@article{9999,
  abstract     = {The developmental strategies used by progenitor cells to endure a safe journey from their induction place towards the site of terminal differentiation are still poorly understood. Here we uncovered a progenitor cell allocation mechanism that stems from an incomplete process of epithelial delamination that allows progenitors to coordinate their movement with adjacent extra-embryonic tissues. Progenitors of the zebrafish laterality organ originate from the surface epithelial enveloping layer by an apical constriction process of cell delamination. During this process, progenitors retain long-term apical contacts that enable the epithelial layer to pull a subset of progenitors along their way towards the vegetal pole. The remaining delaminated progenitors follow apically-attached progenitors’ movement by a co-attraction mechanism, avoiding sequestration by the adjacent endoderm, ensuring their fate and collective allocation at the differentiation site. Thus, we reveal that incomplete delamination serves as a cellular platform for coordinated tissue movements during development. Impact Statement: Incomplete delamination serves as a cellular platform for coordinated tissue movements during development, guiding newly formed progenitor cell groups to the differentiation site.},
  author       = {Pulgar, Eduardo and Schwayer, Cornelia and Guerrero, Néstor and López, Loreto and Márquez, Susana and Härtel, Steffen and Soto, Rodrigo and Heisenberg, Carl Philipp and Concha, Miguel L.},
  issn         = {2050-084X},
  journal      = {eLife},
  keywords     = {cell delamination, apical constriction, dragging, mechanical forces, collective 18 locomotion, dorsal forerunner cells, zebrafish},
  publisher    = {eLife Sciences Publications},
  title        = {{Apical contacts stemming from incomplete delamination guide progenitor cell allocation through a dragging mechanism}},
  doi          = {10.7554/eLife.66483},
  volume       = {10},
  year         = {2021},
}

@article{21805,
  abstract     = {Donor–acceptor Stenhouse adducts (DASAs) are visible‐light‐responsive photoswitches with a variety of emerging applications in photoresponsive materials. Their two‐step modular synthesis, centered on the nucleophilic ring opening of an activated furan, makes DASAs readily accessible. However, the use of less reactive donors or acceptors renders the process slow and low yielding, which has limited their development. We demonstrate here that 1,1,1,3,3,3‐hexafluoro‐2‐propanol (HFIP) promotes the ring‐opening reaction and stabilizes the open isomer, allowing greatly reduced reaction times and increased yields for known derivatives. In addition, it provides access to previously unattainable DASA‐based photoswitches and DASA–polymer conjugates. The role of HFIP and the photochromic properties of a set of new DASAs is probed using a combination of <jats:sup>1</jats:sup>H NMR and UV/Vis spectroscopy. The use of sterically hindered, electron‐poor amines enabled the dark equilibrium to be decoupled from closed‐isomer half‐lives for the first time.},
  author       = {Clerc, Michèle and Stricker, Friedrich J and Ulrich, Sebastian and Sroda, Miranda and Bruns, Nico and Boesel, Luciano F. and Read de Alaniz, Javier},
  issn         = {1521-3773},
  journal      = {Angewandte Chemie International Edition},
  number       = {18},
  pages        = {10219--10227},
  publisher    = {Wiley},
  title        = {{Promoting the furan ring‐opening reaction to access new donor-acceptor Stenhouse adducts with hexafluoroisopropanol}},
  doi          = {10.1002/anie.202100115},
  volume       = {60},
  year         = {2021},
}

