@unpublished{19063, abstract = {Instruction-tuned Large Language Models (LLMs) show impressive results in numerous practical applications, but they lack essential safety features that are common in other areas of computer science, particularly an explicit separation of instructions and data. This makes them vulnerable to manipulations such as indirect prompt injections and generally unsuitable for safety-critical tasks. Surprisingly, there is currently no established definition or benchmark to quantify this phenomenon. In this work, we close this gap by introducing a formal measure for instruction-data separation and an empirical variant that is calculable from a model's outputs. We also present a new dataset, SEP, that allows estimating the measure for real-world models. Our results on various LLMs show that the problem of instruction-data separation is real: all models fail to achieve high separation, and canonical mitigation techniques, such as prompt engineering and fine-tuning, either fail to substantially improve separation or reduce model utility. The source code and SEP dataset are openly accessible at https://github.com/egozverev/Shold-It-Be-Executed-Or-Processed. }, author = {Zverev, Egor and Abdelnabi, Sahar and Tabesh, Soroush and Fritz, Mario and Lampert, Christoph}, booktitle = {arXiv}, title = {{Can LLMs separate instructions from data? And what do we even mean by that?}}, doi = {10.48550/arXiv.2403.06833}, year = {2024}, } @article{17161, abstract = {Dynamic processes in molecules can occur on a wide range of timescales, and it is important to understand which timescales of motion contribute to different parameters used in dynamics measurements. For spin relaxation, this can easily be understood from the sampling frequencies of the spectral-density function by different relaxation-rate constants. In addition to data from relaxation measurements, determining dynamically averaged anisotropic interactions in magic-angle spinning (MAS) solid-state NMR allows for better quantification of the amplitude of molecular motion. For partially averaged anisotropic interactions, the relevant timescales of motion are not so clearly defined. Whether the averaging depends on the experimental methods (e.g., pulse sequences) or conditions (e.g., MAS frequency, magnitude of anisotropic interaction, radio-frequency field amplitudes) is not fully understood. To investigate these questions, we performed numerical simulations of dynamic systems based on the stochastic Liouville equation using several experiments for recoupling the dipolar coupling, chemical-shift anisotropy or quadrupolar coupling. As described in the literature, the transition between slow motion, where parameters characterizing the anisotropic interaction are not averaged, and fast motion, where the tensors are averaged leading to a scaled anisotropic quantity, occurs over a window of motional rate constants that depends mainly on the strength of the interaction. This transition region can span 2 orders of magnitude in exchange-rate constants (typically in the microsecond range) but depends only marginally on the employed recoupling scheme or sample spinning frequency. The transition region often coincides with a fast relaxation of coherences, making precise quantitative measurements difficult. Residual couplings in off-magic-angle experiments, however, average over longer timescales of motion. While in principle one may gain information on the timescales of motion from the transition area, extracting such information is hampered by low signal-to-noise ratio in experimental spectra due to fast relaxation that occurs in the same region.