@article{14834,
abstract = {Bacteria divide by binary fission. The protein machine responsible for this process is the divisome, a transient assembly of more than 30 proteins in and on the surface of the cytoplasmic membrane. Together, they constrict the cell envelope and remodel the peptidoglycan layer to eventually split the cell into two. For Escherichia coli, most molecular players involved in this process have probably been identified, but obtaining the quantitative information needed for a mechanistic understanding can often not be achieved from experiments in vivo alone. Since the discovery of the Z-ring more than 30 years ago, in vitro reconstitution experiments have been crucial to shed light on molecular processes normally hidden in the complex environment of the living cell. In this review, we summarize how rebuilding the divisome from purified components – or at least parts of it - have been instrumental to obtain the detailed mechanistic understanding of the bacterial cell division machinery that we have today.},
author = {Radler, Philipp and Loose, Martin},
issn = {0171-9335},
journal = {European Journal of Cell Biology},
keywords = {Cell Biology, General Medicine, Histology, Pathology and Forensic Medicine},
number = {1},
publisher = {Elsevier},
title = {{A dynamic duo: Understanding the roles of FtsZ and FtsA for Escherichia coli cell division through in vitro approaches}},
doi = {10.1016/j.ejcb.2023.151380},
volume = {103},
year = {2024},
}
@article{14841,
abstract = {De novo heterozygous variants in KCNC2 encoding the voltage-gated potassium (K+) channel subunit Kv3.2 are a recently described cause of developmental and epileptic encephalopathy (DEE). A de novo variant in KCNC2 c.374G > A (p.Cys125Tyr) was identified via exome sequencing in a patient with DEE. Relative to wild-type Kv3.2, Kv3.2-p.Cys125Tyr induces K+ currents exhibiting a large hyperpolarizing shift in the voltage dependence of activation, accelerated activation, and delayed deactivation consistent with a relative stabilization of the open conformation, along with increased current density. Leveraging the cryogenic electron microscopy (cryo-EM) structure of Kv3.1, molecular dynamic simulations suggest that a strong π-π stacking interaction between the variant Tyr125 and Tyr156 in the α-6 helix of the T1 domain promotes a relative stabilization of the open conformation of the channel, which underlies the observed gain of function. A multicompartment computational model of a Kv3-expressing parvalbumin-positive cerebral cortex fast-spiking γ-aminobutyric acidergic (GABAergic) interneuron (PV-IN) demonstrates how the Kv3.2-Cys125Tyr variant impairs neuronal excitability and dysregulates inhibition in cerebral cortex circuits to explain the resulting epilepsy.},
author = {Clatot, Jerome and Currin, Christopher and Liang, Qiansheng and Pipatpolkai, Tanadet and Massey, Shavonne L. and Helbig, Ingo and Delemotte, Lucie and Vogels, Tim P and Covarrubias, Manuel and Goldberg, Ethan M.},
issn = {1091-6490},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
number = {3},
publisher = {National Academy of Sciences},
title = {{A structurally precise mechanism links an epilepsy-associated KCNC2 potassium channel mutation to interneuron dysfunction}},
doi = {10.1073/pnas.2307776121},
volume = {121},
year = {2024},
}
@article{14845,
abstract = {We study a linear rotor in a bosonic bath within the angulon formalism. Our focus is on systems where isotropic or anisotropic impurity-boson interactions support a shallow bound state. To study the fate of the angulon in the vicinity of bound-state formation, we formulate a beyond-linear-coupling angulon Hamiltonian. First, we use it to study attractive, spherically symmetric impurity-boson interactions for which the linear rotor can be mapped onto a static impurity. The well-known polaron formalism provides an adequate description in this limit. Second, we consider anisotropic potentials, and show that the presence of a shallow bound state with pronounced anisotropic character leads to a many-body instability that washes out the angulon dynamics.},
author = {Dome, Tibor and Volosniev, Artem and Ghazaryan, Areg and Safari, Laleh and Schmidt, Richard and Lemeshko, Mikhail},
issn = {2469-9969},
journal = {Physical Review B},
number = {1},
publisher = {American Physical Society},
title = {{Linear rotor in an ideal Bose gas near the threshold for binding}},
