---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21484'
abstract:
- lang: eng
  text: An individual's phenotype reflects a complex interplay of the direct effects
    of their DNA, epigenetic modifications of their DNA induced by their parents,
    and indirect effects of their parents' DNA. Here, we derive how the genetic variance
    within a population is changed under the influence of indirect maternal, paternal
    and parent-of-origin effects under random mating. We also consider indirect effects
    of a sibling, in particular how the genetic variance is altered when looking at
    the phenotypic difference between two siblings. The calculations are then extended
    to include assortative mating (AM), which alters the variance by inducing increased
    homozygosity and correlations within and across loci. AM likely leads to covariance
    of parental genetic effects, a measure of the similarity of parents in the indirect
    effects they have on their children. We propose that this assortment for parental
    characteristics, where biological parents create similar environments for their
    children, can create shared parental effects across traits and the appearance
    of cross-trait AM. Our theory shows how the resemblance among relatives increases
    under both AM, indirect and parent-of-origin effects. When our model is used to
    predict correlations among relatives in human height, we find that explaining
    the patterns observed in real data requires both indirect genetic effects and
    assortative mating. The degree to which direct, indirect and epigenetic effects
    shape the phenotypic variance of complex traits remains an open question that
    requires large-scale family data to be resolved.
acknowledgement: We thank members of the Medical Genomics group at ISTA for their
  comments, which improved this manuscript. This work was funded by an SNSF Eccellenza
  Grant to MRR (PCEGP3-181181), and by core funding from the Institute of Science
  and Technology Austria.
article_number: iyag042
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Ilse
  full_name: Krätschmer, Ilse
  id: 30d4014e-7753-11eb-b44b-db6d61112e73
  last_name: Krätschmer
  orcid: 0000-0002-5636-9259
- first_name: Matthew Richard
  full_name: Robinson, Matthew Richard
  id: E5D42276-F5DA-11E9-8E24-6303E6697425
  last_name: Robinson
  orcid: 0000-0001-8982-8813
citation:
  ama: Krätschmer I, Robinson MR. A quantitative genetic model for indirect genetic
    effects and genomic imprinting under random and assortative mating. <i>Genetics</i>.
    2026. doi:<a href="https://doi.org/10.1093/genetics/iyag042">10.1093/genetics/iyag042</a>
  apa: Krätschmer, I., &#38; Robinson, M. R. (2026). A quantitative genetic model
    for indirect genetic effects and genomic imprinting under random and assortative
    mating. <i>Genetics</i>. Oxford University Press. <a href="https://doi.org/10.1093/genetics/iyag042">https://doi.org/10.1093/genetics/iyag042</a>
  chicago: Krätschmer, Ilse, and Matthew Richard Robinson. “A Quantitative Genetic
    Model for Indirect Genetic Effects and Genomic Imprinting under Random and Assortative
    Mating.” <i>Genetics</i>. Oxford University Press, 2026. <a href="https://doi.org/10.1093/genetics/iyag042">https://doi.org/10.1093/genetics/iyag042</a>.
  ieee: I. Krätschmer and M. R. Robinson, “A quantitative genetic model for indirect
    genetic effects and genomic imprinting under random and assortative mating,” <i>Genetics</i>.
    Oxford University Press, 2026.
  ista: Krätschmer I, Robinson MR. 2026. A quantitative genetic model for indirect
    genetic effects and genomic imprinting under random and assortative mating. Genetics.,
    iyag042.
  mla: Krätschmer, Ilse, and Matthew Richard Robinson. “A Quantitative Genetic Model
    for Indirect Genetic Effects and Genomic Imprinting under Random and Assortative
    Mating.” <i>Genetics</i>, iyag042, Oxford University Press, 2026, doi:<a href="https://doi.org/10.1093/genetics/iyag042">10.1093/genetics/iyag042</a>.
  short: I. Krätschmer, M.R. Robinson, Genetics (2026).
corr_author: '1'
date_created: 2026-03-23T15:02:54Z
date_published: 2026-02-12T00:00:00Z
date_updated: 2026-06-18T08:31:14Z
day: '12'
ddc:
- '570'
department:
- _id: MaRo
doi: 10.1093/genetics/iyag042
external_id:
  pmid:
  - '41677404'
has_accepted_license: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1093/genetics/iyag042
month: '02'
oa: 1
oa_version: Published Version
pmid: 1
publication: Genetics
publication_identifier:
  issn:
  - 1943-2631
publication_status: epub_ahead
publisher: Oxford University Press
quality_controlled: '1'
related_material:
  link:
  - relation: software
    url: https://github.com/medical-genomics-group/familyMC
status: public
title: A quantitative genetic model for indirect genetic effects and genomic imprinting
  under random and assortative mating
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '21502'
abstract:
- lang: eng
  text: The mammalian brain stores glucose, the main circulating energy substrate,
    as glycogen. In rodents, the cerebellum contains relatively high glycogen levels,
    yet its cellular and subcellular distribution remains poorly defined. Using monoclonal
    antibodies against glycogen, we examined its distribution in the mouse cerebellar
    cortex. Glycogen was predominantly localized to Bergmann glia (BG) processes in
    the molecular layer and was also detected in Purkinje cells (PCs), the principal
    cerebellar neurons. To assess the functional significance of cerebellar glycogen,
    we analyzed behavior in mice lacking glycogen synthase 1 (Gys1) in BG or PCs using
    a floxed Gys1 line. Gys1 deficiency in either PCs or GFAP-positive cells reduced
    anxiety-like behavior, whereas combined deletion caused PC degeneration and ataxia.
    These findings reveal a critical role for glycogen metabolism in both astrocytes
    and neurons in cerebellar function.
acknowledgement: This work was supported by the Novo Nordisk Foundation (NNFOC0058058,
  H. Hirase), the Danmarks Frie Forskningsfond (0134-00107B and 5283-00069A, H.Hirase),
  the Lundbeck Foundation, Japan Society for the Promotion of Science Grants-in-Aid
  for Scientific Research (KAKENHI) program (22K06454/24H01221, A.K.; 23K27482, H.Hirai),
  the Japan Agency for Medical Research and Development (AMED) Brain Mapping by Integrated
  Neurotechnologies for Disease Studies (Brain/MINDS) (JP21dm0207111, H. Hirai), AMED
  Brain/MINDS 2.0 (JP23wm0625001 and JP24wm0625103, H. Hirai), and grants from the
  Spanish Ministerio de Ciencia e Innovación (MCIU/FEDER/AEI) (PID2020-118699 GB-100,
  J.D.) and the Fundación Ramón Areces (J.D.). Sonam Akther has been supported by
  the RIKEN IPA fellowship. We are thankful to Dr. Yuki Oe for his support in the
  initial stage of this study and to Dan Xue for his help with the graphical abstract.