@article{21808,
  abstract     = {A convenient approach for the synthesis of foldable redox-active flavin peptide conjugates was established. A model β-hairpin oligopeptide motif was utilized to demonstrate that azidolysine side-chains are readily functionalised with an alkyne-bearing flavine derivative. The folding equilibrium of the peptide backbone as well as the redox behaviour of the flavin moieties remains intact after the conjugation.},
  author       = {Stricker, Friedrich J and Kölsch, Jonas Christopher and Beil, Sebastian B. and Preiß, Sebastian and Waldvogel, Siegfried R. and Opatz, Till and Besenius, Pol},
  issn         = {1477-0539},
  journal      = {Organic & Biomolecular Chemistry},
  number       = {20},
  pages        = {4483--4486},
  publisher    = {Royal Society of Chemistry},
  title        = {{Facile access to foldable redox-active flavin-peptide conjugates}},
  doi          = {10.1039/d1ob00414j},
  volume       = {19},
  year         = {2021},
}

@article{21811,
  abstract     = {The effects of solution‐state dielectric and intermolecular interactions on the degree of charge separation provide a route to understanding the switching properties and concentration dependence of donor–acceptor Stenhouse adducts (DASAs). Through solvatochromic analysis of the open‐form DASA in conjunction with X‐ray diffraction and computational theory, we have analyzed the ionic character of a series of DASAs. First‐ and third‐generation architectures lead to a higher zwitterionic resonance contribution of the open form and a zwitterionic closed form, whereas the second‐generation architecture possesses a less charge‐separated open form and neutral closed form. This can be correlated with equilibrium control and photoswitching solvent compatibility. As a result of the high contribution of the zwitterionic resonance forms of first‐ and third‐generation DASAs, we were able to control their switching kinetics by means of ion concentration, whereas second‐generation DASAs were less affected. Importantly, these results show how the previously reported concentration dependence of DASAs is not universal, and that DASAs with a more hybrid structure in the open form can achieve photoswitching at high concentrations.},
  author       = {Sroda, Miranda M. and Stricker, Friedrich J and Peterson, Julie A. and Bernal, Alexandria and Read de Alaniz, Javier},
  issn         = {1521-3765},
  journal      = {Chemistry - A European Journal},
  number       = {12},
  pages        = {4183--4190},
  publisher    = {Wiley},
  title        = {{Donor–acceptor Stenhouse adducts: Exploring the effects of ionic character}},
  doi          = {10.1002/chem.202005110},
  volume       = {27},
  year         = {2021},
}

@article{21816,
  abstract     = {A new Diels−Alder (DA)-based photopatterning platform is presented, which exploits the irreversible, light-induced decarbonylation and subsequent cleavage of cyclopentadienone−norbornadiene (CPD−NBD) adducts. A series of CPD−NBD adducts have been prepared and systematically studied toward the use in a polymeric material photopatterning platform. By incorporating an optimized CPD−NBD adduct into polymer networks, it is demonstrated that cyclopentadiene may be unveiled upon 365 nm irradiation and subsequently clicked to a variety of maleimides with spatial control under mild reaction conditions and with fast kinetics. Unlike currently available photoinduced Diels−Alder reactions that rely on trapping transient, photocaged dienes, this platform introduces a persistent, yet highly reactive diene after irradiation, enabling the use of photosensitive species such as cyanine dyes to be patterned. To highlight the potential use of this platform in a variety of material applications, we demonstrate two proof-of-concepts: patterned conjugation of multiple dyes into apolyacrylate network and preprogrammed ligation of streptavidin into poly(ethylene glycol) hydrogels.},
  author       = {Bailey, Sophia J. and Stricker, Friedrich J and Hopkins, Erik and Wilson, Maxwell Z. and Read de Alaniz, Javier},
  issn         = {1944-8252},
  journal      = {ACS Applied Materials & Interfaces},
  keywords     = {click chemistry, Diels−Alder, cyclopentadiene, photochemistry, photopatterning},
  number       = {30},
  pages        = {35422--35430},
  publisher    = {American Chemical Society},
  title        = {{Shining light on cyclopentadienone–norbornadiene Diels-Alder adducts to enable photoinduced click chemistry with cyclopentadiene}},
  doi          = {10.1021/acsami.1c08670},
  volume       = {13},
  year         = {2021},
}