doi = {10.1103/PhysRevB.109.014102},
volume = {109},
year = {2024},
}
@article{14851,
abstract = {Die Quantenrotation ist ein spannendes Phänomen, das in vielen verschiedenen Systemen auftritt, von Molekülen und Atomen bis hin zu subatomaren Teilchen wie Neutronen und Protonen. Durch den Einsatz von starken Laserpulsen ist es möglich, die mathematisch anspruchsvolle Topologie der Rotation von Molekülen aufzudecken und topologisch geschützte Zustände zu erzeugen, die unerwartetes Verhalten zeigen. Diese Entdeckungen könnten Auswirkungen auf die Molekülphysik und physikalische Chemie haben und die Entwicklung neuer Technologien ermöglichen. Die Verbindung von Quantenrotation und Topologie stellt ein aufregendes, interdisziplinäres Forschungsfeld dar und bietet neue Wege zur Kontrolle und Nutzung von quantenmechanischen Phänomenen.},
author = {Karle, Volker and Lemeshko, Mikhail},
issn = {1521-3943},
journal = {Physik in unserer Zeit},
keywords = {General Earth and Planetary Sciences, General Environmental Science},
number = {1},
pages = {28--33},
publisher = {Wiley},
title = {{Die faszinierende Topologie rotierender Quanten}},
doi = {10.1002/piuz.202301690},
volume = {55},
year = {2024},
}
@article{14884,
abstract = {We perform a stochastic homogenization analysis for composite materials exhibiting a random microstructure. Under the assumptions of stationarity and ergodicity, we characterize the Gamma-limit of a micromagnetic energy functional defined on magnetizations taking value in the unit sphere and including both symmetric and antisymmetric exchange contributions. This Gamma-limit corresponds to a micromagnetic energy functional with homogeneous coefficients. We provide explicit formulas for the effective magnetic properties of the composite material in terms of homogenization correctors. Additionally, the variational analysis of the two exchange energy terms is performed in the more general setting of functionals defined on manifold-valued maps with Sobolev regularity, in the case in which the target manifold is a bounded, orientable smooth surface with tubular neighborhood of uniform thickness. Eventually, we present an explicit characterization of minimizers of the effective exchange in the case of magnetic multilayers, providing quantitative evidence of Dzyaloshinskii’s predictions on the emergence of helical structures in composite ferromagnetic materials with stochastic microstructure.},
author = {Davoli, Elisa and D’Elia, Lorenza and Ingmanns, Jonas},
issn = {1432-1467},
journal = {Journal of Nonlinear Science},
number = {2},
publisher = {Springer Nature},
title = {{Stochastic homogenization of micromagnetic energies and emergence of magnetic skyrmions}},
doi = {10.1007/s00332-023-10005-3},
volume = {34},
year = {2024},
}
@article{14886,
abstract = {It is a basic principle that an effect cannot come before the cause. Dispersive relations that follow from this fundamental fact have proven to be an indispensable tool in physics and engineering. They are most powerful in the domain of linear response where they are known as Kramers-Kronig relations. However, when it comes to nonlinear phenomena the implications of causality are much less explored, apart from several notable exceptions. Here in this paper we demonstrate how to apply the dispersive formalism to analyze the ultrafast nonlinear response in the context of the paradigmatic nonlinear Kerr effect. We find that the requirement of causality introduces a noticeable effect even under assumption that Kerr effect is mediated by quasi-instantaneous off-resonant electronic hyperpolarizability. We confirm this by experimentally measuring the time-resolved Kerr dynamics in GaAs by means of a hybrid pump-probe Mach-Zehnder interferometer and demonstrate the presence of an intrinsic lagging between amplitude and phase responses as predicted by dispersive analysis. Our results describe a general property of the time-resolved nonlinear processes thereby highlighting the importance of accounting for dispersive effects in the nonlinear optical processes involving ultrashort pulses.},
author = {Lorenc, Dusan and Alpichshev, Zhanybek},
issn = {2643-1564},
journal = {Physical Review Research},
number = {1},
publisher = {American Physical Society},
title = {{Dispersive effects in ultrafast nonlinear phenomena: The case of optical Kerr effect}},
