@inproceedings{20300,
  abstract     = {Simultaneously addressing multiple objectives is becoming increasingly important in modern machine learning. At the same time, data is often high-dimensional and costly to label. For a single objective such as prediction risk, conventional regularization techniques are known to improve generalization when the data exhibits low-dimensional structure like sparsity. However, it is largely unexplored how to leverage this structure in the context of multi-objective learning (MOL) with multiple competing objectives. In this work, we discuss how the application of vanilla regularization approaches can fail, and propose a two-stage MOL framework that can successfully leverage low-dimensional structure. We demonstrate its effectiveness experimentally for multi-distribution learning and fairness-risk trade-offs.},
  author       = {Wegel, Tobias and Kovačević, Filip and Ţifrea, Alexandru and Yang, Fanny},
  booktitle    = {The 28th International Conference on Artificial Intelligence and Statistics},
  issn         = {2640-3498},
  location     = {Mai Khao, Thailand},
  pages        = {4591--4599},
  publisher    = {ML Research Press},
  title        = {{Learning Pareto manifolds in high dimensions: How can regularization help?}},
  volume       = {258},
  year         = {2025},
}

@inproceedings{20301,
  abstract     = {We study privately releasing column sums of a d-dimensional table with entries from a universe χ undergoing T row updates, called histogram under continual release. Our mechanisms give better additive ℓ∞-error than existing mechanisms for a large class of queries and input streams. Our first contribution is an output-sensitive mechanism in the insertions-only model (χ = {0, 1}) for maintaining (i) the histogram or (ii) queries that do not require maintaining the entire histogram, such as the maximum or minimum column sum, the median, or any quantiles. The mechanism has an additive error of O(d log2 (dq∗) + log T) whp, where q∗ is the maximum output value over all time steps on this dataset. The mechanism does not require q∗ as input. This breaks the Ω(d log T) bound of prior work when q∗ ≪ T. Our second contribution is a mechanism for the turnstile model that admits negative entry updates (χ = {−1, 0, 1}). This mechanism has an additive error of O(d log2(dK) + log T) whp, where K is the number of times two consecutive data rows differ, and the mechanism does not require K as input. This is useful when monitoring inputs that only vary under unusual circumstances. For d = 1 this gives the first
private mechanism with error O(log2 K + log T) for continual counting in the turnstile model, improving on the O(log2 n + log T) error bound by Dwork et al. (2015), where n is the number of ones in the stream, as well as allowing negative entries, while Dwork et al. (2015) can only handle nonnegative entries (χ = {0, 1}). },
  author       = {Henzinger, Monika H and Sricharan, A. R. and Steiner, Teresa Anna},
  booktitle    = {The 28th International Conference on Artificial Intelligence and Statistics},
  issn         = {2640-3498},
  location     = {Mai Khao, Thailand},
  pages        = {1990--1998},
  publisher    = {ML Research Press},
  title        = {{Differentially private continual release of histograms and related queries}},
  volume       = {258},
  year         = {2025},
}

@inproceedings{20303,
  abstract     = {Observational genome-wide association studies are now widely used for causal inference in genetic epidemiology. To maintain privacy, such data is often only publicly available as summary statistics, and often studies for the endogenous covariates and the outcome are available separately. This has necessitated methods tailored to two-sample summary statistics. Current state-of-the-art methods modify linear instrumental variable (IV) regression---with genetic variants as instruments---to account for unmeasured confounding. However, since the endogenous covariates can be high dimensional, standard IV assumptions are generally insufficient to identify all causal effects simultaneously. We ensure identifiability by assuming the causal effects are sparse and propose a sparse causal effect two-sample IV estimator, spaceTSIV, adapting the spaceIV estimator by Pfister and Peters (2022) for two-sample summary statistics. We provide two methods, based on L0- and L1-penalization, respectively. We prove identifiability of the sparse causal effects in the two-sample setting and consistency of spaceTSIV. The performance of spaceTSIV is compared with existing two-sample IV methods in simulations. Finally, we showcase our methods using real proteomic and gene-expression data for drug-target discovery.},
  author       = {Huang, Shimeng and Pfister, Niklas and Bowden, Jack},
  booktitle    = {The 28th International Conference on Artificial Intelligence and Statistics},
  issn         = {2640-3498},
  location     = {Mai Khao, Thailand},
  pages        = {3394--3402},
  publisher    = {ML Research Press},
  title        = {{Sparse causal effect estimation using two-sample summary statistics in the presence of unmeasured confounding}},
  volume       = {258},
  year         = {2025},
}