  We thank Dr. Pia Weikop for providing CTN research infrastructure. The authors declare
  no competing financial interests.
article_number: '115192'
article_processing_charge: Yes
article_type: original
author:
- first_name: Sonam
  full_name: Akther, Sonam
  last_name: Akther
- first_name: Ashley Bomin
  full_name: Lee, Ashley Bomin
  last_name: Lee
- first_name: Ayumu
  full_name: Konno, Ayumu
  last_name: Konno
- first_name: Antonis
  full_name: Asiminas, Antonis
  last_name: Asiminas
- first_name: Marta
  full_name: Vittani, Marta
  last_name: Vittani
- first_name: Tsuneko
  full_name: Mishima, Tsuneko
  last_name: Mishima
- first_name: Hirokazu
  full_name: Hirai, Hirokazu
  last_name: Hirai
- first_name: Claire Francesca
  full_name: Meehan, Claire Francesca
  last_name: Meehan
- first_name: Jordi
  full_name: Duran, Jordi
  last_name: Duran
- first_name: Joan
  full_name: Guinovart, Joan
  last_name: Guinovart
- first_name: Hitoshi
  full_name: Ashida, Hitoshi
  last_name: Ashida
- first_name: Tsuyoshi
  full_name: Morita, Tsuyoshi
  last_name: Morita
- first_name: Otto
  full_name: Baba, Otto
  last_name: Baba
- first_name: Ryuichi
  full_name: Shigemoto, Ryuichi
  id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
  last_name: Shigemoto
  orcid: 0000-0001-8761-9444
- first_name: Maiken
  full_name: Nedergaard, Maiken
  last_name: Nedergaard
- first_name: Hajime
  full_name: Hirase, Hajime
  last_name: Hirase
citation:
  ama: Akther S, Lee AB, Konno A, et al. Distribution and functional significance
    of rodent cerebellar glycogen. <i>iScience</i>. 2026;29(4). doi:<a href="https://doi.org/10.1016/j.isci.2026.115192">10.1016/j.isci.2026.115192</a>
  apa: Akther, S., Lee, A. B., Konno, A., Asiminas, A., Vittani, M., Mishima, T.,
    … Hirase, H. (2026). Distribution and functional significance of rodent cerebellar
    glycogen. <i>IScience</i>. Elsevier. <a href="https://doi.org/10.1016/j.isci.2026.115192">https://doi.org/10.1016/j.isci.2026.115192</a>
  chicago: Akther, Sonam, Ashley Bomin Lee, Ayumu Konno, Antonis Asiminas, Marta Vittani,
    Tsuneko Mishima, Hirokazu Hirai, et al. “Distribution and Functional Significance
    of Rodent Cerebellar Glycogen.” <i>IScience</i>. Elsevier, 2026. <a href="https://doi.org/10.1016/j.isci.2026.115192">https://doi.org/10.1016/j.isci.2026.115192</a>.
  ieee: S. Akther <i>et al.</i>, “Distribution and functional significance of rodent
    cerebellar glycogen,” <i>iScience</i>, vol. 29, no. 4. Elsevier, 2026.
  ista: Akther S, Lee AB, Konno A, Asiminas A, Vittani M, Mishima T, Hirai H, Meehan
    CF, Duran J, Guinovart J, Ashida H, Morita T, Baba O, Shigemoto R, Nedergaard
    M, Hirase H. 2026. Distribution and functional significance of rodent cerebellar
    glycogen. iScience. 29(4), 115192.
  mla: Akther, Sonam, et al. “Distribution and Functional Significance of Rodent Cerebellar
    Glycogen.” <i>IScience</i>, vol. 29, no. 4, 115192, Elsevier, 2026, doi:<a href="https://doi.org/10.1016/j.isci.2026.115192">10.1016/j.isci.2026.115192</a>.
  short: S. Akther, A.B. Lee, A. Konno, A. Asiminas, M. Vittani, T. Mishima, H. Hirai,
    C.F. Meehan, J. Duran, J. Guinovart, H. Ashida, T. Morita, O. Baba, R. Shigemoto,
    M. Nedergaard, H. Hirase, IScience 29 (2026).
date_created: 2026-03-29T22:07:07Z
date_published: 2026-03-17T00:00:00Z
date_updated: 2026-06-18T08:32:22Z
day: '17'
ddc:
- '570'
department:
- _id: RySh
doi: 10.1016/j.isci.2026.115192
external_id:
  pmid:
  - '41890976'
intvolume: '        29'
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1016/j.isci.2026.115192
month: '03'
oa: 1
oa_version: Published Version
pmid: 1
publication: iScience
publication_identifier:
  eissn:
  - 2589-0042
publication_status: epub_ahead
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Distribution and functional significance of rodent cerebellar glycogen
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 29
year: '2026'
...
---
OA_place: publisher
OA_type: gold
_id: '21436'
abstract:
- lang: eng
  text: 'The cobalt-intercalated transition metal dichalcogenide CoxTaS2 hosts a rich
    landscape of magnetic phases that depend sensitively on x. While the stoichiometric
    compound with x = 1/3 exhibits a single magnetic transition, samples with x≤0.325
    display two transitions with an anomalous Hall effect (AHE) emerging in the lower
    temperature phase. Here, we resolve the spin structure in each phase by employing
    a suite of magneto-optical probes that include the discovery of anomalous magneto-birefringence:
    a spontaneous time-reversal sensitive rotation of the principal optic axes. A
    symmetry-based analysis identifies the AHE-active phase as an anisotropic (2+1)Q
    state, in which magnetic modulation at one wavevector (Q) differs in symmetry
    from that at the remaining two. The (2+1)Q state naturally exhibits scalar spin
    chirality as a mechanism for the AHE and expands the classification of multi-Q
    magnetic phases.'
acknowledgement: 'We thank Linda Ye and Yue Sun for helpful discussion. Experimental
  and theoretical work at LBNL and UC Berkeley was funded by the Quantum Materials
  (KC2202) program under the U.S. Department of Energy, Office of Science, Office
  of Basic Energy Sciences, Materials Sciences and Engineering Division under Contract
  No. DE-AC02-05CH11231. V.S. and J.O. received support from the Gordon and Betty
  Moore Foundation’s EPiQS Initiative through Grant GBMF4537 to J.O. at UC Berkeley.
