@article{15264,
abstract = {Signaling by the B cell antigen receptor (BCR) initiates actin remodeling. The assembly of branched actin networks that are nucleated by the Arp2/3 complex exert outward force on the plasma membrane, allowing B cells to form membrane protrusions that can scan the surface of antigen-presenting cells (APCs). The resulting Arp2/3 complex-dependent actin retrograde flow promotes the centripetal movement and progressive coalescence of BCR microclusters, which amplifies BCR signaling. Glia maturation factor γ (GMFγ) is an actin disassembly-protein that releases Arp2/3 complex-nucleated actin filaments from actin networks. By doing so, GMFγ could either oppose the actions of the Arp2/3 complex or support Arp2/3 complex-nucleated actin polymerization by contributing to the recycling of actin monomers and Arp2/3 complexes. We now show that reducing the levels of GMFγ in human B cell lines via transfection with a specific siRNA impairs the ability of B cells to spread on antigen-coated surfaces, decreases the velocity of actin retrograde flow, diminishes the coalescence of BCR microclusters into a central cluster at the B cell-APC contact site, and decreases APC-induced BCR signaling. These effects of depleting GMFγ are similar to what occurs when the Arp2/3 complex is inhibited. This suggests that GMFγ cooperates with the Arp2/3 complex to support BCR-induced actin remodeling and amplify BCR signaling at the immune synapse.},
author = {Deretic, Nikola and Bolger-Munro, Madison and Choi, Kate and Abraham, Libin and Gold, Michael R.},
issn = {2296-634X},
journal = {Frontiers in Cell and Developmental Biology},
keywords = {Cell Biology, Developmental Biology},
publisher = {Frontiers Media},
title = {{The actin-disassembly protein glia maturation factor γ enhances actin remodeling and B cell antigen receptor signaling at the immune synapse}},
doi = {10.3389/fcell.2021.647063},
volume = {9},
year = {2021},
}
@article{15265,
abstract = {The highly enhanced thermoelectric figure of merit, zT ≈ 2.6 at 573 K, obtained recently in Cd-doped polycrystalline AgSbTe2 by Roychowdhury et al. ( Science 2021, 371, 722) brings it to the forefront of thermoelectric and energy materials research. Ag/Sb cationic ordering in polycrystalline AgSbTe2 was a challenging issue for a long time: their ordered arrangement in the cationic sublattice in polycrystalline samples remained elusive despite multiple theoretical predictions and experimental studies. Recently, selective cation doping has been used to enhance the Ag/Sb ordering, and cation ordered nanoscale (2–4 nm) domains were observed in polycrystalline AgSbTe2, which reduce lattice thermal conductivity. The enhanced cation ordering also delocalizes disorder-induced localized electronic states, and consequently the electronic transport enhances. In this Focus Review, we provide the details of the rational design of a high-performance thermoelectric material using the recently developed atomic order–disorder optimization strategy with AgSbTe2 as an example. Atomic disorder is ubiquitous in most thermoelectric materials, and the atomic order–disorder optimization strategy applies to a large variety of thermoelectric materials.},
author = {Ghosh, Tanmoy and Roychowdhury, Subhajit and Dutta, Moinak and Biswas, Kanishka},
issn = {2380-8195},
journal = {ACS Energy Letters},
keywords = {Materials Chemistry, Energy Engineering and Power Technology, Fuel Technology, Renewable Energy, Sustainability and the Environment, Chemistry (miscellaneous)},
number = {8},
pages = {2825--2837},
publisher = {American Chemical Society},
title = {{High-performance thermoelectric energy conversion: A tale of atomic ordering in AgSbTe2}},
doi = {10.1021/acsenergylett.1c01184},
volume = {6},
year = {2021},
}
@article{15266,
abstract = {Plant pathogens often exploit a whole range of effectors to facilitate infection. The RXLR effector AVR1 produced by the oomycete plant pathogen Phytophthora infestans suppresses host defense by targeting Sec5. Sec5 is a subunit of the exocyst, a protein complex that is important for mediating polarized exocytosis during plant development and defense against pathogens. The mechanism by which AVR1 manipulates Sec5 functioning is unknown. In this study, we analyzed the effect of AVR1 on Sec5 localization and functioning in the moss Physcomitrium patens. P. patens has four Sec5 homologs. Two (PpSec5b and PpSec5d) were found to interact with AVR1 in yeast-two-hybrid assays while none of the four showed a positive interaction