@inproceedings{19982, abstract = {Dynamically maintaining the minimum cut in a graph G under edge insertions and deletion is a fundamental problem in dynamic graph algorithms for which no conditional lower bound on the time per operation exists. In an n-node graph the best known (1 + o (1))-approximate algorithm takes update time [14]. If the minimum cut is guaranteed to be (log n )o (1), a deterministic exact algorithm with n o (1) update time exists [8]. We present the first fully dynamic algorithm for (1 + o (1))-approximate minimum cut with n o(1) update time. Our main technical contribution is to show that it suffices to consider small-volume cuts in suitably contracted graphs.}, author = {El-Hayek, Antoine and Henzinger, Monika H and Li, Jason}, booktitle = {Proceedings of the 2025 Annual ACM-SIAM Symposium on Discrete Algorithms}, location = {New Orleans, LA, United States}, pages = {750--784}, publisher = {Society for Industrial and Applied Mathematics}, title = {{Fully dynamic approximate minimum cut in subpolynomial time per operation}}, doi = {10.1137/1.9781611978322.22}, year = {2025}, } @article{19998, abstract = {nspired by Richard Feynman’s 1959 lecture and the 1966 film Fantastic Voyage, the field of micro/nanorobots has evolved from science fiction to reality, with significant advancements in biomedical and environmental applications. Despite the rapid progress, the deployment of functional micro/nanorobots remains limited. This review of the technology roadmap identifies key challenges hindering their widespread use, focusing on propulsion mechanisms, fundamental theoretical aspects, collective behavior, material design, and embodied intelligence. We explore the current state of micro/nanorobot technology, with an emphasis on applications in biomedicine, environmental remediation, analytical sensing, and other industrial technological aspects. Additionally, we analyze issues related to scaling up production, commercialization, and regulatory frameworks that are crucial for transitioning from research to practical applications. We also emphasize the need for interdisciplinary collaboration to address both technical and nontechnical challenges, such as sustainability, ethics, and business considerations. Finally, we propose a roadmap for future research to accelerate the development of micro/nanorobots, positioning them as essential tools for addressing grand challenges and enhancing the quality of life.}, author = {Ju, Xiaohui and Chen, Chuanrui and Oral, Cagatay M. and Sevim, Semih and Golestanian, Ramin and Sun, Mengmeng and Bouzari, Negin and Lin, Xiankun and Urso, Mario and Nam, Jong Seok and Cho, Yujang and Peng, Xia and Landers, Fabian C. and Yang, Shihao and Adibi, Azin and Taz, Nahid and Wittkowski, Raphael and Ahmed, Daniel and Wang, Wei and Magdanz, Veronika and Medina-Sánchez, Mariana and Guix, Maria and Bari, Naimat and Behkam, Bahareh and Kapral, Raymond and Huang, Yaxin and Tang, Jinyao and Wang, Ben and Morozov, Konstantin and Leshansky, Alexander and Abbasi, Sarmad Ahmad and Choi, Hongsoo and Ghosh, Subhadip and Borges Fernandes, Bárbara and Battaglia, Giuseppe and Fischer, Peer and Ghosh, Ambarish and Jurado Sánchez, Beatriz and Escarpa, Alberto and Martinet, Quentin and Palacci, Jérémie A and Lauga, Eric and Moran, Jeffrey and Ramos-Docampo, Miguel A. and Städler, Brigitte and Herrera Restrepo, Ramón Santiago and Yossifon, Gilad and Nicholas, James D. and Ignés-Mullol, Jordi and Puigmartí-Luis, Josep and Liu, Yutong and Zarzar, Lauren D. and Shields, C. Wyatt and Li, Longqiu and Li, Shanshan and Ma, Xing and Gracias, David H. and Velev, Orlin and Sánchez, Samuel and Esplandiu, Maria Jose and Simmchen, Juliane and Lobosco, Antonio and Misra, Sarthak and Wu, Zhiguang and Li, Jinxing and Kuhn, Alexander and Nourhani, Amir and Maric, Tijana and Xiong, Ze and Aghakhani, Amirreza and Mei, Yongfeng and Tu, Yingfeng and Peng, Fei and Diller, Eric and Sakar, Mahmut Selman and Sen, Ayusman and Law, Junhui and Sun, Yu and Pena-Francesch, Abdon and Villa, Katherine and Li, Huaizhi and Fan, Donglei Emma and Liang, Kang and Huang, Tony Jun and Chen, Xiang-Zhong and Tang, Songsong and Zhang, Xueji and Cui, Jizhai and Wang, Hong and Gao, Wei and Kumar Bandari, Vineeth and Schmidt, Oliver G. and Wu, Xianghua and Guan, Jianguo and Sitti, Metin and Nelson, Bradley J. and Pané, Salvador and Zhang, Li and Shahsavan, Hamed and He, Qiang and Kim, Il-Doo and Wang, Joseph and Pumera, Martin}, issn = {1936-086X}, journal = {ACS Nano}, number = {27}, pages = {24174--24334}, publisher = {American Chemical Society}, title = {{Technology roadmap of micro/nanorobots}}, doi = {10.1021/acsnano.5c03911}, volume = {19}, year = {2025}, } @article{20002, abstract = {While the most widely used CRISPR-Cas enzyme is the Cas9 endonuclease from Streptococcus pyogenes (Cas9), it exhibits single-turnover enzyme kinetics which leads to long residence times on product DNA. This blocks access to DNA repair machinery and acts as a major bottleneck during CRISPR-Cas9 gene editing. Cas9 can eventually be removed from the product by extrinsic factors, such as translocating polymerases, but the mechanisms contributing to Cas9 dissociation following cleavage remain poorly understood. Here, we employ truncated guide RNAs as a strategy to weaken PAM-distal nucleic acid interactions and promote faster enzyme turnover. Using kinetics-guided cryo-EM, we examine the conformational landscape of a multi-turnover Cas9, including the first detailed snapshots of Cas9 dissociating from product DNA. We discovered that while the PAM-distal product dissociates from Cas9 following cleavage, tight binding of the PAM-proximal product directly inhibits re-binding of new targets. Our work provides direct evidence as to why Cas9 acts as a single-turnover enzyme and will guide future Cas9 engineering efforts.}, author = {Kiernan, Kaitlyn and Taylor, David W.}, issn = {2041-1723}, journal = {Nature Communications}, publisher = {Springer Nature}, title = {{Visualization of a multi-turnover Cas9 after product release}}, doi = {10.1038/s41467-025-60668-7}, volume = {16}, year = {2025}, } @article{20003, abstract = {The problem of mobile impurities in quantum baths is of fundamental importance in many-body physics. There has recently been significant progress regarding our understanding of this due to cold atom experiments, but so far it has mainly been concerned with cases where the bath has no or only weak interactions, or the impurity interacts weakly with the bath. Here, we address this gap by developing a new theoretical framework for exploring a mobile impurity interacting strongly with a highly correlated bath of bosons in the quantum critical regime of a Mott insulator (MI) to superfluid (SF) quantum phase transition. Our framework is based on a powerful quantum Gutzwiller (QGW) description of the bosonic bath combined with diagrammatic field theory for the impurity-bath interactions. By resumming a selected class of diagrams to infinite order, a rich picture emerges where the impurity is dressed by the fundamental modes of the bath, which change character from gapped particle-hole excitations in the MI to Higgs and gapless Goldstone modes in the SF. This gives rise to the existence of several quasiparticle (polaron) branches with properties reflecting the strongly correlated environment. In particular, one polaron branch exhibits a sharp cusp in its energy, while a new ground-state polaron emerges at the O(2) quantum phase transition point for integer filling, which reflects the nonanalytic behavior at the transition and the appearance of the Goldstone mode in the SF phase. Smooth versions of these features are inherited in the polaron spectrum away from integer filling due to the influence of Mott physics on the bosonic bath. We furthermore compare our diagrammatic results with quantum Monte Carlo calculations, obtaining excellent agreement. This accuracy is quite remarkable for such a highly non-trivial case of strong interactions between the impurity and bosons in a maximally correlated quantum critical regime, and it establishes the utility of our framework. Finally, our results show how impurities can be used as quantum sensors and highlight fundamental differences between experiments performed at a fixed particle number or a fixed chemical potential.}, author = {Al Hyder, Ragheed and Colussi, Victor E. and Čufar, Matija and Brand, Joachim and Recati, Alessio and Bruun, Georg M.