@article{21759, abstract = {Promoters and enhancers are cis-regulatory elements (CREs), DNA sequences that bind transcription factor (TF) proteins to up- or down-regulate target genes. Decades-long efforts yielded TF-DNA interaction models that predict how strongly an individual TF binds arbitrary DNA sequences and how individual binding events on the CRE combine to affect gene expression. These insights can be synthesized into a global, biophysically realistic, and quantitative genotype-phenotype (GP) map for gene regulation, a ‘holy grail’ for the application of evolutionary theory. A global map provides a rare opportunity to simulate the long-term evolution of regulatory sequences and pose several fundamental questions: How long does it take to evolve CREs de novo? How many non-trivial regulatory functions exist in sequence space? How connected are they? For which regulatory architecture is CRE evolution most rapid and evolvable? In this article, the second of a two-part series, we review the application of evolutionary concepts — epistasis, robustness, evolvability, tunability, plasticity, and bet-hedging — to the evolution of gene regulatory sequences. We then evaluate the potential for a unifying theory for the evolution of regulatory sequences and identify key open challenges.}, author = {Mascolo, Elia and Körei, Reka E and Borst, Noa O. and Barton, Nicholas H and Crocker, Justin and Tkačik, Gašper}, issn = {1879-0380}, journal = {Current Opinion in Genetics and Development}, publisher = {Elsevier}, title = {{Long-term evolution of regulatory DNA sequences. Part 2: Theory and future challenges}}, doi = {10.1016/j.gde.2026.102472}, volume = {98}, year = {2026}, } @article{21766, abstract = {We provide a new characterisation of the decades old open problem of extending bilipschitz mappings given on a Euclidean separated net. In particular, this allows for the complete positive solution of the open problem in dimension two. Along the way, we develop a set of tools for bilipschitz extensions of mappings between subsets of Euclidean spaces.}, author = {Dymond, Michael and Kaluza, Vojtech}, issn = {2737-114X}, journal = {Annales Fennici Mathematici}, keywords = {Lipschitz, bilipschitz, extension, separated net.}, number = {1}, pages = {237--260}, publisher = {Finnish Mathematical Society}, title = {{Extending bilipschitz mappings between separated nets}}, doi = {10.54330/afm.181562}, volume = {51}, year = {2026}, } @article{21006, abstract = {Modern experimental methods in programmable self-assembly make it possible to precisely design particle concentrations, shapes and interactions. However, more physical insight is needed before we can take full advantage of this vast design space to assemble nanostructures with complex form and function. Here we show how a substantial part of this design space can be quickly and comprehensively understood by identifying a class of thermodynamic constraints that act on it. These thermodynamic constraints form a high-dimensional convex polyhedron that determines which nanostructures can be assembled at high equilibrium yield and reveals limitations that govern the coexistence of structures. We validate our predictions through detailed, quantitative assembly experiments of nanoscale particles synthesized using DNA origami. Our results uncover physical relationships underpinning many-component programmable self-assembly in equilibrium and form the basis for robust inverse design, applicable to various systems from biological protein complexes to synthetic nanomachines.}, author = {Hübl, Maximilian and Videbæk, Thomas E. and Hayakawa, Daichi and Rogers, W. Benjamin and Goodrich, Carl Peter}, issn = {1745-2481}, journal = {Nature Physics}, publisher = {Springer Nature}, title = {{A polyhedral structure controls programmable self-assembly}}, doi = {10.1038/s41567-025-03120-3}, year = {2026}, } @article{21760, abstract = {3I/ATLAS is the third interstellar object discovered to date, following 1I/‘Oumuamua and 2I/Borisov. Its unusually high excess velocity and active cometary nature make it a key probe of the Galactic population of icy planetesimals. Understanding its origin requires its past trajectory through the Galaxy to be traced and the possible role of stellar encounters to be assessed, both as a potential origin and a perturber to its orbit. We integrated the orbit of 3I/ATLAS backward in time for 10 Myr, together with a sample of Gaia DR3 stars with