--- DOAJ_listed: '1' OA_place: publisher OA_type: diamond PlanS_conform: '1' _id: '23047' abstract: - lang: eng text: "Aims. We investigate signatures of pressure extrema on global oscillations in discs.\r\n\r\nMethods. We used the framework of wave topology to establish a generalised local dispersion relation that includes pressure gradients. We highlight the influence of a previously unrecognised epicyclic–acoustic frequency, and we derive an analytical criterion for the existence of a branch of modes transiting between the inertial and the pressure bands, known as topological modes.\r\n\r\nResults. We find that pressure extrema consist of wave guides in which such topological modes propagate. The fundamental mode trapped at a pressure bump can propagate at any frequency, allowing it to resonate with any temporal forcing. Conversely, the fundamental mode associated with a pressure dip propagates at any vertical phase velocity. These specific features make them attractive candidates for future discoseismology." acknowledgement: "AL was funded by Contrat Doctoral Spécifique Normaliens during this work. GL, EL and NP acknowledge funding from\r\nERC CoG project PODCAST No 864965. AL acknowledges funding\r\nfrom ERC StG project Calcifer No 101165631. We used Mathematica\r\n(Wolfram Research Inc, 2024).\r\n" article_number: A355 article_processing_charge: No article_type: original arxiv: 1 author: - first_name: Armand full_name: Leclerc, Armand id: 2a1fb1fc-f373-11ef-901a-87cee43a1217 last_name: Leclerc - first_name: Guillaume full_name: Laibe, Guillaume last_name: Laibe - first_name: Elliot full_name: Lynch, Elliot last_name: Lynch - first_name: Nicolas full_name: Perez, Nicolas last_name: Perez citation: ama: Leclerc A, Laibe G, Lynch E, Perez N. Radial modes of pressure bumps and dips in astrophysical discs. Astronomy & Astrophysics. 2026;708. doi:10.1051/0004-6361/202558428 apa: Leclerc, A., Laibe, G., Lynch, E., & Perez, N. (2026). Radial modes of pressure bumps and dips in astrophysical discs. Astronomy & Astrophysics. EDP Sciences. https://doi.org/10.1051/0004-6361/202558428 chicago: Leclerc, Armand, Guillaume Laibe, Elliot Lynch, and Nicolas Perez. “Radial Modes of Pressure Bumps and Dips in Astrophysical Discs.” Astronomy & Astrophysics. EDP Sciences, 2026. https://doi.org/10.1051/0004-6361/202558428. ieee: A. Leclerc, G. Laibe, E. Lynch, and N. Perez, “Radial modes of pressure bumps and dips in astrophysical discs,” Astronomy & Astrophysics, vol. 708. EDP Sciences, 2026. ista: Leclerc A, Laibe G, Lynch E, Perez N. 2026. Radial modes of pressure bumps and dips in astrophysical discs. Astronomy & Astrophysics. 708, A355. mla: Leclerc, Armand, et al. “Radial Modes of Pressure Bumps and Dips in Astrophysical Discs.” Astronomy & Astrophysics, vol. 708, A355, EDP Sciences, 2026, doi:10.1051/0004-6361/202558428. short: A. Leclerc, G. Laibe, E. Lynch, N. Perez, Astronomy & Astrophysics 708 (2026). corr_author: '1' das_tickbox: '1' dataavailabilitystatement: "The scripts written and used for numerical calculations\r\nare accessible at https://github.com/ArmandLeclerc/\r\nradialStratifDisc." date_created: 2026-10-04T22:01:54Z date_published: 2026-04-01T00:00:00Z date_updated: 2026-10-20T08:14:41Z day: '01' ddc: - '520' department: - _id: LiBu doi: 10.1051/0004-6361/202558428 external_id: arxiv: - '2512.05737' file: - access_level: open_access checksum: 868c1be53a4f3e0cf2852a723fcacd08 content_type: application/pdf creator: dernst date_created: 2026-10-07T12:13:55Z date_updated: 2026-10-07T12:13:55Z file_id: '23075' file_name: 2026_AstronomyAstrophysics_Leclerc.pdf file_size: 10533299 relation: main_file success: 1 file_date_updated: 2026-10-07T12:13:55Z fulldoi: https://doi.org/10.1051/0004-6361/202558428 has_accepted_license: '1' intvolume: ' 708' keyword: - accretion - accretion disks - hydrodynamics - instabilities - waves - protoplanetary disks language: - iso: eng license: https://creativecommons.org/licenses/by/4.0/ month: '04' oa: 1 oa_version: Published Version project: - _id: 914d8549-16d5-11f0-9cad-bbe6324c93a9 grant_number: '101165631' name: 'Unveiling the mysteries of stellar dynamics: a pioneering journey in magnetoasteroseismology' publication: Astronomy & Astrophysics publication_identifier: eissn: - 1432-0746 issn: - 0004-6361 publication_status: published publisher: EDP Sciences quality_controlled: '1' researchdata_availability: no scopus_import: '1' status: public supplementarymaterial: yes title: Radial modes of pressure bumps and dips in astrophysical discs tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 708 year: '2026' ... --- OA_embargo: '12' OA_place: publisher _id: '22744' acknowledged_ssus: - _id: Bio - _id: EM-Fac - _id: ScienComp - _id: LifeSc acknowledgement: "This work was supported by the ERC StG grant ActinID (PRA01221F1049A) awarded to Florian\r\nSchur, the ERC-SyG grant Pushing from within (P01071793) awarded to Michael Sixt, and by ISTA.\r\nI would like to thank the Scientific Service Units at ISTA for their essential support throughout\r\nthis work. In particular, I am grateful to the Electron Microscopy Facility, Imaging and Optics\r\nFacility, Zebrafish Facility, Scientific Computing Facility, and Lab Support Facility for their services,\r\nand technical support, all of which were important for the successful completion of this project." alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Manjunath full_name: Javoor, Manjunath id: 305ab18b-dc7d-11ea-9b2f-b58195228ea2 last_name: Javoor orcid: 0000-0003-2311-2112 citation: ama: Javoor M. Large-scale imaging of cellular actin networks at single filament resolution using montage cryo-electron tomography. 2026. doi:10.15479/AT-ISTA-22744 apa: Javoor, M. (2026). Large-scale imaging of cellular actin networks at single filament resolution using montage cryo-electron tomography. Institute of Science and Technology Austria . https://doi.org/10.15479/AT-ISTA-22744 chicago: Javoor, Manjunath. “Large-Scale Imaging of Cellular Actin Networks at Single Filament Resolution Using Montage Cryo-Electron Tomography.” Institute of Science and Technology Austria , 2026. https://doi.org/10.15479/AT-ISTA-22744. ieee: M. Javoor, “Large-scale imaging of cellular actin networks at single filament resolution using montage cryo-electron tomography,” Institute of Science and Technology Austria , 2026. ista: Javoor M. 2026. Large-scale imaging of cellular actin networks at single filament resolution using montage cryo-electron tomography. Institute of Science and Technology Austria . mla: Javoor, Manjunath. Large-Scale Imaging of Cellular Actin Networks at Single Filament Resolution Using Montage Cryo-Electron Tomography. Institute of Science and Technology Austria , 2026, doi:10.15479/AT-ISTA-22744. short: M. Javoor, Large-Scale Imaging of Cellular Actin Networks at Single Filament Resolution Using Montage Cryo-Electron Tomography, Institute of Science and Technology Austria , 2026. corr_author: '1' date_created: 2026-08-21T09:11:04Z date_published: 2026-08-21T00:00:00Z date_updated: 2026-10-20T08:55:33Z day: '21' ddc: - '570' degree_awarded: PhD department: - _id: GradSch - _id: FlSc - _id: MiSi doi: 10.15479/AT-ISTA-22744 doi_confirm: '1' file: - access_level: closed checksum: f9c2847df9f1ac5a3d60c06b3b81a450 content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document creator: mjavoor date_created: 2026-08-26T12:02:47Z date_updated: 2026-08-27T12:48:42Z file_id: '22767' file_name: 2026_Javoor_Manjunath_Thesis.docx file_size: 27430796 relation: source_file - access_level: closed checksum: 8e9b4c0fcafbccf5c3796eacc9134a08 content_type: application/pdf creator: mjavoor date_created: 2026-08-26T12:02:46Z date_updated: 2026-08-26T12:02:46Z embargo: 2027-08-21 embargo_to: open_access file_id: '22768' file_name: 2026_Javoor_Manjunath_Thesis.pdf file_size: 19489230 relation: main_file file_date_updated: 2026-08-27T12:48:42Z fulldoi: https://doi.org/10.15479/AT-ISTA-22744 has_accepted_license: '1' keyword: - Actin cytoskeleton - Cell migration - cryo-electron tomography language: - iso: eng license: https://creativecommons.org/licenses/by-nc-nd/4.0/ month: '08' oa_version: None page: '121' project: - _id: bd980d18-d553-11ed-ba76-ceaa645c97eb grant_number: '101076260' name: A molecular atlas of Actin filament IDentities in the cell motility machinery - _id: bd91e723-d553-11ed-ba76-fe7eeb2185fd grant_number: '101071793' name: 'Pushing from within: Control of cell shape, integrity and motility by cytoskeletal pushing forces' publication_identifier: isbn: - '978-3-99078-090-9 ' issn: - 2663-337X publication_status: published publisher: 'Institute of Science and Technology Austria ' related_material: record: - id: '12334' relation: part_of_dissertation status: public - id: '21762' relation: part_of_dissertation status: public - id: '12421' relation: part_of_dissertation status: public - id: '19795' relation: part_of_dissertation status: public status: public supervisor: - first_name: Florian KM full_name: Schur, Florian KM id: 48AD8942-F248-11E8-B48F-1D18A9856A87 last_name: Schur orcid: 0000-0003-4790-8078 - first_name: Michael K full_name: Sixt, Michael K id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87 last_name: Sixt orcid: 0000-0002-6620-9179 title: Large-scale imaging of cellular actin networks at single filament resolution using montage cryo-electron tomography tmp: image: /images/cc_by_nc_nd.png legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) short: CC BY-NC-ND (4.0) type: dissertation user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9 year: '2026' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: gold _id: '21754' abstract: - lang: eng text: The origin(s) of life (OoL), which has puzzled scientists for centuries, remains a major scientific challenge in the 21st century. Research on OoL spans many disciplines, including chemistry, physics, biology, planetary sciences, computer science, and mathematics. The sheer number of different scientific perspectives relevant to the problem has resulted in the coexistence of diverse tools, techniques, data, and software in OoL studies. This has made communication between the disciplines relevant to the OoL extremely difficult because the interpretation of data, analyses, or standards of evidence varies dramatically. Here, we hope to bridge this wide field of study by providing common ground via the consolidation of techniques rather than positing a unifying view on how life emerges. In part 1 of this review, we cover common experimental techniques that have been used significantly in OoL studies in recent years, while in part 2, we review theoretical, computational, and integrative methods. Here, we discuss the use of spectroscopy, spectrometry, chromatography, microscopy, and sequencing methods for characterizing diverse materials. We further discuss the role of data repositories in facilitating the analysis and dissemination of experimental data. This review provides a baseline expectation and understanding of the analytical aspects of origins’ research. Ultimately, we aim to provide an educational tool that can facilitate more post-disciplinary collaborations in OoL research by helping scientists understand what they can do about the problem of life’s origins, rather than telling them how to think about it. acknowledgement: This work is a collaborative effort of the titled authors as part of the Origin of Life Early Career Network (OoLEN). We chose to add OoLEN as the first author to give a better representation of this team effort, rather than listing any single author as the first author. We hope such a thing can be adopted by others. We indicate that authors 2–9 (S.A., C.B., C. Blanco, D.B., A.C.-R., C.M., O.M., Z.P., and A.V.D.) have made a more distinct contribution. All authors are listed alphabetically by their last names. We would like to acknowledge all current and past members of OoLEN for their contributions to our community. In particular, we would like to acknowledge Evrim Fer, who helped with molecular phylogenetics. We would like to thank the anonymous referees for reviewing Parts 1 and 2 of this manuscript; this work was significantly improved through their feedback. S.A. acknowledges support from NASA through the postdoctoral Program at GSFC. C. Bautista acknowledges support from “la Caixa” Foundation (ID 100010434) under agreement (LCF/BQ/AA16/11580051) and by the Fonds de recherche du Québec Nature et technologies (FRQNT) (#274987). C. Blanco acknowledges support from NASA under award 80NSSC21K0595. D.B. acknowledges support from Centre national d'études spatiales (CNES) and postdoctoral support from LGPM-CentralSupélec and NASA under award 80NSSC23K1477. E. Camprubi acknowledges support from UT System for a STARs award. A.C.-R. acknowledges funding from the Natural Sciences and Engineering Research Council of Canada (grant number RGPIN/05278–2018), the Fonds de recherche Nature et Technologies of Québec (grant number 314488), and the Fondation J. Armand Bombardier Excellence Scholarship. A.C.-R.’s research was supported by an appointment to the NASA Postdoctoral Program from the NASA Astrobiology Program administered by Oak Ridge Associated Universities under contract with NASA. S.F.J. acknowledges support from “la Caixa” Foundation (ID 100010434) and from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska Curie grant agreement no. 847648 (the fellowship code is LCF/BQ/PI21/11830015). T.Z.J. acknowledges support from Japan Society for the Promotion of Science (JSPS) grants-in-aid 18K14354 and 21K14746, a Tokyo Institute of Technology Yoshinori Ohsumi Fund for Fundamental Research, the Mizuho Foundation for the Promotion of Sciences, and by the Temporary Assistant Program by the DE&I Section of Science Tokyo. A.K. acknowledges support from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie Grant agreement no. 101068029. C.M. acknowledges support from NASA through the postdoctoral Fellowship Program. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of NASA. O.M. acknowledges support from The John Templeton Foundation (#62828) and the Foundation for Science and Technology (2023.05971.CEECIND). B.K.D.P. acknowledges support from the NSERC Banting Postdoctoral Fellowship. K.P. acknowledges financial support from the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy EXC 2181/1 - 390900948 (the Heidelberg STRUCTURES Excellence Cluster) and is a fellow of the International Max Planck Research School for Astronomy and Cosmic Physics at the University of Heidelberg (IMPRS-HD). article_number: '103212' article_processing_charge: Yes article_type: original author: - first_name: Silke full_name: Asche, Silke last_name: Asche - first_name: Carla full_name: Bautista, Carla last_name: Bautista - first_name: Celia full_name: Blanco, Celia last_name: Blanco - first_name: David full_name: Boulesteix, David last_name: Boulesteix - first_name: Alexandre full_name: Champagne-Ruel, Alexandre last_name: Champagne-Ruel - first_name: Cole full_name: Mathis, Cole last_name: Mathis - first_name: Omer full_name: Markovitch, Omer last_name: Markovitch - first_name: Zhen full_name: Peng, Zhen last_name: Peng - first_name: Avinash Vicholous full_name: Dass, Avinash Vicholous last_name: Dass - first_name: Alyssa full_name: Adams, Alyssa last_name: Adams - first_name: Eloi full_name: Camprubi, Eloi last_name: Camprubi - first_name: Enrico Sandro full_name: Colizzi, Enrico Sandro last_name: Colizzi - first_name: Stephanie full_name: Colón-Santos, Stephanie last_name: Colón-Santos - first_name: Hannah full_name: Dromiack, Hannah last_name: Dromiack - first_name: Valentina full_name: Erastova, Valentina last_name: Erastova - first_name: Amanda full_name: Garcia, Amanda last_name: Garcia - first_name: Ghjuvan full_name: Grimaud, Ghjuvan last_name: Grimaud - first_name: Aaron full_name: Halpern, Aaron last_name: Halpern - first_name: Stuart A. full_name: Harrison, Stuart A. last_name: Harrison - first_name: Seán F. full_name: Jordan, Seán F. last_name: Jordan - first_name: Tony Z. full_name: Jia, Tony Z. last_name: Jia - first_name: Amit full_name: Kahana, Amit last_name: Kahana - first_name: Artemy full_name: Kolchinsky, Artemy last_name: Kolchinsky - first_name: Odin full_name: Moron-Garcia, Odin last_name: Moron-Garcia - first_name: Ryo full_name: Mizuuchi, Ryo last_name: Mizuuchi - first_name: Jingbo full_name: Nan, Jingbo last_name: 'Nan' - first_name: Yuliia full_name: Orlova, Yuliia last_name: Orlova - first_name: Ben K.D. full_name: Pearce, Ben K.D. last_name: Pearce - first_name: Klaus full_name: Paschek, Klaus last_name: Paschek - first_name: Martina full_name: Preiner, Martina last_name: Preiner - first_name: Silvana full_name: Pinna, Silvana last_name: Pinna - first_name: Eduardo full_name: Rodríguez-Román, Eduardo last_name: Rodríguez-Román - first_name: Loraine full_name: Schwander, Loraine last_name: Schwander - first_name: Siddhant full_name: Sharma, Siddhant id: 36996868-4916-11f1-8c9d-c0c901467b61 last_name: Sharma - first_name: Harrison B. full_name: Smith, Harrison B. last_name: Smith - first_name: Andrey full_name: Vieira, Andrey last_name: Vieira - first_name: Joana C. full_name: Xavier, Joana C. last_name: Xavier citation: ama: 'Asche S, Bautista C, Blanco C, et al. What it takes to solve the origin of life: An integrated review. Part 1–Experimental methods and data repositories. Cell Reports Physical Science. 2026;7(4). doi:10.1016/j.xcrp.2026.103212' apa: 'Asche, S., Bautista, C., Blanco, C., Boulesteix, D., Champagne-Ruel, A., Mathis, C., … Xavier, J. C. (2026). What it takes to solve the origin of life: An integrated review. Part 1–Experimental methods and data repositories. Cell Reports Physical Science. Cell Press. https://doi.org/10.1016/j.xcrp.2026.103212' chicago: 'Asche, Silke, Carla Bautista, Celia Blanco, David Boulesteix, Alexandre Champagne-Ruel, Cole Mathis, Omer Markovitch, et al. “What It Takes to Solve the Origin of Life: An Integrated Review. Part 1–Experimental Methods and Data Repositories.” Cell Reports Physical Science. Cell Press, 2026. https://doi.org/10.1016/j.xcrp.2026.103212.' ieee: 'S. Asche et al., “What it takes to solve the origin of life: An integrated review. Part 1–Experimental methods and data repositories,” Cell Reports Physical Science, vol. 7, no. 4. Cell Press, 2026.' ista: 'Asche S, Bautista C, Blanco C, Boulesteix D, Champagne-Ruel A, Mathis C, Markovitch O, Peng Z, Dass AV, Adams A, Camprubi E, Colizzi ES, Colón-Santos S, Dromiack H, Erastova V, Garcia A, Grimaud G, Halpern A, Harrison SA, Jordan SF, Jia TZ, Kahana A, Kolchinsky A, Moron-Garcia O, Mizuuchi R, Nan J, Orlova Y, Pearce BKD, Paschek K, Preiner M, Pinna S, Rodríguez-Román E, Schwander L, Sharma S, Smith HB, Vieira A, Xavier JC. 2026. What it takes to solve the origin of life: An integrated review. Part 1–Experimental methods and data repositories. Cell Reports Physical Science. 7(4), 103212.' mla: 'Asche, Silke, et al. “What It Takes to Solve the Origin of Life: An Integrated Review. Part 1–Experimental Methods and Data Repositories.” Cell Reports Physical Science, vol. 7, no. 4, 103212, Cell Press, 2026, doi:10.1016/j.xcrp.2026.103212.' short: S. Asche, C. Bautista, C. Blanco, D. Boulesteix, A. Champagne-Ruel, C. Mathis, O. Markovitch, Z. Peng, A.V. Dass, A. Adams, E. Camprubi, E.S. Colizzi, S. Colón-Santos, H. Dromiack, V. Erastova, A. Garcia, G. Grimaud, A. Halpern, S.A. Harrison, S.F. Jordan, T.Z. Jia, A. Kahana, A. Kolchinsky, O. Moron-Garcia, R. Mizuuchi, J. Nan, Y. Orlova, B.K.D. Pearce, K. Paschek, M. Preiner, S. Pinna, E. Rodríguez-Román, L. Schwander, S. Sharma, H.B. Smith, A. Vieira, J.C. Xavier, Cell Reports Physical Science 7 (2026). date_created: 2026-04-19T22:07:52Z date_published: 2026-04-15T00:00:00Z date_updated: 2026-10-20T08:59:19Z day: '15' ddc: - '570' doi: 10.1016/j.xcrp.2026.103212 file: - access_level: open_access checksum: e580d22c2874c0afcbde2d167db7201b content_type: application/pdf creator: dernst date_created: 2026-05-07T05:48:23Z date_updated: 2026-05-07T05:48:23Z file_id: '21831' file_name: 2026_CellREports_OoLEN1.pdf file_size: 3535247 relation: main_file success: 1 file_date_updated: 2026-05-07T05:48:23Z fulldoi: https://doi.org/10.1016/j.xcrp.2026.103212 has_accepted_license: '1' intvolume: ' 7' issue: '4' language: - iso: eng month: '04' oa: 1 oa_version: Published Version publication: Cell Reports Physical Science publication_identifier: eissn: - 2666-3864 publication_status: published publisher: Cell Press quality_controlled: '1' scopus_import: '1' status: public title: 'What it takes to solve the origin of life: An integrated review. Part 1–Experimental methods and data repositories' tmp: image: /images/cc_by_nc_nd.png legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) short: CC BY-NC-ND (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 7 year: '2026' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: gold _id: '21753' abstract: - lang: eng text: The origin(s) of life (OoL), which has puzzled scientists for centuries, remains a major scientific challenge in the 21st century. Understanding the processes relevant to the OoL demands theoretical frameworks that can connect processes across scales, from microscopic dynamics to emergent levels of organization. While experimental studies generate a wealth of data, theoretical and computational approaches provide the structure necessary to interpret and generalize these findings. In Part 1, we examined the most widely used experimental techniques in the field. Here, we focus on the mathematical, physical, and computational techniques used to model phenomena relevant to life’s origin(s). We discuss methods ranging from quantum chemistry and molecular dynamics to chemical reaction networks, autocatalysis, and evolutionary modeling, as well as information-theoretic and phylogenetic approaches that link chemical and biological organization. We further highlight emerging trends such as synthetic biology, omics-based methods, and laboratory automation as novel points of contact for theory-experiment integration. Ultimately, we aim to provide an educational tool that can facilitate more post-disciplinary collaborations in OoL research by helping scientists understand what they can do about the problem of life’s origins, rather than telling them how to think about it. acknowledgement: This work is a collaborative effort of the titled authors as part of the Origin of Life Early Career Network (OoLEN). We chose to add OoLEN as the first author to give a better representation of this team effort, rather than listing any single author as the first author. We hope such a thing can be adopted by others. We indicate that authors 2–9 (S.A., C.B., C. Blanco, D.B., A.C.-R., C.M., O.M., Z.P., and A.V.D.) have made a more distinct contribution. All authors are listed alphabetically by their last names. We would like to acknowledge all current and past members of OoLEN for their contributions to our community. In particular, we would like to acknowledge Evrim Fer, who helped with molecular phylogenetics. We would like to thank the anonymous referees for reviewing Parts 1 and 2 of this manuscript; this work was significantly improved through their feedback. S.A. acknowledges support from NASA through the postdoctoral Program at GSFC. C. Bautista acknowledges support from “la Caixa” Foundation (ID 100010434) under agreement (LCF/BQ/AA16/11580051) and by the Fonds de recherche du Québec Nature et technologies (FRQNT) (#274987). C. Blanco acknowledges support from NASA under award 80NSSC21K0595. D.B. acknowledges support from Centre national d'études spatiales (CNES) and postdoctoral support from LGPM-CentralSupélec and NASA under award 80NSSC23K1477. E. Camprubi acknowledges support from UT System for a STARs award. A.C.-R. acknowledges funding from the Natural Sciences and Engineering Research Council of Canada (grant number RGPIN/05278–2018), the Fonds de recherche Nature et Technologies of Québec (grant number 314488), and the Fondation J. Armand Bombardier Excellence Scholarship. A.C.-R.’s research was supported by an appointment to the NASA Postdoctoral Program from the NASA Astrobiology Program administered by Oak Ridge Associated Universities under contract with NASA. S.F.J. acknowledges support from “la Caixa” Foundation (ID 100010434) and from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska Curie grant agreement no. 847648 (the fellowship code is LCF/BQ/PI21/11830015). T.Z.J. acknowledges support from Japan Society for the Promotion of Science (JSPS) grants-in-aid 18K14354 and 21K14746, a Tokyo Institute of Technology Yoshinori Ohsumi Fund for Fundamental Research, the Mizuho Foundation for the Promotion of Sciences, and by the Temporary Assistant Program by the DE&I Section of Science Tokyo. A.K. acknowledges support from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie Grant agreement no. 101068029. C.M. acknowledges support from NASA through the postdoctoral Fellowship Program. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of NASA. O.M. acknowledges support from The John Templeton Foundation (#62828) and the Foundation for Science and Technology (2023.05971.CEECIND). B.K.D.P. acknowledges support from the NSERC Banting Postdoctoral Fellowship. K.P. acknowledges financial support from the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy EXC 2181/1 - 390900948 (the Heidelberg STRUCTURES Excellence Cluster) and is a fellow of the International Max Planck Research School for Astronomy and Cosmic Physics at the University of Heidelberg (IMPRS-HD). article_number: '103211' article_processing_charge: Yes article_type: original author: - first_name: Silke full_name: Asche, Silke last_name: Asche - first_name: Carla full_name: Bautista, Carla last_name: Bautista - first_name: Celia full_name: Blanco, Celia last_name: Blanco - first_name: David full_name: Boulesteix, David last_name: Boulesteix - first_name: Alexandre full_name: Champagne-Ruel, Alexandre last_name: Champagne-Ruel - first_name: Cole full_name: Mathis, Cole last_name: Mathis - first_name: Omer full_name: Markovitch, Omer last_name: Markovitch - first_name: Zhen full_name: Peng, Zhen last_name: Peng - first_name: Avinash Vicholous full_name: Dass, Avinash Vicholous last_name: Dass - first_name: Alyssa full_name: Adams, Alyssa last_name: Adams - first_name: Eloi full_name: Camprubi, Eloi last_name: Camprubi - first_name: Enrico Sandro full_name: Colizzi, Enrico Sandro last_name: Colizzi - first_name: Stephanie full_name: Colón-Santos, Stephanie last_name: Colón-Santos - first_name: Hannah full_name: Dromiack, Hannah last_name: Dromiack - first_name: Valentina full_name: Erastova, Valentina last_name: Erastova - first_name: Amanda full_name: Garcia, Amanda last_name: Garcia - first_name: Ghjuvan full_name: Grimaud, Ghjuvan last_name: Grimaud - first_name: Aaron full_name: Halpern, Aaron last_name: Halpern - first_name: Stuart A. full_name: Harrison, Stuart A. last_name: Harrison - first_name: Seán F. full_name: Jordan, Seán F. last_name: Jordan - first_name: Tony Z. full_name: Jia, Tony Z. last_name: Jia - first_name: Amit full_name: Kahana, Amit last_name: Kahana - first_name: Artemy full_name: Kolchinsky, Artemy last_name: Kolchinsky - first_name: Odin full_name: Moron-Garcia, Odin last_name: Moron-Garcia - first_name: Ryo full_name: Mizuuchi, Ryo last_name: Mizuuchi - first_name: Jingbo full_name: Nan, Jingbo last_name: 'Nan' - first_name: Yuliia full_name: Orlova, Yuliia last_name: Orlova - first_name: Ben K.D. full_name: Pearce, Ben K.D. last_name: Pearce - first_name: Klaus full_name: Paschek, Klaus last_name: Paschek - first_name: Martina full_name: Preiner, Martina last_name: Preiner - first_name: Silvana full_name: Pinna, Silvana last_name: Pinna - first_name: Eduardo full_name: Rodríguez-Román, Eduardo last_name: Rodríguez-Román - first_name: Loraine full_name: Schwander, Loraine last_name: Schwander - first_name: Siddhant full_name: Sharma, Siddhant id: 36996868-4916-11f1-8c9d-c0c901467b61 last_name: Sharma - first_name: Harrison B. full_name: Smith, Harrison B. last_name: Smith - first_name: Andrey full_name: Vieira, Andrey last_name: Vieira - first_name: Joana C. full_name: Xavier, Joana C. last_name: Xavier citation: ama: 'Asche S, Bautista C, Blanco C, et al. What it takes to solve the origins of life: An integrated review. Part 2: Theoretical methods and emerging trends. Cell Reports Physical Science. 2026;7(4). doi:10.1016/j.xcrp.2026.103211' apa: 'Asche, S., Bautista, C., Blanco, C., Boulesteix, D., Champagne-Ruel, A., Mathis, C., … Xavier, J. C. (2026). What it takes to solve the origins of life: An integrated review. Part 2: Theoretical methods and emerging trends. Cell Reports Physical Science. Cell Press. https://doi.org/10.1016/j.xcrp.2026.103211' chicago: 'Asche, Silke, Carla Bautista, Celia Blanco, David Boulesteix, Alexandre Champagne-Ruel, Cole Mathis, Omer Markovitch, et al. “What It Takes to Solve the Origins of Life: An Integrated Review. Part 2: Theoretical Methods and Emerging Trends.” Cell Reports Physical Science. Cell Press, 2026. https://doi.org/10.1016/j.xcrp.2026.103211.' ieee: 'S. Asche et al., “What it takes to solve the origins of life: An integrated review. Part 2: Theoretical methods and emerging trends,” Cell Reports Physical Science, vol. 7, no. 4. Cell Press, 2026.' ista: 'Asche S, Bautista C, Blanco C, Boulesteix D, Champagne-Ruel A, Mathis C, Markovitch O, Peng Z, Dass AV, Adams A, Camprubi E, Colizzi ES, Colón-Santos S, Dromiack H, Erastova V, Garcia A, Grimaud G, Halpern A, Harrison SA, Jordan SF, Jia TZ, Kahana A, Kolchinsky A, Moron-Garcia O, Mizuuchi R, Nan J, Orlova Y, Pearce BKD, Paschek K, Preiner M, Pinna S, Rodríguez-Román E, Schwander L, Sharma S, Smith HB, Vieira A, Xavier JC. 2026. What it takes to solve the origins of life: An integrated review. Part 2: Theoretical methods and emerging trends. Cell Reports Physical Science. 