with AVR1ΔT, a truncated version of AVR1. In P. patens lines carrying β-estradiol inducible AVR1 or AVR1ΔT transgenes, expression of AVR1 or AVR1ΔT caused defects in the development of caulonemal protonema cells and abnormal morphology of chloronema cells. Similar phenotypes were observed in Sec5- or Sec6-silenced P. patens lines, suggesting that both AVR1 and AVR1ΔT affect exocyst functioning in P. patens. With respect to Sec5 localization we found no differences between β-estradiol-treated and untreated transgenic AVR1 lines. Sec5 localizes at the plasma membrane in growing caulonema cells, also during pathogen attack, and its subcellular localization is the same, with or without AVR1 in the vicinity.},
author = {Overdijk, Elysa J. R. and Putker, Vera and Smits, Joep and Tang, Han and Bouwmeester, Klaas and Govers, Francine and Ketelaar, Tijs},
issn = {1932-6203},
journal = {PLoS One},
keywords = {Multidisciplinary},
number = {4},
publisher = {Public Library of Science},
title = {{Phytophthora infestans RXLR effector AVR1 disturbs the growth of Physcomitrium patens without affecting Sec5 localization}},
doi = {10.1371/journal.pone.0249637},
volume = {16},
year = {2021},
}
@article{15267,
abstract = {We study two fundamental communication primitives: broadcasting and leader election in the classical model of multi-hop radio networks with unknown topology and without collision detection mechanisms. It has been known for almost 20 years that in undirected networks with n nodes and diameter D, randomized broadcasting requires Ω(D log n/D + log2 n) rounds, assuming that uninformed nodes are not allowed to communicate (until they are informed). Only very recently, Haeupler and Wajc (PODC'2016) showed that this bound can be improved for the model with spontaneous transmissions, providing an O(D log n log log n/log D + logO(1) n)-time broadcasting algorithm. In this article, we give a new and faster algorithm that completes broadcasting in O(D log n/log D + logO(1) n) time, succeeding with high probability. This yields the first optimal O(D)-time broadcasting algorithm whenever n is polynomial in D.
Furthermore, our approach can be applied to design a new leader election algorithm that matches the performance of our broadcasting algorithm. Previously, all fast randomized leader election algorithms have used broadcasting as a subroutine and their complexity has been asymptotically strictly larger than the complexity of broadcasting. In particular, the fastest previously known randomized leader election algorithm of Ghaffari and Haeupler (SODA'2013) requires O(D log n/D min {log log n, log n/D} + logO(1) n)-time, succeeding with high probability. Our new algorithm again requires O(D log n/log D + logO(1) n) time, also succeeding with high probability.},
author = {Czumaj, Artur and Davies, Peter},
issn = {1557-735X},
journal = {Journal of the ACM},
keywords = {Artificial Intelligence, Hardware and Architecture, Information Systems, Control and Systems Engineering, Software},
number = {2},
publisher = {Association for Computing Machinery},
title = {{Exploiting spontaneous transmissions for broadcasting and leader election in radio networks}},
doi = {10.1145/3446383},
volume = {68},
year = {2021},
}
@article{15269,
abstract = {We study different aspects of quantum field theory at finite density using methods from quantum information theory. For simplicity we focus on massive Dirac fermions with nonzero chemical potential, and work in 1 + 1 space-time dimensions. Using the entanglement entropy on an interval, we construct an entropic c-function that is finite. Unlike what happens in Lorentz-invariant theories, this c-function exhibits a strong violation of monotonicity; it also encodes the creation of long-range entanglement from the Fermi surface. Motivated by previous works on lattice models, we next calculate numerically the Renyi entropies and find Friedel-type oscillations; these are understood in terms of a defect operator product expansion. Furthermore, we consider the mutual information as a measure of correlation functions between different regions. Using a long-distance expansion previously developed by Cardy, we argue that the mutual information detects Fermi surface correlations already at leading order in the expansion. We also analyze the relative entropy and its Renyi generalizations in order to distinguish states with different charge and/or mass. In particular, we show that states in different superselection sectors give rise to a super-extensive behavior in the relative entropy. Finally, we discuss possible extensions to interacting theories, and argue for the relevance of some of these measures for probing non-Fermi liquids.},