}, author = {Aebischer, Kathrin and Becker, Lea Marie and Schanda, Paul and Ernst, Matthias}, issn = {2699-0016}, journal = {Magnetic Resonance}, number = {1}, pages = {69--86}, publisher = {Copernicus Publications}, title = {{Evaluating the motional timescales contributing to averaged anisotropic interactions in MAS solid-state NMR}}, doi = {10.5194/mr-5-69-2024}, volume = {5}, year = {2024}, } @misc{22906, author = {Aebischer, Kathrin}, publisher = {Repository}, title = {{Evaluating the motional time scales contributing to averaged anisotropic interactions in MAS solid-state NMR}}, doi = {10.3929/ethz-b-000666765}, year = {2024}, } @article{18603, abstract = {It is widely believed that information storage in neuronal circuits involves nanoscopic structural changes at synapses, resulting in the formation of synaptic engrams. However, direct evidence for this hypothesis is lacking. To test this conjecture, we combined chemical potentiation, functional analysis by paired pre-postsynaptic recordings, and structural analysis by electron microscopy (EM) and freeze-fracture replica labeling (FRL) at the rodent hippocampal mossy fiber synapse, a key synapse in the trisynaptic circuit of the hippocampus. Biophysical analysis of synaptic transmission revealed that forskolin-induced chemical potentiation increased the readily releasable vesicle pool size and vesicular release probability by 146% and 49%, respectively. Structural analysis of mossy fiber synapses by EM and FRL demonstrated an increase in the number of vesicles close to the plasma membrane and the number of clusters of the priming protein Munc13-1, indicating an increase in the number of both docked and primed vesicles. Furthermore, FRL analysis revealed a significant reduction of the distance between Munc13-1 and CaV2.1 Ca2+ channels, suggesting reconfiguration of the channel-vesicle coupling nanotopography. Our results indicate that presynaptic plasticity is associated with structural reorganization of active zones. We propose that changes in potential nanoscopic organization at synaptic vesicle release sites may be correlates of learning and memory at a plastic central synapse.}, author = {Kim, Olena and Okamoto, Yuji and Kaufmann, Walter and Brose, Nils and Shigemoto, Ryuichi and Jonas, Peter M}, issn = {1545-7885}, journal = {PLoS Biology}, number = {11}, publisher = {Public Library of Science}, title = {{Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons}}, doi = {10.1371/journal.pbio.3002879}, volume = {22}, year = {2024}, } @misc{18296, abstract = {It is widely believed that information storage in neuronal circuits involves nanoscopic structural changes at synapses, resulting in the formation of synaptic engrams. However, direct evidence for this hypothesis is lacking. To test this conjecture, we combined chemical potentiation, functional analysis by paired pre-postsynaptic recordings, and structural analysis by electron microscopy (EM) and freeze-fracture replica labeling (FRL) at the murine hippocampal mossy fiber synapse, a key synapse in the trisynaptic circuit of the hippocampus. Biophysical analysis of synaptic transmission revealed that forskolin-induced chemical potentiation increased the readily releasable vesicle pool size and vesicular release probability by 146% and 49%, respectively. Structural analysis of mossy fiber synapses by EM and FRL demonstrated an increase in the number of vesicles close to the plasma membrane and the number of clusters of the priming protein Munc13-1, indicating an increase in the number of both docked and primed vesicles. Furthermore, FRL analysis revealed a significant reduction of the distance between Munc13-1 and CaV2.1 Ca2+ channels, suggesting reconfiguration of the channel-vesicle coupling nanotopography. Our results indicate that presynaptic plasticity is associated with structural reorganization of active zones. We propose that changes in potential nanoscopic organization at synaptic vesicle release sites may be correlates of learning and memory at a plastic central synapse.}, author = {Kim, Olena}, keywords = {Hippocampal mossy fiber synapses, short-term potentiation, long-term potentiation, presynaptic plasticity, electron microscopy, freeze-fracture replica labeling, paired recordings, forskolin, cyclic adenosine monophosphate (cAMP), protein kinase A (PKA), neuromodulation, synaptic vesicle pools, presynaptic Ca2+ channels, Munc13, docking, priming, active zone}, publisher = {Institute of Science and Technology Austria}, title = {{Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons}}, doi = {10.15479/AT:ISTA:18296}, year = {2024}, } @article{18492, abstract = {Surveys in the Milky Way and Large Magellanic Cloud have revealed that the majority of massive stars will interact with companions during their lives. However, knowledge of the binary properties of massive stars at low metallicity, and