indirect maternal and paternal effects (from parents’ alleles), and parent-of-origin (PofO) effects (dependent on parental transmission of alleles), while uniquely accounting for assortative mating. We analyze 30,000 child-mother-father trios from the Estonian Biobank and the Norwegian Mother, Father, and Child Cohort, focusing on height, body mass index, and childhood educational test scores. We find direct effects to be the largest contributor to trait variation, but combined, indirect parental and PofO effects are similarly substantial. We support our results by within-family genome-wide association testing and identify 276 independently associated DNA regions with a complex interplay between direct, indirect, and PofO effects. By joint modeling, we show that direct, indirect, and PofO effects collectively shape human phenotypic variation across loci genome-wide."}],"language":[{"iso":"eng"}],"date_updated":"2026-06-19T07:00:47Z","publisher":"Elsevier","quality_controlled":"1","oa_version":"Published Version","corr_author":"1","acknowledged_ssus":[{"_id":"ScienComp"}],"scopus_import":"1","pmid":1,"publication":"Cell Genomics","year":"2026","acknowledgement":"We thank Zoltan Kutalik, Peter Visscher, and members of the Robinson group at ISTA for their comments, which improved this manuscript. This work was funded by an SNSF Eccellenza Grant to M.R.R. (PCEGP3-181181) and by core funding from the Institute of Science and Technology Austria.\r\nThe Norwegian Mother, Father, and Child Cohort Study is supported by the Norwegian Ministry of Health and Care Services and the Ministry of Education and Research. We are grateful to all the participating families in Norway who take part in this on-going cohort study. We thank the Norwegian Institute of Public Health (NIPH) for generating high-quality genomic data. The research is part of the HARVEST collaboration, supported by the Research Council of Norway (#229624). We also thank the NORMENT Center for providing genotype data, funded by the Research Council of Norway (#223273), South East Norway Health Authorities, and Stiftelsen Kristian Gerhard Jebsen, and in collaboration with deCODE Genetics. We further thank the Center for Diabetes Research, the University of Bergen for providing genotype data funded by the ERC AdG project SELECTionPREDISPOSED, Stiftelsen Kristian Gerhard Jebsen, Trond Mohn Foundation, the Research Council of Norway, the Novo Nordisk Foundation, the University of Bergen, and the Western Norway Health Authorities. The MoBa work was performed on the TSD (Tjeneste for Sensitive Data) facilities, owned by the University of Oslo, operated and developed by the TSD service group at the University of Oslo, IT Department (USIT, tsd-drift@usit.uio.no). E.Y. is supported by the European Union (grant numbers 101045526 and 101073237) and the Research Council of Norway (grant numbers 336078, 288083, and 331640).\r\nWe would like to acknowledge the participants and investigators of the Generation Scotland Cohort study. Generation Scotland received core support from the Chief Scientist Office of the Scottish Government Health Directorates (CZD/16/6) and the Scottish Funding Council (HR03006). Genotyping and methylation typing of the GS:SFHS samples was carried out by the Genetics Core Laboratory at the Wellcome Trust Clinical Research Facility, Edinburgh, Scotland and was funded by the Medical Research Council UK and the Wellcome Trust (Wellcome Trust Strategic Award “STratifying Resilience and Depression Longitudinally” [STRADL] ref. 104036/Z/14/Z).\r\nWe would like to thank and acknowledge the participants and investigators of the Estonian Biobank (EstBB) study. The research was conducted using the Estonian Center of Genomics/Roadmap II funded by the Estonian Research Council (project number TT17).