  J.K. received support from the National Science Foundation Graduate Research Fellowship
  Program under Grant No. 2146752. Any opinions, findings, and conclusions or recommendations
  expressed in this material are those of the author(s) and do not necessarily reflect
  the views of the National Science Foundation. During the preparation of this manuscript,
  we became aware of the following related work: refs. 56,57,58.'
article_number: '2507.12588'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Jonathon
  full_name: Kruppe, Jonathon
  last_name: Kruppe
- first_name: Josue
  full_name: Rodriguez, Josue
  last_name: Rodriguez
- first_name: Catherine
  full_name: Xu, Catherine
  last_name: Xu
- first_name: James
  full_name: Analytis, James
  last_name: Analytis
- first_name: Joseph
  full_name: Orenstein, Joseph
  last_name: Orenstein
- first_name: Veronika
  full_name: Sunko, Veronika
  id: 23cb1cf6-2c7a-11ef-91a4-f72fc19f20b3
  last_name: Sunko
  orcid: 0000-0003-2724-3523
citation:
  ama: Kruppe J, Rodriguez J, Xu C, Analytis J, Orenstein J, Sunko V. Anisotropic
    multi-Q order in CoxTaS2. <i>npj Quantum Materials</i>. 2026. doi:<a href="https://doi.org/10.1038/s41535-026-00856-w">10.1038/s41535-026-00856-w</a>
  apa: Kruppe, J., Rodriguez, J., Xu, C., Analytis, J., Orenstein, J., &#38; Sunko,
    V. (2026). Anisotropic multi-Q order in CoxTaS2. <i>Npj Quantum Materials</i>.
    Springer Nature. <a href="https://doi.org/10.1038/s41535-026-00856-w">https://doi.org/10.1038/s41535-026-00856-w</a>
  chicago: Kruppe, Jonathon, Josue Rodriguez, Catherine Xu, James Analytis, Joseph
    Orenstein, and Veronika Sunko. “Anisotropic Multi-Q Order in CoxTaS2.” <i>Npj
    Quantum Materials</i>. Springer Nature, 2026. <a href="https://doi.org/10.1038/s41535-026-00856-w">https://doi.org/10.1038/s41535-026-00856-w</a>.
  ieee: J. Kruppe, J. Rodriguez, C. Xu, J. Analytis, J. Orenstein, and V. Sunko, “Anisotropic
    multi-Q order in CoxTaS2,” <i>npj Quantum Materials</i>. Springer Nature, 2026.
  ista: Kruppe J, Rodriguez J, Xu C, Analytis J, Orenstein J, Sunko V. 2026. Anisotropic
    multi-Q order in CoxTaS2. npj Quantum Materials., 2507.12588.
  mla: Kruppe, Jonathon, et al. “Anisotropic Multi-Q Order in CoxTaS2.” <i>Npj Quantum
    Materials</i>, 2507.12588, Springer Nature, 2026, doi:<a href="https://doi.org/10.1038/s41535-026-00856-w">10.1038/s41535-026-00856-w</a>.
  short: J. Kruppe, J. Rodriguez, C. Xu, J. Analytis, J. Orenstein, V. Sunko, Npj
    Quantum Materials (2026).
corr_author: '1'
date_created: 2026-03-11T10:39:55Z
date_published: 2026-04-09T00:00:00Z
date_updated: 2026-06-18T08:32:52Z
day: '09'
ddc:
- '530'
department:
- _id: VeSu
doi: 10.1038/s41535-026-00856-w
external_id:
  arxiv:
  - '2507.12588'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1038/s41535-026-00856-w
month: '04'
oa: 1
oa_version: Published Version
publication: npj Quantum Materials
publication_identifier:
  eissn:
  - 2397-4648
publication_status: epub_ahead
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Anisotropic multi-Q order in CoxTaS2
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21986'
abstract:
- lang: eng
  text: Over the past two decades, molecular electronics has made significant progress
    toward discovering nanoscale analogues of conventional electronic components,
    largely enabled by the development of the scanning tunneling microscope-based
    break-junction (STM-BJ) technique. The STM-BJ technique enables precise and highly
    reproducible measurement of a molecule’s electronic transport properties, making
    it a powerful technique to explore physiochemical and electrochemical phenomena
    that are otherwise difficult to access. It has gained substantial popularity in
    the past 20 years, with experiments becoming increasingly diverse and sophisticated.
    Despite the wealth of literature, an accessible, practical guide to performing
    STM-BJ experiments and interpreting the data is largely absent. This tutorial
    includes a brief background into the development of STM-BJ measurements, followed
    by detailed explanations of instrumentation, data collection, statistical analysis,
    variations on standard experiments, and some troubleshooting methods. It is aimed
    at researchers looking to begin or improve STM-BJ studies in their laboratories,
    graduate students and postdoctoral researchers learning the technique, and readers
    seeking to critically evaluate the growing body of STM-BJ literature.
acknowledgement: We thank Michael Inkpen, Timothy Su, Masha Kamenetska, and Wanzhuo
  Shi for comments and Jyotisman Hazarika for data collection. This work was supported
  in part by the National Science Foundation (NSF-DMR 2241180) and by the Institute
  of Science and Technology Austria.
article_processing_charge: Yes
article_type: original
author:
- first_name: Emma
  full_name: York, Emma
  id: 08dde91e-8e0a-11f0-9d7d-9e8d80864f16
  last_name: York
- first_name: Latha
  full_name: Venkataraman, Latha
  id: 9ebb78a5-cc0d-11ee-8322-fae086a32caf
  last_name: Venkataraman
  orcid: 0000-0002-6957-6089
citation:
  ama: York E, Venkataraman L. Scanning tunneling microscope-based break-junction
    technique - A tutorial. <i>ACS Physical Chemistry Au</i>. 2026;6(3):408-424. doi:<a
    href="https://doi.org/10.1021/acsphyschemau.6c00026">10.1021/acsphyschemau.6c00026</a>
  apa: York, E., &#38; Venkataraman, L. (2026). Scanning tunneling microscope-based
    break-junction technique - A tutorial. <i>ACS Physical Chemistry Au</i>. American
    Chemical Society. <a href="https://doi.org/10.1021/acsphyschemau.6c00026">https://doi.org/10.1021/acsphyschemau.6c00026</a>
  chicago: York, Emma, and Latha Venkataraman. “Scanning Tunneling Microscope-Based
    Break-Junction Technique - A Tutorial.” <i>ACS Physical Chemistry Au</i>. American
    Chemical Society, 2026. <a href="https://doi.org/10.1021/acsphyschemau.6c00026">https://doi.org/10.1021/acsphyschemau.6c00026</a>.
  ieee: E. York and L. Venkataraman, “Scanning tunneling microscope-based break-junction
    technique - A tutorial,” <i>ACS Physical Chemistry Au</i>, vol. 6, no. 3. American
    Chemical Society, pp. 408–424, 2026.
  ista: York E, Venkataraman L. 2026. Scanning tunneling microscope-based break-junction
    technique - A tutorial. ACS Physical Chemistry Au. 6(3), 408–424.