therefore in conditions approaching those of the Early Universe, remain sparse. We present the Binarity at LOw Metallicity (BLOeM) campaign, an ESO large programme designed to obtain 25 epochs of spectroscopy for 929 massive stars in the Small Magellanic Cloud, allowing us to probe multiplicity in the lowest-metallicity conditions to date (Z = 0.2 Z⊙). BLOeM will provide (i) the binary fraction, (ii) the orbital configurations of systems with periods of P ≲ 3 yr, (iii) dormant black-hole binary candidates (OB+BH), and (iv) a legacy database of physical parameters of massive stars at low metallicity. Main sequence (OB-type) and evolved (OBAF-type) massive stars are observed with the LR02 setup of the GIRAFFE instrument of the Very Large Telescope (3960–4570 Å resolving power R = 6200; typical signal-to-noise ratio(S/N) ≈70–100). This paper utilises the first nine epochs obtained over a three-month time period. We describe the survey and data reduction, perform a spectral classification of the stacked spectra, and construct a Hertzsprung-Russell diagram of the sample via spectral-type and photometric calibrations. Our detailed classification reveals that the sample covers spectral types from O4 to F5, spanning the effective temperature and luminosity ranges 6.5 ≲ Teff/kK ≲ 45 and 3.7 < log L/L⊙ < 6.1 and initial masses of 8 ≲ Mini ≲ 80 M⊙. The sample comprises 159 O-type stars, 331 early B-type (B0–3) dwarfs and giants (luminosity classes V–III), 303 early B-type supergiants (II–I), and 136 late-type BAF supergiants. At least 82 stars are OBe stars: 20 O-type and 62 B-type (13% and 11% of the respective samples). In addition, the sample includes 4 high-mass X-ray binaries, 3 stars resembling luminous blue variables, 2 bloated stripped-star candidates, 2 candidate magnetic stars, and 74 eclipsing binaries.}, author = {Shenar, T. and Bodensteiner, J. and Sana, H. and Crowther, P. A. and Lennon, D. J. and Abdul-Masih, M. and Almeida, L. A. and Backs, F. and Berlanas, S. R. and Bernini-Peron, M. and Bestenlehner, J. M. and Bowman, D. M. and Bronner, V. A. and Britavskiy, N. and De Koter, A. and De Mink, S. E. and Deshmukh, K. and Evans, C. J. and Fabry, M. and Gieles, M. and Gilkis, A. and González-Torà, G. and Gräfener, G. and Götberg, Ylva Louise Linsdotter and Hawcroft, C. and Hénault-Brunet, V. and Herrero, A. and Holgado, G. and Janssens, S. and Johnston, C. and Josiek, J. and Justham, S. and Kalari, V. M. and Katabi, Z. Z. and Keszthelyi, Z. and Klencki, J. and Kubát, J. and Kubátová, B. and Langer, N. and Lefever, R. R. and Ludwig, B. and Mackey, J. and Mahy, L. and Maíz Apellániz, J. and Mandel, I. and Maravelias, G. and Marchant, P. and Menon, A. and Najarro, F. and Oskinova, L. M. and O'Grady, A. J.G. and Ovadia, R. and Patrick, L. R. and Pauli, D. and Pawlak, M. and Ramachandran, V. and Renzo, M. and Rocha, D. F. and Sander, A. A.C. and Sayada, T. and Schneider, F. R.N. and Schootemeijer, A. and Schösser, E. C. and Schürmann, C. and Sen, K. and Shahaf, S. and Simón-Díaz, S. and Stoop, M. and Toonen, S. and Tramper, F. and Van Loon, J. Th and Valli, R. and Van Son, L. A.C. and Vigna-Gómez, A. and Villaseñor, J. I. and Vink, J. S. and Wang, C. and Willcox, R.}, issn = {1432-0746}, journal = {Astronomy & Astrophysics}, publisher = {EDP Sciences}, title = {{Binarity at LOw Metallicity (BLOeM): A spectroscopic VLT monitoring survey of massive stars in the SMC}}, doi = {10.1051/0004-6361/202451586}, volume = {690}, year = {2024}, } @article{14980, abstract = {Precision sensing and manipulation of milligram-scale mechanical oscillators has attracted growing interest in the fields of table-top explorations of gravity and tests of quantum mechanics at macroscopic scales. Torsional oscillators present an opportunity in this regard due to their remarked isolation from environmental noise. For torsional motion, an effective employment of optical cavities to enhance optomechanical interactions—as already established for linear oscillators—so far faced certain challenges. Here, we propose a concept for sensing and manipulating torsional motion, where exclusively the torsional rotations of a pendulum are mapped onto the path length of a single two-mirror optical cavity. The concept inherently alleviates many limitations of previous approaches. A proof-of-principle experiment is conducted with a rigidly controlled pendulum to explore the sensing aspects of the concept and to identify practical limitations in a potential state-of-the art setup. Based on this study, we anticipate development of precision torque sensors utilizing torsional pendulums that can support sensitivities below 10−19Nm/√Hz, while the motion of the pendulums are dominated by quantum radiation pressure noise at sub-microwatts of incoming laser power. These developments will provide horizons for experiments at the interface of quantum mechanics and gravity.