\r\nNorwegian analyses were performed on resources provided by Sigma2 - the National Infrastructure for High-Performance Computing and Data Storage in Norway. Estonian Data analysis was carried out in the High-Performance Computing Center cloud provided by University of Tartu. Analysis of the Generation Scotland data and the summary statistics obtained from the other analyses was conducted at IST Austria and is supported by the Scientific Service Units (SSU) of IST Austria through resources provided by Scientific Computing (SciComp).","doi":"10.1016/j.xgen.2026.101277","article_number":"101277","date_created":"2026-06-10T07:39:08Z","title":"Separating direct, indirect, and parent-of-origin genetic effects in the human population","author":[{"id":"30d4014e-7753-11eb-b44b-db6d61112e73","last_name":"Krätschmer","orcid":"0000-0002-5636-9259","first_name":"Ilse","full_name":"Krätschmer, Ilse"},{"last_name":"Hegemann","first_name":"Laura","full_name":"Hegemann, Laura"},{"last_name":"Hofmeister","first_name":"Robin J.","full_name":"Hofmeister, Robin J."},{"last_name":"Corfield","full_name":"Corfield, Elizabeth C.","first_name":"Elizabeth C."},{"first_name":"Mahdi","full_name":"Mahmoudi, Mahdi","last_name":"Mahmoudi"},{"last_name":"Delaneau","first_name":"Olivier","full_name":"Delaneau, Olivier"},{"full_name":"Andreassen, Ole A.","first_name":"Ole A.","last_name":"Andreassen"},{"last_name":"Campbell","full_name":"Campbell, Archie","first_name":"Archie"},{"last_name":"Hayward","first_name":"Caroline","full_name":"Hayward, Caroline"},{"full_name":"Marioni, Riccardo E.","first_name":"Riccardo E.","last_name":"Marioni"},{"last_name":"Ystrom","first_name":"Eivind","full_name":"Ystrom, Eivind"},{"last_name":"Havdahl","full_name":"Havdahl, Alexandra","first_name":"Alexandra"},{"orcid":"0000-0001-8982-8813","id":"E5D42276-F5DA-11E9-8E24-6303E6697425","last_name":"Robinson","full_name":"Robinson, Matthew Richard","first_name":"Matthew Richard"}],"date_published":"2026-06-09T00:00:00Z","project":[{"name":"Improving estimation and prediction of common complex disease risk","grant_number":"PCEGP3_181181","_id":"9B8D11D6-BA93-11EA-9121-9846C619BF3A"}],"article_type":"original","OA_type":"gold","publication_status":"inpress","external_id":{"pmid":["40909755"]},"department":[{"_id":"MaRo"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_processing_charge":"Yes","day":"09","publication_identifier":{"eissn":["2666-979X"]},"status":"public","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1016/j.xgen.2026.101277"}]},{"publication_status":"submitted","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_processing_charge":"No","department":[{"_id":"GradSch"},{"_id":"JiFr"}],"day":"30","status":"public","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1101/2025.10.07.680881"}],"has_accepted_license":"1","OA_type":"green","title":"MAKR6 integrates TMK and CAMEL/CANAR signalling for auxin canalization in Arabidopsis","date_created":"2026-06-13T16:57:07Z","author":[{"id":"f43371a3-09ff-11eb-8013-bd0c6a2f6de8","last_name":"Ge","orcid":"0000-0001-9381-3577","first_name":"Zengxiang","full_name":"Ge, Zengxiang"},{"first_name":"Lilla","full_name":"Koczka, Lilla","last_name":"Koczka"},{"first_name":"Ewa","full_name":"Mazur, Ewa","last_name":"Mazur"},{"first_name":"Gergely","full_name":"Molnar, Gergely","id":"34F1AF46-F248-11E8-B48F-1D18A9856A87","last_name":"Molnar"},{"last_name":"Vladimirtsev","id":"60466724-5355-11ee-ae5a-fa55e8f99c3d","first_name":"Dmitrii","full_name":"Vladimirtsev, Dmitrii"},{"last_name":"Kassem","full_name":"Kassem, Nada","first_name":"Nada"},{"first_name":"Sara","full_name":"Ait Ikene, Sara","id":"6a0bb896-6bad-11f1-9bef-906e9eb76034","last_name":"Ait Ikene"},{"last_name":"Fiedler","id":"7c417475-8972-11ed-ae7b-8b674ca26986","first_name":"Lukas","full_name":"Fiedler, Lukas"},{"id":"4159519E-F248-11E8-B48F-1D18A9856A87","last_name":"Friml","orcid":"0000-0002-8302-7596","first_name":"Jiří","full_name":"Friml, Jiří"}],"date_published":"2026-05-30T00:00:00Z","project":[{"name":"Cyclic