@article{21820,
  abstract     = {Photosurfactants have shown considerable promise for enabling stimuli-responsive control of the properties and motion of fluid interfaces. Recently, a number of photoswitch chemistries have emerged to tailor the photoresponsive properties of photosurfactants. However, systematic studies investigating how photoresponsive surfactant behavior depends on the photochemical and photophysical properties of the switch remain scarce. In this work, we develop synthetic schemes and surfactant designs to produce a well-controlled library of photosurfactants to comparatively assess the behavior of photoswitch chemistry on interfacial behavior. We employ photoinduced spreading of droplets at fluid interfaces as a model for such studies. We show that although photosurfactant response is largely guided by expected trends with changes in polarity of the photoswitch, interfacial behavior also depends nontrivially and sometimes counter-intuitively on the kinetics and mechanisms of photoswitching, particularly at the interface of two solvents, as well as on complex interactions with other surfactants. Understanding these complexities enables the design of new photosurfactant systems and their optimization toward responsive functions including triggered spreading, dewetting, and destabilization of droplets on solid and fluid surfaces.},
  author       = {Seshadri, Serena and Bailey, Sophia J. and Zhao, Lei and Fisher, Julia and Sroda, Miranda and Chiu, Michelle and Stricker, Friedrich J and Valentine, Megan T. and Read de Alaniz, Javier and Helgeson, Matthew E.},
  issn         = {1520-5827},
  journal      = {Langmuir},
  number       = {33},
  pages        = {9939--9951},
  publisher    = {American Chemical Society},
  title        = {{Influence of polarity change and photophysical effects on photosurfactant-driven wetting}},
  doi          = {10.1021/acs.langmuir.1c00769},
  volume       = {37},
  year         = {2021},
}

@article{10834,
  abstract     = {Hematopoietic-specific protein 1 (Hem1) is an essential subunit of the WAVE regulatory complex (WRC) in immune cells. WRC is crucial for Arp2/3 complex activation and the protrusion of branched actin filament networks. Moreover, Hem1 loss of function in immune cells causes autoimmune diseases in humans. Here, we show that genetic removal of Hem1 in macrophages diminishes frequency and efficacy of phagocytosis as well as phagocytic cup formation in addition to defects in lamellipodial protrusion and migration. Moreover, Hem1-null macrophages displayed strong defects in cell adhesion despite unaltered podosome formation and concomitant extracellular matrix degradation. Specifically, dynamics of both adhesion and de-adhesion as well as concomitant phosphorylation of paxillin and focal adhesion kinase (FAK) were significantly compromised. Accordingly, disruption of WRC function in non-hematopoietic cells coincided with both defects in adhesion turnover and altered FAK and paxillin phosphorylation. Consistently, platelets exhibited reduced adhesion and diminished integrin αIIbβ3 activation upon WRC removal. Interestingly, adhesion phenotypes, but not lamellipodia formation, were partially rescued by small molecule activation of FAK. A full rescue of the phenotype, including lamellipodia formation, required not only the presence of WRCs but also their binding to and activation by Rac. Collectively, our results uncover that WRC impacts on integrin-dependent processes in a FAK-dependent manner, controlling formation and dismantling of adhesions, relevant for properly grabbing onto extracellular surfaces and particles during cell edge expansion, like in migration or phagocytosis.},
  author       = {Stahnke, Stephanie and Döring, Hermann and Kusch, Charly and de Gorter, David J.J. and Dütting, Sebastian and Guledani, Aleks and Pleines, Irina and Schnoor, Michael and Sixt, Michael K and Geffers, Robert and Rohde, Manfred and Müsken, Mathias and Kage, Frieda and Steffen, Anika and Faix, Jan and Nieswandt, Bernhard and Rottner, Klemens and Stradal, Theresia E.B.},
  issn         = {0960-9822},
  journal      = {Current Biology},
  keywords     = {General Agricultural and Biological Sciences, General Biochemistry, Genetics and Molecular Biology},
  number       = {10},
  pages        = {2051--2064.e8},
  publisher    = {Elsevier},
  title        = {{Loss of Hem1 disrupts macrophage function and impacts migration, phagocytosis, and integrin-mediated adhesion}},
  doi          = {10.1016/j.cub.2021.02.043},
  volume       = {31},
  year         = {2021},
}