author = {Daguerre, Lucas and Medina Ramos, Raimel A and Solís, Mario and Torroba, Gonzalo},
issn = {1029-8479},
journal = {Journal of High Energy Physics},
keywords = {Nuclear and High Energy Physics},
number = {3},
publisher = {Springer Nature},
title = {{Aspects of quantum information in finite density field theory}},
doi = {10.1007/jhep03(2021)079},
volume = {2021},
year = {2021},
}
@article{15270,
abstract = {Various toxic compounds disrupt bacterial physiology. While bacteria harbor defense mechanisms to mitigate the toxicity, these mechanisms are often coupled to the physiological state of the cells and become ineffective when the physiology is severely disrupted.},
author = {Le, Dai and Krasnopeeva, Ekaterina and Sinjab, Faris and Pilizota, Teuta and Kim, Minsu},
issn = {2150-7511},
journal = {mBio},
keywords = {Virology, Microbiology},
number = {4},
publisher = {American Society for Microbiology},
title = {{Active efflux leads to heterogeneous dissipation of proton motive force by protonophores in bacteria}},
doi = {10.1128/mbio.00676-21},
volume = {12},
year = {2021},
}
@article{15271,
abstract = {We settle the complexity of the (∆ + 1)-coloring and (∆ + 1)-list coloring problems intheCONGESTED CLIQUEmodel by presenting a simpledeterministicalgorithm for both problemsrunning in a constant number of rounds. This matches the complexity of the recent breakthroughrandomizedconstant-round (∆ + 1)-list coloring algorithm due to Chang et al. [Proceedings of the38th ACM Symposium on Principles of Distributed Computing, 2019] and significantly improvesupon the state-of-the-artO(log ∆)-round deterministic (∆ + 1)-coloring bound of Parter [Proceed-ings of the 45th Annual International Colloquium on Automata, Languages and Programming]. Aremarkable property of our algorithm is its simplicity. Whereas the state-of-the-artrandomizedal-gorithms for this problem are based on the quite involved local coloring algorithm of Chang, Li, andPettie [Proceedings of the 50th Annual ACM SIGACT Symposium on Theory of Computing, 2018],our algorithm can be described in just a few lines. At a high level, it applies a careful derandomiza-tion of a recursive procedure which partitions the nodes and their respective palettes into separatebins. We show that afterO(1) recursion steps, the remaining uncolored subgraph within each bin haslinear size and thus can be solved locally by collecting it to a single node. This algorithm can alsobe implemented in the massively parallel computation (MPC) model provided that each machine haslinear (inn, the number of nodes in the input graph) space. We also show an extension of our algo-rithm to theMPCregime, in which machines havesublinearspace: we present the first deterministic(∆ + 1)-list coloring algorithm designed for sublinear-spaceMPC, which runs inO(log ∆ + log logn)rounds.},
author = {Czumaj, Artur and Davies, Peter and Parter, Merav},
issn = {1095-7111},
journal = {SIAM Journal on Computing},
keywords = {General Mathematics, General Computer Science},
number = {5},
pages = {1603--1626},
publisher = {Society for Industrial and Applied Mathematics},
title = {{Simple, deterministic, constant-round coloring in congested clique and MPC}},
doi = {10.1137/20m1366502},
volume = {50},
year = {2021},
}
@article{15272,
abstract = {The assembly of neuronal circuits involves the migrations of neurons from their place of birth to their final location in the nervous system, as well as the coordinated growth and patterning of axons and dendrites. In screens for genes required for patterning of the nervous system, we identified the catp-8/P5A-ATPase as an important regulator of neural patterning. P5A-ATPases are part of the P-type ATPases, a family of proteins known to serve a conserved function as transporters of ions, lipids and polyamines in unicellular eukaryotes, plants, and humans. While the function of many P-type ATPases is relatively well understood, the function of P5A-ATPases in metazoans remained elusive. We show here, that the Caenorhabditis elegans ortholog catp-8/P5A-ATPase is required for defined aspects of nervous system development. Specifically, the catp-8/P5A-ATPase serves functions in shaping the elaborately sculpted dendritic trees of somatosensory PVD neurons. Moreover, catp-8/P5A-ATPase is required for axonal guidance and repulsion at the midline, as well as embryonic and postembryonic