@misc{20547, abstract = {DebdaB is a database of measured and reported physical properties and thickness of supraglacial debris that is openly available and open to community submissions. The majority of the database (90%) is compiled from 172 sources in the literature, and the remaining 10% has not been published before. DebDaB contains 8,286 data entries for supraglacial debris thickness, of which 1,852 entries also include sub-debris ablation rates, 167 data entries of thermal conductivity of debris, 157 of aerodynamic surface roughness length, 77 of debris albedo, 56 of debris emissivity and 37 of debris porosity. The data are distributed over 83 glaciers in 13 regions in the Global Terrestrial Network for Glaciers. }, author = {Groeneveld, Lars and Fontrodona-Bach, Adrià and Miles, Evan and McCarthy, Michael and Melo Velasco, Juan Vicente and Shaw, Thomas and Pellicciotti, Francesca and Bauder, Andreas and Buri, Pascal and Kneib, Marin and Kumar, Amit and Mishra, Aditya and Petersen, lene and Renner, Roman and Schmid, Sandro}, publisher = {Zenodo}, title = {{DebDaB: A database of supraglacial debris thickness and physical properties}}, doi = {10.5281/ZENODO.14224835}, year = {2025}, } @phdthesis{20575, abstract = {This thesis deals with eigenvalue and eigenvector universality results for random matrix ensembles equipped with non-trivial spatial structure. We consider both mean-field models with a general variance profile (Wigner-type matrices) and correlation structure (correlated matrices) among the entries, as well as non-mean-field random band matrices with bandwidth W >> N^(1/2). To extract the universal properties of random matrix spectra and eigenvectors, we obtain concentration estimates for their resolvent, the local laws, which generalize the celebrated Wigner semicircle law for a broad class of random matrices to much finer spectral scales. The local laws hold for both a single resolvent as well as for products of multiple resolvents, known as resolvent chains, and express the remarkable approximately-deterministic behavior of these objects down to the microscopic scale. Our primary tool for establishing the local laws is the dynamical Zigzag strategy, which we develop in the setting of spatially-inhomogeneous random matrices. Our proof method systematically addresses the challenges arising from non-trivial spatial structures and is robust to all types of singularities in the spectrum, as we demonstrate in the correlated setting. Furthermore, we incorporate the analysis of the deterministic resolvent chain approximations into the dynamical framework of the Zigzag strategy, synthesizing a unified toolkit for establishing multi-resolvent local laws. Using these methods, we prove complete eigenvector delocalization, the Eigenstate Thermalization Hypothesis, and Wigner-Dyson universality in the bulk for random band matrices down to the optimal bandwidth W >> N^(1/2). For mean-field ensembles, we establish universality of local eigenvalue statistics at the cups for random matrices with correlated entries, and the Eigenstate Thermalization Hypothesis for Wigner-type matrices in the bulk of the spectrum. Finally, this thesis also contains other applications of the multi-resolvent local laws to spatially-inhomogeneous random matrices, obtained prior to the development of the Zigzag strategy. In particular, we provide a complete analysis of mesoscopic linear-eigenvalue statistics of Wigner-type matrices in all spectral regimes, including the novel cusps, and rigorously establish the prethermalization phenomenon for deformed Wigner matrices. The main body of this thesis consists of seven research papers (listed on page xi), each presented in a separate chapter with its own introduction and all relevant context, suitable to be read independently. We ask the reader’s indulgence for the repetitions in the historical overviews and other minor redundancies that remain among the chapters as a result. The overall Introduction, preceding the chapters, provides a condensed, informal summary of the main ideas and concepts at the core of these works. }, author = {Riabov, Volodymyr}, isbn = {978-3-99078-064-0}, issn = {2663-337X}, pages = {436}, publisher = {Institute of Science and Technology Austria}, title = {{Universality in random matrices with spatial structure}}, doi = {10.15479/AT-ISTA-20575}, year = {2025}, } @unpublished{20576, abstract = {We prove that a very general class of $N\times N$ Hermitian random band matrices is in the delocalized phase when the band width $W$ exceeds the critical threshold, $W\gg \sqrt{N}$. In this regime, we show that, in the bulk spectrum, the eigenfunctions are fully delocalized, the eigenvalues follow the universal Wigner-Dyson statistics, and quantum unique ergodicity holds for general diagonal observables with an optimal convergence rate. Our results are valid for general variance profiles, arbitrary