@article{10836,
  author       = {Pranger, Christina L. and Fazekas-Singer, Judit and Köhler, Verena K. and Pali‐Schöll, Isabella and Fiocchi, Alessandro and Karagiannis, Sophia N. and Zenarruzabeitia, Olatz and Borrego, Francisco and Jensen‐Jarolim, Erika},
  issn         = {1398-9995},
  journal      = {Allergy},
  keywords     = {Immunology, Immunology and Allergy},
  number       = {5},
  pages        = {1553--1556},
  publisher    = {Wiley},
  title        = {{PIPE‐cloned human IgE and IgG4 antibodies: New tools for investigating cow's milk allergy and tolerance}},
  doi          = {10.1111/all.14604},
  volume       = {76},
  year         = {2021},
}

@article{10838,
  abstract     = {Combining hybrid zone analysis with genomic data is a promising approach to understanding the genomic basis of adaptive divergence. It allows for the identification of genomic regions underlying barriers to gene flow. It also provides insights into spatial patterns of allele frequency change, informing about the interplay between environmental factors, dispersal and selection. However, when only a single hybrid zone is analysed, it is difficult to separate patterns generated by selection from those resulting from chance. Therefore, it is beneficial to look for repeatable patterns across replicate hybrid zones in the same system. We applied this approach to the marine snail Littorina saxatilis, which contains two ecotypes, adapted to wave-exposed rocks vs. high-predation boulder fields. The existence of numerous hybrid zones between ecotypes offered the opportunity to test for the repeatability of genomic architectures and spatial patterns of divergence. We sampled and phenotyped snails from seven replicate hybrid zones on the Swedish west coast and genotyped them for thousands of single nucleotide polymorphisms. Shell shape and size showed parallel clines across all zones. Many genomic regions showing steep clines and/or high differentiation were shared among hybrid zones, consistent with a common evolutionary history and extensive gene flow between zones, and supporting the importance of these regions for divergence. In particular, we found that several large putative inversions contribute to divergence in all locations. Additionally, we found evidence for consistent displacement of clines from the boulder–rock transition. Our results demonstrate patterns of spatial variation that would not be accessible without continuous spatial sampling, a large genomic data set and replicate hybrid zones.},
  author       = {Westram, Anja M and Faria, Rui and Johannesson, Kerstin and Butlin, Roger},
  issn         = {1365-294X},
  journal      = {Molecular Ecology},
  keywords     = {Genetics, Ecology, Evolution, Behavior and Systematics},
  number       = {15},
  pages        = {3797--3814},
  publisher    = {Wiley},
  title        = {{Using replicate hybrid zones to understand the genomic basis of adaptive divergence}},
  doi          = {10.1111/mec.15861},
  volume       = {30},
  year         = {2021},
}

@inproceedings{10847,
  abstract     = {We study the two-player zero-sum extension of the partially observable stochastic shortest-path problem where one agent has only partial information about the environment. We formulate this problem as a partially observable stochastic game (POSG): given a set of target states and negative rewards for each transition, the player with imperfect information maximizes the expected undiscounted total reward until a target state is reached. The second player with the perfect information aims for the opposite. We base our formalism on POSGs with one-sided observability (OS-POSGs) and give the following contributions: (1) we introduce a novel heuristic search value iteration algorithm that iteratively solves depth-limited variants of the game, (2) we derive the bound on the depth guaranteeing an arbitrary precision, (3) we propose a novel upper-bound estimation that allows early terminations, and (4) we experimentally evaluate the algorithm on a pursuit-evasion game.},
  author       = {Tomášek, Petr and Horák, Karel and Aradhye, Aditya and Bošanský, Branislav and Chatterjee, Krishnendu},
  booktitle    = {30th International Joint Conference on Artificial Intelligence},
  isbn         = {9780999241196},
  issn         = {1045-0823},
  location     = {Virtual, Online},
  pages        = {4182--4189},
  publisher    = {International Joint Conferences on Artificial Intelligence},
  title        = {{Solving partially observable stochastic shortest-path games}},
  doi          = {10.24963/ijcai.2021/575},
  year         = {2021},
}

