@article{12148, abstract = {We prove a general local law for Wigner matrices that optimally handles observables of arbitrary rank and thus unifies the well-known averaged and isotropic local laws. As an application, we prove a central limit theorem in quantum unique ergodicity (QUE): that is, we show that the quadratic forms of a general deterministic matrix A on the bulk eigenvectors of a Wigner matrix have approximately Gaussian fluctuation. For the bulk spectrum, we thus generalise our previous result [17] as valid for test matrices A of large rank as well as the result of Benigni and Lopatto [7] as valid for specific small-rank observables.}, author = {Cipolloni, Giorgio and Erdös, László and Schröder, Dominik J}, issn = {2050-5094}, journal = {Forum of Mathematics, Sigma}, keywords = {Computational Mathematics, Discrete Mathematics and Combinatorics, Geometry and Topology, Mathematical Physics, Statistics and Probability, Algebra and Number Theory, Theoretical Computer Science, Analysis}, publisher = {Cambridge University Press}, title = {{Rank-uniform local law for Wigner matrices}}, doi = {10.1017/fms.2022.86}, volume = {10}, year = {2022}, } @article{12149, abstract = {Editorial on the Research Topic}, author = {Gambino, Giuditta and Bhik-Ghanie, Rebecca and Giglia, Giuseppe and Puig, M. Victoria and Ramirez Villegas, Juan F and Zaldivar, Daniel}, issn = {1662-5110}, journal = {Frontiers in Neural Circuits}, keywords = {Cellular and Molecular Neuroscience, Cognitive Neuroscience, Sensory Systems, Neuroscience (miscellaneous)}, publisher = {Frontiers Media}, title = {{Editorial: Neuromodulatory ascending systems: Their influence at the microscopic and macroscopic levels}}, doi = {10.3389/fncir.2022.1028154}, volume = {16}, year = {2022}, } @article{12150, abstract = {Methods inspired from machine learning have recently attracted great interest in the computational study of quantum many-particle systems. So far, however, it has proven challenging to deal with microscopic models in which the total number of particles is not conserved. To address this issue, we propose a variant of neural network states, which we term neural coherent states. Taking the Fröhlich impurity model as a case study, we show that neural coherent states can learn the ground state of nonadditive systems very well. In particular, we recover exact diagonalization in all regimes tested and observe substantial improvement over the standard coherent state estimates in the most challenging intermediate-coupling regime. Our approach is generic and does not assume specific details of the system, suggesting wide applications.}, author = {Rzadkowski, Wojciech and Lemeshko, Mikhail and Mentink, Johan H.}, issn = {2469-9969}, journal = {Physical Review B}, number = {15}, publisher = {American Physical Society}, title = {{Artificial neural network states for nonadditive systems}}, doi = {10.1103/physrevb.106.155127}, volume = {106}, year = {2022}, } @article{12151, abstract = {The k-sample G(k,W) from a graphon W:[0,1]2→[0,1] is the random graph on {1,…,k}, where we sample x1,…,xk∈[0,1] uniformly at random and make each pair {i,j}⊆{1,…,k} an edge with probability W(xi,xj), with all these choices being mutually independent. Let the random variable Xk(W) be the number of edges in G(k,W). Vera T. Sós asked in 2012 whether two graphons U, W are necessarily weakly isomorphic if the random variables Xk(U) and Xk(W) have the same distribution for every integer k≥2. This question when one of the graphons W is a constant function was answered positively by Endre Csóka and independently by Jacob Fox, Tomasz Łuczak and Vera T. Sós. Here we investigate the question when W is a 2-step graphon and prove that the answer is positive for a 3-dimensional family of such graphons. We also present some related results.}, author = {Cooley, Oliver and Kang, M. and Pikhurko, O.