high-quality astrometry and radial velocities, to identify close passages within 2 pc. We identify 93 nominal encounters, 62 of which are significant at the 2σ level. However, none of these encounters produced any meaningful perturbation. The strongest perturber Gaia DR3 6863591389529611264 at 0.30 pc and with a relative velocity of 35 km s−1, imparted only a velocity change of ∣Δv∣ ≃ 5 × 10−4 km s−1 to the orbit of 3I/ATLAS. Our results indicate that no stellar flybys within the past 10 Myr and 500 pc contained in Gaia DR3 can account for the present trajectory of 3I/ATLAS or be associated with its origin. We further show that 3I/ATLAS is kinematically consistent with a thin-disk population, despite its large peculiar velocity.}, author = {Pérez-Couto, X. and Torres Rodriguez, Santiago and Villaver, E. and Mustill, A. J. and Manteiga, M.}, issn = {1538-4357}, journal = {The Astrophysical Journal}, number = {2}, publisher = {IOP Publishing}, title = {{3I/ATLAS: In search of the witnesses to its voyage}}, doi = {10.3847/1538-4357/ae56ff}, volume = {1001}, year = {2026}, } @article{21761, abstract = {Neural tube closure is a critical morphogenetic process in vertebrate development, and failure to close cranial regions such as the hindbrain neuropore (HNP) leads to severe congenital malformations. While mechanical forces such as actomyosin purse-string contraction and directional cell crawling have been implicated in driving HNP closure, how these forces organize local cell shape and motion to produce large-scale tissue remodeling remains poorly understood. Using live and fixed imaging of mouse embryos combined with cell-based biophysical modeling, we show that these force-generating mechanisms are insufficient to explain the reproducible patterns of cell elongation and nematic alignment observed at the HNP border. Instead, we show that local anisotropic stress and cytoskeletal organization are required to generate these patterns and promote midline cell motion. Our model captures key features of cell shape dynamics and emergent nematic order, which we confirm experimentally, including the alignment of actin fibers with cell shape and enhanced midline cell speed. Comparative analysis with chick embryos, which lack supracellular purse strings, supports a conserved link between tension generation and cellular patterning. These findings establish a physical framework connecting force generation, cell shape anisotropy, and tissue morphodynamics during epithelial gap closure.}, author = {Perez Verdugo, Fernanda L and Maniou, Eirini and Galea, Gabriel L. and Banerjee, Shiladitya}, issn = {1879-0445}, journal = {Current Biology}, number = {8}, pages = {1903--1917.e5}, publisher = {Elsevier}, title = {{Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis}}, doi = {10.1016/j.cub.2026.02.068}, volume = {36}, year = {2026}, } @article{21762, abstract = {Bacteria, like eukaryotes, use conserved cytoskeletal systems for intracellular organization. The plasmid-encoded ParMRC system forms actin-like filaments that segregate low–copy number plasmids. In multicellular cyanobacteria such as Anabaena sp., we found that a chromosomally encoded ParMR system has evolved into a cytoskeletal system named CorMR with a function in cell shape control rather than DNA segregation. Live-cell imaging, in vitro reconstitution, and cryo–electron microscopy revealed that CorM formed dynamically unstable, antiparallel double-stranded filaments that were recruited to the membrane by CorR through an amphipathic helix conserved in multicellular cyanobacteria. CorMR filaments were regulated by MinC, which excluded them from the poles and division plane. Comparative genomics indicated that the repurposing of ParMR and Min systems coevolved with cyanobacterial multicellularity, highlighting the evolutionary plasticity of cytoskeletal systems in bacteria.