doi = {10.1103/PhysRevResearch.6.013042},
volume = {6},
year = {2024},
}
@article{14887,
abstract = {Episodic memories are encoded by experience-activated neuronal ensembles that remain necessary and sufficient for recall. However, the temporal evolution of memory engrams after initial encoding is unclear. In this study, we employed computational and experimental approaches to examine how the neural composition and selectivity of engrams change with memory consolidation. Our spiking neural network model yielded testable predictions: memories transition from unselective to selective as neurons drop out of and drop into engrams; inhibitory activity during recall is essential for memory selectivity; and inhibitory synaptic plasticity during memory consolidation is critical for engrams to become selective. Using activity-dependent labeling, longitudinal calcium imaging and a combination of optogenetic and chemogenetic manipulations in mouse dentate gyrus, we conducted contextual fear conditioning experiments that supported our model’s predictions. Our results reveal that memory engrams are dynamic and that changes in engram composition mediated by inhibitory plasticity are crucial for the emergence of memory selectivity.},
author = {Feitosa Tomé, Douglas and Zhang, Ying and Aida, Tomomi and Mosto, Olivia and Lu, Yifeng and Chen, Mandy and Sadeh, Sadra and Roy, Dheeraj S. and Clopath, Claudia},
issn = {1546-1726},
journal = {Nature Neuroscience},
pages = {561--572},
publisher = {Springer Nature},
title = {{Dynamic and selective engrams emerge with memory consolidation}},
doi = {10.1038/s41593-023-01551-w},
volume = {27},
year = {2024},
}
@inproceedings{14888,
abstract = {A face in a curve arrangement is called popular if it is bounded by the same curve multiple times. Motivated by the automatic generation of curved nonogram puzzles, we investigate possibilities to eliminate the popular faces in an arrangement by inserting a single additional curve. This turns out to be NP-hard; however, it becomes tractable when the number of popular faces is small: We present a probabilistic FPT-approach in the number of popular faces.},
author = {De Nooijer, Phoebe and Terziadis, Soeren and Weinberger, Alexandra and Masárová, Zuzana and Mchedlidze, Tamara and Löffler, Maarten and Rote, Günter},
booktitle = {31st International Symposium on Graph Drawing and Network Visualization},
isbn = {9783031492747},
issn = {1611-3349},
location = {Isola delle Femmine, Palermo, Italy},
pages = {18--33},
publisher = {Springer Nature},
title = {{Removing popular faces in curve arrangements}},
doi = {10.1007/978-3-031-49275-4_2},
volume = {14466},
year = {2024},
}
@article{14930,
abstract = {In this paper we investigate locally free representations of a quiver Q over a commutative Frobenius algebra R by arithmetic Fourier transform. When the base field is finite we prove that the number of isomorphism classes of absolutely indecomposable locally free representations of fixed rank is independent of the orientation of Q. We also prove that the number of isomorphism classes of locally free absolutely indecomposable representations of the preprojective algebra of Q over R equals the number of isomorphism classes of locally free absolutely indecomposable representations of Q over R[t]/(t2). Using these results together with results of Geiss, Leclerc and Schröer we give, when k is algebraically closed, a classification of pairs (Q, R) such that the set of isomorphism classes of indecomposable locally free representations of Q over R is finite. Finally when the representation is free of rank 1 at each vertex of Q, we study the function that counts the number of isomorphism classes of absolutely indecomposable locally free representations of Q over the Frobenius algebra Fq[t]/(tr). We prove that they are polynomial in q and their generating function is rational and satisfies a functional equation.},
author = {Hausel, Tamás and Letellier, Emmanuel and Rodriguez-Villegas, Fernando},
issn = {1420-9020},
journal = {Selecta Mathematica},
number = {2},
publisher = {Springer Nature},
title = {{Locally free representations of quivers over commutative Frobenius algebras}},
doi = {10.1007/s00029-023-00914-2},
volume = {30},
year = {2024},
}
@article{14932,