7(4), 103211.' mla: 'Asche, Silke, et al. “What It Takes to Solve the Origins of Life: An Integrated Review. Part 2: Theoretical Methods and Emerging Trends.” Cell Reports Physical Science, vol. 7, no. 4, 103211, Cell Press, 2026, doi:10.1016/j.xcrp.2026.103211.' short: S. Asche, C. Bautista, C. Blanco, D. Boulesteix, A. Champagne-Ruel, C. Mathis, O. Markovitch, Z. Peng, A.V. Dass, A. Adams, E. Camprubi, E.S. Colizzi, S. Colón-Santos, H. Dromiack, V. Erastova, A. Garcia, G. Grimaud, A. Halpern, S.A. Harrison, S.F. Jordan, T.Z. Jia, A. Kahana, A. Kolchinsky, O. Moron-Garcia, R. Mizuuchi, J. Nan, Y. Orlova, B.K.D. Pearce, K. Paschek, M. Preiner, S. Pinna, E. Rodríguez-Román, L. Schwander, S. Sharma, H.B. Smith, A. Vieira, J.C. Xavier, Cell Reports Physical Science 7 (2026). date_created: 2026-04-19T22:07:50Z date_published: 2026-04-15T00:00:00Z date_updated: 2026-10-20T08:58:31Z day: '15' ddc: - '570' doi: 10.1016/j.xcrp.2026.103211 file: - access_level: open_access checksum: d5abe5b5bd4b9ee58aa6f4917f688ad9 content_type: application/pdf creator: dernst date_created: 2026-05-06T06:48:33Z date_updated: 2026-05-06T06:48:33Z file_id: '21804' file_name: 2026_CellReports_OoLEN.pdf file_size: 5265320 relation: main_file success: 1 file_date_updated: 2026-05-06T06:48:33Z fulldoi: https://doi.org/10.1016/j.xcrp.2026.103211 has_accepted_license: '1' intvolume: ' 7' issue: '4' language: - iso: eng month: '04' oa: 1 oa_version: Published Version publication: Cell Reports Physical Science publication_identifier: eissn: - 2666-3864 publication_status: published publisher: Cell Press quality_controlled: '1' scopus_import: '1' status: public title: 'What it takes to solve the origins of life: An integrated review. Part 2: Theoretical methods and emerging trends' tmp: image: /images/cc_by_nc_nd.png legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) short: CC BY-NC-ND (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 7 year: '2026' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: gold _id: '21744' abstract: - lang: eng text: The paraventricular hypothalamus (PVH) controls behavioral and physiologic processes, including appetite, social behavior, autonomic outflow, and pituitary hormone secretion. However, molecular markers for centrally projecting PVH neuron populations remain largely undefined, and a complete census of PVH cell types has not been established. Therefore, we performed extensive single-cell/nucleus RNA sequencing to catalog PVH neuron subtypes and multiplexed error-robust fluorescence in situ hybridization (MERFISH) to map them spatially. Our spatial transcriptomic atlas resolves 26 Sim1+ and 29 GABAergic neuron populations from the PVH and surrounding areas. Additionally, projection-based profiling identified neurons that project to the parabrachial region (PB) and spinal cord, helping to determine PVH populations that regulate satiety and sympathetic nervous system activity, respectively. Notably, activation of PB-projecting PVH neurons expressing Brs3 reduces food intake, and silencing them causes obesity. Together, this atlas contributes high-resolution PVH spatial and circuit-based gene expression profiles, representing a valuable resource for the field of homeostasis. acknowledgement: "We would like to thank Drs. Mark Andermann, Joel Geerling, and Clifford\r\nSaper, as well as the Lowell, Tsai, and Resch laboratories for helpful discussions;\r\nAlysia Berns, Jia Yu, and Yanfang Li for technical support; the BNORC\r\nFunctional Genomics and Bioinformatics Core (P30DK046200) and the Iowa\r\nInstitute for Human Genetics Genomics Division (IIHG, RRID: SCR_023422)\r\nfor helpful discussions and technical assistance with sc/snRNA-seq; Zachary\r\nNiziolek and the Bauer Core Facility at Harvard University, the BIDMC Flow Cytometry\r\nCore, and Heath Vignes, Michael Shey, and Thomas Kaufman of the\r\nFlow Cytometry Facility at the University of Iowa Carver College of Medicine\r\nfor helpful discussions and technical support; the ICCB-Longwood Screening\r\nFacility of Harvard Medical School for assistance with the snRNA-seq\r\nexperiments; Dr. Sayak Mitter and Vizgen support for technical assistance\r\nwith the MERSCOPE platform; and Mara Jendro and Li-Chun (Queena) Lin\r\nfor their assistance with MERSCOPE experiments within the Iowa\r\nNeuroBank Core in the Iowa Neuroscience Institute at the University of Iowa\r\nCarver College of Medicine. This research was funded by the following NIH\r\ngrants to L.T.T.: R01DK128406; to B.B.L.: R01DK075632, R01DK134427,\r\nand R01DK096010; to J.M.R.: R00HL144923 and R01NS141072; and to M.C.M.: F31HL170784; T.C.B. and M.C.M. were supported by a pharmacological\r\nsciences predoctoral training grant T32GM144636. Additional funding\r\nto J.M.R. came from the American Heart Association (AHA 935362), a University\r\nof Iowa Fraternal Order of Eagles Diabetes Research Center Pilot and\r\nFeasibility Catalyst Grant, and an Iowa Neuroscience Institute Early Stage\r\nInvestigator award from the Carver Trust. Y.L. was supported by a predoctoral\r\nfellowship from the American Heart Association (AHA 25PRE1372983). A.M.D.\r\nwas supported by a postdoctoral fellowship from the Charles A. King Trust." article_number: '116904' article_processing_charge: Yes article_type: original author: - first_name: Yuxi full_name: Li, Yuxi last_name: Li - first_name: Trevor C. full_name: Butler, Trevor C. last_name: Butler - first_name: Stefano full_name: Nardone, Stefano last_name: Nardone - first_name: Christopher L. full_name: Jacobs, Christopher L. last_name: Jacobs - first_name: Amelia May Barnett full_name: Douglass, Amelia May Barnett id: de5f6fda-80fb-11ef-996f-a8c4ecd8e289 last_name: Douglass orcid: 0000-0001-5398-6473 - first_name: Joseph C. full_name: Madara, Joseph C. last_name: Madara - first_name: Miriam C. full_name: McDonough, Miriam C. last_name: McDonough - first_name: Jenkang full_name: Tao, Jenkang last_name: Tao - first_name: Elijah D. full_name: Lowenstein, Elijah D. last_name: Lowenstein - first_name: Luhong full_name: Wang, Luhong last_name: Wang - first_name: Deepti full_name: Pant, Deepti last_name: Pant - first_name: Samuel J. full_name: Walker, Samuel J. last_name: Walker - first_name: Annette full_name: Wang, Annette last_name: Wang - first_name: Harini full_name: Srinivasan, Harini last_name: Srinivasan - first_name: Zongfang full_name: Yang, Zongfang last_name: Yang - first_name: John N. full_name: Campbell, John N. last_name: Campbell - first_name: Linus T. full_name: Tsai, Linus T. last_name: Tsai - first_name: Bradford B. full_name: Lowell, Bradford B. last_name: Lowell - first_name: Jon M. full_name: Resch, Jon M. last_name: Resch citation: ama: Li Y, Butler TC, Nardone S, et al. A spatial and projection-based transcriptomic atlas of paraventricular hypothalamic cell types. Cell Reports. 2026;45(2). doi:10.1016/j.celrep.2025.116904 apa: Li, Y., Butler, T. C., Nardone, S., Jacobs, C. L., Douglass, A. M., Madara, J. C., … Resch, J. M. (2026). A spatial and projection-based transcriptomic atlas of paraventricular hypothalamic cell types. Cell Reports. Cell Press. https://doi.org/10.1016/j.celrep.2025.116904 chicago: Li, Yuxi, Trevor C. Butler, Stefano Nardone, Christopher L. Jacobs, Amelia M. Douglass, Joseph C. Madara, Miriam C. McDonough, et al. “A Spatial and Projection-Based Transcriptomic Atlas of Paraventricular Hypothalamic Cell Types.” Cell Reports. Cell Press, 2026. https://doi.org/10.1016/j.celrep.2025.116904. ieee: Y. Li et al., “A spatial and projection-based transcriptomic atlas of paraventricular hypothalamic cell types,” Cell Reports, vol. 45, no. 2. Cell Press, 2026. ista: Li Y, Butler TC, Nardone S, Jacobs CL, Douglass AM, Madara JC, McDonough MC, Tao J, Lowenstein ED, Wang L, Pant D, Walker SJ, Wang A, Srinivasan H, Yang Z, Campbell JN, Tsai LT, Lowell BB, Resch JM. 2026. A spatial and projection-based transcriptomic atlas of paraventricular hypothalamic cell types. Cell Reports. 45(2), 116904. mla: Li, Yuxi, et al. “A Spatial and Projection-Based Transcriptomic Atlas of Paraventricular Hypothalamic Cell Types.” Cell Reports, vol. 45, no. 2, 116904, Cell Press, 2026, doi:10.1016/j.celrep.2025.116904. short: Y. Li, T.C. Butler, S. Nardone, C.L. Jacobs, A.M. Douglass, J.C. Madara, M.C. McDonough, J. Tao, E.D. Lowenstein, L. Wang, D. Pant, S.J. Walker, A. Wang, H. Srinivasan, Z. Yang, J.N. Campbell, L.T. Tsai, B.B. Lowell, J.M. Resch, Cell Reports 45 (2026). date_created: 2026-04-16T13:51:29Z date_published: 2026-02-24T00:00:00Z date_updated: 2026-10-20T08:58:10Z day: '24' ddc: - '570' department: - _id: AmDo doi: 10.1016/j.celrep.2025.116904 external_id: pmid: - '41581146' file: - access_level: open_access checksum: 82098dd9d0ca609119f9f2c6beb4fc1e content_type: application/pdf creator: dernst date_created: 2026-05-04T11:58:51Z date_updated: 2026-05-04T11:58:51Z file_id: '21793' file_name: 2026_CellReports_Li.pdf file_size: 38532865 relation: main_file success: 1 file_date_updated: 2026-05-04T11:58:51Z fulldoi: https://doi.org/10.1016/j.celrep.2025.116904 has_accepted_license: '1' intvolume: ' 45' issue: '2' language: - iso: eng month: '02' oa: 1 oa_version: Published Version pmid: 1 publication: Cell Reports publication_identifier: eissn: - 2211-1247 issn: - 2639-1856 publication_status: published publisher: Cell Press quality_controlled: '1' scopus_import: '1' status: public title: A spatial and projection-based transcriptomic atlas of paraventricular hypothalamic cell types tmp: image: /images/cc_by_nc_nd.png legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) short: CC BY-NC-ND (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 45 year: '2026' ... --- OA_place: publisher OA_type: hybrid PlanS_conform: '1' _id: '21490' abstract: - lang: eng text: Auxin canalization is a self-organizing process that governs the flexible formation of vasculature by reinforcing the formation of auxin transport channels. A key prerequisite is the feedback between auxin signaling and directional auxin transport, mediated by PIN transporters. Despite the developmental importance of canalization, the molecular components linking auxin perception to the regulation of PIN auxin transporters remain poorly understood. Here, we identify TOW, a novel and essential component of auxin canalization that links intracellular auxin signaling with cell surface auxin perception. TOW is regulated downstream of TIR1/AFB-Aux/IAA-WRKY23 transcriptional auxin signaling. tow mutants exhibit defects in regeneration and de novo vasculature formation, along with impaired formation of polarized, PIN-expressing auxin channels. At the subcellular level, these mutants display disrupted auxin-induced PIN polarization and altered PIN endocytic trafficking dynamics. TOW localizes predominantly to the plasma membrane, where it interacts with receptor-like kinases involved in auxin canalization, including the TMK1 auxin co-receptor and the CAMEL-CANAR complex. TOW promotes PIN interaction with these kinases and stabilizes PINs at the cell surface. Together, our findings identify TOW as a molecular link between intracellular and cell surface auxin signaling mechanisms that converge on PIN trafficking and polarity, providing new insights into how auxin signaling regulates directional auxin transport for the self-organizing formation of vasculature during flexible plant development. acknowledged_ssus: - _id: MassSpec - _id: Bio - _id: LifeSc acknowledgement: We thank Dr. Z. Ge (ISTA) for providing vectors for the CRISPR-Cas9 system, Dr. Armel Nicolas and Dr. Bella Bruszel for phosphoproteomic analysis, Prof. Michael Wrzaczek (Czech Academy of Sciences, Czechia) for valuable suggestions, and Prof. Maciek Adamowski (University of Gdańsk) for technical assistance. We also acknowledge the support of the Mass Spectrometry and Proteomics Facility, the Imaging & Optics Facility, and the Lab Support Facility at the Institute of Science and Technology Austria. This research was supported by the Scientific Service Units (SSU) of ISTA, utilizing resources provided by the Imaging & Optics Facility (IOF) and the Lab Support Facility (LSF). The work conducted by the Friml group was funded by the European Research Council (ERC) under grant agreement no. 101142681 (CYNIPS) and by the Austrian Science Fund (FWF) under project ESP271. We acknowledge the core facility CELLIM supported by MEYS CR (LM2023050 Czech-BioImaging) and the Plant Sciences Core Facility of CEITEC Masaryk University. E.M. received support from the National Science Centre (NCN), Poland, through the OPUS call within the Weave programme (grant no. 2021/43/I/NZ1/01835). T.N. received support from TowArds Next GENeration Crops, reg. no. CZ.02.01.01/00/22_008/0004581 of the ERDF Programme Johannes Amos Comenius. article_processing_charge: Yes (via OA deal) article_type: original author: - first_name: Mingyue full_name: Li, Mingyue id: 01f96916-0235-11eb-9379-a323192643b7 last_name: Li - first_name: Nikola full_name: Rydza, Nikola last_name: Rydza - first_name: Ewa full_name: Mazur, Ewa last_name: Mazur - first_name: Gergely full_name: Molnar, Gergely id: 34F1AF46-F248-11E8-B48F-1D18A9856A87 last_name: Molnar - first_name: Tomasz full_name: Nodzyński, Tomasz last_name: Nodzyński - first_name: Jiří full_name: Friml, Jiří id: 4159519E-F248-11E8-B48F-1D18A9856A87 last_name: Friml orcid: 0000-0002-8302-7596 citation: ama: Li M, Rydza N, Mazur E, Molnar G, Nodzyński T, Friml J. Receptor-like-kinase-interacting protein TOW stabilizes PIN transporters for auxin canalization. Current Biology. 2026;36(6):1468-1480.e6. doi:10.1016/j.cub.2026.02.023 apa: Li, M., Rydza, N., Mazur, E., Molnar, G., Nodzyński, T., & Friml, J. (2026). Receptor-like-kinase-interacting protein TOW stabilizes PIN transporters for auxin canalization. Current Biology. Cell Press. https://doi.org/10.1016/j.cub.2026.02.023 chicago: Li, Mingyue, Nikola Rydza, Ewa Mazur, Gergely Molnar, Tomasz Nodzyński, and Jiří Friml. “Receptor-like-Kinase-Interacting Protein TOW Stabilizes PIN Transporters for Auxin Canalization.” Current Biology. Cell Press, 2026. https://doi.org/10.1016/j.cub.2026.02.023. ieee: M. Li, N. Rydza, E. Mazur, G. Molnar, T. Nodzyński, and J. Friml, “Receptor-like-kinase-interacting protein TOW stabilizes PIN transporters for auxin canalization,” Current Biology, vol. 36, no. 6. Cell Press, p. 1468–1480.e6, 2026. ista: Li M, Rydza N, Mazur E, Molnar G, Nodzyński T, Friml J. 2026. Receptor-like-kinase-interacting protein TOW stabilizes PIN transporters for auxin canalization. Current Biology. 