}, author = {Springstein, Benjamin L and Javoor, Manjunath and Megrian, Daniela and Hajdu, Roman and Hanke, Dustin M. and Zens, Bettina and Weiss, Gregor L. and Schur, Florian Km and Loose, Martin}, issn = {1095-9203}, journal = {Science}, number = {6795}, publisher = {AAAS}, title = {{Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape}}, doi = {10.1126/science.aea6343}, volume = {392}, year = {2026}, } @article{21755, abstract = {Tropical shallow clouds are a major source of uncertainty in Earth's climate sensitivity, especially through their spatial arrangement, which global climate models do not represent. Efforts to understand their organization have partly relied on classifying observed scenes, identifying four patterns as archetypal regimes. Here we analyze geostationary satellite imagery of the western tropical Atlantic using the L‐function, a tool based on point pattern theory that quantifies cloud organization across spatial scales. Classical examples of the four patterns show distinct L‐function fingerprints, revealing their characteristic clustering and regularity scales and aiding physical interpretation. Yet, when evaluating many scenes at fixed spatial scales, the L‐function distribution lacks the distinct modes expected from discrete regimes. This is corroborated by analyses of other organization indices employing diverse approaches, from inter‐cloud nearest‐neighbor distances to fractal analysis. Implications for the parameterization of mesoscale cloud organization in climate models are discussed.}, author = {Biagioli, Giovanni and Mandorli, Giulio and Freischem, Lilli Johanna and Casallas Garcia, Alejandro and Tompkins, Adrian Mark}, issn = {1944-8007}, journal = {Geophysical Research Letters}, number = {8}, publisher = {Wiley}, title = {{Spatial patterns of shallow clouds: Challenging the concept of defined regimes}}, doi = {10.1029/2025gl119921}, volume = {53}, year = {2026}, } @article{21752, abstract = {Epithelial tissues function as multicellular communities that preserve tissue integrity while adapting to diverse environmental stresses by altering cell behaviors. A striking manifestation of such adaptability is cell plasticity, the ability of differentiated cells to revert to stem-like states or adopt alternative fates. Once considered rare and confined to highly regenerative species, cell plasticity is now recognized across the metazoan tree. In early-branching animals such as sponges and cnidarians, transdifferentiation and dedifferentiation are integral to life-cycle transitions and regeneration, whereas in more complex organisms, these processes typically emerge under stress, including stem cell loss or environmental perturbations. Here, we examine epithelial cell plasticity through evolutionary, cellular, and molecular perspectives. Focusing on the intestinal epithelium, we explore findings from mammalian and Drosophila models showing that progenitors and even terminally differentiated cells can dedifferentiate in response to external stimuli that disrupt homeostasis, such as pathogen infection and nutrient fluctuations. We further discuss conserved mechanisms involving intercellular signaling (e.g., Notch, EGFR, and JAK-STAT) and chromatin states primed for reprogramming, modulated by metabolic cues. Together, these insights position cell plasticity as an ancient environmental adaptation strategy, shaped by conserved molecular toolkits and refined by species- and cell lineage-specific innovations.}, author = {Nagai, Hiroki and Nakajima, Yu Ichiro}, issn = {1096-3634}, journal = {Seminars in Cell and Developmental Biology}, publisher = {Elsevier}, title = {{Epithelial cell plasticity in metazoans: Evolutionary insights into roles and mechanisms}}, doi = {10.1016/j.semcdb.2026.103670}, volume = {179-180}, year = {2026}, } @article{21705, abstract = {We report the discovery of ATLAS J101342.5−451656.8 (hereafter ATLAS J1013−4516), an 8.56 minute orbital-period mass-transferring AM Canum Venaticorum (AM CVn) binary with a mean Gaia magnitude of G = 19.51, identified via periodic variability in light curves from the Asteroid Terrestrial-impact Last Alert System (ATLAS) of Gaia white dwarf candidates. Follow-up with the Large Lenslet Array Magellan Spectrograph shows a helium-dominated accretion disk, and high-speed ULTRACAM photometry reveals pronounced primary and secondary eclipses. We construct a decade-long timing baseline leveraging light curves from the ATLAS and Gaia surveys, as well as the high-speed imagers ULTRACAM on the New Energy Telescope and proto-Lightspeed on the Magellan Clay telescope. From this timing baseline, we measure an orbital period derivative of P 1.60 0.07 10 = ± × 12 s s−1. Interpreted in the context of stable mass transfer, the magnitude and sign of P indicate that the orbital evolution is governed by the interplay between gravitationalwave-driven angular-momentum losses and mass transfer, directly probing the donor’s structural response to mass loss. We constrain the accretor and donor mass based on stable mass-transfer arguments assuming angularmomentum loss dominated by gravitational-wave emission, allowing us to infer the characteristic gravitational wave strain of the binary for future space-based GW observatories such as the Laser Interferometer Space Antenna (LISA). We predict a characteristic strain corresponding to a 4 yr LISA signal-to-noise ratio ≳10, establishing ATLAS J1013−4516 as a strong prospective LISA source that will probe long-term orbital evolution in the mass-transferring regime.