}, author = {Agafonova, Sofya and Mishra, Umang and Diorico, Fritz R and Hosten, Onur}, issn = {2643-1564}, journal = {Physical Review Research}, number = {1}, publisher = {American Physical Society}, title = {{Zigzag optical cavity for sensing and controlling torsional motion}}, doi = {10.1103/physrevresearch.6.013141}, volume = {6}, year = {2024}, } @article{18910, abstract = {Proteins often undergo large-scale conformational transitions, in which secondary and tertiary structure elements (loops, helices, and domains) change their structures or their positions with respect to each other. Simple considerations suggest that such dynamics should be relatively fast, but the functional cycles of many proteins are often relatively slow. Sophisticated experimental methods are starting to tackle this dichotomy and shed light on the contribution of large-scale conformational dynamics to protein function. In this review, we focus on the contribution of single-molecule Förster resonance energy transfer and nuclear magnetic resonance (NMR) spectroscopies to the study of conformational dynamics. We briefly describe the state of the art in each of these techniques and then point out their similarities and differences, as well as the relative strengths and weaknesses of each. Several case studies, in which the connection between fast conformational dynamics and slower function has been demonstrated, are then introduced and discussed. These examples include both enzymes and large protein machines, some of which have been studied by both NMR and fluorescence spectroscopies.}, author = {Schanda, Paul and Haran, Gilad}, issn = {1936-1238}, journal = {Annual Review of Biophysics}, pages = {247--273}, publisher = {Annual Reviews}, title = {{NMR and single-molecule FRET insights into fast protein motions and their relation to function}}, doi = {10.1146/annurev-biophys-070323-022428}, volume = {53}, year = {2024}, } @article{15117, abstract = {The hippocampal mossy fiber synapse, formed between axons of dentate gyrus granule cells and dendrites of CA3 pyramidal neurons, is a key synapse in the trisynaptic circuitry of the hippocampus. Because of its comparatively large size, this synapse is accessible to direct presynaptic recording, allowing a rigorous investigation of the biophysical mechanisms of synaptic transmission and plasticity. Furthermore, because of its placement in the very center of the hippocampal memory circuit, this synapse seems to be critically involved in several higher network functions, such as learning, memory, pattern separation, and pattern completion. Recent work based on new technologies in both nanoanatomy and nanophysiology, including presynaptic patch-clamp recording, paired recording, super-resolution light microscopy, and freeze-fracture and “flash-and-freeze” electron microscopy, has provided new insights into the structure, biophysics, and network function of this intriguing synapse. This brings us one step closer to answering a fundamental question in neuroscience: how basic synaptic properties shape higher network computations.}, author = {Vandael, David H and Jonas, Peter M}, issn = {1095-9203}, journal = {Science}, number = {6687}, pages = {eadg6757}, publisher = {AAAS}, title = {{Structure, biophysics, and circuit function of a "giant" cortical presynaptic terminal}}, doi = {10.1126/science.adg6757}, volume = {383}, year = {2024}, } @inbook{18058, abstract = {DNA cloning is a core technique in biomedical and biotechnological research and is used to assemble and modify DNA fragments at will. While DNA cloning has traditionally relied on restriction enzymes, recent homology-based methods offer improved protocols together with seamless and directional assembly of desired products, overcoming the main disadvantages of restriction enzyme DNA cloning. This chapter provides a historical perspective on DNA cloning, presents a detailed discussion on state-of-the-art in vitro and in vivo homology-based methodologies, covering the basics of how to perform all major plasmid modifications (sub-cloning, site-directed mutagenesis, insertions, and deletions), and gives examples of how to apply these techniques for complex DNA cloning projects.