single entry distributions, in both real-symmetric and complex-Hermitian symmetry classes. In particular, our work substantially generalizes the recent breakthrough result of Yau and Yin [arXiv:2501.01718], obtained for a specific complex Hermitian Gaussian block band matrix. The main technical input is the optimal multi-resolvent local laws -- both in the averaged and fully isotropic form. We also generalize the $\sqrtη$-rule from [arXiv:2012.13215] to exploit the additional effect of traceless observables. Our analysis is based on the zigzag strategy, complemented with a new global-scale estimate derived using the static version of the master inequalities, while the zig-step and the a priori estimates on the deterministic approximations are proven dynamically.}, author = {Erdös, László and Riabov, Volodymyr}, booktitle = {arXiv}, title = {{The zigzag strategy for random band matrices}}, doi = {10.48550/ARXIV.2506.06441}, year = {2025}, } @unpublished{20580, abstract = {This paper explores the geometry of the space of codimension-2 submanifolds. We implicitly represent these submanifolds by a class of complex-valued functions. This reveals a prequantum bundle structure over the space of submanifolds, equipped with the well-known Marsden-Weinstein symplectic structure. This bundle allows a new physical interpretation of the Marsden-Weinstein structure as the curvature of a connection form, which measures the average of volumes swept by the deformation of the S^1-family of hypersurfaces, defined as the phases of a complex function implicitly representing a submanifold.}, author = {Chern, Albert and Ishida, Sadashige}, booktitle = {arXiv}, title = {{Implicit representations of codimension-2 submanifolds and their prequantum structure}}, doi = {10.48550/ARXIV.2507.11727}, year = {2025}, } @article{20586, abstract = {We present the discovery of deep, irregular, periodic transits toward the white dwarf ZTF J1944+4557 using follow-up time-series photometry and spectroscopy from Palomar, Keck, McDonald, Perkins, and Lowell observatories. We find a predominant period of 4.9704 hr, consistent with an orbit near the Roche limit of the white dwarf, with individual dips over 30% deep and lasting between 15 and 40 minutes. Similar to the first known white dwarf with transiting debris, WD 1145+017, the transit events are well-defined with prominent out-of-transit phases where the white dwarf appears unobscured. Spectroscopy concurrent with transit photometry reveals that the average Ca K equivalent width remains constant in and out of transit. The broadening observed in several absorption features cannot be reproduced by synthetic photospheric models, suggesting the presence of circumstellar gas. Simultaneous g + r- and g + i-band light curves from the CHIMERA instrument reveal no color dependence to the transit depths, requiring transiting dust grains to have sizes s ≳ 0.2 μm. The transit morphologies appear to be constantly changing at a rate faster than the orbital period. Overall transit activity varies in the system, with transit features completely disappearing during the seven months between our 2023 and 2024 observing seasons and then reappearing in 2025 March, still repeating at 4.9704 hr. Our observations of the complete cessation and resumption of transit activity provide a novel laboratory for constraining the evolution of disrupted debris and processes like disk exhaustion and replenishment timescales at white dwarfs.}, author = {Guidry, Joseph A. and Vanderbosch, Zachary P. and Hermes, J. J. and Veras, Dimitri and Hollands, Mark A. and Bhattacharjee, Soumyadeep and Caiazzo, Ilaria and El-Badry, Kareem and Kao, Malia L. and Ould Rouis, Lou Baya and Rodriguez, Antonio C. and Van Roestel, Jan}, issn = {1538-4357}, journal = {The Astrophysical Journal}, number = {2}, publisher = {IOP Publishing}, title = {{Transiting planetary debris near the Roche limit of a white dwarf on a 4.97 hr orbit—and its vanishing}}, doi = {10.3847/1538-4357/adfecb}, volume = {992}, year = {2025}, } @inproceedings{20587, abstract = {The blocks in the Bitcoin blockchain "record" the amount of work W that went into creating them through proofs of work. When honest parties control a majority of the work, consensus is achieved by picking the chain with the highest recorded weight. Resources other than work have been considered to secure such longest-chain blockchains. In Chia, blocks record the amount of disk-space S (via a proof of space) and sequential computational steps V (through a VDF). In this paper, we ask what weight functions Γ(S,V,W) (that assign a weight to a block as a function of the recorded space, speed, and work) are secure in the sense that whenever the weight of the resources controlled by honest parties is larger than the weight of adversarial parties, the blockchain is secure against private double-spending attacks. We completely classify such