}, author = {Chickles, Emma T. and Chakraborty, Joheen and Burdge, Kevin B. and Dhillon, Vik S. and Draghis, Paul and El-Badry, Kareem and Green, Matthew J. and Householder, Aaron and Hughes, Sarah and Layden, Christopher and Littlefair, Stuart P. and Munday, James and Pelisoli, Ingrid and Redden, Maya S. and Tonry, John and van Roestel, Joannes C and Angile, Francesco Elio and Brown, Alex J. and Segura, Noel Castro and Dinsmore, Jack and Dyer, Martin and Furesz, Gabor and Gabutti, Michelle and Garbutt, James and García-Mejía, Juliana and Jarvis, Daniel and Kennedy, Mark R. and Kerry, Paul and Mccormac, James and Mo, Geoffrey and Osip, Dave and Parsons, Steven and Pike, Eleanor and Piotrowski, John J. and Romani, Roger W. and Sahman, David and Simcoe, Rob}, issn = {1538-4357}, journal = {The Astrophysical Journal}, number = {2}, publisher = {IOP Publishing}, title = {{An eclipsing 8.56 minutes orbital period mass-transferring binary}}, doi = {10.3847/1538-4357/ae4871}, volume = {1000}, year = {2026}, } @article{21709, abstract = {JWST’s “little red dots” (LRDs) are increasingly interpreted as active galactic nuclei (AGN) obscured by dense thermalized gas rather than dust as evidenced by their X-ray weakness, blackbody-like continua, and Balmer line profiles. Key questions are how LRDs connect to standard UV-luminous AGN, whether transitional phases exist, and whether they are observable. We present the “X-ray dot” (XRD), a compact source at z = 3.28 observed by the NIRSpec Wide Guaranteed Time Observation survey. The XRD exhibits LRD hallmarks: a blackbody-like (Teff ≃ 6400 K) red continuum, a faint but blue rest-UV excess, falling mid-IR emission, and broad Balmer lines (FWHM ∼ 2700–3200 km s−1). Unlike LRDs, however, it is remarkably X-ray luminous (L2−10 keV = 1044.18 erg s−1) and has a continuum inflection that is blueward of the Balmer limit. We find that the red rest-optical and blue mid-IR continuum cannot be reproduced by standard dust-attenuated AGN models without invoking extremely steep extinction curves, nor can the weak mid-IR emission be reconciled with well-established X-ray–torus scaling relations. We therefore consider an alternative scenario: the XRD may be an LRD in transition, where the gas envelope dominates the optical continuum but optically thin sight lines allow X-rays to escape. The XRD may thus provide a physical link between LRDs and standard AGN, offering direct evidence that LRDs are powered by supermassive black holes and providing insight into their accretion properties.}, author = {Hviding, Raphael E. and De Graaff, Anna and Liu, Hanpu and Goulding, Andy D. and Ma, Yilun and Greene, Jenny E. and Boogaard, Leindert A. and Bunker, Andrew J. and Cleri, Nikko J. and Franx, Marijn and Hirschmann, Michaela and Leja, Joel and Matthee, Jorryt J and Naidu, Rohan P. and Setton, David J. and Übler, Hannah and Venturi, Giacomo and Wang, Bingjie}, issn = {2041-8213}, journal = {The Astrophysical Journal Letters}, number = {1}, publisher = {IOP Publishing}, title = {{The X-ray dot: Exotic dust or a late-stage Little Red Dot?}}, doi = {10.3847/2041-8213/ae4c88}, volume = {1000}, year = {2026}, } @article{21704, abstract = {How functional protein sequences are distributed in sequence space is fundamentally important for evolutionary theory and protein design, particularly if a large diversity of protein functions are hidden in evolutionarily unexplored areas of the sequence space. However, this question is understudied in part because experimental and computational studies use extant sequences as a starting point to study sequence space. Here, we study whether extant sequences are representative of the entire functional sequence space. Across thousands of protein families from vertebrates and bacteria we calculate the dimensionality and the volume of sequence space occupied by extant homologs. We find that the observed dimensionality and volume of extant sequence space