neuronal migrations. Interestingly, not all axons at the midline require catp-8/P5A-ATPase, although the axons run in the same fascicles and navigate the same space. Similarly, not all neuronal migrations require catp-8/P5A-ATPase. A CATP-8/P5A-ATPase reporter is localized to the ER in most, if not all, tissues and catp-8/P5A-ATPase can function both cell-autonomously and non-autonomously to regulate neuronal development. Genetic analyses establish that catp-8/P5A-ATPase can function in multiple pathways, including the Menorin pathway, previously shown to control dendritic patterning in PVD, and Wnt signaling, which functions to control neuronal migrations. Lastly, we show that catp-8/P5A-ATPase is required for localizing select transmembrane proteins necessary for dendrite morphogenesis. Collectively, our studies suggest that catp-8/P5A-ATPase serves diverse, yet specific, roles in different genetic pathways and may be involved in the regulation or localization of transmembrane and secreted proteins to specific subcellular compartments.},
author = {Tang, Leo T. H. and Trivedi, Meera and Freund, Jenna and Salazar, Christopher J. and Rahman, Maisha and Ramirez, Nelson and Lee, Garrett and Wang, Yu and Grant, Barth D. and Bülow, Hannes E.},
issn = {1553-7404},
journal = {PLOS Genetics},
keywords = {Cancer Research, Genetics (clinical), Genetics, Molecular Biology, Ecology, Evolution, Behavior and Systematics},
number = {7},
publisher = {Public Library of Science},
title = {{The CATP-8/P5A-type ATPase functions in multiple pathways during neuronal patterning}},
doi = {10.1371/journal.pgen.1009475},
volume = {17},
year = {2021},
}
@article{15273,
abstract = {Synapses of glutamatergic mossy fibers (MFs) onto cerebellar unipolar brush cells (UBCs) generate slow excitatory (ON) or inhibitory (OFF) postsynaptic responses dependent on the complement of glutamate receptors expressed on the UBC’s large dendritic brush. Using mouse brain slice recording and computational modeling of synaptic transmission, we found that substantial glutamate is maintained in the UBC synaptic cleft, sufficient to modify spontaneous firing in OFF UBCs and tonically desensitize AMPARs of ON UBCs. The source of this ambient glutamate was spontaneous, spike-independent exocytosis from the MF terminal, and its level was dependent on activity of glutamate transporters EAAT1–2. Increasing levels of ambient glutamate shifted the polarity of evoked synaptic responses in ON UBCs and altered the phase of responses to in vivo-like synaptic activity. Unlike classical fast synapses, receptors at the UBC synapse are virtually always exposed to a significant level of glutamate, which varies in a graded manner during transmission.},
author = {Balmer, Timothy S and Borges Merjane, Carolina and Trussell, Laurence O},
issn = {2050-084X},
journal = {eLife},
keywords = {General Immunology and Microbiology, General Biochemistry, Genetics and Molecular Biology, General Medicine, General Neuroscience},
publisher = {eLife Sciences Publications},
title = {{Incomplete removal of extracellular glutamate controls synaptic transmission and integration at a cerebellar synapse}},
doi = {10.7554/elife.63819},
volume = {10},
year = {2021},
}
@article{15274,
abstract = {Copper (Cu) is a redox-active micronutrient that is both essential and toxic. Its cellular homeostasis is critical for supporting cuproprotein maturation while avoiding excessive oxidative stress. The Cu importer CcoA is the prototype of the widespread CalT subfamily of the MFS-type transporters. Hence, understanding its molecular mechanism of function is significant. Here, we show that CcoA undergoes a thiol:disulfide oxidoreduction cycle, which is important for its Cu import activity.},
author = {Khalfaoui-Hassani, Bahia and Trasnea, Petru Iulian and Steimle, Stefan and Koch, Hans-Georg and Daldal, Fevzi},
issn = {2150-7511},
journal = {mBio},
keywords = {Virology, Microbiology},
number = {4},
publisher = {American Society for Microbiology},
title = {{Cysteine mutants of the major facilitator superfamily-type transporter CcoA provide insight into copper import}},
doi = {10.1128/mbio.01567-21},
volume = {12},
year = {2021},
}
@article{15275,
abstract = {In 1916, Schur introduced the Ramsey number r(3; m), which is the minimum integer n > 1 such that for any m-coloring of the edges of the complete graph Kn, there is a monochromatic copy of K3. He showed that r(3; m) ≤ O(m!), and a simple construction demonstrates that r(3; m) ≥ 2Ω(m). An old conjecture of Erdős states that r(3; m) = 2Θ(m). In this note, we prove the conjecture for m-colorings with bounded VC-dimension, that is, for m-colorings with the property that the set system induced by the neighborhoods of the vertices with respect to each color class has bounded VC-dimension.},
