@article{12583, abstract = {Peruvian glaciers are important contributors to dry season runoff for agriculture and hydropower, but they are at risk of disappearing due to climate change. We applied a physically based, energy balance melt model at five on-glacier sites within the Peruvian Cordilleras Blanca and Vilcanota. Net shortwave radiation dominates the energy balance, and despite this flux being higher in the dry season, melt rates are lower due to losses from net longwave radiation and the latent heat flux. The sensible heat flux is a relatively small contributor to melt energy. At three of the sites the wet season snowpack was discontinuous, forming and melting within a daily to weekly timescale, and resulting in highly variable melt rates closely related to precipitation dynamics. Cold air temperatures due to a strong La Niña year at Shallap Glacier (Cordillera Blanca) resulted in a continuous wet season snowpack, significantly reducing wet season ablation. Sublimation was most important at the highest site in the accumulation zone of the Quelccaya Ice Cap (Cordillera Vilcanota), accounting for 81% of ablation, compared to 2%–4% for the other sites. Air temperature and precipitation inputs were perturbed to investigate the climate sensitivity of the five glaciers. At the lower sites warmer air temperatures resulted in a switch from snowfall to rain, so that ablation was increased via the decrease in albedo and increase in net shortwave radiation. At the top of Quelccaya Ice Cap warming caused melting to replace sublimation so that ablation increased nonlinearly with air temperature.}, author = {Fyffe, Catriona L. and Potter, Emily and Fugger, Stefan and Orr, Andrew and Fatichi, Simone and Loarte, Edwin and Medina, Katy and Hellström, Robert Å. and Bernat, Maud and Aubry‐Wake, Caroline and Gurgiser, Wolfgang and Perry, L. Baker and Suarez, Wilson and Quincey, Duncan J. and Pellicciotti, Francesca}, issn = {2169-8996}, journal = {Journal of Geophysical Research: Atmospheres}, keywords = {Space and Planetary Science, Earth and Planetary Sciences (miscellaneous), Atmospheric Science, Geophysics}, number = {23}, publisher = {American Geophysical Union}, title = {{The energy and mass balance of Peruvian Glaciers}}, doi = {10.1029/2021jd034911}, volume = {126}, year = {2021}, } @article{12584, abstract = {This project explored the integrated use of satellite, ground observations and hydrological distributed models to support water resources assessment and monitoring in High Mountain Asia (HMA). Hydrological data products were generated taking advantage of the synergies of European and Chinese data assets and space-borne observation systems. Energy-budget-based glacier mass balance and hydrological models driven by satellite observations were developed. These models can be applied to describe glacier-melt contribution to river flow. Satellite hydrological data products were used for forcing, calibration, validation and data assimilation in distributed river basin models. A pilot study was carried out on the Red River basin. Multiple hydrological data products were generated using the data collected by Chinese satellites. A new Evapo-Transpiration (ET) dataset from 2000 to 2018 was generated, including plant transpiration, soil evaporation, rainfall interception loss, snow/ice sublimation and open water evaporation. Higher resolution data were used to characterize glaciers and their response to environmental forcing. These studies focused on the Parlung Zangbo Basin, where glacier facies were mapped with GaoFeng (GF), Sentinal-2/Multi-Spectral Imager (S2/MSI) and Landsat8/Operational Land Imager (L8/OLI) data. The geodetic mass balance was estimated between 2000 and 2017 with Zi-Yuan (ZY)-3 Stereo Images and the SRTM DEM. Surface velocity was studied with Landsat5/Thematic Mapper (L5/TM), L8/OLI and S2/MSI data over the period 2013–2019. An updated method was developed to improve the retrieval of glacier albedo by correcting glacier reflectance for anisotropy, and a new dataset on glacier albedo was generated for the period 2001–2020. A detailed glacier energy and mass balance model was developed with the support of field experiments at the Parlung No. 4 Glacier and the 24 K Glacier, both in the Tibetan Plateau. Besides meteorological measurements, the field experiments included glaciological and hydrological measurements. The energy balance model was formulated in terms of enthalpy for easier treatment of water phase transitions. The model was applied to assess the spatial variability in glacier melt. In the Parlung No. 4 Glacier, the accumulated glacier