are minuscule, many orders of magnitude smaller than what we estimated using a model of protein evolution. Simulating sequence evolution we then quantify the impact of phylogeny, selection, and epistasis on restricting the evolutionary exploration of sequence space. We find that sequence evolution from a single common ancestor, or a single point of origin in sequence space, is by far the largest limiting factor that reduces the dimensionality and volume of extant sequence space. These results indicate that there are vast areas of functional sequence space that have not been explored in evolution because of the excessive restrictions on natural exploration of the protein sequence space imposed by the point of origin effect. We suggest that protein design methods that rely on extant sequences may be limited in their ability to discover truly novel functions.}, author = {Isakova, Lada H. and Streltsova, Elizaveta and Bochkareva, Olga and Vlasov, Peter K. and Kondrashov, Fyodor}, issn = {1091-6490}, journal = {Proceedings of the National Academy of Sciences}, number = {14}, pages = {e2532018123}, publisher = {National Academy of Sciences}, title = {{Descent from a common ancestor restricts exploration of protein sequence space}}, doi = {10.1073/pnas.2532018123}, volume = {123}, year = {2026}, } @article{21708, abstract = {On October 4, 2023, a proglacial lake named the South Lhonak lake was the source of a catastrophic Glacier Lake Outburst Flood (GLOF) in the Teesta river basin area, resulting in 24 fatalities and leaving over 70 persons missing. The GLOF also destroyed 13 bridges and a major hydropower plant in the Chungthang region. Over 60,000 individuals in four districts of Sikkim were impacted by this GLOF event. This study examines the factors that led to the GLOF event. Our study shows that the cause of this GLOF was initiated by a landslide, that dumped a substantial amount (~ 38.31 million m3) of debris into the South Lhonak Lake. Furthermore, the glacier that was connected to the lake, lost a big chunk of ice mass (~ 7 million m3) due to calving. The combination of these two processes led to the collapse of the left lateral moraine that consequently generated flood waves which breached the terminal moraine dam of the lake. We recommend monitoring land subsidence and calving events for large proglacial lakes to prevent the disastrous consequences of such GLOFs in the future.}, author = {Mohanty, Litan Kumar and Gantayat, Prateek and Dixit, Ankur and Das Adhikari, Manik and Biswas, Rahul and Singh, Vivek Kumar}, issn = {2045-2322}, journal = {Scientific Reports}, publisher = {Springer Nature}, title = {{Sequence of events that led to the South Lhonak lake outburst flood in Sikkim, India}}, doi = {10.1038/s41598-026-35895-7}, volume = {16}, year = {2026}, } @unpublished{21703, abstract = {Altermagnetism has recently emerged as a distinct class of collinear antiferromagnets that break time-reversal symmetry, exhibiting a host of novel properties. Applied strain has attracted particular attention as a key tuning parameter for altermagnets. Although several experimental studies have demonstrated the preparation of single-domain states through a combination of applied strain and magnetic field, the route to such states remains unclear. Here, we use magneto-optical measurements on single crystals of MnTe under applied strain to show that, in contrast to previous reports, strain acts primarily to rotate the Néel vector L continuously. Since the orientation of L determines the magnetic point group symmetry, this continuous rotation effectively tunes the symmetry and its associated physical properties. Furthermore, we demonstrate that built-in strain in free-standing crystals is sufficient to pin L into continuous textures over millimeter length scales. Together, these results provide guidance for future device design and open the door to leveraging the Néel vector orientation as a tunable degree of freedom in spintronic applications.