@article{20318,
  abstract     = {Lipid membranes and membrane deformations are a long-standing area of research in soft matter and biophysics. Computer simulations have complemented analytical and experimental approaches as one of the pillars in the field. However, setting up and using membrane simulations can come with barriers due to the multidisciplinary effort involved and the vast choice of existing simulations models. In this review, we introduce the non-expert reader to coarse-grained membrane simulations at the mesoscale. Firstly, we give a concise overview of the modelling approaches to study fluid membranes, together with guidance to more specialized references. Secondly, we provide a conceptual guide on how to develop mesoscale membrane simulations. Lastly, we construct a hands-on tutorial on how to apply mesoscale membrane simulations, by providing a pedagogical examination of membrane tether pulling, shape and mechanics of membrane tubes, and membrane fluctuations with three different membrane models, and discussing them in terms of their scope and how resource-intensive they are. To ease the reader's venture into the field, we provide a repository with ready-to-run tutorials.},
  author       = {Muñoz Basagoiti, Maitane and Frey, Felix F and Meadowcroft, Billie and Santana de Freitas Amaral, Miguel and Prada, Adam and Šarić, Anđela},
  issn         = {1744-6848},
  journal      = {Soft Matter},
  number       = {40},
  pages        = {7736--7756},
  publisher    = {Royal Society of Chemistry},
  title        = {{A tutorial for mesoscale computer simulations of lipid membranes: Tether pulling, tubulation and fluctuations}},
  doi          = {10.1039/d5sm00148j},
  volume       = {21},
  year         = {2025},
}

@article{20319,
  abstract     = {The time needed by deep convection to bring the atmosphere back to equilibrium is called convective adjustment timescale or simply adjustment timescale, typically denoted by . In the Community Atmospheric Model|Community Atmosphere Model (CAM),  is the convective available potential energy (CAPE) relaxation timescale and is 1 hr, worldwide. Observational evidence suggests that  is generally longer than 1 hr. Further, continental and oceanic convection are different in terms of the vigor of updrafts and can have different longevities. So using  hour worldwide in CAM has two potential caveats. A longer  improves the simulation of the mean climate. However, it does not address the land‐ocean heterogeneity of atmospheric deep convection. We investigate the prescription of two different CAPE relaxation timescales for land ( hr) and ocean ( to 4 hr). It is arguably an extremely crude parameterization of boundary layer control on atmospheric convection. We contrast a suite of 5‐year‐long simulations with two different  for land and ocean to having one  globally. The choice of longer  over ocean is guided by previous studies and inspired by observational pieces of evidence. Nonetheless, to complement our variable  experiments, we perform a simulation with  hr and  hrs. Most importantly, our key findings are immune to the exact values of prescribed  and . The CAM model, with two  values , improves convective‐stratiform rainfall partitioning and the Madden–Julian oscillation propagation characteristics.},
  author       = {GOSWAMI, BIDYUT B and Polesello, Andrea and Muller, Caroline J},
  issn         = {1942-2466},
  journal      = {Journal of Advances in Modeling Earth Systems},
  number       = {9},
  publisher    = {Wiley},
  title        = {{An assessment of representing land‐ocean heterogeneity via CAPE relaxation timescale in the Community Atmospheric Model 6 (CAM6)}},
  doi          = {10.1029/2025ms005035},
  volume       = {17},
  year         = {2025},
}