}, author = {Watson, Jake and Arroyo-Urea, Sandra and García-Nafría, Javier}, booktitle = {Handbook of Molecular Biotechnology}, editor = {Liu, Dongyou}, pages = {66--72}, publisher = {CRC Press}, title = {{DNA Cloning}}, doi = {10.1201/9781003055211-8}, year = {2024}, } @article{18587, abstract = {Many scientific breakthroughs have depended on animal research, yet the ethical concerns surrounding the use of animals in experimentation have long prompted discussions about humane treatment and responsible scientific practice. First articulated by Russell and Burch, the 3Rs Principles of Replacement, Reduction, and Refinement have gained widespread recognition as basic guidelines for animal research. Over time, the 3Rs have transcended the research community, influencing policy decisions, animal welfare advocacy and public perception of animal experimentation. Despite their broad acceptance, interpretations of the 3Rs vary substantially, shaping statutory frameworks at various levels, with both technical and practical impacts.}, author = {Lauwereyns, Jan and Bajramovic, Jeffrey and Bert, Bettina and Camenzind, Samuel and De Kock, Joery and Elezović, Alisa and Erden, Sevilay and Gonzalez-Uarquin, Fernando and Ulman, Yesim Isil and Hoffmann, Orsolya Ivett and Kitsara, Maria and Kostomitsopoulos, Nikolaos and Neuhaus, Winfried and Petit-Demouliere, Benoit and Pollo, Simone and Riso, Brígida and Schober, Sophie and Sotiropoulos, Athanassia and Thomas, Aurélie and Vitale, Augusto and Wilflingseder, Doris and Ahluwalia, Arti}, issn = {1548-4475}, journal = {Lab Animal}, pages = {347--350}, publisher = {Springer Nature}, title = {{Toward a common interpretation of the 3Rs principles in animal research}}, doi = {10.1038/s41684-024-01476-2}, volume = {53}, year = {2024}, } @article{17409, abstract = {Light-driven rotary molecular motors are among the most promising classes of responsive molecular machines and take advantage of their intrinsic chirality which governs unidirectional rotation. As a consequence of their dynamic function, they receive considerable interest in the areas of supramolecular chemistry, asymmetric catalysis and responsive materials. Among the emerging classes of responsive photochromic molecules, multistate first-generation molecular motors driven by benign visible light remain unexplored, which limits the exploitation of the full potential of these mechanical light-powered systems. Herein, we describe a series of all-visible-light-driven first-generation molecular motors based on the salicylidene Schiff base functionality. Remarkable redshifts up to 100 nm in absorption are achieved compared to conventional first-generation motor structures. Taking advantage of all-visible-light-driven multistate motor scaffolds, adaptive behaviour is found as well, and potential application in multistate photoluminescence is demonstrated. These functional visible-light-responsive motors will likely stimulate the design and synthesis of more sophisticated nanomachinery with a myriad of future applications in powering dynamic systems.}, author = {Van Vliet, Sven and Sheng, Jinyu and Stindt, Charlotte N. and Feringa, Ben L.