}, author = {Alex Liebman-Peláez, Alex Liebman-Peláez and Kruppe, Jon and Regmi, Resham Babu and Ghimire, Nirmal J. and Sun, Yue and Mazin, Igor I. and Noad, Hilary M. L. and Analytis, James and Sunko, Veronika and Orenstein, Joseph}, booktitle = {arXiv}, title = {{Strain continuously rotates the Néel vector in altermagnetic MnTe}}, doi = {10.48550/arXiv.2604.07653}, year = {2026}, } @article{21711, abstract = {Background: Low-volume trapping columns are essential for sample enrichment, desalting, and injection profile focusing on nano-LC–MS-based proteomics. They enable higher sample loading, improve chromatographic performance, and protect the analytical column by removing salts and contaminants. Recently, monolithic trap columns with micropillar architecture have emerged as alternatives to conventionally packed traps. This study compares the performance of a packed and a micropillar monolithic trap column for the analysis of tryptic peptides. Methods: A tryptic digest of HeLa cell lysate was analyzed under identical LC–MS conditions using both trap types. Peptides were detected at 214 nm and analyzed by nano-ESI on a Q Exactive Plus Orbitrap. Data were searched against the human UniProt database (February 2023) using FragPipe v20.0, and statistical evaluation of MaxLFQ intensities was performed in Perseus using Welch’s t-test and clustering analysis. Results: Over 2500 proteins were identified with both setups. The packed trap column yielded more total peptides, particularly those with post-translational modifications and higher hydrophilicity, whereas the monolithic column favored peptides of intermediate hydrophobicity. Chromatographic profiles confirmed a slight reduction in the trapping efficiency of hydrophilic peptides by the monolithic trap. Conclusions: Trap column design significantly influences peptide recovery and proteome coverage.}, author = {Miletić Vukajlović, Jadranka and Ilić, Bojana and Bruszel, Bella and Panić-Janković, Tanja and Mitulović, Goran}, issn = {2227-7382}, journal = {Proteomes}, number = {1}, publisher = {MDPI}, title = {{Comparison of the trapping efficiency for tryptic peptides on particle-packed and micro-pillar trap columns for proteomics analyses}}, doi = {10.3390/proteomes14010010}, volume = {14}, year = {2026}, } @article{21712, abstract = {Supermassive black hole binary (SMBHB) systems are expected to form as a consequence of galaxy mergers. At subparsec separations, SMBHBs can be identified as quasars with periodic variability, with previous periodicity searches uncovering significant candidates. However, these searches focused primarily on sinusoidal signals, while theoretical models and hydrodynamical simulations predict that binaries produce more complex non-sinusoidal pulse shapes. Here we examine the efficacy of the Lomb–Scargle periodogram (LSP; one of the most popular tools for periodicity searches in unevenly sampled lightcurves) to detect periodicities with a sawtooth shape mimicking results of hydrodynamical simulations. We simulate idealized well-sampled lightcurves, lightcurves that mimic the data in the Palomar Transient Factory (PTF) analyzed in M. Charisi et al. (2016), and lightcurves that resemble our expectations for single-band data in the upcoming Legacy Survey of Space and Time (LSST) of the Rubin Observatory. We approximate quasar variability with a damped random walk (DRW) model, inject sinusoidal and sawtooth pulse shapes, and assess their statistical significance. We find that in the presence of red noise, the LSP detects a relatively low fraction of the sinusoidal signals (∼45%, ∼24%, and ∼23%, in the PTF-like, idealized, and LSST-like lightcurves, respectively). The fraction is significantly reduced for sawtooth periodicity (with only ∼9% in PTF-like and ∼1% in idealized and LSST-like lightcurves). These low recovery rates imply that previous searches have missed the large majority of binaries. They also have significant implications for the detection of SMBHBs in upcoming LSST necessitating the development of advanced tools that go beyond the simple LSP.}, author = {Lin, Allison and Charisi, Maria and Haiman, Zoltán}, issn = {1538-4357}, journal = {The Astrophysical Journal}, number = {2}, publisher = {IOP Publishing}, title = {{Lomb-scargle periodogram struggles with non-sinusoidal supermassive Black Hole binary signatures in quasar lightcurves}}, doi = {10.3847/1538-4357/ae29a7}, volume = {997}, year = {2026}, } @article{21707, abstract = {Structural and functional differences between brain hemispheres are a common feature of animal nervous systems with reduced bilateral asymmetry often linked to impaired cognitive performance. How neuronal left-right asymmetry is initiated and integrated into a bilaterally symmetrical ground pattern is poorly understood. Here, we show that the directional asymmetry of a Drosophila central brain circuit originates from axonal interactions of two types of bilateral pioneer neurons. Subsequent recruitment of neighboring neurons into the asymmetric neuropil primordium results in hemisphere-specific microcircuits. Circuit lateralization requires dynamic expression of the cell adhesion molecule Fasciclin 2 to maintain structural plasticity in axonal remodeling. Reduced circuit asymmetry following cell type–specific Fasciclin 2 manipulation affects adult brain function. These results reveal an unexpected degree of developmental plasticity of late-born Drosophila neurons in the formation of a circuit node via the lateralized recruitment of symmetric circuit components.