@article{20320,
  abstract     = {The pseudoforest version of the Strong Nine Dragon Tree Conjecture states that if a graph G has maximum average degree mad(G) = 2 maxH⊆G e(H)/v(H) at most 2(k + d/d+k+1), then it has a decomposition into k + 1 pseudoforests where in one pseudoforest F the components of F have at most d edges. This was proven in 2020 in Grout and Moore (2020). We strengthen this
theorem by showing that we can find such a decomposition where additionally F is acyclic, the diameter of the components of F is at most 2ℓ + 2, where ℓ =⌊d−1/k+1⌋, and at most 2ℓ + 1 if
d ≡ 1 mod (k + 1). Furthermore, for any component K of F and any z ∈ N, we have diam(K) ≤ 2z if e(K) ≥ d − z(k − 1) + 1. We also show that both diameter bounds are best possible as an
extension for both the Strong Nine Dragon Tree Conjecture for pseudoforests and its original conjecture for forests. In fact, they are still optimal even if we only enforce F to have any constant maximum degree, instead of enforcing every component of F to have at most d edges.},
  author       = {Mies, Sebastian and Moore, Benjamin and Smith-Roberge, Evelyne},
  issn         = {0195-6698},
  journal      = {European Journal of Combinatorics},
  number       = {12},
  publisher    = {Elsevier},
  title        = {{Beyond the pseudoforest strong Nine Dragon Tree theorem}},
  doi          = {10.1016/j.ejc.2025.104214},
  volume       = {130},
  year         = {2025},
}

@article{20321,
  abstract     = {Microsecond-to-millisecond motions are instrumental for many biomolecular functions, including enzymatic activity and ligand binding. Bloch-McConnell Relaxation Dispersion (BMRD) Nuclear Magnetic Resonance (NMR) spectroscopy is a key technique for studying these dynamic processes. While BMRD experiments are routinely used to probe protein motions in solution, the experiment is more demanding in the solid state, where dipolar couplings complicate the spin dynamics. It is believed that high deuteration levels are required and sufficient to obtain accurate and quantitative data. Here we show that even under fast magic-angle spinning and high levels of deuteration artifactual “bumps” in 15N R1ρ BMRD profiles are common. The origin of these artifacts is identified as a second-order three-spin Mixed Rotational and Rotary Resonance (MIRROR) recoupling condition. These artifacts are found to be a significant confounding factor for the accurate quantification of microsecond protein dynamics using BMRD in the solid state. We show that the application of low-power continuous wave (CW) decoupling simultaneously with the 15N spin-lock leads to the suppression of these conditions and enables quantitative measurements of microsecond exchange in the solid state. Remarkably, the application of decoupling allows the measurement of accurate BMRD even in fully protonated proteins at 100 kHz MAS, thus extending the scope of μs dynamics measurements in MAS NMR.},
  author       = {Tatman, Benjamin and Sridharan, Vidhyalakshmi and Uttarkabat, Motilal and Jaroniec, Christopher P. and Ernst, Matthias and Rovo, Petra and Schanda, Paul},
  issn         = {1520-5126},
  journal      = {Journal of the American Chemical Society},
  number       = {32},
  pages        = {29315--29326},
  publisher    = {American Chemical Society},
  title        = {{Bumps on the road: The way to clean relaxation dispersion magic-angle spinning NMR}},
  doi          = {10.1021/jacs.5c09057},
  volume       = {147},
  year         = {2025},
}

@article{20322,
  abstract     = {For correlated real symmetric or complex Hermitian random matrices, we prove that the local eigenvalue statistics at any cusp singularity are universal. Since the density of states typically exhibits only square root edge or cubic root cusp singularities, our result completes the proof of the Wigner–Dyson–Mehta universality conjecture in all spectral regimes for a very general class of random matrices. Previously only the bulk and the edge universality were established in this generality (Alt et al. in Ann Probab 48(2):963–1001, 2020), while cusp universality was proven only for Wigner-type matrices with independent entries (Cipolloni et al. in Pure Appl Anal 1:615–707, 2019; Erdős et al. in Commun. Math. Phys. 378:1203–1278, 2018). As our main technical input, we prove an optimal local law at the cusp using the <jats:italic>Zigzag strategy</jats:italic>, a recursive tandem of the characteristic flow method and a Green function comparison argument. Moreover, our proof of the optimal local law holds uniformly in the spectrum, thus we also provide a significantly simplified alternative proof of the local eigenvalue universality in the previously studied bulk (Erdős et al. in Forum Math. Sigma 7:E8, 2019) and edge (Alt et al. in Ann Probab 48(2):963–1001, 2020) regimes.},
  author       = {Erdös, László and Henheik, Sven Joscha and Riabov, Volodymyr},
  issn         = {1432-0916},
  journal      = {Communications in Mathematical Physics},
  number       = {10},
  publisher    = {Springer Nature},
  title        = {{Cusp universality for correlated random matrices}},
  doi          = {10.1007/s00220-025-05417-z},
  volume       = {406},
  year         = {2025},
}