functions in an idealized "continuous" model: Γ(S,V,W) is secure against private double-spending attacks if and only if it is homogeneous of degree one in the "timed" resources V and W, i.e., αΓ(S,V,W) = Γ(S,α V, α W). This includes the Bitcoin rule Γ(S,V,W) = W and the Chia rule Γ(S,V,W) = S ⋅ V. In a more realistic model where blocks are created at discrete time-points, one additionally needs some mild assumptions on the dependency on S (basically, the weight should not grow too much if S is slightly increased, say linear as in Chia). Our classification is more general and allows various instantiations of the same resource. It provides a powerful tool for designing new longest-chain blockchains. E.g., consider combining different PoWs to counter centralization, say the Bitcoin PoW W₁ and a memory-hard PoW W₂. Previous work suggested to use W₁+W₂ as weight. Our results show that using e.g., √{W₁}⋅ √{W₂} or min{W₁,W₂} are also secure, and we argue that in practice these are much better choices.}, author = {Baig, Mirza Ahad and Günther, Christoph Ullrich and Pietrzak, Krzysztof Z}, booktitle = {7th Conference on Advances in Financial Technologies}, isbn = {9783959774000}, issn = {1868-8969}, location = {Pittsburgh, PA, United States}, publisher = {Schloss Dagstuhl - Leibniz-Zentrum für Informatik}, title = {{Nakamoto consensus from multiple resources}}, doi = {10.4230/LIPIcs.AFT.2025.16}, volume = {354}, year = {2025}, } @article{20588, abstract = {In this second paper on our variability survey of central stars of planetary nebulae (CSPNe) using the Zwicky Transient Facility (ZTF), we report 11 long-timescale variables with variability timescales ranging from months to years. We also present preliminary analyses based on spectroscopic and/or photometric follow-up observations for six of them. Among them is NGC 6833, which shows a 980 days periodic variability with strange characteristics: “triangle-shaped” brightening in r, i, and WISE bands but almost coincidental shallow dips in the g-band. The most plausible explanation is a wide binary with the photometric period being the orbital period. Long-period near-sinusoidal variability was detected in two other systems, NGC 6905 and Kn 26, with periods of 700 days and 230 days, respectively, making them additional wide-binary candidates. The latter also shows a short period at 1.18 hr. We then present CTSS 2 and K 3-5, which show brightening and significant reddening over the whole ZTF baseline. A stellar model fit to the optical spectrum of CTSS 2 reveals it to be one of the youngest post-AGB CSPNe known. Both show high-density emission-line cores. We propose these to be late-thermal-pulse candidates, currently evolving towards the AGB phase. We then present recent HST/COS ultraviolet spectroscopy of the known wide-binary candidate LoTr 1, showing that the hot star is a spectroscopic twin of the extremely hot white dwarf in UCAC2 46706450. Similar to this object, LoTr 1 also has a fast rotating wide subgiant companion. We suggest that the long photometric period of 11 yr is the binary orbital period. Finally, we briefly discuss the ZTF light curves of the remaining variables, namely Tan 2, K 3-20, WHTZ 3, Kn J1857+3931, and IPHAS J1927+0814. With these examples, we present the effectiveness of the von Neumann statistics and Pearson Skew-based metric space in searching for long-timescale variables.}, author = {Bhattacharjee, Soumyadeep and Reindl, Nicole and Bond, Howard E. and Werner, Klaus and Zeimann, Gregory R. and Jones, David and El-Badry, Kareem and Mackensen, Nina and Chornay, Nicholas and Kulkarni, S. R. and Caiazzo, Ilaria and Van Roestel, Jan and Rodriguez, Antonio C. and Prince, Thomas A. and Rusholme, Ben and Laher, Russ R. and Smith, Roger}, issn = {1538-3873}, journal = {Publications of the Astronomical Society of the Pacific}, number = {10}, publisher = {IOP Publishing}, title = {{Variability of central stars of planetary nebulae with the Zwicky Transient Facility. II. Long-timescale variables including wide binary and late thermal pulse candidates}}, doi = {10.1088/1538-3873/ae051e}, volume = {137}, year = {2025}, } @article{20589, abstract = {Context. This paper investigates the star formation histories (SFHs) of a sample of massive galaxies (M⋆ ≥ 1010 M⊙) in the redshift range 1 < z < 4.5. Methods. We analyzed spectro-photometric data, combining broadband photometry from HST and JWST with low-resolution grism spectroscopy from JWST/NIRISS, obtained as part of the MIRI Deep Imaging Survey program. SFHs were derived through spectral energy distribution fitting using two independent codes, BAGPIPES and synthesizer, under various SFH assumptions. This approach enables a comprehensive assessment of the biases introduced by different modeling choices. Results. The inclusion of NIRISS spectroscopy, even with its low resolution, significantly improves constraints on key physical