}, author = {Markovitsch, Johann W. and Mitić, Daniel and Del Pilar Jiménez García, Alisa and Zane, Alsberga and Kainz, Sarah and Kaur, Rashmit and Hummel, Thomas}, issn = {2375-2548}, journal = {Science Advances}, number = {13}, publisher = {American Association for the Advancement of Science}, title = {{Sequential formation of Drosophila circuit asymmetry via prolonged structural plasticity}}, doi = {10.1126/sciadv.aea6020}, volume = {12}, year = {2026}, } @article{21713, abstract = {GW231123 represents the most massive binary–black hole merger detected to date, lying firmly within, or even above, the pair-instability mass gap. The component spins are both exceptionally high (a1 = 0.90 +0.10/-0.19, a2 = 0.80 +0.20/-0.51), which is difficult to explain with repeated mergers. Here we show that the black hole spin vectors are closely aligned with each other while significantly tilted relative to the binary’s orbital angular momentum, pointing to a common accretion-driven origin. We examine astrophysical formation channels capable of producing near-equal, high-mass, and mutually aligned spins consistent with GW231123—particularly binaries embedded in AGN disks and Population III remnants, which grew via coherent misaligned gas accretion. We further argue that other high-mass, high-spin events, e.g., GW190521, may share a similar evolutionary pathway. These findings underscore the critical role of sustained, coherent accretion in shaping the most extreme black hole binaries.}, author = {Bartos, Imre and Haiman, Zoltán}, issn = {2041-8213}, journal = {The Astrophysical Journal Letters}, number = {2}, publisher = {IOP Publishing}, title = {{Accretion is all you need: Black Hole spin alignment in merger GW231123 indicates accretion pathway}}, doi = {10.3847/2041-8213/ae2bff}, volume = {996}, year = {2026}, } @article{21710, abstract = {Early results from JWST suggest that Epoch of Reionization (EoR) galaxies produce copious ionizing photons, which, if they escape efficiently, could cause reionization to occur too early. We study this problem using JWST imaging and prism spectroscopy for 412 galaxies at 4.5 < z < 9.0. We fit these data simultaneously with stellar population and nebular emission models that include a parameter for the fraction of ionizing photons that escape the galaxy, fesc. We find that the ionization production efficiency, ξion = Q(H0)/LUV, increases with redshift and decreasing UV luminosity, but shows significant scatter, (log ion z, MUV) 0.3 dex. The inferred escape fractions averaged over the population are low, ranging from〈fesc〉 ≃ 2.6% ± 1.4% at 6 < z < 9 to 6.5% ± 2.2% at 4.5 < z < 6, with weak or no indication of evolution with redshift. This implies that in our models most of the ionizing photons need to be absorbed to account for the nebular emission. We compute the impact of our results on reionization, including the distributions for ξion and fesc, and the evolution and uncertainty of the UV luminosity function. Considering galaxies brighter than MUV < −16 mag would produce an intergalactic medium hydrogen-ionized fraction of xe = 0.5 at 5.3 < z < 5.8, possibly too late compared to constraints from from quasistellar object (QSO) sight lines. Including fainter galaxies, MUV < −14 mag, we obtain xe = 0.5 at 6.0 < z < 8.1, fully consistent with QSO and cosmic microwave background data. This implies that EoR galaxies produce plenty of ionizing photons, but that these do not efficiently escape. This may be a result of high gas column densities combined with burstier star formation histories, which limit the time massive stars are able to clear channels through the gas for ionizing photons to escape.