nucleotides as second messengers in plants","grant_number":"101142681","_id":"8f347782-16d5-11f0-9cad-8c19706ee739"},{"name":"Peptide receptors for auxin canalization in Arabidopsis","grant_number":"I06123","_id":"bd76d395-d553-11ed-ba76-f678c14f9033"},{"name":"Guanylate cyclase activity of TIR1/AFBs auxin receptors","_id":"7bcece63-9f16-11ee-852c-ae94e099eeb6","grant_number":"P37051"}],"scopus_import":"1","publication":"bioRxiv","year":"2026","doi":"10.1101/2025.10.07.680881","acknowledgement":"We would like to thank Dr. Yvon Jaillais (ENS, Lyon) for sharing MAKR2 materials. This research was supported by the Scientific Service Units (SSU) of ISTA through resources provided by the Imaging & Optics Facility (IOF) and the Lab Support Facility (LSF). The research in the Friml group leading to these results was funded by the European Research Council (ERC): 101142681 CYNIPS; and the Austrian Science Fund (FWF): I 6123-B and P 37051-B. Ewa Mazur was supported by the National Science Centre (NCN), Poland, under the OPUS call in the WEAVE programme: 2021/43/I/NZ1/01835.","ddc":["580"],"tmp":{"image":"/images/cc_by_nc_nd.png","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode"},"language":[{"iso":"eng"}],"date_updated":"2026-06-19T07:14:01Z","oa_version":"Preprint","corr_author":"1","oa":1,"type":"preprint","month":"05","citation":{"chicago":"Ge, Zengxiang, Lilla Koczka, Ewa Mazur, Gergely Molnar, Dmitrii Vladimirtsev, Nada Kassem, Sara Ait Ikene, Lukas Fiedler, and Jiří Friml. “MAKR6 Integrates TMK and CAMEL/CANAR Signalling for Auxin Canalization in Arabidopsis.” <i>BioRxiv</i>, n.d. <a href=\"https://doi.org/10.1101/2025.10.07.680881\">https://doi.org/10.1101/2025.10.07.680881</a>.","ista":"Ge Z, Koczka L, Mazur E, Molnar G, Vladimirtsev D, Kassem N, Ait Ikene S, Fiedler L, Friml J. MAKR6 integrates TMK and CAMEL/CANAR signalling for auxin canalization in Arabidopsis. bioRxiv, <a href=\"https://doi.org/10.1101/2025.10.07.680881\">10.1101/2025.10.07.680881</a>.","ama":"Ge Z, Koczka L, Mazur E, et al. MAKR6 integrates TMK and CAMEL/CANAR signalling for auxin canalization in Arabidopsis. <i>bioRxiv</i>. doi:<a href=\"https://doi.org/10.1101/2025.10.07.680881\">10.1101/2025.10.07.680881</a>","short":"Z. Ge, L. Koczka, E. Mazur, G. Molnar, D. Vladimirtsev, N. Kassem, S. Ait Ikene, L. Fiedler, J. Friml, BioRxiv (n.d.).","apa":"Ge, Z., Koczka, L., Mazur, E., Molnar, G., Vladimirtsev, D., Kassem, N., … Friml, J. (n.d.). MAKR6 integrates TMK and CAMEL/CANAR signalling for auxin canalization in Arabidopsis. <i>bioRxiv</i>. <a href=\"https://doi.org/10.1101/2025.10.07.680881\">https://doi.org/10.1101/2025.10.07.680881</a>","ieee":"Z. Ge <i>et al.</i>, “MAKR6 integrates TMK and CAMEL/CANAR signalling for auxin canalization in Arabidopsis,” <i>bioRxiv</i>. .","mla":"Ge, Zengxiang, et al. “MAKR6 Integrates TMK and CAMEL/CANAR Signalling for Auxin Canalization in Arabidopsis.” <i>BioRxiv</i>, doi:<a href=\"https://doi.org/10.1101/2025.10.07.680881\">10.1101/2025.10.07.680881</a>."},"_id":"21994","abstract":[{"text":"Adaptive plant development is orchestrated, among others, by directional, intercellular transport of the phytohormone auxin. Self-organizing development, such as flexible vasculature formation, depends on so-called auxin canalization, manifested by the gradual formation of auxin transport channels through feedback between auxin signalling and transport. Herein, we identify MAKR6 as an important, novel component in this feedback. MAKR6 expression accumulates strongly in vascular cells and is tightly regulated by auxin via the Aux/IAA-ARF-WRKY23 transcriptional network. MAKR6 is required for auxin canalization-dependent processes, including leaf venation, vasculature regeneration, and de novo auxin channel formation from local auxin sources. Mechanistically, MAKR6 interacts with the PIN1 auxin transporter, modulating its trafficking and polarization. MAKR6 also