@article{15339, abstract = {We define even very stable Higgs bundles and study the Hitchin map restricted to their upward flows. In the GLn case, we classify the type (1,…,1) examples, and find that they are governed by a root system formed by the roots of even height. We discuss how the spectrum of equivariant cohomology of real and quaternionic Grassmannians, 4n-spheres and the real Cayley plane appear to describe the Hitchin map on even cominuscule upward flows. The even upward flows in question are the same as upward flows in Higgs bundle moduli spaces for quasi-split inner real forms. The latter spaces have been pioneered by Oscar García-Prada and his collaborators.}, author = {González, Miguel and Hausel, Tamás}, issn = {1793-6519}, journal = {International Journal of Mathematics}, number = {09}, publisher = {World Scientific Publishing}, title = {{Hitchin map on even very stable upward flows}}, doi = {10.1142/S0129167X2441009X}, volume = {35}, year = {2024}, } @article{15348, abstract = {We report on synthesis of highly crystalline polythiophene and its application in supercapacitor electrodes. The material exhibits a remarkably stable electrochemical behavior and an excellent device performance. The device delivers an electrode specific capacitance (Csp) of 129.13F g−1, Cell Csp of 32.28F g−1 at 0.5 A/g; energy, and power densities of ∼ 3 Wh kg−1 and 250 W kg -1, respectively at 0.5 A/g. Also, it exhibits an excellent retention of Cell Csp and coulombic efficiency up to ∼ 95 % over 10,000 continuous galvanostatic charge discharge (GCD) cycles indicating a remarkable performance by a standalone, pristine and undoped polythiophene. Electrochemical impedance spectroscopy (EIS) studies further suggest material’s stable capacitive behavior. The material’s enhanced electrochemical properties, stable behavior and outstanding performance in device application are attributed to the crystalline phases present in the polymer matrix achievable via a slow rate of synthesis; overall, an edge over other conventional synthesis methods.}, author = {Mahato, Neelima and Singh, Saurabh and Sreekanth, T. V.M. and Yoo, Kisoo and Kim, Jonghoon}, issn = {1873-4979}, journal = {Materials Letters}, publisher = {Elsevier}, title = {{In-situ engineered highly crystalline polythiophene empowered electrochemical capacitor-I: Synthesis, characterization, and electrochemical charge storage}}, doi = {10.1016/j.matlet.2024.136483}, volume = {365}, year = {2024}, } @article{15350, abstract = {We extend three related results from the analysis of influences of Boolean functions to the quantum setting, namely the KKL theorem, Friedgut’s Junta theorem and Talagrand’s variance inequality for geometric influences. Our results are derived by a joint use of recently studied hypercontractivity and gradient estimates. These generic tools also allow us to derive generalizations of these results in a general von Neumann algebraic setting beyond the case of the quantum hypercube, including examples in infinite dimensions relevant to quantum information theory such as continuous variables quantum systems. Finally, we comment on the implications of our results as regards to noncommutative extensions of isoperimetric type inequalities, quantum circuit complexity lower bounds and the learnability of quantum observables.}, author = {Rouzé, Cambyse and Wirth, Melchior and Zhang, Haonan}, issn = {1432-0916}, journal = {Communications in Mathematical Physics}, number = {4}, publisher = {Springer Nature}, title = {{Quantum Talagrand, KKL and Friedgut’s theorems and the learnability of quantum boolean functions}}, doi = {10.1007/s00220-024-04981-0}, volume = {405}, year = {2024}, } @article{15356, abstract = {Identifying efficient active sites for the direct synthesis of hydrogen peroxide over Pd-based catalysts has been a subject of considerable debate. In this study, we employ particle swarm optimization method and density functional theory to explore the H2O2 synthesis mechanism on Pd, PdO, and the partially oxidized surface (Pd9OX). A comprehensive mechanism for Pd9OX is elucidated, and subsequent coverage-dependent kinetic analysis allows for a