}, issn = {2542-4653}, journal = {Scipost Physics}, number = {1}, publisher = {SciPost Foundation}, title = {{Lattice Bose polarons at strong coupling and quantum criticality}}, doi = {10.21468/SciPostPhys.19.1.002}, volume = {19}, year = {2025}, } @inproceedings{20004, abstract = {A long-standing conjecture of Eckhoff, Linhart, and Welzl, which would generalize McMullen’s Upper Bound Theorem for polytopes and refine asymptotic bounds due to Clarkson, asserts that for k ⩽ ⌊(n-d-2)/2⌋, the complexity of the (⩽ k)-level in a simple arrangement of n hemispheres in S^d is maximized for arrangements that are polar duals of neighborly d-polytopes. We prove this conjecture in the case n = d+4. By Gale duality, this implies the following result about crossing numbers: In every spherical arc drawing of K_n in S² (given by a set V ⊂ S² of n unit vectors connected by spherical arcs), the number of crossings is at least 1/4 ⌊n/2⌋ ⌊(n-1)/2⌋ ⌊(n-2)/2⌋ ⌊(n-3)/2⌋. This lower bound is attained if every open linear halfspace contains at least ⌊(n-2)/2⌋ of the vectors in V. Moreover, we determine the space of all linear and affine relations that hold between the face numbers of levels in simple arrangements of n hemispheres in S^d. This completes a long line of research on such relations, answers a question posed by Andrzejak and Welzl in 2003, and generalizes the classical fact that the Dehn-Sommerville relations generate all linear relations between the face numbers of simple polytopes (which correspond to the 0-level). To prove these results, we introduce the notion of the g-matrix, which encodes the face numbers of levels in an arrangement and generalizes the classical g-vector of a polytope.}, author = {Streltsova, Elizaveta and Wagner, Uli}, booktitle = { 41st International Symposium on Computational Geometry}, isbn = {9783959773706}, issn = {1868-8969}, location = {Kanazawa, Japan}, publisher = {Schloss Dagstuhl - Leibniz-Zentrum für Informatik}, title = {{Levels in arrangements: Linear relations, the g-matrix, and applications to crossing numbers}}, doi = {10.4230/LIPIcs.SoCG.2025.75}, volume = {332}, year = {2025}, } @inproceedings{20005, abstract = {We generalize a classical result by Boris Delaunay that introduced Delaunay triangulations. In particular, we prove that for a locally finite and coarsely dense generic point set A in ℝ^d, every generic point of ℝ^d belongs to exactly binom(d+k,d) simplices whose vertices belong to A and whose circumspheres enclose exactly k points of A. We extend this result to the cases in which the points are weighted, and when A contains only finitely many points in ℝ^d or in 𝕊^d. Furthermore, we use the result to give a new geometric proof for the fact that volumes of hypersimplices are Eulerian numbers.}, author = {Edelsbrunner, Herbert and Garber, Alexey and Saghafian, Morteza}, booktitle = {41st International Symposium on Computational Geometry}, isbn = {9783959773706}, issn = {1868-8969}, location = {Kanazawa, Japan}, publisher = {Schloss Dagstuhl - Leibniz-Zentrum für Informatik}, title = {{On spheres with k points inside}}, doi = {10.4230/LIPIcs.SoCG.2025.43}, volume = {332}, year = {2025}, } @inproceedings{20006, abstract = {In numerous fields, dynamic time series data require continuous updates, necessitating efficient data processing techniques for accurate analysis. This paper examines the banana tree data structure, specifically designed to efficiently maintain the multi-scale topological descriptor commonly known as persistent homology for dynamically changing time series data. We implement this data structure and conduct an experimental study to assess its properties and runtime for update operations. Our findings indicate that banana trees are highly effective with unbiased random data, outperforming state-of-the-art static algorithms in these scenarios. Additionally, our results show that real-world time series share structural properties with unbiased random walks, suggesting potential practical utility for our implementation.}, author = {Ost, Lara and Cultrera di Montesano, Sebastiano and Edelsbrunner, Herbert}, booktitle = {41st International Symposium on Computational Geometry}, isbn = {9783959773706}, issn = {1868-8969}, location = {Kanazawa, Japan}, publisher = {Schloss Dagstuhl - Leibniz-Zentrum für Informatik}, title = {{Banana trees for the persistence in time series experimentally}}, doi = {10.4230/LIPIcs.SoCG.2025.71}, volume = {332}, year = {2025}, } @inproceedings{20007, abstract = {There is no known polynomial-time algorithm for graph isomorphism testing, but elementary combinatorial “refinement” algorithms seem to be very efficient in practice. Some philosophical justification for this phenomenon is provided by a classical theorem of Babai, Erdős and Selkow: an extremely simple polynomial-time combinatorial algorithm (variously known as “naïve refinement”, “naïve vertex classification”, “colour refinement” or the “1-dimensional Weisfeiler–Leman algorithm”) yields a so-called canonical labelling scheme for “almost all graphs”. More precisely, for a typical outcome of a random graph G(n,1/2), this simple combinatorial algorithm assigns labels to vertices in a way that easily permits isomorphism-testing against any other graph.