36(6), 1468–1480.e6. mla: Li, Mingyue, et al. “Receptor-like-Kinase-Interacting Protein TOW Stabilizes PIN Transporters for Auxin Canalization.” Current Biology, vol. 36, no. 6, Cell Press, 2026, p. 1468–1480.e6, doi:10.1016/j.cub.2026.02.023. short: M. Li, N. Rydza, E. Mazur, G. Molnar, T. Nodzyński, J. Friml, Current Biology 36 (2026) 1468–1480.e6. corr_author: '1' date_created: 2026-03-23T15:11:16Z date_published: 2026-03-23T00:00:00Z date_updated: 2026-10-20T08:57:40Z day: '23' ddc: - '580' department: - _id: JiFr doi: 10.1016/j.cub.2026.02.023 external_id: pmid: - '41831441' file: - access_level: open_access checksum: fe6c41fdab58a55df5f2a5860c02acdc content_type: application/pdf creator: dernst date_created: 2026-03-24T08:34:37Z date_updated: 2026-03-24T08:34:37Z file_id: '21496' file_name: 2026_CurrentBiology_Li.pdf file_size: 12986894 relation: main_file success: 1 file_date_updated: 2026-03-24T08:34:37Z fulldoi: https://doi.org/10.1016/j.cub.2026.02.023 has_accepted_license: '1' intvolume: ' 36' issue: '6' language: - iso: eng month: '03' oa: 1 oa_version: Published Version page: 1468-1480.e6 pmid: 1 project: - _id: 8f347782-16d5-11f0-9cad-8c19706ee739 grant_number: '101142681' name: Cyclic nucleotides as second messengers in plants - _id: bd906599-d553-11ed-ba76-abf8547645d7 grant_number: E271 name: Identification of a novel regulator in auxin canalization publication: Current Biology publication_identifier: issn: - 0960-9822 publication_status: published publisher: Cell Press quality_controlled: '1' status: public title: Receptor-like-kinase-interacting protein TOW stabilizes PIN transporters for auxin canalization tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 36 year: '2026' ... --- OA_place: publisher OA_type: hybrid PlanS_conform: '1' _id: '21509' abstract: - lang: eng text: Chromatin remodeling complexes mobilize nucleosomes and promote transcription factor (TF) binding. Using ensemble and single-molecule assays combined with cryo-electron microscopy (cryo-EM), we studied the interaction between pioneer TFs OCT4–SOX2 and the human BRG1/BRM-associated factor (BAF) complex on nucleosomes. BAF engages TF-bound substrates in two orientations, placing OCT4–SOX2 at either the remodeler ENTRY or EXIT site. At the ENTRY site, OCT4–SOX2 initially coexists with BAF without structural interference. However, continued DNA translocation is expected to cause collisions with bound TFs, which can trigger remodeling direction reversals or may induce TF dissociation. To accommodate TFs at the EXIT site, BAF undergoes structural rearrangements, and ensemble assays reveal a nucleosome subpopulation translocating away from TF-binding sites. Moreover, single-molecule experiments show that nucleosome-bound BAF frequently changes remodeling direction, and we identify an ADP-bound remodeler conformation as a potential intermediate. Together, these findings reveal key aspects of the conformational dynamics and remodeling outcomes underlying BAF processing of TF-bound nucleosomes. acknowledgement: We thank D. Hess, V. Iesmantavicius, and J. Seebacher (FMI Proteomics and Protein Analysis Facility) for mass spectrometry support; S. Smallwood, K. Shimada, D. Klein, and M. Schütz-Stoffregen for technical assistance; J. Côté and C. Lachance for critical discussions; and members of the Thomä lab for helpful feedback. Support for this work was provided to N.H.T. by the European Research Council under the European Union’s Horizon 2020 research program (NucEM, no. 884331), the Novartis Research Foundation, the Swiss National Science Foundation (SNF 31003A_179541, 310030_214852, and Sinergia CRSII5_186230), and the Swiss Cancer Research (KFS-4980-02-2020 and KFS-5933-08-2023). S.D. was supported by the European Research Council (DONUTS, no. 101092623), the Knut and Alice Wallenberg Foundation (2024.0012), the Cancerfonden (25 4453 Pj), and the Swedish Research Council (VR 03255). A.K.M. was supported by a Human Frontier Science Program Long-Term Fellowship, and L.V. was supported by an EMBO fellowship (ALTF 549-2021). article_processing_charge: Yes (in subscription journal) article_type: original author: - first_name: Joscha full_name: Weiss, Joscha last_name: Weiss - first_name: Luca full_name: Vecchia, Luca last_name: Vecchia - first_name: David full_name: Domjan, David last_name: Domjan - first_name: Simone full_name: Cavadini, Simone last_name: Cavadini - first_name: Anton full_name: Sabantsev, Anton last_name: Sabantsev - first_name: Georg full_name: Kempf, Georg last_name: Kempf - first_name: Ganesh R. full_name: Pathare, Ganesh R. last_name: Pathare - first_name: Klaus full_name: Brackmann, Klaus last_name: Brackmann - first_name: Alicia full_name: Michael, Alicia id: 6437c950-2a03-11ee-914d-d6476dd7b75c last_name: Michael orcid: 0000-0002-6080-839X - first_name: Lukas full_name: Kater, Lukas last_name: Kater - first_name: Eric full_name: Hietter-Pfeiffer, Eric last_name: Hietter-Pfeiffer - first_name: Mina full_name: Haddawi, Mina last_name: Haddawi - first_name: Urja P. full_name: Kuber, Urja P. last_name: Kuber - first_name: Sandra full_name: Mühlhäusser, Sandra last_name: Mühlhäusser - first_name: Ralph S. full_name: Grand, Ralph S. last_name: Grand - first_name: Michael B. full_name: Stadler, Michael B. last_name: Stadler - first_name: Sebastian full_name: Deindl, Sebastian last_name: Deindl - first_name: Nicolas H. full_name: Thomä, Nicolas H. last_name: Thomä citation: ama: Weiss J, Vecchia L, Domjan D, et al. The human BAF chromatin remodeler processes nucleosomes bound by pioneer transcription factors OCT4–SOX2. Molecular Cell. 2026;86(4):625-639.e8. doi:10.1016/j.molcel.2026.01.021 apa: Weiss, J., Vecchia, L., Domjan, D., Cavadini, S., Sabantsev, A., Kempf, G., … Thomä, N. H. (2026). The human BAF chromatin remodeler processes nucleosomes bound by pioneer transcription factors OCT4–SOX2. Molecular Cell. Cell Press. https://doi.org/10.1016/j.molcel.2026.01.021 chicago: Weiss, Joscha, Luca Vecchia, David Domjan, Simone Cavadini, Anton Sabantsev, Georg Kempf, Ganesh R. Pathare, et al. “The Human BAF Chromatin Remodeler Processes Nucleosomes Bound by Pioneer Transcription Factors OCT4–SOX2.” Molecular Cell. Cell Press, 2026. https://doi.org/10.1016/j.molcel.2026.01.021. ieee: J. Weiss et al., “The human BAF chromatin remodeler processes nucleosomes bound by pioneer transcription factors OCT4–SOX2,” Molecular Cell, vol. 86, no. 4. Cell Press, p. 625–639.e8, 2026. ista: Weiss J, Vecchia L, Domjan D, Cavadini S, Sabantsev A, Kempf G, Pathare GR, Brackmann K, Michael AK, Kater L, Hietter-Pfeiffer E, Haddawi M, Kuber UP, Mühlhäusser S, Grand RS, Stadler MB, Deindl S, Thomä NH. 2026. The human BAF chromatin remodeler processes nucleosomes bound by pioneer transcription factors OCT4–SOX2. Molecular Cell. 86(4), 625–639.e8. mla: Weiss, Joscha, et al. “The Human BAF Chromatin Remodeler Processes Nucleosomes Bound by Pioneer Transcription Factors OCT4–SOX2.” Molecular Cell, vol. 86, no. 4, Cell Press, 2026, p. 625–639.e8, doi:10.1016/j.molcel.2026.01.021. short: J. Weiss, L. Vecchia, D. Domjan, S. Cavadini, A. Sabantsev, G. Kempf, G.R. Pathare, K. Brackmann, A.K. Michael, L. Kater, E. Hietter-Pfeiffer, M. Haddawi, U.P. Kuber, S. Mühlhäusser, R.S. Grand, M.B. Stadler, S. Deindl, N.H. Thomä, Molecular Cell 86 (2026) 625–639.e8. date_created: 2026-03-30T11:58:48Z date_published: 2026-02-19T00:00:00Z date_updated: 2026-10-20T08:57:55Z day: '19' ddc: - '570' department: - _id: AlMi doi: 10.1016/j.molcel.2026.01.021 external_id: pmid: - '41679301' file: - access_level: open_access checksum: e16a7315b64a706184b177ea1621523c content_type: application/pdf creator: dernst date_created: 2026-03-30T12:04:38Z date_updated: 2026-03-30T12:04:38Z file_id: '21510' file_name: 2026_MolecularCell_Weiss.pdf file_size: 9786677 relation: main_file success: 1 file_date_updated: 2026-03-30T12:04:38Z fulldoi: https://doi.org/10.1016/j.molcel.2026.01.021 has_accepted_license: '1' intvolume: ' 86' issue: '4' language: - iso: eng month: '02' oa: 1 oa_version: Published Version page: 625-639.e8 pmid: 1 publication: Molecular Cell publication_identifier: issn: - 1097-2765 publication_status: published publisher: Cell Press quality_controlled: '1' scopus_import: '1' status: public title: The human BAF chromatin remodeler processes nucleosomes bound by pioneer transcription factors OCT4–SOX2 tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 86 year: '2026' ... --- OA_place: publisher OA_type: hybrid _id: '21761' abstract: - lang: eng text: Neural tube closure is a critical morphogenetic process in vertebrate development, and failure to close cranial regions such as the hindbrain neuropore (HNP) leads to severe congenital malformations. While mechanical forces such as actomyosin purse-string contraction and directional cell crawling have been implicated in driving HNP closure, how these forces organize local cell shape and motion to produce large-scale tissue remodeling remains poorly understood. Using live and fixed imaging of mouse embryos combined with cell-based biophysical modeling, we show that these force-generating mechanisms are insufficient to explain the reproducible patterns of cell elongation and nematic alignment observed at the HNP border. Instead, we show that local anisotropic stress and cytoskeletal organization are required to generate these patterns and promote midline cell motion. Our model captures key features of cell shape dynamics and emergent nematic order, which we confirm experimentally, including the alignment of actin fibers with cell shape and enhanced midline cell speed. Comparative analysis with chick embryos, which lack supracellular purse strings, supports a conserved link between tension generation and cellular patterning. These findings establish a physical framework connecting force generation, cell shape anisotropy, and tissue morphodynamics during epithelial gap closure. acknowledgement: S.B. acknowledges support from the National Institutes of Health (NIH R35 GM143042) and the National Science Foundation (NSF MCB-2203601). G.L.G. acknowledges support from the Wellcome Trust (211112/Z/18/Z), the Royal Society (RG\R2\232082), and the Leverhulme Trust (RPG-2024-147). E.M. acknowledges support from European Union’s Horizon 2021 Marie Sklodowska-Curie grant agreement no. 101067028. F.P.-V. acknowledges support from the NOMIS foundation. The surface subtraction macro is courtesy of Dr. Dale Moulding and available on GitHub (https://github.com/DaleMoulding/Fiji-Macros). article_processing_charge: Yes (in subscription journal) article_type: original author: - first_name: Fernanda L full_name: Perez Verdugo, Fernanda L id: 4ecec223-9070-11ef-a0a9-bc76077bea8d last_name: Perez Verdugo - first_name: Eirini full_name: Maniou, Eirini last_name: Maniou - first_name: Gabriel L. full_name: Galea, Gabriel L. last_name: Galea - first_name: Shiladitya full_name: Banerjee, Shiladitya last_name: Banerjee citation: ama: Perez Verdugo FL, Maniou E, Galea GL, Banerjee S. Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis. Current Biology. 2026;36(8):1903-1917.e5. doi:10.1016/j.cub.2026.02.068 apa: Perez Verdugo, F. L., Maniou, E., Galea, G. L., & Banerjee, S. (2026). Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis. Current Biology. Cell Press. https://doi.org/10.1016/j.cub.2026.02.068 chicago: Perez Verdugo, Fernanda L, Eirini Maniou, Gabriel L. Galea, and Shiladitya Banerjee. “Mechanosensitive Feedback Organizes Cell Shape and Motion during Hindbrain Neuropore Morphogenesis.” Current Biology. Cell Press, 2026. https://doi.org/10.1016/j.cub.2026.02.068. ieee: F. L. Perez Verdugo, E. Maniou, G. L. Galea, and S. Banerjee, “Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis,” Current Biology, vol. 36, no. 8. Cell Press, p. 1903–1917.e5, 2026. ista: Perez Verdugo FL, Maniou E, Galea GL, Banerjee S. 2026. Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis. Current Biology. 36(8), 1903–1917.e5. mla: Perez Verdugo, Fernanda L., et al. “Mechanosensitive Feedback Organizes Cell Shape and Motion during Hindbrain Neuropore Morphogenesis.” Current Biology, vol. 36, no. 8, Cell Press, 2026, p. 1903–1917.e5, doi:10.1016/j.cub.2026.02.068. short: F.L. Perez Verdugo, E. Maniou, G.L. Galea, S. Banerjee, Current Biology 36 (2026) 1903–1917.e5. date_created: 2026-04-26T22:01:46Z date_published: 2026-04-20T00:00:00Z date_updated: 2026-10-20T08:59:48Z day: '20' ddc: - '570' department: - _id: AnSa doi: 10.1016/j.cub.2026.02.068 external_id: pmid: - '41881011' file: - access_level: open_access checksum: 80ae45457b4682c50c84f54de15aa9a8 content_type: application/pdf creator: dernst date_created: 2026-04-28T13:13:40Z date_updated: 2026-04-28T13:13:40Z file_id: '21774' file_name: 2026_CurrentBiology_PerezVerdugo.pdf file_size: 13402043 relation: main_file success: 1 file_date_updated: 2026-04-28T13:13:40Z fulldoi: https://doi.org/10.1016/j.cub.2026.02.068 has_accepted_license: '1' intvolume: ' 36' issue: '8' language: - iso: eng month: '04' oa: 1 oa_version: Published Version page: 1903-1917.e5 pmid: 1 publication: Current Biology publication_identifier: eissn: - 1879-0445 issn: - 0960-9822 publication_status: published publisher: Cell Press quality_controlled: '1' scopus_import: '1' status: public title: Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis tmp: image: /images/cc_by_nc_nd.png legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) short: CC BY-NC-ND (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 36 year: '2026' ... --- OA_place: repository OA_type: green _id: '21955' abstract: - lang: eng text: 'AgRP neurons cause hunger, the drive to seek and consume food. Their activation by fasting is key for survival and is thought to be triggered by feedback when energy stores are low. However, we know that environmental cues can also regulate AgRP neurons since cues that predict future food intake rapidly inhibit AgRP neurons, but is the converse true: can the prediction of future fasting rapidly activate AgRP neurons? Here, we show in mice that such rapid fasting activation of AgRP neurons does occur. This rapid activation is driven by excitatory input from paraventricular hypothalamic (PVH) neurons expressing Sim2, which are bidirectionally sensitive to predictions of future energy state. Thus, cognitively processed contextual information conveyed by PVHSim2 neurons strongly activates AgRP neurons. Lastly, chronic silencing of PVHSim2 neurons causes persistent hypophagia. This PVHSim2-to-AgRP-neuron circuit, by anticipating and preventing negative energy balance, provides an important new dimension of hunger regulation.' acknowledgement: "We thank all members of the B.B.L. laboratory for helpful discussions. We\r\nthank the BADERC and BNORC transgenic cores (NIH P30DK057521 and\r\nP30DK046200) for performing embryo injections to generate knockin mouse\r\nlines. We also thank the BIDMC Energy Balance Core (supported by NIH\r\nS10OD028635 and the Boston Area Diabetes Endocrinology Research Centers, P30DK135043), where Marissa Cortopassi performed indirect calorimetry experiments and Alexander Banks assisted with data analysis and interpretation. Confocal imaging was performed at BIDMC’s Confocal Imaging\r\nCore. We thank Chen Wu for assistance in designing knockin mouse lines.