}, issn = {1588-2632}, journal = {Acta Mathematica Hungarica}, keywords = {graphon, k-sample, graphon forcing, graph container}, pages = {1--26}, publisher = {Springer Nature}, title = {{On a question of Vera T. Sós about size forcing of graphons}}, doi = {10.1007/s10474-022-01265-8}, volume = {168}, year = {2022}, } @article{12152, abstract = {ESCRT-III filaments are composite cytoskeletal polymers that can constrict and cut cell membranes from the inside of the membrane neck. Membrane-bound ESCRT-III filaments undergo a series of dramatic composition and geometry changes in the presence of an ATP-consuming Vps4 enzyme, which causes stepwise changes in the membrane morphology. We set out to understand the physical mechanisms involved in translating the changes in ESCRT-III polymer composition into membrane deformation. We have built a coarse-grained model in which ESCRT-III polymers of different geometries and mechanical properties are allowed to copolymerise and bind to a deformable membrane. By modelling ATP-driven stepwise depolymerisation of specific polymers, we identify mechanical regimes in which changes in filament composition trigger the associated membrane transition from a flat to a buckled state, and then to a tubule state that eventually undergoes scission to release a small cargo-loaded vesicle. We then characterise how the location and kinetics of polymer loss affects the extent of membrane deformation and the efficiency of membrane neck scission. Our results identify the near-minimal mechanical conditions for the operation of shape-shifting composite polymers that sever membrane necks.}, author = {Jiang, Xiuyun and Harker-Kirschneck, Lena and Vanhille-Campos, Christian Eduardo and Pfitzner, Anna-Katharina and Lominadze, Elene and Roux, Aurélien and Baum, Buzz and Šarić, Anđela}, issn = {1553-7358}, journal = {PLOS Computational Biology}, keywords = {Computational Theory and Mathematics, Cellular and Molecular Neuroscience, Genetics, Molecular Biology, Ecology, Modeling and Simulation, Ecology, Evolution, Behavior and Systematics}, number = {10}, publisher = {Public Library of Science}, title = {{Modelling membrane reshaping by staged polymerization of ESCRT-III filaments}}, doi = {10.1371/journal.pcbi.1010586}, volume = {18}, year = {2022}, } @article{12154, abstract = {We review our theoretical results of the sound propagation in two-dimensional (2D) systems of ultracold fermionic and bosonic atoms. In the superfluid phase, characterized by the spontaneous symmetry breaking of the U(1) symmetry, there is the coexistence of first and second sound. In the case of weakly-interacting repulsive bosons, we model the recent measurements of the sound velocities of 39K atoms in 2D obtained in the weakly-interacting regime and around the Berezinskii–Kosterlitz–Thouless (BKT) superfluid-to-normal transition temperature. In particular, we perform a quite accurate computation of the superfluid density and show that it is reasonably consistent with the experimental results. For superfluid attractive fermions, we calculate the first and second sound velocities across the whole BCS-BEC crossover. In the low-temperature regime, we reproduce the recent measurements of first-sound speed with 6Li atoms. We also predict that there is mixing between sound modes only in the finite-temperature BEC regime.}, author = {Salasnich, Luca and Cappellaro, Alberto and Furutani, Koichiro and Tononi, Andrea and Bighin, Giacomo}, issn = {2073-8994}, journal = {Symmetry}, keywords = {Physics and Astronomy (miscellaneous), General Mathematics, Chemistry (miscellaneous), Computer Science (miscellaneous)}, number = {10}, publisher = {MDPI}, title = {{First and second sound in two-dimensional bosonic and fermionic superfluids}}, doi = {10.3390/sym14102182}, volume = {14}, year = {2022}, } @article{12155, abstract = {The growing demand of thermal management in various fields such as miniaturized 5G chips has motivated researchers to develop new and high-performance solid-state refrigeration technologies, typically including multicaloric and thermoelectric (TE) cooling. Among them, TE cooling has attracted huge attention owing to its advantages of rapid response, large cooling temperature difference, high stability, and tunable device size. Bi2Te3-based alloys have long been the only commercialized TE cooling materials, while novel systems SnSe and Mg3(Bi,Sb)2 have recently been discovered as potential candidates. However, challenges and problems still require to be summarized and further resolved for realizing better cooling performance. In this review, we systematically investigate TE cooling from its internal mechanism, crucial parameters, to device design and applications. Furthermore, we summarize the current optimization strategies for existing TE cooling materials, and finally provide some personal prospects especially the material-planification concept on future research on establishing better TE cooling.