parameters, such as the mass-weighted stellar age (tM) and formation redshift (zform), by narrowing their posterior distributions. The massive galaxies in our sample exhibit rapid stellar mass assembly, forming 50% of their mass between 3 ≤ z ≤ 9. The highest inferred formation redshifts are compatible with elevated star formation efficiencies (ϵ) at early epochs. Nonparametric SFHs generally imply an earlier and slower mass assembly compared to parametric forms, highlighting the sensitivity of inferred formation timescales to the chosen SFH model–particularly for galaxies at z < 2. We find that quiescent galaxies are, on average, older (tM ∼ 1.1 Gyr) and assembled more rapidly at earlier times than their star-forming counterparts. These findings support the “downsizing” scenario, in which more massive and passive systems form earlier and more efficiently.}, author = {Annunziatella, M. and P’Erez-Gonz’Alez, P. G. and Álvarez-Márquez, J. and Costantin, L. and Iani, Edoardo and Labiano, Unknown and Rinaldi, P. and Boogaard, L. and Meyer, R. A. and Östlin, G. and Colina, L. and Melinder, J. and Jermann, I. and Gillman, S. and Langeroodi, D. and Hjorth, J. and Alonso-Herrero, A. and Eckart, A. and Walter, F. and Van Der Werf, P. P. and Bik, A. and Peißker, F. and Caputi, K. I. and García-Marín, M. and Wright, G. and Greve, T. R.}, issn = {1432-0746}, journal = {Astronomy & Astrophysics}, publisher = {EDP Sciences}, title = {{MIDIS: Unveiling the star formation history in massive galaxies at 1 < z < 4.5 with spectro-photometric analysis}}, doi = {10.1051/0004-6361/202453298}, volume = {702}, year = {2025}, } @inproceedings{20592, abstract = {Filtering-based probabilistic numerical solvers for ordinary differential equations (ODEs), also known as ODE filters, have been established as efficient methods for quantifying numerical uncertainty in the solution of ODEs. In practical applications, however, the underlying dynamical system often contains uncertain parameters, requiring the propagation of this model uncertainty to the ODE solution. In this paper, we demonstrate that ODE filters, despite their probabilistic nature, do not automatically solve this uncertainty propagation problem. To address this limitation, we present a novel approach that combines ODE filters with numerical quadrature to properly marginalize over uncertain parameters, while accounting for both parameter uncertainty and numerical solver uncertainty. Experiments across multiple dynamical systems demonstrate that the resulting uncertainty estimates closely match reference solutions. Notably, we show how the numerical uncertainty from the ODE solver can help prevent overconfidence in the propagated uncertainty estimates, especially when using larger step sizes. Our results illustrate that probabilistic numerical methods can effectively quantify both numerical and parametric uncertainty in dynamical systems. }, author = {Yao, Dingling and Tronarp, Filip and Bosch, Nathanael}, booktitle = {Proceedings of the 1st International Conference on Probabilistic Numerics}, issn = {2640-3498}, location = {Sophia Antipolis, France}, publisher = {ML Research Press}, title = {{Propagating model uncertainty through filtering-based probabilistic numerical ODE solvers}}, volume = {271}, year = {2025}, } @article{20593, abstract = {“Quasi-solid-state” conversion mechanisms using sparingly solvating electrolytes (SPSEs) bridge the gap between traditional solid–liquid–solid and solid-state sulfur conversion in lithium–sulfur (Li–S) batteries. Although these terms are commonly used, their precise distinctions and impacts on key performance metrics, such as rate capability, energy density, and capacity fading, remain poorly understood. In this work, we employ operando small- and wide-angle X-ray scattering alongside cryogenic transmission electron microscopy (cryo-TEM) to compare Li–S batteries in sparingly solvating and solvating ether-based electrolytes. We find that, unlike solvating electrolytes, SPSEs lead to an extended presence of lithium sulfide during cycling, coexisting with sulfur at a 50% state of charge and beyond. In the charged state, solid sulfur is present in its amorphous form inside the carbon black nanopores. These findings indicate that the limited solubility confines polysulfides in regions near the carbon surface, where these polysulfides enable conversion between the coexisting solid discharge and charge product.