\r\nThis work was supported by the NIH (R01DK134427, R01DK096010, and\r\nR01DK075632 to B.B.L.). Authors were supported by an EMBO Long-Term\r\nFellowship (770-2018, S.J.W.), a T32 Postdoctoral Training Fellowship\r\n(5T32DK007516, E.D.L.), the Charles A. King Trust Postdoctoral Research\r\nFellowship program (A.M.D.), and a K99 Career Development Award\r\n(K99HL144923, J.M.R.)." article_processing_charge: No article_type: original author: - first_name: Samuel J. full_name: Walker, Samuel J. last_name: Walker - first_name: Elijah D. full_name: Lowenstein, Elijah D. last_name: Lowenstein - first_name: Amelia May Barnett full_name: Douglass, Amelia May Barnett id: de5f6fda-80fb-11ef-996f-a8c4ecd8e289 last_name: Douglass orcid: 0000-0001-5398-6473 - first_name: Callum M.P. full_name: Thomas, Callum M.P. last_name: Thomas - first_name: Joseph C. full_name: Madara, Joseph C. last_name: Madara - first_name: Hakan full_name: Kucukdereli, Hakan last_name: Kucukdereli - first_name: Eunice A. full_name: Barbosa-Meillon, Eunice A. last_name: Barbosa-Meillon - first_name: Jenkang full_name: Tao, Jenkang last_name: Tao - first_name: Jon M. full_name: Resch, Jon M. last_name: Resch - first_name: Bradford B. full_name: Lowell, Bradford B. last_name: Lowell citation: ama: Walker SJ, Lowenstein ED, Douglass AM, et al. A hypothalamic circuit for anticipating future changes in energy balance. Neuron. doi:10.1016/j.neuron.2026.05.010 apa: Walker, S. J., Lowenstein, E. D., Douglass, A. M., Thomas, C. M. P., Madara, J. C., Kucukdereli, H., … Lowell, B. B. (n.d.). A hypothalamic circuit for anticipating future changes in energy balance. Neuron. Cell Press. https://doi.org/10.1016/j.neuron.2026.05.010 chicago: Walker, Samuel J., Elijah D. Lowenstein, Amelia M. Douglass, Callum M.P. Thomas, Joseph C. Madara, Hakan Kucukdereli, Eunice A. Barbosa-Meillon, Jenkang Tao, Jon M. Resch, and Bradford B. Lowell. “A Hypothalamic Circuit for Anticipating Future Changes in Energy Balance.” Neuron. Cell Press, n.d. https://doi.org/10.1016/j.neuron.2026.05.010. ieee: S. J. Walker et al., “A hypothalamic circuit for anticipating future changes in energy balance,” Neuron. Cell Press. ista: Walker SJ, Lowenstein ED, Douglass AM, Thomas CMP, Madara JC, Kucukdereli H, Barbosa-Meillon EA, Tao J, Resch JM, Lowell BB. A hypothalamic circuit for anticipating future changes in energy balance. Neuron. mla: Walker, Samuel J., et al. “A Hypothalamic Circuit for Anticipating Future Changes in Energy Balance.” Neuron, Cell Press, doi:10.1016/j.neuron.2026.05.010. short: S.J. Walker, E.D. Lowenstein, A.M. Douglass, C.M.P. Thomas, J.C. Madara, H. Kucukdereli, E.A. Barbosa-Meillon, J. Tao, J.M. Resch, B.B. Lowell, Neuron (n.d.). date_created: 2026-06-08T09:24:25Z date_published: 2026-06-03T00:00:00Z date_updated: 2026-10-20T09:00:02Z day: '03' department: - _id: AmDo doi: 10.1016/j.neuron.2026.05.010 external_id: pmid: - '42235510' fulldoi: https://doi.org/10.1016/j.neuron.2026.05.010 keyword: - hunger - hypothalamus - AGRP neurons - neuroscience - metabolism - homeostasis - feeding - food intake - energy balance - appetite language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.1101/2025.09.27.678865 month: '06' oa: 1 oa_version: Preprint pmid: 1 publication: Neuron publication_identifier: eissn: - ' 1097-4199' issn: - 0896-6273 publication_status: inpress publisher: Cell Press quality_controlled: '1' scopus_import: '1' status: public title: A hypothalamic circuit for anticipating future changes in energy balance type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 year: '2026' ... --- OA_type: closed access _id: '22144' abstract: - lang: eng text: Most cells polarize and migrate in response to electrical fields. In this issue of Cell, Belliveau et al. identify TMEM154/Galvanin, a receptor that serves as a cellular antenna to sense electrical gradients and guide migration toward the cathode. article_processing_charge: No article_type: comment author: - first_name: Michael full_name: Riedl, Michael id: 3BE60946-F248-11E8-B48F-1D18A9856A87 last_name: Riedl orcid: 0000-0003-4844-6311 - first_name: Michael K full_name: Sixt, Michael K id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87 last_name: Sixt orcid: 0000-0002-6620-9179 citation: ama: Riedl M, Sixt MK. A new sense for electrical fields. Cell. 2026;189(13):3845-3846. doi:10.1016/j.cell.2026.05.038 apa: Riedl, M., & Sixt, M. K. (2026). A new sense for electrical fields. Cell. Cell Press. https://doi.org/10.1016/j.cell.2026.05.038 chicago: Riedl, Michael, and Michael K Sixt. “A New Sense for Electrical Fields.” Cell. Cell Press, 2026. https://doi.org/10.1016/j.cell.2026.05.038. ieee: M. Riedl and M. K. Sixt, “A new sense for electrical fields,” Cell, vol. 189, no. 13. Cell Press, pp. 3845–3846, 2026. ista: Riedl M, Sixt MK. 2026. A new sense for electrical fields. Cell. 189(13), 3845–3846. mla: Riedl, Michael, and Michael K. Sixt. “A New Sense for Electrical Fields.” Cell, vol. 189, no. 13, Cell Press, 2026, pp. 3845–46, doi:10.1016/j.cell.2026.05.038. short: M. Riedl, M.K. Sixt, Cell 189 (2026) 3845–3846. corr_author: '1' das_tickbox: '0' date_created: 2026-06-28T22:01:34Z date_published: 2026-06-25T00:00:00Z date_updated: 2026-10-20T09:00:16Z day: '25' department: - _id: MiSi doi: 10.1016/j.cell.2026.05.038 fulldoi: https://doi.org/10.1016/j.cell.2026.05.038 intvolume: ' 189' issue: '13' language: - iso: eng month: '06' oa_version: None page: 3845-3846 publication: Cell publication_identifier: eissn: - 1097-4172 issn: - 0092-8674 publication_status: published publisher: Cell Press quality_controlled: '1' researchdata_availability: no scopus_import: '1' status: public supplementarymaterial: no title: A new sense for electrical fields type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 189 year: '2026' ... --- OA_type: closed access _id: '20972' abstract: - lang: eng text: Small amounts of stress are thought to have beneficial effects. A new study reports a mechanism by which the psychedelic drug, psilocybin, causes acute release of stress hormones, despite its known long-term anti-anxiety effects. article_processing_charge: No article_type: letter_note author: - first_name: Hakan full_name: Kücükdereli, Hakan id: 5d5f6ea4-ef9e-11f0-a10a-85e12a3552af last_name: Kücükdereli - first_name: Amelia May Barnett full_name: Douglass, Amelia May Barnett id: de5f6fda-80fb-11ef-996f-a8c4ecd8e289 last_name: Douglass orcid: 0000-0001-5398-6473 citation: ama: 'Kücükdereli H, Douglass AM. Neuroscience: What doesn’t kill you makes you stronger. Current Biology. 2026;36(1):R27-R29. doi:10.1016/j.cub.2025.11.056' apa: 'Kücükdereli, H., & Douglass, A. M. (2026). Neuroscience: What doesn’t kill you makes you stronger. Current Biology. Cell Press. https://doi.org/10.1016/j.cub.2025.11.056' chicago: 'Kücükdereli, Hakan, and Amelia M. Douglass. “Neuroscience: What Doesn’t Kill You Makes You Stronger.” Current Biology. Cell Press, 2026. https://doi.org/10.1016/j.cub.2025.11.056.' ieee: 'H. Kücükdereli and A. M. Douglass, “Neuroscience: What doesn’t kill you makes you stronger,” Current Biology, vol. 36, no. 1. Cell Press, pp. R27–R29, 2026.' ista: 'Kücükdereli H, Douglass AM. 2026. Neuroscience: What doesn’t kill you makes you stronger. Current Biology. 36(1), R27–R29.' mla: 'Kücükdereli, Hakan, and Amelia M. Douglass. “Neuroscience: What Doesn’t Kill You Makes You Stronger.” Current Biology, vol. 36, no. 1, Cell Press, 2026, pp. R27–29, doi:10.1016/j.cub.2025.11.056.' short: H. Kücükdereli, A.M. Douglass, Current Biology 36 (2026) R27–R29. corr_author: '1' date_created: 2026-01-11T23:01:33Z date_published: 2026-01-05T00:00:00Z date_updated: 2026-10-20T08:57:26Z day: '05' department: - _id: AmDo - _id: SiHi doi: 10.1016/j.cub.2025.11.056 external_id: pmid: - '41494523' fulldoi: https://doi.org/10.1016/j.cub.2025.11.056 intvolume: ' 36' issue: '1' language: - iso: eng month: '01' oa_version: None page: R27-R29 pmid: 1 publication: Current Biology publication_identifier: eissn: - 1879-0445 issn: - 0960-9822 publisher: Cell Press quality_controlled: '1' scopus_import: '1' status: public title: 'Neuroscience: What doesn’t kill you makes you stronger' type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 36 year: '2026' ... --- OA_place: publisher OA_type: hybrid PlanS_conform: '1' _id: '20859' abstract: - lang: eng text: Effective immune responses rely on the efficient migration of leukocytes. Yet, how temperature regulates migration dynamics at the single-cell level has remained poorly understood. Using zebrafish embryos and mouse tissue explants, we found that temperature positively regulates leukocyte migration speed, exploration, and arrival frequencies to wounds and lymph vessels. Complementary 2D and 3D cultures revealed that this thermokinetic control of cell migration is conserved across immune cell types, independently of the 3D tissue environment. By applying precise (sub-)cellular temperature modulation, we identified a rapid and reversible thermo-response that depends on myosin II activity. Small physiological increases in temperature (1°C –2°C), as present during fever-like conditions, profoundly increased immune responses by accelerating arrival times at lymphatic vessels and tissue wounds. These findings identify myosin-II-dependent actomyosin contractility as a critical mechanical structure regulating single-cell thermo-adaptability, with physiological implications for tuning the speed of immune responses in vivo. acknowledged_ssus: - _id: NanoFab acknowledgement: 'The authors would like to acknowledge the Super Resolution Light Microcopy and Nanoscopy (SLN) Facility of ICFO for their support with imaging experiments, Johann Osmond (Nanofabrication laboratory, ICFO) for the design and production of molds for generating confinement coverslip, Merche Rivas for cell culture of immune cells and further support from the CRG Core Facilities for Genomics and Advanced Light Microscopy. We would like to thank Michael Sixt for discussions on this work and the Quidant, Ruprecht, and Wieser lab members for critical reading of the manuscript. This research was supported by the Scientific Service Units (SSU) of IST-Austria through resources provided by the Nanofabrication Facility (NFF). C.A. acknowledges the funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement no 847517 and V.V. from the ICFOstepstone – PhD Programme funded by the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement no 665884. S.W. acknowledges support through the Spanish Ministry of Economy and Competitiveness via MINECO’s Plan Nacional (BFU2017-86296-P). V.R. acknowledges funding from the European Union’s HORIZON-EIC-2021-PATHFINDEROPEN program under grant agreement no. 101046620 and European Union''s Horizon Europe program under the grant agreement no. 101072123. E.K. acknowledges funding by a fellowship of the Ministry of Innovation, Science and Research of North-Rhine-Westphalia (AZ: 421-8.03.03.02-137069) and the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy – EXC 2151 – 390873048 and by the TRA Life and Health (University of Bonn) as part of the Excellence Strategy of the federal and state governments.' article_processing_charge: Yes (in subscription journal) article_type: original author: - first_name: Iván full_name: Company-Garrido, Iván last_name: Company-Garrido - first_name: Alberto full_name: Zurita Carpio, Alberto last_name: Zurita Carpio - first_name: Mariona full_name: Colomer-Rosell, Mariona last_name: Colomer-Rosell - first_name: Bernard full_name: Ciraulo, Bernard last_name: Ciraulo - first_name: Ronja full_name: Molkenbur, Ronja last_name: Molkenbur - first_name: Peter full_name: Lanzerstorfer, Peter last_name: Lanzerstorfer - first_name: Fabio full_name: Pezzano, Fabio last_name: Pezzano - first_name: Costanza full_name: Agazzi, Costanza last_name: Agazzi - first_name: Robert full_name: Hauschild, Robert id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87 last_name: Hauschild orcid: 0000-0001-9843-3522 - first_name: Saumey full_name: Jain, Saumey last_name: Jain - first_name: Jeroen M. full_name: Jacques, Jeroen M. last_name: Jacques - first_name: Valeria full_name: Venturini, Valeria last_name: Venturini - first_name: Christian full_name: Knapp, Christian last_name: Knapp - first_name: Yufei full_name: Xie, Yufei last_name: Xie - first_name: Jack full_name: Merrin, Jack id: 4515C308-F248-11E8-B48F-1D18A9856A87 last_name: Merrin orcid: 0000-0001-5145-4609 - first_name: Julian full_name: Weghuber, Julian last_name: Weghuber - first_name: Marcel full_name: Schaaf, Marcel last_name: Schaaf - first_name: Romain full_name: Quidant, Romain last_name: Quidant - first_name: Eva full_name: Kiermaier, Eva id: 3EB04B78-F248-11E8-B48F-1D18A9856A87 last_name: Kiermaier orcid: 0000-0001-6165-5738 - first_name: Jaime full_name: Ortega Arroyo, Jaime last_name: Ortega Arroyo - first_name: Verena full_name: Ruprecht, Verena id: 4D71A03A-F248-11E8-B48F-1D18A9856A87 last_name: Ruprecht orcid: 0000-0003-4088-8633 - first_name: Stefan full_name: Wieser, Stefan id: 355AA5A0-F248-11E8-B48F-1D18A9856A87 last_name: Wieser orcid: 0000-0002-2670-2217 citation: ama: Company-Garrido I, Zurita Carpio A, Colomer-Rosell M, et al. Myosin II regulates cellular thermo-adaptability and the efficiency of immune responses. Developmental Cell. 2026;61(2):356-371.e12. doi:10.1016/j.devcel.2025.10.006 apa: Company-Garrido, I., Zurita Carpio, A., Colomer-Rosell, M., Ciraulo, B., Molkenbur, R., Lanzerstorfer, P., … Wieser, S. (2026). Myosin II regulates cellular thermo-adaptability and the efficiency of immune responses. Developmental Cell. Cell Press. https://doi.org/10.1016/j.devcel.2025.10.006 chicago: Company-Garrido, Iván, Alberto Zurita Carpio, Mariona Colomer-Rosell, Bernard Ciraulo, Ronja Molkenbur, Peter Lanzerstorfer, Fabio Pezzano, et al. “Myosin II Regulates Cellular Thermo-Adaptability and the Efficiency of Immune Responses.” Developmental Cell. Cell Press, 2026. https://doi.org/10.1016/j.devcel.2025.10.006. ieee: I. Company-Garrido et al., “Myosin II regulates cellular thermo-adaptability and the efficiency of immune responses,” Developmental Cell, vol. 61, no. 2. Cell Press, p. 356–371.e12, 2026. ista: Company-Garrido I, Zurita Carpio A, Colomer-Rosell M, Ciraulo B, Molkenbur R, Lanzerstorfer P, Pezzano F, Agazzi C, Hauschild R, Jain S, Jacques JM, Venturini V, Knapp C, Xie Y, Merrin J, Weghuber J, Schaaf M, Quidant R, Kiermaier E, Ortega Arroyo J, Ruprecht V, Wieser S. 2026. Myosin II regulates cellular thermo-adaptability and the efficiency of immune responses. Developmental Cell. 61(2), 356–371.e12. mla: Company-Garrido, Iván, et al. “Myosin II Regulates Cellular Thermo-Adaptability and the Efficiency of Immune Responses.” Developmental Cell, vol. 61, no. 2, Cell Press, 2026, p. 356–371.e12, doi:10.1016/j.devcel.2025.10.006. short: I. Company-Garrido, A. Zurita Carpio, M. Colomer-Rosell, B. Ciraulo, R. Molkenbur, P. Lanzerstorfer, F. Pezzano, C. Agazzi, R. Hauschild, S. Jain, J.M. Jacques, V. Venturini, C. Knapp, Y. Xie, J. Merrin, J. Weghuber, M. Schaaf, R. Quidant, E. Kiermaier, J. Ortega Arroyo, V. Ruprecht, S. Wieser, Developmental Cell 61 (2026) 356–371.e12. das_tickbox: '1' dataavailabilitystatement: "This study did not generate new unique reagents. Data are available upon request.