quantitative assessment of catalytic performance at the interphase. Our findings conclusively establish that the interphase between Pd and PdO represents the optimal active site. Phase diagram analysis further aids in determining stable structures under reaction conditions. At 298.15 K and under oxygen balance, the Pd9O6 surface remains stable throughout the reaction, demonstrating high activity and selectivity. This work underscores the significance of the interphase in comprehending catalytic performance and unveils promising avenues for optimizing catalyst performance by controlling reaction conditions and surface composition.}, author = {Zhao, Jinyan and Yao, Zihao and Bunting, Rhys and Wang, Yaqiu and Wang, Jianguo}, issn = {0009-2509}, journal = {Chemical Engineering Science}, publisher = {Elsevier}, title = {{Identifying Pd9OX as the optimum catalyst for the direct synthesis of H2O2 through microkinetic modeling with coverage effects}}, doi = {10.1016/j.ces.2024.120199}, volume = {295}, year = {2024}, } @article{15357, abstract = {There is a growing interest in cost-effective polycrystalline SnSe-based thermoelectric (TE) materials, which are able to replace the high performance but mechanically fragile and costly single-crystalline SnSe. In this study, we present a low-temperature solution-based approach to produce SnSe-PbSe nanocomposites with outstanding TE performance. Our method involves combining surfactant-free SnSe particles with oleate-capped PbSe nanocrystals in specific ratios, followed by thermal annealing and consolidation using spark plasma sintering. These nanocomposites are characterized by distinct compositional and structural properties that significantly impact their transport properties. In particular, the addition of oleate-capped PbSe nanocrystals results in: i) a reduction in the electrostatically adsorbed Na at the surface of the SnSe particles; ii) a reduction of Sn vacancies due to alloying with Pb; iii) an increase in grain boundary density; and iv) the formation of PbSnSe secondary phases. Notably, the SnSe-2.5 %PbSe nanocomposites demonstrate a 30 % decrease in thermal conductivity compared to that of the SnSe matrix. This reduction contributes to a maximum figure of merit (zT) of 1.75 at 788 K with a high average zT value of ca. 1.2 in the medium temperature range of 573–773 K. These values represent one of the highest reported in polycrystalline SnSe materials, showcasing the potential of our fabricated SnSe-PbSe nanocomposites for cost-effective TE applications.}, author = {Liu, Yu and Lee, Seungho and Fiedler, Christine and Spadaro, Maria Chiara and Chang, Cheng and Li, Mingquan and Hong, Min and Arbiol, Jordi and Ibáñez, Maria}, issn = {1385-8947}, journal = {Chemical Engineering Journal}, publisher = {Elsevier}, title = {{Enhancing thermoelectric performance of solutionpProcessed polycrystalline SnSe with PbSe nanocrystals}}, doi = {10.1016/j.cej.2024.151405}, volume = {490}, year = {2024}, } @article{15358, abstract = {We consider how a population of N haploid individuals responds to directional selection on standing variation, with no new variation from recombination or mutation. Individuals have trait values z1,…,zN, which are drawn from a distribution ψ; the fitness of individual i is proportional to [Formula: see text] . For illustration, we consider the Laplace and Gaussian distributions, which are parametrised only by the variance V0, and show that for large N, there is a scaling limit which depends on a single parameter NV0. When selection is weak relative to drift (NV0≪1), the variance decreases exponentially at rate 1/N, and the expected ultimate gain in log fitness (scaled by V0), is just NV0, which is the same as Robertson's (1960) prediction for a sexual population. In contrast, when selection is strong relative to drift (NV0≫1), the ultimate gain can be found by approximating the establishment of alleles by a branching process in which each allele competes independently with the population mean and the fittest allele to establish is certain to fix. Then, if the probability of survival to time t∼1/V0 of an allele with value z is P(z), with mean P¯, the winning allele is the fittest of NP¯ survivors drawn from a distribution ψP/P¯. The expected ultimate change is ∼2log(1.15NV0) for a Gaussian distribution, and ∼-12log0.36NV0-log-log0.36NV0 for a Laplace distribution. This approach also predicts the variability of the process, and its dynamics; we show that in the strong selection regime, the expected genetic variance decreases as ∼t-3 at large times. We discuss how these results may be related to selection on standing variation that is spread along a linear chromosome.