melt was between 1.5 and 2.5 m w.e. in the accumulation zone and between 4.5 and 6.0 m w.e. in the ablation zone, reaching 6.5 m w.e. at the terminus. The seasonality in the glacier mass balance was observed by combining intensive field campaigns with continuous automatic observations. The linkage of the glacier and snowpack mass balance with water resources in a river basin was analyzed in the Chiese (Italy) and Heihe (China) basins by developing and applying integrated hydrological models using satellite retrievals in multiple ways. The model FEST-WEB was calibrated using retrievals of Land Surface Temperature (LST) to map soil hydrological properties. A watershed model was developed by coupling ecohydrological and socioeconomic systems. Integrated modeling is supported by an updated and parallelized data assimilation system. The latter exploits retrievals of brightness temperature (Advanced Microwave Scanning Radiometer, AMSR), LST (Moderate Resolution Imaging Spectroradiometer, MODIS), precipitation (Tropical Rainfall Measuring Mission (TRMM) and FengYun (FY)-2D) and in-situ measurements. In the case study on the Red River Basin, a new algorithm has been applied to disaggregate the SMOS (Soil Moisture and Ocean Salinity) soil moisture retrievals by making use of the correlation between evaporative fraction and soil moisture.}, author = {Menenti, Massimo and Li, Xin and Jia, Li and Yang, Kun and Pellicciotti, Francesca and Mancini, Marco and Shi, Jiancheng and Escorihuela, Maria José and Zheng, Chaolei and Chen, Qiting and Lu, Jing and Zhou, Jie and Hu, Guangcheng and Ren, Shaoting and Zhang, Jing and Liu, Qinhuo and Qiu, Yubao and Huang, Chunlin and Zhou, Ji and Han, Xujun and Pan, Xiaoduo and Li, Hongyi and Wu, Yerong and Ding, Baohong and Yang, Wei and Buri, Pascal and McCarthy, Michael J. and Miles, Evan S. and Shaw, Thomas E. and Ma, Chunfeng and Zhou, Yanzhao and Corbari, Chiara and Li, Rui and Zhao, Tianjie and Stefan, Vivien and Gao, Qi and Zhang, Jingxiao and Xie, Qiuxia and Wang, Ning and Sun, Yibo and Mo, Xinyu and Jia, Junru and Jouberton, Achille Pierre and Kneib, Marin and Fugger, Stefan and Paciolla, Nicola and Paolini, Giovanni}, issn = {2072-4292}, journal = {Remote Sensing}, keywords = {General Earth and Planetary Sciences}, number = {24}, publisher = {MDPI}, title = {{Multi-source hydrological data products to monitor High Asian river basins and regional water security}}, doi = {10.3390/rs13245122}, volume = {13}, year = {2021}, } @article{12585, abstract = {Glaciers in High Mountain Asia generate meltwater that supports the water needs of 250 million people, but current knowledge of annual accumulation and ablation is limited to sparse field measurements biased in location and glacier size. Here, we present altitudinally-resolved specific mass balances (surface, internal, and basal combined) for 5527 glaciers in High Mountain Asia for 2000–2016, derived by correcting observed glacier thinning patterns for mass redistribution due to ice flow. We find that 41% of glaciers accumulated mass over less than 20% of their area, and only 60% ± 10% of regional annual ablation was compensated by accumulation. Even without 21st century warming, 21% ± 1% of ice volume will be lost by 2100 due to current climatic-geometric imbalance, representing a reduction in glacier ablation into rivers of 28% ± 1%. The ablation of glaciers in the Himalayas and Tien Shan was mostly unsustainable and ice volume in these regions will reduce by at least 30% by 2100. The most important and vulnerable glacier-fed river basins (Amu Darya, Indus, Syr Darya, Tarim Interior) were supplied with >50% sustainable glacier ablation but will see long-term reductions in ice mass and glacier meltwater supply regardless of the Karakoram Anomaly.}, author = {Miles, Evan and McCarthy, Michael and Dehecq, Amaury and Kneib, Marin and Fugger, Stefan and Pellicciotti, Francesca}, issn = {2041-1723}, journal = {Nature Communications}, keywords = {General Physics and Astronomy, General Biochemistry, Genetics and Molecular Biology, General Chemistry, Multidisciplinary}, publisher = {Springer Nature}, title = {{Health and sustainability of glaciers in High Mountain Asia}}, doi = {10.1038/s41467-021-23073-4}, volume = {12}, year = {2021}, } @article{12586, abstract = {Ice cliffs are common on debris-covered glaciers and have relatively high melt rates due to their direct exposure to incoming radiation. Previous studies have shown that their number and relative area can change considerably from year to year, but this variability has not been explored, in part because available cliff observations