}, author = {Papovich, Casey and Cole, Justin W. and Hu, Weida and Finkelstein, Steven L. and Shen, Lu and Arrabal Haro, Pablo and Amorín, Ricardo O. and Backhaus, Bren E. and Bagley, Micaela B. and Bhatawdekar, Rachana and Calabrò, Antonello and Carnall, Adam C. and Cleri, Nikko J. and Daddi, Emanuele and Dickinson, Mark and Grogin, Norman A. and Holwerda, Benne W. and Jaskot, Anne E. and Koekemoer, Anton M. and Llerena, Mario and Lucas, Ray A. and Mascia, Sara and Pacucci, Fabio and Pentericci, Laura and Pérez-González, Pablo G. and Pirzkal, Nor and Raghunathan, Srinivasan and Seillé, Lise Marie and Somerville, Rachel S. and Yung, L. Y.Aaron}, issn = {1538-4357}, journal = {The Astrophysical Journal}, number = {1}, publisher = {IOP Publishing}, title = {{Galaxies in the epoch of reionization are all bark and no bite-plenty of ionizing photons, low escape fractions}}, doi = {10.3847/1538-4357/ae3b25}, volume = {1000}, year = {2026}, } @article{21715, abstract = {New populations of red active galactic nuclei (known as “little red dots”) discovered by JWST exhibit remarkable spectral energy distributions. Leveraging X-ray through far-infrared observations of two of the most luminous known little red dots, we directly measure their bolometric luminosities. We find evidence that more than half of the bolometric luminosity likely emerges in the rest-frame optical, with Lbol/L5100 = 5, roughly half the value for “standard” active galactic nuclei. Meanwhile, the X-ray emitting corona, UV-emitting blackbody, and reprocessed mid to far-infrared emission are all considerably subdominant, assuming that the far-infrared luminosity is well below current measured limits. We present new bolometric corrections that dramatically lower inferred bolometric luminosities by a factor of 10 compared to published values in the literature. These bolometric corrections are in accord with expectations from models in which gas absorption and reprocessing are responsible for the red rest-frame optical colors of little red dots. We discuss how this lowered luminosity scale suggests a lower mass scale for the population by at least an order of magnitude (e.g., ∼105–107 M⊙ black holes, and ∼108 M⊙ galaxies), alleviating tensions with clustering, overmassive black holes, and the integrated black hole mass density in the Universe.}, author = {Greene, Jenny E. and Setton, David J. and Furtak, Lukas J. and Naidu, Rohan P. and Volonteri, Marta and Dayal, Pratika and Labbe, Ivo and Van Dokkum, Pieter and Bezanson, Rachel and Brammer, Gabriel and Cutler, Sam E. and Glazebrook, Karl and De Graaff, Anna and Hirschmann, Michaela and Hviding, Raphael E. and Kokorev, Vasily and Leja, Joel and Liu, Hanpu and Ma, Yilun and Matthee, Jorryt J and Nanayakkara, Themiya and Oesch, Pascal A. and Pan, Richard and Price, Sedona H. and Spilker, Justin S. and Wang, Bingjie and Weaver, John R. and Whitaker, Katherine E. and Williams, Christina C. and Zitrin, Adi}, issn = {1538-4357}, journal = {The Astrophysical Journal}, number = {2}, publisher = {IOP Publishing}, title = {{What you see is what you get: Empirically measured bolometric luminosities of Little Red Dots}}, doi = {10.3847/1538-4357/ae1836}, volume = {996}, year = {2026}, } @article{21716, abstract = {Male germline development in plants is highly sensitive to heat stress, with elevated temperatures frequently impairing male fertility and consequently reducing seed production. Indeed, recent global warming has decreased major crop yields, emphasizing the urgent need to elucidate the molecular and cellular mechanisms underlying heat-induced male sterility. This review synthesizes current knowledge on how heat stress disrupts microsporogenesis and microgametogenesis, and how plants counteract these stresses through diverse thermotolerance mechanisms. We emphasize temperature-sensitive processes, including meiotic progression in male germ cells, programmed cell death of somatic tapetal nurse cells, and post-meiotic pollen tube development. We further discuss how epigenetic regulators enhance thermotolerance by reprogramming DNA methylation landscapes and modulating histone variant distribution. Finally, we propose future directions aimed at understanding the mechanisms of reproductive thermotolerance from the epigenetic perspective.}, author = {Nagai, Hiroki and Feng, Xiaoqi}, issn = {1879-0356}, journal = {Current Opinion in Plant Biology}, number = {6}, publisher = {Elsevier}, title = {{Genetic and epigenetic mechanisms underlying male reproductive thermotolerance}}, doi = {10.1016/j.pbi.2026.102881}, volume = {91}, year = {2026}, }