}, author = {Barton, Nicholas H and Sachdeva, Himani}, issn = {1096-0325}, journal = {Theoretical Population Biology}, pages = {129--137}, publisher = {Elsevier}, title = {{Limits to selection on standing variation in an asexual population}}, doi = {10.1016/j.tpb.2024.04.001}, volume = {157}, year = {2024}, } @article{15360, abstract = {We investigate superradiant enhancements in the refrigeration performance of a set of N three-level systems that are collectively coupled to a hot and a cold thermal reservoir and are additionally subject to collective periodic (circular) driving. Assuming the system-reservoir coupling to be weak, we explore the regime of stronger periodic driving strengths by comparing collective weak driving, Floquet-Lindblad, and Floquet-Redfield master equations. We identify regimes where the power injected by the periodic driving is used to pump heat from the cold to the hot reservoir and derive analytic sufficient conditions for them based on a cycle analysis of the Floquet-Lindblad master equation. In those regimes, we also argue for which parameters collective enhancements like a quadratic scaling of the cooling current with N can be expected and support our arguments by numerical simulations.}, author = {Kolisnyk, Dmytro and Queißer, Friedemann and Schaller, Gernot and Schützhold, Ralf}, issn = {2331-7019}, journal = {Physical Review Applied}, number = {4}, publisher = {American Physical Society}, title = {{Floquet analysis of a superradiant many-qutrit refrigerator}}, doi = {10.1103/PhysRevApplied.21.044050}, volume = {21}, year = {2024}, } @inbook{15361, abstract = {Bimolecular fluorescence complementation (BiFC) is a powerful tool for studying protein-protein interactions in living cells. By fusing interacting proteins to fluorescent protein fragments, BiFC allows visualization of spatial localization patterns of protein complexes. This method has been adapted to a variety of expression systems in different organisms and is widely used to study protein interactions in plant cells. The Agrobacterium-mediated transient expression protocol for BiFC assays in Nicotiana benthamiana (N. benthamiana) leaf cells is widely used, but in this chapter, a method for BiFC assay using Arabidopsis thaliana protoplasts is presented.}, author = {Jayasree, Aswathy and Salava, Hymavathi and Nodzynski, Tomasz and Sravankumar, Thula}, booktitle = {Plant Functional Genomics}, editor = {Maghuly, Fatemeh}, isbn = {9781071637777}, issn = {1940-6029}, pages = {305--313}, publisher = {Springer Nature}, title = {{Protein-Protein Interactions Visualized by Bimolecular Fluorescence Complementation in Arabidopsis thaliana Protoplasts from Leaf}}, doi = {10.1007/978-1-0716-3778-4_21}, volume = {2787}, year = {2024}, } @article{15362, abstract = {Constitutional heterozygous pathogenic variants in the exonuclease domain of POLE and POLD1, which affect the proofreading activity of the corresponding polymerases, cause a cancer predisposition syndrome characterized by increased risk of gastrointestinal polyposis, colorectal cancer, endometrial cancer and other tumor types. The generally accepted explanation for the connection between the disruption of the proofreading activity of polymerases epsilon and delta and cancer development is through an increase in the somatic mutation rate. Here we studied an extended family with multiple members heterozygous for the pathogenic POLD1 variant c.1421T>C p.