}, author = {Dutta, Pronoy and Von Mentlen, Jean Marc and Mondal, Soumyadip and Kostoglou, Nikolaos and Wilts, Bodo D. and Freunberger, Stefan Alexander and Zickler, Gregor A. and Prehal, Christian}, issn = {2380-8195}, journal = {ACS Energy Letters}, pages = {5722--5732}, publisher = {American Chemical Society}, title = {{Bridging solution and solid-state mechanism: Confined quasi-solid-state conversion in Li–S batteries}}, doi = {10.1021/acsenergylett.5c02093}, volume = {10}, year = {2025}, } @article{20594, abstract = {(Scanning) transmission electron microscopy ((S)TEM) has significantly advanced materials science but faces challenges in correlating precise atomic structure information with the functional properties of devices due to its time-intensive nature. To address this, an analytical workflow is introduced for the holistic characterization, modelling, and simulation of device heterostructures. This workflow automates the experimental (S)TEM data analysis, providing an in-depth characterization of crystallographic information, 3D orientation, elemental composition, and strain distribution. It reduces a process that typically takes days for a trained human into an automatic routine solved in minutes. Utilizing a physics-guided artificial intelligence model, it generates representative descriptions of materials and samples. The workflow culminates in creating digital twins of systems limited with at least one axis of translational invariance –3D finite element and atomic models of millions of atoms–enabling simulations that provide crucial insights into device behavior in practical applications. Demonstrated with SiGe planar heterostructures for scalable spin qubits, the workflow links digital twins to theoretical properties, revealing how atomic structure impacts materials and functional properties such as spatially-resolved phononic or electronic characteristics, or (inverse) spin orbit lengths. The versatility of the workflow is demonstrated through its application to a wide array of materials systems, device configurations, and sample morphologies.}, author = {Botifoll, Marc and Pinto-Huguet, Ivan and Rotunno, Enzo and Galvani, Thomas and Coll, Catalina and Kavkani, Payam Habibzadeh and Spadaro, Maria Chiara and Niquet, Yann Michel and Eriksen, Martin Børstad and Martí-Sánchez, Sara and Katsaros, Georgios and Scappucci, Giordano and Krogstrup, Peter and Isella, Giovanni and Cabot, Andreu and Merino, Gonzalo and Ordejón, Pablo and Roche, Stephan and Grillo, Vincenzo and Arbiol, Jordi}, issn = {1521-4095}, journal = {Advanced Materials}, publisher = {Wiley}, title = {{Artificial intelligence-assisted workflow for transmission electron microscopy: From data analysis automation to materials knowledge unveiling}}, doi = {10.1002/adma.202506785}, year = {2025}, } @article{20604, abstract = {Entry into and exit from cellular quiescence require dynamic adjustments in nutrient acquisition, yet the mechanisms by which quiescent cells downregulate amino acid (AA) transport remain poorly understood. Here we show that cells entering quiescence selectively target plasma membrane-resident amino acid transporters for endocytosis and lysosomal degradation. This process matches amino acid uptake with reduced translational demand and promotes survival during extended periods of quiescence. Mechanistically, we identify the α-arrestin TXNIP as a key regulator of this metabolic adaptation, since it mediates the endocytosis of the SLC7A5-SLC3A2 (LAT1-4F2hc) AA transporter complex in response to reduced AKT signaling. To promote transporter ubiquitination, TXNIP interacts with NEDD4L and other HECT-type ubiquitin ligases. Loss of TXNIP disrupts this regulation, resulting in dysregulated amino acid uptake, sustained mTORC1 signaling, and ultimately cell death under prolonged quiescence. The characterization of a novel TXNIP loss-of-function variant in a patient with a severe metabolic disease further supports its role in nutrient homeostasis and human health. Together, these findings highlight TXNIP’s central role in controlling nutrient acquisition and metabolic plasticity with implications for quiescence biology and diseases.}, author = {Kahlhofer, Jennifer and Marchet, Nikolas and Zubak, Kristian and Seifert, Brigitta and Hotze, Madlen and Egger-Hörschinger, Anna-Sophia and Kucej, Lucija and Manzl, Claudia and Weyer, Yannick and Weys, Sabine and Offterdinger, Martin and Herzog, Sebastian and Reiterer, Veronika and Volani, Chiara and Kwiatkowski, Marcel and Wortmann, Saskia B and Nemati, Siamak and Mayr, Johannes A and Zschocke, Johannes and Radlinger, Bernhard and Thedieck, Kathrin and Kremser, Leopold and Sarg, Bettina and Huber, Lukas A and Farhan, Hesso and de Araujo, Mariana E G and Kaser, Susanne and Scholl-Bürgi, Sabine and Karall, Daniela and Teis, David}, issn = {1460-2075}, journal = {The EMBO Journal}, pages = {7119--7153}, publisher = {Embo Press}, title = {{TXNIP mediates LAT1/SLC7A5 endocytosis to limit amino acid uptake in cells entering quiescence}}, doi = {10.1038/s44318-025-00608-9}, volume = {44}, year = {2025}, } @inproceedings{20610, abstract = {Markov decision processes (MDPs) are a fundamental model of decision making which exhibit non-deterministic choice as well as probabilistic uncertainty. Traditionally, verification assumes exact knowledge of the probabilities that govern the