}, author = {Qin, Yongxin and Qin, Bingchao and Wang, Dongyang and Chang, Cheng and Zhao, Li-Dong}, issn = {1754-5706}, journal = {Energy & Environmental Science}, keywords = {Pollution, Nuclear Energy and Engineering, Renewable Energy, Sustainability and the Environment, Environmental Chemistry}, number = {11}, pages = {4527--4541}, publisher = {Royal Society of Chemistry}, title = {{Solid-state cooling: Thermoelectrics}}, doi = {10.1039/d2ee02408j}, volume = {15}, year = {2022}, } @article{12156, abstract = {Models of transcriptional regulation that assume equilibrium binding of transcription factors have been less successful at predicting gene expression from sequence in eukaryotes than in bacteria. This could be due to the non-equilibrium nature of eukaryotic regulation. Unfortunately, the space of possible non-equilibrium mechanisms is vast and predominantly uninteresting. The key question is therefore how this space can be navigated efficiently, to focus on mechanisms and models that are biologically relevant. In this review, we advocate for the normative role of theory—theory that prescribes rather than just describes—in providing such a focus. Theory should expand its remit beyond inferring mechanistic models from data, towards identifying non-equilibrium gene regulatory schemes that may have been evolutionarily selected, despite their energy consumption, because they are precise, reliable, fast, or otherwise outperform regulation at equilibrium. We illustrate our reasoning by toy examples for which we provide simulation code.}, author = {Zoller, Benjamin and Gregor, Thomas and Tkačik, Gašper}, issn = {2452-3100}, journal = {Current Opinion in Systems Biology}, keywords = {Applied Mathematics, Computer Science Applications, Drug Discovery, General Biochemistry, Genetics and Molecular Biology, Modeling and Simulation}, number = {9}, publisher = {Elsevier}, title = {{Eukaryotic gene regulation at equilibrium, or non?}}, doi = {10.1016/j.coisb.2022.100435}, volume = {31}, year = {2022}, } @article{12157, abstract = {Polygenic adaptation is thought to be ubiquitous, yet remains poorly understood. Here, we model this process analytically, in the plausible setting of a highly polygenic, quantitative trait that experiences a sudden shift in the fitness optimum. We show how the mean phenotype changes over time, depending on the effect sizes of loci that contribute to variance in the trait, and characterize the allele dynamics at these loci. Notably, we describe the two phases of the allele dynamics: The first is a rapid phase, in which directional selection introduces small frequency differences between alleles whose effects are aligned with or opposed to the shift, ultimately leading to small differences in their probability of fixation during a second, longer phase, governed by stabilizing selection. As we discuss, key results should hold in more general settings and have important implications for efforts to identify the genetic basis of adaptation in humans and other species.}, author = {Hayward, Laura and Sella, Guy}, issn = {2050-084X}, journal = {eLife}, keywords = {General Immunology and Microbiology, General Biochemistry, Genetics and Molecular Biology, General Medicine, General Neuroscience}, publisher = {eLife Sciences Publications}, title = {{Polygenic adaptation after a sudden change in environment}}, doi = {10.7554/elife.66697}, volume = {11}, year = {2022}, } @inproceedings{12160, abstract = {We present the Filecoin Hierarchical Consensus framework, which aims to overcome the throughput challenges of blockchain consensus by horizontally scaling the network. Unlike traditional sharding designs, based on partitioning the state of the network, our solution centers on the concept of subnets -which are organized hierarchically- and can be spawned on-demand to manage new state. Child sub nets are firewalled from parent subnets, have their own specific policies, and run a different consensus algorithm, increasing the network capacity and enabling new applications. Moreover, they benefit from the security of parent subnets by periodically checkpointing state. In this paper, we introduce the overall system architecture, our detailed designs for cross-net transaction handling, and the open questions that we are still exploring.