  mla: York, Emma, and Latha Venkataraman. “Scanning Tunneling Microscope-Based Break-Junction
    Technique - A Tutorial.” <i>ACS Physical Chemistry Au</i>, vol. 6, no. 3, American
    Chemical Society, 2026, pp. 408–24, doi:<a href="https://doi.org/10.1021/acsphyschemau.6c00026">10.1021/acsphyschemau.6c00026</a>.
  short: E. York, L. Venkataraman, ACS Physical Chemistry Au 6 (2026) 408–424.
corr_author: '1'
date_created: 2026-06-10T07:38:41Z
date_published: 2026-05-04T00:00:00Z
date_updated: 2026-06-19T06:35:58Z
day: '04'
ddc:
- '540'
department:
- _id: LaVe
doi: 10.1021/acsphyschemau.6c00026
external_id:
  pmid:
  - '42221941'
file:
- access_level: open_access
  checksum: 1dc16bdfb1c1cd3acde802f4350cb42a
  content_type: application/pdf
  creator: dernst
  date_created: 2026-06-19T06:31:16Z
  date_updated: 2026-06-19T06:31:16Z
  file_id: '22020'
  file_name: 2026_ACSPhysChem_York.pdf
  file_size: 11251172
  relation: main_file
  success: 1
file_date_updated: 2026-06-19T06:31:16Z
has_accepted_license: '1'
intvolume: '         6'
issue: '3'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
page: 408-424
pmid: 1
publication: ACS Physical Chemistry Au
publication_identifier:
  eissn:
  - 2694-2445
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Scanning tunneling microscope-based break-junction technique - A tutorial
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 6
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '21987'
abstract:
- lang: eng
  text: 'We introduce JODIE, a genetic joint modeling approach that estimates how
    DNA loci influence human traits by partitioning genetic effects into four components:
    direct effects (from a child’s alleles), indirect maternal and paternal effects
    (from parents’ alleles), and parent-of-origin (PofO) effects (dependent on parental
    transmission of alleles), while uniquely accounting for assortative mating. We
    analyze 30,000 child-mother-father trios from the Estonian Biobank and the Norwegian
    Mother, Father, and Child Cohort, focusing on height, body mass index, and childhood
    educational test scores. We find direct effects to be the largest contributor
    to trait variation, but combined, indirect parental and PofO effects are similarly
    substantial. We support our results by within-family genome-wide association testing
    and identify 276 independently associated DNA regions with a complex interplay
    between direct, indirect, and PofO effects. By joint modeling, we show that direct,
    indirect, and PofO effects collectively shape human phenotypic variation across
    loci genome-wide.'
acknowledged_ssus:
- _id: ScienComp
acknowledgement: "We thank Zoltan Kutalik, Peter Visscher, and members of the Robinson
  group at ISTA for their comments, which improved this manuscript. This work was
  funded by an SNSF Eccellenza Grant to M.R.R. (PCEGP3-181181) and by core funding
  from the Institute of Science and Technology Austria.\r\nThe Norwegian Mother, Father,
  and Child Cohort Study is supported by the Norwegian Ministry of Health and Care
  Services and the Ministry of Education and Research. We are grateful to all the
  participating families in Norway who take part in this on-going cohort study. We
  thank the Norwegian Institute of Public Health (NIPH) for generating high-quality
  genomic data. The research is part of the HARVEST collaboration, supported by the
  Research Council of Norway (#229624). We also thank the NORMENT Center for providing
  genotype data, funded by the Research Council of Norway (#223273), South East Norway
  Health Authorities, and Stiftelsen Kristian Gerhard Jebsen, and in collaboration
  with deCODE Genetics. We further thank the Center for Diabetes Research, the University
  of Bergen for providing genotype data funded by the ERC AdG project SELECTionPREDISPOSED,
  Stiftelsen Kristian Gerhard Jebsen, Trond Mohn Foundation, the Research Council
  of Norway, the Novo Nordisk Foundation, the University of Bergen, and the Western
  Norway Health Authorities. The MoBa work was performed on the TSD (Tjeneste for
  Sensitive Data) facilities, owned by the University of Oslo, operated and developed
  by the TSD service group at the University of Oslo, IT Department (USIT, tsd-drift@usit.uio.no).
  E.Y. is supported by the European Union (grant numbers 101045526 and 101073237)
  and the Research Council of Norway (grant numbers 336078, 288083, and 331640).\r\nWe
  would like to acknowledge the participants and investigators of the Generation Scotland
  Cohort study. Generation Scotland received core support from the Chief Scientist
  Office of the Scottish Government Health Directorates (CZD/16/6) and the Scottish
  Funding Council (HR03006). Genotyping and methylation typing of the GS:SFHS samples
  was carried out by the Genetics Core Laboratory at the Wellcome Trust Clinical Research
  Facility, Edinburgh, Scotland and was funded by the Medical Research Council UK
  and the Wellcome Trust (Wellcome Trust Strategic Award “STratifying Resilience and
  Depression Longitudinally” [STRADL] ref. 104036/Z/14/Z).\r\nWe would like to thank
  and acknowledge the participants and investigators of the Estonian Biobank (EstBB)
  study. The research was conducted using the Estonian Center of Genomics/Roadmap
  II funded by the Estonian Research Council (project number TT17).\r\nNorwegian analyses
  were performed on resources provided by Sigma2 - the National Infrastructure for
  High-Performance Computing and Data Storage in Norway. Estonian Data analysis was
  carried out in the High-Performance Computing Center cloud provided by University
  of Tartu. Analysis of the Generation Scotland data and the summary statistics obtained
  from the other analyses was conducted at IST Austria and is supported by the Scientific
  Service Units (SSU) of IST Austria through resources provided by Scientific Computing
  (SciComp)."
article_number: '101277'
article_processing_charge: Yes
article_type: original
author:
- first_name: Ilse
  full_name: Krätschmer, Ilse
  id: 30d4014e-7753-11eb-b44b-db6d61112e73
  last_name: Krätschmer
  orcid: 0000-0002-5636-9259
- first_name: Laura
  full_name: Hegemann, Laura
  last_name: Hegemann
- first_name: Robin J.
  full_name: Hofmeister, Robin J.
  last_name: Hofmeister
- first_name: Elizabeth C.
  full_name: Corfield, Elizabeth C.
  last_name: Corfield
- first_name: Mahdi
  full_name: Mahmoudi, Mahdi
  last_name: Mahmoudi
- first_name: Olivier
  full_name: Delaneau, Olivier
  last_name: Delaneau
- first_name: Ole A.
  full_name: Andreassen, Ole A.