@article{20325,
  abstract     = {Inferring genealogical relationships of wild populations is useful because it gives direct estimates of mating patterns and variance in reproductive success. Inference can be improved by including information about parentage shared between siblings, or by modelling phenotypes or population data related to mating. However, we currently lack a framework to infer parent–offspring relationships, sibships and population parameters in a single analysis. To address this, we here extend a previous method, Fractional Analysis of Paternity and Sibships, to include population data for the case where one parent is known. We illustrate this with the example of pollen dispersal in a natural hybrid zone population of the snapdragon Antirrhinum majus. Pollen dispersal is leptokurtic, with half of mating events occurring within 30 m, but with a long tail of mating events up to 859 m. Using simulations, we find that both sibship and population information substantially improve pedigree reconstruction, and that we can expect to resolve median dispersal distances with high accuracy.},
  author       = {Ellis, Thomas and Field, David and Barton, Nicholas H},
  issn         = {1365-294X},
  journal      = {Molecular Ecology},
  number       = {15},
  publisher    = {Wiley},
  title        = {{Joint estimation of paternity, sibships and pollen dispersal in a snapdragon hybrid zone}},
  doi          = {10.1111/mec.70051},
  volume       = {34},
  year         = {2025},
}

@article{20327,
  abstract     = {Confinement is a prominent phenomenon in condensed-matter and high-energy physics that has recently become the focus of quantum-simulation experiments of lattice gauge theories (LGTs). As such, a theoretical understanding of the effect of confinement on LGT dynamics is not only of fundamental importance but also can lend itself to upcoming experiments. Here we show how confinement in a Z2 LGT can be  avoided by proximity to a resonance between the fermion mass and the electric field strength. Furthermore, we show that this local deconfinement can become global for certain initial conditions, where information transport occurs over the entire chain. In addition, we show how this can lead to strong quantum many-body scarring starting in different initial states. Our findings provide deeper insights into the nature of confinement in Z2 LGTs and can be tested on current and near-term quantum devices.},
  author       = {Desaules, Jean-Yves Marc and Iadecola, Thomas and Halimeh, Jad C.},
  issn         = {2469-9969},
  journal      = {Physical Review B},
  number       = {1},
  publisher    = {American Physical Society},
  title        = {{Mass-assisted local deconfinement in a confined Z2 lattice gauge theory}},
  doi          = {10.1103/mfg2-t6gb},
  volume       = {112},
  year         = {2025},
}

@article{20329,
  abstract     = {Nanocrystals (NCs) of various compositions have made important contributions to science and technology, with their impact recognized by the 2023 Nobel Prize in Chemistry for the discovery and synthesis of semiconductor quantum dots (QDs). Over four decades of research into NCs has led to numerous advancements in diverse fields, such as optoelectronics, catalysis, energy, medicine, and recently, quantum information and computing. The last 10 years since the predecessor perspective “Prospect of Nanoscience with Nanocrystals” was published in ACS Nano have seen NC research continuously evolve, yielding critical advances in fundamental understanding and practical applications. Mechanistic insights into NC formation have translated into precision control over NC size, shape, and composition. Emerging synthesis techniques have broadened the landscape of compounds obtainable in colloidal NC form. Sophistication in surface chemistry, jointly bolstered by theoretical models and experimental findings, has facilitated refined control over NC properties and represents a trusted gateway to enhanced NC stability and processability. The assembly of NCs into superlattices, along with two-dimensional (2D) photolithography and three-dimensional (3D) printing, has expanded their utility in creating materials with tailored properties. Applications of NCs are also flourishing, consolidating progress in fields targeted early on, such as optoelectronics and catalysis, and extending into areas ranging from quantum technology to phase-change memories. In this perspective, we review the extensive progress in research on NCs over the past decade and highlight key areas where future research may bring further breakthroughs.},
  author       = {Ibáñez, Maria and Boehme, Simon C. and Buonsanti, Raffaella and De Roo, Jonathan and Milliron, Delia J. and Ithurria, Sandrine and Rogach, Andrey L. and Cabot, Andreu and Yarema, Maksym and Cossairt, Brandi M. and Reiss, Peter and Talapin, Dmitri V. and Protesescu, Loredana and Hens, Zeger and Infante, Ivan and Bodnarchuk, Maryna I. and Ye, Xingchen and Wang, Yuanyuan and Zhang, Hao and Lhuillier, Emmanuel and Klimov, Victor I. and Utzat, Hendrik and Rainò, Gabriele and Kagan, Cherie R. and Cargnello, Matteo and Son, Jae Sung and Kovalenko, Maksym V.},
  issn         = {1936-086X},
  journal      = {ACS Nano},
  number       = {36},
  pages        = { 31969–32051},
  publisher    = {American Chemical Society},
  title        = {{Prospects of nanoscience with nanocrystals: 2025 edition}},
  doi          = {10.1021/acsnano.5c07838},
  volume       = {19},
  year         = {2025},
}