}, author = {De la Rocha, Alfonso and Kokoris Kogias, Eleftherios and Soares, Jorge M. and Vukolic, Marko}, booktitle = {42nd International Conference on Distributed Computing Systems Workshops}, issn = {2332-5666}, location = {Bologna, Italy}, pages = {45--52}, publisher = {Institute of Electrical and Electronics Engineers}, title = {{Hierarchical consensus: A horizontal scaling framework for blockchains}}, doi = {10.1109/icdcsw56584.2022.00018}, volume = {2022}, year = {2022}, } @inproceedings{12161, abstract = {We introduce LIMES, a new method for learning with non-stationary streaming data, inspired by the recent success of meta-learning. The main idea is not to attempt to learn a single classifier that would have to work well across all occurring data distributions, nor many separate classifiers, but to exploit a hybrid strategy: we learn a single set of model parameters from which a specific classifier for any specific data distribution is derived via classifier adaptation. Assuming a multiclass classification setting with class-prior shift, the adaptation step can be performed analytically with only the classifier’s bias terms being affected. Another contribution of our work is an extrapolation step that predicts suitable adaptation parameters for future time steps based on the previous data. In combination, we obtain a lightweight procedure for learning from streaming data with varying class distribution that adds no trainable parameters and almost no memory or computational overhead compared to training a single model. Experiments on a set of exemplary tasks using Twitter data show that LIMES achieves higher accuracy than alternative approaches, especially with respect to the relevant real-world metric of lowest within-day accuracy.}, author = {Tomaszewska, Paulina and Lampert, Christoph}, booktitle = {26th International Conference on Pattern Recognition}, issn = {2831-7475}, location = {Montreal, Canada}, pages = {2128--2134}, publisher = {Institute of Electrical and Electronics Engineers}, title = {{Lightweight conditional model extrapolation for streaming data under class-prior shift}}, doi = {10.1109/icpr56361.2022.9956195}, volume = {2022}, year = {2022}, } @inproceedings{12167, abstract = {Payment channels effectively move the transaction load off-chain thereby successfully addressing the inherent scalability problem most cryptocurrencies face. A major drawback of payment channels is the need to “top up” funds on-chain when a channel is depleted. Rebalancing was proposed to alleviate this issue, where parties with depleting channels move their funds along a cycle to replenish their channels off-chain. Protocols for rebalancing so far either introduce local solutions or compromise privacy. In this work, we present an opt-in rebalancing protocol that is both private and globally optimal, meaning our protocol maximizes the total amount of rebalanced funds. We study rebalancing from the framework of linear programming. To obtain full privacy guarantees, we leverage multi-party computation in solving the linear program, which is executed by selected participants to maintain efficiency. Finally, we efficiently decompose the rebalancing solution into incentive-compatible cycles which conserve user balances when executed atomically.}, author = {Avarikioti, Georgia and Pietrzak, Krzysztof Z and Salem, Iosif and Schmid, Stefan and Tiwari, Samarth and Yeo, Michelle X}, booktitle = {Financial Cryptography and Data Security}, isbn = {9783031182822}, issn = {1611-3349}, location = {Grenada}, pages = {358--373}, publisher = {Springer Nature}, title = {{Hide & Seek: Privacy-preserving rebalancing on payment channel networks}}, doi = {10.1007/978-3-031-18283-9_17}, volume = {13411}, year = {2022}, } @inproceedings{12168, abstract = {Advances in blockchains have influenced the State-Machine-Replication (SMR) world and many state-of-the-art blockchain-SMR solutions are based on two pillars: Chaining and Leader-rotation. A predetermined round-robin mechanism used for Leader-rotation, however, has an undesirable behavior: crashed parties become designated leaders infinitely often, slowing down overall system performance. In this paper, we provide a new Leader-Aware SMR framework that, among other desirable properties, formalizes a Leader-utilization requirement that bounds the number of rounds whose leaders are faulty in crash-only executions. We introduce Carousel, a novel, reputation-based Leader-rotation solution to achieve Leader-Aware SMR. The challenge in adaptive Leader-rotation is that it cannot rely on consensus to determine a leader, since consensus itself needs a leader. Carousel uses the available on-chain information to determine a leader locally and achieves Liveness despite this difficulty. A HotStuff implementation fitted with Carousel demonstrates drastic performance improvements: it increases throughput over 2x in faultless settings and provided a 20x throughput increase and 5x latency reduction in the presence of faults.