}, author = {Anastos, Michael and Kwan, Matthew Alan and Moore, Benjamin}, booktitle = {Proceedings of the 57th Annual ACM Symposium on Theory of Computing}, isbn = {9798400715105}, issn = {0737-8017}, location = {Prague, Czechia}, pages = {2098--2106}, publisher = {Association for Computing Machinery}, title = {{Smoothed analysis for graph isomorphism}}, doi = {10.1145/3717823.3718173}, year = {2025}, } @article{20009, abstract = {The suppression of recombination between young X and Y chromosomes is a crucial step in their evolution, but why it occurs is not known. The detailed characterization of the polymorphic sex chromosomes of the fourspine stickleback by Liu et al. promises to shed new light on this longstanding question.}, author = {Vicoso, Beatriz}, issn = {0169-5347}, journal = {Trends in Ecology and Evolution}, number = {8}, pages = {728--730}, publisher = {Elsevier}, title = {{Sex chromosome evolution in action in fourspine sticklebacks}}, doi = {10.1016/j.tree.2025.06.010}, volume = {40}, year = {2025}, } @article{20010, abstract = {Chirality-induced spin selectivity (CISS), which refers to the ability of chiral molecules to preferentially select spins during electron transfer, has attracted great attention during the past two decades. However, the theoretical and experimental understanding of the CISS effect remains preliminary. In this study, we demonstrate that there is no distinguishable CISS effect in the case of coherent electron transport through single chiral molecular junctions for a set of four molecule studied here. Our conclusion is based on statistical evaluations of thousands of single-molecule junctions across four different molecules with different origins of chirality measured by the scanning tunneling microscope-based break-junction technique. The experimental results for all molecules show no dependence on external magnetic field or chirality in both conductance and current–voltage measurements. In addition, ab initio Hartree-Fork calculations combined with the nonequilibrium Green’s function method reveal that the spin–orbit coupling within chiral junctions bound to a few gold atoms is generally too weak to induce detectable spin polarizations from spin flipping or spin filtering during the ultrafast electron-transport time scale. The absence of an observable CISS effect in the coherent electron-transport regime suggests that the effect may only be found in other electron-transfer regimes and requires further experimental and theoretical efforts to achieve a comprehensive understanding.}, author = {Li, Liang and Shi, Wanzhuo and Mahajan, Ankit and Zhang, Junxiang and Gómez-Gómez, Marta and Labella, Jorge and Louie, Shayan and Torres, Tomás and Barlow, Stephen and Marder, Seth R. and Reichman, David R. and Venkataraman, Latha}, issn = {1520-5126}, journal = {Journal of the American Chemical Society}, number = {28}, pages = {25043--25051}, publisher = {American Chemical Society}, title = {{Too fast for spin flipping: Absence of chirality-induced spin selectivity in coherent electron transport through single-molecule junctions}}, doi = {10.1021/jacs.5c08517}, volume = {147}, year = {2025}, } @article{20011, abstract = {Heat transport in glasses over a wide temperature range is critical for applications in gate dielectrics and thermal insulators but remains poorly understood due to the challenges in modeling vibrational anharmonicity and configurational dynamics across the glass transition. Recent predictions show an unusual decrease in thermal conductivity (κ) with temperature in amorphous hafnia (a-HfO2), contrasting with the typical trend in glasses. Using molecular dynamics with a machine-learning-based neuroevolution potential, we compute κ of a-HfO2 from 50 K to 2000 K. At low temperatures, the Wigner transport equation captures both anharmonicity and quantum statistics. Above 1200 K, atomic diffusion invalidates the quasiparticle picture, and we resort to the Green–Kubo method to capture convective transport. We further extend the Wigner transport equation to supercooled a-HfO2, revealing the crucial role of low-frequency modes in facilitating heat transport. The computed κ, based on both Green–Kubo and Wigner transport theories, increases continuously with temperature up to 2000 K.