@article{20330,
  abstract     = {The evolution of sexual dimorphism (the difference in average trait values between females and males, SD), is often thought to be constrained by shared genetic architecture between the sexes. Indeed, it is commonly expected that SD should negatively correlate with the intersex correlation (the genetic correlation between effects of segregating variants in females and males, r fm), either because (1) traits with ancestrally low r fm are less constrained in their ability to respond to sex-specific selection and thus evolve to be more dimorphic, or because (2) sex-specific selection, driving sexual dimorphism evolution, also acts to reduce r fm. Despite the intuitive appeal and prominence of these ideas, their generality and the conditions in which they hold remain unclear. Here, we develop models incorporating sex-specific stabilizing selection, mutation and genetic drift to examine the relationship between r fm and SD. We show that the two commonly-discussed mechanisms with the potential to generate a negative correlation between SD and r fm could just as easily generate a positive association, since the standard line of reasoning hinges on a hidden assumption that sex-specific adaptation more frequently favors increased dimorphism than reduced dimorphism. Our results provide, to our knowledge, the first mechanistic framework for understanding the conditions under which a correlation between r fm and SD may arise and offer a compelling explanation for inconsistent empirical evidence. We also make the intriguing observation that—even when selection between the two sexes is identical—drift generates nonzero SD. We quantify this effect and discuss its significance.},
  author       = {Puixeu Sala, Gemma and Hayward, Laura},
  issn         = {1943-2631},
  journal      = {Genetics},
  number       = {3},
  publisher    = {Oxford University Press},
  title        = {{The relationship between sexual dimorphism and intersex correlation: Do models support intuition?}},
  doi          = {10.1093/genetics/iyaf175},
  volume       = {231},
  year         = {2025},
}

@article{20348,
  abstract     = {Central Asia hosts some of the world’s last relatively healthy mountain glaciers and is heavily dependent on snow and ice melt for downstream water supply, though the causes of this stable glacier state are not known. We combine recent in-situ observations, climate reanalysis and remote sensing data to force a land-surface model to reconstruct glacier changes over the last two decades (1999–2023) and disentangle their causes over a benchmark glacierized catchment in Tajikistan. We show that snowfall and snow depth have been substantially lower since 2018, leading to a decline in glacier health and reduced runoff generation. Remote-sensing observations confirm wider snow depletion across the Northwestern Pamirs, suggesting that a lack of snowfall might be a cause of mass losses regionally. Our results provide an explanation for the recent decline in glacier health in the region, and reinforce the need to better understand the variability of precipitation.},
  author       = {Jouberton, Achille and Shaw, Thomas and Miles, Evan and Kneib, Marin and Fugger, Stefan and Buri, Pascal and Mccarthy, Michael and Kayumov, Abdulhamid and Navruzshoev, Hofiz and Halimov, Ardamehr and Kabutov, Khusrav and Homidov, Farrukh and Pellicciotti, Francesca},
  issn         = {2662-4435},
  journal      = {Communications Earth and Environment},
  publisher    = {Springer Nature},
  title        = {{Snowfall decrease in recent years undermines glacier health and meltwater resources in the Northwestern Pamirs}},
  doi          = {10.1038/s43247-025-02611-8},
  volume       = {6},
  year         = {2025},
}