author = {Fox, Jacob and Pach, János and Suk, Andrew},
issn = {1439-6912},
journal = {Combinatorica},
keywords = {Computational Mathematics, Discrete Mathematics and Combinatorics},
number = {6},
pages = {803--813},
publisher = {Springer Nature},
title = {{Bounded VC-dimension implies the Schur-Erdős conjecture}},
doi = {10.1007/s00493-021-4530-9},
volume = {41},
year = {2021},
}
@article{15276,
abstract = {Biotrophic plant pathogens secrete effector proteins to manipulate the host physiology. Effectors suppress defenses and induce an environment favorable to disease development. Sequence-based prediction of effector function is impeded by their rapid evolution rate. In the maize pathogen Ustilago maydis, effector-coding genes frequently organize in clusters. Here we describe the functional characterization of the pleiades, a cluster of ten effector genes, by analyzing the micro- and macroscopic phenotype of the cluster deletion and expressing these proteins in planta. Deletion of the pleiades leads to strongly impaired virulence and accumulation of reactive oxygen species (ROS) in infected tissue. Eight of the Pleiades suppress the production of ROS upon perception of pathogen associated molecular patterns (PAMPs). Although functionally redundant, the Pleiades target different host components. The paralogs Taygeta1 and Merope1 suppress ROS production in either the cytoplasm or nucleus, respectively. Merope1 targets and promotes the auto-ubiquitination activity of RFI2, a conserved family of E3 ligases that regulates the production of PAMP-triggered ROS burst in plants.},
author = {Navarrete, Fernando and Grujic, Nenad and Stirnberg, Alexandra and Saado, Indira and Aleksza, David and Gallei, Michelle C and Adi, Hazem and Alcântara, André and Khan, Mamoona and Bindics, Janos and Trujillo, Marco and Djamei, Armin},
issn = {1553-7374},
journal = {PLOS Pathogens},
keywords = {Virology, Genetics, Molecular Biology, Immunology, Microbiology, Parasitology},
number = {6},
publisher = {Public Library of Science},
title = {{The Pleiades are a cluster of fungal effectors that inhibit host defenses}},
doi = {10.1371/journal.ppat.1009641},
volume = {17},
year = {2021},
}
@article{15277,
abstract = {Alternative splicing generates multiple transcript and protein isoforms from a single gene and controls transcript intracellular localization and stability by coupling to mRNA export and nonsense-mediated mRNA decay (NMD). RNA interference (RNAi) is a potent mechanism to modulate gene expression. However, its interactions with alternative splicing are poorly understood. We used artificial microRNAs (amiRNAs, also termed shRNAmiR) to knockdown all splice variants of selected target genes in Arabidopsis thaliana. We found that splice variants, which vary by their protein-coding capacity, subcellular localization and sensitivity to NMD, are affected differentially by an amiRNA, although all of them contain the target site. Particular transcript isoforms escape amiRNA-mediated degradation due to their nuclear localization. The nuclear and NMD-sensitive isoforms mask RNAi action in alternatively spliced genes. Interestingly, Arabidopsis SPL genes, which undergo alternative splicing and are targets of miR156, are regulated in the same manner. Moreover, similar results were obtained in mammalian cells using siRNAs, indicating cross-kingdom conservation of these interactions among RNAi and splicing isoforms. Furthermore, we report that amiRNA can trigger artificial alternative splicing, thus expanding the RNAi functional repertoire. Our findings unveil novel interactions between different post-transcriptional processes in defining transcript fates and regulating gene expression.},
author = {Fuchs, Armin and Riegler, Stefan and Ayatollahi, Zahra and Cavallari, Nicola and Giono, Luciana E and Nimeth, Barbara A and Mutanwad, Krishna V and Schweighofer, Alois and Lucyshyn, Doris and Barta, Andrea and Petrillo, Ezequiel and Kalyna, Maria},
issn = {1362-4962},
journal = {Nucleic Acids Research},
keywords = {Genetics},
number = {2},
pages = {1133--1151},
publisher = {Oxford University Press},
title = {{Targeting alternative splicing by RNAi: From the differential impact on splice variants to triggering artificial pre-mRNA splicing}},