}, author = {Cohen, Shir and Gelashvili, Rati and Kokoris Kogias, Eleftherios and Li, Zekun and Malkhi, Dahlia and Sonnino, Alberto and Spiegelman, Alexander}, booktitle = {International Conference on Financial Cryptography and Data Security}, isbn = {9783031182822}, issn = {1611-3349}, location = {Grenada}, pages = {279--295}, publisher = {Springer Nature}, title = {{Be aware of your leaders}}, doi = {10.1007/978-3-031-18283-9_13}, volume = {13411}, year = {2022}, } @inproceedings{12170, abstract = {We present PET, a specialized and highly optimized framework for partial exploration on probabilistic systems. Over the last decade, several significant advances in the analysis of Markov decision processes employed partial exploration. In a nutshell, this idea allows to focus computation on specific parts of the system, guided by heuristics, while maintaining correctness. In particular, only relevant parts of the system are constructed on demand, which in turn potentially allows to omit constructing large parts of the system. Depending on the model, this leads to dramatic speed-ups, in extreme cases even up to an arbitrary factor. PET unifies several previous implementations and provides a flexible framework to easily implement partial exploration for many further problems. Our experimental evaluation shows significant improvements compared to the previous implementations while vastly reducing the overhead required to add support for additional properties.}, author = {Meggendorfer, Tobias}, booktitle = {20th International Symposium on Automated Technology for Verification and Analysis}, isbn = {9783031199912}, issn = {1611-3349}, location = {Virtual}, pages = {320--326}, publisher = {Springer Nature}, title = {{PET – A partial exploration tool for probabilistic verification}}, doi = {10.1007/978-3-031-19992-9_20}, volume = {13505}, year = {2022}, } @inproceedings{12171, abstract = {We propose an algorithmic approach for synthesizing linear hybrid automata from time-series data. Unlike existing approaches, our approach provides a whole family of models with the same discrete structure but different dynamics. Each model in the family is guaranteed to capture the input data up to a precision error ε, in the following sense: For each time series, the model contains an execution that is ε-close to the data points. Our construction allows to effectively choose a model from this family with minimal precision error ε. We demonstrate the algorithm’s efficiency and its ability to find precise models in two case studies.}, author = {Garcia Soto, Miriam and Henzinger, Thomas A and Schilling, Christian}, booktitle = {20th International Symposium on Automated Technology for Verification and Analysis}, isbn = {9783031199912}, issn = {1611-3349}, location = {Virtual}, pages = {337--353}, publisher = {Springer Nature}, title = {{Synthesis of parametric hybrid automata from time series}}, doi = {10.1007/978-3-031-19992-9_22}, volume = {13505}, year = {2022}, } @article{12173, abstract = {With increasing urbanization and industrialization, the prevalence of inflammatory bowel diseases (IBDs) has steadily been rising over the past two decades. IBD involves flares of gastrointestinal (GI) inflammation accompanied by microbiota perturbations. However, microbial mechanisms that trigger such flares remain elusive. Here, we analyzed the association of the emerging pathogen atypical enteropathogenic E. coli (aEPEC) with IBD disease activity. The presence of diarrheagenic E. coli was assessed in stool samples from 630 IBD patients and 234 age- and sex-matched controls without GI symptoms. Microbiota was analyzed with 16S ribosomal RNA gene amplicon sequencing, and 57 clinical aEPEC isolates were subjected to whole-genome sequencing and in vitro pathogenicity experiments including biofilm formation, epithelial barrier function and the ability to induce pro-inflammatory signaling. The presence of aEPEC correlated with