\r\n•The custom-made codes used in this study are available at: https://github.com/mcolomerr/cell_thermo https://github.com/Stefan1980sol/Lymph_entry_simu\r\n• Any additional information required to reanalyze the data reported in this paper is available from the lead contact upon request." date_created: 2025-12-28T23:01:27Z date_published: 2026-02-11T00:00:00Z date_updated: 2026-10-20T09:01:14Z day: '11' ddc: - '570' department: - _id: Bio - _id: NanoFab doi: 10.1016/j.devcel.2025.10.006 external_id: pmid: - '41192429' file: - access_level: open_access checksum: 52fd52d2d19a4514f8fcc1b40f420ca2 content_type: application/pdf creator: dernst date_created: 2026-07-23T06:26:25Z date_updated: 2026-07-23T06:26:25Z file_id: '22388' file_name: 2026_DevelopmentalCell_CompanyGarrido.pdf file_size: 12342817 relation: main_file success: 1 file_date_updated: 2026-07-23T06:26:25Z fulldoi: https://doi.org/10.1016/j.devcel.2025.10.006 has_accepted_license: '1' intvolume: ' 61' issue: '2' keyword: - thermobiology - cell migration - thermo-adaptability of immune cells language: - iso: eng month: '02' oa: 1 oa_version: Published Version page: 356-371.e12 pmid: 1 publication: Developmental Cell publication_identifier: eissn: - 1878-1551 issn: - 1534-5807 publication_status: published publisher: Cell Press quality_controlled: '1' researchdata_availability: upon request scopus_import: '1' status: public supplementarymaterial: yes title: Myosin II regulates cellular thermo-adaptability and the efficiency of immune responses tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 61 year: '2026' ... --- OA_place: publisher OA_type: hybrid PlanS_conform: '1' _id: '20935' abstract: - lang: eng text: In situ cryo-electron tomography (cryo-ET) has emerged as the method of choice to investigate the structures of biomolecules in their native context. However, challenges remain for the efficient production and sharing of large-scale cryo-ET datasets. Here, we combined cryogenic plasma-based focused ion beam (cryo-PFIB) milling with recent advances in cryo-ET acquisition and processing to generate a dataset of 1,829 annotated tomograms of the green alga Chlamydomonas reinhardtii, which we provide as a community resource to drive method development and inspire biological discovery. To assay data quality, we performed subtomogram averaging of both soluble and membrane-bound complexes ranging in size from >3 MDa to ∼200 kDa, including 80S ribosomes, Rubisco, nucleosomes, microtubules, clathrin, photosystem II, and mitochondrial ATP synthase. The majority of these density maps reached sub-nanometer resolution, demonstrating the potential of this C. reinhardtii dataset as well as the promise of modern cryo-ET workflows and open data sharing to empower visual proteomics. acknowledgement: Calculations were performed at the Max Planck Institute of Biochemistry and the Raven Supercomputer of the Max Planck Computing and Data Facility (MPCDF) in Garching, Germany; at the sciCORE (http://scicore.unibas.ch/) scientific computing center at the University of Basel, Switzerland; and at Thermo Fisher Scientific, in Eindhoven, the Netherlands. This work was supported by Thermo Fisher Scientific. All lamella preparations and tilt-series collections used in this work were conducted at Thermo Fisher R&D facilities in Brno and Eindhoven, utilizing Arctis and Krios microscopes. This work was also supported by the ERC consolidator grant “cryOcean” (fulfilled by the Swiss State Secretariat for Education, Research and Innovation, M822.00045) as well as a Swiss Nanoscience Institute PhD school grant to B.D.E. and P.V.d.S., an EMBO long-term postdoctoral fellowship (ALTF-383-2022) to G.T., an SNSF Postdoctoral Fellowship (project 210561) to F.W., a Boehringer Ingelheim Fonds fellowship to L.L., and by the Max Planck Society to J.A.G.B. and J.M.P. article_processing_charge: Yes (in subscription journal) article_type: original author: - first_name: Ron full_name: Kelley, Ron last_name: Kelley - first_name: Sagar full_name: Khavnekar, Sagar last_name: Khavnekar - first_name: Ricardo D. full_name: Righetto, Ricardo D. last_name: Righetto - first_name: Jessica full_name: Heebner, Jessica last_name: Heebner - first_name: Martin full_name: Obr, Martin id: 4741CA5A-F248-11E8-B48F-1D18A9856A87 last_name: Obr orcid: 0000-0003-1756-6564 - first_name: Xianjun full_name: Zhang, Xianjun last_name: Zhang - first_name: Saikat full_name: Chakraborty, Saikat last_name: Chakraborty - first_name: Grigory full_name: Tagiltsev, Grigory last_name: Tagiltsev - first_name: Alicia full_name: Michael, Alicia id: 6437c950-2a03-11ee-914d-d6476dd7b75c last_name: Michael orcid: 0000-0002-6080-839X - first_name: Sofie full_name: Van Dorst, Sofie last_name: Van Dorst - first_name: Florent full_name: Waltz, Florent last_name: Waltz - first_name: Caitlyn L. full_name: Mccafferty, Caitlyn L. last_name: Mccafferty - first_name: Lorenz full_name: Lamm, Lorenz last_name: Lamm - first_name: Simon full_name: Zufferey, Simon last_name: Zufferey - first_name: Philippe full_name: Van Der Stappen, Philippe last_name: Van Der Stappen - first_name: Hugo full_name: Van Den Hoek, Hugo last_name: Van Den Hoek - first_name: Wojciech full_name: Wietrzynski, Wojciech last_name: Wietrzynski - first_name: Pavol full_name: Harar, Pavol id: e03d953a-6e8c-11ef-99e4-f0717d385cd5 last_name: Harar orcid: 0000-0001-5206-1794 - first_name: William full_name: Wan, William last_name: Wan - first_name: John A.G. full_name: Briggs, John A.G. last_name: Briggs - first_name: Jürgen M. full_name: Plitzko, Jürgen M. last_name: Plitzko - first_name: Benjamin D. full_name: Engel, Benjamin D. last_name: Engel - first_name: Abhay full_name: Kotecha, Abhay last_name: Kotecha citation: ama: Kelley R, Khavnekar S, Righetto RD, et al. Toward community-driven visual proteomics with large-scale cryo-electron tomography of Chlamydomonas reinhardtii. Molecular Cell. 2026;86(1):213-230.e7. doi:10.1016/j.molcel.2025.11.029 apa: Kelley, R., Khavnekar, S., Righetto, R. D., Heebner, J., Obr, M., Zhang, X., … Kotecha, A. (2026). Toward community-driven visual proteomics with large-scale cryo-electron tomography of Chlamydomonas reinhardtii. Molecular Cell. Cell Press. https://doi.org/10.1016/j.molcel.2025.11.029 chicago: Kelley, Ron, Sagar Khavnekar, Ricardo D. Righetto, Jessica Heebner, Martin Obr, Xianjun Zhang, Saikat Chakraborty, et al. “Toward Community-Driven Visual Proteomics with Large-Scale Cryo-Electron Tomography of Chlamydomonas Reinhardtii.” Molecular Cell. Cell Press, 2026. https://doi.org/10.1016/j.molcel.2025.11.029. ieee: R. Kelley et al., “Toward community-driven visual proteomics with large-scale cryo-electron tomography of Chlamydomonas reinhardtii,” Molecular Cell, vol. 86, no. 1. Cell Press, p. 213–230.e7, 2026. ista: Kelley R, Khavnekar S, Righetto RD, Heebner J, Obr M, Zhang X, Chakraborty S, Tagiltsev G, Michael AK, Van Dorst S, Waltz F, Mccafferty CL, Lamm L, Zufferey S, Van Der Stappen P, Van Den Hoek H, Wietrzynski W, Harar P, Wan W, Briggs JAG, Plitzko JM, Engel BD, Kotecha A. 2026. Toward community-driven visual proteomics with large-scale cryo-electron tomography of Chlamydomonas reinhardtii. Molecular Cell. 86(1), 213–230.e7. mla: Kelley, Ron, et al. “Toward Community-Driven Visual Proteomics with Large-Scale Cryo-Electron Tomography of Chlamydomonas Reinhardtii.” Molecular Cell, vol. 86, no. 1, Cell Press, 2026, p. 213–230.e7, doi:10.1016/j.molcel.2025.11.029. short: R. Kelley, S. Khavnekar, R.D. Righetto, J. Heebner, M. Obr, X. Zhang, S. Chakraborty, G. Tagiltsev, A.K. Michael, S. Van Dorst, F. Waltz, C.L. Mccafferty, L. Lamm, S. Zufferey, P. Van Der Stappen, H. Van Den Hoek, W. Wietrzynski, P. Harar, W. Wan, J.A.G. Briggs, J.M. Plitzko, B.D. Engel, A. Kotecha, Molecular Cell 86 (2026) 213–230.e7. das_tickbox: '1' dataavailabilitystatement: "Raw EM data are available at the EMPIAR under accession code EMPIAR: EMPIAR-11830. Annotation and processing information for all 1,829 tomograms are provided in spreadsheet format.153 The following subtomogram averages have been deposited at the Electron Microscopy Data Bank (EMDB): 80S ribosome (EMDB: EMD-51847), nucleosome (EMDB: EMD-19906), PSII (EMDB: EMD-51731), Rubisco (EMDB: EMD-51848), microtubule (EMDB: EMD-51804), clathrin (EMDB: EMD-51789), and ATP synthase (EMDB: EMD-51802). Segmentations shown in Figures 2 and 3 are deposited on Zenodo (https://doi.org/10.5281/zenodo.15875785). Particle positions and orientations used for STA, along with all resources derived from this work, are available on GitHub (https://github.com/Chromatin-Structure-Rhythms-Lab/ChlamyAnnotations). Reconstructed tomograms and annotations are also available to explore interactively at the CZII Cryo-ET Data Portal (DS-10302, https://cryoetdataportal.czscience.com/datasets/10302/). Raw data for cryo-PFIB/SEM slice-and-view of a whole C. reinhardtii cell has also been deposited (EMPIAR: EMPIAR-11275).\r\n\r\nThis paper does not report original code.\r\n\r\nAny additional information required to reanalyze the data reported in this paper is available from the lead contact upon request." date_created: 2026-01-04T23:01:36Z date_published: 2026-01-08T00:00:00Z date_updated: 2026-10-20T09:02:52Z day: '08' ddc: - '570' department: - _id: AlMi doi: 10.1016/j.molcel.2025.11.029 file: - access_level: open_access checksum: 96a2f8519124d1a0d9de8d2594bf7147 content_type: application/pdf creator: dernst date_created: 2026-07-28T07:38:45Z date_updated: 2026-07-28T07:38:45Z file_id: '22599' file_name: 2026_MolecularCell_Kelley.pdf file_size: 26749637 relation: main_file success: 1 file_date_updated: 2026-07-28T07:38:45Z fulldoi: https://doi.org/10.1016/j.molcel.2025.11.029 has_accepted_license: '1' intvolume: ' 86' issue: '1' language: - iso: eng month: '01' oa: 1 oa_version: Published Version page: 213-230.e7 publication: Molecular Cell publication_identifier: eissn: - 1097-4164 issn: - 1097-2765 publication_status: published publisher: Cell Press quality_controlled: '1' researchdata_availability: yes scopus_import: '1' status: public supplementarymaterial: yes title: Toward community-driven visual proteomics with large-scale cryo-electron tomography of Chlamydomonas reinhardtii tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 86 year: '2026' ... --- OA_place: publisher OA_type: hybrid PlanS_conform: '1' _id: '20986' abstract: - lang: eng text: During complex vocal interactions, different features of acoustic stimuli are integrated to produce appropriate vocal responses,1 such as copying sounds during vocal matching behavior in some animals.2,3,4,5,6,7,8,9,10,11,12 However, little is known about the interplay and possible trade-offs between the different temporal and spectral acoustic features during these vocal exchanges.2,13,14 Nightingales can flexibly match the pitch of their tonal “whistle songs” in real time during counter-singing duels.15,16 Here, we show that the syllable duration of whistle playbacks could alter the song responses of wild nightingales, causing their whistle duration distribution to shift toward the presented stimulus duration. When exposed to whistle playbacks featuring unnatural combinations of pitch and duration, nightingales demonstrate a flexible trade-off between pitch matching and temporal imitation, yet they are constrained by their vocal repertoire. They selectively adapted their vocal responses to approximate these novel stimuli, aligning them with their natural whistle repertoire. We developed a computational model of nightingale whistle-matching behavior that revealed a hierarchical organization of acoustic feature production. During whistle matching, the feature integration process is constrained by the duration of syllables, and pitch matching follows within this temporal framework, forcing a trade-off between the two features. Our findings reveal a complex interplay between the spectral and temporal domains that shapes song-matching behavior. acknowledgement: 'We would like to thank J. Benichov and N. Hein for their help with fieldwork; M. Ramadas for helping with the segmentation analysis; T. Eliav, C. Chintaluri, G. Tkacik, and A. Navas for providing helpful comments to the project and manuscript; and A. Costalunga for the drawings of nightingales. Funding sources: The Joachim Herz Stiftung Add-on Fellowships for Interdisciplinary Life Science, awarded to G.C.; the ERC Consolidator Grant 819603 SYNAPSEEK, awarded to T.P.V.; and DFG Research Unit 5768–532521431, DFG Research Grant-547921981, DFG SFB 1315–327654276, and the ERC Starting Grant 757459 MIDNIGHT, awarded to D.V.' article_processing_charge: Yes (in subscription journal) article_type: original author: - first_name: Juan Sebastian full_name: Calderon Garcia, Juan Sebastian id: 1271b54b-dbcd-11ea-9d1d-d92da838fe2c last_name: Calderon Garcia - first_name: Giacomo full_name: Costalunga, Giacomo last_name: Costalunga - first_name: Tim P full_name: Vogels, Tim P id: CB6FF8D2-008F-11EA-8E08-2637E6697425 last_name: Vogels orcid: 0000-0003-3295-6181 - first_name: Daniela full_name: Vallentin, Daniela last_name: Vallentin citation: ama: Calderon Garcia JS, Costalunga G, Vogels TP, Vallentin D. Interplay between syllable duration and pitch during whistle matching in wild nightingales. Current Biology. 2026;36(3):791-798.e6. doi:10.1016/j.cub.2025.12.025 apa: Calderon Garcia, J. S., Costalunga, G., Vogels, T. P., & Vallentin, D. (2026). Interplay between syllable duration and pitch during whistle matching in wild nightingales. Current Biology. Cell Press. https://doi.org/10.1016/j.cub.2025.12.025 chicago: Calderon Garcia, Juan Sebastian, Giacomo Costalunga, Tim P Vogels, and Daniela Vallentin. “Interplay between Syllable Duration and Pitch during Whistle Matching in Wild Nightingales.” Current Biology. Cell Press, 2026. https://doi.org/10.1016/j.cub.2025.12.025. ieee: J. S. Calderon Garcia, G. Costalunga, T. P. Vogels, and D. Vallentin, “Interplay between syllable duration and pitch during whistle matching in wild nightingales,” Current Biology, vol. 36, no. 3. Cell Press, p. 791–798.e6, 2026. ista: Calderon Garcia JS, Costalunga G, Vogels TP, Vallentin D. 2026. Interplay between syllable duration and pitch during whistle matching in wild nightingales. Current Biology. 