@article{10852,
  abstract     = { We review old and new results on the Fröhlich polaron model. The discussion includes the validity of the (classical) Pekar approximation in the strong coupling limit, quantum corrections to this limit, as well as the divergence of the effective polaron mass.},
  author       = {Seiringer, Robert},
  issn         = {1793-6659},
  journal      = {Reviews in Mathematical Physics},
  keywords     = {Mathematical Physics, Statistical and Nonlinear Physics},
  number       = {01},
  publisher    = {World Scientific Publishing},
  title        = {{The polaron at strong coupling}},
  doi          = {10.1142/s0129055x20600120},
  volume       = {33},
  year         = {2021},
}

@inproceedings{10853,
  abstract     = {Dynamic Connectivity is a fundamental algorithmic graph problem, motivated by a wide range of applications to social and communication networks and used as a building block in various other algorithms, such as the bi-connectivity and the dynamic minimal spanning tree problems. In brief, we wish to maintain the connected components of the graph under dynamic edge insertions and deletions. In the sequential case, the problem has been well-studied from both theoretical and practical perspectives. However, much less is known about efficient concurrent solutions to this problem. This is the gap we address in this paper. We start from one of the classic data structures used to solve this problem, the Euler Tour Tree. Our first contribution is a non-blocking single-writer implementation of it. We leverage this data structure to obtain the first truly concurrent generalization of dynamic connectivity, which preserves the time complexity of its sequential counterpart, but is also scalable in practice. To achieve this, we rely on three main techniques. The first is to ensure that connectivity queries, which usually dominate real-world workloads, are non-blocking. The second non-trivial technique expands the above idea by making all queries that do not change the connectivity structure non-blocking. The third ingredient is applying fine-grained locking for updating the connected components, which allows operations on disjoint components to occur in parallel. We evaluate the resulting algorithm on various workloads, executing on both real and synthetic graphs. The results show the efficiency of each of the proposed optimizations; the most efficient variant improves the performance of a coarse-grained based implementation on realistic scenarios up to 6x on average and up to 30x when connectivity queries dominate.},
  author       = {Fedorov, Alexander and Koval, Nikita and Alistarh, Dan-Adrian},
  booktitle    = {Proceedings of the 33rd ACM Symposium on Parallelism in Algorithms and Architectures},
  isbn         = {9781450380706},
  location     = {Virtual, Online},
  pages        = {208--220},
  publisher    = {Association for Computing Machinery},
  title        = {{A scalable concurrent algorithm for dynamic connectivity}},
  doi          = {10.1145/3409964.3461810},
  year         = {2021},
}