abstract = {The huge antlers of the extinct Irish elk have invited evolutionary speculation since Darwin. In the 1970s, Stephen Jay Gould presented the first extensive data on antler size in the Irish elk and combined these with comparative data from other deer to test the hypothesis that the gigantic antlers were the outcome of a positive allometry that constrained large-bodied deer to have proportionally even larger antlers. He concluded that the Irish elk had antlers as predicted for its size and interpreted this within his emerging framework of developmental constraints as an explanatory factor in evolution. Here we reanalyze antler allometry based on new morphometric data for 57 taxa of the family Cervidae. We also present a new phylogeny for the Cervidae, which we use for comparative analyses. In contrast to Gould, we find that the antlers of Irish elk were larger than predicted from the allometry within the true deer, Cervini, as analyzed by Gould, but follow the allometry across Cervidae as a whole. After dissecting the discrepancy, we reject the allometric-constraint hypothesis because, contrary to Gould, we find no similarity between static and evolutionary allometries, and because we document extensive non-allometric evolution of antler size across the Cervidae.},
author = {Tsuboi, Masahito and Kopperud, Bjørn Tore and Matschiner, Michael and Grabowski, Mark and Syrowatka, Chrsitine and Pélabon, Christophe and Hansen, Thomas F.},
issn = {1934-2845},
journal = {Evolutionary Biology},
pages = {149--165},
publisher = {Springer Nature},
title = {{Antler allometry, the Irish elk and Gould revisited}},
doi = {10.1007/s11692-023-09624-1},
volume = {51},
year = {2024},
}
@article{14933,
abstract = {Centrioles are part of centrosomes and cilia, which are microtubule organising centres (MTOC) with diverse functions. Despite their stability, centrioles can disappear during differentiation, such as in oocytes, but little is known about the regulation of their structural integrity. Our previous research revealed that the pericentriolar material (PCM) that surrounds centrioles and its recruiter, Polo kinase, are downregulated in oogenesis and sufficient for maintaining both centrosome structural integrity and MTOC activity. We now show that the expression of specific components of the centriole cartwheel and wall, including ANA1/CEP295, is essential for maintaining centrosome integrity. We find that Polo kinase requires ANA1 to promote centriole stability in cultured cells and eggs. In addition, ANA1 expression prevents the loss of centrioles observed upon PCM-downregulation. However, the centrioles maintained by overexpressing and tethering ANA1 are inactive, unlike the MTOCs observed upon tethering Polo kinase. These findings demonstrate that several centriole components are needed to maintain centrosome structure. Our study also highlights that centrioles are more dynamic than previously believed, with their structural stability relying on the continuous expression of multiple components.},
author = {Pimenta-Marques, Ana and Perestrelo, Tania and Dos Reis Rodrigues, Patricia and Duarte, Paulo and Ferreira-Silva, Ana and Lince-Faria, Mariana and Bettencourt-Dias, Mónica},
issn = {1469-3178},
journal = {EMBO Reports},
number = {1},
pages = {102--127},
publisher = {Embo Press},
title = {{Ana1/CEP295 is an essential player in the centrosome maintenance program regulated by Polo kinase and the PCM}},
doi = {10.1038/s44319-023-00020-6},
volume = {25},
year = {2024},
}
@article{14986,
abstract = {We prove a version of the tamely ramified geometric Langlands correspondence in positive characteristic for GLn(k). Let k be an algebraically closed field of characteristic p>n. Let X be a smooth projective curve over k with marked points, and fix a parabolic subgroup of GLn(k) at each marked point. We denote by Bunn,P the moduli stack of (quasi-)parabolic vector bundles on X, and by Locn,P the moduli stack of parabolic flat connections such that the residue is nilpotent with respect to the parabolic reduction at each marked point. We construct an equivalence between the bounded derived category Db(Qcoh(Loc0n,P)) of quasi-coherent sheaves on an open substack Loc0n,P⊂Locn,P, and the bounded derived category Db(D0Bunn,P-mod) of D0Bunn,P-modules, where D0Bunn,P is a localization of DBunn,P the sheaf of crystalline differential operators on Bunn,P. Thus we extend the work of Bezrukavnikov-Braverman to the tamely ramified case. We also prove a correspondence between flat connections on X with regular singularities and meromorphic Higgs bundles on the Frobenius twist X(1) of X with first order poles .},