(Leu474Pro), which segregates with the polyposis and cancer phenotypes. Through the analysis of mutational patterns of patient-derived fibroblasts colonies and de novo mutations obtained by parent-offspring comparisons, we concluded that heterozygous POLD1 L474P just subtly increases the somatic and germline mutation burden. In contrast, tumors developed in individuals with a heterozygous mutation in the exonuclease domain of POLD1, including L474P, have an extremely high mutation rate (>100 mut/Mb) associated with signature SBS10d. We solved this contradiction through the observation that tumorigenesis involves somatic inactivation of the wildtype POLD1 allele. These results imply that exonuclease deficiency of polymerase delta has a recessive effect on mutation rate.}, author = {Andrianova, Maria A. and Seplyarskiy, Vladimir B. and Terradas, Mariona and Sánchez-Heras, Ana Beatriz and Mur, Pilar and Soto, José Luis and Aiza, Gemma and Borràs, Emma and Kondrashov, Fyodor and Kondrashov, Alexey S. and Bazykin, Georgii A. and Valle, Laura}, issn = {1476-5438}, journal = {European Journal of Human Genetics}, pages = {837--845}, publisher = {Springer Nature}, title = {{Discovery of recessive effect of human polymerase δ proofreading deficiency through mutational analysis of POLD1-mutated normal and cancer cells}}, doi = {10.1038/s41431-024-01598-8}, volume = {32}, year = {2024}, } @article{15367, abstract = {Two-dimensional semiconductor-superconductor heterostructures form the foundation of numerous nanoscale physical systems. However, measuring the properties of such heterostructures, and characterizing the semiconductor in-situ is challenging. A recent experimental study by [Phys. Rev. Lett. 128, 107701 (2022)] was able to probe the semiconductor within the heterostructure using microwave measurements of the superfluid density. This work revealed a rapid depletion of superfluid density in semiconductor, caused by the in-plane magnetic field which in presence of spin-orbit coupling creates so-called Bogoliubov Fermi surfaces. The experimental work used a simplified theoretical model that neglected the presence of non-magnetic disorder in the semiconductor, hence describing the data only qualitatively. Motivated by experiments, we introduce a theoretical model describing a disordered semiconductor with strong spin-orbit coupling that is proximitized by a superconductor. Our model provides specific predictions for the density of states and superfluid density. Presence of disorder leads to the emergence of a gapless superconducting phase, that may be viewed as a manifestation of Bogoliubov Fermi surface. When applied to real experimental data, our model showcases excellent quantitative agreement, enabling the extraction of material parameters such as mean free path and mobility, and estimating g-tensor after taking into account the orbital contribution of magnetic field. Our model can be used to probe in-situ parameters of other superconductor-semiconductor heterostructures and can be further extended to give access to transport properties.}, author = {Babkin, Serafim and Higginbotham, Andrew P and Serbyn, Maksym}, issn = {2542-4653}, journal = {SciPost Physics}, number = {5}, publisher = {SciPost Foundation}, title = {{Proximity-induced gapless superconductivity in two-dimensional Rashba semiconductor in magnetic field}}, doi = {10.21468/scipostphys.16.5.115}, volume = {16}, year = {2024}, } @article{15372, abstract = {CRISPR-Cas9 is a powerful tool for genome editing, but the strict requirement for an NGG protospacer-adjacent motif (PAM) sequence immediately next to the DNA target limits the number of editable genes. Recently developed Cas9 variants have been engineered with relaxed PAM requirements, including SpG-Cas9 (SpG) and the nearly PAM-less SpRY-Cas9 (SpRY). However, the molecular mechanisms of how SpRY recognizes all potential PAM sequences remains unclear. Here, we combine structural and biochemical approaches to determine how SpRY interrogates DNA and recognizes target sites. Divergent PAM sequences can be accommodated through conformational flexibility within the PAM-interacting region, which facilitates tight binding to off-target DNA sequences. Nuclease activation occurs ~1000-fold slower than for Streptococcus pyogenes Cas9, enabling us to directly visualize multiple on-pathway intermediate states. Experiments with SpG position it as an intermediate enzyme between Cas9 and SpRY. Our findings shed light on the molecular mechanisms of PAMless genome editing.