  last_name: Andreassen
- first_name: Archie
  full_name: Campbell, Archie
  last_name: Campbell
- first_name: Caroline
  full_name: Hayward, Caroline
  last_name: Hayward
- first_name: Riccardo E.
  full_name: Marioni, Riccardo E.
  last_name: Marioni
- first_name: Eivind
  full_name: Ystrom, Eivind
  last_name: Ystrom
- first_name: Alexandra
  full_name: Havdahl, Alexandra
  last_name: Havdahl
- first_name: Matthew Richard
  full_name: Robinson, Matthew Richard
  id: E5D42276-F5DA-11E9-8E24-6303E6697425
  last_name: Robinson
  orcid: 0000-0001-8982-8813
citation:
  ama: Krätschmer I, Hegemann L, Hofmeister RJ, et al. Separating direct, indirect,
    and parent-of-origin genetic effects in the human population. <i>Cell Genomics</i>.
    doi:<a href="https://doi.org/10.1016/j.xgen.2026.101277">10.1016/j.xgen.2026.101277</a>
  apa: Krätschmer, I., Hegemann, L., Hofmeister, R. J., Corfield, E. C., Mahmoudi,
    M., Delaneau, O., … Robinson, M. R. (n.d.). Separating direct, indirect, and parent-of-origin
    genetic effects in the human population. <i>Cell Genomics</i>. Elsevier. <a href="https://doi.org/10.1016/j.xgen.2026.101277">https://doi.org/10.1016/j.xgen.2026.101277</a>
  chicago: Krätschmer, Ilse, Laura Hegemann, Robin J. Hofmeister, Elizabeth C. Corfield,
    Mahdi Mahmoudi, Olivier Delaneau, Ole A. Andreassen, et al. “Separating Direct,
    Indirect, and Parent-of-Origin Genetic Effects in the Human Population.” <i>Cell
    Genomics</i>. Elsevier, n.d. <a href="https://doi.org/10.1016/j.xgen.2026.101277">https://doi.org/10.1016/j.xgen.2026.101277</a>.
  ieee: I. Krätschmer <i>et al.</i>, “Separating direct, indirect, and parent-of-origin
    genetic effects in the human population,” <i>Cell Genomics</i>. Elsevier.
  ista: Krätschmer I, Hegemann L, Hofmeister RJ, Corfield EC, Mahmoudi M, Delaneau
    O, Andreassen OA, Campbell A, Hayward C, Marioni RE, Ystrom E, Havdahl A, Robinson
    MR. Separating direct, indirect, and parent-of-origin genetic effects in the human
    population. Cell Genomics., 101277.
  mla: Krätschmer, Ilse, et al. “Separating Direct, Indirect, and Parent-of-Origin
    Genetic Effects in the Human Population.” <i>Cell Genomics</i>, 101277, Elsevier,
    doi:<a href="https://doi.org/10.1016/j.xgen.2026.101277">10.1016/j.xgen.2026.101277</a>.
  short: I. Krätschmer, L. Hegemann, R.J. Hofmeister, E.C. Corfield, M. Mahmoudi,
    O. Delaneau, O.A. Andreassen, A. Campbell, C. Hayward, R.E. Marioni, E. Ystrom,
    A. Havdahl, M.R. Robinson, Cell Genomics (n.d.).
corr_author: '1'
date_created: 2026-06-10T07:39:08Z
date_published: 2026-06-09T00:00:00Z
date_updated: 2026-06-19T07:00:47Z
day: '09'
department:
- _id: MaRo
doi: 10.1016/j.xgen.2026.101277
external_id:
  pmid:
  - '40909755'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1016/j.xgen.2026.101277
month: '06'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 9B8D11D6-BA93-11EA-9121-9846C619BF3A
  grant_number: PCEGP3_181181
  name: Improving estimation and prediction of common complex disease risk
publication: Cell Genomics
publication_identifier:
  eissn:
  - 2666-979X
publication_status: inpress
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Separating direct, indirect, and parent-of-origin genetic effects in the human
  population
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
OA_place: repository
OA_type: green
_id: '21994'
abstract:
- lang: eng
  text: Adaptive plant development is orchestrated, among others, by directional,
    intercellular transport of the phytohormone auxin. Self-organizing development,
    such as flexible vasculature formation, depends on so-called auxin canalization,
    manifested by the gradual formation of auxin transport channels through feedback
    between auxin signalling and transport. Herein, we identify MAKR6 as an important,
    novel component in this feedback. MAKR6 expression accumulates strongly in vascular
    cells and is tightly regulated by auxin via the Aux/IAA-ARF-WRKY23 transcriptional
    network. MAKR6 is required for auxin canalization-dependent processes, including
    leaf venation, vasculature regeneration, and de novo auxin channel formation from
    local auxin sources. Mechanistically, MAKR6 interacts with the PIN1 auxin transporter,
    modulating its trafficking and polarization. MAKR6 also associates with and integrates
    two key receptor-like kinase complexes involved in canalization, TMK1/4 and the
    CAMEL-CANAR. Together, our study establishes MAKR6 as a multifaceted regulator
    that couples transcriptional auxin signalling to PIN1 repolarization and coordinates
    multiple RLK-mediated signalling pathways during canalization. This provides mechanistic
    insights into auxin canalization and exemplifies a framework for exploring similar
    regulatory nodes in other developmental contexts.
acknowledgement: 'We would like to thank Dr. Yvon Jaillais (ENS, Lyon) for sharing
  MAKR2 materials. This research was supported by the Scientific Service Units (SSU)
  of ISTA through resources provided by the Imaging & Optics Facility (IOF) and the
  Lab Support Facility (LSF). The research in the Friml group leading to these results
  was funded by the European Research Council (ERC): 101142681 CYNIPS; and the Austrian
  Science Fund (FWF): I 6123-B and P 37051-B. Ewa Mazur was supported by the National
  Science Centre (NCN), Poland, under the OPUS call in the WEAVE programme: 2021/43/I/NZ1/01835.'