36(3), 791–798.e6. mla: Calderon Garcia, Juan Sebastian, et al. “Interplay between Syllable Duration and Pitch during Whistle Matching in Wild Nightingales.” Current Biology, vol. 36, no. 3, Cell Press, 2026, p. 791–798.e6, doi:10.1016/j.cub.2025.12.025. short: J.S. Calderon Garcia, G. Costalunga, T.P. Vogels, D. Vallentin, Current Biology 36 (2026) 791–798.e6. das_tickbox: '1' dataavailabilitystatement: "All data have been deposited at https://github.com/vallentinlab/NG-whistle-durations and are publicly available as of the date of publication.\r\nAll original code has been deposited at https://github.com/vallentinlab/NG-whistle-durations and is publicly available as of the date of publication.\r\nAny additional information required to reanalyze the data reported in this paper is available from the lead contact upon request." date_created: 2026-01-14T12:00:29Z date_published: 2026-02-02T00:00:00Z date_updated: 2026-10-20T09:02:18Z day: '02' ddc: - '570' - '577' department: - _id: GradSch - _id: TiVo doi: 10.1016/j.cub.2025.12.025 ec_funded: 1 external_id: pmid: - '41529680' file: - access_level: open_access checksum: e17c3537193d5ab4886596d1a04f9b0e content_type: application/pdf creator: dernst date_created: 2026-07-27T10:47:55Z date_updated: 2026-07-27T10:47:55Z file_id: '22416' file_name: 2026_CurrentBiology_CalderonGarcia.pdf file_size: 7120959 relation: main_file success: 1 file_date_updated: 2026-07-27T10:47:55Z fulldoi: https://doi.org/10.1016/j.cub.2025.12.025 has_accepted_license: '1' intvolume: ' 36' issue: '3' language: - iso: eng month: '02' oa: 1 oa_version: Published Version page: 791-798.e6 pmid: 1 project: - _id: 0aacfa84-070f-11eb-9043-d7eb2c709234 call_identifier: H2020 grant_number: '819603' name: Learning the shape of synaptic plasticity rules for neuronal architectures and function through machine learning. publication: Current Biology publication_identifier: eissn: - 1879-0445 issn: - 0960-9822 publication_status: published publisher: Cell Press quality_controlled: '1' researchdata_availability: yes scopus_import: '1' status: public supplementarymaterial: yes title: Interplay between syllable duration and pitch during whistle matching in wild nightingales tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 36 year: '2026' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: gold PlanS_conform: '1' _id: '21502' abstract: - lang: eng text: The mammalian brain stores glucose, the main circulating energy substrate, as glycogen. In rodents, the cerebellum contains relatively high glycogen levels, yet its cellular and subcellular distribution remains poorly defined. Using monoclonal antibodies against glycogen, we examined its distribution in the mouse cerebellar cortex. Glycogen was predominantly localized to Bergmann glia (BG) processes in the molecular layer and was also detected in Purkinje cells (PCs), the principal cerebellar neurons. To assess the functional significance of cerebellar glycogen, we analyzed behavior in mice lacking glycogen synthase 1 (Gys1) in BG or PCs using a floxed Gys1 line. Gys1 deficiency in either PCs or GFAP-positive cells reduced anxiety-like behavior, whereas combined deletion caused PC degeneration and ataxia. These findings reveal a critical role for glycogen metabolism in both astrocytes and neurons in cerebellar function. acknowledgement: This work was supported by the Novo Nordisk Foundation (NNFOC0058058, H. Hirase), the Danmarks Frie Forskningsfond (0134-00107B and 5283-00069A, H.Hirase), the Lundbeck Foundation, Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research (KAKENHI) program (22K06454/24H01221, A.K.; 23K27482, H.Hirai), the Japan Agency for Medical Research and Development (AMED) Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS) (JP21dm0207111, H. Hirai), AMED Brain/MINDS 2.0 (JP23wm0625001 and JP24wm0625103, H. Hirai), and grants from the Spanish Ministerio de Ciencia e Innovación (MCIU/FEDER/AEI) (PID2020-118699 GB-100, J.D.) and the Fundación Ramón Areces (J.D.). Sonam Akther has been supported by the RIKEN IPA fellowship. We are thankful to Dr. Yuki Oe for his support in the initial stage of this study and to Dan Xue for his help with the graphical abstract. We thank Dr. Pia Weikop for providing CTN research infrastructure. The authors declare no competing financial interests. article_number: '115192' article_processing_charge: Yes article_type: original author: - first_name: Sonam full_name: Akther, Sonam last_name: Akther - first_name: Ashley Bomin full_name: Lee, Ashley Bomin last_name: Lee - first_name: Ayumu full_name: Konno, Ayumu last_name: Konno - first_name: Antonis full_name: Asiminas, Antonis last_name: Asiminas - first_name: Marta full_name: Vittani, Marta last_name: Vittani - first_name: Tsuneko full_name: Mishima, Tsuneko last_name: Mishima - first_name: Hirokazu full_name: Hirai, Hirokazu last_name: Hirai - first_name: Claire Francesca full_name: Meehan, Claire Francesca last_name: Meehan - first_name: Jordi full_name: Duran, Jordi last_name: Duran - first_name: Joan full_name: Guinovart, Joan last_name: Guinovart - first_name: Hitoshi full_name: Ashida, Hitoshi last_name: Ashida - first_name: Tsuyoshi full_name: Morita, Tsuyoshi last_name: Morita - first_name: Otto full_name: Baba, Otto last_name: Baba - first_name: Ryuichi full_name: Shigemoto, Ryuichi id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 - first_name: Maiken full_name: Nedergaard, Maiken last_name: Nedergaard - first_name: Hajime full_name: Hirase, Hajime last_name: Hirase citation: ama: Akther S, Lee AB, Konno A, et al. Distribution and functional significance of rodent cerebellar glycogen. iScience. 2026;29(4). doi:10.1016/j.isci.2026.115192 apa: Akther, S., Lee, A. B., Konno, A., Asiminas, A., Vittani, M., Mishima, T., … Hirase, H. (2026). Distribution and functional significance of rodent cerebellar glycogen. IScience. Cell Press. https://doi.org/10.1016/j.isci.2026.115192 chicago: Akther, Sonam, Ashley Bomin Lee, Ayumu Konno, Antonis Asiminas, Marta Vittani, Tsuneko Mishima, Hirokazu Hirai, et al. “Distribution and Functional Significance of Rodent Cerebellar Glycogen.” IScience. Cell Press, 2026. https://doi.org/10.1016/j.isci.2026.115192. ieee: S. Akther et al., “Distribution and functional significance of rodent cerebellar glycogen,” iScience, vol. 29, no. 4. Cell Press, 2026. ista: Akther S, Lee AB, Konno A, Asiminas A, Vittani M, Mishima T, Hirai H, Meehan CF, Duran J, Guinovart J, Ashida H, Morita T, Baba O, Shigemoto R, Nedergaard M, Hirase H. 2026. Distribution and functional significance of rodent cerebellar glycogen. iScience. 29(4), 115192. mla: Akther, Sonam, et al. “Distribution and Functional Significance of Rodent Cerebellar Glycogen.” IScience, vol. 29, no. 4, 115192, Cell Press, 2026, doi:10.1016/j.isci.2026.115192. short: S. Akther, A.B. Lee, A. Konno, A. Asiminas, M. Vittani, T. Mishima, H. Hirai, C.F. Meehan, J. Duran, J. Guinovart, H. Ashida, T. Morita, O. Baba, R. Shigemoto, M. Nedergaard, H. Hirase, IScience 29 (2026). das_tickbox: '1' dataavailabilitystatement: "This study did not generate new materials or reagents.All data supporting the findings of this study are available from the lead contact upon reasonable request.\r\nThis study did not generate any new code.\r\nAdditional raw data can be obtained from the lead contact upon reasonable request." date_created: 2026-03-29T22:07:07Z date_published: 2026-04-17T00:00:00Z date_updated: 2026-10-20T09:02:33Z day: '17' ddc: - '570' department: - _id: RySh doi: 10.1016/j.isci.2026.115192 external_id: pmid: - '41890976' file: - access_level: open_access checksum: 9c9ccc87072d04808e4af407d647ed20 content_type: application/pdf creator: dernst date_created: 2026-07-27T12:03:23Z date_updated: 2026-07-27T12:03:23Z file_id: '22427' file_name: 2026_iScience_Akther.pdf file_size: 14469960 relation: main_file success: 1 file_date_updated: 2026-07-27T12:03:23Z fulldoi: https://doi.org/10.1016/j.isci.2026.115192 has_accepted_license: '1' intvolume: ' 29' issue: '4' language: - iso: eng month: '04' oa: 1 oa_version: Published Version pmid: 1 publication: iScience publication_identifier: eissn: - 2589-0042 publication_status: published publisher: Cell Press quality_controlled: '1' researchdata_availability: upon request scopus_import: '1' status: public supplementarymaterial: no title: Distribution and functional significance of rodent cerebellar glycogen tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 29 year: '2026' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: gold PlanS_conform: '1' _id: '20924' abstract: - lang: eng text: "Pioneer transcription factors (TFs) possess the ability to read out DNA motifs embedded within nucleosomes, driving changes in gene expression during cellular differentiation and reprogramming. Here, we present selected engagement on nucleosome sequencing (SeEN-seq), a protocol designed to systematically identify potential TF-binding sites on the nucleosome. We describe steps for nucleosome library assembly, SeEN-seq assay, and cryoelectron microscopy (cryo-EM) sample preparation. This protocol facilitates the preparation of homogeneous pioneer TF-nucleosome complexes for cryo-EM structure determination using single-particle analysis.\r\nFor complete details on the use and execution of this protocol, please refer to Michael et al.1" acknowledgement: We thank R.H. Kim, A. Casper, and R. Gautsch for sequencing at the NGS facility (RRID:SCR_025746). K.T. is an Honorary Professor at the Department of Biology, Ludwig-Maximilians-University, Munich, Germany. This study was funded by European Research Council grant ERC-CoG-818556 TotipotentZygotChrom (K.T.), Max Planck Society (K.T.), and ERC Starting Grant “ChromaChrono” 101162145 (A.K.M.). article_number: '104295' article_processing_charge: Yes article_type: original author: - first_name: Wataru full_name: Kobayashi, Wataru last_name: Kobayashi - first_name: Alicia full_name: Michael, Alicia id: 6437c950-2a03-11ee-914d-d6476dd7b75c last_name: Michael orcid: 0000-0002-6080-839X - first_name: Siwat full_name: Ruangroengkulrith, Siwat last_name: Ruangroengkulrith - first_name: Maximilian full_name: Kümmecke, Maximilian last_name: Kümmecke - first_name: Kikuë full_name: Tachibana, Kikuë last_name: Tachibana citation: ama: Kobayashi W, Michael AK, Ruangroengkulrith S, Kümmecke M, Tachibana K. Protocol for integrative analysis of transcription factor-nucleosome interactions using SeEN-seq and cryo-EM structure determination. STAR Protocols. 2026;7(1). doi:10.1016/j.xpro.2025.104295 apa: Kobayashi, W., Michael, A. K., Ruangroengkulrith, S., Kümmecke, M., & Tachibana, K. (2026). Protocol for integrative analysis of transcription factor-nucleosome interactions using SeEN-seq and cryo-EM structure determination. STAR Protocols. Cell Press. https://doi.org/10.1016/j.xpro.2025.104295 chicago: Kobayashi, Wataru, Alicia K. Michael, Siwat Ruangroengkulrith, Maximilian Kümmecke, and Kikuë Tachibana. “Protocol for Integrative Analysis of Transcription Factor-Nucleosome Interactions Using SeEN-Seq and Cryo-EM Structure Determination.” STAR Protocols. Cell Press, 2026. https://doi.org/10.1016/j.xpro.2025.104295. ieee: W. Kobayashi, A. K. Michael, S. Ruangroengkulrith, M. Kümmecke, and K. Tachibana, “Protocol for integrative analysis of transcription factor-nucleosome interactions using SeEN-seq and cryo-EM structure determination,” STAR Protocols, vol. 7, no. 1. Cell Press, 2026. ista: Kobayashi W, Michael AK, Ruangroengkulrith S, Kümmecke M, Tachibana K. 2026. Protocol for integrative analysis of transcription factor-nucleosome interactions using SeEN-seq and cryo-EM structure determination. STAR Protocols. 7(1), 104295. mla: Kobayashi, Wataru, et al. “Protocol for Integrative Analysis of Transcription Factor-Nucleosome Interactions Using SeEN-Seq and Cryo-EM Structure Determination.” STAR Protocols, vol. 7, no. 1, 104295, Cell Press, 2026, doi:10.1016/j.xpro.2025.104295. short: W. Kobayashi, A.K. Michael, S. Ruangroengkulrith, M. Kümmecke, K. Tachibana, STAR Protocols 7 (2026). corr_author: '1' das_tickbox: '1' dataavailabilitystatement: Raw SeEN-seq data of ESRRB nucleosome binding have been deposited on the Sequence Read Achieve database under the accession PRJNA1305216. Example analysis scripts and input files for SeEN-seq analysis can be found at https://doi.org/10.5281/zenodo.17665082. date_created: 2026-01-04T23:01:33Z date_published: 2026-03-20T00:00:00Z date_updated: 2026-10-20T09:01:26Z day: '20' ddc: - '570' department: - _id: AlMi doi: 10.1016/j.xpro.2025.104295 external_id: pmid: - '41455105' file: - access_level: open_access checksum: cf04b061a48548a649e6a2435bf120db content_type: application/pdf creator: dernst date_created: 2026-07-23T06:33:24Z date_updated: 2026-07-23T06:33:24Z file_id: '22389' file_name: 2026_StarProtocols_Kobayashi.pdf file_size: 5531906 relation: main_file success: 1 file_date_updated: 2026-07-23T06:33:24Z fulldoi: https://doi.org/10.1016/j.xpro.2025.104295 has_accepted_license: '1' intvolume: ' 7' issue: '1' language: - iso: eng month: '03' oa: 1 oa_version: Published Version pmid: 1 project: - _id: 9136c684-16d5-11f0-9cad-91c0177b365f grant_number: '101162145' name: Circadian structural transitions of chromatin publication: STAR Protocols publication_identifier: eissn: - 2666-1667 publication_status: published publisher: Cell Press quality_controlled: '1' researchdata_availability: yes scopus_import: '1' status: public supplementarymaterial: yes title: Protocol for integrative analysis of transcription factor-nucleosome interactions using SeEN-seq and cryo-EM structure determination tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 7 year: '2026' ... --- OA_place: publisher OA_type: hybrid PlanS_conform: '1' _id: '20725' abstract: - lang: eng text: The canonical mechanism by which the phytohormone auxin regulates transcription has been one of the cornerstones of plant signaling. The recent unexpected discovery of cyclic AMP (cAMP) as a second messenger in this pathway has revised its foundations while leaving many open questions and gaps in our understanding; these will be discussed in this forum article. acknowledgement: I apologize to colleagues whose relevant work I was unable to cite due to space limitations. This work was funded by the European Union (ERC, CYNIPS, 101142681) and Austrian Science Fund (FWF; 37051-B). I thank Drs Huihuang Chen, Yuanrong Pei, Jason Reed, Linlin Qi, and Dolf Weijers for inspiration and critical input. article_processing_charge: Yes (via OA deal) article_type: review author: - first_name: Jiří full_name: Friml, Jiří id: 4159519E-F248-11E8-B48F-1D18A9856A87 last_name: Friml orcid: 0000-0002-8302-7596 citation: ama: 'Friml J. Role of cAMP in TIR1/AFB auxin signaling: Open issues. Trends in Plant Science. 