}, author = {Hibshman, Grace N. and Bravo, Jack Peter Kelly and Hooper, Matthew M. and Dangerfield, Tyler L. and Zhang, Hongshan and Finkelstein, Ilya J. and Johnson, Kenneth A. and Taylor, David W.}, issn = {2041-1723}, journal = {Nature Communications}, publisher = {Springer Nature}, title = {{Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9}}, doi = {10.1038/s41467-024-47830-3}, volume = {15}, year = {2024}, } @article{15373, abstract = {In this article we prove a refined version of the Christensen–Evans theorem for generators of uniformly continuous GNS-symmetric quantum Markov semigroups. We use this result to show the existence of GNS-symmetric extensions of GNS-symmetric quantum Markov semigroups. In particular, this implies that the generators of GNS-symmetric quantum Markov semigroups on finite-dimensional von Neumann algebra can be written in the form specified by Alicki's theorem.}, author = {Wirth, Melchior}, issn = {1096-0783}, journal = {Journal of Functional Analysis}, number = {3}, publisher = {Elsevier}, title = {{Christensen–Evans theorem and extensions of GNS-symmetric quantum Markov semigroups}}, doi = {10.1016/j.jfa.2024.110475}, volume = {287}, year = {2024}, } @article{15374, abstract = {Clathrin-mediated endocytosis (CME) is an essential process of cargo uptake operating in all eukaryotes. In animals and yeast, BAR-SH3 domain proteins, endophilins and amphiphysins, function at the conclusion of CME to recruit factors for vesicle scission and uncoating. Arabidopsis thaliana contains the BAR-SH3 domain proteins SH3P1–SH3P3, but their role is poorly understood. Here, we identify SH3Ps as functional homologs of endophilin/amphiphysin. SH3P1–SH3P3 bind to discrete foci at the plasma membrane (PM), and SH3P2 recruits late to a subset of clathrin-coated pits. The SH3P2 PM recruitment pattern is nearly identical to its interactor, a putative uncoating factor, AUXILIN-LIKE1. Notably, SH3P1–SH3P3 are required for most of AUXILIN-LIKE1 recruitment to the PM. This indicates a plant-specific modification of CME, where BAR-SH3 proteins recruit auxilin-like uncoating factors rather than the uncoating phosphatases, synaptojanins. SH3P1–SH3P3 act redundantly in overall CME with the plant-specific endocytic adaptor TPLATE complex but not due to an SH3 domain in its TASH3 subunit.}, author = {Adamowski, Maciek and Randuch, Marek and Matijevic, Ivana and Narasimhan, Madhumitha and Friml, Jiří}, issn = {2211-1247}, journal = {Cell Reports}, number = {5}, publisher = {Cell Press}, title = {{SH3Ps recruit auxilin-like vesicle uncoating factors for clathrin-mediated endocytosis}}, doi = {10.1016/j.celrep.2024.114195}, volume = {43}, year = {2024}, } @article{15375, abstract = {In the eukaryotic nucleus, heterochromatin forms highly condensed, visible foci known as heterochromatin foci (HF). These HF are enriched with linker histone H1, a key player in heterochromatin condensation and silencing. However, it is unknown how H1 aggregates HF and condenses heterochromatin. In this study, we established that H1 facilitates heterochromatin condensation by enhancing inter- and intrachromosomal interactions between and within heterochromatic regions of the Arabidopsis (Arabidopsis thaliana) genome. We demonstrated that H1 drives HF formation via phase separation, which requires its C-terminal intrinsically disordered region (C-IDR). A truncated H1 lacking the C-IDR fails to form foci or recover HF in the h1 mutant background, whereas C-IDR with a short stretch of the globular domain (18 out of 71 amino acids) is sufficient to rescue both defects. In addition, C-IDR is essential for H1's roles in regulating nucleosome repeat length and DNA methylation in Arabidopsis, indicating that phase separation capability is required for chromatin functions of H1. Our data suggest that bacterial H1-like proteins, which have been shown to condense DNA, are intrinsically disordered and capable of mediating phase separation. Therefore, we propose that phase separation mediated by H1 or H1-like proteins may represent an ancient mechanism for condensing chromatin and DNA.