article_processing_charge: No
author:
- first_name: Zengxiang
  full_name: Ge, Zengxiang
  id: f43371a3-09ff-11eb-8013-bd0c6a2f6de8
  last_name: Ge
  orcid: 0000-0001-9381-3577
- first_name: Lilla
  full_name: Koczka, Lilla
  last_name: Koczka
- first_name: Ewa
  full_name: Mazur, Ewa
  last_name: Mazur
- first_name: Gergely
  full_name: Molnar, Gergely
  id: 34F1AF46-F248-11E8-B48F-1D18A9856A87
  last_name: Molnar
- first_name: Dmitrii
  full_name: Vladimirtsev, Dmitrii
  id: 60466724-5355-11ee-ae5a-fa55e8f99c3d
  last_name: Vladimirtsev
- first_name: Nada
  full_name: Kassem, Nada
  last_name: Kassem
- first_name: Sara
  full_name: Ait Ikene, Sara
  id: 6a0bb896-6bad-11f1-9bef-906e9eb76034
  last_name: Ait Ikene
- first_name: Lukas
  full_name: Fiedler, Lukas
  id: 7c417475-8972-11ed-ae7b-8b674ca26986
  last_name: Fiedler
- first_name: Jiří
  full_name: Friml, Jiří
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
citation:
  ama: Ge Z, Koczka L, Mazur E, et al. MAKR6 integrates TMK and CAMEL/CANAR signalling
    for auxin canalization in Arabidopsis. <i>bioRxiv</i>. doi:<a href="https://doi.org/10.1101/2025.10.07.680881">10.1101/2025.10.07.680881</a>
  apa: Ge, Z., Koczka, L., Mazur, E., Molnar, G., Vladimirtsev, D., Kassem, N., …
    Friml, J. (n.d.). MAKR6 integrates TMK and CAMEL/CANAR signalling for auxin canalization
    in Arabidopsis. <i>bioRxiv</i>. <a href="https://doi.org/10.1101/2025.10.07.680881">https://doi.org/10.1101/2025.10.07.680881</a>
  chicago: Ge, Zengxiang, Lilla Koczka, Ewa Mazur, Gergely Molnar, Dmitrii Vladimirtsev,
    Nada Kassem, Sara Ait Ikene, Lukas Fiedler, and Jiří Friml. “MAKR6 Integrates
    TMK and CAMEL/CANAR Signalling for Auxin Canalization in Arabidopsis.” <i>BioRxiv</i>,
    n.d. <a href="https://doi.org/10.1101/2025.10.07.680881">https://doi.org/10.1101/2025.10.07.680881</a>.
  ieee: Z. Ge <i>et al.</i>, “MAKR6 integrates TMK and CAMEL/CANAR signalling for
    auxin canalization in Arabidopsis,” <i>bioRxiv</i>. .
  ista: Ge Z, Koczka L, Mazur E, Molnar G, Vladimirtsev D, Kassem N, Ait Ikene S,
    Fiedler L, Friml J. MAKR6 integrates TMK and CAMEL/CANAR signalling for auxin
    canalization in Arabidopsis. bioRxiv, <a href="https://doi.org/10.1101/2025.10.07.680881">10.1101/2025.10.07.680881</a>.
  mla: Ge, Zengxiang, et al. “MAKR6 Integrates TMK and CAMEL/CANAR Signalling for
    Auxin Canalization in Arabidopsis.” <i>BioRxiv</i>, doi:<a href="https://doi.org/10.1101/2025.10.07.680881">10.1101/2025.10.07.680881</a>.
  short: Z. Ge, L. Koczka, E. Mazur, G. Molnar, D. Vladimirtsev, N. Kassem, S. Ait
    Ikene, L. Fiedler, J. Friml, BioRxiv (n.d.).
corr_author: '1'
date_created: 2026-06-13T16:57:07Z
date_published: 2026-05-30T00:00:00Z
date_updated: 2026-06-19T07:14:01Z
day: '30'
ddc:
- '580'
department:
- _id: GradSch
- _id: JiFr
doi: 10.1101/2025.10.07.680881
has_accepted_license: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1101/2025.10.07.680881
month: '05'
oa: 1
oa_version: Preprint
project:
- _id: 8f347782-16d5-11f0-9cad-8c19706ee739
  grant_number: '101142681'
  name: Cyclic nucleotides as second messengers in plants
- _id: bd76d395-d553-11ed-ba76-f678c14f9033
  grant_number: I06123
  name: Peptide receptors for auxin canalization in Arabidopsis
- _id: 7bcece63-9f16-11ee-852c-ae94e099eeb6
  grant_number: P37051
  name: Guanylate cyclase activity of TIR1/AFBs auxin receptors
publication: bioRxiv
publication_status: submitted
scopus_import: '1'
status: public
title: MAKR6 integrates TMK and CAMEL/CANAR signalling for auxin canalization in Arabidopsis
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21998'
abstract:
- lang: eng
  text: Little Red Dots (LRDs), among the most enigmatic high-redshift discoveries
    by JWST, are commonly believed to be powered by accreting supermassive black holes.
    Here, we explore the possibility that these sources are globular clusters in formation,
    with rest-frame UV arising from a very young stellar population and rest-frame
    optical from a short-lived supermassive (>104 M⊙) star. The spectral profiles
    of LRDs are broadly consistent with this scenario, though the observed temperatures
    and bolometric luminosities favor emission reprocessed by optically thick continuum-driven
    winds not fully captured by current models. The LRD z ∼ 5−7 UV luminosity function
    naturally evolves, under standard evolutionary and mass-loss prescriptions, into
    a present-day mass function with a turnover at log10(M*/M⊙) = 5.3 and an exponential
    cutoff at high masses, consistent with local globular cluster populations. We
    estimate the total present-day number density of LRDs formed across all redshifts
    to be ≈0.3 Mpc−3, similar within uncertainties to local globular clusters. The
    observed LRD redshift range matches the age distribution of metal-poor globular
    clusters, without current LRD counterparts to the metal-rich population. If LRDs
    are globular clusters in formation, we predict chemical abundance patterns characteristic
    of multiple stellar populations, including enhanced He and N, and potential Na–O
    and Al–Mg anticorrelations. These results offer a local perspective to explore
    this surprisingly abundant population of distant sources, and a potential new
    window into extreme stellar astrophysics in the early Universe.
acknowledgement: "We thank the referees for detailed and highly constructive reports
  that significantly improved the scope and breadth of the manuscript. J.C. thanks
  Hollis Akins, Volker Bromm, Rui Chaves-Marques, Steve Finkelstein, Karl Gebhardt,
  Keith Hawkins, Harley Katz, Stellar Offner, Daniel Schaerer, Grace Telford, and
  Jorick Vink for conversations that improved the Letter. A.d.G. acknowledges support
  from a Clay Fellowship awarded by the Smithsonian Astrophysical Observatory. M.B.K.
  acknowledges support from NSF grants AST-2108962 and AST-2408247; NASA grant 80NSSC22K0827;
  HST-GO-16686, HST-AR-17028, JWST-GO-03788, and JWST-AR-06278 from the Space Telescope
  Science Institute, which is operated by AURA, Inc., under NASA contract NAS5-26555;
  and from the Samuel T. and Fern Yanagisawa Regents Professorship in Astronomy at
  UT Austin. A.A.C.S. acknowledges support by the Deutsche Forschungsgemeinschaft
  (DFG, German Research Foundation) in the form of an Emmy Noether Research Group—Project-ID
  445674056 (SA4064/1-1, PI Sander). A.A.C.S. further acknowledges support from the
  Deutsches Zentrum für Luft und Raumfahrt (DLR) grant grants 50 OR 2509 (PI: A.A.C.