associates with and integrates two key receptor-like kinase complexes involved in canalization, TMK1/4 and the CAMEL-CANAR. Together, our study establishes MAKR6 as a multifaceted regulator that couples transcriptional auxin signalling to PIN1 repolarization and coordinates multiple RLK-mediated signalling pathways during canalization. This provides mechanistic insights into auxin canalization and exemplifies a framework for exploring similar regulatory nodes in other developmental contexts.","lang":"eng"}],"license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","OA_place":"repository"},{"_id":"21998","abstract":[{"text":"Little Red Dots (LRDs), among the most enigmatic high-redshift discoveries by JWST, are commonly believed to be powered by accreting supermassive black holes. Here, we explore the possibility that these sources are globular clusters in formation, with rest-frame UV arising from a very young stellar population and rest-frame optical from a short-lived supermassive (>104 M⊙) star. The spectral profiles of LRDs are broadly consistent with this scenario, though the observed temperatures and bolometric luminosities favor emission reprocessed by optically thick continuum-driven winds not fully captured by current models. The LRD z ∼ 5−7 UV luminosity function naturally evolves, under standard evolutionary and mass-loss prescriptions, into a present-day mass function with a turnover at log10(M*/M⊙) = 5.3 and an exponential cutoff at high masses, consistent with local globular cluster populations. We estimate the total present-day number density of LRDs formed across all redshifts to be ≈0.3 Mpc−3, similar within uncertainties to local globular clusters. The observed LRD redshift range matches the age distribution of metal-poor globular clusters, without current LRD counterparts to the metal-rich population. If LRDs are globular clusters in formation, we predict chemical abundance patterns characteristic of multiple stellar populations, including enhanced He and N, and potential Na–O and Al–Mg anticorrelations. These results offer a local perspective to explore this surprisingly abundant population of distant sources, and a potential new window into extreme stellar astrophysics in the early Universe.","lang":"eng"}],"oa":1,"citation":{"apa":"Chisholm, J., Berg, D. A., Boylan-Kolchin, M., De Graaff, A., Furtak, L. J., Kokorev, V., … Sander, A. A. C. (2026). Little Red Dots as globular clusters in formation. <i>The Astrophysical Journal Letters</i>. IOP Publishing. <a href=\"https://doi.org/10.3847/2041-8213/ae6dae\">https://doi.org/10.3847/2041-8213/ae6dae</a>","short":"J. Chisholm, D.A. Berg, M. Boylan-Kolchin, A. De Graaff, L.J. Furtak, V. Kokorev, J.J. Matthee, J.B. Muñoz, R.P. Naidu, A.A.C. Sander, The Astrophysical Journal Letters 1004 (2026).","ama":"Chisholm J, Berg DA, Boylan-Kolchin M, et al. Little Red Dots as globular clusters in formation. <i>The Astrophysical Journal Letters</i>. 2026;1004(1). doi:<a href=\"https://doi.org/10.3847/2041-8213/ae6dae\">10.3847/2041-8213/ae6dae</a>","chicago":"Chisholm, John, Danielle A. Berg, Michael Boylan-Kolchin, Anna De Graaff, Lukas J. Furtak, Vasily Kokorev, Jorryt J Matthee, Julian B. Muñoz, Rohan P. Naidu, and Andreas A.C. Sander. “Little Red Dots as Globular Clusters in Formation.” <i>The Astrophysical Journal Letters</i>. IOP Publishing, 2026. <a href=\"https://doi.org/10.3847/2041-8213/ae6dae\">https://doi.org/10.3847/2041-8213/ae6dae</a>.","ista":"Chisholm J, Berg DA, Boylan-Kolchin M, De Graaff A, Furtak LJ, Kokorev V, Matthee JJ, Muñoz JB, Naidu RP, Sander AAC. 2026. Little Red Dots as globular clusters in formation. The Astrophysical Journal Letters. 1004(1), L4.","mla":"Chisholm, John, et al. “Little Red Dots as Globular Clusters in Formation.” <i>The Astrophysical Journal Letters</i>, vol. 1004, no. 1, L4, IOP Publishing, 2026, doi:<a href=\"https://doi.org/10.3847/2041-8213/ae6dae\">10.3847/2041-8213/ae6dae</a>.","ieee":"J. Chisholm <i>et al.