are irregular. Here, we systematically mapped and tracked ice cliffs across four debris-covered glaciers in High Mountain Asia for every late ablation season from 2009 to 2019 using high-resolution multi-spectral satellite imagery. We then quantified the processes occurring at the feature scale to train a stochastic birth-death model to represent the cliff population dynamics. Our results show that while the cliff relative area can change by up to 20% from year to year, the natural long-term variability is constrained, thus defining a glacier-specific cliff carrying capacity. In a subsequent step, the inclusion of external drivers related to climate, glacier dynamics, and hydrology highlights the influence of these variables on the cliff population dynamics, which is usually not a direct one due to the complexity and interdependence of the processes taking place at the glacier surface. In some extreme cases (here, a glacier surge), these external drivers may lead to a reorganization of the cliffs at the glacier surface and a change in the natural variability. These results have implications for the melt of debris-covered glaciers, in addition to showing the high rate of changes at their surface and highlighting some of the links between cliff population and glacier state.}, author = {Kneib, M. and Miles, E. S. and Buri, P. and Molnar, P. and McCarthy, M. and Fugger, S. and Pellicciotti, Francesca}, issn = {2169-9003}, journal = {Journal of Geophysical Research: Earth Surface}, keywords = {Earth-Surface Processes, Geophysics}, number = {10}, publisher = {American Geophysical Union}, title = {{Interannual dynamics of ice cliff populations on debris‐covered glaciers from remote sensing observations and stochastic modeling}}, doi = {10.1029/2021jf006179}, volume = {126}, year = {2021}, } @article{12587, abstract = {Surface energy-balance models are commonly used in conjunction with satellite thermal imagery to estimate supraglacial debris thickness. Removing the need for local meteorological data in the debris thickness estimation workflow could improve the versatility and spatiotemporal application of debris thickness estimation. We evaluate the use of regional reanalysis data to derive debris thickness for two mountain glaciers using a surface energy-balance model. Results forced using ERA-5 agree with AWS-derived estimates to within 0.01 ± 0.05 m for Miage Glacier, Italy, and 0.01 ± 0.02 m for Khumbu Glacier, Nepal. ERA-5 data were then used to estimate spatiotemporal changes in debris thickness over a ~20-year period for Miage Glacier, Khumbu Glacier and Haut Glacier d'Arolla, Switzerland. We observe significant increases in debris thickness at the terminus for Haut Glacier d'Arolla and at the margins of the expanding debris cover at all glaciers. While simulated debris thickness was underestimated compared to point measurements in areas of thick debris, our approach can reconstruct glacier-scale debris thickness distribution and its temporal evolution over multiple decades. We find significant changes in debris thickness over areas of thin debris, areas susceptible to high ablation rates, where current knowledge of debris evolution is limited.}, author = {Stewart, Rebecca L. and Westoby, Matthew and Pellicciotti, Francesca and Rowan, Ann and Swift, Darrel and Brock, Benjamin and Woodward, John}, issn = {1727-5652}, journal = {Journal of Glaciology}, number = {262}, pages = {366--384}, publisher = {Cambridge University Press}, title = {{Using climate reanalysis data in conjunction with multi-temporal satellite thermal imagery to derive supraglacial debris thickness changes from energy-balance modelling}}, doi = {10.1017/jog.2020.111}, volume = {67}, year = {2021}, } @article{12588, abstract = {The thinning patterns of debris-covered glaciers in High Mountain Asia are not well understood. Here we calculate the effect of supraglacial ice cliffs on the mass balance of all glaciers in a Himalayan catchment, using a process-based ice cliff melt model. We show that ice cliffs are responsible for higher than expected thinning rates of debris-covered glacier tongues, leading to an underestimation of their ice mass loss of 17% ± 4% in the catchment if not considered. We also show that cliffs do enhance melt where other processes would suppress it, that is, at high elevations, or where debris is thick, and that they contribute relatively more to glacier mass loss if oriented north. Our approach provides a key contribution to our understanding of the mass losses of debris-covered glaciers, and a new quantification of their catchment wide melt and mass balance.