  Sander) and 50 OR 2306 (PI: V. Ramachandran/A.A.C. Sander) as well as from the Federal
  Ministry of Research, Technology, and Space (BMFTR) and the Baden-Württemberg Ministry
  of Science as part of the Excellence Strategy of the German Federal and State Governments.
  This project was cofunded by the European Union (Project 101183150—OCEANS).\r\n\r\nThis
  work is based in part on observations made with the NASA/ESA/CSA James Webb Space
  Telescope. The data were obtained from the Mikulski Archive for Space Telescopes
  at the Space Telescope Science Institute, which is operated by the Association of
  Universities for Research in Astronomy, Inc., under NASA contract NAS 5-03127 for
  JWST. These observations are associated with programs 1180, 1181, 1208, 1212, 1213,
  1215, 1286, 1345, 1433, 2198, 2561, 2750, 2767, 4106, 4233, 5105, 5224, 6368, and
  6585."
article_number: L4
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: John
  full_name: Chisholm, John
  last_name: Chisholm
- first_name: Danielle A.
  full_name: Berg, Danielle A.
  last_name: Berg
- first_name: Michael
  full_name: Boylan-Kolchin, Michael
  last_name: Boylan-Kolchin
- first_name: Anna
  full_name: De Graaff, Anna
  last_name: De Graaff
- first_name: Lukas J.
  full_name: Furtak, Lukas J.
  last_name: Furtak
- first_name: Vasily
  full_name: Kokorev, Vasily
  last_name: Kokorev
- first_name: Jorryt J
  full_name: Matthee, Jorryt J
  id: 7439a258-f3c0-11ec-9501-9df22fe06720
  last_name: Matthee
  orcid: 0000-0003-2871-127X
- first_name: Julian B.
  full_name: Muñoz, Julian B.
  last_name: Muñoz
- first_name: Rohan P.
  full_name: Naidu, Rohan P.
  last_name: Naidu
- first_name: Andreas A.C.
  full_name: Sander, Andreas A.C.
  last_name: Sander
citation:
  ama: Chisholm J, Berg DA, Boylan-Kolchin M, et al. Little Red Dots as globular clusters
    in formation. <i>The Astrophysical Journal Letters</i>. 2026;1004(1). doi:<a href="https://doi.org/10.3847/2041-8213/ae6dae">10.3847/2041-8213/ae6dae</a>
  apa: Chisholm, J., Berg, D. A., Boylan-Kolchin, M., De Graaff, A., Furtak, L. J.,
    Kokorev, V., … Sander, A. A. C. (2026). Little Red Dots as globular clusters in
    formation. <i>The Astrophysical Journal Letters</i>. IOP Publishing. <a href="https://doi.org/10.3847/2041-8213/ae6dae">https://doi.org/10.3847/2041-8213/ae6dae</a>
  chicago: Chisholm, John, Danielle A. Berg, Michael Boylan-Kolchin, Anna De Graaff,
    Lukas J. Furtak, Vasily Kokorev, Jorryt J Matthee, Julian B. Muñoz, Rohan P. Naidu,
    and Andreas A.C. Sander. “Little Red Dots as Globular Clusters in Formation.”
    <i>The Astrophysical Journal Letters</i>. IOP Publishing, 2026. <a href="https://doi.org/10.3847/2041-8213/ae6dae">https://doi.org/10.3847/2041-8213/ae6dae</a>.
  ieee: J. Chisholm <i>et al.</i>, “Little Red Dots as globular clusters in formation,”
    <i>The Astrophysical Journal Letters</i>, vol. 1004, no. 1. IOP Publishing, 2026.
  ista: Chisholm J, Berg DA, Boylan-Kolchin M, De Graaff A, Furtak LJ, Kokorev V,
    Matthee JJ, Muñoz JB, Naidu RP, Sander AAC. 2026. Little Red Dots as globular
    clusters in formation. The Astrophysical Journal Letters. 1004(1), L4.
  mla: Chisholm, John, et al. “Little Red Dots as Globular Clusters in Formation.”
    <i>The Astrophysical Journal Letters</i>, vol. 1004, no. 1, L4, IOP Publishing,
    2026, doi:<a href="https://doi.org/10.3847/2041-8213/ae6dae">10.3847/2041-8213/ae6dae</a>.
  short: J. Chisholm, D.A. Berg, M. Boylan-Kolchin, A. De Graaff, L.J. Furtak, V.
    Kokorev, J.J. Matthee, J.B. Muñoz, R.P. Naidu, A.A.C. Sander, The Astrophysical
    Journal Letters 1004 (2026).
date_created: 2026-06-14T22:01:42Z
date_published: 2026-06-10T00:00:00Z
date_updated: 2026-06-19T09:50:33Z
day: '10'
ddc:
- '520'
department:
- _id: JoMa
doi: 10.3847/2041-8213/ae6dae
external_id:
  arxiv:
  - '2602.15935'
file:
- access_level: open_access
  checksum: 66949af6e620c8ef37de42688829a3e3
  content_type: application/pdf
  creator: dernst
  date_created: 2026-06-19T09:45:21Z
  date_updated: 2026-06-19T09:45:21Z
  file_id: '22098'
  file_name: 2026_AstrophysicalJourLetters_Chisholm.pdf
  file_size: 919919
  relation: main_file
  success: 1
file_date_updated: 2026-06-19T09:45:21Z
has_accepted_license: '1'
intvolume: '      1004'
issue: '1'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
publication: The Astrophysical Journal Letters
publication_identifier:
  eissn:
  - 2041-8213
  issn:
  - 2041-8205
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: Little Red Dots as globular clusters in formation
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 1004
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21997'
abstract:
- lang: eng
  text: 'The massive binary common envelope (CE) phase plays a pivotal role in the
    formation of close black hole (BH)/neutron star binaries, yet significant uncertainties
    remain in our understanding of this process. In this study, we aim to constrain
    the massive binary CE phase by systematically reconstructing three observed BH
    X-ray binaries (BHXBs): GRO J1655-40, SAX J1819.3-2525, and 4U 1543-47. Through
    comprehensive binary evolution simulations and parametric supernova modeling,
    we establish lower limits for the CE efficiency parameters under different energy
    considerations within the standard energy formalism. Specifically, we derive minimum
    values for three cases: α0.5U and αU, representing CE efficiencies with half and
    all of the internal energy contributing to the envelope ejection, respectively,
    and αH, accounting for the envelope’s enthalpy. Our analysis reveals that the
    self-consistent formation of these three BHXBs requires CE efficiency parameters
    satisfying α0.5U ≳ 6.7, αU ≳ 4.2, and αH ≳ 1.7. Notably, we find no viable solutions
    with CE efficiency values below unity, even when considering the most extreme
    scenarios, in which the envelope binding energy is significantly reduced through
    enthalpy inclusion. Our results strongly imply that either additional energy sources
    are required or the formalism itself must be revised. Furthermore, we quantitatively
    assess the impact of BH natal kicks on our results. A key finding is that 4U 1543-47’s
    formation requires substantial natal kicks (≳50 km s−1), as lower kick velocities
    are incompatible with isolated binary evolution.'