laboratory, clinical and endoscopic disease activity in ulcerative colitis (UC), as well as microbiota dysbiosis. In vitro, aEPEC strains induce epithelial p21-activated kinases, disrupt the epithelial barrier and display potent biofilm formation. The effector proteins espV and espG2 distinguish aEPEC cultured from UC and Crohn’s disease patients, respectively. EspV-positive aEPEC harbor more virulence factors and have a higher pro-inflammatory potential, which is counteracted by 5-ASA. aEPEC may tip a fragile immune–microbiota homeostasis and thereby contribute to flares in UC. aEPEC isolates from UC patients display properties to disrupt the epithelial barrier and to induce pro-inflammatory signaling in vitro.}, author = {Baumgartner, Maximilian and Zirnbauer, Rebecca and Schlager, Sabine and Mertens, Daniel and Gasche, Nikolaus and Sladek, Barbara and Herbold, Craig and Bochkareva, Olga and Emelianenko, Vera and Vogelsang, Harald and Lang, Michaela and Klotz, Anton and Moik, Birgit and Makristathis, Athanasios and Berry, David and Dabsch, Stefanie and Khare, Vineeta and Gasche, Christoph}, issn = {1949-0984}, journal = {Gut Microbes}, keywords = {Infectious Diseases, Microbiology (medical), Gastroenterology, Microbiology}, number = {1}, publisher = {Taylor & Francis}, title = {{Atypical enteropathogenic E. coli are associated with disease activity in ulcerative colitis}}, doi = {10.1080/19490976.2022.2143218}, volume = {14}, year = {2022}, } @article{12174, abstract = {Vacuolar-type H+-ATPase (V-ATPase) is a multimeric complex present in a variety of cellular membranes that acts as an ATP-dependent proton pump and plays a key role in pH homeostasis and intracellular signalling pathways. In humans, 22 autosomal genes encode for a redundant set of subunits allowing the composition of diverse V-ATPase complexes with specific properties and expression. Sixteen subunits have been linked to human disease. Here we describe 26 patients harbouring 20 distinct pathogenic de novo missense ATP6V1A variants, mainly clustering within the ATP synthase α/β family-nucleotide-binding domain. At a mean age of 7 years (extremes: 6 weeks, youngest deceased patient to 22 years, oldest patient) clinical pictures included early lethal encephalopathies with rapidly progressive massive brain atrophy, severe developmental epileptic encephalopathies and static intellectual disability with epilepsy. The first clinical manifestation was early hypotonia, in 70%; 81% developed epilepsy, manifested as developmental epileptic encephalopathies in 58% of the cohort and with infantile spasms in 62%; 63% of developmental epileptic encephalopathies failed to achieve any developmental, communicative or motor skills. Less severe outcomes were observed in 23% of patients who, at a mean age of 10 years and 6 months, exhibited moderate intellectual disability, with independent walking and variable epilepsy. None of the patients developed communicative language. Microcephaly (38%) and amelogenesis imperfecta/enamel dysplasia (42%) were additional clinical features. Brain MRI demonstrated hypomyelination and generalized atrophy in 68%. Atrophy was progressive in all eight individuals undergoing repeated MRIs. Fibroblasts of two patients with developmental epileptic encephalopathies showed decreased LAMP1 expression, Lysotracker staining and increased organelle pH, consistent with lysosomal impairment and loss of V-ATPase function. Fibroblasts of two patients with milder disease, exhibited a different phenotype with increased Lysotracker staining, decreased organelle pH and no significant modification in LAMP1 expression. Quantification of substrates for lysosomal enzymes in cellular extracts from four patients revealed discrete accumulation. Transmission electron microscopy of fibroblasts of four patients with variable severity and of induced pluripotent stem cell-derived neurons from two patients with developmental epileptic encephalopathies showed electron-dense inclusions, lipid droplets, osmiophilic material and lamellated membrane structures resembling phospholipids. Quantitative assessment in induced pluripotent stem cell-derived neurons identified significantly smaller lysosomes. ATP6V1A-related encephalopathy represents a new paradigm among lysosomal disorders. It results from a dysfunctional endo-lysosomal membrane protein causing altered pH homeostasis. Its pathophysiology implies intracellular accumulation of substrates whose composition remains unclear, and a combination of developmental brain abnormalities and neurodegenerative changes established during prenatal and early postanal development, whose severity is variably determined by specific pathogenic variants.