}, author = {Buri, Pascal and Miles, Evan S. and Steiner, Jakob F. and Ragettli, Silvan and Pellicciotti, Francesca}, issn = {1944-8007}, journal = {Geophysical Research Letters}, keywords = {General Earth and Planetary Sciences, Geophysics}, number = {6}, publisher = {American Geophysical Union}, title = {{Supraglacial ice cliffs can substantially increase the mass loss of debris‐covered glaciers}}, doi = {10.1029/2020gl092150}, volume = {48}, year = {2021}, } @article{12589, abstract = {Near-surface air temperature (Ta) is highly important for modelling glacier ablation, though its spatio-temporal variability over melting glaciers still remains largely unknown. We present a new dataset of distributed Ta for three glaciers of different size in the south-east Tibetan Plateau during two monsoon-dominated summer seasons. We compare on-glacier Ta to ambient Ta extrapolated from several local off-glacier stations. We parameterise the along-flowline sensitivity of Ta on these glaciers to changes in off-glacier temperatures (referred to as “temperature sensitivity”) and present the results in the context of available distributed on-glacier datasets around the world. Temperature sensitivity decreases rapidly up to 2000–3000 m along the down-glacier flowline distance. Beyond this distance, both the Ta on the Tibetan glaciers and global glacier datasets show little additional cooling relative to the off-glacier temperature. In general, Ta on small glaciers (with flowline distances <1000 m) is highly sensitive to temperature changes outside the glacier boundary layer. The climatology of a given region can influence the general magnitude of this temperature sensitivity, though no strong relationships are found between along-flowline temperature sensitivity and mean summer temperatures or precipitation. The terminus of some glaciers is affected by other warm-air processes that increase temperature sensitivity (such as divergent boundary layer flow, warm up-valley winds or debris/valley heating effects) which are evident only beyond ∼70 % of the total glacier flowline distance. Our results therefore suggest a strong role of local effects in modulating temperature sensitivity close to the glacier terminus, although further work is still required to explain the variability of these effects for different glaciers.}, author = {Shaw, Thomas E. and Yang, Wei and Ayala, Álvaro and Bravo, Claudio and Zhao, Chuanxi and Pellicciotti, Francesca}, issn = {1994-0424}, journal = {The Cryosphere}, keywords = {Earth-Surface Processes, Water Science and Technology}, number = {2}, pages = {595--614}, publisher = {Copernicus Publications}, title = {{Distributed summer air temperatures across mountain glaciers in the south-east Tibetan Plateau: Temperature sensitivity and comparison with existing glacier datasets}}, doi = {10.5194/tc-15-595-2021}, volume = {15}, year = {2021}, } @article{12590, abstract = {Ice cliffs play a key role in the mass balance of debris-covered glaciers, but assessing their importance is limited by a lack of datasets on their distribution and evolution at scales larger than an individual glacier. These datasets are often derived using operator-biased and time-consuming manual delineation approaches, despite the recent emergence of semi-automatic mapping methods. These methods have used elevation or multispectral data, but the varying slope and mixed spectral signal of these dynamic features makes the transferability of these approaches particularly challenging. We develop three semi-automated and objective new approaches, based on the Spectral Curvature and Linear Spectral Unmixing of multispectral images, to map these features at a glacier to regional scale. The transferability of each method is assessed by applying it to three sites in the Himalaya, where debris-covered glaciers are widespread, with varying lithologic, glaciological and climatic settings, and encompassing different periods of the melt season. We develop the new methods keeping in mind the wide range of remote sensing platforms currently in use, and focus in particular on two products: we apply the three approaches at each site to near-contemporaneous atmospherically-corrected Pléiades (2 m resolution) and Sentinel-2 (10 m resolution) images and assess the effects of spatial and spectral resolution on the results. We find that the Spectral Curvature method works best for the high spatial resolution, four band Pléaides images, while a modification of the Linear Spectral Unmixing using the scaling factor of the unmixing is best for the coarser spatial resolution, but additional spectral information of