author = {Shen, Shiyu},
issn = {1687-0247},
journal = {International Mathematics Research Notices},
keywords = {General Mathematics},
number = {7},
pages = {6176--6208},
publisher = {Oxford University Press},
title = {{Tamely ramified geometric Langlands correspondence in positive characteristic}},
doi = {10.1093/imrn/rnae005},
volume = {2024},
year = {2024},
}
@article{15002,
abstract = {The lattice Schwinger model, the discrete version of QED in
1
+
1
dimensions, is a well-studied test bench for lattice gauge theories. Here, we study the fractal properties of this model. We reveal the self-similarity of the ground state, which allows us to develop a recurrent procedure for finding the ground-state wave functions and predicting ground-state energies. We present the results of recurrently calculating ground-state wave functions using the fractal Ansatz and automized software package for fractal image processing. In certain parameter regimes, just a few terms are enough for our recurrent procedure to predict ground-state energies close to the exact ones for several hundreds of sites. Our findings pave the way to understanding the complexity of calculating many-body wave functions in terms of their fractal properties as well as finding new links between condensed matter and high-energy lattice models.},
author = {Petrova, Elena and Tiunov, Egor S. and Bañuls, Mari Carmen and Fedorov, Aleksey K.},
issn = {1079-7114},
journal = {Physical Review Letters},
number = {5},
publisher = {American Physical Society},
title = {{Fractal states of the Schwinger model}},
doi = {10.1103/PhysRevLett.132.050401},
volume = {132},
year = {2024},
}
@article{15003,
abstract = {Magnetic frustration allows to access novel and intriguing properties of magnetic systems and has been explored mainly in planar triangular-like arrays of magnetic ions. In this work, we describe the phosphide Ce6Ni6P17, where the Ce+3 ions accommodate in a body-centered cubic lattice of Ce6 regular octahedra. From measurements of magnetization, specific heat, and resistivity, we determine a rich phase diagram as a function of temperature and magnetic field in which different magnetic phases are found. Besides clear evidence of magnetic frustration is obtained from entropy analysis. At zero field, a second-order antiferromagnetic transition occurs at TN1≈1 K followed by a first-order transition at TN2≈0.45 K. With magnetic field new magnetic phases appear, including a weakly first-order transition which ends in a classical critical point and a third magnetic phase. We also study the exact solution of the spin-1/2 Heisenberg model in an octahedron which allows us a qualitative understanding of the phase diagram and compare with the experimental results.},
author = {Franco, D. G. and Avalos, R. and Hafner, D. and Modic, Kimberly A and Prots, Yu and Stockert, O. and Hoser, A. and Moll, P. J.W. and Brando, M. and Aligia, A. A. and Geibel, C.},
issn = {2469-9969},
journal = {Physical Review B},
number = {5},
publisher = {American Physical Society},
title = {{Frustrated magnetism in octahedra-based Ce6 Ni6 P17}},
doi = {10.1103/PhysRevB.109.054405},
volume = {109},
year = {2024},
}
@article{15004,
abstract = {The impulsive limit (the “sudden approximation”) has been widely employed to describe the interaction between molecules and short, far-off-resonant laser pulses. This approximation assumes that the timescale of the laser-molecule interaction is significantly shorter than the internal rotational period of the molecule, resulting in the rotational motion being instantaneously “frozen” during the interaction. This simplified description of the laser-molecule interaction is incorporated in various theoretical models predicting rotational dynamics of molecules driven by short laser pulses. In this theoretical work, we develop an effective theory for ultrashort laser pulses by examining the full time-evolution operator and solving the time-dependent Schrödinger equation at the operator level. Our findings reveal a critical angular momentum, lcrit, at which the impulsive limit breaks down. In other words, the validity of the sudden approximation depends not only on the pulse duration but also on its intensity, since the latter determines how many angular momentum states are populated. We explore both ultrashort multicycle (Gaussian) pulses and the somewhat less studied half-cycle pulses, which produce distinct effective potentials. We discuss the limitations of the impulsive limit and propose a method that rescales the effective matrix elements, enabling an improved and more accurate description of laser-molecule interactions.},