@article{20349,
  abstract     = {Oogenesis – the formation and development of an oocyte – is fundamental to reproduction and embryonic development. Due to its accessibility to genetic manipulations and the ability to culture and experimentally manipulate oocytes ex vivo, zebrafish has emerged as a powerful vertebrate model system for studying oogenesis. In this review, we provide a comprehensive overview of zebrafish oogenesis, from early germ cell formation to oocyte maturation and fertilization. We discuss recent advances in uncovering the molecular and cellular mechanisms driving this complex process and highlight key knowledge gaps that remain to be addressed.},
  author       = {Hofmann, Laura and Heisenberg, Carl-Philipp J},
  issn         = {1096-3634},
  journal      = {Seminars in Cell and Developmental Biology},
  publisher    = {Elsevier},
  title        = {{Decoding zebrafish oogenesis: From primordial germ cell development to fertilization}},
  doi          = {10.1016/j.semcdb.2025.103650},
  volume       = {175},
  year         = {2025},
}

@article{20350,
  abstract     = {Context. Rotation plays an important role in stellar evolution. However, the mechanisms behind the transport of angular momentum in stars at various stages of their evolution are not well understood. To improve our understanding of these processes, it is necessary to measure and validate the internal rotation profiles of stars across different stages of evolution and mass regimes.
Aims. Our aim is to constrain the internal rotation profile of the 12-M⊙ β Cep pulsator HD 192575 from the observed pulsational multiplets and the asymmetries of their component frequencies.
Methods. We updated the forward asteroseismic modelling of HD 192575 based on new TESS observations. We inverted the rotation profile from the symmetric part of the splittings and computed the multiplet asymmetries due to the Coriolis force and stellar deformation, which we treated perturbatively. We compared the computed asymmetries with the observed asymmetries.
Results. Our new forward asteroseismic modelling is in agreement with previous results but with increased uncertainties, partially due to increased frequency precision, which required us to relax certain constraints. Ambiguity in the mode identification is the main source of the uncertainty, which also affects the inferred rotation profiles. Almost all acceptable rotation profiles occur in the regime below 0.4 d−1 and favour weak radial differential rotation, with a ratio of core to envelope rotation of less than 2. We find that the quality of the match between the observed and theoretically predicted mode asymmetries is strongly dependent on the mode identification and the internal structure of the star.
Conclusions. Our results offer the first detailed rotation inversion for a β Cep pulsator. They show that the rotation profile and the mode asymmetries provide a valuable tool for further constraining the evolutionary properties of HD 192575, and in particular the details of angular momentum transport in massive stars.},
  author       = {Vanlaer, V. and Bowman, D. M. and Burssens, S. and Das, Srijan B and Bugnet, Lisa Annabelle and Mathis, S. and Aerts, C.},
  issn         = {1432-0746},
  journal      = {Astronomy & Astrophysics},
  publisher    = {EDP Sciences},
  title        = {{Interior rotation modelling of the β Cep pulsator HD 192575 including multiplet asymmetries}},
  doi          = {10.1051/0004-6361/202452885},
  volume       = {701},
  year         = {2025},
}