Sentinel-2 products. In both cases ice cliffs are mapped with a Dice coefficient higher than 0.48. Comparison of the Pléiades results with other existing methods shows that the Spectral Curvature approach performs better and is more robust than any other existing automated or semi-automated approaches. Both methods outline a high number of small, sometimes shallow-sloping and thinly debris-covered ice patches that differ from our traditional understanding of cliffs but may have non-negligible impact on the mass balance of debris-covered glaciers. Overall these results pave the way for large scale efforts of ice cliff mapping that can enable inclusion of these features in debris-covered glacier melt models, as well as allow the generation of multiple datasets to study processes of cliff formation, evolution and decline.}, author = {Kneib, M. and Miles, E.S. and Jola, S. and Buri, P. and Herreid, S. and Bhattacharya, A. and Watson, C.S. and Bolch, T. and Quincey, D. and Pellicciotti, Francesca}, issn = {0034-4257}, journal = {Remote Sensing of Environment}, keywords = {Computers in Earth Sciences, Geology, Soil Science}, number = {2}, publisher = {Elsevier}, title = {{Mapping ice cliffs on debris-covered glaciers using multispectral satellite images}}, doi = {10.1016/j.rse.2020.112201}, volume = {253}, year = {2021}, } @article{12591, abstract = {Glacier albedo determines the net shortwave radiation absorbed at the glacier surface and plays a crucial role in glacier energy and mass balance. Remote sensing techniques are efficient means to retrieve glacier surface albedo over large and inaccessible areas and to study its variability. However, corrections of anisotropic reflectance of glacier surface have been established for specific shortwave bands only, such as Landsat 5 Thematic Mapper (L5/TM) band 2 and band 4, which is a major limitation of current retrievals of glacier broadband albedo. In this study, we calibrated and evaluated four anisotropy correction models for glacier snow and ice, applicable to visible, near-infrared and shortwave-infrared wavelengths using airborne datasets of Bidirectional Reflectance Distribution Function (BRDF). We then tested the ability of the best-performing anisotropy correction model, referred to from here on as the ‘updated model’, to retrieve albedo from L5/TM, Landsat 8 Operational Land Imager (L8/OLI) and Moderate Resolution Imaging Spectroradiometer (MODIS) imagery, and evaluated these results with field measurements collected on eight glaciers around the world. Our results show that the updated model: (1) can accurately estimate anisotropic factors of reflectance for snow and ice surfaces; (2) generally performs better than prior approaches for L8/OLI albedo retrieval but is not appropriate for L5/TM; (3) generally retrieves MODIS albedo better than the MODIS standard albedo product (MCD43A3) in both absolute values and glacier albedo temporal evolution, i.e., exhibiting both fewer gaps and better agreement with field observations. As the updated model enables anisotropy correction of a maximum of 10 multispectral bands and is implemented in Google Earth Engine (GEE), it is promising for observing and analyzing glacier albedo at large spatial scales.}, author = {Ren, Shaoting and Miles, Evan S. and Jia, Li and Menenti, Massimo and Kneib, Marin and Buri, Pascal and McCarthy, Michael J. and Shaw, Thomas E. and Yang, Wei and Pellicciotti, Francesca}, issn = {2072-4292}, journal = {Remote Sensing}, number = {9}, publisher = {MDPI}, title = {{Anisotropy parameterization development and evaluation for glacier surface albedo retrieval from satellite observations}}, doi = {10.3390/rs13091714}, volume = {13}, year = {2021}, } @article{12667, abstract = {Unlike crystalline atomic and ionic solids, texture development due to crystallographically preferred growth in colloidal crystals is less studied. Here we investigate the underlying mechanisms of the texture evolution in an evaporation-induced colloidal assembly process through experiments, modeling, and theoretical analysis. In this widely used approach to obtain large-area colloidal crystals, the colloidal particles are driven to the meniscus via the evaporation of a solvent or matrix precursor solution where they close-pack to form a face-centered cubic colloidal assembly. Via two-dimensional large-area crystallographic mapping, we show that the initial crystal orientation is dominated by the interaction of particles with the meniscus, resulting in the expected coalignment of the close-packed direction with the local meniscus geometry. By combining with crystal structure