}, author = {Guerrini, Renzo and Mei, Davide and Szigeti, Margit Katalin and Pepe, Sara and Koenig, Mary Kay and Von Allmen, Gretchen and Cho, Megan T and McDonald, Kimberly and Baker, Janice and Bhambhani, Vikas and Powis, Zöe and Rodan, Lance and Nabbout, Rima and Barcia, Giulia and Rosenfeld, Jill A and Bacino, Carlos A and Mignot, Cyril and Power, Lillian H and Harris, Catharine J and Marjanovic, Dragan and Møller, Rikke S and Hammer, Trine B and Keski Filppula, Riikka and Vieira, Päivi and Hildebrandt, Clara and Sacharow, Stephanie and Maragliano, Luca and Benfenati, Fabio and Lachlan, Katherine and Benneche, Andreas and Petit, Florence and de Sainte Agathe, Jean Madeleine and Hallinan, Barbara and Si, Yue and Wentzensen, Ingrid M and Zou, Fanggeng and Narayanan, Vinodh and Matsumoto, Naomichi and Boncristiano, Alessandra and la Marca, Giancarlo and Kato, Mitsuhiro and Anderson, Kristin and Barba, Carmen and Sturiale, Luisa and Garozzo, Domenico and Bei, Roberto and Masuelli, Laura and Conti, Valerio and Novarino, Gaia and Fassio, Anna}, issn = {1460-2156}, journal = {Brain}, keywords = {Neurology (clinical)}, number = {8}, pages = {2687--2703}, publisher = {Oxford University Press}, title = {{Phenotypic and genetic spectrum of ATP6V1A encephalopathy: A disorder of lysosomal homeostasis}}, doi = {10.1093/brain/awac145}, volume = {145}, year = {2022}, } @inproceedings{12175, abstract = {An automaton is history-deterministic (HD) if one can safely resolve its non-deterministic choices on the fly. In a recent paper, Henzinger, Lehtinen and Totzke studied this in the context of Timed Automata [9], where it was conjectured that the class of timed ω-languages recognised by HD-timed automata strictly extends that of deterministic ones. We provide a proof for this fact.}, author = {Bose, Sougata and Henzinger, Thomas A and Lehtinen, Karoliina and Schewe, Sven and Totzke, Patrick}, booktitle = {16th International Conference on Reachability Problems}, isbn = {9783031191343}, issn = {1611-3349}, location = {Kaiserslautern, Germany}, pages = {67--76}, publisher = {Springer Nature}, title = {{History-deterministic timed automata are not determinizable}}, doi = {10.1007/978-3-031-19135-0_5}, volume = {13608}, year = {2022}, } @article{12177, abstract = {Using elementary hyperbolic geometry, we give an explicit formula for the contraction constant of the skinning map over moduli spaces of relatively acylindrical hyperbolic manifolds.}, author = {Cremaschi, Tommaso and Dello Schiavo, Lorenzo}, issn = {2330-1511}, journal = {Proceedings of the American Mathematical Society, Series B}, number = {43}, pages = {445--459}, publisher = {American Mathematical Society}, title = {{Effective contraction of Skinning maps}}, doi = {10.1090/bproc/134}, volume = {9}, year = {2022}, } @article{12179, abstract = {We derive an accurate lower tail estimate on the lowest singular value σ1(X−z) of a real Gaussian (Ginibre) random matrix X shifted by a complex parameter z. Such shift effectively changes the upper tail behavior of the condition number κ(X−z) from the slower (κ(X−z)≥t)≲1/t decay typical for real Ginibre matrices to the faster 1/t2 decay seen for complex Ginibre matrices as long as z is away from the real axis. This sharpens and resolves a recent conjecture in [J. Banks et al., https://arxiv.org/abs/2005.08930, 2020] on the regularizing effect of the real Ginibre ensemble with a genuinely complex shift. As a consequence we obtain an improved upper bound on the eigenvalue condition numbers (known also as the eigenvector overlaps) for real Ginibre matrices. The main technical tool is a rigorous supersymmetric analysis from our earlier work [Probab. Math. Phys., 1 (2020), pp. 101--146].}, author = {Cipolloni, Giorgio and Erdös, László and Schröder, Dominik J}, issn = {1095-7162}, journal = {SIAM Journal on Matrix Analysis and Applications}, keywords = {Analysis}, number = {3}, pages = {1469--1487}, publisher = {Society for Industrial and Applied Mathematics}, title = {{On the condition number of the shifted real Ginibre ensemble}}, doi = {10.1137/21m1424408}, volume = {43}, year = {2022}, }