behaviour of an MDP. However, this assumption often is unrealistic, e.g. when modelling cyber-physical systems or biological processes. There, we can employ statistical model checking (SMC) to obtain an estimate of the MDP’s value (e.g. the maximal probability of reaching a goal state) that is close to the true value with high confidence (probably approximately correct). Model-based SMC algorithms sample the MDP and build a model of it by estimating all transition probabilities, essentially for every transition answering the question: “What are the odds?” However, so far the statistical methods employed by state-of-the-art SMC verification algorithms are quite naive or even compromise the correctness guarantees. Our first contribution is to survey, categorize, and analyse statistical methods, identifying those few that are most efficient and that provide suitable guarantees for the verification setting. Secondly, we propose improvements that exploit structural knowledge of the MDP. Both contributions generalize to many types of problem statements as they are largely independent of the setting. Moreover, our experimental evaluation shows that they lead to significant gains, reducing the number of samples that an SMC algorithm has to collect by up to two orders of magnitude.}, author = {Meggendorfer, Tobias and Weininger, Maximilian and Wienhöft, Patrick}, booktitle = {Second International Joint Conference on QEST+FORMATS}, isbn = {9783032057914}, issn = {1611-3349}, location = {Aarhus, Denmark}, pages = {195--218}, publisher = {Springer Nature}, title = {{What are the odds? Improving statistical model checking of Markov decision processes}}, doi = {10.1007/978-3-032-05792-1_11}, volume = {16143}, year = {2025}, } @article{20628, abstract = {The realistic simulation of sand, soil, powders, rubble piles, and large collections of rigid bodies is a common and important problem in the fields of computer graphics, computational physics, and engineering. Direct simulation of these individual bodies quickly becomes expensive, so we often approximate the entire group as a continuum material that can be more easily computed using tools for solving partial differential equations, like the material point method (MPM). In this paper, we present a method for automatically extracting continuum material properties from a collection of rigid bodies. We use numerical homogenization with periodic boundary conditions to simulate an effectively infinite number of rigid bodies in contact. We then record the effective stress-strain relationships from these simulations and convert them into elastic properties and yield criteria for the continuum simulations. Our experiments validate existing theoretical models like the Mohr-Coulomb yield surface by extracting material behaviors from a collection of spheres in contact. We further generalize these existing models to more exotic materials derived from diverse and non-convex shapes. We observe complicated jamming behaviors from non-convex grains, and we introduce a new material model for materials with extremely high levels of internal friction and cohesion. We simulate these new continuum models using MPM with an improved return mapping technique. The end result is a complete system for turning an input rigid body simulation into an efficient continuum simulation with the same effective mechanical properties.}, author = {Chen, Yi-Lu and Ly, Mickaël and Wojtan, Christopher J}, issn = {1557-7368}, journal = {ACM Transactions on Graphics}, location = {Hong Kong, China}, number = {6}, publisher = {Association for Computing Machinery}, title = {{Numerical homogenization of sand from grain-level simulations}}, doi = {10.1145/3763344}, volume = {44}, year = {2025}, } @article{20635, abstract = {Plants have evolved sophisticated mechanisms to adapt to environmental changes, with root gravitropism playing a pivotal role in nutrient and water acquisition. Our study reveals that SnRK2 kinases (SnRK2.2 and SnRK2.3) are critical regulators of root gravitropism through their direct phosphorylation of the auxin transporter PIN2 at S259. We demonstrate that SnRK2s-mediated phosphorylation modulates both the polar localization and transport activity of PIN2. Importantly, SnRK2s function antagonistically to the AGCVIII kinase PID, which phosphorylates PIN2 at a distinct site (S258), establishing a regulatory balance essential for adaptive root growth. Structural modeling and phosphorylation assays further suggest that SnRK2s-mediated phosphorylation at S259 sterically hinders access of PID to S258, providing a mechanistic basis for their antagonistic relationship. These findings uncover a novel regulatory mechanism, by which plants fine-tune root developmental programs to adapt to environmental stimuli, highlighting the evolutionary significance of multilayered kinase-mediated regulation in plant adaptation.