}, author = {Zeng, Zezhu and Liang, Xia and Fan, Zheyong and Chen, Yue and Simoncelli, Michele and Cheng, Bingqing}, issn = {2639-4979}, journal = {ACS Materials Letters}, pages = {2695--2701}, publisher = {American Chemical Society}, title = {{Thermal transport of amorphous hafnia across the glass transition}}, doi = {10.1021/acsmaterialslett.5c00263}, year = {2025}, } @inproceedings{20024, abstract = {Cooperative software verification divides the task of software verification among several verification tools in order to increase efficiency and effectiveness. The basic approach is to let verifiers work on different parts of a program and at the end join verification results. While this idea is intuitively appealing, cooperative verification is usually hindered by the fact that program decomposition (1) is often static, disregarding strengths and weaknesses of employed verifiers, and (2) often represents the decomposed program parts in a specific proprietary format, thereby making the use of off-the-shelf verifiers in cooperative verification difficult. In this paper, we propose a novel cooperative verification scheme that we call dynamic program splitting (DPS). Splitting decomposes programs into (smaller) programs, and thus directly enables the use of off-the-shelf tools. In DPS, splitting is dynamically applied on demand: Verification starts by giving a verification task (a program plus a correctness specification) to a verifier V1. Whenever V1 finds the current task to be hard to verify, it splits the task (i.e., the program) and restarts verification on subtasks. DPS continues until (1) a violation is found, (2) all subtasks are completed or (3) some user-defined stopping criterion is met. In the latter case, the remaining uncompleted subtasks are merged into a single one and are given to a next verifier V2, repeating the same procedure on the still unverified program parts. This way, the decomposition is steered by what is hard to verify for particular verifiers, leveraging their complementary strengths. We have implemented dynamic program splitting and evaluated it on benchmarks of the annual software verification competition SV-COMP. The evaluation shows that cooperative verification with DPS is able to solve verification tasks that none of the constituent verifiers can solve, without any significant overhead.}, author = {Richter, Cedric and Chalupa, Marek and Jakobs, Marie-Christine and Wehrheim, Heike}, booktitle = {47th International Conference on Software Engineering}, isbn = {9798331505691}, issn = {1558-1225}, location = {Ottawa, ON, Canada}, pages = {2087--2099}, publisher = {IEEE}, title = {{Cooperative software verification via dynamic program splitting}}, doi = {10.1109/ICSE55347.2025.00092}, year = {2025}, } @article{20026, abstract = {Deep Convective Systems (DCSs) reaching scales of 100–1000 km play a pivotal role as the primary precipitation source in the tropics. Those systems can have large cloud shields, and thus not only affect severe precipitation patterns but also play a crucial part in modulating the tropical radiation budget. Understanding the complex factors that control how these systems grow and how they will behave in a warming climate remain fundamental challenges. Research efforts have been directed, on one hand, towards understanding the environmental control on these systems, and on the other hand, towards exploring the internal potential of systems to develop and self-aggregate in idealized simulations. However, we still lack understanding on the relative role of the environment and internal feedbacks on DCS mature size and why. The novel high-resolution global SAM simulation from the DYAMOND project, combined with the TOOCAN Lagrangian tracking of DCSs and machine learning tools, offers an unprecedented opportunity to explore this question. We find that a system’s growth rate during the first 2 h of development predicts its final size with a Pearson correlation coefficient of 0.65. Beyond this period, growth rate emerges as the strongest predictor. However, in the early stages, additional factors–such as ice water path heterogeneity, migration distance, interactions with neighboring systems, and deep shear–play a more significant role. Our study quantitatively assesses the relative influence of internal versus external factors on the mature cloud shield size. Our results show that system-intrinsic properties exert a stronger influence than environmental conditions, suggesting that the initial environment does not strictly constrain final system size, particularly for larger systems where internal dynamics dominate.