doi = {10.1093/nar/gkaa1260},
volume = {49},
year = {2021},
}
@article{15278,
abstract = {‘Dysbiosis’ of the adult gut microbiota, in response to challenges such as infection, altered diet, stress, and antibiotics treatment has been recently linked to pathological alteration of brain function and behavior. Moreover, gut microbiota composition constantly controls microglia maturation, as revealed by morphological observations and gene expression analysis. However, it is unclear whether microglia functional properties and crosstalk with neurons, known to shape and modulate synaptic development and function, are influenced by the gut microbiota. Here, we investigated how antibiotic-mediated alteration of the gut microbiota influences microglial and neuronal functions in adult mice hippocampus. Hippocampal microglia from adult mice treated with oral antibiotics exhibited increased microglia density, altered basal patrolling activity, and impaired process rearrangement in response to damage. Patch clamp recordings at CA3-CA1 synapses revealed that antibiotics treatment alters neuronal functions, reducing spontaneous postsynaptic glutamatergic currents and decreasing synaptic connectivity, without reducing dendritic spines density. Antibiotics treatment was unable to modulate synaptic function in CX3CR1-deficient mice, pointing to an involvement of microglia–neuron crosstalk through the CX3CL1/CX3CR1 axis in the effect of dysbiosis on neuronal functions. Together, our findings show that antibiotic alteration of gut microbiota impairs synaptic efficacy, suggesting that CX3CL1/CX3CR1 signaling supporting microglia is a major player in in the gut–brain axis, and in particular in the gut microbiota-to-neuron communication pathway.},
author = {Cordella, Federica and Sanchini, Caterina and Rosito, Maria and Ferrucci, Laura and Pediconi, Natalia and Cortese, Barbara and Guerrieri, Francesca and Pascucci, Giuseppe Rubens and Antonangeli, Fabrizio and Peruzzi, Giovanna and Giubettini, Maria and Basilico, Bernadette and Pagani, Francesca and Grimaldi, Alfonso and D’Alessandro, Giuseppina and Limatola, Cristina and Ragozzino, Davide and Di Angelantonio, Silvia},
issn = {2073-4409},
journal = {Cells},
keywords = {General Medicine},
number = {10},
publisher = {MDPI},
title = {{Antibiotics treatment modulates microglia–synapses interaction}},
doi = {10.3390/cells10102648},
volume = {10},
year = {2021},
}
@article{15279,
abstract = {We formulate and prove an analog of Poonen’s finite-field Bertini theorem with Taylor conditions that holds in the Grothendieck ring of varieties. This gives a broad generalization of the work of Vakil and Wood, who treated the case of smooth hypersurface sections, and is made possible by the use of motivic Euler products to write down candidate motivic probabilities. As applications, we give motivic analogs of many results in arithmetic statistics that have been proven using Poonen’s sieve, including work of Bucur and Kedlaya on complete intersections and Erman and Wood on semiample Bertini theorems.},
author = {Bilu, Margaret and Howe, Sean},
issn = {1944-7833},
journal = {Algebra & Number Theory},
keywords = {Algebra and Number Theory},
number = {9},
pages = {2195--2259},
publisher = {Mathematical Sciences Publishers},
title = {{Motivic Euler products in motivic statistics}},
doi = {10.2140/ant.2021.15.2195},
volume = {15},
year = {2021},
}
@inproceedings{15280,
author = {Balazs, Daniel and Cimada da Silva, Jessica and Dunbar, Tyler and Ibáñez, Maria and Hanrath, Tobias},
booktitle = {Proceedings of the Internet NanoGe Conference on Nanocrystals},
location = {Virtual},
publisher = {Fundació Scito},
title = {{Controlled reactive assembly of colloidal nanocrystal superlattices: Mechanism and kinetics}},
doi = {10.29363/nanoge.incnc.2021.050},
year = {2021},
}
@article{15283,
author = {Nicolas, William and Fäßler, Florian and Meyerowitz, Elliot and Jensen, Grant},
issn = {1435-8115},
journal = {Microscopy and Microanalysis},
keywords = {Instrumentation},
number = {S1},
pages = {3024--3026},
publisher = {Oxford University Press},
title = {{Peaking into the plant cell wall using cryo-FIB milling and electron cryo-tomography}},
doi = {10.1017/s1431927621010503},
volume = {27},
year = {2021},
}
@misc{15284,
abstract = {RevTerm is a static analysis tool for proving non-termination of integer C programs (possibly with non-determinism). RevTerm is an implementation of our method for non-termination proving presented in the paper “Proving Non-termination by Program Reversal”.