}, author = {Sheng, F and Gao, Y and Wang, Y and Li, Y and Zhang, JA and Zhang, Z and Qin, X and Zhang, S and Song, W and Li, J and Guo, Y and Friml, Jiří and Gong, Z and Zhang, Q and Zhang, J}, issn = {1091-6490}, journal = {Proceedings of the National Academy of Sciences}, number = {39}, pages = {e2512274122}, publisher = {National Academy of Sciences}, title = {{Antagonistic SnRK2 and PID kinases' action on auxin transport-mediated root gravitropism}}, doi = {10.1073/pnas.2512274122}, volume = {122}, year = {2025}, } @article{20649, abstract = {Ionized proximity zones around luminous quasars provide a unique laboratory to characterize the Lyα emission lines from z > 6 galaxies without significant attenuation from the intergalactic medium (IGM). However, Lyα line measurements for galaxies within high-redshift quasars’ proximity zones have been rare so far. Here we present deep spectroscopic observations obtained with the NIRSpec/Micro-Shutter Assembly (MSA) instrument on the James Webb Space Telescope of galaxies in two z > 6 quasar fields. We measure the Lyα line fluxes for 50 galaxies at 6 < z < 7 with UV absolute magnitude M UV < −19 (median M UV = −19.97), among which 15 are located near the luminous quasars, i.e., within Δv < 2500 km s−1. We find that galaxies near the quasars show significant flux blueward of the systemic Lyα wavelength, and have higher Lyα equivalent width compared to galaxies at similar redshifts that are not located within the quasars’ environment. Our result indicates little or no redshift evolution for the Lyα emitter fraction from z ∼ 6.4 to z ∼ 5. Leveraging the low IGM opacity in the quasars’ vicinity, we evaluate the Lyα escape fraction (f esc Ly α) of high-redshift galaxies. Our analysis suggests that galaxies at 〈z〉 ≈ 6.4 have an average f esc Ly α = 0.14 ± 0.04. This value is consistent with reionization models where the Lyman continuum escape fraction is low ( fescLyC ≲ 0.1 ) for luminous galaxies, and where the most luminous galaxies have only a minor contribution to the total ionizing photon budget. © 2025. The Author(s). Published by the American Astronomical Society.}, author = {Yue, Minghao and Eilers, Anna Christina and Matthee, Jorryt J and Naidu, Rohan P. and Bordoloi, Rongmon and Davies, Frederick B. and Hennawi, Joseph F. and Kashino, Daichi and Mackenzie, Ruari and Simcoe, Robert A.}, issn = {2041-8213}, journal = {The Astrophysical Journal Letters}, number = {1}, publisher = {IOP Publishing}, title = {{Escape fractions from unattenuated Lyα emitters around luminous z > 6 quasars}}, doi = {10.3847/2041-8213/ae0e0e}, volume = {993}, year = {2025}, } @article{20651, abstract = {The origin of merging binary black holes detected through gravitational waves remains a fundamental question in astrophysics. While stellar evolution imposes an upper mass limit of ∼50⁢𝑀⊙ for black holes, some observed mergers—most notably GW190521—involve significantly more massive components, suggesting alternative formation channels. Here we investigate the maximum masses attainable by black hole mergers within active galactic nucleus (AGN) disks. Using a comprehensive semianalytic model incorporating 27 binary and environmental parameters, we explore the role of AGN disk conditions in shaping the upper end of the black hole mass spectrum. We find that an AGN disk lifetime is the dominant factor, with high-mass mergers (≳200⁢𝑀⊙) only possible if disks persist for ≳40  Myr. The joint electromagnetic observation of an AGN-assisted merger could therefore lead to a direct measurement of the age of an AGN disk.}, author = {Xue, Ling Qin and Tagawa, Hiromichi and Haiman, Zoltán and Bartos, Imre}, issn = {2470-0029}, journal = {Physical Review D}, number = {6}, publisher = {American Physical Society}, title = {{What determines the maximum mass of AGN-assisted black hole mergers?}}, doi = {10.1103/5m1n-qh9v}, volume = {112}, year = {2025}, } @inproceedings{20658, abstract = {The medial axis of a smoothly embedded surface in R^3 consists of all points for which the Euclidean distance function on the surface has at least two global minima. We generalize this notion to the mid-sphere axis, which consists of all points for which the Euclidean distance function has two interchanging saddles that swap their partners in the pairing by persistent homology. It offers a discrete-algebraic multi-scale approach to computing ridge-like structures on the surface. As a proof of concept, an algorithm that computes stair-case approximations of the mid-sphere axis is provided.