}, author = {Abramian, Sophie and Muller, Caroline J and Risi, Camille and Fiolleau, Thomas and Roca, Rémy}, issn = {2397-3722}, journal = {npj Climate and Atmospheric Science}, publisher = {Springer Nature}, title = {{How key features of early development shape deep convective systems}}, doi = {10.1038/s41612-025-01154-1}, volume = {8}, year = {2025}, } @article{20027, abstract = {We present the first results of the JWST Emission Line Survey (JELS). Utilizing the first NIRCam narrow-band imaging at 4.7 μm, over 63 arcmin2 in the PRIMER/COSMOS field, we have identified 609 emission line galaxy candidates. From these, we robustly selected 35 H α star-forming galaxies at z ∼ 6.1, with H α star-formation rates (SFRH α) of ∼ 0.9 − 15 M yr−1. Combining our unique H α sample with the exquisite panchromatic data in the field, we explored their physical properties and star-formation histories, and compared these to a broad-band selected sample at z ∼ 6 which has offered vital new insights into the nature of high-redshift galaxies. UV-continuum slopes (β) were considerably redder for our H α sample (β ∼ −1.92) compared to the broad-band sample (β ∼ −2.35). This was not due to dust attenuation as our H α sample was relatively dustpoor (median AV = 0.23); instead, we argue that the reddened slopes could be due to nebular continuum. We compared SFRH α and the UV-continuum-derived SFRUV to SED-fitted measurements averaged over canonical time-scales of 10 and 100 Myr (SFR10 and SFR100). We found an increase in recent SFR for our sample of H α emitters, particularly at lower stellar masses (< 109 M). We also found that SFRH α strongly traces SFR averaged over 10 Myr time-scales, whereas the UV-continuum overpredicts SFR on 100 Myr time-scales at low stellar masses. These results point to our H α sample undergoing ‘bursty’ star formation. Our F356W z ∼ 6 sample showed a larger scatter in SFR10/SFR100 across all stellar masses, which has highlighted how narrow-band photometric selections of H α emitters are key to quantifying the burstiness of star-formation activity. }, author = {Pirie, C. A. and Best, P. N. and Duncan, K. J. and Mcleod, D. J. and Cochrane, R. K. and Clausen, M. and Dunlop, J. S. and Flury, S. R. and Geach, J. E. and Hale, C. L. and Ibar, E. and Kondapally, R. and Li, Zefeng and Matthee, Jorryt J and Mclure, R. J. and Ossa-Fuentes, L. and Patrick, A. L. and Smail, Ian and Sobral, D. and Stephenson, H. M.O. and Stott, J. P. and Swinbank, A. M.}, issn = {1365-2966}, journal = {Monthly Notices of the Royal Astronomical Society}, number = {2}, pages = {1348--1376}, publisher = {Oxford University Press}, title = {{The JWST Emission Line Survey (JELS): An untargeted search for H α emission line galaxies at z > 6 and their physical properties}}, doi = {10.1093/mnras/staf1006}, volume = {541}, year = {2025}, } @article{20028, abstract = {We present the JWST Emission-Line Survey (JELS), a JWST imaging programme exploiting the wavelength coverage and sensitivity of the Near-Infrared Camera (NIRCam) to extend narrow-band rest-optical emission-line selection into the Epoch of Reionization (EoR) for the first time, and to enable unique studies of the resolved ionized gas morphology in individual galaxies across cosmic history. The primary JELS observations comprise ∼ 4.7 μm narrow-band imaging over ∼ 63 arcmin2 designed to enable selection of H α emitters at z ∼ 6.1 and a host of novel emission-line samples, including [O III] (z ∼ 8.3) and Paschen α/β (z ∼ 1.5/2.8). For the F466N/F470N narrow-band observations, the emission-line sensitivities achieved are up to ∼ 2× more sensitive than current slitless spectroscopy surveys (5σ limits of 0.8–1.2×10−18 erg s−1cm−2), corresponding to unobscured H α star formation rates (SFRs) of 0.9–1.3 M yr−1 at z ∼ 6.1, extending emission-line selections in the EoR to fainter populations. Simultaneously, JELS also adds F200W broad-band and F212N narrow-band imaging (H α at z ∼ 2.23) that probes SFRs 5× fainter than previous ground-based narrow-band studies (∼ 0.2 M yr−1), offering an unprecedented resolved view of star formation at cosmic noon. We present the detailed JELS design, key data processing steps specific to the survey observations, and demonstrate the exceptional data quality and imaging sensitivity achieved. We then summarize the key scientific goals of JELS, demonstrate the precision and accuracy of the expected redshift and measured emission-line recovery through detailed simulations, and present examples of spectroscopically confirmed H α and [O III] emitters discovered by JELS that illustrate the novel parameter space probed.