analysis at a single-particle level, we further reveal that, at the later stage of self-assembly, however, the colloidal crystal undergoes a gradual rotation facilitated by geometrically necessary dislocations (GNDs) and achieves a large-area uniform crystallographic orientation with the close-packed direction perpendicular to the meniscus and parallel to the growth direction. Classical slip analysis, finite element-based mechanical simulation, computational colloidal assembly modeling, and continuum theory unequivocally show that these GNDs result from the tensile stress field along the meniscus direction due to the constrained shrinkage of the colloidal crystal during drying. The generation of GNDs with specific slip systems within individual grains leads to crystallographic rotation to accommodate the mechanical stress. The mechanistic understanding reported here can be utilized to control crystallographic features of colloidal assemblies, and may provide further insights into crystallographically preferred growth in synthetic, biological, and geological crystals.}, author = {Li, Ling and Goodrich, Carl Peter and Yang, Haizhao and Phillips, Katherine R. and Jia, Zian and Chen, Hongshun and Wang, Lifeng and Zhong, Jinjin and Liu, Anhua and Lu, Jianfeng and Shuai, Jianwei and Brenner, Michael P. and Spaepen, Frans and Aizenberg, Joanna}, issn = {1091-6490}, journal = {PNAS}, number = {32}, publisher = {Proceedings of the National Academy of Sciences}, title = {{Microscopic origins of the crystallographically preferred growth in evaporation-induced colloidal crystals}}, doi = {10.1073/pnas.2107588118}, volume = {118}, year = {2021}, } @inproceedings{12767, abstract = {Several problems in planning and reactive synthesis can be reduced to the analysis of two-player quantitative graph games. Optimization is one form of analysis. We argue that in many cases it may be better to replace the optimization problem with the satisficing problem, where instead of searching for optimal solutions, the goal is to search for solutions that adhere to a given threshold bound. This work defines and investigates the satisficing problem on a two-player graph game with the discounted-sum cost model. We show that while the satisficing problem can be solved using numerical methods just like the optimization problem, this approach does not render compelling benefits over optimization. When the discount factor is, however, an integer, we present another approach to satisficing, which is purely based on automata methods. We show that this approach is algorithmically more performant – both theoretically and empirically – and demonstrates the broader applicability of satisficing over optimization.}, author = {Bansal, Suguman and Chatterjee, Krishnendu and Vardi, Moshe Y.}, booktitle = {27th International Conference on Tools and Algorithms for the Construction and Analysis of Systems}, isbn = {9783030720155}, issn = {1611-3349}, location = {Luxembourg City, Luxembourg}, pages = {20--37}, publisher = {Springer Nature}, title = {{On satisficing in quantitative games}}, doi = {10.1007/978-3-030-72016-2_2}, volume = {12651}, year = {2021}, } @misc{13058, abstract = {The zip file includes source data used in the main text of the manuscript "Theory of branching morphogenesis by local interactions and global guidance", as well as a representative Jupyter notebook to reproduce the main figures. A sample script for the simulations of branching and annihilating random walks is also included (Sample_script_for_simulations_of_BARWs.ipynb) to generate exemplary branched networks under external guidance. A detailed description of the simulation setup is provided in the supplementary information of the manuscipt.}, author = {Ucar, Mehmet C}, publisher = {Zenodo}, title = {{Source data for the manuscript "Theory of branching morphogenesis by local interactions and global guidance"}}, doi = {10.5281/ZENODO.5257160}, year = {2021}, } @misc{13061, abstract = {Infections early in life can have enduring effects on an organism’s development and immunity. In this study, we show that this equally applies to developing “superorganisms” – incipient social insect colonies. When we exposed newly mated Lasius niger ant queens to a low pathogen dose, their colonies grew more slowly than controls before winter, but reached similar sizes afterwards. Independent of exposure, queen hibernation survival improved when the ratio of pupae to workers was small. Queens that reared fewer pupae before worker emergence exhibited lower pathogen levels, indicating that high brood rearing efforts interfere with the ability of the queen’s immune system to suppress pathogen proliferation. Early-life queen pathogen-exposure also improved the immunocompetence of her worker offspring, as demonstrated by challenging the workers to the same pathogen a year later. Transgenerational transfer of the queen’s pathogen experience to her workforce can hence durably reduce the disease susceptibility of the whole superorganism.