@article{20351,
  abstract     = {Rab GTPases organize intracellular trafficking and provide identity to organelles. Their spatiotemporal activation by guanine nucleotide exchange factors (GEFs) is tightly controlled to ensure fidelity. Our structural and functional comparison of the tri-longin domain RabGEFs Mon1-Ccz1 and Fuzzy-Inturned reveals the molecular basis for their target specificity. Both complexes rely on a conserved sequence motif of their substrate GTPases for the catalytic mechanism, while secondary interactions allow discrimination between targets. We also find that dimeric Mon1-Ccz1 from fungi and the metazoan homologs with the additional third subunit RMC1/Bulli bind membranes through electrostatic interactions via distinct interfaces. Protein-lipid interaction studies and functional characterization in flies reveal an essential function of RMC1/Bulli as mediator of GEF complex membrane recruitment. In the case of Fuzzy-Inturned, reconstitution experiments demonstrate that the BAR (Bin-Amphiphysin-Rvs) domain protein CiBAR1 can support membrane recruitment of the GEF. Collectively, our study demonstrates the molecular basis for the adaptation of TLD-RabGEFs to different cellular functions.},
  author       = {Wilmes, Stephan and Tönjes, Jesse and Drechsler, Maik and Ruf, Anita and Schäfer, Jan Hannes and Lürick, Anna and Januliene, Dovile and Apelt, Steven and Di Iorio, Daniele and Wegner, Seraphine V. and Loose, Martin and Moeller, Arne and Paululat, Achim and Kümmel, Daniel},
  issn         = {2375-2548},
  journal      = {Science Advances},
  number       = {35},
  pages        = {eadx2893},
  publisher    = {AAAS},
  title        = {{Mechanistic adaptation of the metazoan RabGEFs Mon1-Ccz1 and Fuzzy-Inturned}},
  doi          = {10.1126/sciadv.adx2893},
  volume       = {11},
  year         = {2025},
}

@article{20374,
  abstract     = {Pioneer transcription factors (TFs) engage chromatinized DNA motifs. However, it is unclear how the resultant TF-nucleosome complexes are decoded by co-factors. In humans, the TF p53 regulates cell-cycle progression, apoptosis, and the DNA damage response, with a large fraction of p53-bound sites residing in nucleosome-harboring inaccessible chromatin. We examined the interaction of chromatin-bound p53 with co-factors belonging to the ubiquitin proteasome system (UPS). At two distinct motif locations on the nucleosome (super-helical location [SHL]−5.7 and SHL+5.9), the E3 ubiquitin ligase E6-E6AP was unable to bind nucleosome-engaged p53. The deubiquitinase USP7, on the other hand, readily engages nucleosome-bound p53 in vitro and in cells. A corresponding cryo-electron microscopy (cryo-EM) structure shows USP7 engaged with p53 and nucleosomes. Our work illustrates how chromatin imposes a co-factor-selective barrier for p53 interactors, whereby flexibly tethered interaction domains of co-factors and TFs govern compatibility between co-factors, TFs, and chromatin.},
  author       = {Chakraborty, Deyasini and Sandate, Colby R. and Isbel, Luke and Kempf, Georg and Weiss, Joscha and Cavadini, Simone and Kater, Lukas and Seebacher, Jan and Kozicka, Zuzanna and Stoos, Lisa and Grand, Ralph S. and Schübeler, Dirk and Michael, Alicia and Thomä, Nicolas H.},
  issn         = {1097-2765},
  journal      = {Molecular Cell},
  number       = {15},
  pages        = {2919--2936.e12},
  publisher    = {Elsevier},
  title        = {{Nucleosomes specify co-factor access to p53}},
  doi          = {10.1016/j.molcel.2025.06.027},
  volume       = {85},
  year         = {2025},
}

@article{20402,
  abstract     = {The recent classification of the onset of turbulence as a directed percolation (DP) phase transition has been applied to all major shear flows including pipe, channel, Couette and boundary layer flows. A cornerstone of the DP analogy is the memoryless (Poisson) property of turbulent sites. We here show that, for the classic case of channel flow, neither the decay nor the proliferation of turbulent stripes is memoryless. As demonstrated by a standard analysis of the respective survival curves, isolated channel stripes, in the immediate vicinity of the critical point, age. Consequently, the one to one mapping between turbulent stripes and active DP-sites is not fulfilled in this low Reynolds number regime. In addition, the interpretation of turbulence as a chaotic saddle with supertransient properties, the basis of recent theoretical progress, does not apply to individual localized stripes. The discrepancy between channel flow and the transition models established for pipe and Couette flow, illustrates that seemingly minor geometrical differences between flows can give rise to instabilities and growth mechanisms that fundamentally alter the nature of the transition to turbulence.},
  author       = {Vasudevan, Mukund and Paranjape, Chaitanya S and Sitte, Michael Philip and Yalniz, Gökhan and Hof, Björn},
  issn         = {2041-1723},
  journal      = {Nature Communications},
  publisher    = {Springer Nature},
  title        = {{Aging and memory of transitional turbulence}},
  doi          = {10.1038/s41467-025-63044-7},
  volume       = {16},
  year         = {2025},
}