}, author = {Duncan, K. J. and Mcleod, D. J. and Best, P. N. and Pirie, C. A. and Clausen, M. and Cochrane, R. K. and Dunlop, J. S. and Flury, S. R. and Geach, J. E. and Grogin, N. A. and Hale, C. L. and Ibar, E. and Kondapally, R. and Li, Zefeng and Matthee, Jorryt J and Mclure, R. J. and Ossa-Fuentes, Luis and Patrick, A. L. and Smail, Ian and Sobral, D. and Stephenson, H. M.O. and Stott, J. P. and Swinbank, A. M.}, issn = {1365-2966}, journal = {Monthly Notices of the Royal Astronomical Society}, number = {2}, pages = {1329--1347}, publisher = {Oxford University Press}, title = {{The JWST Emission-Line Survey: Extending rest-optical narrow-band emission-line selection into the Epoch of Reionization}}, doi = {10.1093/mnras/staf1061}, volume = {541}, year = {2025}, } @article{20029, abstract = {Vacuolar acidification is crucial for the homeostasis of intracellular pH and the recycling of proteins and nutrients in cells, thereby playing important roles in various physiological processes related to vacuolar function. The key factors regulating vacuolar acidification and underlying mechanisms remain unclear. Here, we report that Arabidopsis phospholipase Dζ2 (PLDζ2) promotes the acidification of the vacuolar lumen to stimulate autophagic degradation under phosphorus deficiency. The pldζ2 mutant massively accumulates autophagic structures while exhibiting premature leaf senescence under nutrient starvation. Impaired autophagic flux, lytic vacuole morphology, and lytic degradation in pldζ2 indicate that PLDζ2 regulates autophagy by affecting the vacuolar function. PLDζ2 locates in both tonoplast and cytoplasm. Genetic, structural, and biochemical studies demonstrate that PLDζ2 directly interacts with vacuolar-type ATPase (V-ATPase) subunit D (VATD) to promote vacuolar acidification and autophagy under phosphorus starvation. These findings reveal the importance of V-ATPase and vacuolar pH in autophagic activity and provide clues in elucidating the regulatory mechanism of vacuolar acidification.}, author = {Guan, Bin and Xie, Ke Xuan and Du, Xin Qiao and Bai, Yu Xuan and Hao, Peng Chao and Lin, Wen Hui and Friml, Jiří and Xue, Hong Wei}, issn = {2211-1247}, journal = {Cell Reports}, number = {7}, publisher = {Elsevier}, title = {{Arabidopsis phospholipase Dζ2 facilitates vacuolar acidification and autophagy under phosphorus starvation by interacting with VATD}}, doi = {10.1016/j.celrep.2025.116024}, volume = {44}, year = {2025}, } @article{20030, abstract = {We report the discovery of a Lyα emitter (LAE) candidate in the immediate foreground of the quasar PSO J158-14 at zQSO = 6.0685 at a projected distance ∼29 pkpc that is associated with an extremely metal-poor absorption system. This system was found in archival observations of the quasar field with the Very Large Telescope (VLT)/Multi-Unit Spectroscopic Explorer (MUSE) and was previously missed in searches of absorption systems using quasar absorption line spectroscopy, as it imparts no detectable metal absorption lines on the background quasar spectrum. The detected Lyα emission line at a redshift of zLAE = 6.0323 is well aligned with the outer edge of the quasar’s proximity zone and can plausibly cause its observed damping wing if it is associated with a proximate subdamped Lyα absorption system with a column density of log Nhi/cm^-2 19.7. A >10 hr medium-resolution spectrum of the quasar observed with the Magellan/Folded-port InfraRed Echellette (FIRE) and VLT/X-Shooter spectrographs reveals a metallicity constraint of [Z/H] < −3. Such low metallicity makes this system an extremely metal-poor galaxy candidate and provides an exciting site to study possible signatures of Population III stars.}, author = {Ďurovčíková, Dominika and Eilers, Anna Christina and Simcoe, Robert A. and Welsh, Louise and Meyer, Romain A. and Matthee, Jorryt J and Ryan-Weber, Emma V. and Yue, Minghao and Katz, Harley and Satyavolu, Sindhu and Becker, George and Davies, Frederick B. and Farina, Emanuele Paolo}, issn = {2041-8213}, journal = {The Astrophysical Journal Letters}, number = {2}, publisher = {IOP Publishing}, title = {{An extremely metal-poor Lyα emitter candidate at z = 6 revealed through absorption spectroscopy}}, doi = {10.3847/2041-8213/ade71c}, volume = {987}, year = {2025}, } @article{20031, abstract = {The central vacuole is a multifunctional organelle with the most significant occupancy in a differentiated plant cell. Plants depend on the function of the vacuole for critical development, growth, and environmental responses. As the cell expands, the vacuole changes shape and size, increasing its membrane