2026;31(2):136-138. doi:10.1016/j.tplants.2025.10.018' apa: 'Friml, J. (2026). Role of cAMP in TIR1/AFB auxin signaling: Open issues. Trends in Plant Science. Cell Press. https://doi.org/10.1016/j.tplants.2025.10.018' chicago: 'Friml, Jiří. “Role of CAMP in TIR1/AFB Auxin Signaling: Open Issues.” Trends in Plant Science. Cell Press, 2026. https://doi.org/10.1016/j.tplants.2025.10.018.' ieee: 'J. Friml, “Role of cAMP in TIR1/AFB auxin signaling: Open issues,” Trends in Plant Science, vol. 31, no. 2. Cell Press, pp. 136–138, 2026.' ista: 'Friml J. 2026. Role of cAMP in TIR1/AFB auxin signaling: Open issues. Trends in Plant Science. 31(2), 136–138.' mla: 'Friml, Jiří. “Role of CAMP in TIR1/AFB Auxin Signaling: Open Issues.” Trends in Plant Science, vol. 31, no. 2, Cell Press, 2026, pp. 136–38, doi:10.1016/j.tplants.2025.10.018.' short: J. Friml, Trends in Plant Science 31 (2026) 136–138. corr_author: '1' das_tickbox: '0' date_created: 2025-12-02T16:29:22Z date_published: 2026-02-01T00:00:00Z date_updated: 2026-10-20T09:01:46Z day: '01' ddc: - '580' department: - _id: JiFr doi: 10.1016/j.tplants.2025.10.018 external_id: pmid: - '41249070' file: - access_level: open_access checksum: e60e903fb4b3e917dba763976ec652cd content_type: application/pdf creator: dernst date_created: 2026-07-27T08:26:40Z date_updated: 2026-07-27T08:26:40Z file_id: '22413' file_name: 2026_TrendsPlantScience_Friml.pdf file_size: 432792 relation: main_file success: 1 file_date_updated: 2026-07-27T08:26:40Z fulldoi: https://doi.org/10.1016/j.tplants.2025.10.018 has_accepted_license: '1' intvolume: ' 31' issue: '2' language: - iso: eng month: '02' oa: 1 oa_version: Published Version page: 136-138 pmid: 1 project: - _id: 8f347782-16d5-11f0-9cad-8c19706ee739 grant_number: '101142681' name: Cyclic nucleotides as second messengers in plants - _id: 7bcece63-9f16-11ee-852c-ae94e099eeb6 grant_number: P37051 name: Guanylate cyclase activity of TIR1/AFBs auxin receptors publication: Trends in Plant Science publication_identifier: eissn: - 1878-4372 issn: - 1360-1385 publication_status: published publisher: Cell Press quality_controlled: '1' researchdata_availability: no scopus_import: '1' status: public supplementarymaterial: no title: 'Role of cAMP in TIR1/AFB auxin signaling: Open issues' tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 31 year: '2026' ... --- OA_type: closed access _id: '20636' abstract: - lang: eng text: The versatile and pivotal roles of the phytohormone auxin in regulating plant growth and development are typically linked to its directional transport, relying on the polarized PIN-FORMED (PIN) auxin exporters at the plasma membrane (PM). For decades, auxin has been proposed to promote PIN polarization, generating self-regulatory feedback mediating much of plant development, but mechanistic insight into this regulation is lacking. Here, we uncover an auxin-induced protein complex at the PM, containing auxin co-receptors transmembrane kinases (TMKs) and PIN1 auxin exporter, as the core machinery that underlies this feedback regulation. Auxin promotes PIN1 phosphorylation by TMKs, modulating PIN1 polarization and transport activity. We also provide evidence that PIN1-exported extracellular auxin is crucial for TMK activation and cell elongation, thus forming the simplest two-element self-regulatory feedback circuit. Thus, these findings offer direct mechanistic insights into a potential self-organizing circuit for auxin signaling and transport to ensure proper plant development in Arabidopsis. acknowledgement: We thank Lukáš Fiedler‬ for helping with the writing. This work was supported by the National Key Research and Development Program of China (2023YFA0913500) to T.X., R.H., Y.Y., Y.X., and M.W. and by the National Natural Science Foundation of China grants to T.X. (32130010), Z.Y. (3241101698), and R.H. (32070309 and 32470276) and startup funds from the Fujian Agriculture and Forestry University and the Shanghai Plant Stress Biology Center, Chinese Academy of Sciences to T.X. article_processing_charge: No article_type: original author: - first_name: R full_name: Huang, R last_name: Huang - first_name: J full_name: Wang, J last_name: Wang - first_name: M full_name: Chang, M last_name: Chang - first_name: W full_name: Tang, W last_name: Tang - first_name: Y full_name: Yu, Y last_name: Yu - first_name: Y full_name: Zhang, Y last_name: Zhang - first_name: Y full_name: Peng, Y last_name: Peng - first_name: Y full_name: Wang, Y last_name: Wang - first_name: Y full_name: Guo, Y last_name: Guo - first_name: T full_name: Lu, T last_name: Lu - first_name: Y full_name: Cao, Y last_name: Cao - first_name: Y full_name: Zhou, Y last_name: Zhou - first_name: Q full_name: Zhang, Q last_name: Zhang - first_name: Y full_name: Huang, Y last_name: Huang - first_name: A full_name: Wu, A last_name: Wu - first_name: L full_name: Ren, L last_name: Ren - first_name: Michelle C full_name: Gallei, Michelle C id: 35A03822-F248-11E8-B48F-1D18A9856A87 last_name: Gallei orcid: 0000-0003-1286-7368 - first_name: J full_name: Dong, J last_name: Dong - first_name: H full_name: Chen, H last_name: Chen - first_name: J full_name: He, J last_name: He - first_name: M full_name: Wen, M last_name: Wen - first_name: Jiří full_name: Friml, Jiří id: 4159519E-F248-11E8-B48F-1D18A9856A87 last_name: Friml orcid: 0000-0002-8302-7596 - first_name: L full_name: Sun, L last_name: Sun - first_name: Y full_name: Xiong, Y last_name: Xiong - first_name: Z full_name: Yang, Z last_name: Yang - first_name: T full_name: Xu, T last_name: Xu citation: ama: Huang R, Wang J, Chang M, et al. TMK-PIN1 drives a short self-organizing circuit for auxin export and signaling in Arabidopsis. Developmental Cell. 2026;61(1):73-84. doi:10.1016/j.devcel.2025.09.009 apa: Huang, R., Wang, J., Chang, M., Tang, W., Yu, Y., Zhang, Y., … Xu, T. (2026). TMK-PIN1 drives a short self-organizing circuit for auxin export and signaling in Arabidopsis. Developmental Cell. Cell Press. https://doi.org/10.1016/j.devcel.2025.09.009 chicago: Huang, R, J Wang, M Chang, W Tang, Y Yu, Y Zhang, Y Peng, et al. “TMK-PIN1 Drives a Short Self-Organizing Circuit for Auxin Export and Signaling in Arabidopsis.” Developmental Cell. Cell Press, 2026. https://doi.org/10.1016/j.devcel.2025.09.009. ieee: R. Huang et al., “TMK-PIN1 drives a short self-organizing circuit for auxin export and signaling in Arabidopsis,” Developmental Cell, vol. 61, no. 1. Cell Press, pp. 73–84, 2026. ista: Huang R, Wang J, Chang M, Tang W, Yu Y, Zhang Y, Peng Y, Wang Y, Guo Y, Lu T, Cao Y, Zhou Y, Zhang Q, Huang Y, Wu A, Ren L, Gallei MC, Dong J, Chen H, He J, Wen M, Friml J, Sun L, Xiong Y, Yang Z, Xu T. 2026. TMK-PIN1 drives a short self-organizing circuit for auxin export and signaling in Arabidopsis. Developmental Cell. 61(1), 73–84. mla: Huang, R., et al. “TMK-PIN1 Drives a Short Self-Organizing Circuit for Auxin Export and Signaling in Arabidopsis.” Developmental Cell, vol. 61, no. 1, Cell Press, 2026, pp. 73–84, doi:10.1016/j.devcel.2025.09.009. short: R. Huang, J. Wang, M. Chang, W. Tang, Y. Yu, Y. Zhang, Y. Peng, Y. Wang, Y. Guo, T. Lu, Y. Cao, Y. Zhou, Q. Zhang, Y. Huang, A. Wu, L. Ren, M.C. Gallei, J. Dong, H. Chen, J. He, M. Wen, J. Friml, L. Sun, Y. Xiong, Z. Yang, T. Xu, Developmental Cell 61 (2026) 73–84. das_tickbox: '1' dataavailabilitystatement: "Plasmids and genetic materials generated in this study will be made available upon request from the lead contact.The mass spectrometry data reported in this work have been deposited at the iProX database. Original western blot gel images have been deposited to Mendeley Data. The accession code and the DOI are listed in the key resources table.\r\nThis paper does not report original code. Any additional information required to reanalyze the data reported in this paper is available from the lead contact upon request." date_created: 2025-11-12T10:03:39Z date_published: 2026-01-14T00:00:00Z date_updated: 2026-10-20T09:02:01Z day: '14' department: - _id: JiFr doi: 10.1016/j.devcel.2025.09.009 external_id: pmid: - '41043435' fulldoi: https://doi.org/10.1016/j.devcel.2025.09.009 intvolume: ' 61' issue: '1' language: - iso: eng month: '01' oa_version: None page: 73-84 pmid: 1 publication: Developmental Cell publication_identifier: eissn: - 1878-1551 issn: - 1534-5807 publication_status: published publisher: Cell Press quality_controlled: '1' researchdata_availability: upon request scopus_import: '1' status: public supplementarymaterial: yes title: TMK-PIN1 drives a short self-organizing circuit for auxin export and signaling in Arabidopsis type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 61 year: '2026' ... --- OA_type: closed access _id: '22286' abstract: - lang: eng text: Plants are remarkable organisms. Unlike animals, they cannot flee and, rooted in one place, they must cope with whatever challenges arise — nutrient scarcity, drought, shade, wind or obstacles in the soil. Their extraordinary ability to survive in such unstable environmental conditions lies in their capacity to adapt. In response to environmental signals, plants can rapidly adjust the rate of organ growth, change the direction of growth, bend toward resources, or remodel their body architecture by promoting or suppressing the formation of new organs such as lateral roots, branches, leaves, or flowers. This unique developmental plasticity depends on chemical signals, plant hormones that serve as regulators and coordinators of endogenous molecular and cellular processes. Chief among these signals is auxin, a plant hormone central to nearly every aspect of plant life. article_processing_charge: No article_type: original author: - first_name: Valentin full_name: Leitner, Valentin id: 4c665ce3-0016-11ec-bea0-e44de7a4fa3d last_name: Leitner - first_name: Eva full_name: Benková, Eva id: 38F4F166-F248-11E8-B48F-1D18A9856A87 last_name: Benková orcid: 0000-0002-8510-9739 citation: ama: Leitner V, Benková E. Auxin and the control of plant growth and development. Current Biology. 2026;36(13):R739-R744. doi:10.1016/j.cub.2026.04.047 apa: Leitner, V., & Benková, E. (2026). Auxin and the control of plant growth and development. Current Biology. Cell Press. https://doi.org/10.1016/j.cub.2026.04.047 chicago: Leitner, Valentin, and Eva Benková. “Auxin and the Control of Plant Growth and Development.” Current Biology. Cell Press, 2026. https://doi.org/10.1016/j.cub.2026.04.047. ieee: V. Leitner and E. Benková, “Auxin and the control of plant growth and development,” Current Biology, vol. 36, no. 13. Cell Press, pp. R739–R744, 2026. ista: Leitner V, Benková E. 2026. Auxin and the control of plant growth and development. Current Biology. 36(13), R739–R744. mla: Leitner, Valentin, and Eva Benková. “Auxin and the Control of Plant Growth and Development.” Current Biology, vol. 36, no. 13, Cell Press, 2026, pp. R739–44, doi:10.1016/j.cub.2026.04.047. short: V. Leitner, E. Benková, Current Biology 36 (2026) R739–R744. corr_author: '1' das_tickbox: '0' date_created: 2026-07-13T09:39:40Z date_published: 2026-07-06T00:00:00Z date_updated: 2026-10-20T09:00:35Z day: '06' department: - _id: EvBe - _id: GradSch doi: 10.1016/j.cub.2026.04.047 external_id: pmid: - '42407441' fulldoi: https://doi.org/10.1016/j.cub.2026.04.047 intvolume: ' 36' issue: '13' language: - iso: eng month: '07' oa_version: None page: R739-R744 pmid: 1 publication: Current Biology publication_identifier: issn: - 0960-9822 publication_status: published publisher: Cell Press quality_controlled: '1' researchdata_availability: no scopus_import: '1' status: public supplementarymaterial: no title: Auxin and the control of plant growth and development type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 36 year: '2026' ... --- OA_type: closed access _id: '22305' abstract: - lang: eng text: Active dendrites enrich the repertoire of single-neuron computations. Whereas a lot is known about the function of dendrites in vitro, information about their in vivo properties is limited. A new study1 uses advanced imaging to study hippocampal CA1 pyramidal neuron dendrites in head-fixed, awake animals. article_processing_charge: No article_type: letter_note author: - first_name: Subhodeep full_name: Bhattacharya, Subhodeep id: 45f74010-66f6-11f0-a7d4-c441fa3685ff last_name: Bhattacharya orcid: 0009-0009-0334-9068 - first_name: Peter M full_name: Jonas, Peter M id: 353C1B58-F248-11E8-B48F-1D18A9856A87 last_name: Jonas orcid: 0000-0001-5001-4804 citation: ama: Bhattacharya S, Jonas PM. Mission impossible? Quantitative analysis of dendritic computations in vivo. Neuron. 2026;114(10):1706-1708. doi:10.1016/j.neuron.2026.04.002 apa: Bhattacharya, S., & Jonas, P. M. (2026). Mission impossible? Quantitative analysis of dendritic computations in vivo. Neuron. Cell Press. https://doi.org/10.1016/j.neuron.2026.04.002 chicago: Bhattacharya, Subhodeep, and Peter M Jonas. “Mission Impossible? Quantitative Analysis of Dendritic Computations in Vivo.” Neuron. Cell Press, 2026. https://doi.org/10.1016/j.neuron.2026.04.002. ieee: S. Bhattacharya and P. M. Jonas, “Mission impossible? Quantitative analysis of dendritic computations in vivo,” Neuron, vol. 114, no. 10. Cell Press, pp. 1706–1708, 2026. ista: Bhattacharya S, Jonas PM. 2026. Mission impossible? Quantitative analysis of dendritic computations in vivo. Neuron. 114(10), 1706–1708. mla: Bhattacharya, Subhodeep, and Peter M. Jonas. “Mission Impossible? Quantitative Analysis of Dendritic Computations in Vivo.” Neuron, vol. 114, no. 10, Cell Press, 2026, pp. 1706–08, doi:10.1016/j.neuron.2026.04.002. short: S. Bhattacharya, P.M. Jonas, Neuron 114 (2026) 1706–1708. corr_author: '1' das_tickbox: '0' date_created: 2026-07-13T10:51:27Z date_published: 2026-05-20T00:00:00Z date_updated: 2026-10-20T09:00:56Z day: '20' department: - _id: PeJo doi: 10.1016/j.neuron.2026.04.002 external_id: pmid: - '42161246' fulldoi: https://doi.org/10.1016/j.neuron.2026.04.002 intvolume: ' 114' issue: '10' language: - iso: eng month: '05' oa_version: None page: 1706-1708 pmid: 1 publication: Neuron publication_identifier: issn: - 0896-6273 publication_status: published publisher: Cell Press quality_controlled: '1' researchdata_availability: no scopus_import: '1' status: public supplementarymaterial: no title: Mission impossible? Quantitative analysis of dendritic computations in vivo type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 114 year: '2026' ...