}, issn = {2041-1723}, journal = {Nature Communications}, publisher = {Springer Nature}, title = {{All-visible-light-driven salicylidene schiff-base-functionalized artificial molecular motors}}, doi = {10.1038/s41467-024-50587-4}, volume = {15}, year = {2024}, } @article{17105, abstract = {The development of photoresponsive systems with non-invasive orthogonal control by distinct wavelengths of light is still in its infancy. In particular, the design of photochemically triggered-orthogonal systems integrated into solid materials that enable multiple dynamic control over their properties remains a longstanding challenge. Here, we report the orthogonal and reversible control of two types of photoswitches in an integrated solid porous framework, that is, visible-light responsive o-fluoroazobenzene and nitro-spiropyran motifs. The properties of the constructed material can be selectively controlled by different wavelengths of light thus generating four distinct states providing a basis for dynamic multifunctional materials. Solid-state NMR spectroscopy demonstrated the selective transformation of the azobenzene switch in the bulk, which in turn modulates N2 and CO2 adsorption.}, author = {Sheng, Jinyu and Perego, Jacopo and Bracco, Silvia and Cieciórski, Piotr and Danowski, Wojciech and Comotti, Angiolina and Feringa, Ben L.}, issn = {1521-3773}, journal = {Angewandte Chemie International Edition}, number = {23}, publisher = {Wiley}, title = {{Orthogonal photoswitching in a porous organic framework}}, doi = {10.1002/anie.202404878}, volume = {63}, year = {2024}, } @article{17054, abstract = {Photoisomerization and photoluminescence are two distinct energy dissipation pathways in light-driven molecular motors. The photoisomerization properties of discrete molecular motors have been well established in solution, but their photoluminescent properties have been rarely reported—especially in aggregates. Here, it is shown that an overcrowded alkene-based molecular motor exhibits distinct dynamic properties in solution and aggregate states, for example, gel and solid states. Despite the poor emissive properties of molecular motors in solution, a bright emission is observed in the aggregate states, including in gel and the crystalline solid. The emission wavelength is highly dependent on the nature of the supramolecular packing and order in the aggregates. As a result, the fluorescent color can be readily tuned reversibly via mechanical grinding and vapor fuming, which provides a new platform for developing multi-stimuli functional materials.}, author = {Shan, Yahan and Sheng, Jinyu and Zhang, Qi and Stuart, Marc C.A. and Qu, Da Hui and Feringa, Ben L.}, issn = {2692-4560}, journal = {Aggregate}, number = {5}, publisher = {Wiley}, title = {{Multi-state photoluminescent properties of an overcrowded alkene-based molecular motor in aggregates}}, doi = {10.1002/agt2.584}, volume = {5}, year = {2024}, } @article{18310, author = {Kitsara, Maria and Smajlhodžić-Deljo, Merima and Gurbeta Pokvic, Lejla and Bert, Bettina and Bubalo, Nataliia and Erden, Sevilay and Franco, Nuno Henrique and Chirico, Giuseppe and Gómez Raja, Jonathan and Gonzalez-Uarquin, Fernando and Lang, Annemarie and Linklater, Nicole and Mojsova, Sandra and Olsson, I. Anna S. and Sandvig, Ioanna and Schaffert, Alexandra and Schmit, Marthe and Schober, Sophie and Sevastre, Bogdan and Wilflingseder, Doris and Ahluwalia, Arti and Neuhaus, Winfried}, issn = {2632-3559}, journal = {Alternatives to Laboratory Animals}, number = {6}, pages = {326--333}, publisher = {SAGE Publications}, title = {{Introducing the COST action ‘Improving the Quality of Biomedical Science with 3Rs Concepts’ (IMPROVE)}}, doi = {10.1177/02611929241286024}, volume = {52}, year = {2024}, } @article{15318, abstract = {We consider a gas of N weakly interacting bosons in the ground state. Such gases exhibit Bose–Einstein condensation. The binding energy is defined as the energy it takes to remove one particle from the gas. In this article, we prove an asymptotic expansion for the binding energy, and compute the first orders explicitly for the homogeneous gas. Our result addresses in particular a conjecture by Nam (Lett Math Phys 108(1):141–159, 2018), and provides an asymptotic expansion of the ionization energy of bosonic atoms.}, author = {Bossmann, Lea and Leopold, Nikolai K and Mitrouskas, David Johannes and Petrat, Sören P}, issn = {1572-9613}, journal = {Journal of Statistical Physics}, number = {4}, publisher = {Springer Nature}, title = {{A note on the binding energy for Bosons in the mean-field limit}}, doi = {10.1007/s10955-024-03260-5}, volume = {191}, year = {2024}, } @article{17478, abstract = {We study the Fröhlich polaron model in R3, and prove a lower bound on its ground state energy as a function of the total momentum. The bound is asymptotically sharp at large coupling. In combination with a corresponding upper bound proved earlier (Mitrouskas et al. in Forum Math. Sigma 11:1–52, 2023), it shows that the energy is approximately parabolic below the continuum threshold, and that the polaron’s effective mass (defined as the semi-latus rectum of the parabola) is given by the celebrated Landau–Pekar formula. In particular, it diverges as α4 for large coupling constant α.