author = {Karle, Volker and Lemeshko, Mikhail},
issn = {2469-9934},
journal = {Physical Review A},
number = {2},
publisher = {American Physical Society},
title = {{Modeling laser pulses as δ kicks: Reevaluating the impulsive limit in molecular rotational dynamics}},
doi = {10.1103/PhysRevA.109.023101},
volume = {109},
year = {2024},
}
@inproceedings{15006,
abstract = {Graphical games are a useful framework for modeling the interactions of (selfish) agents who are connected via an underlying topology and whose behaviors influence each other. They have wide applications ranging from computer science to economics and biology. Yet, even though an agent’s payoff only depends on the actions of their direct neighbors in graphical games, computing the Nash equilibria and making statements about the convergence time of "natural" local dynamics in particular can be highly challenging. In this work, we present a novel approach for classifying complexity of Nash equilibria in graphical games by establishing a connection to local graph algorithms, a subfield of distributed computing. In particular, we make the observation that the equilibria of graphical games are equivalent to locally verifiable labelings (LVL) in graphs; vertex labelings which are verifiable with constant-round local algorithms. This connection allows us to derive novel lower bounds on the convergence time to equilibrium of best-response dynamics in graphical games. Since we establish that distributed convergence can sometimes be provably slow, we also introduce and give bounds on an intuitive notion of "time-constrained" inefficiency of best responses. We exemplify how our results can be used in the implementation of mechanisms that ensure convergence of best responses to a Nash equilibrium. Our results thus also give insight into the convergence of strategy-proof algorithms for graphical games, which is still not well understood.},
author = {Hirvonen, Juho and Schmid, Laura and Chatterjee, Krishnendu and Schmid, Stefan},
booktitle = {27th International Conference on Principles of Distributed Systems},
isbn = {9783959773089},
issn = {1868-8969},
location = {Tokyo, Japan},
publisher = {Schloss Dagstuhl - Leibniz-Zentrum für Informatik},
title = {{On the convergence time in graphical games: A locality-sensitive approach}},
doi = {10.4230/LIPIcs.OPODIS.2023.11},
volume = {286},
year = {2024},
}
@inproceedings{15007,
abstract = {Traditional blockchains grant the miner of a block full control not only over which transactions but also their order. This constitutes a major flaw discovered with the introduction of decentralized finance and allows miners to perform MEV attacks. In this paper, we address the issue of sandwich attacks by providing a construction that takes as input a blockchain protocol and outputs a new blockchain protocol with the same security but in which sandwich attacks are not profitable. Furthermore, our protocol is fully decentralized with no trusted third parties or heavy cryptography primitives and carries a linear increase in latency and minimum computation overhead.},
author = {Alpos, Orestis and Amores-Sesar, Ignacio and Cachin, Christian and Yeo, Michelle X},
booktitle = {27th International Conference on Principles of Distributed Systems},
isbn = {9783959773089},
issn = {1868-8969},
location = {Tokyo, Japan},
publisher = {Schloss Dagstuhl - Leibniz-Zentrum für Informatik},
title = {{Eating sandwiches: Modular and lightweight elimination of transaction reordering attacks}},
doi = {10.4230/LIPIcs.OPODIS.2023.12},
volume = {286},
year = {2024},
}
@inproceedings{15008,
abstract = {Oblivious routing is a well-studied paradigm that uses static precomputed routing tables for selecting routing paths within a network. Existing oblivious routing schemes with polylogarithmic competitive ratio for general networks are tree-based, in the sense that routing is performed according to a convex combination of trees. However, this restriction to trees leads to a construction that has time quadratic in the size of the network and does not parallelize well.