}, author = {He, Shengbo and Yu, Yiming and Wang, Liang and Zhang, Jingyi and Bai, Zhengyong and Li, Guohong and Li, Pilong and Feng, Xiaoqi}, issn = {1532-298X}, journal = {The Plant Cell}, number = {5}, pages = {1829--1843}, publisher = {Oxford University Press}, title = {{Linker histone H1 drives heterochromatin condensation via phase separation in Arabidopsis}}, doi = {10.1093/plcell/koae034}, volume = {36}, year = {2024}, } @inproceedings{15376, abstract = {Sequential decision-making tasks often require satisfaction of multiple, partially-contradictory objectives. Existing approaches are monolithic, where a single policy fulfills all objectives. We present auction-based scheduling, a decentralized framework for multi-objective sequential decision making. Each objective is fulfilled using a separate and independent policy. Composition of policies is performed at runtime, where at each step, the policies simultaneously bid from pre-allocated budgets for the privilege of choosing the next action. The framework allows policies to be independently created, modified, and replaced. We study path planning problems on finite graphs with two temporal objectives and present algorithms to synthesize policies together with bidding policies in a decentralized manner. We consider three categories of decentralized synthesis problems, parameterized by the assumptions that the policies make on each other. We identify a class of assumptions called assume-admissible for which synthesis is always possible for graphs whose every vertex has at most two outgoing edges.}, author = {Avni, Guy and Mallik, Kaushik and Sadhukhan, Suman}, booktitle = {30th International Conference on Tools and Algorithms for the Construction and Analysis of Systems}, isbn = {9783031572555}, issn = {1611-3349}, location = {Luxembourg City, Luxembourg}, pages = {153--172}, publisher = {Springer Nature}, title = {{Auction-based scheduling}}, doi = {10.1007/978-3-031-57256-2_8}, volume = {14572}, year = {2024}, } @inproceedings{15377, abstract = {We provide an algorithmto solve Rabin and Streett games over graphs with n vertices,m edges, and k colours that runs in ˜O³mn(k!)1+o(1)´time and O(nk logk logn) space, where ˜O hides poly-logarithmic factors. Our algorithm is an improvement by a super quadratic dependence on k! from the currently best known run time of O³mn2(k!)2+o(1)´, obtained by converting a Rabin gameinto a parity game,while simultaneously improving its exponential space requirement. Our main technical ingredient is a characterisation of progress measures for Rabin games using colourful trees and a combinatorial construction of succinctlyrepresented, universal colourful trees. Colourful universal trees are generalisations of universal trees used by Jurdzi´nski and Lazi´c (2017) to solve parity games, as well as of Rabin progress measures of Klarlund and Kozen (1991). Our algorithm for Rabin games is a progress measure lifting algorithm where the lifting is performed on succinct, colourful, universal trees.}, author = {Majumdar, Rupak and Sağlam, Irmak and Thejaswini, K. S.}, booktitle = {30th International Conference on Tools and Algorithms for the Construction and Analysis of Systems}, isbn = {9783031572555}, issn = {1611-3349}, pages = {213--231}, publisher = {Springer Nature}, title = {{Rabin games and colourful universal trees}}, doi = {10.1007/978-3-031-57256-2_11}, volume = {14572}, year = {2024}, } @article{15378, abstract = {We consider N×N non-Hermitian random matrices of the form X+A, where A is a general deterministic matrix and N−−√X consists of independent entries with zero mean, unit variance, and bounded densities. For this ensemble, we prove (i) a Wegner estimate, i.e. that the local density of eigenvalues is bounded by N1+o(1) and (ii) that the expected condition number of any bulk eigenvalue is bounded by N1+o(1); both results are optimal up to the factor No(1). The latter result complements the very recent matching lower bound obtained in [15] (arXiv:2301.03549) and improves the N-dependence of the upper bounds in [5,6,32] (arXiv:1906.11819, arXiv:2005.08930, arXiv:2005.08908). Our main ingredient, a near-optimal lower tail estimate for the small singular values of X+A−z, is of independent interest.