</i>, “Little Red Dots as globular clusters in formation,” <i>The Astrophysical Journal Letters</i>, vol. 1004, no. 1. IOP Publishing, 2026."},"type":"journal_article","month":"06","OA_place":"publisher","DOAJ_listed":"1","arxiv":1,"PlanS_conform":"1","publisher":"IOP Publishing","quality_controlled":"1","oa_version":"Published Version","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"date_updated":"2026-06-19T09:50:33Z","language":[{"iso":"eng"}],"date_published":"2026-06-10T00:00:00Z","article_type":"original","title":"Little Red Dots as globular clusters in formation","article_number":"L4","author":[{"last_name":"Chisholm","first_name":"John","full_name":"Chisholm, John"},{"last_name":"Berg","full_name":"Berg, Danielle A.","first_name":"Danielle A."},{"last_name":"Boylan-Kolchin","first_name":"Michael","full_name":"Boylan-Kolchin, Michael"},{"full_name":"De Graaff, Anna","first_name":"Anna","last_name":"De Graaff"},{"first_name":"Lukas J.","full_name":"Furtak, Lukas J.","last_name":"Furtak"},{"last_name":"Kokorev","full_name":"Kokorev, Vasily","first_name":"Vasily"},{"full_name":"Matthee, Jorryt J","first_name":"Jorryt J","orcid":"0000-0003-2871-127X","id":"7439a258-f3c0-11ec-9501-9df22fe06720","last_name":"Matthee"},{"last_name":"Muñoz","first_name":"Julian B.","full_name":"Muñoz, Julian B."},{"last_name":"Naidu","full_name":"Naidu, Rohan P.","first_name":"Rohan P."},{"last_name":"Sander","first_name":"Andreas A.C.","full_name":"Sander, Andreas A.C."}],"date_created":"2026-06-14T22:01:42Z","issue":"1","file":[{"file_name":"2026_AstrophysicalJourLetters_Chisholm.pdf","date_updated":"2026-06-19T09:45:21Z","relation":"main_file","content_type":"application/pdf","checksum":"66949af6e620c8ef37de42688829a3e3","access_level":"open_access","file_id":"22098","success":1,"file_size":919919,"creator":"dernst","date_created":"2026-06-19T09:45:21Z"}],"acknowledgement":"We thank the referees for detailed and highly constructive reports that significantly improved the scope and breadth of the manuscript. J.C. thanks Hollis Akins, Volker Bromm, Rui Chaves-Marques, Steve Finkelstein, Karl Gebhardt, Keith Hawkins, Harley Katz, Stellar Offner, Daniel Schaerer, Grace Telford, and Jorick Vink for conversations that improved the Letter. A.d.G. acknowledges support from a Clay Fellowship awarded by the Smithsonian Astrophysical Observatory. M.B.K. acknowledges support from NSF grants AST-2108962 and AST-2408247; NASA grant 80NSSC22K0827; HST-GO-16686, HST-AR-17028, JWST-GO-03788, and JWST-AR-06278 from the Space Telescope Science Institute, which is operated by AURA, Inc., under NASA contract NAS5-26555; and from the Samuel T. and Fern Yanagisawa Regents Professorship in Astronomy at UT Austin. A.A.C.S. acknowledges support by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) in the form of an Emmy Noether Research Group—Project-ID 445674056 (SA4064/1-1, PI Sander). A.A.C.S. further acknowledges support from the Deutsches Zentrum für Luft und Raumfahrt (DLR) grant grants 50 OR 2509 (PI: A.A.C. Sander) and 50 OR 2306 (PI: V. Ramachandran/A.A.C. Sander) as well as from the Federal Ministry of Research, Technology, and Space (BMFTR) and the Baden-Württemberg Ministry of Science as part of the Excellence Strategy of the German Federal and State Governments. This project was cofunded by the European Union (Project 101183150—OCEANS).