@article{20404,
  abstract     = {Collagens are fundamental components of extracellular matrices, requiring precise intracellular post-translational modifications for proper function. Among the modifications, prolyl 4-hydroxylation is critical to stabilise the collagen triple helix. In humans, this reaction is mediated by collagen prolyl 4-hydroxylases (P4Hs). While humans possess three genes encoding these enzymes (P4H⍺s), Drosophila melanogaster harbour at least 26 candidates for collagen P4H⍺s despite its simple genome, and it is poorly understood which of them are actually working on collagen in the fly. In this study, we addressed this question by carrying out thorough bioinformatic and biochemical analyses. We demonstrate that among the 26 potential collagen P4H⍺s, PH4⍺EFB shares the highest homology with vertebrate collagen P4H⍺s. Furthermore, while collagen P4Hs and their substrates must exist in the same cells, our transcriptomic analyses at the tissue and single cell levels showed a global co-expression of PH4⍺EFB but not the other P4H⍺-related genes with the collagen IV genes. Moreover, expression of PH4⍺EFB during embryogenesis was found to precede that of collagen IV, presumably enabling efficient collagen modification by PH4⍺EFB. Finally, biochemical assays confirm that PH4⍺EFB binds collagen, supporting its direct role in collagen IV modification. Collectively, we identify PH4⍺EFB as the primary and potentially constitutive prolyl 4-hydroxylase responsible for collagen IV biosynthesis in Drosophila. Our findings highlight the remarkably simple nature of Drosophila collagen IV biosynthesis, which may serve as a blueprint for defining the minimal requirements for collagen engineering.},
  author       = {Ishikawa, Yoshihiro and Toups, Melissa A and Elkrewi, Marwan N and Zajac, Allison L. and Horne-Badovinac, Sally and Matsubayashi, Yutaka},
  issn         = {1569-1802},
  journal      = {Matrix Biology},
  number       = {11},
  pages        = {101--113},
  publisher    = {Springer Nature},
  title        = {{Evidence for the major role of PH4⍺EFB in the prolyl 4-hydroxylation of Drosophila collagen IV}},
  doi          = {10.1016/j.matbio.2025.09.002},
  volume       = {141},
  year         = {2025},
}

@article{20405,
  abstract     = {Dielectric breakdown of physical vacuum (Schwinger effect) is the textbook demonstration of compatibility of Relativity and Quantum theory. Although observing this effect is still practically unachievable, its analogue generalizations have been shown to be more readily attainable. This paper demonstrates that a gapped Dirac semiconductor, methylammonium lead-bromide perovskite (MAPbBr3), exhibits analogue dynamic Schwinger effect. Tunneling ionization under deep subgap mid-infrared irradiation leads to intense photoluminescence in the visible range, in full agreement with quasi-adiabatic theory. In addition to revealing a gapped extended system suitable for studying the analogue Schwinger effect, this observation holds great potential for nonperturbative field sensing, i.e., sensing electric fields through nonperturbative light-matter interactions. First, this paper illustrates this by measuring the local deviation from the nominally cubic phase of a perovskite single crystal, which can be interpreted in terms of frozen-in fields. Next, it is shown that analogue dynamic Schwinger effect can be used for nonperturbative amplification of nonparametric upconversion process in perovskites driven simultaneously by multiple optical fields. This discovery demonstrates the potential for material response beyond perturbation theory in the tunneling regime, offering extremely sensitive light detection and amplification across an ultrabroad spectral range not accessible by conventional devices.},
  author       = {Lorenc, Dusan and Volosniev, Artem and Zhumekenov, Ayan A. and Lee, Seungho and Ibáñez, Maria and Bakr, Osman M. and Lemeshko, Mikhail and Alpichshev, Zhanybek},
  issn         = {2330-4022},
  journal      = {ACS Photonics},
  number       = {9},
  pages        = {5220--5230},
  publisher    = {American Chemical Society},
  title        = {{Observation of analogue dynamic Schwinger effect and non-perturbative light sensing in lead halide perovskites}},
  doi          = {10.1021/acsphotonics.5c01360},
  volume       = {12},
  year         = {2025},
}