@inproceedings{10854,
  abstract     = {Consider a distributed task where the communication network is fixed but the local inputs given to the nodes of the distributed system may change over time. In this work, we explore the following question: if some of the local inputs change, can an existing solution be updated efficiently, in a dynamic and distributed manner?
To address this question, we define the batch dynamic CONGEST model in which we are given a bandwidth-limited communication network and a dynamic edge labelling defines the problem input. The task is to maintain a solution to a graph problem on the labelled graph under batch changes. We investigate, when a batch of alpha edge label changes arrive, - how much time as a function of alpha we need to update an existing solution, and - how much information the nodes have to keep in local memory between batches in order to update the solution quickly.
Our work lays the foundations for the theory of input-dynamic distributed network algorithms. We give a general picture of the complexity landscape in this model, design both universal algorithms and algorithms for concrete problems, and present a general framework for lower bounds. The diverse time complexity of our model spans from constant time, through time polynomial in alpha, and to alpha time, which we show to be enough for any task.},
  author       = {Foerster, Klaus-Tycho and Korhonen, Janne and Paz, Ami and Rybicki, Joel and Schmid, Stefan},
  booktitle    = {Abstract Proceedings of the 2021 ACM SIGMETRICS / International Conference on Measurement and Modeling of Computer Systems},
  isbn         = {9781450380720},
  location     = {Virtual, Online},
  pages        = {71--72},
  publisher    = {Association for Computing Machinery},
  title        = {{Input-dynamic distributed algorithms for communication networks}},
  doi          = {10.1145/3410220.3453923},
  year         = {2021},
}

@article{10855,
  abstract     = {Consider a distributed task where the communication network is fixed but the local inputs given to the nodes of the distributed system may change over time. In this work, we explore the following question: if some of the local inputs change, can an existing solution be updated efficiently, in a dynamic and distributed manner? To address this question, we define the batch dynamic \congest model in which we are given a bandwidth-limited communication network and a dynamic edge labelling defines the problem input. The task is to maintain a solution to a graph problem on the labeled graph under batch changes. We investigate, when a batch of α edge label changes arrive, \beginitemize \item how much time as a function of α we need to update an existing solution, and \item how much information the nodes have to keep in local memory between batches in order to update the solution quickly. \enditemize Our work lays the foundations for the theory of input-dynamic distributed network algorithms. We give a general picture of the complexity landscape in this model, design both universal algorithms and algorithms for concrete problems, and present a general framework for lower bounds. In particular, we derive non-trivial upper bounds for two selected, contrasting problems: maintaining a minimum spanning tree and detecting cliques.},
  author       = {Foerster, Klaus-Tycho and Korhonen, Janne and Paz, Ami and Rybicki, Joel and Schmid, Stefan},
  issn         = {2476-1249},
  journal      = {Proceedings of the ACM on Measurement and Analysis of Computing Systems},
  keywords     = {Computer Networks and Communications, Hardware and Architecture, Safety, Risk, Reliability and Quality, Computer Science (miscellaneous)},
  number       = {1},
  pages        = {1--33},
  publisher    = {Association for Computing Machinery},
  title        = {{Input-dynamic distributed algorithms for communication networks}},
  doi          = {10.1145/3447384},
  volume       = {5},
  year         = {2021},
}

@article{10856,
  abstract     = {We study the properties of the maximal volume k-dimensional sections of the n-dimensional cube [−1, 1]n. We obtain a first order necessary condition for a k-dimensional subspace to be a local maximizer of the volume of such sections, which we formulate in a geometric way. We estimate the length of the projection of a vector of the standard basis of Rn onto a k-dimensional subspace that maximizes the volume of the intersection. We nd the optimal upper bound on the volume of a planar section of the cube [−1, 1]n , n ≥ 2.},
  author       = {Ivanov, Grigory and Tsiutsiurupa, Igor},
  issn         = {2299-3274},
  journal      = {Analysis and Geometry in Metric Spaces},
  keywords     = {Applied Mathematics, Geometry and Topology, Analysis},
  number       = {1},
  pages        = {1--18},
  publisher    = {De Gruyter},
  title        = {{On the volume of sections of the cube}},
  doi          = {10.1515/agms-2020-0103},
  volume       = {9},
  year         = {2021},
}