\r\n\r\nThis work is based in part on observations made with the NASA/ESA/CSA James Webb Space Telescope. The data were obtained from the Mikulski Archive for Space Telescopes at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-03127 for JWST. These observations are associated with programs 1180, 1181, 1208, 1212, 1213, 1215, 1286, 1345, 1433, 2198, 2561, 2750, 2767, 4106, 4233, 5105, 5224, 6368, and 6585.","doi":"10.3847/2041-8213/ae6dae","ddc":["520"],"intvolume":"      1004","scopus_import":"1","publication":"The Astrophysical Journal Letters","year":"2026","volume":1004,"publication_identifier":{"issn":["2041-8205"],"eissn":["2041-8213"]},"day":"10","status":"public","has_accepted_license":"1","publication_status":"published","external_id":{"arxiv":["2602.15935"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"JoMa"}],"article_processing_charge":"Yes","OA_type":"gold","file_date_updated":"2026-06-19T09:45:21Z"},{"date_created":"2026-06-14T22:01:42Z","article_number":"31","title":"A path to constraints on common envelope ejection in massive binaries: Full evolutionary reconstruction of three Black Hole X-ray binaries","author":[{"last_name":"Li","first_name":"Zhenwei","full_name":"Li, Zhenwei"},{"id":"5dd129bd-0601-11ef-b325-833284687b76","last_name":"Wei","full_name":"Wei, Dandan","first_name":"Dandan"},{"last_name":"Jia","full_name":"Jia, Shi","first_name":"Shi"},{"first_name":"Hailiang","full_name":"Chen, Hailiang","last_name":"Chen"},{"full_name":"Ge, Hongwei","first_name":"Hongwei","last_name":"Ge"},{"last_name":"Chen","full_name":"Chen, Zhuo","first_name":"Zhuo"},{"first_name":"Yangyang","full_name":"Zhang, Yangyang","last_name":"Zhang"},{"first_name":"Xuefei","full_name":"Chen, Xuefei","last_name":"Chen"},{"first_name":"Zhanwen","full_name":"Han, Zhanwen","last_name":"Han"}],"file":[{"file_size":3386217,"date_created":"2026-06-19T09:56:29Z","creator":"dernst","file_name":"2026_AstrophysicalJour_Li.pdf","file_id":"22099","access_level":"open_access","success":1,"content_type":"application/pdf","checksum":"bb76fbb51f8d2834cb79f19e7932e3bd","date_updated":"2026-06-19T09:56:29Z","relation":"main_file"}],"issue":"1","date_published":"2026-06-10T00:00:00Z","article_type":"original","publication":"The Astrophysical Journal","year":"2026","scopus_import":"1","volume":1004,"ddc":["520"],"doi":"10.3847/1538-4357/ae66fd","acknowledgement":"We deeply thank the referee for a very careful reading and constructive comments that have led to the improvement of the manuscript. The authors are grateful to Poshak Gandhi for his valuable suggestions and feedback on this work. This work is supported by the Natural Science Foundation of China (grant Nos. 12125303, 12525304, 12288102, 12473034, 12103028, 12333008, 12422305, 12090040/3, 12273105, 11703081, 11422324, 12073070, and 12173081), the CAS Project for Young Scientists in Basic Research (YSBR-148), the Strategic Priority Research Program of the Chinese Academy of Sciences (grant Nos. XDB1160303, XDB1160201, and XDB1160000), the National Key R&D Program of China (grant Nos. 2021YFA1600403 and 2021YFA1600400), the Key Research Program of Frontier Sciences of CAS (No. ZDBS-LY-7005), the “CAS Light of West China”, the Yunnan Revitalization Talent Support Program-Science & Technology Champion Project (No. 202305AB350003) and Young Talent Project, the International Centre of Supernovae (ICESUN), Yunnan Key Laboratory of Supernova Research (Nos. 202302AN360001 and 202201BC070003), Yunnan Fundamental Research Projects (No. 202401AT070139), and the Natural Science Foundation of Henan Province (No. 242300420944). X.C. acknowledges the New Cornerstone Science Foundation through the XPLORER PRIZE. The authors gratefully acknowledge the “PHOENIX Supercomputing Platform” jointly operated by the Binary Population Synthesis Group and the Stellar Astrophysics Group at Yunnan Observatories, Chinese Academy of Sciences.","intvolume":"      1004","external_id":{"arxiv":["2604.10440"]},"publication_status":"published","article_processing_charge":"Yes","department":[{"_id":"YlGo"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","day":"10","publication_identifier":{"issn":["0004-637X"],"eissn":["1538-4357"]},"has_accepted_license":"1","status":"public","file_date_updated":"2026-06-19T09:56:29Z","OA_type":"gold","oa":1,"month":"06","citation":{"ama":"Li Z, Wei D, Jia S, et al. A path to constraints on common envelope ejection in massive binaries: Full evolutionary reconstruction of three Black Hole X-ray binaries. <i>The Astrophysical Journal</i>. 