},
author = {Chatterjee, Krishnendu and Goharshady, Ehsan Kafshdar and Novotný, Petr and Zikelic, Dorde},
publisher = {Association for Computing Machinery},
title = {{RevTerm}},
doi = {10.1145/3410304},
year = {2021},
}
@article{15285,
abstract = {Ever since the first publication of the standard communication protocol for computer-assisted electrocardiography (SCP-ECG), prENV 1064, in 1993, by the European Committee for Standardization (CEN), SCP-ECG has become a leading example in health informatics, enabling open, secure, and well-documented digital data exchange at a low cost, for quick and efficient cardiovascular disease detection and management. Based on the experiences gained, since the 1970s, in computerized electrocardiology, and on the results achieved by the pioneering, international cooperative research on common standards for quantitative electrocardiography (CSE), SCP-ECG was designed, from the beginning, to empower personalized medicine, thanks to serial ECG analysis. The fundamental concept behind SCP-ECG is to convey the necessary information for ECG re-analysis, serial comparison, and interpretation, and to structure the ECG data and metadata in sections that are mostly optional in order to fit all use cases. SCP-ECG is open to the storage of the ECG signal and ECG measurement data, whatever the ECG recording modality or computation method, and can store the over-reading trails and ECG annotations, as well as any computerized or medical interpretation reports. Only the encoding syntax and the semantics of the ECG descriptors and of the diagnosis codes are standardized. We present all of the landmarks in the development and publication of SCP-ECG, from the early 1990s to the 2009 International Organization for Standardization (ISO) SCP-ECG standards, including the latest version published by CEN in 2020, which now encompasses rest and stress ECGs, Holter recordings, and protocol-based trials.},
author = {Rubel, Paul and Fayn, Jocelyne and Macfarlane, Peter W. and Pani, Danilo and Schlögl, Alois and Värri, Alpo},
issn = {2673-3846},
journal = {Hearts},
keywords = {General Medicine},
number = {3},
pages = {384--409},
publisher = {MDPI},
title = {{The history and challenges of SCP-ECG: The standard communication protocol for computer-assisted electrocardiography}},
doi = {10.3390/hearts2030031},
volume = {2},
year = {2021},
}
@inproceedings{10552,
abstract = {We study a class of convex-concave saddle-point problems of the form minxmaxy⟨Kx,y⟩+fP(x)−h∗(y) where K is a linear operator, fP is the sum of a convex function f with a Lipschitz-continuous gradient and the indicator function of a bounded convex polytope P, and h∗ is a convex (possibly nonsmooth) function. Such problem arises, for example, as a Lagrangian relaxation of various discrete optimization problems. Our main assumptions are the existence of an efficient linear minimization oracle (lmo) for fP and an efficient proximal map for h∗ which motivate the solution via a blend of proximal primal-dual algorithms and Frank-Wolfe algorithms. In case h∗ is the indicator function of a linear constraint and function f is quadratic, we show a O(1/n2) convergence rate on the dual objective, requiring O(nlogn) calls of lmo. If the problem comes from the constrained optimization problem minx∈Rd{fP(x)|Ax−b=0} then we additionally get bound O(1/n2) both on the primal gap and on the infeasibility gap. In the most general case, we show a O(1/n) convergence rate of the primal-dual gap again requiring O(nlogn) calls of lmo. To the best of our knowledge, this improves on the known convergence rates for the considered class of saddle-point problems. We show applications to labeling problems frequently appearing in machine learning and computer vision.},
author = {Kolmogorov, Vladimir and Pock, Thomas},
booktitle = {38th International Conference on Machine Learning},
location = {Virtual},
title = {{One-sided Frank-Wolfe algorithms for saddle problems}},
year = {2021},
}