}, author = {Edelsbrunner, Herbert and Stephenson, Elizabeth R and Thoresen, Martin H}, booktitle = {4th International Joint Conference on Discrete Geometry and Mathematical Morphology}, isbn = {9783032095435}, issn = {1611-3349}, location = {Groningen, The Netherlands}, pages = {133--147}, publisher = {Springer Nature}, title = {{The mid-sphere cousin of the medial axis transform}}, doi = {10.1007/978-3-032-09544-2_10}, volume = {16296}, year = {2025}, } @article{20659, abstract = {Metabotropic GABA (GABAB) receptors have modulatory functions on neuronal excitability and neurotransmitter release. To fulfil these functions, GABAB receptors form macromolecular signaling complexes with G proteins, effectors, and other associated proteins. Here we investigated the postnatal development of GABAB receptors (GABAB1 and GABAB2 subunits) in mouse brain, focusing on potential similarities in the spatial and temporal expression pattern of their associated proteins CaV2.1, Gαo, Gβ5, and RGS7, using histoblots, immunofluorescence, and immunoelectron microscopic techniques. At all ages analyzed, histoblot showed that the six proteins were widely expressed in the brain, with mostly an overlapping pattern throughout postnatal development. In the hippocampus, immunoelectron microscopy and quantitative analysis of immunoparticles for GABAB1, GABAB2, Gαo, Gβ5, and RGS7 revealed their progressive enrichment around excitatory synapses on dendritic spines of CA1 pyramidal cells toward P15. At presynaptic sites, GABAB receptors colocalize with CaV2.1, Gαo, Gβ5, and RGS7 in the active zone and extrasynaptic membranes of axon terminals, establishing synapses on dendritic spines of CA1 pyramidal cells. In the cerebellum, double immunofluorescence at P7 and P10 revealed the colocalization of GABAB1 and CaV2.1 in the whole dendritic tree of developing Purkinje cells. Immunoelectron microscopy at P15 showed that GABAB1, GABAB2, CaV2.1, Gαo, Gβ5, and RGS7 are distributed along the dendritic surface of Purkinje cells, enriched close to excitatory synapses in spines. Altogether, these data suggest that macromolecular complexes composed of GABAB1 /GABAB2/CaV2.1/ Gαo/Gβ5/RGS7 are pre-assembled during key stages of postnatal development in hippocampal and cerebellar neurons.}, author = {Aguado, Carolina and Alfaro-Ruiz, Rocío and Martínez-Poyato, María Llanos and Moreno-Martínez, Ana Esther and García-Madrona, Sebastián and Roldán-Sastre, Alberto and Alonso-Gómez, Pablo and Fernández, Miriam and Puertas-Avendaño, Ricardo and Shigemoto, Ryuichi and Martemyanov, Kirill A. and Luján, Rafael}, issn = {1699-5848}, journal = {Histology and Histopathology}, number = {12}, pages = {1967--1984}, publisher = {Sercrisma International}, title = {{Developmental regulation of GABAB receptors and downstream molecules in the mouse brain}}, doi = {10.14670/HH-18-970}, volume = {40}, year = {2025}, } @article{20660, abstract = {We used observations from the JWST Emission Line Survey (JELS) to measure the half-light radii (re) of 23 Hα-emitting starforming (SF) galaxies at z = 6.1 in the PRIMER/COSMOS field. Galaxy sizes were measured in JWST near-infrared camera observations in rest-frame Hα (tracing recent star formation) with the F466N and F470N narrow-band filters from JELS, and compared against rest-R- and V -band (tracing established stellar populations) and near-ultraviolet sizes. We find a size–stellar mass(re − M∗) relationship with a slope that is consistent with literature values at lower redshifts, though offset to lowersizes. We observe a large scatter in re at low stellar mass (M∗ < 10^8.4 Mo) which we believe is the result of bursty star formation histories (SFHs) of SF galaxies at the Epoch of Reionization (EoR). We find that the stellar and ionized gas components are similar in size at z = 6.1. The evidence of already-established stellar components in these Hα emitters (HAEs) indicates previous episodes of star formation have occurred. As such, following other JELS studies finding our HAEs are undergoing a current burst of star formation, we believe our results indicate that SF galaxies at the end of the EoR have already experienced a bursty SFH. From our re − M∗ relationship, we find re,F444W = 0.76 ± 0.46 kpc for fixed stellar mass M∗ = 10^9.25 M, which is in agreement with other observations and simulations of SF galaxies in the literature. We find a close-pair (major) merger fraction of (fmaj. merger =0.44 ± 0.22) fmerger = 0.43 ± 0.11 for galaxy separations d <~ 25 kpc, which is in agreement with other z ≈ 6 studies.}, author = {Stephenson, H. M.O. and Stott, J. P. and Pirie, C. A. and Duncan, K. J. and Mcleod, D. J. and Best, P. N. and Brinch, M. and Clausen, M. and Cochrane, R. K. and Dunlop, J. S. and Flury, S. R. and Geach, J. E. and Hale, C. L. and Ibar, E. and Li, Zefeng and Matthee, Jorryt J and Mclure, R. J. and Ossa-Fuentes, L. and Patrick, A. L. and Sobral, D. and Swinbank, A. M.}, issn = {1365-2966}, journal = {Monthly Notices of the Royal Astronomical Society}, number = {2}, pages = {1412--1431}, publisher = {Oxford University Press}, title = {{The JWST Emission Line Survey (JELS): The sizes and merger fraction of star-forming galaxies during the Epoch of Reionization}}, doi = {10.1093/mnras/staf1725}, volume = {544}, year = {2025}, }