}, author = {Brooks, Morris and Seiringer, Robert}, issn = {1618-1913}, journal = {Publications Mathematiques de l'Institut des Hautes Etudes Scientifiques}, pages = {271--309}, publisher = {Springer Nature}, title = {{The Fröhlich polaron at strong coupling: Part II — Energy-momentum relation and effective mass}}, doi = {10.1007/s10240-024-00150-0}, volume = {140}, year = {2024}, } @inbook{18948, abstract = {We consider a gas of N bosons with interactions in the mean-field scaling regime. We review a recent proof of the asymptotic expansion of its spectrum and eigenstates and two applications of this result, namely the derivation of an Edgeworth expansion for fluctuations of one-body operators and the computation of the binding energy of an inhomogeneous Bose gas to any order. Finally, we collect related results for the dynamics of the weakly interacting Bose gas and for the regularized Nelson model.}, author = {Bossmann, Lea and Leopold, Nikolai and Mitrouskas, David Johannes and Petrat, Sören}, booktitle = {Physics and the Nature of Reality}, editor = {Bassi, Angelo and Goldstein, Sheldon and Tumulka, Roderich and Zanghi, Nino}, isbn = {9783031454332}, issn = {2365-6425}, pages = {307--321}, publisher = {Springer Nature}, title = {{Asymptotic Analysis of the Weakly Interacting Bose Gas: A Collection of Recent Results and Applications}}, doi = {10.1007/978-3-031-45434-9_22}, volume = {215}, year = {2024}, } @article{17457, abstract = {Autoantibodies against the protein leucine-rich glioma inactivated 1 (LGI1) cause the most common subtype of autoimmune encephalitis with predominant involvement of the limbic system, associated with seizures and memory deficits. LGI1 and its receptor ADAM22 are part of a transsynaptic protein complex that includes several proteins involved in presynaptic neurotransmitter release and postsynaptic glutamate sensing. Autoantibodies against LGI1 increase excitatory synaptic strength, but studies that genetically disrupt the LGI1-ADAM22 complex report a reduction in postsynaptic glutamate receptor-mediated responses. Thus, the mechanisms underlying the increased synaptic strength induced by LGI1 autoantibodies remain elusive, and the contributions of presynaptic molecules to the LGI1-transsynaptic complex remain unclear. We therefore investigated the presynaptic mechanisms that mediate autoantibody-induced synaptic strengthening.}, author = {Ritzau-Jost, Andreas and Gsell, Felix and Sell, Josefine and Sachs, Stefan and Montanaro-Punzengruber, Jacqueline-Claire and Kirmann, Toni and Maaß, Sebastian and Irani, Sarosh R. and Werner, Christian and Geis, Christian and Sauer, Markus and Shigemoto, Ryuichi and Hallermann, Stefan}, issn = {2332-7812}, journal = {Neurology, Neuroimmunology & Neuroinflammation}, number = {5}, pages = {e200284}, publisher = {Wolters Kluwer}, title = {{LGI1 autoantibodies enhance synaptic transmission by presynaptic Kv1 loss and increased action potential broadening}}, doi = {10.1212/NXI.0000000000200284}, volume = {11}, year = {2024}, } @article{18958, abstract = {This workshop brought together experts on the analysis of quantum many-body problems and quantum statistical mechanics, with the goal of discussing the state-of-the-art of the field, recent developments as well as challenges for the future. The main topics of discussion concerned the equilibrium and dynamical behavior of (bosonic or fermionic) quantum gases, quantum spin systems, as well as quantum field theory models like the Nelson or Fröhlich model.}, author = {Hainzl, Christian and Schlein, Benjamin and Seiringer, Robert and Warzel, Simone}, issn = {1660-8941}, journal = {Oberwolfach Reports}, number = {3}, pages = {2247--2302}, publisher = {EMS Press}, title = {{Many-body quantum systems}}, doi = {10.4171/owr/2023/39}, volume = {20}, year = {2024}, }