}, author = {Casillas Perez, Barbara E and Pull, Christopher and Naiser, Filip and Naderlinger, Elisabeth and Matas, Jiri and Cremer, Sylvia}, publisher = {Dryad}, title = {{Early queen infection shapes developmental dynamics and induces long-term disease protection in incipient ant colonies}}, doi = {10.5061/DRYAD.7PVMCVDTJ}, year = {2021}, } @misc{13062, abstract = {This paper analyzes the conditions for local adaptation in a metapopulation with infinitely many islands under a model of hard selection, where population size depends on local fitness. Each island belongs to one of two distinct ecological niches or habitats. Fitness is influenced by an additive trait which is under habitat-dependent directional selection. Our analysis is based on the diffusion approximation and accounts for both genetic drift and demographic stochasticity. By neglecting linkage disequilibria, it yields the joint distribution of allele frequencies and population size on each island. We find that under hard selection, the conditions for local adaptation in a rare habitat are more restrictive for more polygenic traits: even moderate migration load per locus at very many loci is sufficient for population sizes to decline. This further reduces the efficacy of selection at individual loci due to increased drift and because smaller populations are more prone to swamping due to migration, causing a positive feedback between increasing maladaptation and declining population sizes. Our analysis also highlights the importance of demographic stochasticity, which exacerbates the decline in numbers of maladapted populations, leading to population collapse in the rare habitat at significantly lower migration than predicted by deterministic arguments.}, author = {Szep, Eniko and Sachdeva, Himani and Barton, Nicholas H}, publisher = {Dryad}, title = {{Supplementary code for: Polygenic local adaptation in metapopulations: A stochastic eco-evolutionary model}}, doi = {10.5061/DRYAD.8GTHT76P1}, year = {2021}, } @misc{13063, abstract = {We develop a Bayesian model (BayesRR-RC) that provides robust SNP-heritability estimation, an alternative to marker discovery, and accurate genomic prediction, taking 22 seconds per iteration to estimate 8.4 million SNP-effects and 78 SNP-heritability parameters in the UK Biobank. We find that only $\leq$ 10\% of the genetic variation captured for height, body mass index, cardiovascular disease, and type 2 diabetes is attributable to proximal regulatory regions within 10kb upstream of genes, while 12-25% is attributed to coding regions, 32-44% to introns, and 22-28% to distal 10-500kb upstream regions. Up to 24% of all cis and coding regions of each chromosome are associated with each trait, with over 3,100 independent exonic and intronic regions and over 5,400 independent regulatory regions having >95% probability of contributing >0.001% to the genetic variance of these four traits. Our open-source software (GMRM) provides a scalable alternative to current approaches for biobank data.}, author = {Robinson, Matthew Richard}, publisher = {Dryad}, title = {{Probabilistic inference of the genetic architecture of functional enrichment of complex traits}}, doi = {10.5061/dryad.sqv9s4n51}, year = {2021}, } @misc{13068, abstract = {Source data and source code for the graphs in "Spatiotemporal dynamics of self-organized branching pancreatic cancer-derived organoids".}, author = {Randriamanantsoa, Samuel and Papargyriou, Aristeidis and Maurer, Carlo and Peschke, Katja and Schuster, Maximilian and Zecchin, Giulia and Steiger, Katja and Öllinger, Rupert and Saur, Dieter and Scheel, Christina and Rad, Roland and Hannezo, Edouard B and Reichert, Maximilian and Bausch, Andreas R.