and luminal content. The set of these events is called the vacuolar configuration process, which has not been well described. Our research highlights the impact of plasma membrane internalization on vacuole morphology during the vacuolar configuration process. We observed a direct correlation between differential endocytosis rates and the enrichment of vacuolar membranous structures. Chemical and genetic interference with clathrin-mediated endocytosis (CME) revealed that it is required for the vacuolar configuration of growing root cells. The contribution of CME to the vacuole configuration process co-occurs with the induction of post-trans-Golgi network (TGN)/early endosome (EE) trafficking with the participation of the Rab GTPases ARA6 and ARA7. Our results show that the CME plays an active role during vacuole configuration, most probably carrying the material that allows the establishment of the vacuole in elongating cells. Since membrane trafficking through the EE/TGN is required to reach the vacuole, additional players must be defined.}, author = {Osorio-Navarro, Claudio and Neira-Valenzuela, Gabriel and Sierra, Paula and Adamowski, Maciek and Toledo, Jorge and Norambuena, Lorena}, issn = {1460-2431}, journal = {Journal of Experimental Botany}, number = {10}, pages = {2700--2714}, publisher = {Oxford University Press}, title = {{The configuration of the vacuole is driven by clathrin-mediated trafficking in root cells of Arabidopsis thaliana}}, doi = {10.1093/jxb/eraf084}, volume = {76}, year = {2025}, } @inproceedings{20032, abstract = {We propose Scalable Mechanistic Neural Network (S-MNN), an enhanced neural network framework designed for scientific machine learning applications involving long temporal sequences. By reformulating the original Mechanistic Neural Network (MNN) (Pervez et al., 2024), we reduce the computational time and space complexities from cubic and quadratic with respect to the sequence length, respectively, to linear. This significant improvement enables efficient modeling of long-term dynamics without sacrificing accuracy or interpretability. Extensive experiments demonstrate that S-MNN matches the original MNN in precision while substantially reducing computational resources. Consequently, S-MNN can drop-in replace the original MNN in applications, providing a practical and efficient tool for integrating mechanistic bottlenecks into neural network models of complex dynamical systems. Source code is available at https://github.com/IST-DASLab/ScalableMNN.}, author = {Chen, Jiale and Yao, Dingling and Pervez, Adeel A and Alistarh, Dan-Adrian and Locatello, Francesco}, booktitle = {13th International Conference on Learning Representations}, isbn = {9798331320850}, location = {Singapore, Singapore}, pages = {63716--63737}, publisher = {ICLR}, title = {{Scalable mechanistic neural networks}}, year = {2025}, } @inproceedings{20033, abstract = {A growing number of machine learning scenarios rely on knowledge distillation where one uses the output of a surrogate model as labels to supervise the training of a target model. In this work, we provide a sharp characterization of this process for ridgeless, high-dimensional regression, under two settings: (i) model shift, where the surrogate model is arbitrary, and (ii) distribution shift, where the surrogate model is the solution of empirical risk minimization with out-of-distribution data. In both cases, we characterize the precise risk of the target model through non-asymptotic bounds in terms of sample size and data distribution under mild conditions. As a consequence, we identify the form of the optimal surrogate model, which reveals the benefits and limitations of discarding weak features in a data-dependent fashion. In the context of weak-to-strong (W2S) generalization, this has the interpretation that (i) W2S training, with the surrogate as the weak model, can provably outperform training with strong labels under the same data budget, but (ii) it is unable to improve the data scaling law. We validate our results on numerical experiments both on ridgeless regression and on neural network architectures.}, author = {Emrullah Ildiz, M. and Gozeten, Halil Alperen and Taga, Ege Onur and Mondelli, Marco and Oymak, Samet}, booktitle = {13th International Conference on Learning Representations}, isbn = {9798331320850}, location = {Singapore, Singapore}, pages = {2967--3006}, publisher = {ICLR}, title = {{High-dimensional analysis of knowledge distillation: Weak-to-Strong generalization and scaling laws}}, year = {2025}, }