In this paper we study oblivious routing schemes based on electrical routing. In particular, we show that general networks with n vertices and m edges admit a routing scheme that has competitive ratio O(log² n) and consists of a convex combination of only O(√m) electrical routings. This immediately leads to an improved construction algorithm with time Õ(m^{3/2}) that can also be implemented in parallel with Õ(√m) depth.},
author = {Goranci, Gramoz and Henzinger, Monika H and Räcke, Harald and Sachdeva, Sushant and Sricharan, A. R.},
booktitle = {15th Innovations in Theoretical Computer Science Conference},
isbn = {9783959773096},
issn = {1868-8969},
location = {Berkeley, CA, United States},
publisher = {Schloss Dagstuhl - Leibniz-Zentrum für Informatik},
title = {{Electrical flows for polylogarithmic competitive oblivious routing}},
doi = {10.4230/LIPIcs.ITCS.2024.55},
volume = {287},
year = {2024},
}
@article{15025,
abstract = {We consider quadratic forms of deterministic matrices A evaluated at the random eigenvectors of a large N×N GOE or GUE matrix, or equivalently evaluated at the columns of a Haar-orthogonal or Haar-unitary random matrix. We prove that, as long as the deterministic matrix has rank much smaller than √N, the distributions of the extrema of these quadratic forms are asymptotically the same as if the eigenvectors were independent Gaussians. This reduces the problem to Gaussian computations, which we carry out in several cases to illustrate our result, finding Gumbel or Weibull limiting distributions depending on the signature of A. Our result also naturally applies to the eigenvectors of any invariant ensemble.},
author = {Erdös, László and McKenna, Benjamin},
issn = {1050-5164},
journal = {Annals of Applied Probability},
number = {1B},
pages = {1623--1662},
publisher = {Institute of Mathematical Statistics},
title = {{Extremal statistics of quadratic forms of GOE/GUE eigenvectors}},
doi = {10.1214/23-AAP2000},
volume = {34},
year = {2024},
}
@article{15033,
abstract = {The GNOM (GN) Guanine nucleotide Exchange Factor for ARF small GTPases (ARF-GEF) is among the best studied trafficking regulators in plants, playing crucial and unique developmental roles in patterning and polarity. The current models place GN at the Golgi apparatus (GA), where it mediates secretion/recycling, and at the plasma membrane (PM) presumably contributing to clathrin-mediated endocytosis (CME). The mechanistic basis of the developmental function of GN, distinct from the other ARF-GEFs including its closest homologue GNOM-LIKE1 (GNL1), remains elusive. Insights from this study largely extend the current notions of GN function. We show that GN, but not GNL1, localizes to the cell periphery at long-lived structures distinct from clathrin-coated pits, while CME and secretion proceed normally in gn knockouts. The functional GN mutant variant GNfewerroots, absent from the GA, suggests that the cell periphery is the major site of GN action responsible for its developmental function. Following inhibition by Brefeldin A, GN, but not GNL1, relocates to the PM likely on exocytic vesicles, suggesting selective molecular associations en route to the cell periphery. A study of GN-GNL1 chimeric ARF-GEFs indicates that all GN domains contribute to the specific GN function in a partially redundant manner. Together, this study offers significant steps toward the elucidation of the mechanism underlying unique cellular and development functions of GNOM.},
author = {Adamowski, Maciek and Matijevic, Ivana and Friml, Jiří},
issn = {2050-084X},
journal = {eLife},
keywords = {General Immunology and Microbiology, General Biochemistry, Genetics and Molecular Biology, General Medicine, General Neuroscience},
publisher = {eLife Sciences Publications},
title = {{Developmental patterning function of GNOM ARF-GEF mediated from the cell periphery}},
doi = {10.7554/elife.68993},
volume = {13},
year = {2024},
}