acknowledgement: We deeply thank the referee for a very careful reading and constructive
  comments that have led to the improvement of the manuscript. The authors are grateful
  to Poshak Gandhi for his valuable suggestions and feedback on this work. This work
  is supported by the Natural Science Foundation of China (grant Nos. 12125303, 12525304,
  12288102, 12473034, 12103028, 12333008, 12422305, 12090040/3, 12273105, 11703081,
  11422324, 12073070, and 12173081), the CAS Project for Young Scientists in Basic
  Research (YSBR-148), the Strategic Priority Research Program of the Chinese Academy
  of Sciences (grant Nos. XDB1160303, XDB1160201, and XDB1160000), the National Key
  R&D Program of China (grant Nos. 2021YFA1600403 and 2021YFA1600400), the Key Research
  Program of Frontier Sciences of CAS (No. ZDBS-LY-7005), the “CAS Light of West China”,
  the Yunnan Revitalization Talent Support Program-Science & Technology Champion Project
  (No. 202305AB350003) and Young Talent Project, the International Centre of Supernovae
  (ICESUN), Yunnan Key Laboratory of Supernova Research (Nos. 202302AN360001 and 202201BC070003),
  Yunnan Fundamental Research Projects (No. 202401AT070139), and the Natural Science
  Foundation of Henan Province (No. 242300420944). X.C. acknowledges the New Cornerstone
  Science Foundation through the XPLORER PRIZE. The authors gratefully acknowledge
  the “PHOENIX Supercomputing Platform” jointly operated by the Binary Population
  Synthesis Group and the Stellar Astrophysics Group at Yunnan Observatories, Chinese
  Academy of Sciences.
article_number: '31'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Zhenwei
  full_name: Li, Zhenwei
  last_name: Li
- first_name: Dandan
  full_name: Wei, Dandan
  id: 5dd129bd-0601-11ef-b325-833284687b76
  last_name: Wei
- first_name: Shi
  full_name: Jia, Shi
  last_name: Jia
- first_name: Hailiang
  full_name: Chen, Hailiang
  last_name: Chen
- first_name: Hongwei
  full_name: Ge, Hongwei
  last_name: Ge
- first_name: Zhuo
  full_name: Chen, Zhuo
  last_name: Chen
- first_name: Yangyang
  full_name: Zhang, Yangyang
  last_name: Zhang
- first_name: Xuefei
  full_name: Chen, Xuefei
  last_name: Chen
- first_name: Zhanwen
  full_name: Han, Zhanwen
  last_name: Han
citation:
  ama: 'Li Z, Wei D, Jia S, et al. A path to constraints on common envelope ejection
    in massive binaries: Full evolutionary reconstruction of three Black Hole X-ray
    binaries. <i>The Astrophysical Journal</i>. 2026;1004(1). doi:<a href="https://doi.org/10.3847/1538-4357/ae66fd">10.3847/1538-4357/ae66fd</a>'
  apa: 'Li, Z., Wei, D., Jia, S., Chen, H., Ge, H., Chen, Z., … Han, Z. (2026). A
    path to constraints on common envelope ejection in massive binaries: Full evolutionary
    reconstruction of three Black Hole X-ray binaries. <i>The Astrophysical Journal</i>.
    IOP Publishing. <a href="https://doi.org/10.3847/1538-4357/ae66fd">https://doi.org/10.3847/1538-4357/ae66fd</a>'
  chicago: 'Li, Zhenwei, Dandan Wei, Shi Jia, Hailiang Chen, Hongwei Ge, Zhuo Chen,
    Yangyang Zhang, Xuefei Chen, and Zhanwen Han. “A Path to Constraints on Common
    Envelope Ejection in Massive Binaries: Full Evolutionary Reconstruction of Three
    Black Hole X-Ray Binaries.” <i>The Astrophysical Journal</i>. IOP Publishing,
    2026. <a href="https://doi.org/10.3847/1538-4357/ae66fd">https://doi.org/10.3847/1538-4357/ae66fd</a>.'
  ieee: 'Z. Li <i>et al.</i>, “A path to constraints on common envelope ejection in
    massive binaries: Full evolutionary reconstruction of three Black Hole X-ray binaries,”
    <i>The Astrophysical Journal</i>, vol. 1004, no. 1. IOP Publishing, 2026.'
  ista: 'Li Z, Wei D, Jia S, Chen H, Ge H, Chen Z, Zhang Y, Chen X, Han Z. 2026. A
    path to constraints on common envelope ejection in massive binaries: Full evolutionary
    reconstruction of three Black Hole X-ray binaries. The Astrophysical Journal.
    1004(1), 31.'
  mla: 'Li, Zhenwei, et al. “A Path to Constraints on Common Envelope Ejection in
    Massive Binaries: Full Evolutionary Reconstruction of Three Black Hole X-Ray Binaries.”
    <i>The Astrophysical Journal</i>, vol. 1004, no. 1, 31, IOP Publishing, 2026,
    doi:<a href="https://doi.org/10.3847/1538-4357/ae66fd">10.3847/1538-4357/ae66fd</a>.'
  short: Z. Li, D. Wei, S. Jia, H. Chen, H. Ge, Z. Chen, Y. Zhang, X. Chen, Z. Han,
    The Astrophysical Journal 1004 (2026).
date_created: 2026-06-14T22:01:42Z
date_published: 2026-06-10T00:00:00Z
date_updated: 2026-06-19T09:58:52Z
day: '10'
ddc:
- '520'
department:
- _id: YlGo
doi: 10.3847/1538-4357/ae66fd
external_id:
  arxiv:
  - '2604.10440'
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has_accepted_license: '1'
intvolume: '      1004'
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language:
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month: '06'
oa: 1
oa_version: Published Version
publication: The Astrophysical Journal
publication_identifier:
  eissn:
  - 1538-4357
  issn:
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publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
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title: 'A path to constraints on common envelope ejection in massive binaries: Full
  evolutionary reconstruction of three Black Hole X-ray binaries'
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