2026;1004(1). doi:<a href=\"https://doi.org/10.3847/1538-4357/ae66fd\">10.3847/1538-4357/ae66fd</a>","ista":"Li Z, Wei D, Jia S, Chen H, Ge H, Chen Z, Zhang Y, Chen X, Han Z. 2026. A path to constraints on common envelope ejection in massive binaries: Full evolutionary reconstruction of three Black Hole X-ray binaries. The Astrophysical Journal. 1004(1), 31.","chicago":"Li, Zhenwei, Dandan Wei, Shi Jia, Hailiang Chen, Hongwei Ge, Zhuo Chen, Yangyang Zhang, Xuefei Chen, and Zhanwen Han. “A Path to Constraints on Common Envelope Ejection in Massive Binaries: Full Evolutionary Reconstruction of Three Black Hole X-Ray Binaries.” <i>The Astrophysical Journal</i>. IOP Publishing, 2026. <a href=\"https://doi.org/10.3847/1538-4357/ae66fd\">https://doi.org/10.3847/1538-4357/ae66fd</a>.","short":"Z. Li, D. Wei, S. Jia, H. Chen, H. Ge, Z. Chen, Y. Zhang, X. Chen, Z. Han, The Astrophysical Journal 1004 (2026).","apa":"Li, Z., Wei, D., Jia, S., Chen, H., Ge, H., Chen, Z., … Han, Z. (2026). A path to constraints on common envelope ejection in massive binaries: Full evolutionary reconstruction of three Black Hole X-ray binaries. <i>The Astrophysical Journal</i>. IOP Publishing. <a href=\"https://doi.org/10.3847/1538-4357/ae66fd\">https://doi.org/10.3847/1538-4357/ae66fd</a>","mla":"Li, Zhenwei, et al. “A Path to Constraints on Common Envelope Ejection in Massive Binaries: Full Evolutionary Reconstruction of Three Black Hole X-Ray Binaries.” <i>The Astrophysical Journal</i>, vol. 1004, no. 1, 31, IOP Publishing, 2026, doi:<a href=\"https://doi.org/10.3847/1538-4357/ae66fd\">10.3847/1538-4357/ae66fd</a>.","ieee":"Z. Li <i>et al.</i>, “A path to constraints on common envelope ejection in massive binaries: Full evolutionary reconstruction of three Black Hole X-ray binaries,” <i>The Astrophysical Journal</i>, vol. 1004, no. 1. IOP Publishing, 2026."},"type":"journal_article","_id":"21997","abstract":[{"text":"The massive binary common envelope (CE) phase plays a pivotal role in the formation of close black hole (BH)/neutron star binaries, yet significant uncertainties remain in our understanding of this process. In this study, we aim to constrain the massive binary CE phase by systematically reconstructing three observed BH X-ray binaries (BHXBs): GRO J1655-40, SAX J1819.3-2525, and 4U 1543-47. Through comprehensive binary evolution simulations and parametric supernova modeling, we establish lower limits for the CE efficiency parameters under different energy considerations within the standard energy formalism. Specifically, we derive minimum values for three cases: α0.5U and αU, representing CE efficiencies with half and all of the internal energy contributing to the envelope ejection, respectively, and αH, accounting for the envelope’s enthalpy. Our analysis reveals that the self-consistent formation of these three BHXBs requires CE efficiency parameters satisfying α0.5U ≳ 6.7, αU ≳ 4.2, and αH ≳ 1.7. Notably, we find no viable solutions with CE efficiency values below unity, even when considering the most extreme scenarios, in which the envelope binding energy is significantly reduced through enthalpy inclusion. Our results strongly imply that either additional energy sources are required or the formalism itself must be revised. Furthermore, we quantitatively assess the impact of BH natal kicks on our results. A key finding is that 4U 1543-47’s formation requires substantial natal kicks (≳50 km s−1), as lower kick velocities are incompatible with isolated binary evolution.","lang":"eng"}],"PlanS_conform":"1","OA_place":"publisher","DOAJ_listed":"1","arxiv":1,"language":[{"iso":"eng"}],"date_updated":"2026-06-19T09:58:52Z","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"quality_controlled":"1","publisher":"IOP Publishing","oa_version":"Published Version"}]