@article{10858,
  abstract     = {The cost-effective conversion of low-grade heat into electricity using thermoelectric devices requires developing alternative materials and material processing technologies able to reduce the currently high device manufacturing costs. In this direction, thermoelectric materials that do not rely on rare or toxic elements such as tellurium or lead need to be produced using high-throughput technologies not involving high temperatures and long processes. Bi2Se3 is an obvious possible Te-free alternative to Bi2Te3 for ambient temperature thermoelectric applications, but its performance is still low for practical applications, and additional efforts toward finding proper dopants are required. Here, we report a scalable method to produce Bi2Se3 nanosheets at low synthesis temperatures. We studied the influence of different dopants on the thermoelectric properties of this material. Among the elements tested, we demonstrated that Sn doping resulted in the best performance. Sn incorporation resulted in a significant improvement to the Bi2Se3 Seebeck coefficient and a reduction in the thermal conductivity in the direction of the hot-press axis, resulting in an overall 60% improvement in the thermoelectric figure of merit of Bi2Se3.},
  author       = {Li, Mengyao and Zhang, Yu and Zhang, Ting and Zuo, Yong and Xiao, Ke and Arbiol, Jordi and Llorca, Jordi and Liu, Yu and Cabot, Andreu},
  issn         = {2079-4991},
  journal      = {Nanomaterials},
  keywords     = {General Materials Science, General Chemical Engineering},
  number       = {7},
  publisher    = {MDPI},
  title        = {{Enhanced thermoelectric performance of n-type Bi2Se3 nanosheets through Sn doping}},
  doi          = {10.3390/nano11071827},
  volume       = {11},
  year         = {2021},
}

@article{10860,
  abstract     = {A tight frame is the orthogonal projection of some orthonormal basis of Rn onto Rk. We show that a set of vectors is a tight frame if and only if the set of all cross products of these vectors is a tight frame. We reformulate a range of problems on the volume of projections (or sections) of regular polytopes in terms of tight frames and write a first-order necessary condition for local extrema of these problems. As applications, we prove new results for the problem of maximization of the volume of zonotopes.},
  author       = {Ivanov, Grigory},
  issn         = {1496-4287},
  journal      = {Canadian Mathematical Bulletin},
  keywords     = {General Mathematics, Tight frame, Grassmannian, zonotope},
  number       = {4},
  pages        = {942--963},
  publisher    = {Canadian Mathematical Society},
  title        = {{Tight frames and related geometric problems}},
  doi          = {10.4153/s000843952000096x},
  volume       = {64},
  year         = {2021},
}

@unpublished{10912,
  abstract     = {Brain dynamics display collective phenomena as diverse as neuronal oscillations and avalanches. Oscillations are rhythmic, with fluctuations occurring at a characteristic scale, whereas avalanches are scale-free cascades of neural activity. Here we show that such antithetic features can coexist in a very generic class of adaptive neural networks. In the most simple yet fully microscopic model from this class we make direct contact with human brain resting-state activity recordings via tractable inference of the model's two essential parameters. The inferred model quantitatively captures the dynamics over a broad range of scales, from single sensor fluctuations, collective behaviors of nearly-synchronous extreme events on multiple sensors, to neuronal avalanches unfolding over multiple sensors across multiple time-bins. Importantly, the inferred parameters correlate with model-independent signatures of "closeness to criticality", suggesting that the coexistence of scale-specific (neural oscillations) and scale-free (neuronal avalanches) dynamics in brain activity occurs close to a non-equilibrium critical point at the onset of self-sustained oscillations.},
  author       = {Lombardi, Fabrizio and Pepic, Selver and Shriki, Oren and Tkačik, Gašper and De Martino, Daniele},
  pages        = {37},
  publisher    = {arXiv},
  title        = {{Quantifying the coexistence of neuronal oscillations and avalanches}},
  doi          = {10.48550/ARXIV.2108.06686},
  year         = {2021},
}