}, publisher = {Zenodo}, title = {{Spatiotemporal dynamics of self-organized branching in pancreas-derived organoids}}, doi = {10.5281/ZENODO.5148117}, year = {2021}, } @misc{13069, abstract = {To survive elevated temperatures, ectotherms adjust the fluidity of membranes by fine-tuning lipid desaturation levels in a process previously described to be cell-autonomous. We have discovered that, in Caenorhabditis elegans, neuronal Heat shock Factor 1 (HSF-1), the conserved master regulator of the heat shock response (HSR)- causes extensive fat remodelling in peripheral tissues. These changes include a decrease in fat desaturase and acid lipase expression in the intestine, and a global shift in the saturation levels of plasma membrane’s phospholipids. The observed remodelling of plasma membrane is in line with ectothermic adaptive responses and gives worms a cumulative advantage to warm temperatures. We have determined that at least six TAX-2/TAX-4 cGMP gated channel expressing sensory neurons and TGF-β/BMP are required for signalling across tissues to modulate fat desaturation. We also find neuronal hsf-1 is not only sufficient but also partially necessary to control the fat remodelling response and for survival at warm temperatures. This is the first study to show that a thermostat-based mechanism can cell non-autonomously coordinate membrane saturation and composition across tissues in a multicellular animal.}, author = {Chauve, Laetitia and Hodge, Francesca and Murdoch, Sharlene and Masoudzadeh, Fatemah and Mann, Harry-Jack and Lopez-Clavijo, Andrea and Okkenhaug, Hanneke and West, Greg and Sousa, Bebiana C. and Segonds-Pichon, Anne and Li, Cheryl and Wingett, Steven and Kienberger, Hermine and Kleigrewe, Karin and de Bono, Mario and Wakelam, Michael and Casanueva, Olivia}, publisher = {Zenodo}, title = {{Neuronal HSF-1 coordinates the propagation of fat desaturation across tissues to enable adaptation to high temperatures in C. elegans}}, doi = {10.5281/ZENODO.5519410}, year = {2021}, } @misc{13072, abstract = {CpGs and corresponding mean weights for DNAm-based prediction of cognitive abilities (6 traits)}, author = {McCartney, Daniel L and Hillary, Robert F and Conole, Eleanor LS and Trejo Banos, Daniel and Gadd, Danni A and Walker, Rosie M and Nangle, Cliff and Flaig, Robin and Campbell, Archie and Murray, Alison D and Munoz Maniega, Susana and del C Valdes-Hernandez, Maria and Harris, Mathew A and Bastin, Mark E and Wardlaw, Joanna M and Harris, Sarah E and Porteous, David J and Tucker-Drob, Elliot M and McIntosh, Andrew M and Evans, Kathryn L and Deary, Ian J and Cox, Simon R and Robinson, Matthew Richard and Marioni, Riccardo E}, publisher = {Zenodo}, title = {{Blood-based epigenome-wide analyses of cognitive abilities}}, doi = {10.5281/ZENODO.5794028}, year = {2021}, } @misc{13080, abstract = {Data for the manuscript 'Closing of the Induced Gap in a Hybrid Superconductor-Semiconductor Nanowire' ([2006.01275] Closing of the Induced Gap in a Hybrid Superconductor-Semiconductor Nanowire (arxiv.org)) We upload a pdf with extended data sets, and the raw data for these extended datasets as well.}, author = {Puglia, Denise and Martinez, Esteban and Menard, Gerbold and Pöschl, Andreas and Gronin, Sergei and Gardner, Geoffrey and Kallaher, Ray and Manfra, Michael and Marcus, Charles and Higginbotham, Andrew P and Casparis, Lucas}, publisher = {Zenodo}, title = {{Data for 'Closing of the Induced Gap in a Hybrid Superconductor-Semiconductor Nanowire}}, doi = {10.5281/ZENODO.4592435}, year = {2021}, } @inproceedings{13146, abstract = {A recent line of work has analyzed the theoretical properties of deep neural networks via the Neural Tangent Kernel (NTK). In particular, the smallest eigenvalue of the NTK has been related to the memorization capacity, the global convergence of gradient descent algorithms and the generalization of deep nets. However, existing results either provide bounds in the two-layer setting or assume that the spectrum of the NTK matrices is bounded away from 0 for multi-layer networks. In this paper, we provide tight bounds on the smallest eigenvalue of NTK matrices for deep ReLU nets, both in the limiting case of infinite widths and for finite widths. In the finite-width setting, the network architectures we consider are fairly general: we require the existence of a wide layer with roughly order of N neurons, N being the number of data samples; and the scaling of the remaining layer widths is arbitrary (up to logarithmic factors). To obtain our results, we analyze various quantities of independent interest: we give lower bounds on the smallest singular value of hidden feature matrices, and upper bounds on the Lipschitz constant of input-output feature maps.}, author = {Nguyen, Quynh and Mondelli, Marco and Montufar, Guido}, booktitle = {Proceedings of the 38th International Conference on Machine Learning}, isbn = {9781713845065}, issn = {2640-3498}, location = {Virtual}, pages = {8119--8129}, publisher = {ML Research Press}, title = {{Tight bounds on the smallest Eigenvalue of the neural tangent kernel for deep ReLU networks}}, volume = {139}, year = {2021}, }