}, author = {Erdös, László and Ji, Hong Chang}, issn = {1097-0312}, journal = {Communications on Pure and Applied Mathematics}, number = {9}, pages = {3785--3840}, publisher = {Wiley}, title = {{Wegner estimate and upper bound on the eigenvalue condition number of non-Hermitian random matrices}}, doi = {10.1002/cpa.22201}, volume = {77}, year = {2024}, } @article{15379, abstract = {Long-term potentiation (LTP) of excitatory synapses is a leading model to explain the concept of information storage in the brain. Multiple mechanisms contribute to LTP, but central amongst them is an increased sensitivity of the postsynaptic membrane to neurotransmitter release. This sensitivity is predominantly determined by the abundance and localization of AMPA-type glutamate receptors (AMPARs). A combination of AMPAR structural data, super-resolution imaging of excitatory synapses, and an abundance of electrophysiological studies are providing an ever-clearer picture of how AMPARs are recruited and organized at synaptic junctions. Here, we review the latest insights into this process, and discuss how both cytoplasmic and extracellular receptor elements cooperate to tune the AMPAR response at the hippocampal CA1 synapse.}, author = {Stockwell, Imogen and Watson, Jake and Greger, Ingo H.}, issn = {1521-1878}, journal = {BioEssays}, number = {7}, publisher = {Wiley}, title = {{Tuning synaptic strength by regulation of AMPA glutamate receptor localization}}, doi = {10.1002/bies.202400006}, volume = {46}, year = {2024}, } @article{15380, abstract = {The depth of a cell in an arrangement of n (non-vertical) great-spheres in Sd is the number of great-spheres that pass above the cell. We prove Euler-type relations, which imply extensions of the classic Dehn–Sommerville relations for convex polytopes to sublevel sets of the depth function, and we use the relations to extend the expressions for the number of faces of neighborly polytopes to the number of cells of levels in neighborly arrangements.}, author = {Biswas, Ranita and Cultrera Di Montesano, Sebastiano and Edelsbrunner, Herbert and Saghafian, Morteza}, issn = {2367-1734}, journal = {Journal of Applied and Computational Topology}, pages = {557--578}, publisher = {Springer Nature}, title = {{Depth in arrangements: Dehn–Sommerville–Euler relations with applications}}, doi = {10.1007/s41468-024-00173-w}, volume = {8}, year = {2024}, } @article{15381, abstract = {Cholecystokinin-expressing interneurons (CCKIs) are hypothesized to shape pyramidal cell-firing patterns and regulate network oscillations and related network state transitions. To directly probe their role in the CA1 region, we silenced their activity using optogenetic and chemogenetic tools in mice. Opto-tagged CCKIs revealed a heterogeneous population, and their optogenetic silencing triggered wide disinhibitory network changes affecting both pyramidal cells and other interneurons. CCKI silencing enhanced pyramidal cell burst firing and altered the temporal coding of place cells: theta phase precession was disrupted, whereas sequence reactivation was enhanced. Chemogenetic CCKI silencing did not alter the acquisition of spatial reference memories on the Morris water maze but enhanced the recall of contextual fear memories and enabled selective recall when similar environments were tested. This work suggests the key involvement of CCKIs in the control of place-cell temporal coding and the formation of contextual memories.}, author = {Rangel Guerrero, Dámaris K and Balueva, Kira and Barayeu, Uladzislau and Baracskay, Peter and Gridchyn, Igor and Nardin, Michele and Roth, Chiara N and Wulff, Peer and Csicsvari, Jozsef L}, issn = {1097-4199}, journal = {Neuron}, number = {12}, pages = {2045--2061.e10}, publisher = {Cell Press}, title = {{Hippocampal cholecystokinin-expressing interneurons regulate temporal coding and contextual learning}}, doi = {10.1016/j.neuron.2024.03.019}, volume = {112}, year = {2024}, }