@article{11052,
  abstract     = {In order to combat molecular damage, most cellular proteins undergo rapid turnover. We have previously identified large nuclear protein assemblies that can persist for years in post-mitotic tissues and are subject to age-related decline. Here, we report that mitochondria can be long lived in the mouse brain and reveal that specific mitochondrial proteins have half-lives longer than the average proteome. These mitochondrial long-lived proteins (mitoLLPs) are core components of the electron transport chain (ETC) and display increased longevity in respiratory supercomplexes. We find that COX7C, a mitoLLP that forms a stable contact site between complexes I and IV, is required for complex IV and supercomplex assembly. Remarkably, even upon depletion of COX7C transcripts, ETC function is maintained for days, effectively uncoupling mitochondrial function from ongoing transcription of its mitoLLPs. Our results suggest that modulating protein longevity within the ETC is critical for mitochondrial proteome maintenance and the robustness of mitochondrial function.},
  author       = {Krishna, Shefali and Arrojo e Drigo, Rafael and Capitanio, Juliana S. and Ramachandra, Ranjan and Ellisman, Mark and HETZER, Martin W},
  issn         = {1534-5807},
  journal      = {Developmental Cell},
  keywords     = {Developmental Biology, Cell Biology, General Biochemistry, Genetics and Molecular Biology, Molecular Biology},
  number       = {21},
  pages        = {P2952--2965.e9},
  publisher    = {Elsevier},
  title        = {{Identification of long-lived proteins in the mitochondria reveals increased stability of the electron transport chain}},
  doi          = {10.1016/j.devcel.2021.10.008},
  volume       = {56},
  year         = {2021},
}

@article{11053,
  abstract     = {Understanding basic mechanisms of aging holds great promise for developing interventions that prevent or delay many age-related declines and diseases simultaneously to increase human healthspan. However, a major confounding factor in aging research is the heterogeneity of the aging process itself. At the organismal level, it is clear that chronological age does not always predict biological age or susceptibility to frailty or pathology. While genetics and environment are major factors driving variable rates of aging, additional complexity arises because different organs, tissues, and cell types are intrinsically heterogeneous and exhibit different aging trajectories normally or in response to the stresses of the aging process (e.g., damage accumulation). Tackling the heterogeneity of aging requires new and specialized tools (e.g., single-cell analyses, mass spectrometry-based approaches, and advanced imaging) to identify novel signatures of aging across scales. Cutting-edge computational approaches are then needed to integrate these disparate datasets and elucidate network interactions between known aging hallmarks. There is also a need for improved, human cell-based models of aging to ensure that basic research findings are relevant to human aging and healthspan interventions. The San Diego Nathan Shock Center (SD-NSC) provides access to cutting-edge scientific resources to facilitate the study of the heterogeneity of aging in general and to promote the use of novel human cell models of aging. The center also has a robust Research Development Core that funds pilot projects on the heterogeneity of aging and organizes innovative training activities, including workshops and a personalized mentoring program, to help investigators new to the aging field succeed. Finally, the SD-NSC participates in outreach activities to educate the general community about the importance of aging research and promote the need for basic biology of aging research in particular.},
  author       = {Shadel, Gerald S. and Adams, Peter D. and Berggren, W. Travis and Diedrich, Jolene K. and Diffenderfer, Kenneth E. and Gage, Fred H. and Hah, Nasun and Hansen, Malene and HETZER, Martin W and Molina, Anthony J. A. and Manor, Uri and Marek, Kurt and O’Keefe, David D. and Pinto, Antonio F. M. and Sacco, Alessandra and Sharpee, Tatyana O. and Shokriev, Maxim N. and Zambetti, Stefania},
  issn         = {2509-2715},
  journal      = {GeroScience},
  keywords     = {Geriatrics and Gerontology, Aging},
  number       = {5},
  pages        = {2139--2148},
  publisher    = {Springer Nature},
  title        = {{The San Diego Nathan Shock Center: Tackling the heterogeneity of aging}},
  doi          = {10.1007/s11357-021-00426-x},
  volume       = {43},
  year         = {2021},
}